CN106177101A - The new application at middle mongolian medicine shinyleaf yellowhorn fruit shell position - Google Patents
The new application at middle mongolian medicine shinyleaf yellowhorn fruit shell position Download PDFInfo
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- CN106177101A CN106177101A CN201510207708.9A CN201510207708A CN106177101A CN 106177101 A CN106177101 A CN 106177101A CN 201510207708 A CN201510207708 A CN 201510207708A CN 106177101 A CN106177101 A CN 106177101A
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- fruit shell
- shinyleaf yellowhorn
- yellowhorn fruit
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- gout
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- 244000248162 Xanthoceras sorbifolium Species 0.000 title claims abstract description 31
- 239000003814 drug Substances 0.000 title claims abstract description 31
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- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 28
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims abstract description 20
- 201000005569 Gout Diseases 0.000 claims abstract description 19
- 201000010099 disease Diseases 0.000 claims abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 13
- 230000002503 metabolic effect Effects 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 230000002265 prevention Effects 0.000 claims abstract description 6
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- 238000006297 dehydration reaction Methods 0.000 claims description 3
- 235000014347 soups Nutrition 0.000 claims description 2
- 238000010025 steaming Methods 0.000 claims description 2
- 206010018634 Gouty Arthritis Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 229940079593 drug Drugs 0.000 abstract description 4
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- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 11
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 10
- 229940116269 uric acid Drugs 0.000 description 10
- 208000002193 Pain Diseases 0.000 description 6
- 206010003246 arthritis Diseases 0.000 description 5
- 239000013078 crystal Substances 0.000 description 5
- 208000026816 acute arthritis Diseases 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000001503 joint Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 210000005239 tubule Anatomy 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000009084 Cold Injury Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 description 1
- 229960003459 allopurinol Drugs 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 210000000544 articulatio talocruralis Anatomy 0.000 description 1
- WHQCHUCQKNIQEC-UHFFFAOYSA-N benzbromarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(Br)=C(O)C(Br)=C1 WHQCHUCQKNIQEC-UHFFFAOYSA-N 0.000 description 1
- 229960002529 benzbromarone Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 231100000749 chronicity Toxicity 0.000 description 1
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- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
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- 230000002496 gastric effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
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- 210000000265 leukocyte Anatomy 0.000 description 1
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- 230000003908 liver function Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000007087 memory ability Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 210000000878 metatarsophalangeal joint Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 235000014102 seafood Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to drug world, particularly relate to shinyleaf yellowhorn fruit shell position purposes in the medicine of preparation treatment gout or prevention purine metabolic disturbance.Comprise the steps of: A. gather ripe clean and without blister, drench with rain, epidermis in green, without going mouldy, the residual shinyleaf yellowhorn fruit shell position of small holes caused by worms, agriculture；The most sliced, steam, make after drying and can extract or decoct and the Chinese crude drug used by unguentum.Beneficial effect: the present invention is in gout, the form brewed with shinyleaf yellowhorn fruit shell decoction pieces in the crowd of purine metabolic disturbance diseases gives clinical verification with the patient of oral wood of shiny-leaved yellowhorn, branch and leaf decoction and is contrasted, wherein the patients symptomatic of 95% alleviates or disappears, and do not find that toxic and side effects, effect become apparent from unexpectedly.
Description
Technical field
The present invention relates to drug world, particularly relate to middle mongolian medicine shinyleaf yellowhorn fruit shell position purposes in preparation treatment gout or prevention purine metabolic disturbance diseases medicine.
Background technology
Lignum Xanthoceratis (XanthocerassorbifoliaBunge.), it is that the distinctive oil of China is used and folk medicinal plants, find about the medicine pharmacology of Lignum Xanthoceratis and the scope of clinical practice according to " whole nation Chinese herbal medicine compilation ", " China's book on Chinese herbal medicine " etc., its all woody part and branch and leaf position with Lignum Xanthoceratis is used as medicine, for oral administration or external.Function cures mainly: expelling wind and removing dampness；Reducing swelling and alleviating pain.Main air damp-heat arthralgia；Bones and muscles pain.The entitled hila of mongolian medicine is gloomy to be stepped on, energy wind-damp dispelling, and reducing swelling and alleviating pain holds back yellow fluid reducing, is clinically used for treating the diseases such as rheumatic arthritis, rheumatism interior-heat, skin rheumatism.But shinyleaf yellowhorn fruit shell is the most often abandoned as discarded thing or burning, causes the significant wastage of efficient resource and the secondary pollution to environment.But current research direction only resides within the extraction process of saponin and the applied research aspect of chemical composition analysis and saponin active component.In addition to being found that Xanthoceraside has antioxidation, antitumor, loses weight, improves looks, improves memory ability effect, the application of other medicines is the most directionless.The traditional Chinese medical science thinks goutThe much more sick heresy damp and hot by diseases caused by exogenous pathogenic factor or the strongly fragrant long heat-transformation of heresy of wind and cold, or internal injury deficiency of the liver and kindey or arthromyodynia are with the passing of time, blood stasis stagnation of phlegm and cause.Though genus arthromyodynia, but its sharp ache, recurrent exerbation, touching do not heal, so that joint deformity, and have multiple complications, therefore again not in general arthromyodynia.Doctor trained in Western medicine is thoughtGout is deposited in a large number between joint by uric acid crystal thing and causes.Uric acid is a kind of inevitable metabolite in human body.Under normal circumstances, uric acid can be delivered to kidney by blood and excretes with urine.The uric acid of health excess, can form crystal, be deposited on intraarticular, cause severe pain.When human body serum Uric Acid Concentration is too high, uric acid is i.e. deposited in joint, soft tissue, cartilage and kidney with the form of sodium salt, causes the foreign body inflammation of tissue.Often occur at foot metatarsophalangeal joints, thumb joint or heel, instep, ankle joint or other joints, make affected joints generation twinge, the heating of short time inner skin is the most congested until arthroncus, peak is can reach in 24 hours, sharp ache, the lighter can free within a few hours be disappeared, and severe one to continue many days or a few week, and most gouts all can recur.As treated not in time, being then easily formed chronic, chronicity disease, and joint is caused permanent lesion, not only affect the orthobiosis of patient, working and learning, more serious harm patient's is healthy.And urate is a kind of white found in urine, tasteless crystal, it is practically insoluble in water, ethanol and ether, but is dissolved in basic salt.The medicine of existing treatment gout is such as: benzbromarone (skin graft immediately), and its main mechanism is to resist the renal tubules great absorption to uric acid, increases the renal tubules excretion to uric acid；Allopurinol, resists the generation of uric acid；This kind of medicine is often accompanied by gastrointestinal reaction diarrhoea, gastrointestinal upset, erythra, leukocyte and write platelet and reduce, liver function damage, the toxicity, side effects such as toxicity epithelium is downright bad, and, the most left alone without help medicine, have and can recur, it is impossible to radical cure.Compound recipe nerve capsule, although the hot stasis blocking wind-induced redness and swelling of joints of caused pain, heat pain can be treated, the diseases such as joint stuffiness, but period of taking medicine necessary the fasting sour and astringent and food of purine-containing of raw food, such as seafood, bean product and other nutriment etc., easily cause health malnutrition, resistance, immunity degradation and cause the adverse consequencess such as Other diseases.
It is a discovery of the invention that antioxidation, the antiphlogistic activity composition such as special composition Xanthoceraside contained by shinyleaf yellowhorn fruit shell and flavone not only can suppress the generation of metabolic arthritis sodium salt crystal, moreover it is possible to promote the eliminating of blood uric acid.The present invention verifies by clinic application, shinyleaf yellowhorn fruit shell has the nucleus formation of suppression metabolic arthritis sodium salt crystal, gout or purine metabolic disturbance diseases had good preventive and therapeutic action, for preparing treatment gout and the medicine of prevention purine metabolic disturbance diseases or health food and without any side effects to human body.The new application at Chinese medicine shinyleaf yellowhorn fruit shell position.
Summary of the invention
The purpose of invention: for the medicine effect providing a kind of medicine and emphasis to utilize shinyleaf yellowhorn fruit shell position.
In order to reach as above purpose, the present invention adopts the following technical scheme that:
Scheme one:
Shinyleaf yellowhorn fruit shell position purposes in preparation treatment gout medicine or health food.
Scheme two:
Shinyleaf yellowhorn fruit shell position purposes in preparation prevention purine metabolic disturbance diseases medicine or health food.
Scheme three: the medicine for the treatment of gout, it is characterised in that comprise the steps of:
A gather ripe clean and without blister, drench with rain, epidermis in green, without going mouldy, the residual shinyleaf yellowhorn fruit shell position of small holes caused by worms, agriculture；
B is sliced, steam, make after drying and can extract or decoct soup or brew tablet used.
1. the further technical scheme of the present invention is, described in steam and refer to be placed on shinyleaf yellowhorn fruit shell half an hour in steam ambient.Be dried refer to be placed in by shinyleaf yellowhorn fruit shell in 40-50 degree Celsius of environment dehydration system do to moisture content be not more than 6% dry product.
Use the present invention of as above technical scheme, have the advantages that relative to prior art: the present invention is in gout, the form brewed with shinyleaf yellowhorn fruit shell decoction pieces in the crowd of purine metabolic disturbance diseases gives clinical verification with the patient of oral wood of shiny-leaved yellowhorn, branch and leaf decoction and is contrasted, wherein: suffer from the patient of gout and gouty acute arthritis to part and wood of shiny-leaved yellowhorn, branch and leaf decoction be directly administered orally, but effect inconspicuous.The present invention has seen and treated patients the patient nearly ten thousand of gout and gouty acute arthritis since 2010 altogether and the form that all brews with shinyleaf yellowhorn fruit shell decoction pieces finds for patient is oral, the curative competence of the clinical effectiveness of the present invention is more than 95%, and do not find that toxic and side effects, effect become apparent from unexpectedly.
Detailed description of the invention
Illustrating embodiments of the invention below, embodiment is not construed as limiting the invention:
Shinyleaf yellowhorn fruit shell part purposes in preparation treatment gout medicine or health food.
Shinyleaf yellowhorn fruit shell part purposes in preparation prevention purine metabolic disturbance diseases medicine or health food.
The medicine for the treatment of gout, it is characterised in that comprise the steps of:
A gather ripe clean and without blister, drench with rain, epidermis is in green, without the residual shinyleaf yellowhorn fruit shell position of small holes caused by worms of going mouldy, agriculture；
B is sliced, steam, make the tablet that can extract or used by decoct after drying.
2. the further technical scheme of the present invention is, described aerating steaming and decocting refers to that Lignum Xanthoceratis is crossed shell is placed on half an hour in steam ambient.Be dried refer to be placed in by shinyleaf yellowhorn fruit shell in 40-50 degree Celsius of environment dehydration system do to moisture content be not more than 6% dry product.
The substantive distinguishing features of the present invention can be found out by following: the present invention has seen and treated patients the patient nearly ten thousand of gout and gouty acute arthritis since 20010 altogether and the form that all brews with shinyleaf yellowhorn fruit shell decoction pieces finds for patient is oral, the curative competence of the clinical effectiveness of the present invention is more than 95%, and do not find that toxic and side effects, effect become apparent from unexpectedly.
Clinical experiment report (part)
The ultimate principle of the present invention, principal character and advantages of the present invention have more than been shown and described.Those skilled in the art is it should be recognized that the present invention is not restricted to the described embodiments; the principle that the present invention is simply described described in above-described embodiment and description; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements both fall within claimed scope.
Claims (4)
1. shinyleaf yellowhorn fruit shell position purposes in preparation treatment gout and gouty arthritis medicine or health food.
2. shinyleaf yellowhorn fruit shell position purposes in preparation prevention purine metabolic disturbance diseases medicine or health food.
3. treat the medicine of gout, it is characterised in that comprise the steps of:
A gather ripe clean and without blister, drench with rain, epidermis in green, without going mouldy, the residual shinyleaf yellowhorn fruit shell of small holes caused by worms, agriculture；
B is sliced, steam, make after drying and can extract or decoct soup or brew tablet used.
4. the medicine treating gout as claimed in claim 3, it is characterized in that, described steaming refers to be placed on shinyleaf yellowhorn fruit shell half an hour in steam ambient, be dried refer to be placed in by shinyleaf yellowhorn fruit shell in 40-50 degree Celsius of environment dehydration system do to moisture content be not more than 6% dry product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510207708.9A CN106177101A (en) | 2015-04-29 | 2015-04-29 | The new application at middle mongolian medicine shinyleaf yellowhorn fruit shell position |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510207708.9A CN106177101A (en) | 2015-04-29 | 2015-04-29 | The new application at middle mongolian medicine shinyleaf yellowhorn fruit shell position |
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| Publication Number | Publication Date |
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| CN106177101A true CN106177101A (en) | 2016-12-07 |
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| CN201510207708.9A Pending CN106177101A (en) | 2015-04-29 | 2015-04-29 | The new application at middle mongolian medicine shinyleaf yellowhorn fruit shell position |
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| CN (1) | CN106177101A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018718A (en) * | 2010-12-06 | 2011-04-20 | 杨柏珍 | Application of Xanthoceraside compound |
| CN102793647A (en) * | 2012-09-04 | 2012-11-28 | 山东理工大学 | Method for extracting shinyleaf yellowhorn flavone substance and application of shinyleaf yellowhorn flavone substance in anti-aging industry |
| CN102796067A (en) * | 2012-09-04 | 2012-11-28 | 山东理工大学 | Method for extracting flavonoids from xanthoceras sorbifolia shells |
| CN101810715B (en) * | 2009-02-24 | 2013-04-17 | 成都中医药大学附属医院 | New application of fructus evodiae and extracts and compounds thereof |
| CN104258209A (en) * | 2014-09-25 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | External medicinal liquor for treating gout and preparation method thereof |
| CN104473157A (en) * | 2014-11-25 | 2015-04-01 | 马绍两 | Application of flavone extract of xanthoceras sorbifolia in sugar-reducing and fat-reducing fields and extraction method of flavone extract |
-
2015
- 2015-04-29 CN CN201510207708.9A patent/CN106177101A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810715B (en) * | 2009-02-24 | 2013-04-17 | 成都中医药大学附属医院 | New application of fructus evodiae and extracts and compounds thereof |
| CN102018718A (en) * | 2010-12-06 | 2011-04-20 | 杨柏珍 | Application of Xanthoceraside compound |
| CN102793647A (en) * | 2012-09-04 | 2012-11-28 | 山东理工大学 | Method for extracting shinyleaf yellowhorn flavone substance and application of shinyleaf yellowhorn flavone substance in anti-aging industry |
| CN102796067A (en) * | 2012-09-04 | 2012-11-28 | 山东理工大学 | Method for extracting flavonoids from xanthoceras sorbifolia shells |
| CN104258209A (en) * | 2014-09-25 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | External medicinal liquor for treating gout and preparation method thereof |
| CN104473157A (en) * | 2014-11-25 | 2015-04-01 | 马绍两 | Application of flavone extract of xanthoceras sorbifolia in sugar-reducing and fat-reducing fields and extraction method of flavone extract |
Non-Patent Citations (1)
| Title |
|---|
| 夏道宗等: ""黄酮类化合物防治高尿酸血症和痛风的研究进展"", 《中国药学杂志》 * |
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Effective date of registration: 20171227 Address after: 722300 Baoji province Shaanxi City West Town Village a group of Meixian huaiya No. 065 Applicant after: Shi Haiquan Address before: 730900 Baiyin, Baiyin District, Gansu Lan Bao Road, No. 333 (08) 1-01 (incubator base) Applicant before: Gansu Long Raven's Crown Fruit Industry Development Co. Ltd. |
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