CN106177971A - Potato starch capsule shells containing menthol - Google Patents
Potato starch capsule shells containing menthol Download PDFInfo
- Publication number
- CN106177971A CN106177971A CN201610571202.0A CN201610571202A CN106177971A CN 106177971 A CN106177971 A CN 106177971A CN 201610571202 A CN201610571202 A CN 201610571202A CN 106177971 A CN106177971 A CN 106177971A
- Authority
- CN
- China
- Prior art keywords
- glue
- parts
- potato starch
- capsule shells
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002775 capsule Substances 0.000 title claims abstract description 32
- 229920001592 potato starch Polymers 0.000 title claims abstract description 25
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 title claims abstract description 20
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 229940041616 menthol Drugs 0.000 title claims abstract description 20
- 239000003292 glue Substances 0.000 claims abstract description 25
- 239000012744 reinforcing agent Substances 0.000 claims abstract description 16
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 13
- 239000003085 diluting agent Substances 0.000 claims abstract description 11
- 239000000945 filler Substances 0.000 claims abstract description 11
- 239000000576 food coloring agent Substances 0.000 claims abstract description 11
- 239000000314 lubricant Substances 0.000 claims abstract description 11
- 239000004014 plasticizer Substances 0.000 claims abstract description 11
- 239000004094 surface-active agent Substances 0.000 claims abstract description 11
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 10
- 239000000796 flavoring agent Substances 0.000 claims abstract description 10
- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims abstract description 10
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 9
- 239000002671 adjuvant Substances 0.000 claims abstract description 8
- -1 stir Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 4
- 239000004922 lacquer Substances 0.000 claims abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 6
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 6
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 6
- GHBFNMLVSPCDGN-UHFFFAOYSA-N caprylic acid monoglyceride Natural products CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims description 6
- 239000008101 lactose Substances 0.000 claims description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 4
- 235000013399 edible fruits Nutrition 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims description 3
- 229920001661 Chitosan Polymers 0.000 claims description 3
- 244000131522 Citrus pyriformis Species 0.000 claims description 3
- 235000000177 Indigofera tinctoria Nutrition 0.000 claims description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 3
- 229920000881 Modified starch Polymers 0.000 claims description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- 150000001298 alcohols Chemical class 0.000 claims description 3
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 3
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims description 3
- 235000012730 carminic acid Nutrition 0.000 claims description 3
- 239000000679 carrageenan Substances 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 229940113118 carrageenan Drugs 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 235000010980 cellulose Nutrition 0.000 claims description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
- 229940097275 indigo Drugs 0.000 claims description 3
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 239000000473 propyl gallate Substances 0.000 claims description 3
- 235000010388 propyl gallate Nutrition 0.000 claims description 3
- 229940075579 propyl gallate Drugs 0.000 claims description 3
- VILMUCRZVVVJCA-UHFFFAOYSA-M sodium glycolate Chemical compound [Na+].OCC([O-])=O VILMUCRZVVVJCA-UHFFFAOYSA-M 0.000 claims description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 3
- 235000011152 sodium sulphate Nutrition 0.000 claims description 3
- 239000004408 titanium dioxide Substances 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 235000005979 Citrus limon Nutrition 0.000 claims description 2
- 239000005639 Lauric acid Substances 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 2
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 2
- 239000004250 tert-Butylhydroquinone Substances 0.000 claims description 2
- 235000019281 tert-butylhydroquinone Nutrition 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 235000010358 acesulfame potassium Nutrition 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 239000004519 grease Substances 0.000 claims 1
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical group [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 3
- 239000003507 refrigerant Substances 0.000 abstract description 3
- 210000002784 stomach Anatomy 0.000 abstract description 3
- 230000008673 vomiting Effects 0.000 abstract description 3
- 210000000214 mouth Anatomy 0.000 abstract description 2
- 238000007598 dipping method Methods 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 description 7
- 235000019322 gelatine Nutrition 0.000 description 7
- 108010010803 Gelatin Proteins 0.000 description 6
- 239000008273 gelatin Substances 0.000 description 6
- 235000011852 gelatine desserts Nutrition 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 108010011485 Aspartame Proteins 0.000 description 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000000605 aspartame Substances 0.000 description 2
- 235000010357 aspartame Nutrition 0.000 description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical group OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
- 229960003438 aspartame Drugs 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- XKZQKPRCPNGNFR-UHFFFAOYSA-N 2-(3-hydroxyphenyl)phenol Chemical compound OC1=CC=CC(C=2C(=CC=CC=2)O)=C1 XKZQKPRCPNGNFR-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- USEBIPUIVPERGC-UHFFFAOYSA-N Dibutylone Chemical compound CCC(N(C)C)C(=O)C1=CC=C2OCOC2=C1 USEBIPUIVPERGC-UHFFFAOYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 244000173166 Pyrus ussuriensis Species 0.000 description 1
- 235000011572 Pyrus ussuriensis Nutrition 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000004566 building material Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- WQPDQJCBHQPNCZ-UHFFFAOYSA-N cyclohexa-2,4-dien-1-one Chemical compound O=C1CC=CC=C1 WQPDQJCBHQPNCZ-UHFFFAOYSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229940074046 glyceryl laurate Drugs 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001835 salubrious effect Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Confectionery (AREA)
Abstract
The invention discloses a kind of potato starch capsule shells containing menthol, belong to pharmacy or food processing；Taste preference is good, taste is refrigerant to aim to provide one, has preventing or arresting vomiting antibacterial action, increases oral cavity and the amylan softgel shell of stomach comfort.It is by potato starch and adjuvant: menthol, reinforcing agent, plasticizer, food coloring, lubricant, disintegrating agent, surfactant, diluent, antioxidant, filler, flavouring agent are prepared from: be dispersed in water by potato starch, heats to obtain gelatinizing glue；Add described adjuvant, stir, glue must be dipped in；Ensure to dip in glue temperature be 72 75 DEG C, lacquer disk(-sc) temperature be 45 48 DEG C, drying tunnel temperature be 62 65 DEG C；Dipping in glue vacuum defoaming, then employing is dipped in glue legal system and is obtained capsule shells, is dried 48 hours.
Description
Technical field
The present invention relates to a kind of capsule shells, particularly relate to a kind of capsule shells with potato starch as primary raw material；Belong to system
Medicine or food processing field.
Background technology
Capsule shells is a kind of ovum shape hollow casing for containing solid powder particle, and the content that it is contained enters together
Enter digestion, can rapidly, reliably, dissolve safely；It is mainly used in the field such as medicine and health food, it is possible to resolve medicine
Difficult entrance, mouthfeel are poor, the uncomfortable problem of stomach.
At present, widely used capsule shells is processed by gelatin mostly.A lot of enterprises, for reducing production cost, use bad
Matter Chalcanthitum hide glue is as the raw materials for production of medicinal hollow capsule, not only bacterial content severe overweight, and also content is the highest
The carcinogens such as crome metal.It addition, gelatin is prone to, with containing medicine crosslinkings such as aldehyde, reducing sugar base class compound and vitamin Cs, make gelatin
Shell water solublity is deteriorated, and causes capsule shells disintegrate and capsule 's content dissolution to postpone.3rd, gelatin is also easily generated in dry conditions
Build-up of electrostatic charges, has an impact following process.4th, it is stored in the environment of low humidity for a long time, gelatin easily becomes fragile and causes glue
Capsule is broken.5th, due to religious reasons, gelatine capsule is repelled by Moslem and Jewry and vegetarian,
It is unfavorable for the popularization of pharmaceutical capsules.Therefore, the capsule shells antibacterial, preventing or arresting vomiting effect that has of exploitation plant origin has reality meaning
Justice.It addition, how to allow capsule shells present the problem that salubrious taste, always businessman are expected to solve, once this problem
It is addressed, so that it may can welcome huge business opportunity.
Potato starch have gel strength gelatinizing big, easy, dissolubility is high, water swellability strong, the transparency of gelatinized corn starch relatively
The features such as under good, high temperature viscosity is stable.Potato starch structure and qualitative uniqueness determine potato starch can be full
The requirement of some special applications industries of foot: the alternative virgin rubber of potato starch, hydroxymethyl cellulose produce for fruit jelly；Potato starch
Stick with paste liquid good film-forming property, therefore can be used for paper industry with the Oxytarch of potato starch production, cationic starch etc.；Rhizoma Solani tuber osi aoxidizes
Starch has wide market at aspects such as medicine, building materials, oil drillings.
Menthol is the natural function food resource integrating health-care and edible flavouring, Oleum menthae freezing tie
Brilliant, saponification, distillation obtains；There is refrigerant, antiinflammatory, analgesic effect, also there is the strongest oxidation resistance.It is widely used in tooth
In cream, perfume, beverage and confection.
Traditional raw material can not meet above-mentioned requirements, and the unique function of menthol can solve traditional material and cannot solve
Problem.At present, the pertinent literature of the capsule shells not yet finding with potato starch as primary raw material and contain menthol.
Summary of the invention
In order to overcome defect present in prior art, it is desirable to provide a kind of, taste preference is good, taste is refrigerant, has
Preventing or arresting vomiting antibacterial action, increase oral cavity and the potato starch capsule shells containing menthol of stomach comfort.
To achieve these goals, the present invention by the following technical solutions: it is prepared from by the raw material of following weight portion,
Major ingredient: potato starch 100 parts, adjuvant: menthol 0.01～3 parts, reinforcing agent 5～20 parts, plasticizer 1～3 parts, food coloring
0.1～1 part, lubricant 0.1～2 parts, disintegrating agent 0.1～2 parts, surfactant 0.4～3 parts, diluent 0.1～2 parts, antioxygen
Agent 0.4～4 parts, filler 0.2～1 part, flavouring agent 0.3～2 parts；Its preparation process is as follows:
1) by potato starch and 140 parts of water heats of mixing to 60～90 DEG C, stir 15～30 minutes, obtain gelatinizing glue；
2) described adjuvant is added in above-mentioned gelatinizing glue, stir, glue must be dipped in；Ensure to dip in glue temperature be 72-75 DEG C,
Lacquer disk(-sc) temperature is 45-48 DEG C, drying tunnel temperature is 62-65 DEG C；
3) the described glue that dips in being carried out vacuum defoaming process, then employing is dipped in glue legal system and is obtained capsule shells, is dried 48 hours.
The further technical scheme of the present invention is: described reinforcing agent is 10～15 parts.
The present invention further technical scheme is: described reinforcing agent is chitosan, hydroxypropyl methyl cellulose, carboxymethyl
One or more in sodium cellulosate, cellulose sodium sulfate, carrageenan；Described plasticizer is glycerol, propylene glycol, glycerol, Pyrusussuriensis
One or more in sugar alcohol, maltose alcohol, red liquor-saturated alcohol, xylitol, maltose alcohol etc.；Described food coloring is carmine, lemon
Lemon is yellow, indigo, titanium dioxide one or more；Described lubricant is magnesium stearate or Pulvis Talci；First elected as by described disintegrating agent
One or more in base Starch Sodium, polyvinylpyrrolidone, sodium glycollate, microcrystalline Cellulose；Described surfactant is ten
In sodium dialkyl sulfate, Polyethylene Glycol glycerol caprylate, Polyethylene Glycol glyceryl laurate ester, Polyethylene Glycol tristerin
One or more；Described diluent is lactose or pregelatinized Starch；Described antioxidant is Butylated hydroxyanisole, dibutyl
One or more in hydroxy-methylbenzene, propylgallate and tert-butylhydroquinone；Described filler is lactose, phosphoric acid
One or more in calcium, sorbitol, glycine；Described flavouring agent is Aspartame or fruit essence.
The present invention further technical scheme is: the mixing time in step 1) is 20～25 minutes, and heating-up temperature is
70～80 DEG C.
Compared with the prior art, due to the fact that and have employed technique scheme, with potato starch as primary raw material, therefore
It is pure natural plant capsule shells, there is high safety, do not spread disease, be difficult to by advantages such as microorganism infection；It addition, with Rhizoma Solani tuber osi
Starch replacing gelatin, therefore can meet the demand of the special population such as Islamic, vegetarian；3rd, starch material source is wide, can be again
Raw, low cost, can be effectively reduced product price；4th, owing to the addition of menthol, it is clear that capsule shells can present light Herba Menthae
Cool taste, improves the puckery sensation of existing capsule shells mouthfeel, the taste preference of raising capsule shells.
Capsule shells of the present invention is with low cost, good film-forming property, and disintegration, friability, overall dimensions, microbial limit
Meet Chinese Pharmacopoeia etc. index and specify the standard of hollow core hard capsule case.It addition, capsule shells of the present invention is not affected by air humidity
Capsules is caused to become fragile or deliquescing, it is possible to decrease the requirement to production environment.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described:
Embodiment 1
1) get the raw materials ready
Weigh major ingredient: potato starch 100g, adjuvant: menthol 0.01g, reinforcing agent 20g, plasticizer 1g, food coloring 1g, lubrication
Agent 0.1g, disintegrating agent 2g, surfactant 0.4g, diluent 2g, antioxidant 0.4g, filler 1g, flavouring agent 0.3g；
2) above-mentioned potato starch is dispersed in 140g water, is placed in constant temperature magnetic force stirring in water bath pot and is heated to 90 DEG C, stir 15
Minute, obtain gelatinizing glue；
3) above-mentioned adjuvant is added in above-mentioned gelatinizing glue, stir, glue must be dipped in；Ensure to dip in glue temperature be 72-75 DEG C,
Lacquer disk(-sc) temperature is 45-48 DEG C, drying tunnel temperature is 62-65 DEG C；
4) the described glue that dips in being carried out vacuum defoaming process, then employing is dipped in glue legal system and is obtained capsule shells, is dried 48 hours.
Embodiment 2, each step is with embodiment 1；Wherein, menthol 3g, reinforcing agent 5g, plasticizer 3g, food coloring 0.1g,
Lubricant 2g, disintegrating agent 0.1g, surfactant 3g, diluent 0.1g, antioxidant 4g, filler 0.2g, flavouring agent 2g；Step
Rapid 2) heating-up temperature in is 60 DEG C, and mixing time is 30 minutes.
Embodiment 3, each step is with embodiment 1；Wherein, menthol 1.5g, reinforcing agent 12g, plasticizer 2g, food coloring
0.5g, lubricant 1g, disintegrating agent 1g, surfactant 1.7g, diluent 1g, antioxidant 2.2g, filler 0.6g, flavouring agent
1.1g；Step 2) in heating-up temperature be 75 DEG C, mixing time is 22 minutes.
Embodiment 4, each step is with embodiment 1；Wherein, reinforcing agent is 10g；Step 2) in heating-up temperature be 80 DEG C, stir
The time of mixing is 20 minutes.
Embodiment 5, each step is with embodiment 1；Wherein, reinforcing agent is 15g；Step 2) in heating-up temperature be 70 DEG C, stir
The time of mixing is 25 minutes.
Embodiment 6, each step is with embodiment 1；Wherein, reinforcing agent is 12.5g；Step 2) in heating-up temperature be 75 DEG C,
Mixing time is 22 minutes.
Embodiment 7, each step is with embodiment 1；Wherein, menthol 1g, reinforcing agent 10g, plasticizer 1g, food coloring
0.5g, lubricant 0.8g, disintegrating agent 0.2g, surfactant 0.9g, diluent 1g, antioxidant 2g, filler 0.6g, fragrance
Agent 0.8g.
Embodiment 8, each step is with embodiment 1；Wherein, menthol 2.5g, reinforcing agent 6g, plasticizer 2.5g, food coloring
0.7g, lubricant 1.2g, disintegrating agent 1.6g, surfactant 2.5g, diluent 1.4g, antioxidant 2.5g, filler 1.6g,
Flavouring agent 1.7g.
In the various embodiments described above:
Described reinforcing agent is in chitosan, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, cellulose sodium sulfate, carrageenan
One or more.
Described plasticizer is glycerol, propylene glycol, glycerol, Sorbitol, maltose alcohol, red liquor-saturated alcohol, xylitol, maltose alcohol
One or more in Deng.
Described food coloring be carmine, lemon yellow, indigo, titanium dioxide one or more.
Described lubricant is magnesium stearate or Pulvis Talci.
Described disintegrating agent elect as the one in methyl starch sodium, polyvinylpyrrolidone, sodium glycollate, microcrystalline Cellulose or
Several.
Described surfactant is sodium lauryl sulphate, Polyethylene Glycol glycerol caprylate, Polyethylene Glycol lauric acid
One or more in ester, Polyethylene Glycol tristerin.
Described diluent is lactose or pregelatinized Starch.
Described antioxidant is that Butylated hydroxyanisole, dibenzylatiooluene, propylgallate and tertiary butyl are to benzene
One or more in diphenol.
Described filler is one or more in lactose, calcium phosphate, sorbitol, glycine.
Described flavouring agent is Aspartame or fruit essence.
Claims (4)
1. the potato starch capsule shells containing menthol, it is characterised in that: it is prepared from by the raw material of following weight portion, main
Material: potato starch 100 parts, adjuvant: menthol 0.01～3 parts, reinforcing agent 5～20 parts, plasticizer 1～3 parts, food coloring 0.1
～1 part, lubricant 0.1～2 parts, disintegrating agent 0.1～2 parts, surfactant 0.4～3 parts, diluent 0.1～2 parts, antioxidation
Agent 0.4～4 parts, filler 0.2～1 part, flavouring agent 0.3～2 parts；Its preparation process is as follows:
1) by potato starch and 140 parts of water heats of mixing to 60～90 DEG C, stir 15～30 minutes, obtain gelatinizing glue；
2) described adjuvant is added in above-mentioned gelatinizing glue, stir, glue must be dipped in；Ensure to dip in glue temperature be 72-75 DEG C,
Lacquer disk(-sc) temperature is 45-48 DEG C, drying tunnel temperature is 62-65 DEG C；
3) the described glue that dips in being carried out vacuum defoaming process, then employing is dipped in glue legal system and is obtained capsule shells, is dried 48 hours.
Potato starch capsule shells containing menthol the most according to claim 1, it is characterised in that: described reinforcing agent is 10
～15 parts.
Potato starch capsule shells containing menthol the most according to claim 1 and 2, it is characterised in that: described reinforcing agent
For one or more in chitosan, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, cellulose sodium sulfate, carrageenan；Institute
Stating plasticizer is the one in glycerol, propylene glycol, glycerol, Sorbitol, maltose alcohol, red liquor-saturated alcohol, xylitol, maltose alcohol etc.
Or it is several；Described food coloring be carmine, lemon yellow, indigo, titanium dioxide one or more；Described lubricant is stearic
Acid magnesium or Pulvis Talci；Described disintegrating agent is elected as in methyl starch sodium, polyvinylpyrrolidone, sodium glycollate, microcrystalline Cellulose
One or more；Described surfactant is that sodium lauryl sulphate, Polyethylene Glycol glycerol caprylate, Polyethylene Glycol lauric acid are sweet
One or more in grease, Polyethylene Glycol tristerin；Described diluent is lactose or pregelatinized Starch；Described anti-
Oxidant be the one in Butylated hydroxyanisole, dibenzylatiooluene, propylgallate and tert-butylhydroquinone or
Several；Described filler is one or more in lactose, calcium phosphate, sorbitol, glycine；Described flavouring agent is Abbas
Sweet or fruit essence.
Potato starch capsule shells containing menthol the most according to claim 1 and 2, it is characterised in that: in step 1)
Mixing time is 20～25 minutes, and heating-up temperature is 70～80 DEG C.
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| CN201610571202.0A CN106177971A (en) | 2016-07-20 | 2016-07-20 | Potato starch capsule shells containing menthol |
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| CN108992417A (en) * | 2018-09-27 | 2018-12-14 | 宁波大红鹰药业股份有限公司 | A kind of capsule shells and preparation method thereof preventing adherency oral cavity |
| CN109528678A (en) * | 2019-01-14 | 2019-03-29 | 武汉海吉亚生物科技有限公司 | A kind of hydroxypropyl methylcellulose capsules and its preparation method and application |
| CN110327471A (en) * | 2019-01-24 | 2019-10-15 | 北京歌斐医疗器械有限公司 | A kind of endoscopy spasmolysis defoaming agent and preparation method thereof |
| CN113041229A (en) * | 2021-02-09 | 2021-06-29 | 深圳市新指南医学科技发展有限公司 | Modified potato starch empty capsule shell and preparation method thereof |
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