CN106177610A - A kind of ZHITONG GAO and preparation method thereof - Google Patents
A kind of ZHITONG GAO and preparation method thereof Download PDFInfo
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- CN106177610A CN106177610A CN201510219231.6A CN201510219231A CN106177610A CN 106177610 A CN106177610 A CN 106177610A CN 201510219231 A CN201510219231 A CN 201510219231A CN 106177610 A CN106177610 A CN 106177610A
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Abstract
The invention provides a kind of ZHITONG GAO and preparation method thereof, count by weight, by Radix Angelicae Sinensis 50～70 parts, Radix Angelicae Pubescentis 30～60 parts, Flos Carthami 30～50 parts, the Cortex Eucommiae 20～40 parts, Borneolum Syntheticum 20～40 parts, Herba Ephedrae 20～30 parts, Herba Glechomae 20～30 parts, Semen Momordicae 15～20 parts, the Radix Angelicae Dahuricae 15～20 parts, Rhizoma Chuanxiong 15～20 parts, Herba Lycopodii 15～20 parts, Radix Sophorae Flavescentis 15～20 parts, Semen Coicis 15～20 parts, Radix Et Rhizoma Rhei 10～15 parts, Cortex Cinnamomi 10～15 parts, Radix Salviae Miltiorrhizae 5～15 parts, Rhizoma Atractylodis 5～15 parts, Radix Glycyrrhizae 5～10 parts, Tween-80 50ml forms.Described drug component can reach reducing swelling and alleviating pain, good effect, the easy to use and beneficial effect that delays disease to occur.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, particularly relate to a kind of ZHITONG GAO and preparation method thereof.
Background technology
One of the most modal symptom is exactly pain, such as traumatic injury, rheumatism, rheumatoid, bone degeneration and a certain posture time
The long QI and blood caused is not lived, meridians are obstructed, joint, muscles and bones cervical carcinoma with cachexia, Acute and chronic inflammation etc. cause body swelling, pain.Especially
Being rheumatism, mostly be young and middle-aged, the difficult disease of old people, is due to wind, cold, wet, heat, waits exopathogen to attack human body, impatency meridians,
QI-blood circulation is the most freely caused, and with muscle, muscles and bones, ache in joint, numb, weighs, joint stuffiness, even arthroncus is burnt
Heat etc. are the disease of main clinical manifestation.Rheumatic arthritis can cause the biggest injury to patient, and serious meeting causes rheumatic heart disease,
And the psychology of patient be will also result in strike greatly, but if able to find the early symptom of rheumatic arthritis in time, control in time
If treatment, situation has the biggest change.But existing medication effect is unsatisfactory, in society, existing sick group is vast, to this kind of medicine and
Widespread demand is more there is in curative effect.
Summary of the invention
The present invention provides a kind of ZHITONG GAO and preparation method thereof, can reach reducing swelling and alleviating pain, the easy to use and beneficial effect that delays disease to occur.
Technical problem solved by the invention realizes by the following technical solutions:
A kind of ZHITONG GAO, counts by weight, by Radix Angelicae Sinensis 50～70 parts, Radix Angelicae Pubescentis 30～60 parts, Flos Carthami 30～50 parts, the Cortex Eucommiae 20～
40 parts, Borneolum Syntheticum 20～40 parts, Herba Ephedrae 20～30 parts, Herba Glechomae 20～30 parts, Semen Momordicae 15～20 parts, the Radix Angelicae Dahuricae 15～20 parts,
Rhizoma Chuanxiong 15～20 parts, Herba Lycopodii 15～20 parts, Radix Sophorae Flavescentis 15～20 parts, Semen Coicis 15～20 parts, Radix Et Rhizoma Rhei 10～15 parts, Cortex Cinnamomi 10～
15 parts, Radix Salviae Miltiorrhizae 5～15 parts, Rhizoma Atractylodis 5～15 parts, Radix Glycyrrhizae 5～10 parts, Tween-80 50ml forms.
The preparation method of above-mentioned ZHITONG GAO, concrete preparation process is as follows:
(1) by Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Flos Carthami, the Cortex Eucommiae, Borneolum Syntheticum, Herba Ephedrae, Herba Glechomae, Semen Momordicae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Herba Lycopodii is bitter
Ginseng, Semen Coicis, Radix Et Rhizoma Rhei, Cortex Cinnamomi, Radix Salviae Miltiorrhizae, Rhizoma Atractylodis and Radix Glycyrrhizae cleaning are dried, are ground into coarse powder, mix with 50mL Tween-80
In even addition 200ml distilled water, extract ingredient with extraction, remove extractant, obtain drug extract A；
(2) drug extract A is dissolved in 400ml distilled water, mix homogeneously, decocts 2 hours at 100 DEG C, leach；Again
Boil second time and add 800ml distilled water, decoct 4 hours at 100 DEG C, filter, concentrate, obtain concentrated solution B；
(3) being joined by concentrated solution C in the ethanol of 95%, make alcohol content reach 50%, precipitate with ethanol overnight, filters, filtrate recycling ethanol
Obtaining alcohol deposit fluid, reclaim ethanol, being concentrated into proportion is 1-1.02, prepares final concentrated solution D；
(4) by above-mentioned concentrated solution D sterilizing 1 hour at 120 DEG C, and the protection of whole process inflated with nitrogen；
(5) finally concentrated solution D is coated onto in tissue layer drying on superclean bench and obtains antiinflammatory blood circulation promoting and pain relieving plaster.
Described Radix Angelicae Sinensis: warm in nature, sweet in the mouth, pungent；Replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation, for blood deficiency and yellow complexion, dizziness cardiopalmus, the moon
Through uncomfortable, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Described Radix Angelicae Pubescentis: dry, relieving exterior syndrome and dispelling cold, expelling wind and dampness pungent, scattered, bitter, pain relieving.
Described Flos Carthami: pungent, warm, GUIXIN, Liver Channel, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain；For dysmenorrhea, lochia, lump in the abdomen painful abdominal mass is bad, fall and flutter damage
Wound, skin infection swells and ache.
The described Cortex Eucommiae: Gan Wen, returns liver, kidney channel, cures mainly invigorating the liver and kidney, and bone and muscle strengthening is antiabortive；For lumbago due to renal deficiency, muscles and bones is unable, high blood
Pressure.
Described Borneolum Syntheticum: refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Be applicable to calentura coma, convulsion is fainted, stagnation of QI sudden syncope, and attacked by pestiferous factors is gone into a coma, conjunctival congestion, aphtha,
Laryngopharynx swelling and pain, auditory meatus is suppurated.
Described Herba Ephedrae: hardship pungent, micro-, temperature, Gui Jing, return lung, bladder warp, cure mainly diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema；For
Anemofrigid cold, uncomfortable in chest breathes with cough, edema due to wind pathogen edema, bronchial asthma；It is used for table disease to solve, asthma and cough.
Described Herba Glechomae: bitter in the mouth, pungent, cool in nature, cures mainly dampness removing treating stranguria, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling；Main pyretic stranguria stranguria caused by urinary stone, jaundice due to damp-heat,
Sore, carbuncle and painful swelling, injury from falling down.
Described Semen Momordicae dispersing swelling and dissipating binds, toxic removing, control too fat to move, innominate toxic swelling, muscle arteries and veins contracture.
The described Radix Angelicae Dahuricae: dispel the wind, scorching, detumescence, pain relieving.
Described Rhizoma Chuanxiong: pungent, warm, returns liver, gallbladder, pericardium channel, blood-activating and qi-promoting, wind-expelling pain-stopping.
Described Herba Lycopodii: micro-hardship, pungent, warm, returns liver,spleen,kidney warp, expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral；For joint aches, bend and stretch not
Profit.
Described Radix Sophorae Flavescentis: heat clearing away, dampness, parasite killing.
Described Semen Coicis: exsiccation.
Described Radix Et Rhizoma Rhei: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
Described Cortex Cinnamomi: Xin Gan, heat, enter kidney, spleen, bladder warp；Complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation；Control decline of the fire from the gate of life,
Cold extremities faint pulse, YANG-depletion collapses, and stomachache has loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is floating more, on
Heat is lower cold.
Described Radix Salviae Miltiorrhizae: cold nature, bitter in the mouth, stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
Described Rhizoma Atractylodis: energy the meridian dredging, it is adaptable to rheumatic arthralgia, numb limbs and tense tendons, muscle arteries and veins contracture, joint joint stuffiness person.
Described Radix Glycyrrhizae heat-clearing and toxic substances removing, QI invigorating, lung moistening, and middle emergency, coordinating the actions of various ingredients in a prescription.
Described Tween-80 is a kind of conventional surfactant, and good hydrophilic property, is oil-in-water type, can use as emulsifying agent.
Preferably, a kind of ZHITONG GAO, count by weight, by Radix Angelicae Sinensis 50～60 parts, Radix Angelicae Pubescentis 30～50 parts, Flos Carthami 30～40 parts,
The Cortex Eucommiae 20～30 parts, Borneolum Syntheticum 20～30 parts, Herba Ephedrae 20～25 parts, Herba Glechomae 20～25 parts, Semen Momordicae 15～18 parts, the Radix Angelicae Dahuricae 15～
18 parts, Rhizoma Chuanxiong 15～18 parts, Herba Lycopodii 15～18 parts, Radix Sophorae Flavescentis 15～17 parts, Semen Coicis 15～17 parts, Radix Et Rhizoma Rhei 10～12 parts, meat
Osmanthus 10～12 parts, Radix Salviae Miltiorrhizae 5～10 parts, Rhizoma Atractylodis 5～10 parts, Radix Glycyrrhizae 5～8 parts, Tween-80 50ml forms.
Preferably, a kind of ZHITONG GAO, count by weight, by Radix Angelicae Sinensis 60 parts, Radix Angelicae Pubescentis 50 parts, 40 parts of Flos Carthami, the Cortex Eucommiae 30 parts, ice
Sheet 25 parts, 25 parts of Herba Ephedrae, Herba Glechomae 23 parts, Semen Momordicae 18 parts, the Radix Angelicae Dahuricae 18 parts, Rhizoma Chuanxiong 18 parts, Herba Lycopodii 17 parts, Radix Sophorae Flavescentis
17 parts, Semen Coicis 17 parts, Radix Et Rhizoma Rhei 12 parts, Cortex Cinnamomi 12 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Atractylodis 8 parts, 8 parts of Radix Glycyrrhizae, Tween-80 50ml
Composition.
The invention have the benefit that
1, the present invention can be done directly on injury, makes drug absorption rapid-onset, it is possible to ease the pain, resolution, thus row
Gas is had one's ideas straightened out, promoting the flow of QI in the collateral by warming the meridian, promoting blood circulation and stopping pain.
2, the present invention is affixed on the plaster stimulation teleneuron of body surface, by reflection, expands blood vessel, promotes local blood circulation, improves all
Enclose histotrophic nutrition, reach detumescence, antiinflammatory and analgesic purpose.
3, the dressing good stability of the present invention, simple to operate, cheap, is suitable for the needs that large-scale industrial produces.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of ZHITONG GAO, counts by weight, by Radix Angelicae Sinensis 50 parts, and Radix Angelicae Pubescentis 30 parts, 30 parts of Flos Carthami, the Cortex Eucommiae 20 parts, Borneolum Syntheticum 20 parts,
20 parts of Herba Ephedrae, Herba Glechomae 20 parts, Semen Momordicae 15 parts, the Radix Angelicae Dahuricae 15 parts, Rhizoma Chuanxiong 15 parts, Herba Lycopodii 15 parts, Radix Sophorae Flavescentis 15 parts, Job's tears
Core 15 parts, Radix Et Rhizoma Rhei 10 parts, Cortex Cinnamomi 10 parts, Radix Salviae Miltiorrhizae 5 parts, Rhizoma Atractylodis 5 parts, 5 parts of Radix Glycyrrhizae, Tween-80 50ml forms.
The preparation method of above-mentioned ZHITONG GAO, concrete preparation process is as follows:
(1) by Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Flos Carthami, the Cortex Eucommiae, Borneolum Syntheticum, Herba Ephedrae, Herba Glechomae, Semen Momordicae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Herba Lycopodii is bitter
Ginseng, Semen Coicis, Radix Et Rhizoma Rhei, Cortex Cinnamomi, Radix Salviae Miltiorrhizae, Rhizoma Atractylodis and Radix Glycyrrhizae cleaning are dried, are ground into coarse powder, mix with 50mL Tween-80
In even addition 200ml distilled water, extract ingredient with extraction, remove extractant, obtain drug extract A；
(2) drug extract A is dissolved in 400ml distilled water, mix homogeneously, decocts 2 hours at 100 DEG C, leach；Again
Boil second time and add 800ml distilled water, decoct 4 hours at 100 DEG C, filter, concentrate, obtain concentrated solution B；
(3) being joined by concentrated solution C in the ethanol of 95%, make alcohol content reach 50%, precipitate with ethanol overnight, filters, filtrate recycling ethanol
Obtaining alcohol deposit fluid, reclaim ethanol, being concentrated into proportion is 1-1.02, prepares final concentrated solution D；
(4) by above-mentioned concentrated solution D sterilizing 1 hour at 120 DEG C, and the protection of whole process inflated with nitrogen；
(5) finally concentrated solution D is coated onto in tissue layer drying on superclean bench and obtains antiinflammatory blood circulation promoting and pain relieving plaster.
Embodiment 2
A kind of ZHITONG GAO, counts by weight, by Radix Angelicae Sinensis 60 parts, and Radix Angelicae Pubescentis 50 parts, 40 parts of Flos Carthami, the Cortex Eucommiae 30 parts, Borneolum Syntheticum 25 parts,
25 parts of Herba Ephedrae, Herba Glechomae 23 parts, Semen Momordicae 18 parts, the Radix Angelicae Dahuricae 18 parts, Rhizoma Chuanxiong 18 parts, Herba Lycopodii 17 parts, Radix Sophorae Flavescentis 17 parts, Job's tears
Core 17 parts, Radix Et Rhizoma Rhei 12 parts, Cortex Cinnamomi 12 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Atractylodis 8 parts, 8 parts of Radix Glycyrrhizae, Tween-80 50ml forms.
The preparation method of above-mentioned ZHITONG GAO, concrete preparation process is as follows:
(1) by Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Flos Carthami, the Cortex Eucommiae, Borneolum Syntheticum, Herba Ephedrae, Herba Glechomae, Semen Momordicae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Herba Lycopodii is bitter
Ginseng, Semen Coicis, Radix Et Rhizoma Rhei, Cortex Cinnamomi, Radix Salviae Miltiorrhizae, Rhizoma Atractylodis and Radix Glycyrrhizae cleaning are dried, are ground into coarse powder, mix with 50mL Tween-80
In even addition 200ml distilled water, extract ingredient with extraction, remove extractant, obtain drug extract A；
(2) drug extract A is dissolved in 400ml distilled water, mix homogeneously, decocts 2 hours at 100 DEG C, leach；Again
Boil second time and add 800ml distilled water, decoct 4 hours at 100 DEG C, filter, concentrate, obtain concentrated solution B；
(3) being joined by concentrated solution C in the ethanol of 95%, make alcohol content reach 50%, precipitate with ethanol overnight, filters, filtrate recycling ethanol
Obtaining alcohol deposit fluid, reclaim ethanol, being concentrated into proportion is 1-1.02, prepares final concentrated solution D；
(4) by above-mentioned concentrated solution D sterilizing 1 hour at 120 DEG C, and the protection of whole process inflated with nitrogen；
(5) finally concentrated solution D is coated onto in tissue layer drying on superclean bench and obtains antiinflammatory blood circulation promoting and pain relieving plaster.
Embodiment 3
A kind of ZHITONG GAO, counts by weight, by Radix Angelicae Sinensis 70 parts, and Radix Angelicae Pubescentis 60 parts, 50 parts of Flos Carthami, the Cortex Eucommiae 40 parts, Borneolum Syntheticum 40 parts,
30 parts of Herba Ephedrae, Herba Glechomae 30 parts, Semen Momordicae 20 parts, the Radix Angelicae Dahuricae 20 parts, Rhizoma Chuanxiong 20 parts, Herba Lycopodii 20 parts, Radix Sophorae Flavescentis 20 parts, Job's tears
Core 20 parts, Radix Et Rhizoma Rhei 15 parts, Cortex Cinnamomi 15 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Atractylodis 15 parts, 10 parts of Radix Glycyrrhizae, Tween-80 50ml forms.
The preparation method of above-mentioned ZHITONG GAO, concrete preparation process is as follows:
(1) by Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Flos Carthami, the Cortex Eucommiae, Borneolum Syntheticum, Herba Ephedrae, Herba Glechomae, Semen Momordicae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Herba Lycopodii is bitter
Ginseng, Semen Coicis, Radix Et Rhizoma Rhei, Cortex Cinnamomi, Radix Salviae Miltiorrhizae, Rhizoma Atractylodis and Radix Glycyrrhizae cleaning are dried, are ground into coarse powder, mix with 50mL Tween-80
In even addition 200ml distilled water, extract ingredient with extraction, remove extractant, obtain drug extract A；
(2) drug extract A is dissolved in 400ml distilled water, mix homogeneously, decocts 2 hours at 100 DEG C, leach；Again
Boil second time and add 800ml distilled water, decoct 4 hours at 100 DEG C, filter, concentrate, obtain concentrated solution B；
(3) being joined by concentrated solution C in the ethanol of 95%, make alcohol content reach 50%, precipitate with ethanol overnight, filters, filtrate recycling ethanol
Obtaining alcohol deposit fluid, reclaim ethanol, being concentrated into proportion is 1-1.02, prepares final concentrated solution D；
(4) by above-mentioned concentrated solution D sterilizing 1 hour at 120 DEG C, and the protection of whole process inflated with nitrogen；
(5) finally concentrated solution D is coated onto in tissue layer drying on superclean bench and obtains antiinflammatory blood circulation promoting and pain relieving plaster.
Utilize technical solutions according to the invention, or those skilled in the art is under the inspiration of technical solution of the present invention, design similar
Technical scheme, and reach above-mentioned technique effect, all fall into protection scope of the present invention.
Claims (3)
1. ZHITONG GAO and preparation method thereof, it is characterised in that: count by weight, by Radix Angelicae Sinensis 50～70 parts, Radix Angelicae Pubescentis 30～60
Part, Flos Carthami 30～50 parts, the Cortex Eucommiae 20～40 parts, Borneolum Syntheticum 20～40 parts, Herba Ephedrae 20～30 parts, Herba Glechomae 20～30 parts, Semen Momordicae
Son 15～20 parts, the Radix Angelicae Dahuricae 15～20 parts, Rhizoma Chuanxiong 15～20 parts, Herba Lycopodii 15～20 parts, Radix Sophorae Flavescentis 15～20 parts, Semen Coicis 15～20
Part, Radix Et Rhizoma Rhei 10～15 parts, Cortex Cinnamomi 10～15 parts, Radix Salviae Miltiorrhizae 5～15 parts, Rhizoma Atractylodis 5～15 parts, Radix Glycyrrhizae 5～10 parts, Tween-80
50ml forms.
A kind of ZHITONG GAO the most according to claim 1 and preparation method thereof, it is characterised in that: count by weight, by Radix Angelicae Sinensis 50～
60 parts, Radix Angelicae Pubescentis 30～50 parts, Flos Carthami 30～40 parts, the Cortex Eucommiae 20～30 parts, Borneolum Syntheticum 20～30 parts, Herba Ephedrae 20～25 parts, even money
Grass 20～25 parts, Semen Momordicae 15～18 parts, the Radix Angelicae Dahuricae 15～18 parts, Rhizoma Chuanxiong 15～18 parts, Herba Lycopodii 15～18 parts, Radix Sophorae Flavescentis 15～
17 parts, Semen Coicis 15～17 parts, Radix Et Rhizoma Rhei 10～12 parts, Cortex Cinnamomi 10～12 parts, Radix Salviae Miltiorrhizae 5～10 parts, Rhizoma Atractylodis 5～10 parts, Radix Glycyrrhizae 5～
8 parts, Tween-80 50ml forms.
A kind of ZHITONG GAO the most according to claim 3 and preparation method thereof, it is characterised in that: count by weight, by Radix Angelicae Sinensis 60
Part, Radix Angelicae Pubescentis 50 parts, 40 parts of Flos Carthami, the Cortex Eucommiae 30 parts, Borneolum Syntheticum 25 parts, 25 parts of Herba Ephedrae, Herba Glechomae 23 parts, Semen Momordicae 18 parts, the Radix Angelicae Dahuricae 18
Part, Rhizoma Chuanxiong 18 parts, Herba Lycopodii 17 parts, Radix Sophorae Flavescentis 17 parts, Semen Coicis 17 parts, Radix Et Rhizoma Rhei 12 parts, Cortex Cinnamomi 12 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Atractylodis 8 parts,
8 parts of Radix Glycyrrhizae, Tween-80 50ml forms.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108992620A (en) * | 2018-08-31 | 2018-12-14 | 甘肃华药盛世生物科技有限公司 | A kind of bio-medical black plaster cold compress patch and preparation method thereof |
-
2015
- 2015-04-30 CN CN201510219231.6A patent/CN106177610A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108992620A (en) * | 2018-08-31 | 2018-12-14 | 甘肃华药盛世生物科技有限公司 | A kind of bio-medical black plaster cold compress patch and preparation method thereof |
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Application publication date: 20161207 |
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