CN106176583A - A kind of salicylic acid gel and preparation method thereof - Google Patents
A kind of salicylic acid gel and preparation method thereof Download PDFInfo
- Publication number
- CN106176583A CN106176583A CN201610855100.1A CN201610855100A CN106176583A CN 106176583 A CN106176583 A CN 106176583A CN 201610855100 A CN201610855100 A CN 201610855100A CN 106176583 A CN106176583 A CN 106176583A
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- Prior art keywords
- salicylic acid
- gel
- dissolving
- acid gel
- polyethylene glycol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of salicylic acid gel, its component and percentage by weight thereof are as follows: salicylic acid 1 50；Polyethylene Glycol 30 60；Polyvinylpyrrolidone 20 50.The preparation method of the salicylic acid gel that the present invention provides is: mixed, in 40 60 DEG C of heating for dissolving with polyvinylpyrrolidone stirring by Polyethylene Glycol；Add salicylic acid, stirring and dissolving, obtain described salicylic acid gel.This salicylic acid gel is light yellow clear gel, and salicylic acid content can as little as 1%, it is also possible to up to 50%.The present invention can be intended to according to application, prepares the gel that salicylic acid content height is different, is respectively used to anti-acne, cutin dissolving, and treatment tinea unguium and goes the purposes such as wart.
Description
Technical field
The present invention relates to a kind of salicylic acid gel, the invention still further relates to the preparation method of this salicylic acid gel in addition.
Background technology
Salicylic acid, has another name called oxybenzoic acid, is a kind of fat-soluble organic acid, is slightly soluble in water, at ethanol, ether, chlorine
In Fang readily soluble.
Salicylic acid is a kind of conventional Cidex-7, and eczema, chronic eczema, comedo, dandruff all may use bigcatkin willow
Acid.Determination of Salicylic Acid is different, and pharmacological action is different, 1～3% concentration there is anti-acne and itching-relieving action, 5～10% concentration have
Cutin dissolve and anti-superficial mycosis effect, 15～20% concentration have treatment tinea unguium effect, 25% concentrations above have corrosion make
With, the salicylic acid of 40% high concentration has strong cutin corrosion property, is suitable to treat clavus, thick cocoon, viral verruca.
Chinese patent CN101664379A discloses a kind of salicylic acid gelling agent in 2010-03-10, and it is by following quality
The component composition of percentage ratio: salicylic acid 1～10%, substrate accounts for 0.5～20%, and stabilizer 0.01～0.02%, remaining is solvent.
The invention also discloses the preparation method of above-mentioned salicylic acid gelling agent.In Chinese patent CN101664379A, salicylic acid gel uses
Macromolecule gel forming materials.
Chinese patent CN105517535A discloses the water being made up of salicylic acid and stabilizer compounds in 2016-04-20
Poplar acid gel, salicylic acid accounts for the gel gross weight of at least 1 weight %.Comprise the bigcatkin willow acid cure of salicylic acid and stabilizer compounds
Glue, wherein salicylic acid accounts for the gel gross weight of at least 30 weight %.Described gel can dilute and/or mix final skin protection
Product.
Salicylic acid is slightly soluble in water, it is difficult to make clear and bright aqueous solution.Salicylic acid is unstable in emulsifiable paste system, the highest
Concentration salicylic acid has direct destruction to emulsifiable paste system, so being typically only capable to make ointment formulation.Salicylic acid is equally to card ripple
The thickened systems such as nurse, cellulose has direct destruction, it is impossible to form stable gel rubber system.
Summary of the invention
For the above-mentioned deficiency of Salicylic Acid Formulations in prior art, according to embodiments of the invention, it is desirable to provide Yi Zhongxing
The salicylic acid gel that matter stable uniform, salicylic acid content height is controlled, and the preparation method of this salicylic acid gel is proposed.
According to embodiment, a kind of salicylic acid gel that the present invention provides, its component and percentage by weight thereof are as follows:
Salicylic acid 1-50；
Polyethylene Glycol 30-60；
Polyvinylpyrrolidone 20-50.
Preferably, the average average molecular weight of described Polyethylene Glycol is 200-600, described polyvinylpyrrolidone average
Number-average molecular weight is 5000-50000, and Polyethylene Glycol is 1:0.5-1:1 with the ratio of polyvinylpyrrolidone.
According to embodiment, the preparation method of a kind of salicylic acid gel that the present invention provides, by Polyethylene Glycol and polyethylene pyrrole
Pyrrolidone stirring mixing, in 40-60 DEG C of heating for dissolving；Add salicylic acid, stirring and dissolving, obtain described salicylic acid gel.
The present invention uses Polyethylene Glycol to be carrier with the common molten thing of polyvinylpyrrolidone, creates salicylic acid and expects not
The solvability arrived, and the light yellow clear gel of forming properties stable uniform.
The present invention uses low molecular poly to be solvent.When low molecular poly closes with polyvinylpyrrolidone
Used time, create beyond thought effect.Polyethylene Glycol is formed the most molten with polyvinylpyrrolidone 40-60 DEG C of heating for dissolving
Thing, salicylic acid concentration of ordinary dissolution in this altogether molten thing can reach more than 50%, and forming properties stable uniform is light yellow
Clear gel.
Embodiment subsequently will demonstrate that, salicylic acid gel of the present invention, and salicylic acid content can as little as 1%, it is also possible to up to
50%.The present invention can be intended to according to application, prepares the gel that salicylic acid content height is different, is respectively used to anti-acne, cutin
Dissolve, and treat tinea unguium and go the purposes such as wart.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is expanded on further.These embodiments are interpreted as being merely to illustrate this
Bright rather than limit the scope of the invention.After having read the content that the present invention records, those skilled in the art can
To make various changes or modifications the present invention, these equivalences change and modifications and fall into the model that the claims in the present invention are limited equally
Enclose.
Embodiment 1
By polyethylene glycol 200 (average average molecular weight is 200) 500 grams, (average is equal with polyvinylpyrrolidone K-25
Molecular weight is 32000) 490 grams of stirring mixing, in 40 DEG C of heating for dissolving；Add salicylic acid 10 grams, stirring and dissolving, obtain described water
Poplar acid gel.
This gel is light yellow clear gel, and after testing, in gel, salicylic acid content is 1%.
Embodiment 2
By PEG400 (average average molecular weight is 400) 350 grams, (average is equal with PVP K-30
Molecular weight is 37900) 250 grams of stirring mixing, in 60 DEG C of heating for dissolving；Add salicylic acid 400 grams, stirring and dissolving, obtain described
Salicylic acid gel.
This gel is light yellow clear gel, and after testing, in gel, salicylic acid content is 40%.
Embodiment 3
By Macrogol 600 (average average molecular weight is 600) 600 grams, (average is equal with polyvinylpyrrolidone K-15
Molecular weight is 5500) 350 grams of stirring mixing, in 50 DEG C of heating for dissolving；Add salicylic acid 50 grams, stirring and dissolving, obtain described water
Poplar acid gel.
This gel is light yellow clear gel, and after testing, in gel, salicylic acid content is 5%.
Embodiment 4
By PEG400 (average average molecular weight is 400) 550 grams, (average is equal with polyvinylpyrrolidone K-17
Molecular weight is 10100) 300 grams of stirring mixing, in 50 DEG C of heating for dissolving；Add salicylic acid 150 grams, stirring and dissolving, obtain described
Salicylic acid gel.
This gel is light yellow clear gel, and after testing, in gel, salicylic acid content is 15%.
Embodiment 5
By PEG400 (mean molecule quantity is 400) 250 grams, (mean molecule quantity is with PVP K-30
37900) 250 grams of stirring mixing, in 60 DEG C of heating for dissolving；Add salicylic acid 500 grams, stirring and dissolving, obtain described bigcatkin willow acid cure
Glue.
This gel is light yellow clear gel, and in gel, salicylic acid content is 50%.
The salicylic acid gel taking the various embodiments described above prepared carries out stability test, and result is as follows:
Hot test: place 10 days, all without precipitation, separation, metachromatism for 60 DEG C.
Low temperature resistant test: place 10 days, all without precipitation, separation, metachromatism for-18 DEG C.
Freezing and thawing test :-18 DEG C/room temperature freeze thawing 3 circulation, all without precipitation, separation, metachromatism.
Accelerated stability test: place 6 months, all without precipitation, separation, metachromatism, salicylic acid content rate of descent for 40 DEG C
It is respectively less than 6% (the results are shown in Table 1).
Salicylic acid content change (%) in 1.40 DEG C of accelerated stability test gels of table
| Sample number | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| 0 day | 1.05 | 40.88 | 5.24 | 15.73 | 50.99 |
| 6 months | 1.01 | 39.04 | 5.08 | 14.92 | 48.40 |
| Content rate of descent | 3.81 | 4.50 | 3.05 | 5.15 | 5.08 |
In sum, salicylic acid gel preparation technology of the present invention is easy, can be intended to according to application, prepare salicylic acid content
The most different gels.The salicylic acid gel outward appearance that various embodiments of the present invention prepare is light yellow, as clear as crystal, stable in properties.
Claims (5)
1. a salicylic acid gel, it is characterised in that its component and percentage by weight thereof are as follows:
Salicylic acid 1-50；
Polyethylene Glycol 30-60；
Polyvinylpyrrolidone 20-50.
Salicylic acid gel the most according to claim 1, it is characterised in that the average average molecular weight of described Polyethylene Glycol is
200-600。
Salicylic acid gel the most according to claim 1, it is characterised in that the average of described polyvinylpyrrolidone is divided equally
Son amount is 5000-50000.
Salicylic acid gel the most according to claim 1, it is characterised in that Polyethylene Glycol and the weight of polyvinylpyrrolidone
Ratio is 1:0.5-1:1.
5. the preparation method of salicylic acid gel described in claim 1-4 any one, it is characterised in that by Polyethylene Glycol and poly-second
Alkene pyrrolidone stirring mixing, in 40-60 DEG C of heating for dissolving；Add salicylic acid, stirring and dissolving, obtain described salicylic acid gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610855100.1A CN106176583A (en) | 2016-09-27 | 2016-09-27 | A kind of salicylic acid gel and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610855100.1A CN106176583A (en) | 2016-09-27 | 2016-09-27 | A kind of salicylic acid gel and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106176583A true CN106176583A (en) | 2016-12-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610855100.1A Pending CN106176583A (en) | 2016-09-27 | 2016-09-27 | A kind of salicylic acid gel and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111995472A (en) * | 2020-09-15 | 2020-11-27 | 成都云图控股股份有限公司 | Disease-resistant growth-promoting type composite slow-release fertilizer and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101288643A (en) * | 2008-06-17 | 2008-10-22 | 杨喜鸿 | Gel composition containing tacrolimu and its preparation method and medicinal application |
| CN101664379A (en) * | 2009-09-22 | 2010-03-10 | 南京白敬宇制药有限责任公司 | Salicylic acid gelling agent and preparation method thereof |
| CN105517535A (en) * | 2013-03-08 | 2016-04-20 | 优势特色组分公司 | Salicylic acid gel |
-
2016
- 2016-09-27 CN CN201610855100.1A patent/CN106176583A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101288643A (en) * | 2008-06-17 | 2008-10-22 | 杨喜鸿 | Gel composition containing tacrolimu and its preparation method and medicinal application |
| CN101664379A (en) * | 2009-09-22 | 2010-03-10 | 南京白敬宇制药有限责任公司 | Salicylic acid gelling agent and preparation method thereof |
| CN105517535A (en) * | 2013-03-08 | 2016-04-20 | 优势特色组分公司 | Salicylic acid gel |
Non-Patent Citations (3)
| Title |
|---|
| MIKHAIL B. NOVIKOV ET AL.: ""Dynamic mechanical and tensile properties of poly(N-vinyl pyrrolidone)–poly(ethylene glycol) blends"", 《POLYMER》 * |
| 张扬等: ""水杨酸凝胶剂的研制"", 《吉林化工学院学报》 * |
| 高静等: "《物理化学》", 31 January 2016, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111995472A (en) * | 2020-09-15 | 2020-11-27 | 成都云图控股股份有限公司 | Disease-resistant growth-promoting type composite slow-release fertilizer and preparation method thereof |
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Application publication date: 20161207 |