CN106177254A - A kind of pharmaceutical composition treating sexual impotence - Google Patents
A kind of pharmaceutical composition treating sexual impotence Download PDFInfo
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- CN106177254A CN106177254A CN201610772635.2A CN201610772635A CN106177254A CN 106177254 A CN106177254 A CN 106177254A CN 201610772635 A CN201610772635 A CN 201610772635A CN 106177254 A CN106177254 A CN 106177254A
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- 208000010228 Erectile Dysfunction Diseases 0.000 title claims abstract description 31
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The invention discloses a kind of pharmaceutical composition treating sexual impotence, this pharmaceutical composition is made up of the crude drug of following weight parts: Anax parthenope Selys 40 50 parts, Bombycis mori 30 40 parts, Nidus Vespae 20 30 parts, Rhizoma Curculiginis 18 22 parts, Scolopendra 46 parts, Flos Caryophylli 14 16 parts, the Radix Aucklandiae 14 16 parts, Cortex Cinnamomi 14 16 parts, 79 parts of Fructus Piperis, raw Semen Ziziphi Spinosae 20 30 parts, Radix Angelicae Sinensis (processed with wine) 20 30 parts, the moxibustion Radix Polygoni Multiflori 20 30 parts, overcome the deficiency of existing treatment sexual impotence medicine, it is provided that one treats the preferable pharmaceutical composition of sexual impotence effect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition treating sexual impotence.
Background technology
Sexual impotence is due to congenital defect or to give up completely to natural impulse, sexual strain, or masturbation, early marriage, and vital essence all can be caused deficient, life
Door fire declines and causes impotence.In addition prolonged illness impairment caused by overstrain, undermines taste, and QI and blood source is not enough, can cause penis and lose to support and form sexual impotence etc.
A kind of disease of symptom.The traditional Chinese medical science thinks that sexual impotence and decline of the fire from the gate of life, fear are impairment of the kidney, deficiency of both the heart and spleen, depression of liver-QI, damp invasion of lower energizer etc. have
Close.
Existing a lot of oral external application Chinese medicine treating sexual impotence in the market, formula has complexity also to have simply, because of raw material
Medicine assemble difference, curative effect is the most each has something to recommend him.Existing oral Chinese medicine mostly is decoction, red medicine, because of the limit by substrate (carrier)
System, the past, but decoction often must be boiled medicine, the time was long then based on traditional decoction, and also to heat when second time is drunk and cause using
Inconvenient；Present then many based on pill, although the use of pill is more convenient, but the production cost of ball is higher, and its substrate
Drug loading is relatively low, and curative effect is also by a definite limitation.
Summary of the invention
The technical problem to be solved in the present invention is the deficiency overcoming existing treatment sexual impotence medicine, it is provided that a kind of prescription is simple,
Can life-time service and the treatment preferable pharmaceutical composition of sexual impotence effect.
In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries, by following heavy
The crude drug of amount part is made:
Anax parthenope Selys 40-50 part, Bombycis mori 30-40 part, Nidus Vespae 20-30 part, Rhizoma Curculiginis 18-22 part, Scolopendra 4-6 part, Flos Caryophylli
14-16 part, Radix Aucklandiae 14-16 part, Cortex Cinnamomi 14-16 part, Fructus Piperis 7-9 part, raw Semen Ziziphi Spinosae 20-30 part, Radix Angelicae Sinensis (processed with wine) 20-30 part, the moxibustion Radix Polygoni Multiflori
20-30 part.
Preferably, it is made up of the crude drug of following weight parts:
Anax parthenope Selys 45 parts, Bombycis mori 35 parts, Nidus Vespae 25 parts, Rhizoma Curculiginis 20 parts, Scolopendra 5 parts, Flos Caryophylli 15 parts, the Radix Aucklandiae 15 parts,
Cortex Cinnamomi 15 parts, 8 parts of Fructus Piperis, raw Semen Ziziphi Spinosae 25 parts, Radix Angelicae Sinensis (processed with wine) 25 parts, the moxibustion Radix Polygoni Multiflori 25 parts.
The dosage form of pharmaceutical composition of the present invention can be the medically acceptable agent such as capsule, pill, tablet, medicated wine
Type, their preparation method, supplementary product consumption are carried out by existing common process.
Pharmaceutical composition of the present invention is referred to art methods to be prepared, and prepares in accordance with the following methods, obtains
Effect is best:
Weigh the Anax parthenope Selys of formula ratio, Bombycis mori, Nidus Vespae (wine profit), Rhizoma Curculiginis, Scolopendra (wine profit), Flos Caryophylli, the Radix Aucklandiae, osmanthus
The heart, Fructus Piperis, raw Semen Ziziphi Spinosae, Radix Angelicae Sinensis (processed with wine), moxibustion Radix Polygoni Multiflori mix homogeneously, be polished into 180-300 mesh fine powder, be then charged into capsule.
Present invention additionally comprises aforementioned pharmaceutical compositions application in treatment sexual impotence medicine.
In prescription of the present invention:
Anax parthenope Selys, for the logical product taking a tonic or nourishing food to build up one's health body, among tonification, the property that outstanding tool is active, can enter kidney, superintend and direct, the liver pulse, use its flesh and blood
The high the kidney invigorating of in love body is superintended and directed the void of the liver pulse, is played flaccidity with tonifying YANG exhibition gesture.
Bombycis mori, for the logical product taking a tonic or nourishing food to build up one's health body, among tonification, the property that outstanding tool is active, can enter kidney, superintend and direct, the liver pulse, use its flesh and blood
The high the kidney invigorating of in love body is superintended and directed the void of the liver pulse, is played flaccidity with tonifying YANG exhibition gesture.
Nidus Vespae, property is sweet, flat, poisonous, dispels the wind, counteracting toxic substances, and parasite killing enters liver stomach kidney channel, for sexual impotence.
Rhizoma Curculiginis, has effect of kidney-replenishing, bone and muscle strengthening, dispelling cold and dampness.For sexual impotence cold sperm, muscles and bones flaccidity is soft, the cold numbness of waist knee joint, yang deficiency
Cold diarrhea.Rhizoma Curculiginis, slightly poisonous, the most preferably temporary takes soon.Rhizoma Curculiginis is kind mends gate of vitality's fire, and the hot violent cold relieving of property is appropriate.
Scolopendra, for medicinal herbs most in use, warm in nature, acrid in the mouth is poisonous.There is the function of endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
For infantile convulsion, tic spasm, apoplexy facial hemiparalysis, hemiplegia, tetanus disease, rheumatoid arthritis stubborn, skin infection, scrofula, poisonous snake
Bite.
Flos Caryophylli, meridian distribution of property and flavor is pungent, temperature.Return spleen, stomach, lung, kidney channel.Cure mainly: warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.
The Radix Aucklandiae, nature and flavor are pungent, bitter, temperature；Cure mainly promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, weight after dysentery, food stagnation is not
Disappear, anorexia.Radix Aucklandiae (roasted) reality intestinal antidiarrheal.For stomachache of having loose bowels.
Cortex Cinnamomi, property toil, function YANG invigorating, invigorate blood circulation.
Fructus Piperis, acrid in the mouth, property heat, enter stomach, large intestine channel；There are warming the middle warmer and descending qi, effect of expectorant removing toxic substances.
Semen Ziziphi Spinosae, nature and flavor are sweet, flat, nourishing the liver, and mind calming is calmed the nerves, arresting sweating.
Radix Angelicae Sinensis, enriches blood, invigorates blood circulation, menstruction regulating and pain relieving, moisturizes laxation；Radix Angelicae Sinensis (processed with wine), warm in nature, there is replenishing and activating blood, menstruction regulating and pain relieving, profit
Effect of intestinal relieving constipation.
Baked polygonum capitatum, energy tonifying liver, kidney tonifying, nourishes blood, dispels the wind.Can be used for hepatic and renal YIN deficiency, sending out must be the whitest, and blood deficiency is dizzy, and waist knee joint is soft
Weak, muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.
The above-mentioned ten mutual compatibilities of multi-flavor medicine, contribute to blood circulation, enhance metabolism, and have blood-enriching face-nourishing, relaxing muscles and tendons to live
Blood, body-building, effect of life lengthening, Synergistic, play effect of invigorating the liver and kidney tonifying YANG altogether, for impotence.
Detailed description of the invention
With specific embodiment, the invention will be further described below, but the invention is not limited in these embodiments.
Embodiment 1
Anax parthenope Selys 40g, Bombycis mori 40g, Nidus Vespae 20g, Rhizoma Curculiginis 22g, Scolopendra 4g, Flos Caryophylli 16g, Radix Aucklandiae 14g, Cortex Cinnamomi 16g,
Fructus Piperis 7g, raw Semen Ziziphi Spinosae 30g, Radix Angelicae Sinensis (processed with wine) 20g, moxibustion Radix Polygoni Multiflori 30g.
Weigh above each raw material by proportional quantity, smash, boiling twice, add 7 times amount water for the first time, decoct 1.5 hours,
Second time adds 8 times amount water, decocts 1.5 hours, collecting decoction, filters, and it is 1.30 (surveying when 70 DEG C) that filtrate is concentrated into relative density
Extractum, add appropriate adjuvant, technique makes tablet routinely.
Embodiment 2
Anax parthenope Selys 50g, Bombycis mori 30g, Nidus Vespae 30g, Rhizoma Curculiginis 18g, Scolopendra 6g, Flos Caryophylli 14g, Radix Aucklandiae 16g, Cortex Cinnamomi 14g,
Fructus Piperis 9g, raw Semen Ziziphi Spinosae 20g, Radix Angelicae Sinensis (processed with wine) 30g, moxibustion Radix Polygoni Multiflori 20g.
Weigh above each raw material by proportional quantity, smash, boiling twice, add 7 times amount water for the first time, decoct 1.5 hours,
Second time adds 8 times amount water, decocts 1.5 hours, collecting decoction, filters, and it is 1.30 (surveying when 70 DEG C) that filtrate is concentrated into relative density
Extractum, add appropriate adjuvant, technique makes granule routinely.
Embodiment 3
Anax parthenope Selys 45g, Bombycis mori 35g, Nidus Vespae 25g, Rhizoma Curculiginis 20g, Scolopendra 5g, Flos Caryophylli 15g, Radix Aucklandiae 15g, Cortex Cinnamomi 15g,
Fructus Piperis 8g, raw Semen Ziziphi Spinosae 25g, Radix Angelicae Sinensis (processed with wine) 25g, moxibustion Radix Polygoni Multiflori 25g.
Weigh the Anax parthenope Selys of formula ratio, Bombycis mori, Nidus Vespae (wine profit), Rhizoma Curculiginis, Scolopendra (wine profit), Flos Caryophylli, the Radix Aucklandiae, osmanthus
The heart, Fructus Piperis, raw Semen Ziziphi Spinosae, Radix Angelicae Sinensis (processed with wine), moxibustion Radix Polygoni Multiflori mix homogeneously, be polished into 200 mesh fine powders, be then charged into capsule.
Experimental example: the embodiment of the present invention 3 treats sexual impotence clinical observation on the therapeutic effect:
1, case and method
In June ,-2016 in January, 2012, in Qiezhou, institute of traditional Chinese medicine treats for impotence patient, patient 40 example, average year
45 years old age.
2, Therapeutic Method:
Example 3 obtains capsule, 0.5g/ grain, each 2, takes (on an empty stomach) with yellow wine, is used in conjunction 3-7 days, can according to the state of an illness
Continue 15 days.
3, efficacy determination
The course for the treatment of terminates, and curative effect is made by patient, and patient's record overcomes sexual impotence can carry out the time of effective sexual intercourse after taking medicine, with
And continue the time (ejaculation time delay is to sexual intercourse) of sexual intercourse.
4, result
Table 1: overcome sexual impotence can carry out the time of effective sexual intercourse after taking medicine
Table 2: continue the time of sexual intercourse
As a comparison, present invention applicant is the most respectively to Anax parthenope Selys, Bombycis mori, Rhizoma Curculiginis folk prescription, and Anax parthenope Selys and Jiu Run
Contrast test has been done in Nidus Vespae, Bombycis mori and wine profit Scolopendra, the combination of the Anax parthenope Selys Bombycis mori moxibustion Radix Polygoni Multiflori, and experimental result shows this
The effect of bright prescription is considerably beyond above contrast experiment's effect.
Experimental example:
1, Luo, man, 35 years old, people from Xixiangtang District, Nanning City.Suffer from sexual impotence more than 1 year, once take methyl testosterone, chorion
The gonadal hormone such as promoting sexual gland hormone, and many kidney-reinforcing Yang-strengthening Chinese medicine, all do not produce effects.Previously there is masturbation history, have sexual intercourse after marriage the most discontented
Meaning, accompanies psychentonia, soreness of waist frequent micturition, and blurring of vision accompanied with oppressive feeling is impatient, and arteries and veins is the most puckery.In January, 2012, use prescription of the present invention, take medicine 3 days
After, i.e. feel that penis has erection, first quarter moon is competing to be cured, and has sexual intercourse the most successful.Sexual impotence transference cure, uncomfortable without other.With preventing so far
Have no disease relapse.
2, Chen, man, 30 years old, Nanning Jiangnan District people from street.Suffer from sexual impotence more than 2 years, once use many kidney tonifying to strengthen
Sun Chinese medicine, does not all produce effects.Previously having masturbation history, have sexual intercourse after marriage the most dissatisfied, accompany psychentonia, soreness of waist frequent micturition, blurring of vision accompanied with oppressive feeling is impatient, arteries and veins
The most puckery.In May, 2012, use prescription of the present invention, after taking medicine 4 days, i.e. feel that penis has erection, competing after January is cured, the same branch of a family number
Secondary the most successful.Sexual impotence transference cure, uncomfortable without other.Have no recurrence the most always.
3, Huang, man, 28 years old, Nanning Jiangnan District people from street.Have sexual intercourse after marriage the most dissatisfied, the most unconsciously
Also can be hard, once take multiple kidney invigorating and YANG supporting Chinese medicine, have no effect.Increase and have masturbation history, accompany psychentonia, soreness of waist frequent micturition, fear of cold
Fear cold.In March, 2012, use prescription of the present invention, after taking medicine 3 days, i.e. feel that penis has erection, competing after 15 days is cured, have sexual intercourse
The most successful.Sexual impotence transference cure, uncomfortable without other.
4, Liu, man, 25 years old, Nanning Qingxiu District people from street.Sexual impotence half a year, once took in multiple kidney invigorating and YANG supporting
Medicine, has no effect.Increasing and have masturbation history, accompany psychentonia, soreness of waist frequent micturition, fear of cold fear is cold.In July, 2012, use this
Bright prescription, after taking medicine 3 days, i.e. feels that penis has erection, competing after 15 days is cured, has sexual intercourse the most successful.
5, what certain, man, 38 years old, Nanning Jiangnan District people from street.Suffering from sexual impotence 3 years, accompany sore waist and aching in the waist and the back, fear of cold fear is cold
Deng.Once take multiple kidney invigorating and YANG supporting Chinese medicine, have no effect.The suggestion of certain hospital is performed an operation.In March, 2012, use the present invention
Prescription, takes medicine after 10, i.e. feels that penis has erection, competing after 40 days is cured, and has sexual intercourse the most successful.
6, Deng, man, 31 years old, man, 38 years old, Nanning Jiangnan District people from street.Suffer from 2 year half a year of sexual impotence, companion's soreness of waist back of the body
Bitterly, fear of cold fear is cold etc..Once the gonadal hormone such as methyl testosterone, chorionic-gonadotropin hormone, and multiple kidney invigorating and YANG supporting Chinese medicine were taken, not
Take effect fruit.In June, 2012, use prescription of the present invention, take medicine after 7, i.e. feel that penis has erection, competing after 40 days be cured, have sexual intercourse
The most successful.City of south china people from Babu District.In February, 2012, believing that all hospital diagnosis is lumbar vertebra hyperosteogeny, symptom why
Sample？Cause leg pain, after hospitalization a period of time, have no improvement.In in December, 2012, use the present invention
The Chinese medicine that embodiment 3 prepares carries out hot compress (using method is as previously mentioned), hot compress every day 3 times, after using 50 days continuously, and various diseases
Shape disappears, uncomfortable without other.
7, beam, man, 31 years old, man, 38 years old, people from Yulin City of Guangxi Zhuang Autonomous.Suffering from 1 year half a year of sexual impotence, accompany sore waist and aching in the waist and the back, fear of cold fear is cold
Deng.Once take multiple kidney invigorating and YANG supporting Chinese medicine, but have no effect.In March, 2013, use prescription of the present invention, after taking medicine 10 days,
I.e. feel that penis has erection, competing after 45 days is cured, has sexual intercourse the most successful.
8, beam, man, 33 years old, man, 38 years old, Nanning Xixiangtang District people from street.Suffer from 2 year half a year of sexual impotence, accompany the soreness of waist
Backache, fear of cold fear is cold.Once the gonadal hormone such as methyl testosterone, chorionic-gonadotropin hormone, and multiple kidney invigorating and YANG supporting Chinese medicine were taken,
Have no effect.In October, 2012, use prescription of the present invention, after taking medicine 7 days, i.e. feel that penis has erection, competing after 45 days is cured,
Have sexual intercourse the most successful.
9, Wang, 25 years old, finds that vigorous number of times in morning gradually decreases, takes several days and could occur recovering after sexual life.Big in the past
There was masturbation phase in class hour, the most little after having object later, graduated from university the time the most more than a year, and sensation is substantially than university
Morning in period, vigorous number of times was few, and last time and girl friend's sexual life occur in that the most worried more hard phenomenon do not got up, and help lower half girl friend
Talent gets up firmly, also will not be hard when of sometimes seeing some adults.After sexual life, groin has a sour swollen symptom, and winter
Arriving, fear of cold fear is cold.
In February, 2013, use prescription of the present invention, after taking medicine 3 days, i.e. feel that penis has erection, competing after 15 days is cured, with
Room is the most successful.
10, to several long-term long-term receive excessive, the too much sexual life of sexual life is uncontrolled, the personnel of bad habit and behavior etc. are carried out
Test (name does not records), after treating 4 days with this prescription, takes a good rest, the sore waist and aching in the waist and the back transference cure felt at ordinary times, whole body sense
Feel the most comfortable.
Claims (3)
1. the pharmaceutical composition treating sexual impotence, it is characterised in that this pharmaceutical composition is by the crude drug of following weight parts
Make:
Anax parthenope Selys 40-50 part, Bombycis mori 30-40 part, Nidus Vespae 20-30 part, Rhizoma Curculiginis 18-22 part, Scolopendra 4-6 part, Flos Caryophylli 14-16
Part, Radix Aucklandiae 14-16 part, Cortex Cinnamomi 14-16 part, Fructus Piperis 7-9 part, raw Semen Ziziphi Spinosae 20-30 part, Radix Angelicae Sinensis (processed with wine) 20-30 part, moxibustion Radix Polygoni Multiflori 20-30
Part.
A kind of pharmaceutical composition treating sexual impotence the most according to claim 1, it is characterised in that this pharmaceutical composition be by
The crude drug of following weight parts is made:
Anax parthenope Selys 45 parts, Bombycis mori 35 parts, Nidus Vespae 25 parts, Rhizoma Curculiginis 20 parts, Scolopendra 5 parts, Flos Caryophylli 15 parts, the Radix Aucklandiae 15 parts, Cortex Cinnamomi
15 parts, 8 parts of Fructus Piperis, raw Semen Ziziphi Spinosae 25 parts, Radix Angelicae Sinensis (processed with wine) 25 parts, the moxibustion Radix Polygoni Multiflori 25 parts.
3. the application in the medicine of preparation treatment sexual impotence of the pharmaceutical composition according to any one of claim 1-2.
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| CN1559502A (en) * | 2004-02-18 | 2005-01-05 | 王秋如 | Chinese medicinal composition for treating sexual dysfunction |
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Application publication date: 20161207 |