CN106177228A - A kind of preparation and preparation method increasing knuckle synovia and repairing cartilage - Google Patents
A kind of preparation and preparation method increasing knuckle synovia and repairing cartilage Download PDFInfo
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Abstract
The present invention relates to health product technology field, specifically a kind of removing free radical, increase knuckle synovia, repair preparation and the preparation method of cartilage, it is characterized in that said preparation is by D glucosamine hydrochloride, Semen Vitis viniferae extract, chondroitin sulfate, astaxanthin, green tea extract, chlorella, algae extrats, vitamin C and starch composition, the weight proportion of above-mentioned each constituent is as follows: D glucosamine hydrochloride 50 90 parts, Semen Vitis viniferae extract 5 40 parts, chondroitin sulfate 20 40 parts, astaxanthin 5 25 parts, green tea extract 5 10 parts, chlorella 5 15 parts, algae extrats 5 10 parts, vitamin C 1 30 parts, starch 1 30 parts, there is removing free radical, increase knuckle synovia, repair the advantages such as cartilage.
Description
Technical field
The present invention relates to health product technology field, a kind of increase knuckle synovia that can remove free radical and repairing
The preparation of multiple cartilage and preparation method.
Background technology
It is known that immunity is a kind of defensive reaction that allosome material is occurred by body, it it is the distinctive a kind of mirror of body
Determine, identify, get rid of and eliminate the process of allosome material.Human immune system is divided into " specific immunity and nonspecific immunity " two
Kind, immune system is by the antibody secreted by various immunocytes and these cells and cytokine, and liver, spleen, lymph node, breast
The organ containing a large amount of leukocyte such as gland, bone marrow is formed.It is exactly that immune system has played defence capability that people recovers for illness without medical help sometimes.
Articular cartilage or " hyaline cartilage " of healthy vertebrates (including people and other mammals) are translucent breasts
White connective tissue, it is characterised in that the extracellular matrix (ECM) being mainly made up of Dan Baiduotang proteoglycan PG, II collagen type and water
The columnar growth pattern of middle chondrocyte.Articular cartilage provides effective load-bearing cushion pad to prevent in joint connecing between synthetism
Touch, and therefore most important to joint normal function.Articular cartilage is not only easily damaged by arthrotrauma, and is the most gradually corroded
Process is damaged.Initially, this erosion can the most asymptomatic " segment thickness defect (partial thickness defect
) ", the region that wherein hyaline cartilage reduces does not completely penetrates through to subchondral bone (subchondral bone).Described part
Thickness defect does not aches and generally only detects during arthroscopy.But, if not treating erosion process, then portion
The substrate dividing thickness defect can continue abrasion and Defect diameter can increase so that this defect finally develops into and penetrates lower floor's bone
" complete thickness defect (full thickness defect) ".This complete thickness defect can become sufficiently large so that joint pair
Bone surface becomes contact and starts to corrode each other, causes inflammation, pain and other degeneratioies, i.e. osteoarthritis (OA)
Classical symptom.Therefore osteoarthritis is to cause the degeneration of joint deformity, instability, damage and pain, Progressive symmetric erythrokeratodermia and disable
Disease.Osteoarthritis (OA) 1 also referred to as degenerative osteoarthritis, is most common disease in old people and overweight people.OA is to close
The disease of joint, but it is different from rheumatoid arthritis (RA), this disease is not systematic, the most only affects one or several
Joint, this disease causes total destruction of articular cartilage, the hardening of lower section bone, and hyperosteogeny to be formed, causes motor capacity to lose
Becoming estranged pain, final result needs total joint replacement often.
Summary of the invention
Present invention aim to address above-mentioned the deficiencies in the prior art, it is provided that a kind of increase knuckle synovia removing free radical
With preparation and the preparation method repairing cartilage.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of preparation increasing knuckle synovia and repairing cartilage, it is characterised in that said preparation is by D-Glucosamine Hydrochloride, Portugal
Grape seed extract, chondroitin sulfate, astaxanthin, green tea extract, chlorella, algae extrats, vitamin C and starch composition,
The weight proportion of above-mentioned each constituent is as follows: D-Glucosamine Hydrochloride 50-90 part, Semen Vitis viniferae extract 5-40 part, sulfur
Aching and limp ossein 20-40 part, astaxanthin 5-25 part, green tea extract 5-10 part, chlorella 5-15 part, algae extrats 5-10 part,
Vitamin C 1-30 part, starch 1-30 part.
In the present invention, the optimization weight ratio of each constituent of preparation is: D-Glucosamine Hydrochloride 60-70 part, Portugal
Grape seed extract 20-30 part, chondroitin sulfate 25-30 part, astaxanthin 10-15 part, green tea extract 6-7 part, chlorella 5-6
Part, algae extrats 8-9 part, Catergen 0-30 part, starch 15-25 part.
The preparation method of a kind of preparation increasing knuckle synovia and reparation cartilage, it is characterised in that its making step is as follows:
Step A: by D-Glucosamine Hydrochloride qualified for inspection, Semen Vitis viniferae extract, chondroitin sulfate, astaxanthin, green tea
Extract, chlorella, algae extrats, vitamin C, starch cross 80 mesh sieves respectively；
Step B: weigh the D-Glucosamine Hydrochloride of formula ratio, vitamin C, mixes (by formula by equal increments mixing method
Amount vitamin C with portion equivalent D-Glucosamine Hydrochloride repeatedly sieve (80 mesh) mix homogeneously, obtain mixed powder 1；Claim again
The a D-Glucosamine Hydrochloride with mixed powder 1 equivalent of amount, repeatedly sieves it with mixed powder 1 and mixs homogeneously；The most anti-
Multiple, until all mixing homogeneously with the D-Glucosamine Hydrochloride of formula ratio) uniformly, obtain mixed powder A；
Step C: weigh the Semen Vitis viniferae extract of formula ratio and mixed powder A equal increments mixing method mix homogeneously (by formula ratio
Semen Vitis viniferae extract repeatedly sieve with the mixed powder A of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 2；Weigh again a with
The mixed powder A of mixed powder 2 equivalent, repeatedly sieves it with mixed powder 2 and mixs homogeneously；The most repeatedly, until with whole mixed powder A
All mix homogeneously), obtain mixed powder B；
Step D: weigh the chondroitin sulfate of formula ratio and mixed powder B equal increments mixing method mix homogeneously (by formula ratio sulfur
Aching and limp ossein repeatedly sieve with the mixed powder B of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 3；Weigh portion and mix again
The mixed powder B of powder 3 equivalent, repeatedly sieves it with mixed powder 3 and mixs homogeneously；The most repeatedly, until the most mixed with whole mixed powder B
Close uniformly), obtain mixed powder C；
Step E: weigh the astaxanthin of formula ratio and mixed powder C equal increments mixing method mix homogeneously (by formula ratio astaxanthin
Repeatedly sieve with the mixed powder C of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 4；Weigh a and mixed powder 4 equivalent again
Mixed powder C, repeatedly sieves it with mixed powder 4 and mixs homogeneously；The most repeatedly, until all mixing homogeneously with whole mixed powder C),
Obtain mixed powder D；
Step F: the green tea extract and the mixed powder D equal increments mixing method mix homogeneously that weigh formula ratio are (green by formula ratio
Tea extract repeatedly sieve with the mixed powder D of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 5；Weigh portion and mix again
The mixed powder D of powder 5 equivalent, repeatedly sieves it with mixed powder 5 and mixs homogeneously；The most repeatedly, until the most mixed with whole mixed powder D
Close uniformly), obtain mixed powder E；
Step G: weigh the chlorella of formula ratio and mixed powder E equal increments mixing method mix homogeneously (by formula ratio chlorella
Repeatedly sieve with the mixed powder E of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 6；Weigh a and mixed powder 6 equivalent again
Mixed powder D, repeatedly sieves it with mixed powder 6 and mixs homogeneously；The most repeatedly, until all mixing homogeneously with whole mixed powder E),
Obtain mixed powder F；
Step H: weigh the algae extrats of formula ratio and mixed powder F equal increments mixing method mix homogeneously (by formula ratio salt
Algae extract repeatedly sieve with the mixed powder F of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 6；Weigh portion and mix again
The mixed powder F of powder 6 equivalent, repeatedly sieves it with mixed powder 6 and mixs homogeneously；The most repeatedly, until the most mixed with whole mixed powder F
Close uniformly), obtain mixed powder G；
Step I: the starch and the mixed powder G that weigh formula ratio mix 20 ~ 30min in three-dimensional mixer, obtain total mixed powder；
Step J: being filled by total mixed powder Autocapsulefillingmachine, capsule model is 1# capsule；
Step K: more populated capsule administration product buffing machine (model: YPT-II) is polished.
Due to the fact that containing D-Glucosamine Hydrochloride, Semen Vitis viniferae extract, chondroitin sulfate, astaxanthin, green tea
The formula such as extract, chlorella, algae extrats, vitamin C and starch, have removing free radical, increase knuckle synovia, reparation
The advantages such as cartilage.
Detailed description of the invention
A kind of preparation increasing knuckle synovia and repairing cartilage, it is characterised in that said preparation is by D-glucosamine hydrochloric acid
Salt, Semen Vitis viniferae extract, chondroitin sulfate, astaxanthin, green tea extract, chlorella, algae extrats, vitamin C and starch
Composition, the weight proportion of above-mentioned each constituent is as follows: D-Glucosamine Hydrochloride 50-90 part, Semen Vitis viniferae extract 5-40
Part, chondroitin sulfate 20-40 part, astaxanthin 5-25 part, green tea extract 5-10 part, chlorella 5-15 part, algae extrats 5-
10 parts, vitamin C 1-30 part, starch 1-30 part, optimization weight ratio is: D-Glucosamine Hydrochloride 60-70 part, Semen Vitis viniferae
Extract 20-30 part, chondroitin sulfate 25-30 part, astaxanthin 10-15 part, green tea extract 6-7 part, chlorella 5-6 part, salt
Algae extract 8-9 part, Catergen 0-30 part, starch 15-25 part, its making step is as follows: step A: by D-qualified for inspection
Glucosamine hydrochloride, Semen Vitis viniferae extract, chondroitin sulfate, astaxanthin, green tea extract, chlorella, algae extrats,
Vitamin C, starch cross 80 mesh sieves respectively.Step B: weigh the D-Glucosamine Hydrochloride of formula ratio, vitamin C, use equivalent
(repeatedly sieved by the D-Glucosamine Hydrochloride of formula ratio vitamin C with a equivalent (80 mesh) mixes to be incremented by mixing method mixing
Close uniformly, obtain mixed powder 1；Weigh a D-Glucosamine Hydrochloride with mixed powder 1 equivalent again, it is anti-with mixed powder 1
Sieve mix homogeneously again；The most repeatedly, until all mixing homogeneously with the D-Glucosamine Hydrochloride of formula ratio) uniformly, obtain mixed
Close powder A；Step C: weigh the Semen Vitis viniferae extract of formula ratio and mixed powder A equal increments mixing method mix homogeneously (by formula
Amount Semen Vitis viniferae extract with portion equivalent mixed powder A repeatedly sieve (80 mesh) mix homogeneously, obtain mixed powder 2；Weigh portion again
With the mixed powder A of mixed powder 2 equivalent, it is sieved repeatedly with mixed powder 2 and mixs homogeneously；The most repeatedly, until with all mix
Powder A all mix homogeneously), obtain mixed powder B；Step D: the chondroitin sulfate and the mixed powder B equal increments that weigh formula ratio mix
Method mix homogeneously (mix homogeneously, and obtains mixing by repeatedly sieved by the mixed powder B of formula ratio chondroitin sulfate with a equivalent (80 mesh)
Powder 3；Weigh a mixed powder B with mixed powder 3 equivalent again, it is sieved repeatedly with mixed powder 3 and mixs homogeneously；The most repeatedly,
Until all mixing homogeneously with whole mixed powder B), obtain mixed powder C；Step E: the astaxanthin and the mixed powder C that weigh formula ratio are used
The incremental mixing method mix homogeneously of amount (mixed powder C of formula ratio astaxanthin with a equivalent repeatedly sieved (80 mesh) mixs homogeneously,
Obtain mixed powder 4；Weigh a mixed powder C with mixed powder 4 equivalent again, it is sieved repeatedly with mixed powder 4 and mixs homogeneously；According to this
Repeatedly, until all mixing homogeneously with whole mixed powder C), obtain mixed powder D；Step F: weigh the green tea extract of formula ratio and mix
Close powder D equal increments mixing method mix homogeneously (repeatedly to be sieved by the mixed powder D of formula ratio green tea extract with a equivalent
(80 mesh) mix homogeneously, obtains mixed powder 5；Weigh a mixed powder D with mixed powder 5 equivalent again, by itself and mixed powder 5 mistake repeatedly
Sieve mix homogeneously；The most repeatedly, until all mixing homogeneously with whole mixed powder D), obtain mixed powder E；Step G: weigh formula ratio
Chlorella and mixed powder E are with equal increments mixing method mix homogeneously (by the mixed powder E of formula ratio chlorella and a equivalent repeatedly
Sieve (80 mesh) mix homogeneously, obtains mixed powder 6；Weigh a mixed powder D with mixed powder 6 equivalent again, it is anti-with mixed powder 6
Sieve mix homogeneously again；The most repeatedly, until all mixing homogeneously with whole mixed powder E), obtain mixed powder F；Step H: weigh formula
The algae extrats measured and mixed powder F equal increments mixing method mix homogeneously are (by formula ratio algae extrats and a equivalent
Mixed powder F repeatedly sieve (80 mesh) mix homogeneously, obtain mixed powder 6；Weigh a mixed powder F with mixed powder 6 equivalent again, will
It repeatedly sieves with mixed powder 6 and mixs homogeneously；The most repeatedly, until all mixing homogeneously with whole mixed powder F), obtain mixed powder G；
Step I: the starch and the mixed powder G that weigh formula ratio mix 20 ~ 30min in three-dimensional mixer, obtain total mixed powder；Step J: will
Total mixed powder Autocapsulefillingmachine is filled, and capsule model is 1# capsule；Step K: again by populated capsule administration product
Buffing machine (model: YPT-II) is polished.
D-Glucosamine Hydrochloride (D-Glucosamine Hydrochoride) in present component, chemistry is entitled
D-Glucosamine Hydrochloride, is a kind of derivant prepared by chitin, has important physiology to make to human body
With, glucosamine is the constituent of function macromole in the cell membrane such as human body glycoprotein, glycosaminoglycans, has in human body
Important physiological significance, it participates in Liver and kidney removing toxic substances, can play the effect at aspects such as antiinflammatory, hepatoprotective, enhancing immunity, up-to-date medical science
Research finds, lacks D-glucosamine and can directly result in the generation of various joint disease, and the process that D-glucosamine runs off is people in human body
One's mid-30s just has begun to, and D-glucosamine not only controls the osteoarticular health of human body, also control the generation of articular cartilage synovial membrane
Thanking to balance, D-glucosamine can expedite the emergence of and supplement knuckle synovia in a large number for human body, thus constantly lubricating joint cartilage surface, reduce abrasion, make
Joint part is nimbly and freely.Supplement enough knuckle synovias, also provide for articular cartilage, enough material carriers.D-glucosamine leads to
Crossing strong impulse chondrocyte, the collagen protein in synthesized human and hyaluronic acid, the joint that continuous reparation has been worn is soft
Bone, and new articular cartilage and synovial membrane can be generated, thus recover normal physiological function and the helpless function of joint part.
The damage of the articular chondrocytes caused simultaneously for long-term taking anti-inflammatory analgesic class medicine, it may have well repair work
With.D-glucosamine is in articular cavity " street cleaner ", can not only suppress the inflammatory reaction of nonspecific factor, releases pain, Er Qieneng
In eliminating articular cavity, harmful enzyme, improves joint and the immunity of body.Brought the raising of immunity by supplementary D-glucosamine, be to disappear
Important prerequisite except arthritis.
Semen Vitis viniferae extract in the present invention be from Semen Vitis viniferae extract a kind of human body in can not synthesize new and effective
Natural antioxidant material.It is the antioxidation found in current nature, the material that Scavenging ability is the strongest, its antioxygen
Changing activity is 50 times of vitamin E, ascorbic 20 times, and the free radical that it is unnecessary in effectively removing human body has superpower
Slow down aging and the effect of enhancing immunity.Antioxidation, antiallergic, resisting fatigue health invigorating, improve sub-health state and delay to decline
Always, the symptom such as irritable, dizzy weak, hypomnesis is improved.
Chondroitin sulfate (CS) in the present invention is that the covalently bound class osamine forming Dan Baiduotang proteoglycan PG on protein gathers
Sugar, chondroitin sulfate is distributed widely in extracellular matrix and the cell surface of animal tissue, and sugar chain is by glucuronic acid alternately
Form with N-acetylgalactosamine (also known as N-acetylamino galactosamine) disaccharide unit, be connected to core by one like sugar link zone
On the serine residue of heart protein, main application approach is the medicine as treatment joint disease, with amino Portugal
Grape sugar with the use of, there is pain relieving, promote effect of regenerating bone or cartilage, can be from improving joint prob at all, it is provided that pad
Effect, relaxes impact when taking action and friction, moisture can suck proteoglycan intramolecular, make cartilage thickening, and increase joint
Interior synovial fluid amount.One of critical function of chrondroitin is exactly as conveyance conduit, important oxygen for being delivered to pass with nutrient
Joint, helps to remove IA refuse, carbon dioxide and refuse is got rid of simultaneously.Supply owing to articular cartilage there is no blood
Should, the most all of oxygenation, nourishing and lubrication are all from synovial fluid, and chondroitin sulfate corneal collagen fiber have protection and make
With, the growth of fiber in substrate can be promoted, strengthen permeability, improve blood circulation, accelerate metabolism, promote the suction of penetrating fluid
Receive and the elimination of inflammation;Its polyanion has strong water-retaining property, can improve the water metabolism of corneal tissue, and corneal has relatively
Strong affinity, can form one layer of ventilative water-retaining film at anterior corneal surface, improve eye dryness symptom.By promoting the life of substrate
Become, the migration of framework, beneficially corneal epithelial cell is provided for the migration of cell, thus promotes the healing of corneal wound, ooze out
The absorption of liquid and the elimination of inflammation, its pass through high-tech deep processing, can treat nervous headache, trigeminal neuralgia, coronary heart disease,
The diseases such as angina pectoris, myocardial ischemia, cardiovascular and cerebrovascular disease, arthralgia, atherosclerosis and hepatitis, wherein CS also have anticoagulant and
Antithrombotic effect is it can also be used to the dysacousis and the impaired auxiliary of liver that cause because of streptomycin are treated and high
The auxiliary treatment of blood fat.
Astaxanthin in the present invention is the one of carotenoid, for a kind of stronger Natural antioxidant.With other classes recklessly
As Radix Raphani element, astaxanthin belongs to a kind of fat-soluble and water miscible pigment, and its anti-oxidation function is 500 times of vitamin E.Shrimp
Blue or green element has the effects such as protection skin and eyes, opposing radiation, cardiovascular Aging, senile dementia and cancer.The aging of human body, main
If the oxidation institute caused due to free radical is extremely.And the molecular configuration that Haematococcus Pluvialis extract is special, human body cell can be passed through
Outer wall, the oxygen-derived free radicals in direct scavenger cell, strengthen cell regeneration ability, maintain function of human body balance and reduce senile cell
Accumulation, protection cell and DNA are healthy from inside to outside, as the most efficient natural antioxidant of one, topmost function
It is to remove free radical, improves flight against senium of human body ability.
Green tea extract in the present invention is the active component extracted from green tea blade, mainly includes tea polyphenols etc., tool
There is antioxidation, remove the effects such as free radical.
Chlorella in the present invention is the green nourishing derived food of a kind of high-quality, and its main nutrient composition is even better than some
Main Foods, has the advantage that high protein, low fat, low sugar, low in calories and vitamin, Mineral element content are abundant, and
And there is some special medical health care, chlorella, mainly by improving the phagocytic activity of macrophage, promotes that lymph is thin
Dysuria with lower abdominal colic, increases lymphocyte number, and the vigor strengthening natural killer cell improves the immunity of body, the most several with following
Effect of active substance is relevant--chlorella growth factor (CGF): chlorella growth factor (chlorella growth
Factor, CGF), also it is chlorella extract, is cell active substance.Through toxicological experiment prove CGF be innocuous substance, therefore its
Additive as health product and functional food has broad prospects;Chlorella hot-water extraction thing (CVE);Chlorella polysaccharide;
Heterotrophism Chlorella pyrenoidesa, chlorella glycoprotein has antioxidation, can remove interior free yl.Free radical is human life
The intermediate product of movable mesophytization reaction, this includes ultra-oxygen anion free radical (O2) and hydroxy radical (OH) etc..
The TANZAOSU in algae extrats in the present invention be utilize modern means of science and technology to extract from salt alga, concentrate, essence
Make TANZAOSU, in TANZAOSU rich in the multiple natural carotenoid needed for health, folic acid, VitAVitE,
Linolenic acid, linoleic acid, lecithin, polysaccharide from Dunaliella salina, dietary fiber etc., the mineral of more than the 70 kind of needed by human body such as calcium, ferrum, zinc, selenium
And trace element, also rich in 18 kinds of aminoacid, wherein 8 kinds is needed by human, and the natural beta-carotin in TANZAOSU is medical science
The king of the antioxidation that boundary generally acknowledges, has the special construction of multiple conjugated polyene double bond, and this structure enables it to and oxygen radical
There is irreversible reaction, reach remove free radical and the effect of singlet-oxygen quenching and seizure and remove peroxylradicals.
Therefore beta-carotene is a kind of good free radical quencher, the namely terminator of free radical.
Vitamin C in the present invention is water soluble vitamins, and human body self can not synthesize, it is necessary to obtain VitC from meals.
Vitamin C is to maintain necessary to normal immunological function, the most supplementary, then improving immunocompetence.VitC promotes exempting from of body
Epidemic disease function machine is mainly manifested in following several respects: vitamin C is the necessary material maintaining body normal immunological function, in immunity
Play an important role in many important steps of mechanism.VitC can induce, promote that interferon (IFN) produces, thus strengthens cell and exempt from
Epidemic disease function.Vitamin C also can strengthen humoral immunization, participates in the generation of Ig, improves level of complement.Vitamin C also with leukocyte
Function is closely related.When VitC content in leukocyte reduces, body is the most infected.There is free miopragia in neutrophilic leukocyte
Or during sterilizing ability reduction, after giving VitC, then its free function and sterilizing ability are all improved.Thus enhance body
Anti-infection ability.Vitamin C is remarkably reinforced the phagocytic function of mononuclear cell and neutrophilic granulocyte, improves its bactericidal activity, promotes
Lymphocyte transformation and differentiation, promote antibody and the generation of complement.Vitamin C can significantly improve mice phagocytic function and pouring
Bar cell transformation rate.
The present invention is according to modern medical theory, and the mechanism improving immunity from many aspects carries out prescription.With D-in formula
Glucosamine hydrochloride is main, and glucosamine is the group of function macromole in the cell membrane such as human body glycoprotein, glycosaminoglycans
Become composition, high in human body internal absorption factor, there is important physiological significance.The advantage of glucosamine is its enhancing immunity
Mechanism of action is extensive and clear and definite: can remarkably promote the spleen lymphocyte proliferation ability of ConA induction, strengthens cellular immunization；Can strengthen
The non-specific immunity of mice, makes carbonic clearance ability significantly raised；The immunity of body after secondary sensitization can be improved, make late
Hair style allergy is obviously enhanced；It is remarkably improved the content of hemolysin in serum, promotes mice specific humoral immunity；Can promote
Enter the propagation of immunocyte, the ability of enhancing human body immunity response.It is auxiliary with Semen Vitis viniferae extract, on the other hand, former cyanine
Element has good antioxidation and removes the biological activity of free radical.The immune cell activation factor of composition can be made, especially
It is that interleukin system is more active.Machine interior free yl produces too much and/or removes the ability of free radical and declines, people's vivo oxidation and
Antioxidative is uneven, and oxidativestress damage is continuously increased, and the immunity of body declines the most therewith, causes cellular immunization and body fluid
Immunologic function weakens, and makes Immune discrimination power decline, and will increase the infection chance of various diseases.Take Semen Vitis viniferae extract
(procyanidin) can be obviously improved the reduction of leukocyte, increases the mobility of neutrophilic granulocyte, increases delayed-type hypersensitivity anti-
Should, stimulate lymphocytosis.Thus reach antioxidant stress injury, strengthen cellular immunization and the effect of humoral immunization.Help with
Vitamin C, the ability that vitamin C produces lymphocyte to lymphatic organs such as thymus, spleen, lymph nodes has a significant impact, and leads to
Cross the immunologic function of the raising enhancing body of antioxidant levels.Vitimin supplement C can promote Phagocytosis function.In serum, dimension is raw
Element C content is proportionate with IgG, IgM level, has an effect on disulfide formation between the clear chain of immunoglobulin, heavy chain.
It addition, Semen Vitis viniferae extract can be protected and stable vitamin C, take in procyanidin and vitamin C simultaneously, contribute to
Ascorbic absorption.And with produce cooperative effect, the immunity of mice and the opposing to resisiting influenza virus can be significantly improved
Power.So, vitamin C and the synergism of Semen Vitis viniferae extract, D-Glucosamine Hydrochloride many-side strengthens immunity in addition
Definite effect, make this product more effectively reach remove free radical, increase osteoarthrosis synovial fluid, repair cartilaginous tissue, strengthen immunity
The function of power.
Beneficial effects of the present invention, randomly selected the age more than 40 years old, clinical diagnosis be knee endoprosthesis scorching and verify
50 patients are carried out these goods by the knee pain patient of at least 15 days 50 in a middle of the month (each 25 of men and women) before the test
Taking, 50 patients take this goods, one day twice, once two, after taking one month, 50 patients carry out clinical inspection
Looking into, upon examination it is found that, in these 50 patients, the pain of 44 patients is substantially eased, and remaining six patients obtain slightly
Alleviating, and the immunity of this some patients is greatly improved, the clinical verification of logical excessive amount, these goods are for removing
Free radical, increase knuckle synovia, reparation cartilage have substantial effect.
Claims (3)
1. one kind increase knuckle synovia and repair cartilage preparation, it is characterised in that said preparation by D-Glucosamine Hydrochloride,
Semen Vitis viniferae extract, chondroitin sulfate, astaxanthin, green tea extract, chlorella, algae extrats, vitamin C and starch group
Becoming, the weight proportion of above-mentioned each constituent is as follows: D-Glucosamine Hydrochloride 50-90 part, Semen Vitis viniferae extract 5-40
Part, chondroitin sulfate 20-40 part, astaxanthin 5-25 part, green tea extract 5-10 part, chlorella 5-15 part, algae extrats 5-
10 parts, vitamin C 1-30 part, starch 1-30 part.
A kind of preparation increasing knuckle synovia and repairing cartilage the most according to claim 1, it is characterised in that preparation each
The optimization weight ratio of constituent is: D-Glucosamine Hydrochloride 60-70 part, Semen Vitis viniferae extract 20-30 part, sulphuric acid
Chrondroitin 25-30 part, astaxanthin 10-15 part, green tea extract 6-7 part, chlorella 5-6 part, algae extrats 8-9 part, dimension life
Element C20-30 part, starch 15-25 part.
3. the preparation method of the preparation increasing knuckle synovia and reparation cartilage, it is characterised in that its making step is as follows:
Step A: by D-Glucosamine Hydrochloride qualified for inspection, Semen Vitis viniferae extract, chondroitin sulfate, astaxanthin, green tea
Extract, chlorella, algae extrats, vitamin C, starch cross 80 mesh sieves respectively；
Step B: weigh the D-Glucosamine Hydrochloride of formula ratio, vitamin C, mixes (by formula by equal increments mixing method
Amount vitamin C with portion equivalent D-Glucosamine Hydrochloride repeatedly sieve (80 mesh) mix homogeneously, obtain mixed powder 1；Claim again
The a D-Glucosamine Hydrochloride with mixed powder 1 equivalent of amount, repeatedly sieves it with mixed powder 1 and mixs homogeneously；The most anti-
Multiple, until all mixing homogeneously with the D-Glucosamine Hydrochloride of formula ratio) uniformly, obtain mixed powder A；
Step C: weigh the Semen Vitis viniferae extract of formula ratio and mixed powder A equal increments mixing method mix homogeneously (by formula ratio
Semen Vitis viniferae extract repeatedly sieve with the mixed powder A of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 2；Weigh again a with
The mixed powder A of mixed powder 2 equivalent, repeatedly sieves it with mixed powder 2 and mixs homogeneously；The most repeatedly, until with whole mixed powder A
All mix homogeneously), obtain mixed powder B；
Step D: weigh the chondroitin sulfate of formula ratio and mixed powder B equal increments mixing method mix homogeneously (by formula ratio sulfur
Aching and limp ossein repeatedly sieve with the mixed powder B of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 3；Weigh portion and mix again
The mixed powder B of powder 3 equivalent, repeatedly sieves it with mixed powder 3 and mixs homogeneously；The most repeatedly, until the most mixed with whole mixed powder B
Close uniformly), obtain mixed powder C；
Step E: weigh the astaxanthin of formula ratio and mixed powder C equal increments mixing method mix homogeneously (by formula ratio astaxanthin
Repeatedly sieve with the mixed powder C of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 4；Weigh a and mixed powder 4 equivalent again
Mixed powder C, repeatedly sieves it with mixed powder 4 and mixs homogeneously；The most repeatedly, until all mixing homogeneously with whole mixed powder C),
Obtain mixed powder D；
Step F: the green tea extract and the mixed powder D equal increments mixing method mix homogeneously that weigh formula ratio are (green by formula ratio
Tea extract repeatedly sieve with the mixed powder D of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 5；Weigh portion and mix again
The mixed powder D of powder 5 equivalent, repeatedly sieves it with mixed powder 5 and mixs homogeneously；The most repeatedly, until the most mixed with whole mixed powder D
Close uniformly), obtain mixed powder E；
Step G: weigh the chlorella of formula ratio and mixed powder E equal increments mixing method mix homogeneously (by formula ratio chlorella
Repeatedly sieve with the mixed powder E of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 6；Weigh a and mixed powder 6 equivalent again
Mixed powder D, repeatedly sieves it with mixed powder 6 and mixs homogeneously；The most repeatedly, until all mixing homogeneously with whole mixed powder E),
Obtain mixed powder F；
Step H: weigh the algae extrats of formula ratio and mixed powder F equal increments mixing method mix homogeneously (by formula ratio salt
Algae extract repeatedly sieve with the mixed powder F of a equivalent (80 mesh) mix homogeneously, obtain mixed powder 6；Weigh portion and mix again
The mixed powder F of powder 6 equivalent, repeatedly sieves it with mixed powder 6 and mixs homogeneously；The most repeatedly, until the most mixed with whole mixed powder F
Close uniformly), obtain mixed powder G；
Step I: the starch and the mixed powder G that weigh formula ratio mix 20 ~ 30min in three-dimensional mixer, obtain total mixed powder；
Step J: being filled by total mixed powder Autocapsulefillingmachine, capsule model is 1# capsule；
Step K: more populated capsule administration product buffing machine (model: YPT-II) is polished.
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