CN106166262A - 一种治疗慢性肾衰竭的中药组合物 - Google Patents

一种治疗慢性肾衰竭的中药组合物 Download PDF

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CN106166262A
CN106166262A CN201610617818.7A CN201610617818A CN106166262A CN 106166262 A CN106166262 A CN 106166262A CN 201610617818 A CN201610617818 A CN 201610617818A CN 106166262 A CN106166262 A CN 106166262A
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邓炳章
朱珍菊
邓万睿
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Abstract

本发明公开一种治疗慢性肾衰竭的中药组合物,由下述重量份配比的原料制成:党参30‑45份、茯苓30‑60份、白术30‑120份、炙甘草30‑45份、生黄芪30‑60份、泽泻15‑60份、藿香10‑15份、酒大黄5‑20份、砂仁10‑15份、五味子10‑15份、制附片10‑30份、桂枝45‑75份、当归10‑30份、肉桂10‑15份、薏苡仁30‑60份,按制药领域的常规辅料和工艺制备成内服制剂。本发明有益效果是:本发明选用纯中药原料配制而成,配伍严谨,辩证立法,方药得当对症,能有效治疗氮质血症,可使血肌酐、尿素氮显著降低,明显减轻和延缓肾衰病情。

Description

一种治疗慢性肾衰竭的中药组合物
技术领域
本发明属于中药领域,涉及一种治疗慢性肾衰竭的中药组合物。
背景技术
慢性肾衰竭也叫慢性肾功能不全,是由多种原发或继发肾脏疾患导致肾实质慢性进行性损害,是肾脏的基本功能难以维持,如水盐代谢平衡失调、机体代谢废物不能正常排泄,各种激素的分泌和调节受损,引起氮质血症为主要矛盾的一系列临床综合征。临床表现恶心、呕吐、腹胀、乏力、饮食减少、尿少,严重者出现心衰、心律失常、高血压、贫血、出血、昏迷等症状导致死亡,其病理机制复杂。目前对此病西医药物较少,治疗措施主要以透析为主,费用较高。
发明内容
本发明的目的是提出一种治疗慢性肾衰竭的药物,从中医治疗上开辟一条路,降低病人的治疗痛苦,花费比透析低。
本发明采用的技术方案是:一种治疗慢性肾衰竭的中药组合物,由下述重量份配比的原料制成:党参30-45份、茯苓30-60份、白术30-120份、炙甘草30-45份、生黄芪30-60份、泽泻15-60份、藿香10-15份、酒大黄5-20份、砂仁10-15份、五味子10-15份、制附片10-30份、桂枝45-75份、当归10-30份、肉桂10-15份、薏苡仁30-60份,按制药领域的常规辅料和工艺制备成内服制剂。
进一步的,本发明优选重量份配比为:党参30份、茯苓60份、白术60份、炙甘草30份、生黄芪45份、泽泻45份、藿香15份、酒大黄10份、砂仁10份、五味子10份、制附片10份、桂枝45份、当归10份、肉桂10份、薏苡仁45份。
进一步的,其水剂的加工方法是称量、混合各药物后,每份组合物用6-9倍的清水浸泡1小时以上,煎熬3-4小时,过滤后饮服。
进一步的,其丸剂的加工方法是将中药组合物各组分分别粉碎后混合,过千目筛,细粉加熬制蜂蜜,制成药丸,每丸重6-9g。
本发明有益效果是:本发明选用纯中药原料配制而成,配伍严谨,辩证立法,方药得当对症,能有效治疗氮质血症,可使血肌酐、尿素氮显著降低,明显减轻和延缓肾衰病情。
本申请人认为慢性肾衰竭属于中医癃闭、关格、水肿等范畴,其主要病因是由外感内伤及他病转化,“穷必及肾”,致脾肾衰败,水谷精微不从正化,“水反为湿,谷反为滞”,脾不能运化水湿,肾不能化气行水,水湿内停,清者不能升而漏泄,浊者不能降而内聚,蕴积而成毒,湿毒内停,五脏失养而见多种症状,后天胃气乃先天生气之根,肝肾同源,三阴统于太阴,“土生万物,无土不生世界”,所以健运中气,是治疗关键,健运中气,条达肝气,肃降肺气,承降胃气,温心阳,中焦斡旋失职,无法灌溉,滋养四旁,肝失条达疏泄,肺失宣发肃降,肾失化气行水。
本发明本着健脾助运,斡旋中气,使水湿毒邪有路可排,五脏得以灌溉,肾之化气行水功能可复。方中党参、茯苓、白术、炙甘草健脾助运。大量白术健脾利湿,斡旋中气,生黄芪补气利水,内经云:“中气不足,溲便为之变”,转轴运轮,为君药;茯苓、泽泻淡渗利湿,砂仁、藿香芳香化湿,薏苡仁清热利湿,酒大黄泻阳明、胃经蕴久之湿毒,上药利湿解毒祛邪共为臣药;肉桂温补命门之火,化气行水,温通血脉,灵动下焦,桂枝温补心阳,虚则补其母,补火以生土,防阴寒之邪上乘,助膀胱化气行水,肝为罢极之本,还入厥阴肝经,助厥阴风木和缓有序生发,五味子性温,五味具备,酸咸为多,故专敛肺气而滋肾水,益气生津,当归活血补血,小剂量附子温补脾肾阳气,通行十二经,增加釜底之火,温脾助运,为佐使之药。全方健运中焦,斡旋中气,祛邪与扶正并用,通过祛邪恢复土生万物,脾为后天之本功能,益后天以养先天,恢复肾之主水功能。
具体实施方式
实施例1
一种治疗慢性肾衰竭的中药组合物,由下述重量份配比的原料制成:党参30份、茯苓60份、白术60份、炙甘草30份、生黄芪45份、泽泻45份、藿香15份、酒大黄10份、砂仁10份、五味子10份、制附片10份、桂枝 45份、当归10份、肉桂10份、薏苡仁45份,按制药领域的常规辅料和工艺制备成内服制剂。
实施例2
重量份配比:党参45份、茯苓60份、白术120份、炙甘草45份、生黄芪30份、泽泻50份、藿香10份、酒大黄20份、砂仁15份、五味子15份、制附片30份、桂枝75份、当归30份、肉桂15份、薏苡仁60份,按制药领域的常规辅料和工艺制备成内服制剂。
实施例3
重量份配比:党参30份、茯苓60份、白术100份、炙甘草30份、生黄芪45份、泽泻45份、藿香15份、酒大黄15份、砂仁10份、五味子10份、制附片10份、桂枝45份、当归10份、肉桂10份、薏苡仁45份,按制药领域的常规辅料和工艺制备成内服制剂。
实施例4
重量份配比:党参30份、茯苓60份、白术100份、炙甘草30份、生黄芪60份、泽泻60份、藿香10份、酒大黄20份、砂仁10份、五味子10份、制附片10份、桂枝75份、当归12份、肉桂10份、薏苡仁60份,按制药领域的常规辅料和工艺制备成内服制剂。
实施例5
重量份配比:党参30份、茯苓30份、白术60份、炙甘草30份、生黄芪45份、泽泻30份、藿香10份、酒大黄10份、砂仁10份、五味子10份、制附片10份、桂枝45份、当归10份、肉桂10份、薏苡仁30份,按制药领域的常规辅料和工艺制备成内服制剂。
治疗水剂的方法是加入上述中药6-9倍的清水浸泡1小时,煎熬3小时,晾凉后过滤用塑料袋密封、灭菌、包装,每剂3袋,每袋100ml,饭前空腹服,每日3次,每4小时一次。如作丸散剂型可将中药组合物分别粉碎后混合用千目筛筛过后,用蜂蜜和成蜜丸,每丸重6-9g。如果做胶囊剂型可以装入大号胶囊(每粒重1.0g)。服用期间:连服一月为一周期,三月为一疗程。服药禁忌:忌食生冷、植物蛋白、损肾药物、豆腐、啤酒。
临床实验
一、中医辩证标准
符合诊断脾肾阳衰、湿浊停滞,脾不能运化水湿,肾不能化气行水致慢性肾衰竭的患者。临床症见恶心、呕吐、食欲较差、小便减少、疲乏无力、浮肿等症状,病人体型黄胖,面色晄白或黧黑,白天小便较少,夜间小便较多,逐渐出现劳力性呼吸困难,动则气短汗出,部分患者口中有尿味,舌质淡,苔白腻,舌体胖大满口,边有齿印,双手寸关脉沉细而数。
二、治疗方法
1.选取50例,采取随机分组自身对照比较法,比较患者治疗前后的症状、体征和结果的变化。
2.立法:健脾运中、健脾燥湿、淡渗利湿、芳香化湿、清热利湿、益气利水、温阳利湿,疏泄肝气、肃降肺气、清泻阳明、温补心阳及命门之火,通过健运中焦、斡旋中气,恢复土气,最终达到恢复脾能运化水湿,肾能化气行水之目的。
3.服药方法:服用本发明中剂量药物,每日三次,每次服大号胶囊10-15粒(每粒为1.0g),连服一月为一周期,六月为一疗程。主症状没有其它兼症,服用小剂量药物;主症重病发症多,服用大剂量药物。
三、疗效观察指标:经3-5个疗程治疗,临床症状消失或改善,血肌酐、尿素氮在正常范围或接近正常范围。
四、疗效判断标准
1.治愈:临床症状改善,血肌酐、尿素氮在正常范围或接近正常范围,停药一年再无反复;
2.显效:服药控制,血肌酐、尿素氮接近正常范围,一年以上没有复发;
3.有效:症状减轻,血肌酐、尿素氮指数下降。
4.无效:症状无明显改变,血肌酐、尿素氮指数无改善。
五、治疗效果
本药物在临床应用中未见明显的毒副作用,上五十例患者服用未发现不良反应。用以上方案治疗三个疗程,治疗50例,治愈率70%,有效率100%。总体疗效见下表一。
表一 五十例患者疗效统计表
典型病例
病例一:刘某,男,53岁,农民,2009年7月24日初诊,病人自述:患糖尿病21年,晨起恶心、呕吐、食欲较差、小便白天减少、夜间较多,疲乏无力、浮肿等症状1年,坚持胰岛素、降压等药物治疗,血糖血压控制一般,来我院住院治疗,查血肌酐326mmol/l,尿素氮16mmol/l。
观察病人:颜面晄白,眼睑轻度水肿,双下肢中度凹陷性水肿,舌体胖大,边有齿印,舌质淡,苔白,动则气短汗出,脉诊:双手寸关脉沉细而数。
诊断:脾肾衰败,水饮、湿浊停滞,五脏失养。立法:健脾运中、健脾燥湿、淡渗利湿、芳香化湿、清热利湿、益气利水、温阳利湿,疏泄肝气、肃降肺气、清泻阳明、温补心阳及命门之火。服药方法:本组方中药6-9倍的清水浸泡1小时,煎熬3小时,晾凉后过滤用塑料袋密封、灭菌、包装,每剂3袋,每袋100ml,饭前空腹服,每日3次,每4小时一次。继续原治疗方案,加用上述中药加减治疗1年,血肌酐:101mmol/l,尿素氮9.8mmol/l,以上症状明显减轻,继续进行中药治疗1年,上述指标恢复正常,给与散剂巩固治疗。
病例二:患者刘某,男,67岁,2006年3月16日就诊,因疲乏无力,恶心呕吐,小便减少般下肢浮肿入院。近1周恶心呕吐多,晨起明显,大便秘结,查血压140/90mmhg,血Cr389mmol/L,BUN12.6mmol/L。
病人体征:面色晄白,食欲差,大便干,3日1行,舌质红,苔白腻,脉象弦滑,右迟重按无力。
诊断:脾肾衰败,水饮、湿浊停滞化热。立法:健脾运中、健脾燥湿、淡渗利湿、芳香化湿、清热利湿、益气利水、温阳利湿,疏泄肝气、肃降肺气、温补心阳及命门之火,重用清泻阳明。服药方法:本组方中药6-9倍的清水浸泡1小时,煎熬3小时,晾凉后过滤用塑料袋密封、灭菌、包装,每剂3袋,每袋100ml,饭前空腹服,每日3次,每4小时一次。继续原治疗方案,加用上述中药加减治疗1年,血肌酐:196mmol/l,尿素氮11.8mmol/l,以上症状明显减轻,继续进行中药治疗1年,上述指标恢复正常,给与散剂巩固治疗,血肌酐、尿素氮指标基本稳定。
病例三:马某,男,72岁,2008年11月16日初诊,患慢性肾炎8年。
病人自述:体检时发现尿常规+++,血浆蛋白正常,血肌酐:160mmol/l,尿素氮8.2mmol/l,自感乏力,腹胀,余无特殊不足,血压正常。
诊断:舌淡,苔薄白,脉诊双手脉(肝、脾、肾三脏之脉)沉迟而紧。立法::健脾运中、健脾燥湿、淡渗利湿、芳香化湿、清热利湿、益气利水、温阳利湿,疏泄肝气、肃降肺气、温补心阳及命门之火,服药方法:将本组方做成胶囊剂型,装入大号胶囊(每粒重1.0g),每次6粒,每日3次,服用期间:连服一月为一周期,三月为一疗程。共药1年,血肌酐、尿素氮指标正常,自觉症状消失。

Claims (4)

1.一种治疗慢性肾衰竭的中药组合物,其特征是由下述重量份配比的原料制成:党参30-45份、茯苓30-60份、白术30-120份、炙甘草30-45份、生黄芪30-60份、泽泻15-60份、藿香10-15份、酒大黄5-20份、砂仁10-15份、五味子10-15份、制附片10-30份、桂枝45-75份、当归10-30份、肉桂10-15份、薏苡仁30-60份,按制药领域的常规辅料和工艺制备成内服制剂。
2.根据权利要求1所述的一种治疗慢性肾衰竭的中药组合物,其特征是由下述重量份配比的原料制成:党参30份、茯苓60份、白术60份、炙甘草30份、生黄芪45份、泽泻45份、藿香15份、酒大黄10份、砂仁10份、五味子10份、制附片10份、桂枝45份、当归10份、肉桂10份、薏苡仁45份。
3.根据权利要求1所述的一种治疗慢性肾衰竭的中药组合物,其水剂的加工方法是称量、混合各药物后,每份组合物用6-9倍的清水浸泡1小时以上,煎熬3-4小时,过滤后饮服。
4.根据权利要求1所述的一种治疗慢性肾衰竭的中药组合物,其丸剂的加工方法是将中药组合物各组分分别粉碎后混合,过千目筛,细粉加熬制蜂蜜,制成药丸,每丸重6-9g。
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CN107029191A (zh) * 2017-03-07 2017-08-11 沈阳耀灸生物科技有限公司 用于改善肾功能的药香及其制备方法
CN107029191B (zh) * 2017-03-07 2021-04-06 大连耀灸生物科技有限公司 用于改善肾功能的药香及其制备方法
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