CN106177745A - A kind of Chinese medicinal formulae treating primary hepatocarcinoma - Google Patents

Abstract

The present invention relates to a kind of Chinese medicinal formulae treating primary hepatocarcinoma.Its prescription is made up of the Chinese medicine of following weight portion: Fructus Camptothecae Acuminatae, Rhizoma Polygonati, Herba Hedyotidis Diffusae, Radix Bupleuri, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longae, Radix Curcumae, Radix Tripterygii Wilfordii, Herba Mimosae Pudicae, Radix Glycyrrhizae Preparata.This Chinese medicine is through scientific composition, and verifies curative effect through experimentation and Clinical practice for many years.It has good curative effect to primary hepatocarcinoma, can effectively extend the life cycle of liver cancer patient.

Description

A kind of Chinese medicinal formulae treating primary hepatocarcinoma

Technical field

The present invention relates to the field of Chinese medicines, for a kind of Chinese medicinal formulae treating primary hepatocarcinoma.

Background technology

Malignant tumor is the commonly encountered diseases of serious threat human life, frequently-occurring disease.Wherein primary hepatocarcinoma is that sickness rate rises in recent years One of the fastest tumor, its mortality rate is positioned at the 2nd because of cancer mortality.According to statistics, the hepatocarcinoma in the whole world 50% is in China.With Time, China is again the country that hepatitis B is occurred frequently, wherein has the hepatitis B patient of 20-30% can develop into liver cirrhosis and then differentiation For hepatocarcinoma.Hepatocarcinoma onset is hidden, and disease progression is rapid, and aggressivity is strong, poor prognosis, life cycle are short, be referred to as " in cancer it King ".And the most effectively counter-measure is excision.But this measure is only applicable to the liver cancer patient less than 1/3, really When examining, Most patients has reached Locally Advanced or metastasis has occurred, and has lost the chance of operation.So, major part liver Being primarily intended to of carninomatosis people is chemicotherapy.And the most unique generally acknowledged effective such anti-liver cancer and anti-therapy is Sorafenib, but curative effect is the most undesirable, is only capable of making the average life of the liver cancer patient in Asia extend to 6.2 months from 4.1 months. And owing to most chemotherapeutics are while killing cancerous cell, also damage the cell of human normal；Foreign literature proves: puts, change Treat and promote neoplasm metastasis to a certain extent, reduce life in patients, even result in short survival.The morbidity situation of hepatocarcinoma Precarious, treatment means is most deficient, and therapeutic effect is barely satisfactory.Therefore, to have the hepatocarcinoma of Comprehensive Treatment function new in exploitation Medicine is extremely urgent.

TCM on Tumor has long history, the classics side's medicine/prescription of ancient medicine treatment tumor also to pass on application so far, as XIAOJIN DAN, XIHUANG WAN, Radix Et Rhizoma Rhei et Eupolyphaga Seu Steleophaga Pilulae, LIUSHEN WAN, Pien Tze Huang, Ramulus Cinnamomi Poria pill, Sargassum jade kettle ball, danggui longhui pills, danggui longhui wan, Melnikov's method etc., these tradition prescriptions have the effect of heat-clearing and toxic substances removing, hard masses softening and resolving more, improving clinical symptoms, are suppressing swollen Tumor growth aspect shows certain curative effect.Chinese traditional treatment tumor is in line with the principle determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of " cure the disease and must ask it ", all the time Run through the Chinese traditional treatment rule for the treatment of such as " strengthening vital QI to eliminate pathogenic factors ", " giving consideration to both the incidental and fundamental ", " disease combination ", the present stage treatment malignant tumor traditional Chinese medical science Treatment basic principle includes the body resistance strengthening and constitution consolidating, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, hard masses softening and resolving etc..The traditional Chinese medical science is according to pathology multifactor, many Characteristic of disease feature, with compound preparation comprehensive function in tumor cell and human body, can make a concerted effort to hit many aspects with Mutiple Targets, rise Effect to comprehensive effect.Over nearly 20 years, Chinese scholar reports the achievement in research utilizing TCM on Tumor in a large number, as answered With the treatment tumor such as kind capsule, gram tumor capsule, cinobufacin, Kang ' ai injection or cancerous pain, to the life improving tumor patient Deposit quality, symptom management development, extend the aspect such as life cycle and achieve gratifying results.But at present by being specifically applied to Primary Hepatic The Chinese medicine preparation still vacancy that the Chinese medicinal formulae of cancer treatment develops.

Summary of the invention

This invention provides a kind of Chinese medicinal formulae being specifically applied to treat primary hepatocarcinoma, applicable develop into all kinds of main in Medicine preparation, fills up domestic sole duty for treating the blank of primary hepatocarcinoma Chinese medicine preparation.Provided by the present invention primary for treating Property hepatocarcinoma Chinese medicinal formulae there is determined curative effect, refining formula safety, be suitable for the feature of new Chinese medicine exploitation.

The technical solution used in the present invention is:

A kind of Chinese medicinal formulae treating primary hepatocarcinoma, is characterized in that being made up of the Chinese medicine of following weight portion:

Fructus Camptothecae Acuminatae 15-45 part, Rhizoma Polygonati 15-45 part, Herba Hedyotidis Diffusae 15-45 part, Radix Bupleuri 5-15 part, Radix Salviae Miltiorrhizae 15-45 Part, Rhizoma Curcumae Longae 5-15 part, Radix Tripterygii Wilfordii 5-15 part, Herba Mimosae Pudicae 10-20 part, Radix Curcumae 5-15 part, Radix Glycyrrhizae Preparata 5-10 part.

As preference:

Described raw material of Chinese medicine weight portion constitutes as follows: Fructus Camptothecae Acuminatae 20-40 part, Rhizoma Polygonati 20-40 part, Herba Hedyotidis Diffusae 20-40 Part, Radix Bupleuri 9-12 part, Radix Salviae Miltiorrhizae 20-40 part, Rhizoma Curcumae Longae 9-12 part, Herba Mimosae Pudicae 12-18 part, Radix Tripterygii Wilfordii 9-12 part, Radix Curcumae 9-12 part, Radix Glycyrrhizae Preparata 5-10 part.

Further preferably described raw material of Chinese medicine weight portion is configured to: Fructus Camptothecae Acuminatae 30 parts, Rhizoma Polygonati 30 parts, Herba Hedyotidis Diffusae 30 Part, Radix Bupleuri 10 parts, Radix Salviae Miltiorrhizae 30 parts, 10 parts of Rhizoma Curcumae Longae, Radix Tripterygii Wilfordii 10 parts, Herba Mimosae Pudicae 15 parts, Radix Curcumae 10 parts, Radix Glycyrrhizae Preparata 6 parts.

The function of Chinese medicinal formulae of the present invention cures mainly as heat-clearing and toxic substances removing, vital energy regualting and blood circulation-promoting, hard masses softening and resolving, strengthening vital QI to eliminate pathogenic factors. Treatment for primary hepatocarcinoma.Its prescription side's solution i.e. mechanism of action is:

Hepatocarcinoma is with internal organs deficiency of qi and blood for this, and the stagnation of QI, blood stasis, expectorant are turbid, cancer is malicious becomes mark mutually.We's treating both the principal and secondary aspects of a disease, Formula is with eliminating pathogenic factor for supporting vital QI for prescription basic principle.Fructus Camptothecae Acuminatae heat-clearing and toxic substances removing in side, eliminating stagnation disappears；Rhizoma Polygonati boosting qi and nourishing yin, Tonifying speen and tonifying kidney, two medicines one are main eliminating evil, and a main righting, treating both the principal and the secondary aspects of a disease at the same time is monarch drug altogether.Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, lives Blood and dissolving stasis, relieving stranguria by diuresis, helps Fructus Camptothecae Acuminatae heat-clearing and toxic substances removing, and blood stasis of dispelling, the merit that dampness removing is turbid；Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, Fructus Camptothecae Acuminatae eliminating stagnation is helped to disappear；Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, removing heat from blood eliminating carbuncle, Shennong's Herbal calls its " main heart Abdomen pathogen, cold and heat gather, abolish abdominal mass, only stuffy sensation with restlessness, QI invigorating "；Rhizoma Curcumae Longae removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia, " Xin Xiuben Grass " " main trusted subordinate ties long-pending, therapeutic method to keep the adverse QI flowing downwards removing blood stasis, except wind heat, subduing inflammation Rhizoma Curcumae Longae." record.Four medicine degasification are stagnant, change and become silted up Blood, dampness removing is turbid, solves cancer poison, and the poly-principal drug assistance of scattered plot divides all heresies that disappears to think minister.Radix Tripterygii Wilfordii heat-clearing and toxic substances removing, energy treating the poisonous disease with poisonous drugs, Reducing swelling and alleviating pain；Herba Mimosae Pudicae removing pathogenic heat from blood and toxic substance from the body, clearing away heat-damp and promoting diuresis, tranquillizing and allaying excitement.Radix Curcumae promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, function of gallbladder promoting Jaundice eliminating；Upper three medicine solution cancer poison, dampness removing is turbid, regulates the flow of vital energy stagnant, dissipates abdominal mass, and can be with jaundice eliminating subcutaneous ulcer, and relieve the pain pain, helps sleeping changing The life quality of kind patient, is adjuvant drug altogether.Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription, QI invigorating and in and for making medicine.The all medicine rightings in total side Gas, disappear all heresies, makes healthy energy multiple, and all heresies are gone, and improve liver cancer patient life quality, the notable life that gets nowhere extending sufferer Deposit the phase.

In prescription, the pharmacological action of each compatibility Chinese medicine is described below:

Fructus Camptothecae Acuminatae: for the fruit of Nyssaceae plant camptotheca acuminata.Bitter in the mouth, pungent, cold in nature, poisonous.Function heat-clearing and toxic substances removing, eliminating stagnation disappears. Its main component has camptothecine, 10-hydroxycamptothecine, deoxycamptothecine, venoterpine etc., for antitumor common medicine.Clinical main Treating the liver cancer, the esophageal carcinoma, pulmonary carcinoma etc., and can be used for treating carcinous pleural effusions and ascites.Early-stage Study confirms that its anticancer mechanism mainly has Cytotoxicity, cancer cell specific induction of apoptosis, metastasis, Antineoplastic angiogenesis etc., be a characteristic warp of Chinese traditional treatment hepatocarcinoma Test medication.

Rhizoma Polygonati: sweet, flat, enters spleen, lung, kidney channel.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, effect of kidney tonifying.Face Bed is for rheumatism, muscles and bones weakness, hemoptysis etc..

Herba Hedyotidis Diffusae: mildly bitter flavor, cold in nature, stomach, large intestine, small intestine meridian.There is heat-clearing and toxic substances removing, effect of diuresis of blood circulation promoting.Face Bed is for tonsillitis, pharyngolaryngitis, urinary tract infection, hepatitis, tumor etc..Modern pharmacology confirms that it can enhancing body be exempted from Epidemic disease power, suppresses growth of tumour cell, strengthens phagocytosis.

Radix Bupleuri: acrid in the mouth, hardship, cold nature, returns liver, gallbladder, lung meridian.Reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, bring down a fever and cut Malaria.Clinic is used for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis etc., and has guarantor The pharmacology of liver is used.

Radix Salviae Miltiorrhizae: bitter in the mouth, is slightly cold, GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle.Clinical use In obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, the accumulation of abdominal mass abdominal mass, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea, skin infection swells and ache. There is antihepatitic activity.

Rhizoma Curcumae Longae: pungent, bitter, temperature, return spleen, Liver Channel.Removing blood stasis circulation of qi promoting, relieving pain of dysmenorrhea.Be clinically used for breast the side of body twinge, obstruction of qi in the chest and cardialgia, Dysmenorrhea amenorrhea, lump in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.

Herba Mimosae Pudicae: sweet, puckery, is slightly cold cool, enters large intestine, liver, stomach, heart channel.Have mind tranquilizing and the heart calming, clearing away heat-damp and promoting diuresis, removing heat from blood solution Toxic action.It is clinically used for vomiting and diarrhoea, insomnia, infantile malnutrition, conjunctival congestion and swelling pain, deep abscess, herpes zoster, hepatitis etc..Have Antivirus action.

Radix Tripterygii Wilfordii: bitter, acrid, cold.Very toxic.Enter liver, kidney channel.Function heat-clearing and toxic substances removing, treating the poisonous disease with poisonous drugs, reducing swelling and alleviating pain.

Radix Curcumae: pungent, bitter, cool, enters the heart, lung, Liver Channel.Function promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Can be clinically used for chest and abdomen side of body rib All pains and lose that the heart is demented, calentura coma, haematemesis, epistaxis, hematuria, stranguria with blood, jaundice etc..

Radix Glycyrrhizae Preparata: sweet, flat, enters the heart, lung, spleen, stomach warp.There is the multiple arteries and veins of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, delay Anxious pain relieving, effect of coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction Anxious pain, carbuncle sore tumefacting virus, cushion toxicity, strong.

Clinical research

Because by national policy reason, Chinese medicinal formulae of the present invention still cannot be carried out strict scale trials.But warp Clinical verification for many years and the Follow-up Data statistics display of 30 example liver cancer patients, use with prescription of the present invention for the treatment of basic side primary Property hepatocarcinoma, the average of patient reaches more than 1 year without disease developing time (PFS), and the PFS shortest time is 6 months, maximum duration Reach 18 years, averagely average far above current hepatocarcinoma main flow chemicotherapy therapy without disease developing time without disease developing time (PFS) (PFS) level of about 6 months.

Typical clinical case

Case 1:

Yin, man, 41 years old, within 33 years old, rise, often send out hepatalgia, and with low grade fever, body temperature often between 37.5 DEG C to 38 DEG C, Liver function test is without difference.When 37 years old, hospital's puncture diagnosis, claims it may suffer from hepatitis, but clarifies a diagnosis.This year 5 Month, to call oneself because of cold, fever, hepatalgia is aggravated suddenly, and pain is acupuncture sample.Show have individual interior at certain hospital's fluoroscopic examination Lateral movement weakens.After go to certain hospital to do radioisotope scan immediately, be diagnosed as hepatic space occupying lesion.Hou Youqumou hospital does liver again and sweeps Retouching, diagnosis is the same.Had a medical check-up at that time lower 3 centimeters of the swollen rib of liver, medium hardness, touch a tender spot substantially.Laboratory inspection: r-GT52u, LDH560u, AFP are positive, are diagnosed as hepatocarcinoma, then live the treatment of certain institute.Through in many ways processing, low grade fever, hepatalgia do not obtain substantially Improving, overall health of patients is also on the rise, and examines in JIUYUE.Quarter examines, hepatalgia, low grade fever, body temperature 37.6 DEG C, emaciated physique, Gastral cavilty distension, poor appetite, greenish complexion are dark, Mental fatigue, breathe hard, deep-thready pulse stringy and rapid pulse, body of the tongue green grass or young crops is red, have ecchymosis, white and thin fur.Physique Checking, palpation of liver under rib 5 centimeters, surface is the most smooth, medium hardness, touches a tender spot substantially.Agree to diagnosing cancer of liver.The traditional Chinese medical science Dialectical for the disease being located in the liver kidney, involve taste, card belongs to deficiency of both QI and YIN, qi depression to blood stasis.Give prescription of the present invention, after taking medicine two weeks, patient Subjective symptoms the most substantially alleviates.Taking medicine half a year continuously, all diseases all disappear, and lab testing AFP turns negative, r-GT, LDH etc. All become a full member and often leave hospital.Continue after leaving hospital to carry out outpatient service, consolidate with prescription of the present invention plus-minus, drug withdrawal and resuming work after a year.For many years Carry out full-time job always, energetic, there is not recurrence.Follow up a case by regular visits to 59 years old still be still living and in good health.

Case 2:

Tang, man, time medical 52 years old, when 40 years old, be diagnosed as hepatitis B virus carriers, medical front 6 menstruation B ultrasonic, CT and Pathological diagnosis is primary hepatocarcinoma, and local doctor thinks that operation and chemicotherapy meaning are the most little, it is proposed that use Chinese medicine expectant treatment. After examining, employing is taken prescription of the present invention and is main formula and adds and subtracts treatment to the ill, has lasted 3 years, current patient experiences stable disease, raw Bioplasm amount is greatly improved.

Prescription the most of the present invention is safe and effective to the treatment of primary hepatocarcinoma, can effectively extend liver cancer patient life cycle and Improve life quality, and refining formula, be especially suitable for developing into Chinese medicine preparation (patent medicine).

Detailed description of the invention

Below in conjunction with embodiment, the present invention is further illustrated.

Embodiment 1

Weigh Fructus Camptothecae Acuminatae 30 parts, Rhizoma Polygonati 30 parts, Herba Hedyotidis Diffusae 30 parts, Radix Bupleuri 10 parts, Radix Salviae Miltiorrhizae 30 parts, Rhizoma Curcumae Longae 10 parts, Radix Tripterygii Wilfordii 10 parts, Herba Mimosae Pudicae 15 parts, Radix Curcumae 10 parts, Radix Glycyrrhizae Preparata 6 parts.

Preparation process:

The each taste Chinese medicine that will be weighed, decocts into decoction by traditional handicraft or Chinese patent medicine preparation processes routinely becomes Chinese Pharmacopoeia Defined in the clinical main Chinese patent medicine preparation such as tablet, pill, capsule, granule, powder or oral liquid.

Embodiment 2

Weigh Fructus Camptothecae Acuminatae 15 parts, Rhizoma Polygonati 15 parts, Herba Hedyotidis Diffusae 15 parts, Radix Bupleuri 5 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Curcumae Longae 5 Part, Radix Tripterygii Wilfordii 5, Herba Mimosae Pudicae 10 parts, Radix Curcumae 5 parts, Radix Glycyrrhizae Preparata 5 parts.

Preparation process is with embodiment 1.

Embodiment 3

Weigh Fructus Camptothecae Acuminatae 45 parts, Rhizoma Polygonati 45 parts, Herba Hedyotidis Diffusae 45 parts, Radix Bupleuri 15 parts, Radix Salviae Miltiorrhizae 40 parts, Rhizoma Curcumae Longae 15 parts, Radix Tripterygii Wilfordii 10, Herba Mimosae Pudicae 20 parts, Radix Curcumae 15 parts, Radix Glycyrrhizae Preparata 10 parts.

Preparation process is with embodiment 1.

Embodiment 4

Weigh Fructus Camptothecae Acuminatae 20 parts, Rhizoma Polygonati 25 parts, Herba Hedyotidis Diffusae 20 parts, Radix Bupleuri 9 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Curcumae Longae 9 Part, Radix Tripterygii Wilfordii 9, Herba Mimosae Pudicae 12 parts, Radix Curcumae 9 parts, Radix Glycyrrhizae Preparata 6 parts.

Preparation process is with embodiment 1.

Embodiment 5

Weigh Fructus Camptothecae Acuminatae 40 parts, Rhizoma Polygonati 40 parts, Herba Hedyotidis Diffusae 25 parts, Radix Bupleuri 12 parts, Radix Salviae Miltiorrhizae 40 parts, Rhizoma Curcumae Longae 12 parts, Radix Tripterygii Wilfordii 12, Herba Mimosae Pudicae 12 parts, Radix Curcumae 12 parts, Radix Glycyrrhizae Preparata 9 parts.

Preparation process is with embodiment 1.

Embodiment 6

Weigh Fructus Camptothecae Acuminatae 25 parts, Rhizoma Polygonati 35 parts, Herba Hedyotidis Diffusae 35 parts, Radix Bupleuri 10 parts, Radix Salviae Miltiorrhizae 25 parts, Rhizoma Curcumae Longae 9 parts, Radix Tripterygii Wilfordii 9, Herba Mimosae Pudicae 18 parts, Radix Curcumae 9 parts, Radix Glycyrrhizae Preparata 9 parts.

Preparation process is with embodiment 1.

Embodiment 7

Weigh Fructus Camptothecae Acuminatae 35 parts, Rhizoma Polygonati 25 parts, Herba Hedyotidis Diffusae 40 parts, Radix Bupleuri 9 parts, Radix Salviae Miltiorrhizae 35 parts, Rhizoma Curcumae Longae 12 parts, Radix Tripterygii Wilfordii 12, Herba Mimosae Pudicae 10 parts, Radix Curcumae 9 parts, Radix Glycyrrhizae Preparata 6 parts.

Preparation process is with embodiment 1.

Embodiment 8

Weigh Fructus Camptothecae Acuminatae 30 parts, Rhizoma Polygonati 40 parts, Herba Hedyotidis Diffusae 35 parts, Radix Bupleuri 6 parts, Radix Salviae Miltiorrhizae 45 parts, Rhizoma Curcumae Longae 6 Part, Radix Tripterygii Wilfordii 6, Herba Mimosae Pudicae 12 parts, Radix Curcumae 10 parts, Radix Glycyrrhizae Preparata 6 parts.

Preparation process is with embodiment 1.

Above content is only how the present invention implements example explanation, rather than protection scope of the present invention, institute Belong to various amendments or supplementary or that employing is similar side that described specific embodiment is made by those skilled in the art Formula substitute, without departing from invention structure or surmount scope defined in the claims, the present invention all should be belonged to Protection domain.

Claims (4)

1. treat a Chinese medicinal formulae for primary hepatocarcinoma, it is characterized in that being made up of the Chinese medicine of following weight portion:

Fructus Camptothecae Acuminatae 15-45 part, Rhizoma Polygonati 15-45 part, Herba Hedyotidis Diffusae 15-45 part, Radix Bupleuri 5-15 part, Radix Salviae Miltiorrhizae 15-45 Part, Rhizoma Curcumae Longae 5-15 part, Radix Tripterygii Wilfordii 5-15 part, Herba Mimosae Pudicae 10-20 part, Radix Curcumae 5-15 part, Radix Glycyrrhizae Preparata 5-10 Part.

The Chinese medicinal formulae for the treatment of primary hepatocarcinoma the most according to claim 1, is characterized in that by following weight portion Chinese medicine make:

Fructus Camptothecae Acuminatae 20-40 part, Rhizoma Polygonati 20-40 part, Herba Hedyotidis Diffusae 20-40 part, Radix Bupleuri 9-12 part, Radix Salviae Miltiorrhizae 20-40 Part, Rhizoma Curcumae Longae 9-12 part, Radix Tripterygii Wilfordii 9-12 part, Radix Curcumae 9-12 part, Herba Mimosae Pudicae 12-18 part, Radix Glycyrrhizae Preparata 5-10 Part.

The Chinese medicinal formulae for the treatment of primary hepatocarcinoma the most according to claim 1, is characterized in that by following weight portion Chinese medicine make:

Fructus Camptothecae Acuminatae 30 parts, Rhizoma Polygonati 30 parts, Herba Hedyotidis Diffusae 30 parts, Radix Bupleuri 10 parts, Radix Salviae Miltiorrhizae 30 parts, Rhizoma Curcumae Longae 10 Part, Radix Tripterygii Wilfordii 10, Herba Mimosae Pudicae 15 parts, Radix Curcumae 10 parts, Radix Glycyrrhizae Preparata 6 parts.

The Chinese medicinal formulae for the treatment of primary hepatocarcinoma the most according to claim 1 is for preparing primary hepatocarcinoma Application in primary formulation.