CN106137840A - A kind of ginseng extracting method and facial mask - Google Patents

A kind of ginseng extracting method and facial mask Download PDF

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Publication number
CN106137840A
CN106137840A CN201610620372.3A CN201610620372A CN106137840A CN 106137840 A CN106137840 A CN 106137840A CN 201610620372 A CN201610620372 A CN 201610620372A CN 106137840 A CN106137840 A CN 106137840A
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China
Prior art keywords
cylinder
ginseng
concentrate
swingle
facial mask
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CN201610620372.3A
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Chinese (zh)
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卞毓平
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Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
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Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
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Priority to CN201610620372.3A priority Critical patent/CN106137840A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/0011—Heating features
    • B01D1/0017—Use of electrical or wave energy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/30—Accessories for evaporators ; Constructional details thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/402—Mixers using gas or liquid agitation, e.g. with air supply tubes comprising supplementary stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/406—Mixers using gas or liquid agitation, e.g. with air supply tubes in receptacles with gas supply only at the bottom
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/10—Temperature; Pressure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B23/00—Heating arrangements
    • F26B23/04—Heating arrangements using electric heating
    • F26B23/06—Heating arrangements using electric heating resistance heating
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

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Abstract

The present invention provides a kind of ginseng extracting method, and preparation method is: take fresh ginseng, cleans after rubbing, adding ethanol makes the percent by volume of alcohol content reach 75%, stirs, stands 24 hours, filtering, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtain concentrate, use supercritical extract, obtain supercritical extract, continue to concentrate, concentrate is dried, is prepared as ginseng extract, prepare content of ginsenoside high, and be prepared as facial mask with cimicifugoside and curculigoside compatibility.

Description

A kind of ginseng extracting method and facial mask
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, be specifically related to a kind of ginseng extracting method and facial mask.
Background technology
Ginseng extracting method in prior art, technique is coarse, backward, and impurity is many, and active constituent content is low, causes patient to use Measure excessive, it has not been convenient to take, had a strong impact on this product and applied clinically.
Content of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of ginseng extracting method and facial mask.
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of ginseng extracting method, preparation method is: take fresh ginseng, cleans after rubbing, and adding ethanol makes the body of alcohol content Long-pending percentage reaches 75%, stirs, stands 24 hours, filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims second Alcohol, obtains concentrate, uses supercritical extract, obtains supercritical extract, continues to concentrate, is dried concentrate, preparation adult Conopsea extraction.
Concentrate is joined CO in preparation method by described ginseng extracting method2In supercritical extract device, ethanol is as folder Band agent, the percent by volume that entrainer accounts for total extractant is 4-6%, extracting pressure 15-30MPa, temperature 30-50 DEG C, CO2Stream Amount 1-3m1/g crude drug min, extraction time 150-180min, obtain supercritical extract, and optimum condition is: described CO2Overcritical The percent by volume that extraction entrainer accounts for total extractant is 5%, described CO2Extracting pressure 20MPa of supercritical extract, temperature 40 DEG C, CO2Flow 2ml/g crude drug min, extraction time 160min.
Described ginseng extracting method, concentrates in said extracted method and uses device, including concentrate cylinder, be arranged on described dense The evaporimeter of contracting cylinder body bottom, is provided with venthole at the top of described concentration cylinder and condenses panel, in described condensation panel It is provided with cooling liquid storage chamber, be provided with the feed tube being connected with described cooling liquid storage chamber and row at the top of described concentration cylinder Go out pipe, it is characterised in that: the roof in described concentration cylinder is provided with the swingle downwardly extending, and described swingle is provided with to be scraped Dirt cutterhead, the web of described scraper dish contacts with the inwall concentrating cylinder, is provided with liter on the roof of described concentration cylinder Sending down abnormally ascending cylinder, the top of described swingle passes through the roof of described concentration cylinder and top is connected with described lift cylinder, in institute Being provided with electric rotating machine in stating swingle, the main shaft of described electric rotating machine is connected with the center of described scraper dish, described dense The top of contracting cylinder is additionally provided with the elevating lever through roof, is provided with in the bottom of described elevating lever and horn-like inhales bubble mouth, described It is provided with in elevating lever and steeps, with described horn-like suction, the suction bubble passage that mouth is connected, be provided with adsorption pump at the top of described elevating lever Body, is provided with regulation cylinder between the roof and described elevating lever of described concentration cylinder, and described elevating lever is at described regulation cylinder Effect under described concentration cylinder in do lifting moving.
Described ginseng extracting method, the sidewall concentrating cylinder in said extracted method described in enrichment facility is provided with observation Window, is provided with seal glass in described observation window, and described scraper dish is circular, the external diameter of described scraper dish and concentration cylinder Identical and scraper dish the inner ring surface of the internal diameter of body is connected with the main shaft of electric rotating machine by dowel bar, and described evaporimeter is Columnar structured, described evaporimeter is connected to concentrate the diapire of cylinder by adpting flange, is provided with evaporation in described evaporimeter Pipe, is provided with the steam inlet being connected with described evaporation tube and steam (vapor) outlet on the sidewall of described evaporimeter.
Described ginseng extracting method, is dried in said extracted method and uses device, including hothouse and described hothouse phase The air quantity regulation room of connection, is provided with charging aperture on the roof of described hothouse, is provided with discharging opening in the bottom of described hothouse, Described air quantity regulation room is provided with air intake passage, described hothouse is provided with air exhaust passage, it is characterised in that: at described wind It is provided with dividing plate between amount regulation room and described hothouse, described dividing plate is uniformly provided with pore, described dividing plate is additionally provided with The cavity of lateral opening, described cavity is arranged on the side by hothouse, is provided with electric rotating machine in described cavity, be additionally provided with The swingle that described electric rotating machine main shaft is connected, is provided with upset paddle on the surface of described swingle, and described swingle is stretched Enter in described hothouse, be provided with air guide channel at the center of described swingle, described upset paddle is uniformly provided with and institute Stating the hot gas injection jets that air guide channel is connected, when described wind is stretched in the end of described swingle, regulation indoor, lead in described air guide It is provided with heat conduction blower fan in road, regulate indoor when described wind and be provided with movable plate, be provided with and described gas in the side of described movable plate The air quantity adjusting plug that matches in hole and the air holes being arranged between adjacent air quantity adjusting plug, adjust with described air quantity at described movable plate It is provided with mobile regulation cylinder between the sidewall of joint room.
Described ginseng extracting method, is dried in said extracted method and uses the roof of described air quantity regulation room described in device to set Having chute, the diapire in described air quantity regulation room is provided with shifting chute, and described shifting chute is consistent with the trend of described chute, described shifting The top of dynamic plate is movably arranged in described chute by scroll wheel, and the bottom of described movable plate is movably arranged on by movable block In described shifting chute, described mobile regulation cylinder is arranged between described movable block and the end wall of shifting chute.
Described ginseng extracting method, in said extracted method, the dry main shaft using electric rotating machine described in device is provided with and drives Active toothed disk, is provided with the teeth groove mutually ratcheting with described driving fluted disc on described swingle, and the opening part of described cavity is provided with protection Net, described swingle passes through described protection network and arranges.
Facial mask, the ginseng extract being prepared by said method, cimicifugoside, curculigoside form, and prepare according to a conventional method Become facial mask.
Described facial mask, ginseng extract, cimicifugoside, the weight of curculigoside, than for 8-12:4-6:5-7, are made according to a conventional method Standby one-tenth facial mask.
Described facial mask, ginseng extract, cimicifugoside, the weight of curculigoside, than for 10:5:6, are prepared as face according to a conventional method Film.
In prior art, the original extracting method of ginseng, technique is coarse, backward, and impurity is many, causes patient's consumption excessive, no Conveniently taking, content of ginsenoside prepared by the present invention increases, and content is high.Concentrator simple in construction in the present invention, operation Convenient, it not only can start scraper dish as required and do lift adjustment as required such that it is able to realize to concentration cylinder Inwall carry out scraping dirt process, the descending operation that simultaneously can also regulate elevating lever as required makes horn-like bubble mouth of inhaling be in medicine Being absorbed the foam on surface by the absorption pump housing just above of thing liquid level, solves tube wall medicine in conventional art medicine enrichment facility Dirt removes the technical deficiency of difficulty, and stability in use is good and applicability is strong.This drying equipment structure is simple, simple operation, is provided with Overturn paddle and in upset paddle, be provided with the hot gas injection jets being connected with air quantity regulation room, making while stirring medicinal material Medicinal material is dried, adds the speed contacting with medicinal material, can effectively improve medicinal material drying efficiency, and stability in use Good, solve the low technical deficiency of conventional art pharmaceutical drying device drying efficiency, applicability is strong and practicality good.
Brief description
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiment and combine accompanying drawing, right The present invention is described in further detail, wherein:
Fig. 1 is the structural representation of enrichment facility of the present invention.
Fig. 2 is the structural representation of drying device of the present invention.
Detailed description of the invention
Form by the following examples, is described in further detail to the foregoing of the present invention again, but should be by this Being interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology being realized based on foregoing of the present invention are equal Belong to the scope of the present invention.
Embodiment 1
Taking fresh ginseng 1000g, cleaning after rubbing, adding ethanol makes the percent by volume of alcohol content reach 75%, stirs, stands 24 hours, filtering, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrate, uses overcritical extraction Take, obtain supercritical extract, continue to concentrate, concentrate is dried, is prepared as ginseng extract.
Described supercritical extraction method is: join concentrate in CO2 supercritical extract device, ethanol as entrainer, The percent by volume that entrainer accounts for total extractant is 4%, extracting pressure 30MPa, temperature 30 DEG C, CO2 flow 3m1/g crude drug Min, extraction time 150min, obtain supercritical extract.
Seeing Fig. 1: described ginseng extracting method, above-mentioned concentration uses device, including concentrate cylinder 1, is arranged on described concentration Evaporimeter 2 bottom cylinder 1, is provided with venthole 3 at the top of described concentration cylinder 1 and condenses panel 4, at described condensation panel It is provided with cooling liquid storage chamber 5 in 4, be provided with the feed liquor being connected with described cooling liquid storage chamber 5 at the top of described concentration cylinder 1 Pipe 6 and discharge pipe 7, be provided with condensation panel, the gas partial coagulation of medicine evaporation at night can be become moisture, be possible to prevent drug volatilization Falling, the roof in described concentration cylinder 1 is provided with the swingle 8 downwardly extending, and described swingle 8 is provided with scraper dish 9, institute The web stating scraper dish 9 contacts with the inwall of concentration cylinder 1, is provided with lift cylinder on the roof of described concentration cylinder 1 10, the top of described swingle 8 passes through the roof of described concentration cylinder 1 and top is connected with described lift cylinder 10, in institute Being provided with electric rotating machine 11 in stating swingle 8, the main shaft of described electric rotating machine 11 is connected with the center of described scraper dish 9, The top of described concentration cylinder 1 is additionally provided with the elevating lever 12 through roof, is provided with horn-like suction in the bottom of described elevating lever 12 Bubble mouth 13, is provided with in described elevating lever 12 and steeps, with described horn-like suction, the suction bubble passage 14 that mouth 13 is connected, in described lifting The top of bar 12 is provided with the absorption pump housing 15, is provided with regulation cylinder between the roof and described elevating lever 12 of described concentration cylinder 1 16, described elevating lever does lifting moving under the effect of described regulation cylinder in described concentration cylinder.
The sidewall of described concentration cylinder 1 is provided with observation window 17, in described observation window, is provided with seal glass 18.
Described scraper dish is circular, the external diameter of described scraper dish with concentrate cylinder internal diameter is identical and scraper dish Inner ring surface be connected with the main shaft of electric rotating machine by dowel bar.It is not to carry out owing to scraping dirt and inhaling bubble simultaneously, so Both can't cause mutually restriction.
Described evaporimeter 2 is columnar structured, and described evaporimeter 2 is connected to concentrate the end of cylinder 1 by adpting flange 19 Wall, is provided with evaporation tube 20 in described evaporimeter, is provided with and is connected with described evaporation tube 20 on the sidewall of described evaporimeter 2 Steam inlet 21 and steam (vapor) outlet 22.
Seeing Fig. 2: described ginseng extracting method, above-mentioned drying uses device, including include hothouse 1 and described hothouse 1 The air quantity regulation room 2 being connected, is provided with charging aperture 3 on the roof of described hothouse 1, is provided with in the bottom of described hothouse 1 Discharging opening 4, is provided with air intake passage 5 on described air quantity regulation room 2, is provided with air exhaust passage 6, described on described hothouse 1 It is provided with dividing plate 7 between air quantity regulation room 2 and described hothouse 1, described dividing plate 7 is uniformly provided with pore 8, at described dividing plate 7 On be additionally provided with the cavity 9 of lateral opening, described cavity 9 is arranged on the side by hothouse 1, is provided with rotation in described cavity 9 Motor 10, is additionally provided with the swingle 11 being connected with described electric rotating machine 10 main shaft, is provided with on the surface of described swingle 11 and turns over Turning paddle 12, described swingle 11 stretches in described hothouse 1, is provided with air guide channel 13 at the center of described swingle 11, Described upset paddle 12 is uniformly provided with the hot gas injection jets 14 being connected with described air guide channel 13, described swingle 11 It when described wind is stretched in end in regulation room 2, in described air guide channel 13, is provided with heat conduction blower fan 15, regulate room 2 when described wind It is inside provided with movable plate 16, be provided with the air quantity adjusting plug 17 matching with described pore 8 in the side of described movable plate 16 and arrange Air holes 18 between adjacent air quantity adjusting plug, regulates at described movable plate 16 and described air quantity and is provided with shifting between the sidewall of room 2 Dynamic regulation cylinder 19.
Roof in described air quantity regulation room 2 is provided with chute 20, and the diapire in described air quantity regulation room 2 is provided with shifting chute 21, described shifting chute 21 is consistent with the trend of described chute 20, and the top of described movable plate 16 is arranged by scroll wheel 22 activity In described chute 20, the bottom of described movable plate 16 is movably arranged in described shifting chute 21 by movable block 23, described shifting Dynamic regulation cylinder 19 is arranged between described movable block 23 and the end wall of shifting chute 21.
The main shaft of described electric rotating machine is provided with driving fluted disc 24, described swingle is provided with and described driving fluted disc Mutually ratcheting teeth groove 25.
Opening part at described cavity is provided with protection network 26, and described swingle passes through described protection network and arranges.
Take the weight of ginseng extract, cimicifugoside, curculigoside prepared by said method than for 10:5:6, make according to a conventional method Standby one-tenth facial mask.
Embodiment 2
Taking fresh ginseng 1000g, cleaning after rubbing, adding ethanol makes the percent by volume of alcohol content reach 75%, stirs, stands 24 hours, filtering, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrate, uses overcritical extraction Take, obtain supercritical extract, continue to concentrate, concentrate is dried, is prepared as ginseng extract.
Described supercritical extraction method is: join concentrate in CO2 supercritical extract device, ethanol as entrainer, The percent by volume that entrainer accounts for total extractant is 6%, extracting pressure 15MPa, temperature 50 C, CO2 flow 1m1/g crude drug Min, extraction time 180min, obtain supercritical extract.
Concentrate with drying equipment ibid.
Take the weight of ginseng extract, cimicifugoside, curculigoside prepared by said method than for 10:4:7, make according to a conventional method Standby one-tenth facial mask.
Embodiment 3
Taking fresh ginseng 1000g, cleaning after rubbing, adding ethanol makes the percent by volume of alcohol content reach 75%, stirs, stands 24 hours, filtering, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrate, uses overcritical extraction Take, obtain supercritical extract, continue to concentrate, concentrate is dried, is prepared as ginseng extract.
Described supercritical extraction method is: join concentrate in CO2 supercritical extract device, ethanol as entrainer, The percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 20MPa of described CO2 supercritical extract, temperature 40 DEG C, CO2 flow 2ml/g crude drug min, extraction time 160min, obtain supercritical extract.
Concentrate with drying equipment ibid.
Take the weight of ginseng extract, cimicifugoside, curculigoside prepared by said method than for 10:6:5, make according to a conventional method Standby one-tenth facial mask.
In above-described embodiment, cimicifugoside (30%), curculigoside (70%) are purchased from bio tech ltd of AOC, Shaanxi.
Embodiment 4: by method preparation in embodiment 1 without the facial mask of cimicifugoside.
Embodiment 5: by method preparation in embodiment 1 without the facial mask of curculigoside.
Measuring content of ginsenoside experimental study data in embodiment 6 ginseng of the present invention extracting method
1.1 Experimental agents: facial mask of the present invention: prepare by embodiment 1-3 method.Control group is for using general according to embodiment 1 Logical concentration is prepared as facial mask with drying means.
1.2 instruments: high performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pump； Waters2487 UV-detector and GJ605 type high pressure six-way injection valve；Data acquisition and process use the work of HS chromatographic data Stand V4.0+ (Hangzhou English spectrum science and technology).
1.3 condition determinations: measure according to high performance liquid chromatography (general rule 0512).Chromatographic condition and system suitability: Chromatographic column is MUCLEODUR C18,4.6 × 250mm, 5 μm, column temperature 35 DEG C；With methanol-water (60:40) for flowing phase；Detection ripple A length of 250nm；Number of theoretical plate is calculated by general ginsenoside peak should be not less than 2000.Take general ginsenoside reference substance appropriate, accurate Weighed, add methyl alcohol and make the solution containing 5ug for every lm l, to obtain final product.The preparation of need testing solution takes this product under content uniformity item, grinds Carefully, about 0.5g is taken, accurately weighed, put in 25ml measuring bottle, add methyl alcohol 20ml, ultrasonically treated (power 250W, frequency 40kHz) 30 points Clock, lets cool, and adds methyl alcohol to scale, shakes up, and filters, takes subsequent filtrate, to obtain final product.Precision absorption reference substance solution is molten with test sample respectively The each 20ul of liquid injects liquid chromatograph, measures, to obtain final product.
1.4 experimental result
Total Ginsenosides Content measurement result in facial mask prepared by each embodiment
Sample source Total Ginsenosides Content (%)
Embodiment 1 0.56
Embodiment 2 0.61
Embodiment 3 0.59
Control group 0.14
According to the result of the test of upper table, in facial mask prepared by embodiment of the present invention 1-3, total Ginsenosides Content is obvious Higher than control group.
Embodiment 7: the impact on cleaning test, gentle excitant test:
Test method: the test of described cleaning is: will preparation embodiment the 1st, the 4th, 5, be respectively issued to 50 testers and use.Survey Being carried out in the same manner during examination librarian use sample, every kind of sample uses 2 weeks.Tester is according to the sensation of oneself Mark.Standards of grading take ten point system, and 1 point worst, and 10 points best.
The concrete clean method of tester is: after first using clear water to drench skin, use product of the present invention in right amount in hand The heart, after rubbing out foam gently, applies and arm skin, and gently rubs arm skin one minute；Then rinsed well by clear water, repeat on State step, each sample determination 6 times.
Described gentle excitant test is: will prepare case study on implementation the 1st, the 4th, 5, is respectively issued to 50 testers and contrasts and make With.Every kind of sample uses 2 weeks, tester according to oneself feel appraise through comparison.Content on probation includes: has or not excitement, have Have or not general red without itch, arm skin.Standards of grading take ten point system, and 1 point worst, and 10 points best.
The concrete method of testing of tester is: after first using clear water to drench arm skin, use product of the present invention appropriate In the palm of the hand, after rubbing out foam gently, apply and arm skin, and gently rub arm skin one minute, then rinsed well by clear water, weight Multiple above-mentioned steps, each sample test six times.
Using effect evaluation table of the present invention
Sample source Skin comfort degree Bath skinfeel Clean up sense Moisturizing effect after dry Foaming abundancy sense
Embodiment 1 9.7 9.5 9.6 9.3 9.5
Embodiment 4 7.3 6.4 5.5 5.2 6.5
Embodiment 5 6.6 7.9 7.5 7.3 7.1
Show: embodiment 1 skin comfort degree, bath skinfeel, to clean up sense, dry moisturizing effect, foaming abundancy sense afterwards bright Aobvious being better than embodiment the 4th, 5, after illustrate that ginseng extract, cimicifugoside, curculigoside compound, having gentle non-stimulated effect, ratio is individually Use one of which or several raw material effect more preferable.
Embodiment 8: the clinical research to acne
Physical data: acne are mainly in face, sometimes can extrude white with papule, warts, tubercle and crack rice sample powder juice as spy A kind of skin disease levied.Be equivalent to acne vulgaris.Inventor collects 50 case acne between in November ,-2013 in June, 2012 altogether Out-patient, the male sex 38 people, women 12 people, age 16-23 year, be randomly divided into: treatment group 30 case, blank group 20 cases.Two groups There was no significant difference for the data such as age, sex, the state of an illness, has comparativity.
Diagnostic criteria: from the beginning of at follicular orifice, present small rice grain size red papules, also can develop into warts.Hereafter can shape Becoming scleroma sample Whiteheads or blackhead, several cases can form scleroma property tumour.The face that is mainly in men and women puberty and Chest and back, is often accompanied by seborrhea.Having eating and drinking without temperance, overfeeding delicious food savoury is, or feel the inductions such as outer heresy more.After puberty, many Number can mitigate naturally.Women is many with irregular menstruation.
Syndrome-classification: wind and heat in the lung meridian: papule look red, or have pain of itching.Tongue is red, the thin Huang of tongue, superficial and rapid pulse.Damp-heat accumulation: fash Congestion and swelling pain, or have warts, halitosis, constipation, urine Huang.Tongue is red, yellow and greasy fur, slippery and rapid pulse.The wet condensation of phlegm: fash forms tumour, or Have indigestion and loss of appetite, loose stool.Tongue is light fat, and tongue is thin, and arteries and veins is sliding.
Test method: taking the present invention outside treatment group according to specific embodiment the 1st, the 4th, 5 facial mask preparing, the morning, noon and afternoon paste one respectively Secondary, apply ointment or plaster on the face 30 minutes every time, 15 days courses for the treatment of.The blank group patch new seven white whitening and softening skin facial masks of herborist, the morning, noon and afternoon are respectively Patch once, is applied ointment or plaster on the face 30 minutes, 15 days courses for the treatment of every time.
Criterion of therapeutical effect and treatment results: criterion of therapeutical effect: recovery from illness: skin lesion is disappeared, subjective symptoms disappears.Take a turn for the better: feel Symptom substantially mitigates, and skin damages and disappears more than 30%.Invalid: it is all unchanged or disappear less than 30% that skin undermines symptom.
Comparitive study
Group n Recovery from illness Take a turn for the better Invalid Total effective rate (%)
Embodiment 1 30 12 14 4 86.6
Embodiment 4 30 7 6 17 43.3
Embodiment 5 30 5 7 18 40
Blank group 20 1 1 18 10
Visible, acne can safely and effectively be treated by the facial mask that the embodiment of the present invention 1 prepares, and are significantly better than embodiment the 4th, 5。

Claims (10)

1. a ginseng extracting method, it is characterised in that preparation method is: take fresh ginseng, cleans after rubbing, and adding ethanol makes to contain The percent by volume of alcohol amount reaches 75%, stirs, stands 24 hours, filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and Reclaim ethanol, obtain concentrate, use supercritical extract, obtain supercritical extract, continue to concentrate, concentrate is dried, system Standby one-tenth ginseng extract.
2. ginseng extracting method according to claim 1, it is characterised in that in preparation method, concentrate is joined CO2Surpass and face In boundary's extractor, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 4-6%, extracting pressure 15- 30MPa, temperature 30-50 DEG C, CO2Flow 1-3m1/g crude drug min, extraction time 150-180min, obtain supercritical extract, Optimum condition is: described CO2The percent by volume that supercritical extract entrainer accounts for total extractant is 5%, described CO2Overcritical Extracting pressure 20MPa of extraction, temperature 40 DEG C, CO2Flow 2ml/g crude drug min, extraction time 160min.
3. ginseng extracting method according to claim 1, it is characterised in that concentrate in said extracted method and use device, including Concentrate cylinder, be arranged on the evaporimeter of described concentration cylinder body bottom, be provided with venthole and condensation at the top of described concentration cylinder Panel, is provided with cooling liquid storage chamber in described condensation panel, is provided with at the top of described concentration cylinder and deposits with described cooling liquid Feed tube that storage chamber is connected and discharge pipe, it is characterised in that: the roof in described concentration cylinder is provided with the rotation downwardly extending Bull stick, described swingle is provided with scraper dish, and the web of described scraper dish contacts with the inwall concentrating cylinder, described The roof concentrating cylinder is provided with lift cylinder, and the top of described swingle passes through the described roof concentrating cylinder and top and institute State lift cylinder to be connected, in described swingle, be provided with electric rotating machine, the main shaft of described electric rotating machine and described scraper dish Center be connected, described concentration cylinder top be additionally provided with the elevating lever through roof, set in the bottom of described elevating lever There is horn-like suction to steep mouth, be provided with in described elevating lever and steep, with described horn-like suction, the suction bubble passage that mouth is connected, at described liter The top of fall bar is provided with the absorption pump housing, is provided with regulation cylinder between the roof and described elevating lever of described concentration cylinder, described Elevating lever does lifting moving under the effect of described regulation cylinder in described concentration cylinder.
4. ginseng extracting method according to claim 3, it is characterised in that concentrate described in enrichment facility in said extracted method The sidewall of cylinder is provided with observation window, is provided with seal glass in described observation window, and described scraper dish is circular, described scrapes Identical with the internal diameter of concentration cylinder and scraper dish the inner ring surface of the external diameter of dirt cutterhead passes through the master of dowel bar and electric rotating machine Axle is connected, and described evaporimeter is columnar structured, and described evaporimeter is connected to concentrate the diapire of cylinder by adpting flange, Be provided with evaporation tube in described evaporimeter, the sidewall of described evaporimeter is provided with the steam inlet being connected with described evaporation tube and Steam (vapor) outlet.
5. ginseng extracting method according to claim 1, it is characterised in that be dried in said extracted method and use device, including The air quantity regulation room that hothouse is connected with described hothouse, is provided with charging aperture on the roof of described hothouse, does described The bottom of dry room is provided with discharging opening, is provided with air intake passage, is provided with air draft and leads on described hothouse on described air quantity regulation room Road, it is characterised in that: it between described air quantity regulation room and described hothouse, is provided with dividing plate, described dividing plate is uniformly provided with gas Hole, is additionally provided with the cavity of lateral opening on described dividing plate, and described cavity is arranged on the side by hothouse, in described cavity It is provided with electric rotating machine, is additionally provided with the swingle being connected with described electric rotating machine main shaft, be provided with on the surface of described swingle and turn over Turning paddle, described swingle stretches in described hothouse, is provided with air guide channel at the center of described swingle, in described upset Being uniformly provided with the hot gas injection jets being connected with described air guide channel on paddle, the end of described swingle is adjusted when stretching into described wind Joint indoor, are provided with heat conduction blower fan in described air guide channel, regulate indoor when described wind and are provided with movable plate, at described movable plate The air quantity adjusting plug that side is provided with described pore matches and the air holes being arranged between adjacent air quantity adjusting plug, described It is provided with mobile regulation cylinder between the sidewall of movable plate and described air quantity regulation room.
6. ginseng extracting method according to claim 5, it is characterised in that be dried in said extracted method and use described in device The roof of described air quantity regulation room is provided with chute, and the diapire in described air quantity regulation room is provided with shifting chute, described shifting chute and institute The trend stating chute is consistent, and the top of described movable plate is movably arranged in described chute by scroll wheel, described movable plate Bottom is movably arranged in described shifting chute by movable block, and described mobile regulation cylinder is arranged on described movable block and shifting chute End wall between.
7. ginseng extracting method according to claim 5, it is characterised in that be dried in said extracted method and use described in device The main shaft of electric rotating machine is provided with driving fluted disc, is provided with the teeth groove mutually ratcheting with described driving fluted disc, institute on described swingle The opening part stating cavity is provided with protection network, and described swingle passes through described protection network and arranges.
8. a facial mask, it is characterised in that be made up of the ginseng extract preparing in claim 1, cimicifugoside, curculigoside, It is prepared as facial mask according to a conventional method.
9. facial mask according to claim 8, it is characterised in that ginseng extract, cimicifugoside, the weight of curculigoside are than for 8-12: 4-6:5-7, is prepared as facial mask according to a conventional method.
10. facial mask according to claim 9, it is characterised in that ginseng extract, cimicifugoside, the weight ratio of curculigoside are 10: 5:6, is prepared as facial mask according to a conventional method.
CN201610620372.3A 2016-07-30 2016-07-30 A kind of ginseng extracting method and facial mask Pending CN106137840A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1419905A (en) * 2001-11-16 2003-05-28 尚悦杰 Chinese medicine mask
CN1965875A (en) * 2006-11-17 2007-05-23 王玉良 Method for extracting ginseng essential oil and ginsenoside monomer by using sequential process
CN104825365A (en) * 2015-05-18 2015-08-12 樊文花 Ginseng skin whitening facial mask and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1419905A (en) * 2001-11-16 2003-05-28 尚悦杰 Chinese medicine mask
CN1965875A (en) * 2006-11-17 2007-05-23 王玉良 Method for extracting ginseng essential oil and ginsenoside monomer by using sequential process
CN104825365A (en) * 2015-05-18 2015-08-12 樊文花 Ginseng skin whitening facial mask and preparation method thereof

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