CN106166208A - A kind of Chinese medicine composition for treating ulcerative colitis - Google Patents

Abstract

The present invention relates to technical field of traditional Chinese medicine, be specifically related to a kind of Chinese medicine composition for treating ulcerative colitis.Chinese medicine composition includes following raw material by weight: Radix Codonopsis 25 35g, the Radix Astragali 25 35g, Radix Sophorae Flavescentis 4 7g, the Rhizoma Atractylodis Macrocephalae 13 17g, Rhizoma Dioscoreae 40 50g, Poria 8 12g, Radix Angelicae Sinensis 8 12g, Radix Paeoniae Rubra 10 14g, Radix Notoginseng 1 5g, stir-baked RHIZOMA CORYDALIS with vinegar 7 12g, Oletum Trogopterori 4 8g, Radix Salviae Miltiorrhizae 10 14g, Fructus Crataegi (parched to brown) 10 15g, Olibanum 8 12g, Myrrha 8 12g, the Radix Linderae 8 13g, Radix Glycyrrhizae Preparata 4 8g.The Chinese medicine composition that the present invention provides, total effective rate is 95%, the primary symptoms such as diarrhoea, mucopurulent bloody stool, tenesmus all there are is improvement result, the pathological changes such as stool routine examination, CRP, mucosal inflammation, ulcer, crypt abscess, goblet cell minimizing are also had improvement result.

Description

A kind of Chinese medicine composition for treating ulcerative colitis

Technical field

The present invention relates to technical field of traditional Chinese medicine, be specifically related to a kind of Chinese drug-treated group for treating ulcerative colitis Compound.

Background technology

Ulcerative colitis (ulcerative colitis, UC), a kind of agnogenic spy sends out in rectum and colon Inflammatory bowel, also known as chronic nonspecific ulcerative colitis, pathological changes mainly invades mucous layer and tela submucosa, is commonly formed gruel Rotten, ulcer.Be equivalent to " having loose bowels ", " dysentery ", " having blood in stool " of Chinese medicine, " stomachache " etc., Chinese medicine belongs to " intestinal ", " dysentery " Deng category.

Primary disease is common with country of Europe, the United States, just has relevant record as far back as B.C..But until 1875, primary disease was proved also Caused by non-dysentery pathogenic strain, just recognized by people as a kind of independent disease, the sickness rate that discovered in recent years is domestic In rising trend.Any age all can fall ill, but is more common in the adult of 20～40 years old, and men and women's sickness rate is without significant difference.Clinical With the bowel symptoms such as diarrhoea, mucus bloody purulent stool, stomachache as main clinical manifestation, double see various General Symptoms.Primary disease state of an illness weight Great disparity, recurrent exerbation, the course of disease is longer, and has the tendency that cancerates when pathological changes relates to whole large intestine.Investigate according to western countries, exedens It is high that colitis sickness rate has sickness rate in obvious racial diversity, Caucasian and Jew；In terms of area, North America and north The annual morbidity in Europe is high, about 3-15/10 ten thousand populations, but the differing greatly of each department, area, Asia and Africa is the Di Fa district of primary disease.I State's number of the infected is few more than American-European number of the infected, but ulcerative colitis presents, at the sickness rate of China, becoming of being gradually increased Gesture.According to the domestic literature of the 1989-2003 that Hu Renwei etc. adds up, in 15 years, report inflammatory bowel 143511 example altogether, its Middle ulcerative colitis accounts for 140114 examples.

Modern medicine is the most immature to the research of Ulcerative Colitis at present.Ulcerative colitis pathogenesis is multiple Miscellaneous, the cause of disease is still not clear, may be relevant to factors such as environment, microorganism, heredity, immunity, psychiatric.The most more generally acknowledge About the view of Ulcerative Colitis, being still based on the hypothesis of Kirsner and Shorter, this hypothesis is thought in early days Antigen enters, and makes gut associated lymphoid tissues be upset, and body becomes sensitive to it, it is established that a kind of to normal Enterobacter cloaca antigen Or the hypersensitive state of intracavity antigen and mucosa-immune imbalance.This hypersensitive state is mainly enteropathy persistent levels, the most any destruction The secondary factor of gut barrier, will make antigen contact once again with these lymphoid tissues, and excite local immunity to react, and cause local Inflammation.In recent years, immunologic research be concentrated mainly on immunological lymphocyte (Thl/Th2), Th17/Treg cell, cell because of Son (Cytokines, CK), nuclear transcription factor-kappa B (NF-κ B), Toll-like receptor 4 (toll-like receptor 4, TLR- 4), peroxisome proliferator-activated receptors-γ (PPAR-γ), adhesion molecule-l (ICAM-l), jaw sample transcription factor- P3 (Foxp3), signal transduction and activating transcription factor-4 (STAT-4), apoptosis (Apoptosis), nitric oxide (NO), Oxygen-derived free radicals (OFR), P select several aspects such as element (PS).

Chinese medicine is thought, primary disease belongs to " chronic diarrhea ", " chronic dysentery with frequent relapse " category.Its sick position mainly at taste, relate to Liver and kidney, the course of disease one As longer, characteristic of disease mostly is deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive, cold and heat and deposits.The initial onset phase is the most real, and how empty the prolonged illness catabasis is.Ulcer If property colitis is treated not in time, digestive tract hemorrhage, toxic megacolon, intestinal perforation, polyp, intestinal stenosis, rectum often occur With complication such as crissum pathological changes, it is slow that some patients there is also hepatic lesions, arthritis, skin, oculopathy, thromboembolism, growth The parenteral performances such as stagnant, enteritis, have a strong impact on quality of life and the life span of patient.Patients of ulcerative colitis is than general There is probability height 5-20 times of colon cancer, the course of disease patient canceration rate average annual growth 1%-2% of more than 10 years in crowd.Due to ulcer Property colitis has the features such as acute fulminant form's case fatality rate height, high, the easy recurrent exerbation of chronic sustained type canceration rate, is defined For disease before cancer, it is classified as one of modern difficult treatment by World Health Organization (WHO).

Ulcerative colitis presents, at the sickness rate of China, the trend of being gradually increased.If treatment is not in time, digestion often occurs The complication such as gastrointestinal hemorrhage, toxic megacolon, intestinal perforation, polyp, intestinal stenosis, rectum and crissum pathological changes, some patients also can go out The parenteral performances such as existing hepatic lesions, arthritis, skin, oculopathy, thromboembolism, growthing lag, enteritis, have a strong impact on patient's Quality of life and life span.The most immature to the research of Ulcerative Colitis.But ulcer Property colitis pathogenesis complicated, the cause of disease is still not clear, may be relevant to the factor such as environment, microorganism, heredity, immunity, psychiatric. And current western medicine medicine such as mesalazine, hormone etc., there is bigger side effect.Patient uses these medicines to one The fixed time, more likely produce drug resistance.Therefore, develop a kind of Chinese medicine effective, that side effect is little to become and need solution at present badly Problem certainly.

Summary of the invention

It is an object of the invention to provide a kind of Chinese medicine composition for treating ulcerative colitis, this Chinese medicine composition is total Effective percentage is 95%, and its curative effect is better than GUCHANG ZHIXIE WAN, all has improvement to make to primary symptoms such as diarrhoea, mucopurulent bloody stool, tenesmus With, diarrhoea, mucopurulent bloody stool improvement result are better than GUCHANG ZHIXIE WAN, stool routine examination, CRP are all had improvement result, to mucosa The pathological changes such as inflammation, ulcer, crypt abscess, goblet cell minimizing also have improvement result.

In order to realize object above, the present invention adopts the following technical scheme that

A kind of Chinese medicine composition for treating ulcerative colitis, includes following raw material by weight: Radix Codonopsis 25- 35g, Radix Astragali 25-35g, Radix Sophorae Flavescentis 4-7g, Rhizoma Atractylodis Macrocephalae 13-17g, Rhizoma Dioscoreae 40-50g, Poria 8-12g, Radix Angelicae Sinensis 8-12g, Radix Paeoniae Rubra 10- 14g, Radix Notoginseng 1-5g, stir-baked RHIZOMA CORYDALIS with vinegar 7-12g, Oletum Trogopterori 4-8g, Radix Salviae Miltiorrhizae 10-14g, Fructus Crataegi (parched to brown) 10-15g, Olibanum 8-12g, Myrrha 8- 12g, Radix Linderae 8-13g, Radix Glycyrrhizae Preparata 4-8g.

Optionally, mark also includes Ramulus Cinnamomi 8-13g by weight.

Optionally, Radix Codonopsis 30g, Radix Astragali 30g, Radix Sophorae Flavescentis 6g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 45g, Poria 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 12g, Radix Notoginseng 3g, stir-baked RHIZOMA CORYDALIS with vinegar 10g, Oletum Trogopterori 6g, Radix Salviae Miltiorrhizae 12g, Fructus Crataegi (parched to brown) 12g, Olibanum 10g, Myrrha 10g, Radix Linderae 10g, process sweet Grass 6g.

Optionally, Radix Codonopsis 30g, Radix Astragali 30g, Radix Sophorae Flavescentis 6g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 45g, Poria 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 12g, Radix Notoginseng 3g, stir-baked RHIZOMA CORYDALIS with vinegar 10g, Oletum Trogopterori 6g, Radix Salviae Miltiorrhizae 12g, Fructus Crataegi (parched to brown) 12g, Olibanum 10g, Myrrha 10g, Radix Linderae 10g, process sweet Grass 6g, Ramulus Cinnamomi 10g.

Optionally, the dosage form of described Chinese medicine composition is granule or decoction.

Optionally, the preparation method of described decoction is fried the forming that added water by above-mentioned each raw material components, described fried for adopting Use 800-1000ml water, after mixing with Chinese medicine composition, fried 2-4h, obtain 570-630ml decoction.

Optionally, the using method of described decoction is: gained decoction is divided into 3 parts, and wherein two parts are respectively morning, mouth in evening Clothes, another portion of coloclysis.Described morning is oral, evening oral, coloclysis institute dosage is respectively as follows: 240-260 part, 240-260 part, 90-110 part.

Raw material is introduced:

Radix Codonopsis: property is put down, sweet in the mouth, micro-acid.Return spleen, lung meridian.For the key medicine of air making-up and spleen enlivening, can QI invigorating, can enrich blood again, often with The Rhizoma Atractylodis Macrocephalae of air making-up and spleen enlivening dehumidifying, Poria equivalent are used.Contained by it, human body multi viscera is had by saponin, inulin, Alkaloid, starch etc. Strong effect in various degree, can improve the adaptability of human body.There is antiulcer, intestinal tension force, regulation stomach motion can be increased, in conditioning The intestines and stomach preparation is reused the intestines and stomach regulation of mental activities agent of Radix Codonopsis to chronic diarrhea, ulcerative colitis, antral gastritis, chronic atrophic gastritis etc. Quite there is effect." book on Chinese herbal medicine must be joined ": " upper Radix Codonopsis, obtains Radix Astragali and defend in fact, join Semen Nelumbinis dysentery relieving, and monarch's Radix Angelicae Sinensis is invigorated blood circulation, and helps Semen Ziziphi Spinosae reinforcing the heart.Tonifying the lung Honey is mixed and is cooked；Its stagnation of QI is feared in spleen reinforcing, adds Cortex Mori number and divides, or adds Pericarpium Citri Reticulatae and also may be used.Control asthenia internal injury, intestinal cold in the stomach, slide and rush down chronic dysentery.”

The Radix Astragali: property is sweet, tepor.Return lung, spleen, liver, kidney channel.Shennong's Herbal is classified as top grade.Bright Compendium of Material Medica carries " over sixty years of age Grow also, Radix Astragali yellow skin, the length for benefit person is therefore named ... "." Radix Astragali, tonifying the lung spleen invigorating, defend real arresting sweating to " book on Chinese herbal medicine converges and says " load, and wind dispelling is transported The medicine of poison is also ... ".There are benefiting QI for strengthening the superficies, arresting sweating admittedly to take off, hold in the palm skin ulcer granulation promoting, effect of inducing diuresis to remove edema.Weak for treating the deficiency of vital energy, in Gas sink, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, and carbuncle difficulty is burst, and bursts for a long time and does not holds back, blood deficiency and yellow complexion, and interior-heat is quenched one's thirst, chronic renal Inflammation, albuminuria, diabetes etc..Especially it is suitable for the enteritis that bloody purulent stool is cardinal symptom to have loose bowels.

Radix Sophorae Flavescentis, for the dry root of leguminous plant Radix Sophorae Flavescentis, excavates in spring, season in autumn two, removing root head and little supporting root, cleaning, drying, Or take advantage of fresh slices, it is dried.It is bitter, cold.There are heat clearing and damp drying, parasite killing, the merit of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, red in vain Leukorrhagia, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, temperature.Return spleen, stomach warp.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For Insufficiency of the spleen lack of appetite, abdominal distention has loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." medicine origin " is recorded: " dehumidifying benefit is dry, and middle benefit Gas, warming middle-JIAO, go in taste wet, except gastric heat, strong taste, enter diet, quench the thirst, antiabortive." modern pharmacology research confirmation, Rhizoma Atractylodis Macrocephalae water Decocting liquid has the effect significantly adjusting gastrointestinal motility function.With intestinal tube residing for functional status relevant.Have emerging under normal circumstances The effect of putting forth energy, when intestinal tube is in excitatory state by acetylcholine effect, the Rhizoma Atractylodis Macrocephalae is inhibitory action；When intestinal tube is made by epinephrine With and when being in inhibitory state, the Rhizoma Atractylodis Macrocephalae, again in excitation, all can make intestinal tube activity recover to close to normal level.

Rhizoma Dioscoreae: sweet in the mouth, property is put down.Return spleen, lung, kidney channel.Having spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the merit of the kidney invigorating arresting seminal emission.For treating The diseases such as insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung are breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat are quenched one's thirst.Research shows, Rhizoma Dioscoreae can increase Strong Small Intestinal, suppression gastric emptying motion and Intestinal pushing effect, slow down intestinal peristalsis promoting, alleviates intestinal tube smooth muscle spasm, from And regulate gastrointestinal peristalsis frequency, improve symptom of diarrhea.

Poria: sweet in the mouth, light, flat, enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.With The Chinese medicine of other direct diuretic is different, and the diuretic of Poria is reached by strong activating the spleen pulmonary function.For diarrhea due to hypofunction of the spleen, band Lower Poria can spleen invigorating, again can eliminating dampness by diuresis, for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, Often and the compatibility such as Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy." detailed outline ": " Poria, " herbal " again Speech diuresis, cuts down kidney evil, is that the speech many persons of urine can stop to Dong Yuan, Wang Haizang, and puckery person can be led to, can secret true strength with Cinnabaris.And Zhu Dan Small stream says that again deficiency of YIN person should not use, and justice patibhaga-nimitta is anti-, what？Poria abnormal smells from the patient is light and oozes, and its property is up, born fluid, opens amine reason, grows water source And decline, diuresis, therefore Zhang Jiegu calls its genus sun, floats and rises, and says its property also；Dong Yuan call its for the YIN aspect of YANG, fall and under, Yan Qi Merit is also." " Plain Questions " cloud, " diet enters stomach, transporting essential substances in solution, upper defeated in lung, regulating fluid apssage, under defeated bladder.See this, then know and light ooze it Medicine, the most up then declines, non-straight descending also.Urine is many, and its source is the most different." we with this, also deposit treating diarrhea by diuretics it Meaning.

Chinese angelica blood supplementing is invigorated blood circulation, and essentials of Matea Medica has speech to say: " blood deficiency can be mended, and blood depletion can be moistened ", to insufficiency of generating and transforming QI and blood, or gas Blood operation is slow and blood deficiency dryness of the intestine constipation person is good medicine." Radix Paeoniae Rubra bitter in the mouth, cold nature.Return Liver Channel.There is clearing away heat and cooling blood, dissipate The function of stasis of blood pain relieving.Cure mainly: stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool.Radix Salviae Miltiorrhizae, " its bitter in the mouth is slightly cold " herbal classic " cloud；Tao Yun Property heat nontoxic, see its main trusted subordinate's pathogen, borborygmus are faint such as leakes water, and cold and heat gather, and broken disease is except abdominal mass.”

Radix Paeoniae Rubra, for ranunculaceae plant Radix Paeoniae Rubra or the dry root of river Radix Paeoniae Rubra.Spring, season in autumn two excavate, and remove rhizome, fibrous root and mud Sand, dries.Hardship, is slightly cold.Return Liver Channel.There is clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling, it is mainly used in treating thermal man's nutrient blood, temperature poison is sent out Speckle, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, addiction abdominal mass stomachache, injury from falling down, carbuncle skin infection.

Radix Notoginseng, for panax araliaceae plant dry root and rhizome.Nature and flavor hardship sweet, micro-, temperature, return liver, stomach warp.There is dissipating blood stasis only Blood, effect of subduing swelling and relieving pain, cure mainly spitting of blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.

Stir-baked RHIZOMA CORYDALIS with vinegar, the prepared slices of Chinese crude drugs, pick and process: early summer stem and leaf is excavated when withering.Remove fibrous root, clean, put in boiling water and boil To time just without the white heart, take out, dry.Meridian distribution of property and flavor: temperature；Pungent, bitter；Return liver, spleen channel taboo: anemia of pregnant woman prohibits clothes；The careful clothes of body void person, or With tonic with using.Function cures mainly: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, wrist abdomen pain, amenorrhea dysmenorrhea, postpartum stagnation, fall and flutter Swell and ache.

Oletum Trogopterori, has another name called medicine basis, cold number frass, Oletum Trogopterori etc., is divided into Oletum Trogopterori rice, Oletum Trogopterori block (XUELINGZHI, sugar Oletum Trogopterori) two kinds. The dry feces of the i.e. trogopterus xanthipes Milne-Edwards of Oletum Trogopterori rice, Oletum Trogopterori block is its feces with the mixture of urine folder be dried condensation with a small amount of sandstone and Become.Can be used for blood-stasis internal-depression, escape of blood from meridian hemorrhage, if woman uterine bleeding is through many, color purple polylith, stabbing pain of the lower abdomen.Both can fry by single Grinding into powder, heat wine takes, again can with other drug with the use of, there is effect of blood circulation promoting and blood stasis dispelling.

Radix Salviae Miltiorrhizae, for dry root and the rhizome of labiate Radix Salviae Miltiorrhizae.Spring, season in autumn two excavate, and remove silt, are dried.The whole nation Most area has distribution.Having blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.For the thoracic obstruction heart Bitterly, gastral cavity abdomen hypochondriac pain, the accumulation of abdominal mass abdominal mass, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea, skin infection swells and ache.

Fructus Crataegi (parched to brown), in being born in endroit or mountain region bushes, is distributed in Jiangsu Province, China, Zhejiang, Yunnan, Sichuan, Guangxi Etc. ground.Nature and flavor are sour, sweet, tepor.Return spleen, stomach, Liver Channel.Cure mainly: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty is swollen Full, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain；Hyperlipemia.Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving effect increases By force.For meat stagnation, dysentery is not well.

Olibanum, the resin oozed out for olive subject plant Boswellia carterii and congener bark, nature and flavor are pungent, bitter, temperature.Gui Jing: return The heart, liver, spleen channel.Effect: blood-activating and qi-promoting pain relieving, detumescence and promoting granulation.Cure mainly: for obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, produce Rear stasis blocking, lump in the abdomen stomachache, rheumatic arthralgia, muscle arteries and veins contracture, traumatic injury, carbuncle skin infection.

Myrrha, for olive subject plant Herba Violae tree or the dry resin of Ha Didingshu, is divided into natural Myrrha and gum opoponax.Point It is distributed in the ground such as Somalia, Ethiopia and south, the Arabia Peninsula.There is dissipating blood stasis analgesic therapy, effect of detumescence and promoting granulation.It is usually used in Obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation, abdominal mass suffers from abdominal pain, rheumatic arthralgia, traumatic injury, the disease such as carbuncle skin infection Treatment.

The Radix Linderae, for canella Radix Linderae dried root.The whole year all can excavate, and removes radicula, cleans, takes advantage of fresh slices, dry, Or directly dry.Nature and flavor are pungent, temperature.Gui Jing: return lung, spleen, kidney, bladder warp.Effect: promoting the circulation of QI to relieve pain, warming kidney for dispelling cold.Cure mainly: be used for QI stagnated by cold, chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia pain, through cold stomachache.

Radix Glycyrrhizae, property is sweet flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, it is in harmonious proportion All medicines.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, alleviate Drug toxicity, strong.Radix Glycyrrhizae Preparata is similar round or oval section, and surface red brown or taupe brown are micro-glossy, tangent plane yellow To buff, cambium ring is obvious, ray irradiation shape.Zhigancao decoction has benefiting qi and nourishing yin, and activate yang multiple arteries and veins therapeutic efficiency.

Ramulus Cinnamomi, another name: Liu Gui (formal name used at school: Cinnamomum cassia Presl) is canella Cortex Cinnamomi Cinnamomum The dry twig of cassia Presl.Chinese crude drug Ramulus Cinnamomi is the dry twig of Cortex Cinnamomi, typically gathers in spring, summer, goes disleaf The most directly dry or cut into slices and dry.The pungent temperature of Ramulus Cinnamomi, can cold-dispelling, cold, fever with chills etc. can be treated.Its nature and flavor Acrid, sweet, warm, enter lung, the heart, bladder warp, are to cure mainly the drugs for dispelling internal cold that interior cold is conventional, have complement sun, promoting blood circulation, the merit of warming the spleen and stomach Effect, often with tonifying liver renal drug, fill blood medicine compatibility, treatment insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, with other drugs for dispelling internal cold compatibility Treatment coldness and pain in the epigastrium, arthralgia due to cold lumbago, have significantly analgesia and the effect of anti-cancer and cancer-preventing.Existing various wind dispelling oils medicine is such as Menthocamphorate, rheumatism oil etc. all contain cassia oil composition.Major function: Ramulus Cinnamomi energy diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, cold expelling Pain relieving.Main exterior syndrome due to wind-cold；Arthralgia due to cold-dampnes；Extreme cold of the limbs；Amenorrhea dysmenorrhea；Lump in the abdomen lumps；The thoracic obstruction；Cardiopalmus；Phlegm retention；Dysuria. For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.Usage and dosage: 3～9 grams. Cure mainly " Sullfortrone " leprous i.e. cassia oil of its main component, other side-product of Cortex Cinnamomi such as Ramulus Cinnamomi, Fructus cinnamomi japonici, Fructus cinnamomi immaturus, osmanthus cup etc. There is different pharmacological actions, widely used in Chinese medicine.

" Jing Yue's complete work diarrhea " is said: " having loose bowels originally, invariably due to taste, right kidney is the pass of stomach, and have one's ideas straightened out Yu Eryin, institute Institute with the two all kidneys of folding just is main." spleen kidney be human body successively sky this, the two influences each other.Control suitable warming and recuperating the spleen and kidney, this The Chinese medicine composition of bright offer, with Radix Codonopsis, the Radix Astragali as principal agent, takes its invigorating the spleen and benefiting QI, the effect of consolidating superficial resistance poison holding, minister with the Rhizoma Atractylodis Macrocephalae, Poria, The Rhizoma Atractylodis Macrocephalae is based on the spleen strengthening and damp drying, and Poria is with promoting diuresis to eliminate damp pathogen for wanting, and one is good for one oozes, and spleen can be good for, and wet removes, and wet goes then temper to come again, Yang-energy easily leads to.Rhizoma Dioscoreae is flat mends three the moon, " book on Chinese herbal medicine is looked for the truth ": " enters and preferably gives birth to use in drugs for nourishing yin, enter the spleen reinforcing suitable parching to brown of lung medicine and use." we with Big agent Rhizoma dioscoreae (parched) strengthening the spleen and stomach, tonifying the lung kidney, invigorating the spleen and replenishing QI, spleen invigorating qi-restoratives, be also ministerial drug.Chinese angelica blood supplementing, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae treating blood disorders are lived Blood, medicine-feeding is harmonious, and enriches blood and does not stay the stasis of blood；Pseudo-ginseng hemostatic, Rhizoma Corydalis, Oletum Trogopterori pain relieving；Radix Sophorae Flavescentis dampness removing and diarrhea-relieving；Smooth chest and abdomen are dredged with the Radix Linderae The stagnation of QI, dispelling cold and warming the kidney, Olibanum, Myrrha promoting the circulation of QI to relieve pain；Fructus Crataegi (parched to brown) spleen benefiting and stimulating the appetite, relieving dyspepsia, blood circulation promoting and blood stasis dispelling；Radix Glycyrrhizae, is in harmonious proportion all Medicine.Rhizoma Corydalis, Radix Notoginseng, Olibanum, Myrrha, all medicines such as Fructus Crataegi (parched to brown), Radix Glycyrrhizae phase 5, play Tongmai Huoxue, the merit of the silt pain relieving that disappears altogether, be altogether Help, make.Only this side, QI invigorating ridging, the solid intestinal of spleen invigorating be, has again a meaning of replenishing and activating blood, strengthening the spleen to promote digestion, hemostasis and pain-relieving, therefore energy Make the dirty dirt of gastrointestinal go, taste stagnant disappear, between intestinal blood stasis and all diseases from removing.

The Chinese medicine composition for treating ulcerative colitis that the present invention provides, total effective rate is 95%, and its curative effect is excellent In GUCHANG ZHIXIE WAN, the primary symptoms such as diarrhoea, mucopurulent bloody stool, tenesmus all there are is improvement result, diarrhoea, mucopurulent bloody stool are changed Kind effect is better than GUCHANG ZHIXIE WAN, and stool routine examination, CRP are all had improvement result, to mucosal inflammation, ulcer, crypt abscess, cup-shaped The pathological changes such as Leukopenia also have improvement result.

The Chinese medicine composition being used for treating ulcerative colitis of present invention offer can make decoction, after making decoction, Not only good absorbing, effect is notable, easily portable.Meanwhile, this Chinese medicine composition can also make granule, and relatively liquid decoction is more It is easy to carry.,

Detailed description of the invention

Embodiment 1

A kind of Chinese medicine composition for treating ulcerative colitis, it is characterised in that include following former by weight Material: Radix Codonopsis 30g, Radix Astragali 30g, Radix Sophorae Flavescentis 6g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 45g, Poria 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 12g, Radix Notoginseng 3g, vinegar Rhizoma Corydalis 10g, Oletum Trogopterori 6g, Radix Salviae Miltiorrhizae 12g, Fructus Crataegi (parched to brown) 12g, Olibanum 10g, Myrrha 10g, Radix Linderae 10g, Radix Glycyrrhizae Preparata 6g.

Embodiment 2

A kind of Chinese medicine composition for treating ulcerative colitis, includes following raw material by weight: Radix Codonopsis 25g, Radix Astragali 35g, Radix Sophorae Flavescentis 7g, Rhizoma Atractylodis Macrocephalae 17g, Rhizoma Dioscoreae 40g, Poria 12g, Radix Angelicae Sinensis 12g, Radix Paeoniae Rubra 14g, Radix Notoginseng 5g, stir-baked RHIZOMA CORYDALIS with vinegar 12g, five Oletum Trogopterori 8g, Radix Salviae Miltiorrhizae 10g, Fructus Crataegi (parched to brown) 10g, Olibanum 12g, Myrrha 12g, Radix Linderae 8g, Radix Glycyrrhizae Preparata 8g.

Embodiment 3

A kind of Chinese medicine composition for treating ulcerative colitis, includes following raw material by weight: Radix Codonopsis 35g, Radix Astragali 25g, Radix Sophorae Flavescentis 4g, Rhizoma Atractylodis Macrocephalae 13g, Rhizoma Dioscoreae 50g, Poria 8g, Radix Angelicae Sinensis 8g, Radix Paeoniae Rubra 10g, Radix Notoginseng 1g, stir-baked RHIZOMA CORYDALIS with vinegar 7g, Oletum Trogopterori 4g, Radix Salviae Miltiorrhizae 14g, Fructus Crataegi (parched to brown) 15g, Olibanum 8g, Myrrha 8g, Radix Linderae 13g, Radix Glycyrrhizae Preparata 4g.

Embodiment 4

A kind of Chinese medicine composition for treating ulcerative colitis, includes following raw material by weight: Radix Codonopsis 30g, Radix Astragali 30g, Radix Sophorae Flavescentis 6g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 45g, Poria 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 12g, Radix Notoginseng 3g, stir-baked RHIZOMA CORYDALIS with vinegar 10g, five Oletum Trogopterori 6g, Radix Salviae Miltiorrhizae 12g, Fructus Crataegi (parched to brown) 12g, Olibanum 10g, Myrrha 10g, Radix Linderae 10g, Radix Glycyrrhizae Preparata 6g, Ramulus Cinnamomi 10g.

Embodiment 5

A kind of Chinese medicine composition for treating ulcerative colitis, includes following raw material by weight: Radix Codonopsis 30g, Radix Astragali 30g, Radix Sophorae Flavescentis 6g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 45g, Poria 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 12g, Radix Notoginseng 3g, stir-baked RHIZOMA CORYDALIS with vinegar 10g, five Oletum Trogopterori 6g, Radix Salviae Miltiorrhizae 12g, Fructus Crataegi (parched to brown) 12g, Olibanum 10g, Myrrha 10g, Radix Linderae 10g, Radix Glycyrrhizae Preparata 6g, Ramulus Cinnamomi 13g.

Embodiment 6

A kind of Chinese medicine composition for treating ulcerative colitis, includes following raw material by weight: Radix Codonopsis 30g, Radix Astragali 30g, Radix Sophorae Flavescentis 6g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 45g, Poria 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 12g, Radix Notoginseng 3g, stir-baked RHIZOMA CORYDALIS with vinegar 10g, five Oletum Trogopterori 6g, Radix Salviae Miltiorrhizae 12g, Fructus Crataegi (parched to brown) 12g, Olibanum 10g, Myrrha 10g, Radix Linderae 10g, Radix Glycyrrhizae Preparata 6g, Ramulus Cinnamomi 8g.

Embodiment 7

A kind of Chinese medicine granules for treating ulcerative colitis, it is dry by embodiment 1-6 arbitrary described compositions warp Dry, pulverize, pelletize prepare.

Embodiment 8

A kind of Chinese medicine decoction for treating ulcerative colitis, it is added decocting by the arbitrary described compositions of embodiment 1-6 Prepare.

Specially take after 1000ml water mixes with Chinese medicine composition, put into and marmite medicinal cupping is carried out decoct 4h, obtain 600ml soup Medicament, is then classified as three parts of 250ml, 250ml, 100ml, and two parts of 250ml are each oral portion, 100ml agent sooner or later Amount coloclysis.

Clinical trial:

1, respondent and method

In April, 2005 in July, 2007 No.1 Hospital Attached to He'nan Traditional Chinese Medical College is met differential diagnosis in tcm is blood stasis and gas The outpatient service of empty (yang deficiency) type UC and inpatient is randomly divided into treatment group 120 example by 1:1 and matched group 120 example is observed.

2, diagnostic criteria

2.1 clinical manifestation diagnostic criterias

Having persistence or recurrent exerbation mucosanguineous feces, stomachache, with General Symptoms in various degree.And, should not ignore Minority without in hemafecia, or the patient of only constipation, history of past illness or health check-up it is noted that intestinals such as joint, eye, oral cavity, skin, liver, spleens Outer performance.

2.2 colon-endoscope diagnosis standards

(1) mucosa has multiple fester, and companion is congested, edema, and pathological changes mostly starts from rectum and is distributed in diffusivity；

(2) mucosa is coarse in fine particulate, and mucosa blood vessel obscures, crisp the most hemorrhage, or with purulent secretion；

(3) false polyp seen from, haustra of colon rust or disappearance.

2.3 intestinal mucosa pathological biopsy diagnostic criterias

Histological examination is inflammatory reaction, with visible erosion often, ulcer, crypt abscess, body of gland arrangement extremely, cherishes shape Leukopenia and epithelium change.

2.4 clysis with barium x-ray diagnostic criterias

(1) mucosa slightly unrest and/or have fine grained to change；

(2) multiple ulcer or false polyp；

(3) intestinal tube narrow, shorten, haustra of colon disappear, can be in a tubular form.

2.5 excisions or pathological anatomy visual or histological ulcerative colitis feature

The ulcerative colitis cause of disease is complicated, lacks specific pathologies and changes and typical clinical manifestation, the most tired in diagnosis Difficult.Get rid of the caused infectious colitis such as bacillary dysentery, ameba enteritis, chronic schistosomiasis, pulmonary tuberculosis and colon Crohn disease, On the basis of radiation colitis, by following diagnostic criteria:

1. according to clinical manifestation, colonoscopy it (1), (2), one of (3) three items and (or) Mucosa Biopsy are permissible Diagnosis primary disease.Observe equal row biochemical analysis before case treatment: routine blood test, stool routine, C reactive protein etc..

2. one of (1), (2) or (3) item person is had can to diagnose primary disease according to clinical manifestation and clysis with barium.

3. its atypical clinical manifestations and have typical colonoscope performance or barium enema check typical case changer, can diagnose Primary disease.

4. clinical manifestation has classical symptom or typical case's history of past illness, and colonoscope or barium enema inspection there is no typical case and change at present Change person, should be classified as " doubt and examine " and follow up a case by regular visits to.

5. setting out case, clinical manifestation and colonoscope change the person that is not all true to type, and wouldn't be diagnosed as ulcerative colitis, can be with Visit 3-6 month, observe outbreak situation.

2.6 Clinical types diagnostic criterias

(1) first hair style: degrees of symptoms difference can be changed into chronic relapsing or chronic sustained type.

(2) chronic sustained type: often have the diarrhoea of lasting weight not grade, interruption to have blood in stool, suffer from abdominal pain and whole body disease after First-episode Shape, the course of disease is many more than 6 months, and pathological changes often involves total colectomy, and majority has ulcer and false polyp to be formed, and severe patient can occur Toxic megacolon and intestinal perforation, and thrombophlebitis can occur.Due to state of an illness weight, the persistent period is long, and patient may occur in which lean Blood, become thin, and the later stage easily occurs canceration.

(3) chronic relapsing: clinical common, symptom is relatively light, recurrent exerbation.In the course of disease general 3-10 week, suffer from diarrhoea 3-5 time every day Mucous Stool, pus just or have hemafecia.General Symptoms is inconspicuous, shows typical change, intermission mucosa in stage of attack enteroscopy Mild hyperaemia, edema.Pathologic diagnosis shows chronic inflammatory disease, time light time weight.This type can transfer chronic sustained type to.

(4) acute fulminant form: this type is more rare, accounts for 2.6%, and onset is hurried, multiple teenager of being born in, whole body and local Symptom is all serious, and high heat is up to 40 DEG C, and bloody purulent stool or hemafecia every day, up to more than 20 times, are often accompanied by anemia, Nausea and vomiting, abdomen , easily there is the complication such as toxic colonic dilatation, intestinal perforation, peritonitis in the toxemia performances such as swollen, tachycardia.Colonoscopy Pathological changes is notable, and mortality rate is 10%～15%, general many generation, these type prognosis malas in after being ill 2 years.

Chronic sustained type and chronic relapsing (active stage) ulcerative colitis are only studied in this test.

2.7 Chinese medical discrimination blood stasis and the symptom standard of the deficiency of vital energy (even yang deficiency)

(1) blood stasis: abdomen localized pain, or tenderness, there is mass in the abdomen local, just band pus and blood or blood, purplish tongue or have ecchymosis Petechia, hesitant pulse or string.

(2) deficiency of vital energy (yang deficiency): soft stools, is mingled with mucus, and with pus and blood or blood, lusterless complexion or white, limbs are tired Idle, few food lazyness speech, the most then i.e. to rush down dawn, fear of cold, cold pain in abdomen, light red tongue, tongue is the most greasy, arteries and veins or thin.

Above binomial is respectively shown in that one symptom is two diseases and has concurrently.

2.8 condition-inference standards: be shown in Table 1.

Table 1 ulcerative colitis condition-inference standard

Scoring method: (+), (+), (+++) count 1,2,3 points respectively.

2.9 extent of disease diagnostic criterias

Extent of disease is determined according to x-ray inspection or fibercolonscopy.This problem does not study pancolitis, only under research State extent of disease.

(1) RS: pathological changes is confined to rectum, or rectum and sigmoid colon.

(2) LC: refer to that hepatic flexure of colon is got involved with remote colon, i.e. each section of colon of rectum, sigmoid colon, descending colon, even transverse colon.

(3) RC: inflammation is confined to ascending colon and caecum.

2.10 intestinal mucosal lesion grading diagnosis standards: be shown in Table 2.

2.11 syndrome diagnostic criterion

What this problem only studied UC belongs to blood stasis and the deficiency of vital energy (even yang deficiency) card person.Its diagnostic criteria is as follows:

(1) primary symptom: 1. abdominal pain diarrhea mucopurulent bloody stool；2. tenesmus；3. pale tongue tongue is the most greasy or purplish tongue has the stasis of blood Speckle；4. hesitant pulse or string or or thin.

(2) secondary disease: 1. abdominal pain with tenderness；2. there is mass in the abdomen local；3. lusterless complexion or white；4. limbs asthenia；Eat lazyness less Speech；The most then diarrhea before dawn, cold pain in abdomen；7. poor appetite；8. slip；9. borborygmus；10. burning sensation of the anus；Intestinal mucosa is congested, rotten to the corn and Hemorrhage substantially.

Possess primary symptom binomial (Section 1 is indispensable) and time disease three, or primary symptom Section 1 is i.e. established with secondary disease 3, diagnosis.

Table 2 UC patient's intestinal mucosal lesion grading diagnosis standard

Scoring method: (+), (++), (+++) count l, 2,3 point respectively.

(3) Syndrome Scale: be shown in Table 3.

Table 3 UC patient clinical Syndrome Scale

Scoring method: (+), (++), (+++), respectively in terms of l, 2,3 point.

2.12 Differential Diagnosis

(1) chronic bacillary dysentery: often have acute dysentery medical history, stool cultivation to may separate out dysentery bacterium, antibacterials Treatment is effectively.

(2) chronic ameba enteritis: colon on the right side of the infringement of pathological changes length, also can involve left side colon, being dispersed in property ulcer, burst Infections edge moves under water, ulcer deep, and the many genus of mucosa between ulcer are normal.Stool can find amoeba trophozoite and encapsulation, passes through colon Mirror takes ulcer surface exudate or ulcer edge biopsy to look for amoeba trophozoite positive rate high.The treatment of anti-ameba is effectively.

(3) schistosomicide: patient has Infested-water contact history, hepatosplenomegaly, stool examination can find worm's ovum, stool for hatching hair The larva of a tapeworm or the cercaria of a schistosome can help to make a definite diagnosis, and colonoscope takes tissue slice and can find worm's ovum sometimes.

(4) diverticulosis of colon: can have intermittent hypogastric region angor, suffer from diarrhoea, generate heat, even have blood in stool, amount of bleeding is more；Barium fills Intestinal shows multiple diverticulum.This disease sickness rate at home is relatively low.

(5) colon cancer: after being mainly in the middle age, colonoscopy and barium enema inspection are helpful to Differential Diagnosis, group Knit pathological examination can clarify a diagnosis.

(6) irritable bowel syndrome: the course of disease is longer, systemic conditions is good, has intermittent stomachache, diarrhoea, and feces is without blood, nothing Heating.Colonoscopy and histopathological examination change without exception, barium enema examination display spastic colon, bag-shaped intensive etc. levy As.

Additionally, also should distinguish that shuttle shape bacillus enteritis, colon cease with Ischemic Colitis, pseudomembranous enteritis, tuberculosis of intestine, difficulty Disease of muscle, diverticulitis of colon, radioactivity coloproctitis etc. differentiate.

3, include in and exclusion standard

3.1 inclusive criteria

(1) ulcerative colitis Western medicine diagnose standard person is met；

(2) meet differential diagnosis in tcm and have blood stasis and the pathogenesis of the deficiency of vital energy (yang deficiency) concurrently；

(3) Clinical types is chronic sustained type or chronic relapsing (active stage)；

(4) age is in 18 one full year of life one full year of life 65, male or female；

(5) three stool antibacterial culturing negative patients.

3.2 exclusion standard

(1) person that do not meets inclusive criteria；

(2) gestation or women breast-feeding their children, allergic constitution and to observe medicine allergy sufferers；

(3) the severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, psychotic it are associated with；

(4) there are bowel narrow, intestinal obstruction, intestinal perforation, rectal polyp, toxic colonic dilatation, colon and rectum carcinoma and anus Door disease patient；Acute fulminant form UC, severe UC patient；

(5) not by regulation medication, or this test has been failed, the person of dropping by the wayside.

4, sample content

The estimation of sample content makees sample by " difference of two rates is done required size when statistical significance is checked " Estimating, this method acceptance rate is 90%, and matched group acceptance rate is 74%, then p1=0.90, p2=o.74, б=0.16, take α= 0.05, β=0.10, unilateral μ α=1.645, μ β=1.282, calculate by following equation: n=(μ α+μ β) 22p (1-p)/(p1- P2) 2, p=(p1+p2)/2, n=100, by rate 20% lost to follow-up, then total case load is: 100 × 2 × 120%=240 example.

5, sampling approach

Random Design: select to meet patient 240 example of diagnosis and inclusive criteria, be randomly divided into test group and matched group, often Organize 120 examples, be grouped by table of random number according to medical order.Enumeration data X²Inspection, normal distribution measurement data F checks, Whether using F to check further according to homogeneity of variance after the leading Logarithm conversion of partial velocities measurement data, ranked data RIDIT divides Analysis.This test cannot use double-blind method, therefore uses mono blind method.

Test group uses the Chinese medicine composition that the embodiment of the present invention 1 provides, decocting 600ml, sooner or later respectively takes 250ml, protects Stay 100ml coloclysis.Yang deficiency symptom adds Ramulus Cinnamomi 10g on the basis of embodiment 1, is the compositions that embodiment 4 provides.

Matched group: oral GUCHANG ZHIXIE WAN (Pharmacy Factory of Shanxi Chinese Medicine College) 9g, takes every day in three times.

Above two groups was all a course for the treatment of with 15 days, observed four courses for the treatment of altogether, during observing according to or without infecting, lean The symptomatic treatments such as blood, electrolyte disturbance, hypoproteinemia, the most monthly follow up a case by regular visits to once, 6 months totally, observation late result, Untoward reaction and complication.

7.1 physical data

In 240 examples, treatment group 120 example, male 64 examples, female 56 example；21 65 years old age, average 45.30 ± 12.07: the course of disease 6 Individual month 24 years, average 11.12 ± 6.34 years.

Matched group 120 example, male 65 examples, female 55 example；22 65 years old age, average 44.06 ± 11.42；The course of disease 3 months 30 Year, average 10.12 ± 6.44 years.

7.2 treat front two groups of case comparabilities

7.2.1 physical data comparability: refer to table 4, table 5, table 6.

Table 4 clinical research case Sex distribution statistical table

Treatment group and matched group sex situation are through non parametric tests, P > 0.05, it is not statistically significant, two groups of cases are described Sex distribution situation has comparability.

Table 5 clinical research case age distribution statistical table (unit: year)

Through between non parametric tests two groups, age distribution situation compares P > 0.05, it is not statistically significant, two groups of cases are described Age distribution situation has comparability.

Table 6 clinical research case course of disease distribution statistics table (unit: year)

Through between non parametric tests two groups, age distribution situation compares P > 0.05, it is not statistically significant, two groups of cases are described Course of disease distribution situation has comparability.

7.2.2 Clinical types, extent of disease and severity extent comparability: be shown in Table 7.

7 liang of table group case Clinical types and extent of disease compare

Through X²Inspection and variance analysis, two groups of case Clinical types and extent of disease and severity extent integration are poor without significance Different (P > 0.05).

7.3 therapeutic outcome

7.3.1 two groups of Clinical efficacy comparisons: be shown in Table 8.

8 liang of table group Clinical efficacy comparison

Through between rank test, group, general curative effect compares P < 0.05, statistically significant, illustrates that treatment group curative effect is substantially better than Control drug GUCHANG ZHIXIE WAN.Between group, cure rate compares P < 0.05 through X 2 test, illustrates that blood stasis and gas are treated in activating blood circulation and supplementing qi ruling by law Empty (yang deficiency) type ulcerative colitis, is better than GUCHANG ZHIXIE WAN to eliminating or improving the effect of its clinical symptoms.

7.3.2 clinical symptoms is improved: be shown in Table 9.

Primary symptom integral contrast table (x before and after the group treatment of 9 liang of table²±s)

Check (paired sample compares) through t, treat front two groups of each primary symptom integral mean values and there was no significant difference (P > 0.05)；Control After treatment, two groups of each primary symptoms all have clear improvement (P < 0.05), illustrate that Huoxueyiqi and GUCHANG ZHIXIE WAN all can significantly reduce trouble Person's clinical symptoms integration, improves blood stasis and the clinical symptoms of the deficiency of vital energy (yang deficiency) type ulcerative colitis.Particularly treatment group is at abdomen Rush down, the improvement degree of the primary symptom such as Mucous Stool is better than matched group (P < 0.05).

7.3.3 fibro-colonoscope intuitively changes: be shown in Table 10.

Before and after the group treatment of 10 liang of table, colonoscopy intestinal mucosal lesion compares (x²±s)

Before treatment, two groups of intestinal mucosal lesions there was no significant difference (P > 0.05)；After treatment, two groups of intestinal mucosal lesions are the most notable Improving (P < 0.05), treatment group improvement degree is better than matched group (P < 0.05).

7.3.4 intestinal mucosa pathology improves: be shown in Table 11.

The group treatment ideocolon mucosa pathological change of 11 liang of table

Through X²Inspection, two groups of mucosal inflammation elimination factors, ulcer elimination factors there was no significant difference (P > 0.05).Treatment group crypts Abscess, goblet cell reduce elimination factor higher than matched group (P < 0.05).

7.3.5 stool routine examination improves: be shown in Table 12.

Stool routine examination change before and after the group treatment of 12 liang of table

Through X²Inspection, white (pus) cell for the treatment of group and erythrocyte negative conversion rate are above matched group (P < 0.05).

7.3.6CRP change: be shown in Table 13.

CRP change before and after the group treatment of 13 liang of table

Through X²Inspection, two groups of CRP negative conversion rates there was no significant difference (P > 0.05).

7.3.7 the change of other indexs

7.3.7.1 serum IgA, IgM, IgG change: be shown in Table 14.

Before and after the group treatment of 14 liang of table, serum IgA, IgM, IgG change (x²±s)

Note: normal value IgG8.0～15.5, IgA736～2960, IgM620～2260

Before treatment, two groups of IgA, IgM are all in range of normal value, and lgG is above range of normal value；Check through F, before treatment All without significant difference (P > 0.05) between IgA, IgM, IgG group.After treatment, treatment group IgG is down to normal range, front more aobvious than having with treating Write sex differernce (P < 0.05)；And matched group IgG remains above normal level, there was no significant difference (P > 0.05) with treating front ratio.

The IgG of result display blood stasis and the deficiency of vital energy (even yang deficiency) patients of ulcerative colitis raises.This type patient of prompting deposits Hyperfunction in humoral immunization, and activating blood circulation and supplementing qi method can substantially reduce the IgG of abnormal rising, prompting originally can suppress abnormal body fluid to exempt from Epidemic disease, has immunoregulation effect.

7.3.7.2 intestinal SlgA change: be shown in Table 15.

Before and after the group treatment of 15 liang of table, intestinal SlgA changes (x²±s)

Note: intestinal slgA normal value is 2.6 ± 1.9mg/g.

Before treatment, two groups of intestinal SlgA are all remarkably higher than normal value (P<0.05), there was no significant difference (P>0.05) between group: After treatment, treatment group intestinal slgA significantly reduces (P<0.05), and matched group reduces (P>0.05) without significance；The reduction for the treatment of group Effect is better than matched group (P < 0.05).

Blood stasis and the deficiency of vital energy (even yang deficiency) type patients of ulcerative colitis feces SlgA content significantly raise.This may be with intestinal Antibacterial, toxin or other harmful antigens material incentive intestinal mucosal immune system in road, makes SlgA secretion increase relevant.SlgA can Mucous membrane of colon pathology damage effect can be participated in as autoantibody.The above results shows, activating blood circulation and supplementing qi method can significantly reduce intestinal SlgA content, its result may alleviate SlgA by the ADCC effect damage to intestinal mucosa.

7.3.7.3 serum TNF-, IL-6, IL-8 level change: be shown in Table 16.

Table 16 treatment before and after serum TNF-, IL-6, IL-8 change (x²±s)

Serum TNF after treatment-, IL-6, IL-8 level substantially reduce (P < 0.05) before relatively treating.

The cytokine such as TNF-, IL-6, IL-8 in blood stasis and the deficiency of vital energy (even yang deficiency) type patients of ulcerative colitis serum Horizontal compared with normal significantly raises, and the reason of rising is likely due in this type patient's blood there is autoantibody and immune complex, Merging antibacterial to infect, autoantibody immune complex and bacterial antigens stimulate monokaryon one macrophage to produce by different approaches simultaneously Give birth to and discharge TNF-in blood circulation, causing blood TNF-level to increase；T cell and mononuclear phagocyte are by bacterial endotoxin And the stimulation of TNF-produces and discharges IL-6, IL-8 thus cause IL-6, IL-8 level in blood to increase.TNF-ɑ、IL-6、IL-8 It is raised through above-mentioned mechanism of action, produces a series of pathological change, cause the inflammation damnification of intestinal mucosa.After treatment by Chinese herbs, suffer from In person's blood, TNF-, IL-6, IL-8 level is remarkably decreased and there was no significant difference compared with normal person, thus it is speculated that the treatment of Blood rheology Effect mechanism can reduce the amount of autoantibody, immune complex, bacterial antigens, bacterial endotoxin in patient's blood with it, thus reduces Mononuclear phagocyte, release TNF-, IL-6, IL-8 are relevant for T cell.

Sum up:

The traditional Chinese medicine composition for treating blood stasis of present invention offer and the total effective rate of the deficiency of vital energy (yang deficiency) type ulcerative colitis 95%, the total effective rate of matched group is 87.5%.The two is compared, and the curative effect for the treatment of group is better than matched group (P < 0.05).QI invigorating is lived Blood method to blood stasis and the primary symptom such as the deficiency of vital energy (yang deficiency) type patients of ulcerative colitis stomachache, diarrhoea, mucopurulent bloody stool and tenesmus, Picture of the tongue, pulse condition are significantly improved, and its effect is better than matched group (P < 0.05), and Blood rheology is to patients of ulcerative colitis The pathological changes such as mucosal inflammation, ulcer, crypt abscess, goblet cell minimizing all have improvement result, but compared with matched group, invigorate blood circulation Invigorating Qi is only to patient's crypt abscess, and the improvement situation that goblet cell reduces is better than matched group (P < 0.05), to patient's mucositis Disease, the improvement situation of ulcer and matched group are quite (P > 0.05).Blood rheology is to patients of ulcerative colitis stool routine examination Improve and reduce the effect of the CRP raised, compare with matched group and there was no significant difference (P > 0.05).Blood rheology is different to patient The serum IgG and the intestinal SlgA that often raise are respectively provided with reduction effect, and are better than matched group (P < 0.05).Patients of ulcerative colitis TNF-, IL-6, IL-8: etc. cytokine, use Blood rheology treatment after its level significantly reduce (P < 0.05).

Claims (6)

1. one kind for treating the Chinese medicine composition of ulcerative colitis, it is characterised in that includes following raw material by weight:

Radix Codonopsis 25-35g, Radix Astragali 25-35g, Radix Sophorae Flavescentis 4-7g, Rhizoma Atractylodis Macrocephalae 13-17g, Rhizoma Dioscoreae 40-50g, Poria 8-12g, Radix Angelicae Sinensis 8- 12g, Radix Paeoniae Rubra 10-14g, Radix Notoginseng 1-5g, stir-baked RHIZOMA CORYDALIS with vinegar 7-12g, Oletum Trogopterori 4-8g, Radix Salviae Miltiorrhizae 10-14g, Fructus Crataegi (parched to brown) 10-15g, Olibanum 8- 12g, Myrrha 8-12g, Radix Linderae 8-13g, Radix Glycyrrhizae Preparata 4-8g.

Chinese medicine composition for treating ulcerative colitis the most according to claim 1, it is characterised in that parts by weights Number also includes Ramulus Cinnamomi 8-13g.

Chinese medicine composition for treating ulcerative colitis the most according to claim 1, it is characterised in that Radix Codonopsis 30g, Radix Astragali 30g, Radix Sophorae Flavescentis 6g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 45g, Poria 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 12g, Radix Notoginseng 3g, stir-baked RHIZOMA CORYDALIS with vinegar 10g, five Oletum Trogopterori 6g, Radix Salviae Miltiorrhizae 12g, Fructus Crataegi (parched to brown) 12g, Olibanum 10g, Myrrha 10g, Radix Linderae 10g, Radix Glycyrrhizae Preparata 6g.

Chinese medicine composition for treating ulcerative colitis the most according to claim 2, it is characterised in that Radix Codonopsis 30g, Radix Astragali 30g, Radix Sophorae Flavescentis 6g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 45g, Poria 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Rubra 12g, Radix Notoginseng 3g, stir-baked RHIZOMA CORYDALIS with vinegar 10g, five Oletum Trogopterori 6g, Radix Salviae Miltiorrhizae 12g, Fructus Crataegi (parched to brown) 12g, Olibanum 10g, Myrrha 10g, Radix Linderae 10g, Radix Glycyrrhizae Preparata 6g, Ramulus Cinnamomi 10g.

Chinese medicine composition for treating ulcerative colitis the most according to claim 1, it is characterised in that described Chinese medicine The dosage form of compositions is granule or decoction.

Chinese medicine composition for treating ulcerative colitis the most according to claim 5, it is characterised in that described decoction Preparation method for above-mentioned each raw material components being added water fried forming, described fried for using 800-1000ml water, with Chinese drug-treated group After compound mixing, fried 2-4h, obtain 570-630ml decoction.