CN106176593A - A kind of eye drip Rimactane and preparation method thereof - Google Patents

A kind of eye drip Rimactane and preparation method thereof Download PDF

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Publication number
CN106176593A
CN106176593A CN201610744871.3A CN201610744871A CN106176593A CN 106176593 A CN106176593 A CN 106176593A CN 201610744871 A CN201610744871 A CN 201610744871A CN 106176593 A CN106176593 A CN 106176593A
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Prior art keywords
gram
rimactane
reagent
grams
eye drip
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CN201610744871.3A
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Chinese (zh)
Inventor
王殿阔
葛长城
吴磊
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Anhui Aikeer Pharmaceutical Co Ltd
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Anhui Aikeer Pharmaceutical Co Ltd
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Priority to CN201610744871.3A priority Critical patent/CN106176593A/en
Publication of CN106176593A publication Critical patent/CN106176593A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/22Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a kind of eye drip Rimactane; its raw material is as follows: rifampicin 8 10 grams; 0.3 0.5 grams of sodium chloride; Borneolum Syntheticum 23 grams, sodium dihydrogen phosphate 1 1.5 grams, disodium hydrogen phosphate 1 1.3 grams; boric acid 0.5 0.8 grams; disodiumedetate 0.6 0.8 grams, taurine 0.1 0.2 grams, water for injection 80 100 milliliters.A kind of eye drip Rimactane that the present invention provides and preparation method thereof, make collyrium can obtain the effect of good fatigue alleviating by the mixing of Multiple components, there is higher bactericidal antiphlogistic effect simultaneously, effectively the pathogenic bacteria infected can be eliminated, ocular disease is effectively eliminated.

Description

A kind of eye drip Rimactane and preparation method thereof
Technical field
The present invention relates to eye drop technical field, particularly relate to a kind of eye drip Rimactane and preparation method thereof.
Background technology
Collyrium is the liquid medicine for the treatment of disease of eye, and its composition has numerous species according to the difference of effect, such as steroid, anti- Raw element, antihistaminic, beta-blocker, non-steroidal anti-inflammatory analgesic etc..General collyrium with the addition of to preserve for a long time The preservative of trace, will not impact human body under normal use.If but life-time service contains the collyrium of preservative, relatively Easily cause cornea injured, the symptoms such as one's eyes became bloodshot, photophobia occur.Different collyrium has respective purposes, such as, treat eye Eyeball infection, reduction intraocular pressure, anti-inflammatory analgetic or eyes of releiving are dry and astringent.Such as other drug, many collyrium all have some degree Side effect.Rifampicin is semi-synthetic wide-spectrum bactericide, with the β subunit strong bonded of the RNA polymerase depending on DNA, suppression The synthesis of bacteria RNA, prevents this enzyme to be connected with DNA, thus blocks rna transcription process.Rifampicin has well for collyrium Effect, eye can well be eliminated, have good bactericidal effect.
Summary of the invention
The invention aims to solve shortcoming present in prior art, and a kind of eye drip rifampicin system proposed Agent and preparation method thereof.
To achieve these goals, present invention employs following technical scheme:
A kind of eye drip Rimactane, its raw material is as follows: rifampicin 8-10 gram, 0.3-0.5 gram of sodium chloride, Borneolum Syntheticum 2-3 gram, sodium dihydrogen phosphate 1-1.5 gram, disodium hydrogen phosphate 1-1.3 gram, boric acid 0.5-0.8 gram, disodiumedetate 0.6- 0.8 gram, taurine 0.1-0.2 gram, water for injection 80-100 milliliter.
Preferably, described Borneolum Syntheticum is the powder after grinding, and powder mesh number is 800 mesh.
Preferably, described disodium hydrogen phosphate and sodium dihydrogen phosphate are anhydrous state.
The preparation method of a kind of eye drip Rimactane, comprises the steps:
The preparation of S1: reagent bottle, carries out sterilization treatment by reagent bottle at high-temperature steam cabinet, and being then dried process can make With;
S2: by rifampicin, sodium chloride, Borneolum Syntheticum, sodium dihydrogen phosphate, disodium hydrogen phosphate, boric acid, disodiumedetate, cattle sulphur Acid and water for injection join and carry out in reagent bottle dissolving mixing, it is thus achieved that mix reagent, use water-bath during dissolving mixing The mode of heating, bath temperature controls between 50-60 degree Celsius;
S3: fine straining processes, and the mix reagent obtained in S2 is carried out in defecator filtration treatment, and the mesh number of drainage screen is 800 mesh, need mix reagent is rocked vibrations, it is to avoid some precipitations caused in fine straining processing procedure simultaneously Filter is not exclusively;
S4: sterilization treatment, uses the mode of high-temp steam sterilizing, is put into by mix reagent in high-temperature steam cabinet and carry out at sterilizing Reason, sterilization time is at least 30 minutes;
S5: Detection, detects the mix reagent via high-temp steam sterilizing, examines after taking out reagent on detection equipment Survey, thus learn whether sterilizing reaches standard;
S6: sub-bottle packaging, is vacuum-packed in the vial by detecting qualified mix reagent through S5.
A kind of eye drip Rimactane that the present invention provides and preparation method thereof, makes eye by the mixing of Multiple components Liquid medicine can obtain the effect of good fatigue alleviating, has higher bactericidal antiphlogistic effect simultaneously, can be effectively by infection Pathogenic bacteria eliminates, and is effectively eliminated by ocular disease.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with specific embodiment, to this Invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, not For limiting the present invention.
Embodiment 1
A kind of eye drip Rimactane, its raw material is as follows: rifampicin 8 grams, 0.3 gram of sodium chloride, Borneolum Syntheticum 2 grams, phosphorus 1 gram of acid dihydride sodium, disodium hydrogen phosphate 1 gram, boric acid 0.5 gram, disodiumedetate 0.6 gram, taurine 0.1 gram, injection 80 milliliters of water.
Described Borneolum Syntheticum is the powder after grinding, and powder mesh number is 800 mesh.
Described disodium hydrogen phosphate and sodium dihydrogen phosphate are anhydrous state.
The preparation method of a kind of eye drip Rimactane, comprises the steps:
The preparation of S1: reagent bottle, carries out sterilization treatment by reagent bottle at high-temperature steam cabinet, and being then dried process can make With;
S2: by rifampicin, sodium chloride, Borneolum Syntheticum, sodium dihydrogen phosphate, disodium hydrogen phosphate, boric acid, disodiumedetate, cattle sulphur Acid and water for injection join and carry out in reagent bottle dissolving mixing, it is thus achieved that mix reagent, use water-bath during dissolving mixing The mode of heating, bath temperature controls between 50-60 degree Celsius;
S3: fine straining processes, and the mix reagent obtained in S2 is carried out in defecator filtration treatment, and the mesh number of drainage screen is 800 mesh, need mix reagent is rocked vibrations, it is to avoid some precipitations caused in fine straining processing procedure simultaneously Filter is not exclusively;
S4: sterilization treatment, uses the mode of high-temp steam sterilizing, is put into by mix reagent in high-temperature steam cabinet and carry out at sterilizing Reason, sterilization time is at least 30 minutes;
S5: Detection, detects the mix reagent via high-temp steam sterilizing, examines after taking out reagent on detection equipment Survey, thus learn whether sterilizing reaches standard;
S6: sub-bottle packaging, is vacuum-packed in the vial by detecting qualified mix reagent through S5.
Embodiment 2
A kind of eye drip Rimactane, its raw material is as follows: rifampicin 9 grams, 0.4 gram of sodium chloride, Borneolum Syntheticum 2.5 grams, Sodium dihydrogen phosphate 1.25 grams, disodium hydrogen phosphate 1.15 grams, boric acid 0.7 gram, disodiumedetate 0.7 gram, taurine 0.15 Gram, water for injection 90 milliliters.
Described Borneolum Syntheticum is the powder after grinding, and powder mesh number is 800 mesh.
Described disodium hydrogen phosphate and sodium dihydrogen phosphate are anhydrous state.
The preparation method of a kind of eye drip Rimactane, comprises the steps:
The preparation of S1: reagent bottle, carries out sterilization treatment by reagent bottle at high-temperature steam cabinet, and being then dried process can make With;
S2: by rifampicin, sodium chloride, Borneolum Syntheticum, sodium dihydrogen phosphate, disodium hydrogen phosphate, boric acid, disodiumedetate, cattle sulphur Acid and water for injection join and carry out in reagent bottle dissolving mixing, it is thus achieved that mix reagent, use water-bath during dissolving mixing The mode of heating, bath temperature controls between 50-60 degree Celsius;
S3: fine straining processes, and the mix reagent obtained in S2 is carried out in defecator filtration treatment, and the mesh number of drainage screen is 800 mesh, need mix reagent is rocked vibrations, it is to avoid some precipitations caused in fine straining processing procedure simultaneously Filter is not exclusively;
S4: sterilization treatment, uses the mode of high-temp steam sterilizing, is put into by mix reagent in high-temperature steam cabinet and carry out at sterilizing Reason, sterilization time is at least 30 minutes;
S5: Detection, detects the mix reagent via high-temp steam sterilizing, examines after taking out reagent on detection equipment Survey, thus learn whether sterilizing reaches standard;
S6: sub-bottle packaging, is vacuum-packed in the vial by detecting qualified mix reagent through S5.
Embodiment 3
A kind of eye drip Rimactane, its raw material is as follows: rifampicin 10 grams, 0.5 gram of sodium chloride, Borneolum Syntheticum 3 grams, phosphorus 1.5 grams of acid dihydride sodium, disodium hydrogen phosphate 1.3 grams, boric acid 0.8 gram, disodiumedetate 0.8 gram, taurine 0.2 gram, note Penetrate with 100 milliliters of water.
Described Borneolum Syntheticum is the powder after grinding, and powder mesh number is 800 mesh.
Described disodium hydrogen phosphate and sodium dihydrogen phosphate are anhydrous state.
The preparation method of a kind of eye drip Rimactane, comprises the steps:
The preparation of S1: reagent bottle, carries out sterilization treatment by reagent bottle at high-temperature steam cabinet, and being then dried process can make With;
S2: by rifampicin, sodium chloride, Borneolum Syntheticum, sodium dihydrogen phosphate, disodium hydrogen phosphate, boric acid, disodiumedetate, cattle sulphur Acid and water for injection join and carry out in reagent bottle dissolving mixing, it is thus achieved that mix reagent, use water-bath during dissolving mixing The mode of heating, bath temperature controls between 50-60 degree Celsius;
S3: fine straining processes, and the mix reagent obtained in S2 is carried out in defecator filtration treatment, and the mesh number of drainage screen is 800 mesh, need mix reagent is rocked vibrations, it is to avoid some precipitations caused in fine straining processing procedure simultaneously Filter is not exclusively;
S4: sterilization treatment, uses the mode of high-temp steam sterilizing, is put into by mix reagent in high-temperature steam cabinet and carry out at sterilizing Reason, sterilization time is at least 30 minutes;
S5: Detection, detects the mix reagent via high-temp steam sterilizing, examines after taking out reagent on detection equipment Survey, thus learn whether sterilizing reaches standard;
S6: sub-bottle packaging, is vacuum-packed in the vial by detecting qualified mix reagent through S5.
A kind of eye drip Rimactane that the present invention provides and preparation method thereof, makes eye by the mixing of Multiple components Liquid medicine can obtain the effect of good fatigue alleviating, has higher bactericidal antiphlogistic effect simultaneously, can be effectively by infection Pathogenic bacteria eliminates, and is effectively eliminated by ocular disease.
The above, the only present invention preferably detailed description of the invention, but protection scope of the present invention is not limited thereto, Any those familiar with the art in the technical scope that the invention discloses, according to technical scheme and Inventive concept equivalent or change in addition, all should contain within protection scope of the present invention.

Claims (4)

1. an eye drip Rimactane, it is characterised in that: its raw material is as follows: rifampicin 8-10 gram, sodium chloride 0.3-0.5 gram, Borneolum Syntheticum 2-3 gram, sodium dihydrogen phosphate 1-1.5 gram, disodium hydrogen phosphate 1-1.3 gram, boric acid 0.5-0.8 gram, ethylenediamine Tetraacethyl disodium 0.6-0.8 gram, taurine 0.1-0.2 gram, water for injection 80-100 milliliter.
A kind of eye drip Rimactane the most according to claim 1, it is characterised in that: described Borneolum Syntheticum is after grinding Powder, and powder mesh number is 800 mesh.
A kind of eye drip Rimactane the most according to claim 1, it is characterised in that: described disodium hydrogen phosphate and phosphoric acid Sodium dihydrogen is anhydrous state.
4. the preparation method of the eye drip Rimactane described in a claim 1, it is characterised in that: comprise the steps:
The preparation of S1: reagent bottle, carries out sterilization treatment by reagent bottle at high-temperature steam cabinet, and being then dried process can make With;
S2: by rifampicin, sodium chloride, Borneolum Syntheticum, sodium dihydrogen phosphate, disodium hydrogen phosphate, boric acid, disodiumedetate, cattle sulphur Acid and water for injection join and carry out in reagent bottle dissolving mixing, it is thus achieved that mix reagent, use water-bath during dissolving mixing The mode of heating, bath temperature controls between 50-60 degree Celsius;
S3: fine straining processes, and the mix reagent obtained in S2 is carried out in defecator filtration treatment, and the mesh number of drainage screen is 800 mesh, need mix reagent is rocked vibrations, it is to avoid some precipitations caused in fine straining processing procedure simultaneously Filter is not exclusively;
S4: sterilization treatment, uses the mode of high-temp steam sterilizing, is put into by mix reagent in high-temperature steam cabinet and carry out at sterilizing Reason, sterilization time is at least 30 minutes;
S5: Detection, detects the mix reagent via high-temp steam sterilizing, examines after taking out reagent on detection equipment Survey, thus learn whether sterilizing reaches standard;
S6: sub-bottle packaging, is vacuum-packed in the vial by detecting qualified mix reagent through S5.
CN201610744871.3A 2016-08-29 2016-08-29 A kind of eye drip Rimactane and preparation method thereof Pending CN106176593A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108690313A (en) * 2017-04-07 2018-10-23 健管(厦门)环境科技有限公司 A kind of tube inner linking material for pipeline local repair and its manufacturing method and application

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1185953A (en) * 1996-12-27 1998-07-01 刘伟中 Eye drop containing rich oxygen and preparation thereof
CN1629679A (en) * 2003-12-16 2005-06-22 上海卫康光学有限公司 Ophthalmic solution containing borneol and usage thereof
CN103394077A (en) * 2010-06-25 2013-11-20 杨红宇 Eye drop
WO2016014437A1 (en) * 2014-07-21 2016-01-28 Hiroaki Serizawa Ophthalmic compositions of rifamycins and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1185953A (en) * 1996-12-27 1998-07-01 刘伟中 Eye drop containing rich oxygen and preparation thereof
CN1629679A (en) * 2003-12-16 2005-06-22 上海卫康光学有限公司 Ophthalmic solution containing borneol and usage thereof
CN103394077A (en) * 2010-06-25 2013-11-20 杨红宇 Eye drop
WO2016014437A1 (en) * 2014-07-21 2016-01-28 Hiroaki Serizawa Ophthalmic compositions of rifamycins and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108690313A (en) * 2017-04-07 2018-10-23 健管(厦门)环境科技有限公司 A kind of tube inner linking material for pipeline local repair and its manufacturing method and application

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Application publication date: 20161207