CN106153543A - A kind of online ultraviolet detector of automated fluid - Google Patents
A kind of online ultraviolet detector of automated fluid Download PDFInfo
- Publication number
- CN106153543A CN106153543A CN201610846030.3A CN201610846030A CN106153543A CN 106153543 A CN106153543 A CN 106153543A CN 201610846030 A CN201610846030 A CN 201610846030A CN 106153543 A CN106153543 A CN 106153543A
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- China
- Prior art keywords
- ultraviolet
- probe
- automated fluid
- online
- spectrometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012530 fluid Substances 0.000 title claims abstract description 15
- 238000005070 sampling Methods 0.000 claims abstract description 35
- 239000000523 sample Substances 0.000 claims abstract description 28
- 239000007788 liquid Substances 0.000 claims abstract description 22
- 239000003085 diluting agent Substances 0.000 claims abstract description 19
- 239000013307 optical fiber Substances 0.000 claims abstract description 16
- 239000000872 buffer Substances 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims description 16
- 239000012895 dilution Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 12
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 238000003786 synthesis reaction Methods 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000000284 extract Substances 0.000 description 3
- 238000000825 ultraviolet detection Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 229930191701 arteannuin Natural products 0.000 description 1
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 description 1
- 229960004191 artemisinin Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
Landscapes
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of online ultraviolet detector of automated fluid, including the diluent buffer barrel contacted successively by main line, diluent feed pump, first probe, threeway and the second probe, described first probe is connected to the first ultraviolet source and the first ultraviolet spectrometer by optical fiber, described second probe is connected to the second ultraviolet source and the second ultraviolet spectrometer by optical fiber, described first ultraviolet spectrometer and the second ultraviolet spectrometer are connected with industrial computer by cable, described threeway is connected by branch line sampling baffle-box, described sampling baffle-box connects extracting solution intake line.The present invention can realize efficiently for the liquid component sampled, fully-automated synthesis process fast, accurately, to avoid anthropic factor for detecting the impact of process.
Description
Technical field
The present invention relates to modernization of Chinese medicine extractive technique field, particularly relate to a kind of automated fluid online ultraviolet detection dress
Put.
Background technology
Herbal pharmaceutical is the important component part of China's medicinal industry, has been written in made in China 2025 strategical planning,
Promote the target of its processing and manufacturing level and have gone up as national strategy height, complete in socio-economic development of modernization of Chinese medicine technology
Have great significance in Ju.Chinese Traditional Medicine is given the present arteannuin of the people of the world and is obtained Nobel's physiology in 2015
Learning and Medicine, this further illustrates modern Chinese medicine and is expected to become China and has international competitiveness and have independent intellectual property right
One of specialty industries.But at present, it is uneven generally to there is tcm product quality between batch in the herbal pharmaceutical industry of China, Chinese medicine
Untoward reaction accident is reported in media often, and causing the main cause of herbal medicine efficacy and quality fluctuation phenomenon is extraction of traditional Chinese medicine
The unstability of product quality.In tcm product manufacture process, technology for extracting effective component is as the raw material production of Chinese patent medicine
Stage and primary link, play very important effect to end product quality.At present, Traditional Chinese medicine extraction method based on extraction,
Suitable solvent (water, ethanol etc.) is i.e. used to pass through the processes such as decoction within the time of regulation by the extracts active ingredients in medical material
Separate.In this technical process, the quality fluctuation phenomenon that different batches extracts product is the most obvious, and this is due to following two side
Face is caused: first, Chinese crude drug complicated component, and its contained various compositions are easily naturally grown bar by the place of production, weather etc.
Part affects and produces change;Secondly, Modernized technology for processing Chinese herbal medicine level is relatively low, and production process operation is extensive, it is impossible in along with
Medicine raw material batch difference and adjust extracting factor at any time.
Therefore, designing and provide a kind of strength of fluid automatic detection device that can automatically, accurately sample is that Chinese medicine is modern
Change the technical problem that extractive technique field is urgently to be resolved hurrily.
Summary of the invention
The invention aims to overcome deficiency of the prior art, it is provided that a kind of automated fluid online ultraviolet detection dress
Put, can realize efficiently for the liquid component sampled, fully-automated synthesis process fast, accurately, to avoid anthropic factor
For detecting the impact of process.
It is an object of the invention to be achieved through the following technical solutions.
The online ultraviolet detector of a kind of automated fluid of the present invention, is delayed including the diluent contacted successively by main line
Rushing bucket, diluent feed pump, the first probe, threeway and the second probe, described first probe is connected to first by optical fiber
Ultraviolet source and the first ultraviolet spectrometer, described second probe is connected to the second ultraviolet source and the second ultraviolet by optical fiber
Spectrogrph, described first ultraviolet spectrometer and the second ultraviolet spectrometer are connected with industrial computer by cable, and described threeway is by dividing
Bye-pass connects sampling baffle-box, and described sampling baffle-box connects extracting solution intake line.
Described sampling baffle-box top is provided with air filter, is provided with optical-fiber liquid level gauge in described sampling baffle-box.
It is provided with the first electromagnetic valve between described diluent feed pump and the first probe.
Described branch line is provided with the second electromagnetic valve.
Described extracting solution intake line is provided with sampling pump and the 3rd electromagnetic valve along feed liquor direction.
Described first ultraviolet source and the first ultraviolet spectrometer lay respectively at the both sides of main line.
Described second ultraviolet source and the second ultraviolet spectrometer lay respectively at the both sides of main line.
Compared with prior art, technical scheme is had the benefit that
(1) in the present invention, by threeway and diluent feed pump to realize sample liquid automatization, accurate, stable
Diluting effect;
(2), in the present invention, the diluent detected is absorbed the incoming industry control of signal of New UV Spectrophotometric by the first ultraviolet spectrometer
Machine, the mixed solution (diluent and extracting solution) detected is absorbed the incoming industry control of signal of New UV Spectrophotometric by the second ultraviolet spectrometer
Machine, obtains this extracting solution by data analysis and absorbs the data of New UV Spectrophotometric, and the automatization i.e. completing extracting solution concentration of component adopts
Collection work;
(3), in the present invention, air filter is contained in above sampling baffle-box, in order to prevent the dust in air from falling into sampling
In baffle-box;
(4) in the present invention, in sampling baffle-box, it is provided with optical-fiber liquid level gauge, when the extracting solution liquid level in sampling baffle-box reaches
During to specified altitude assignment, optical-fiber liquid level gauge can experience liquid level change, sends electronic signal, closes sampling pump, and sampling can be prevented slow
Rush the too high spilling of the liquid level in case.
Accompanying drawing explanation
Fig. 1 is the structural representation of the present invention.
Reference: 1 diluent buffer barrel;2 diluent feed pumps;3 first probes;4 threeways;5 main lines;6 second visit
Head;7 optical fiber;8 first ultraviolet sources;9 first ultraviolet spectrometers;10 second ultraviolet sources;11 second ultraviolet spectrometers;12 electricity
Cable;13 industrial computers;14 branch lines;15 sampling baffle-boxs;16 extracting solution intake lines;17 air filters;18 optical fiber liquid levels
Instrument;19 first electromagnetic valves;20 second electromagnetic valves;21 sampling pumps;22 the 3rd electromagnetic valves.
Detailed description of the invention
For making the purpose of patent of the present invention, feature become apparent, the concrete reality to patent of the present invention below in conjunction with the accompanying drawings
The mode of executing is further described.It should be noted that, accompanying drawing all uses the form simplified very much and all uses non-ratio accurately,
Only in order to purpose convenient, aid illustration patent Example of the present invention lucidly.
As it is shown in figure 1, the online ultraviolet detector of a kind of automated fluid of the present invention, dense in order to realize for liquid component
Degree on-line automaticization ultraviolet detection, including the diluent buffer barrel 1 contacted successively by main line 6, diluent feed pump 2,
First probe 3, threeway 4 and the second probe 6, be provided with the first electromagnetic valve between described diluent feed pump 2 and the first probe 3
19.Described first probe 3 is connected to the first ultraviolet source 8 and the first ultraviolet spectrometer 9 by optical fiber 7, and described first is purple
Outer light source 8 and the first ultraviolet spectrometer 9 lay respectively at the both sides of main line 5, and described second probe 6 is connected respectively by optical fiber 7
There is the second ultraviolet source 10 and the second ultraviolet spectrometer 11, described second ultraviolet source 10 and the second ultraviolet spectra 11 instrument position respectively
In the both sides of main line 5, described first ultraviolet spectrometer 9 and the second ultraviolet spectrometer 11 are respectively by cable 12 and industrial computer 13
Connect.The another port of described threeway 4 is also associated with sampling baffle-box 15 by branch line 14, and described branch line 14 is arranged
The second electromagnetic valve 20, described sampling baffle-box 15 top is had to be provided with air filter 17, in order to prevent the dust in air from falling
Entering to sample in baffle-box 15, described sampling baffle-box 15 is internally installed optical-fiber liquid level gauge 18, and described sampling baffle-box 15 connects
Having extracting solution intake line 16, described extracting solution intake line 16 is provided with sampling pump 21 and the 3rd electromagnetic valve along feed liquor direction
22。
Described optical-fiber liquid level gauge 18 is preferably arranged in the 2/3-4/5 altitude range of described sampling baffle-box 15, works as sampling
When liquid level in baffle-box 15 arrives the 2/3-4/5 of whole casing level height, optical-fiber liquid level gauge 18 can be experienced liquid level and become
Change, send electronic signal, close sampling pump 21, so can prevent from sampling the too high spilling of liquid level in baffle-box 15.
The present invention is arranged on Chinese medicine extracting tank side, and from extraction pot tank body, open pipe is connected with described sampling pump 21, when needing
When extract concentration being detected, open described sampling pump 21, open the 3rd electromagnetic valve 22, make the extracted liquid of extracting solution defeated
Entering pipeline 16 and flow in described sampling baffle-box 15, the first electromagnetic valve 19 and the second electromagnetic valve 20 in the present invention are in closing
State;After the liquid in described sampling baffle-box 15 arrives and specifies liquid level, sampling pump 21 is closed;The first electricity on main line 5
Magnet valve 19 is opened, and described diluent feed pump 2 is opened, and diluent flows out from described diluent buffer barrel 1, flows along main line 5
Go out;When, after diluent flow a period of time, the second electromagnetic valve 20 on branch line 14 is opened, and extracting solution is under gravity
Flow in main line 5 from sampling baffle-box 15;Described first ultraviolet source the 8, second ultraviolet source the 10, first ultraviolet spectrometer 9
It is energized unlatching with the second ultraviolet spectrometer 11 simultaneously, automatically detects and record and on main line 5, connect the first probe 3 and the second probe
The detection signal that 6 record, is analyzed incoming for this signal industrial computer 13, visits the first probe 3 and second in industrial computer 13
The detection signals that 6 record carry out following process, with the first probe 3 the signal that obtains of detection come second for blank signal
The signal that probe 6 records is modified, and i.e. can obtain this extracting solution and absorb the data of New UV Spectrophotometric, i.e. complete an extracting solution group
Divide the automation collection work of concentration.
Although function and the work process of the present invention being described above in conjunction with accompanying drawing, but the invention is not limited in
Above-mentioned concrete function and work process, above-mentioned detailed description of the invention is only schematic rather than restrictive, ability
The those of ordinary skill in territory is under the enlightenment of the present invention, without departing from present inventive concept and scope of the claimed protection situation
Under, it is also possible to make a lot of form, within these belong to the protection of the present invention.
Claims (7)
1. the online ultraviolet detector of automated fluid, it is characterised in that include the dilution contacted successively by main line (5)
Liquid buffer barrel (1), diluent feed pump (2), the first probe (3), threeway (4) and the second probe (6), described first probe (3)
Being connected to the first ultraviolet source (8) and the first ultraviolet spectrometer (9) by optical fiber (7), described second probe (6) passes through light
Fine (7) are connected to the second ultraviolet source (10) and the second ultraviolet spectrometer (11), described first ultraviolet spectrometer (9) and the
Two ultraviolet spectrometers (11) are connected with industrial computer (13) by cable (12), and described threeway (4) is connected by branch line (14)
Having sampling baffle-box (15), described sampling baffle-box (15) connects extracting solution intake line (16).
A kind of online ultraviolet detector of automated fluid the most according to claim 1, it is characterised in that described sampling buffers
Case (15) top is provided with air filter (17), is provided with optical-fiber liquid level gauge (18) in described sampling baffle-box (15).
A kind of online ultraviolet detector of automated fluid the most according to claim 1, it is characterised in that described diluent enters
It is provided with the first electromagnetic valve (19) between material pump (2) and the first probe (3).
A kind of online ultraviolet detector of automated fluid the most according to claim 1, it is characterised in that described branch line
(14) the second electromagnetic valve (20) it is provided with.
A kind of online ultraviolet detector of automated fluid the most according to claim 1, it is characterised in that described extracting solution is defeated
Enter pipeline (16) and be provided with sampling pump (21) and the 3rd electromagnetic valve (22) along feed liquor direction.
A kind of online ultraviolet detector of automated fluid the most according to claim 1, it is characterised in that described first ultraviolet
Light source (8) and the first ultraviolet spectrometer (9) lay respectively at the both sides of main line (5).
A kind of online ultraviolet detector of automated fluid the most according to claim 1, it is characterised in that described second ultraviolet
Light source (10) and the second ultraviolet spectrometer (11) lay respectively at the both sides of main line (5).
Priority Applications (1)
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CN201610846030.3A CN106153543A (en) | 2016-09-23 | 2016-09-23 | A kind of online ultraviolet detector of automated fluid |
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CN201610846030.3A CN106153543A (en) | 2016-09-23 | 2016-09-23 | A kind of online ultraviolet detector of automated fluid |
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Family
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10267851A (en) * | 1997-03-27 | 1998-10-09 | Mitsui Chem Inc | Method and apparatus for measuring online concentration of chlorine gas in gas produced from reaction |
US20030053050A1 (en) * | 2001-08-24 | 2003-03-20 | Potyrailo Radislav Alexandrovich | Method and apparatus for in situ determination of molten polycarbonate composition using electronic absorption spectroscopy |
CN101241072A (en) * | 2007-02-09 | 2008-08-13 | 北京中医药大学 | Medicament ingredient on-line detection method in pharmacy procedure and on-line detection system |
CN101614659A (en) * | 2009-07-24 | 2009-12-30 | 上海现代中医药技术发展有限公司 | The Chinese medicine leaching process is carried out the apparatus and method of online detection and control |
CN101825641A (en) * | 2010-04-22 | 2010-09-08 | 马三剑 | Water quality total nitrogen on-line automatic monitoring device |
CN101922969A (en) * | 2010-08-30 | 2010-12-22 | 南通北极光自动控制技术有限公司 | Diffuse reflection spectrum analyzer of ultraviolet, visible and near-infrared on-line detection |
CN103411910A (en) * | 2013-08-13 | 2013-11-27 | 杭州派析光电科技有限公司 | On-line ultraviolet spectrum detection method and system for traditional Chinese medicine extraction process |
CN206057164U (en) * | 2016-09-23 | 2017-03-29 | 天津中医药大学 | A kind of online ultraviolet detector of automated fluid |
-
2016
- 2016-09-23 CN CN201610846030.3A patent/CN106153543A/en active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10267851A (en) * | 1997-03-27 | 1998-10-09 | Mitsui Chem Inc | Method and apparatus for measuring online concentration of chlorine gas in gas produced from reaction |
US20030053050A1 (en) * | 2001-08-24 | 2003-03-20 | Potyrailo Radislav Alexandrovich | Method and apparatus for in situ determination of molten polycarbonate composition using electronic absorption spectroscopy |
CN101241072A (en) * | 2007-02-09 | 2008-08-13 | 北京中医药大学 | Medicament ingredient on-line detection method in pharmacy procedure and on-line detection system |
CN101614659A (en) * | 2009-07-24 | 2009-12-30 | 上海现代中医药技术发展有限公司 | The Chinese medicine leaching process is carried out the apparatus and method of online detection and control |
CN101825641A (en) * | 2010-04-22 | 2010-09-08 | 马三剑 | Water quality total nitrogen on-line automatic monitoring device |
CN101922969A (en) * | 2010-08-30 | 2010-12-22 | 南通北极光自动控制技术有限公司 | Diffuse reflection spectrum analyzer of ultraviolet, visible and near-infrared on-line detection |
CN103411910A (en) * | 2013-08-13 | 2013-11-27 | 杭州派析光电科技有限公司 | On-line ultraviolet spectrum detection method and system for traditional Chinese medicine extraction process |
CN206057164U (en) * | 2016-09-23 | 2017-03-29 | 天津中医药大学 | A kind of online ultraviolet detector of automated fluid |
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Application publication date: 20161123 |