CN106138530A - 一种外科用皮肤麻醉膏 - Google Patents

一种外科用皮肤麻醉膏 Download PDF

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CN106138530A
CN106138530A CN201610611476.8A CN201610611476A CN106138530A CN 106138530 A CN106138530 A CN 106138530A CN 201610611476 A CN201610611476 A CN 201610611476A CN 106138530 A CN106138530 A CN 106138530A
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李秀军
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Abstract

本发明公开了一种外科用皮肤麻醉膏，包括以下重量份数的原料：丙胺卡因0.1‑0.5份、盐酸利多卡因0.1‑0.5份、盐酸达克罗宁0.5‑1份、羊踯躅7‑15份、荣莉花根2‑5份、当归15‑20份、菖蒲3‑8份、曼陀罗2‑3份、薄荷4‑8份、咪唑烷基脲0.1‑0.4份、聚乙二醇2‑5份、丙二醇6‑10份。本发明采用中西药结合的方式制备麻醉膏，西药含量较少，对身体副作用小，通过加入中药增大药效，麻醉效果显著，持续时间长。

Description

一种外科用皮肤麻醉膏
技术领域
本发明属于医药制剂领域，具体涉及一种外科用皮肤麻醉膏。
背景技术
皮肤麻醉膏在临床外科上的使用非常广泛目前临床上的皮肤麻醉成分以利多卡因为主，利多卡因局部麻醉效果好，穿透力强，但毒性大，一般用量在2-4%左右，用量太小麻醉效果不好，持续时间短。利多卡因酰胺键稳定，对酸或碱性溶液均不易水解，体内酶解的速度也比较慢，利多卡因在体内大部分由肝脏代谢，因此对身体损伤大。盐酸达克罗宁作用较持久，毒性比利多卡因小，刺激性较大。
发明内容
为弥补现有技术的不足，本发明提供一种使用效果好，毒性小的外科用皮肤麻醉膏。
本发明是通过如下技术方案实现的：
一种外科用皮肤麻醉膏，其特殊之处在于：包括以下重量份数的原料：丙胺卡因0.1-0.5份、盐酸利多卡因0.1-0.5份、盐酸达克罗宁0.5-1份、羊踯躅7-15份、荣莉花根2-5份、当归15-20份、菖蒲3-8份、曼陀罗2-3份、薄荷4-8份、咪唑烷基脲0.1-0.4份、聚乙二醇2-5份、丙二醇6-10份。
本发明的外科用皮肤麻醉膏，优选方案为：包括以下重量份数的原料：丙胺卡因0.5份、盐酸利多卡因0.5份、盐酸达克罗宁0.8份、羊踯躅9份、荣莉花根3份、当归20份、菖蒲6份、曼陀罗2份、薄荷7份、咪唑烷基脲0.3份、聚乙二醇4份、丙二醇10份。
本发明的外科用皮肤麻醉膏的制备方法，其特征在于：包括以下步骤：将羊踯躅、荣莉花根、当归、菖蒲、曼陀罗、薄荷洗净，加其重8-10倍的水在75-90℃煎煮两次，每次20-30min，冷却合并煎液并过滤，将煎液加热至50-55℃加入丙胺卡因、盐酸利多卡因、盐酸达克罗宁和丙二醇，搅拌使其全部溶解，再加入聚乙二醇继续搅拌20-30min，冷却后加入咪唑烷基脲，搅拌均匀。
本发明的有益效果是：本发明的皮肤麻醉膏采用中西药结合的方式，少量西药麻醉成分不会造成对肝脏代谢的负担，中药成分本身具有透皮麻醉作用，对身体危害小，与西药结合后起到协同增效作用，效果显著，持续时间长。
具体实施方式
实施例1
本实施例的外科用皮肤麻醉膏，包括以下原料：丙胺卡因0.1g、盐酸利多卡因0.1 g、盐酸达克罗宁0.5g、羊踯躅7g、荣莉花根2g、当归15 g、菖蒲3 g、曼陀罗2 g、薄荷4g、咪唑烷基脲0.1 g、聚乙二醇2 g、丙二醇6 g。
将羊踯躅、荣莉花根、当归、菖蒲、曼陀罗、薄荷洗净，加其重8倍的水在75℃煎煮两次，每次30min，冷却合并煎液并过滤，将煎液加热至50℃加入丙胺卡因、盐酸利多卡因、盐酸达克罗宁和丙二醇，搅拌使其全部溶解，再加入聚乙二醇继续搅拌20min，冷却后加入咪唑烷基脲，搅拌均匀。
实施例2
本实施例的外科用皮肤麻醉膏，包括以下原料：丙胺卡因0.5 g、盐酸利多卡因0.5 g、盐酸达克罗宁0.8 g、羊踯躅9 g、荣莉花根3 g、当归20 g、菖蒲6 g、曼陀罗2 g、薄荷7 g、咪唑烷基脲0.3 g、聚乙二醇4 g、丙二醇10 g。
将羊踯躅、荣莉花根、当归、菖蒲、曼陀罗、薄荷洗净，加其重9倍的水在85℃煎煮两次，每次20min，冷却合并煎液并过滤，将煎液加热至55℃加入丙胺卡因、盐酸利多卡因、盐酸达克罗宁和丙二醇，搅拌使其全部溶解，再加入聚乙二醇继续搅拌25min，冷却后加入咪唑烷基脲，搅拌均匀。
实施例3
本实施例的外科用皮肤麻醉膏，包括以下原料：丙胺卡因0.5g、盐酸利多卡因0.5 g、盐酸达克罗宁1 g、羊踯躅15 g、荣莉花根5 g、当归20 g、菖蒲8 g、曼陀罗3 g、薄荷8 g、咪唑烷基脲0.4 g、聚乙二醇5 g、丙二醇10 g。
将羊踯躅、荣莉花根、当归、菖蒲、曼陀罗、薄荷洗净，加其重10倍的水在90℃煎煮两次，每次25min，冷却合并煎液并过滤，将煎液加热至53℃加入丙胺卡因、盐酸利多卡因、盐酸达克罗宁和丙二醇，搅拌使其全部溶解，再加入聚乙二醇继续搅拌30min，冷却后加入咪唑烷基脲，搅拌均匀。

Claims (3)

1.一种外科用皮肤麻醉膏，其特征在于：包括以下重量份数的原料：丙胺卡因0.1-0.5份、盐酸利多卡因0.1-0.5份、盐酸达克罗宁0.5-1份、羊踯躅7-15份、荣莉花根2-5份、当归15-20份、菖蒲3-8份、曼陀罗2-3份、薄荷4-8份、咪唑烷基脲0.1-0.4份、聚乙二醇2-5份、丙二醇6-10份。
2.根据权利要求1所述的一种外科用皮肤麻醉膏，其特征在于：包括以下重量份数的原料：丙胺卡因0.5份、盐酸利多卡因0.5份、盐酸达克罗宁0.8份、羊踯躅9份、荣莉花根3份、当归20份、菖蒲6份、曼陀罗2份、薄荷7份、咪唑烷基脲0.3份、聚乙二醇4份、丙二醇10份。
3.根据权利要求1或2所述的一种外科用皮肤麻醉膏的制备方法，其特征在于：包括以下步骤：将羊踯躅、荣莉花根、当归、菖蒲、曼陀罗、薄荷洗净，加其重8-10倍的水在75-90℃煎煮两次，每次20-30min，冷却合并煎液并过滤，将煎液加热至50-55℃加入丙胺卡因、盐酸利多卡因、盐酸达克罗宁和丙二醇，搅拌使其全部溶解，再加入聚乙二醇继续搅拌20-30min，冷却后加入咪唑烷基脲，搅拌均匀。
CN201610611476.8A 2016-07-30 2016-07-30 一种外科用皮肤麻醉膏 Pending CN106138530A (zh)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1385153A (zh) * 2001-05-11 2002-12-18 张国智 表面麻醉膏的配制方法
CN103877252A (zh) * 2014-03-25 2014-06-25 王寿世 一种用于局部麻醉的复合药剂及其制备方法
CN104800396A (zh) * 2015-04-29 2015-07-29 张如意 一种麻醉剂及其制备方法和使用方法
CN105267516A (zh) * 2015-09-24 2016-01-27 赵钦征 一种用于皮肤表层局部麻醉的膏药

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1385153A (zh) * 2001-05-11 2002-12-18 张国智 表面麻醉膏的配制方法
CN103877252A (zh) * 2014-03-25 2014-06-25 王寿世 一种用于局部麻醉的复合药剂及其制备方法
CN104800396A (zh) * 2015-04-29 2015-07-29 张如意 一种麻醉剂及其制备方法和使用方法
CN105267516A (zh) * 2015-09-24 2016-01-27 赵钦征 一种用于皮肤表层局部麻醉的膏药

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
卢旭东: "《三国笔记》", 30 November 2009 *

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