CN106179541B

CN106179541B - Biochip hybridization machine

Info

Publication number: CN106179541B
Application number: CN201610216534.7A
Authority: CN
Inventors: 田平; 何太云
Original assignee: SHENZHEN RAYTO LIFE AND ANALYTICAL SCIENCES CO Ltd
Current assignee: SHENZHEN RAYTO LIFE AND ANALYTICAL SCIENCES CO Ltd
Priority date: 2016-04-08
Filing date: 2016-04-08
Publication date: 2018-10-30
Anticipated expiration: 2036-04-08
Also published as: CN106179541A

Abstract

The present invention relates to technical field of automation equipment more particularly to biochip hybridization machine, including mounting base and the loading plate for carrying biochip, the top of the mounting base is equipped with cleaning area and is incubated area, and the incubation area is equipped with incubating device；The biochip hybridization machine further includes turnover driving mechanism and horizontal drive mechanism, the turnover driving mechanism connect with the loading plate and the loading plate is driven to be overturn in the cleaning area cleaned to the biochip, and the horizontal drive mechanism and the loading plate connect and the loading plate driven to be moved back and forth between the cleaning area and the incubation area.The biochip hybridization machine of the present invention, whole process when work realize automation mechanized operation, and at least integrate biochip hybridization, biochip cleaning, manual intervention is not needed, it is ensured that operation is more accurate, and save manpower and time resource, raising efficiency prevents biochip by biological pollution.

Description

Biochip hybridization machine

Technical field

The present invention relates to technical field of automation equipment more particularly to biochip hybridization machines.

Background technology

The hybridization of existing biochip, cleaning, drying device are typically independent device, each instrument can only realize list A kind of only function, such as some Hybridization Ovens, chip cleaning device, chip drying instrument etc., are generally asked existing for these instruments Topic is：One, the turnover between each instrument, it is still desirable to which excessive manual intervention can bring error, and wave because of manual operation Take manpower and time resource, inefficiency, and excessive contact biochip can also have the risk of biological pollution；Two, Ge Geyi Having a single function of device, it is complicated；Three, there is also certain use limitation and deficiencies for simple function instrument, for example, cleaning is not Net problem, centrifugal drying can damage hybridization conjugate, cause the problem etc. of detection mistake.

Invention content

The purpose of the present invention is to solve the shortcomings of the prior art providing a kind of biochip integrating hybridization, cleaning Hybridization machines.

To achieve the above object, the technical scheme is that：Biochip hybridization machine, including mounting base and for holding The loading plate of biochip is carried, the top of the mounting base is equipped with cleaning area and is incubated area, and the incubation area, which is equipped with, to be incubated Device；The biochip hybridization machine further includes turnover driving mechanism and horizontal drive mechanism, the turnover driving mechanism and institute Loading plate is stated to connect and the loading plate is driven to be overturn in the cleaning area carry out clearly the biochip Wash, the horizontal drive mechanism connect with the loading plate and drive the loading plate the cleaning area and the incubation area it Between move back and forth.

Preferably, the turnover driving mechanism includes and provides the first driving source of power, connects with first driving source Connect with the first power driving module of passing power and with for connecting turning for the power driving module and the loading plate Axis.

Preferably, first driving source is first motor, and first power driving module includes the first belt, first Belt wheel and the second belt wheel, the first motor are installed on the loading plate, and the first end of the shaft connects with the loading plate It connects, the first pulley is connect with the main shaft of the first motor, and second belt wheel is connect with the second end of the shaft, institute The first belt is stated to be set around between the first pulley and the second belt wheel.

Preferably, the loading plate includes fixed frame and the returning face plate in the fixed frame, the first motor peace Be equipped with shaft hole loaded on the fixed frame on the fixed frame, one end of the shaft pass through the shaft hole and with the overturning Plate is fixedly connected.

Preferably, the horizontal drive mechanism includes the second driving source for providing power, is connect with second driving source With the second power driving module and guide rod of passing power, the fixed frame offers guide hole along its length, described to lead Bar is separately fixed at the both ends of the mounting base length direction, second power across the both ends of the guide hole and the guide rod Transmission group is also connect with the fixed frame.

Preferably, second driving source is the second motor, and second power driving module includes the second belt, third Belt wheel and the 4th belt wheel, second motor are installed on the mounting base, the third belt wheel and second motor Main shaft connects, and the 4th belt wheel is installed on side of the mounting base far from second motor, second belt around It is fixedly connected between the third belt wheel and the 4th belt wheel and with the fixed frame.

Preferably, the incubating device includes shell, heat generating member, cover board and elevating mechanism, and the heat generating member is installed on institute It states on mounting base and in the incubation area, the cover board is set to the top for being incubated area, the elevating mechanism and institute It states cover board to connect and be used to drive the cover board to move up and down, the jacket is set to the heat generating member, the cover board and described The outside of elevating mechanism.

Preferably, the elevating mechanism includes that third motor, cam and lifting pushing block, the third motor are fixed on described It is incubated the top in area, the cam is connect with the main shaft drives of the third motor, the bottom of the lifting pushing block and the lid Plate connects and positioned at the side of the third motor, and the lifting pushing block offers end face close to the side end of the third motor Hole, the cam is located in the end-face hole and the cam surface of the cam is abutted with the inner wall of the end-face hole.

Preferably, the incubating device further includes temperature controller, and the temperature controller is connect with the heat generating member.

Preferably, it is additionally provided with the drier that the gas in the shell is dried in the incubation area.

Preferably, the drier is the fan or exhaust fan being installed on the shell.

Preferably, the mounting base offers logical liquid bath corresponding with the cleaning zone position, under the logical liquid bath Side is connected with waste liquid pool, and waste liquid outlet is offered on the waste liquid pool.

Preferably, the cleaning area be equipped with liquid-adding device, the liquid-adding device include liquid feeding pin and with the liquid feeding pin The manipulator of the liquid feeding pin movement is connected and be used to drive, gas hole is offered in the liquid feeding pin.

Beneficial effects of the present invention：The biochip hybridization machine of the present invention, when work, biochip is positioned over loading plate On, it first adds on reaction solution to the surface of biochip, then drives loading plate to be moved from cleaning area by horizontal drive mechanism To area is incubated, it is incubated the incubation mechanism being arranged in area and incubation with heat hybridization is carried out to biochip；After the completion of hybridization, horizontal drive Mechanism drives loading plate to be moved to cleaning area from area is incubated, and after adding washing lotion, it is horizontal that turnover driving mechanism drives loading plate to carry out Overturning so that the washing lotion in biochip surface flows away, and can operate repeatedly, to realize to biochip carry out be incubated hybridization and Cleaning；After completing to the cleaning of biochip, finally it is dried, whole process realizes automation mechanized operation, and at least collect and hybridize, It cleans in one, does not need manual intervention, it is ensured that operation is more accurate, and save manpower and time resource, raising efficiency, prevents from giving birth to Object chip is by biological pollution.

Description of the drawings

Fig. 1 is the dimensional structure diagram of the biochip hybridization machine of the present invention.

Fig. 2 is the stereochemical structure signal that the turnover driving mechanism of the biochip hybridization machine of the present invention is connect with loading plate Figure.

Dimensional structure diagram when Fig. 3 is the returning face plate rollover states of the biochip hybridization machine of the present invention.

Fig. 4 is the dimensional structure diagram that the horizontal drive mechanism of the biochip hybridization machine of the present invention is connect with loading plate

Fig. 5 is the cut away view of the biochip hybridization machine of the present invention.

Reference numeral includes：

10-11-cleaning areas of mounting base, 12-incubation area

13-logical liquid bath 20-loading plate, 21-fixed frames

22-returning face plate 30-liquid-adding device, 31-liquid feeding pins

32-manipulator 40-incubating device, 41-shells

42-heat generating member 43-cover board, 44-elevating mechanisms

45-temperature controller 50-turnover driving mechanism, 51-first motors

52-the first the 54-the second belt wheel of 53-first pulley of belt

55-the 61-the second motors of 60-horizontal drive mechanism of shaft

62-the second the 64-the four belt wheel of 63-third of belt belt wheel

65-guide rod 70-drier, 80-waste liquid pools

81-waste liquid outlet 211-shaft hole, 212-guide holes

221-groove 222-shrapnel, 321-X-axis driving mechanisms

322-Y-axis driving structure 323-Z axis driving mechanism 441-third motors

442-cam 443-lifting, 4431-end-face holes of pushing block.

Specific implementation mode

The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end Same or similar label indicates same or similar element or element with the same or similar functions.Below with reference to attached The embodiment that Fig. 1~5 is described is exemplary, it is intended to for explaining the present invention, and is not considered as limiting the invention.

In the description of the present invention, it is to be understood that, term " length ", " width ", "upper", "lower", "front", "rear", The orientation or positional relationship of the instructions such as "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside" is based on attached drawing institute The orientation or positional relationship shown, is merely for convenience of description of the present invention and simplification of the description, and does not indicate or imply the indicated dress It sets or element must have a particular orientation, with specific azimuth configuration and operation, therefore should not be understood as the limit to the present invention System.

In addition, term " first ", " second " are used for description purposes only, it is not understood to indicate or imply relative importance Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or Implicitly include one or more this feature.In the description of the present invention, the meaning of " plurality " is two or more, Unless otherwise specifically defined.

In the present invention unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " fixation " etc. Term shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integral；Can be that machinery connects It connects, can also be electrical connection；It can be directly connected, can also can be indirectly connected through an intermediary in two elements The interaction relationship of the connection in portion or two elements.It for the ordinary skill in the art, can be according to specific feelings Condition understands the concrete meaning of above-mentioned term in the present invention.

As shown in Figures 1 to 5, the biochip hybridization machine that the embodiment of the present invention provides, including mounting base 10 and use It is equipped with cleaning area 11 in the top of the loading plate 20 of carrying biochip, the mounting base 10 and is incubated area 12, the incubation Area 12 is equipped with incubating device 40；The biochip hybridization machine further includes turnover driving mechanism 50 and horizontal drive mechanism 60, The turnover driving mechanism 50 connect with the loading plate 20 and the loading plate 20 is driven to be turned in the cleaning area 11 Turn cleaned to the biochip, the horizontal drive mechanism 60 connect with the loading plate 20 and drives described Loading plate 20 moves back and forth between the cleaning area 11 and the incubation area 12.When work, biochip is positioned over loading plate It on 20, first adds on reaction solution to the surface of biochip, then drives loading plate 20 from cleaning by horizontal drive mechanism 60 Area 11, which is moved to, is incubated area 12, is incubated the incubation mechanism being arranged in area 12 and carries out incubation with heat hybridization to biochip；Hybridize Cheng Hou, horizontal drive mechanism 60 drive loading plate 20 to be moved to cleaning area 11 from area 12 is incubated, and the driving of turnover driving mechanism 50 is held Support plate 20 carries out flip horizontal so that the washing lotion in biochip surface flows away, and can operate repeatedly, to realize to biochip It carries out being incubated hybridization and cleaning；It after completing to the cleaning of biochip, is finally dried, work whole process realizes automation Operation, and at least integrate hybridization, cleaning, do not need manual intervention, it is ensured that operation is more accurate, and save manpower and time money Source, raising efficiency prevent biochip by biological pollution.

In the present embodiment, the turnover driving mechanism 50 includes and provides the first driving source of power, driven with described first Dynamic source connection with the first power driving module of passing power and with for connecting the power driving module and the carrying The shaft 55 of plate 20.Specifically, power is transmitted to by the first power driving module in shaft 55 using the first driving source, so Shaft 55 rotates afterwards, while loading plate 20 connected to it being driven to rotate, and loading plate 20 makes the liquid on biochip when rotating Body flows away, and rotates loading plate 20 repeatedly and achievees the purpose that clean biochip.

In the present embodiment, in conjunction with shown in Fig. 2~3, the first embodiment of turnover driving mechanism is：Turnover driving mechanism 50 It specifically includes as the first motor 51 of the first driving source and is made of the first belt 52, first pulley 53, the second belt wheel 54 The first power driving module and shaft 55, the loading plate 20 include fixed frame 21 and the overturning in the fixed frame 21 Plate 22, the fixed frame 21 are equipped with shaft hole 211, and the first end of the shaft 55 passes through the shaft hole 211 and turned over described Flap 22 is fixedly connected, and the first motor 51 is installed on the fixed frame 21, the first pulley 53 and first electricity The main shaft of machine 51 connects, and second belt wheel 54 is connect with the second end of the shaft 55, and first belt 52 is set around institute It states between first pulley 53 and the second belt wheel 54.It is fixed specifically, biochip is positioned on loading plate 20, when needs are to life When object chip is cleaned, turnover driving mechanism 50 controls loading plate 20 and overturn realizing the cleaning to biochip. The course of work of turnover driving mechanism 50 is：First motor 51 works, and first pulley 53 is driven to rotate, and first pulley 53 drives the One belt 52 is rotated around first pulley 53 and the second belt wheel 54, due to the second belt wheel 54 and rotation connection, 54 band of the second belt wheel Turn axis 55 rotates, and since shaft 55 is fixedly connected with returning face plate 22, then returning face plate 22 can be driven to turn over when the rotation of shaft 55 Turn, when returning face plate 22 is overturn, the liquid on the biochip placed on returning face plate 22 can be made to flow away, is turned over described in overturning repeatedly Flap 22 is so as to clean biochip, and automation mechanized operation, work efficiency is high, good working effect.

The second embodiment of turnover driving mechanism 50 can also be：First driving source of turnover driving mechanism 50 can be Cylinder, and coordinate the first driving force member composition, cylinder is fixed on 22 downside of returning face plate, the piston of cylinder in centainly skewed Bar is connect with a power end of the first driving force member, another power end of the first driving force member bottom surface with returning face plate 22 again Connection, in this way, the flexible of piston rod by cylinder carries out flip horizontal action to control driving returning face plate 22, to the same energy Enough cleanings realized to the biochip on returning face plate 22.

Certainly, the first driving force member can not be singly made of the first belt 52, first pulley 53, the second belt wheel 54, also It can be chain and sprocket wheel composition, or be that lead screw is formed with travelling nut, this kind of power driving module may be implemented to move Power is driven, you can be used as the first driving force member in the present embodiment.

In the present embodiment, the horizontal drive mechanism 60 includes the second driving source for providing power, is driven with described second Source is connected with the second power driving module and guide rod 65 of passing power, and the fixed frame 21 offers along its length leads Hole 212, the guide rod 65 pass through the both ends of the guide hole 212 and the guide rod 65 to be separately fixed at 10 length side of the mounting base To both ends, the second power transmission group also connect with the fixed frame 21.Specifically, power is led to using the second driving source The second power driving module is crossed to be transmitted on fixed frame 21, so that fixed frame 21 is to be oriented to be moved along guide rod 65, by It is connect with fixed frame 21 in returning face plate 22, then returning face plate 22 is also followed by the movement of fixed frame 21, and then realizes to drive and turn over Biochip movement on flap 22.

In the present embodiment, in conjunction with shown in Fig. 4, the first embodiment of horizontal drive mechanism 60 is：State horizontal drive machine Structure 60 includes being formed as the second motor 61 of the second driving source and by the second belt 62, third belt wheel 63, the 4th belt wheel 64 The second power driving module and guide rod 65, the fixed frame 21 offer guide hole 212 along its length, the guide rod 65 is worn The both ends for crossing the guide hole 212 and the guide rod 65 are separately fixed at the both ends of 10 length direction of the mounting base, and described second Motor 61 is installed on the mounting base 10, and the third belt wheel 63 is connect with the main shaft of second motor 61, and described Four belt wheels 64 are installed on side of the mounting base 10 far from second motor 61, and second belt 62 is set around described It is fixedly connected between third belt wheel 63 and the 4th belt wheel 64 and with the fixed frame 21.60 specific works of horizontal drive mechanism When, the work of the second motor 61 drives third belt wheel 63 to rotate, and third belt wheel 63 drives the second belt 62 around 63 He of third belt wheel 4th belt wheel 64 rotates, and the second belt 62 is fixedly connected with fixed frame 21, and the second belt wheel 54 drives fixed frame 21 to move, due to solid Determine frame 21 and offers the guide hole 212 coordinated with guide rod 65, then fixed frame 21 can move in the process of moving along guide rod 65, To drive returning face plate 22 to be moved horizontally along guide rod 65, and then the biochip on returning face plate 22 can be moved from cleaning area 11 It moves the incubating device 40 for being incubated to area 12 is incubated and being arranged in area 12 and incubation with heat work is carried out to the biochip.

The second embodiment of horizontal drive mechanism 60 can also be：Horizontal drive mechanism 60 can also be by electrical cylinder, Linear module and lead screw are formed with the second driving force member that nut cooperatively forms, for example, cylinder driving lead screw rotates, on lead screw The nut of connection moves, and nut can drive fixed frame 21 to move, and fixed frame 21 can be moved using linear module as conducting wire, The biochip on driving fixed frame 21 and returning face plate 22 and returning face plate 22 can equally be realized in cleaning area 11 and be incubated area It is moved back and forth between 12, and then realizes the cleaning to biochip and incubation work.

Certainly, the second driving force member can also be chain and sprocket wheel composition or belt and belt pulley set at this kind of dynamic Power transmission may be implemented in power transmission component, you can be used as the second driving force member in the present embodiment.

In addition, in this embodiment, 22 upper surface of returning face plate offers several side by side or the groove of array 221, and Shrapnel 222 is set on groove 221, is in this way clamped in biochip in groove 221 by shrapnel 222, to realize fixation Good biochip, when overturning returning face plate 22 and when driving biochip is moved back and forth in cleaning area 11 and between being incubated area 12, Biochip is avoided to generate disengaging or displacement, scientific structure design is reasonable, highly practical.

In the present embodiment, in conjunction with shown in Fig. 5, the incubating device 40 includes shell 41, heat generating member 42, cover board 43 and lifting Mechanism 44, the heat generating member 42 is installed on the mounting base 10 and positioned at being set in the incubation area, the cover board 43 is set In the top for being incubated area 12, the elevating mechanism 44 connect with the cover board 43 and for driving about 43 cover board to transport Dynamic, the shell 41 covers at the outside of the heat generating member 42, the cover board 43 and the elevating mechanism 44.Specifically, working as water When flat driving mechanism 60 drives entire loading plate 20 to be moved in incubation area 12, starts incubating device 40 and work, first elevator Structure 44 drives cover board 43 to decline, until cover board 43 covers the top of the biochip placed on returning face plate 22, then heat generating member 42 It generates heat positioned at the lower section of returning face plate 22, due to heat generating member 42, cover board 43, elevating mechanism 44 and carries biochip Loading plate 20 is in the inside of shell 41, and heat generating member 42 can promote the temperature inside entire shell 41, to reach temperature The temperature being incubated to suitable biological core, incubation hybridization is carried out to biochip, is completed and then secondary is driven by elevating mechanism 44 Cover board 43 rises, and so recycles, and realizes automation mechanized operation.

Certainly, in other embodiments, the incubating device 40 of other structures is can also be, as long as can realize closed Space is the condition for being heated to temperature that biochip to be suitble to be incubated.

In the present embodiment, in conjunction with shown in Fig. 5, the elevating mechanism 44 is pushed away including third motor 441, cam 442 and lifting Block 443, the third motor 441 are fixed on the top for being incubated area 12, the cam 442 and the third motor 441 Main shaft drives connect, and the bottom of the lifting pushing block 443 is connect with the cover board 43 and positioned at the one of the third motor 441 Side, the lifting pushing block 443 offer end-face hole 4431 close to the side end of the third motor 441, and the cam 442 is located at In the end-face hole 4431 and the cam surface of the cam 442 is abutted with the inner wall of the end-face hole 4431.Elevating mechanism 44 has When body running, third motor 441 starts, and the main shaft of third motor 441 drives cam 442 connected to it to rotate, and cam 442 exists When rotation, the top jaw face of cam 442 can form a peak and a minimum point, and due to the cam surface of cam 442 It is abutted with the inner wall of end-face hole 4431, such cam 442 can support the inner wall of end-face hole 4431 always in rotation, and drive Entire lifting pushing block 443 carries out raising and lowering, drives lifting to push away when the top jaw face of cam 442 forms a peak Block 443 rises to peak；Lifting pushing block 443 is driven to drop to when the top jaw face of cam 442 forms a minimum point Minimum point, in this way, the cover board 43 being connect with lifting pushing block 443 can also be followed by raising and lowering, to realize control cover board 43 Cover the biochip prevented on the returning face plate 22 of loading plate 20.More specifically, end-face hole 4431 can be through-hole or blind hole.

Certainly, elevating mechanism 44 can also be cylinder, and the piston rod of cylinder is connect with the top of cover board 43, passes through cylinder The flexible realization of piston rod controls 43 raising and lowering of cover board.

In the present embodiment, in conjunction with shown in Fig. 5, the incubating device 40 further includes temperature controller 45, the temperature controller 45 and institute State the connection of heat generating member 42.Specifically, when heat generating member 42 so that shell 41 inside be heated to be suitble to biochip be incubated temperature when, Temperature controller 45 can real-time monitor temperature value, and then prevent heat generating member 42 from continuing to heat so that the temperature inside shell 41 is protected Hold the state in constant temperature, it is ensured that biochip hair is incubated to stablize and carry out, and is not influenced by excessively high or too low temperature.

In the present embodiment, in conjunction with shown in Fig. 5, it is additionally provided in the incubation area 12 and the gas in the shell 41 is done Processing is dried to biochip on being incubated area 12 in the setting of dry drier 70, i.e. drier 70.Specifically, working as When needing that biochip is dried, the returning face plate of biochip will be carried under the driving of horizontal drive mechanism 60 first In 22 mobile incubation areas 12, and the position that cover board 43 is in top is controlled, biochip need not be covered, then start drying The air in shell 41 is dried in mechanism 70, to realize the drying to biochip.

Preferably, the drier 70 is fan or exhaust fan and is installed on the shell 41；When work, wind Gas in fan or exhaust fan suction shell 41, forms air-flow, and in the fever work of heat generating member 42 on the surface of biochip Under work coordinates, thermal current is formed on the surface of biochip, to realize the drying to biochip；Drying process will not be to life Object chip damages.

Certainly, in other embodiments, drier 70 can also be centrifuge, to biochip by way of centrifugation It is dried.

In the present embodiment, the setting of drier 70 make entire biochip hybridization machine collect hybridization, cleaning and it is dry in One fully realizes that automation mechanized operation, manipulation are carried out by controller, does not need manual intervention；Be not only simple in structure it is compact, and It is simple to operate, it is efficient, it is convenient for unmanned management and biochip industrialization.

In the present embodiment, in conjunction with shown in Fig. 5, the mounting base 10 offers corresponding with 11 position of the cleaning area logical The lower section of liquid bath 13, the logical liquid bath 13 is connected with waste liquid pool 80, and waste liquid outlet 81 is offered on the waste liquid pool 80.Specifically , when returning face plate 22 is overturn, the liquid on biochip is flow into through leading to liquid bath 13 in waste liquid pool 80, and waste liquid pool 80 is collected The position progress pollution-freeization processing that waste liquid outlet 81 is expelled to setting is finally passed through in middle recycling, reasonable in design, avoids giving up Liquid pollutes the environment.

In the present embodiment, in conjunction with shown in Fig. 1, the cleaning area 11 is equipped with liquid-adding device 30, and the liquid-adding device 30 wraps The manipulator 32 for including liquid feeding pin 31 and being connect with the liquid feeding pin 31 and being used to that the liquid feeding pin 31 to be driven to move, the liquid feeding pin Gas hole (not shown) is offered in 31.Specifically, liquid feeding pin 31 can draw cleaning solution and be added on biochip, machinery Hand 32 controls liquid feeding pin 31 and is moved in three dimensions, to realize liquid feeding；And gas hole is offered in liquid feeding pin 31 then Air pump can be connected, generating air pressure by air pump blows away the extra liquid of biochip surface, is conducive to subsequently to biological core The drying of piece.

In conjunction with shown in Fig. 1, the manipulator 32 in the present embodiment is by X-axis driving mechanism 321, Y-axis driving structure 322 and Z axis Driving mechanism 323 forms, can be certainly by the cooperation of X-axis driving mechanism 321, Y-axis driving structure 322 and Z axis driving mechanism 323 Dynamic control liquid feeding pin 31 moves in three X-axis, Y-axis and Z axis directions.

The present invention known in summary is having above-described good characteristic, is able to enable it in use, is promoted previous The efficiency that does not have in technology and there is practicability, become the product of a great practical value.

The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all think ofs in the present invention Want within principle made by any modification, equivalent replacement or improvement etc., should all be included in the protection scope of the present invention.

Claims

1. biochip hybridization machine, including mounting base and the loading plate for carrying biochip, it is characterised in that：The peace The top for filling bottom plate is equipped with cleaning area and is incubated area, and the incubation area is equipped with incubating device；The biochip hybridization machine is also Including turnover driving mechanism and horizontal drive mechanism, the turnover driving mechanism connect with the loading plate and drives the carrying Plate carries out flip horizontal cleaned to the biochip in the cleaning area, the horizontal drive mechanism and institute Loading plate is stated to connect and the loading plate is driven to move back and forth between the cleaning area and the incubation area；The overturning driving Mechanism includes and provides the first driving source of power, connect the first power transmission group with passing power with first driving source Part and with the shaft for connecting the power driving module and the loading plate；First driving source is first motor, First power driving module includes the first belt, first pulley and the second belt wheel, and the first motor is installed on described hold On support plate, the first end of the shaft is connect with the loading plate, and the first pulley is connect with the main shaft of the first motor, Second belt wheel is connect with the second end of the shaft, first belt be set around the first pulley and the second belt wheel it Between；The loading plate includes fixed frame and the returning face plate in the fixed frame, and the first motor is installed on the fixation The fixed frame is equipped with shaft hole on frame, and the first end of the shaft, which passes through the shaft hole and fixed with the returning face plate, to be connected It connects.

2. biochip hybridization machine according to claim 1, it is characterised in that：The horizontal drive mechanism includes providing to move Second driving source of power connect the second power driving module and guide rod with passing power with second driving source, described Fixed frame offers guide hole along its length, and it is described that the guide rod passes through the both ends of the guide hole and the guide rod to be separately fixed at The both ends of mounting base length direction, the second power transmission group are also connect with the fixed frame.

3. biochip hybridization machine according to claim 2, it is characterised in that：Second driving source is the second motor, Second power driving module includes the second belt, third belt wheel and the 4th belt wheel, and second motor is installed on the peace It fills on bottom plate, the third belt wheel is connect with the main shaft of second motor, and the 4th belt wheel is installed on the mounting base Far from second motor side, second belt be set around between the third belt wheel and the 4th belt wheel and with institute Fixed frame is stated to be fixedly connected.

4. biochip hybridization machine according to claim 1, it is characterised in that：The incubating device includes shell, fever Part, cover board and elevating mechanism, the heat generating member is installed on the mounting base and in the incubation area, the cover board is set In the top for being incubated area, the elevating mechanism connect with the cover board and is used to drive the cover board to move up and down, described Jacket is set to the outside of the heat generating member, the cover board and the elevating mechanism.

5. biochip hybridization machine according to claim 4, it is characterised in that：The elevating mechanism include third motor, Cam and lifting pushing block, the third motor are fixed on the top for being incubated area, the master of the cam and the third motor Axis is drivingly connected, and the bottom of the lifting pushing block is connect with the cover board and positioned at the side of the third motor, the lifting Pushing block offers end-face hole close to the side end of the third motor, and the cam is located in the end-face hole and the cam Cam surface is abutted with the inner wall of the end-face hole.

6. biochip hybridization machine according to claim 4, it is characterised in that：The incubating device further includes temperature controller, The temperature controller is connect with the heat generating member.

7. biochip hybridization machine according to claim 4, it is characterised in that：It is additionally provided in the incubation area to described outer The drier that gas in shell is dried；The drier is the fan or exhaust fan being installed on the shell.

8. according to claim 1~7 any one of them biochip hybridization machine, it is characterised in that：The mounting base opens up There is logical liquid bath corresponding with the cleaning zone position, is connected with waste liquid pool below the logical liquid bath, is opened up on the waste liquid pool There is waste liquid outlet.

9. according to claim 1~7 any one of them biochip hybridization machine, it is characterised in that：The cleaning area is equipped with Liquid-adding device, the liquid-adding device include liquid feeding pin and connect and be used to drive the machine of the liquid feeding pin movement with the liquid feeding pin Tool hand offers gas hole in the liquid feeding pin.