CN106132391B - Dispersive composition and cosmetics - Google Patents

Abstract

The present invention provides a kind of dispersive composition and the cosmetics containing dispersive composition, the surfactant and phosphatide containing sterol base which contains oryzanol, indicated with structural formula (1).In structural formula (1), EO indicates that Oxyranyle, PO indicate that propylene oxide base, BO indicate epoxy butane base；R indicates the sterol base in the group being made of phytosterol base, cholesteryl, phytostanyl base and cholesteric alkyl；L+m+n is 5 or more and 80 or less.R-O-(EO)_l‑(PO)_m‑(BO)_nH structure formula (1).

Description

Dispersive composition and cosmetics

Technical field

The present invention relates to a kind of dispersive composition and cosmetics.

Background technique

It 1954, is found from rice bran by gold and earth house and isolates oryzanol.By discovery oryzanol and from rice It is isolated in chaff, advances application of the oryzanol in medical supplies or food additives.

Known oryzanol has antioxidation identical with ferulic acid and the effect as natural ultraviolet absorbing agent Fruit.But had found that oryzanol had sebaceous glands activation effect in recent years, therefore to prevent from drying or prevent surface checking as mesh Have investigated in cosmetics allotment (for example, with reference to Japanese perfuming cosmetic association will, volume 81, p31-36 (1984 Year)).

However, since oryzanol is the ingredient for water and oil indissoluble, and crystallinity is high, therefore is very unstable to adjust It is assigned in the products such as cosmetics.

In order to realize the stable formulation of oryzanol, various researchs are carried out, such as propose by using specific Finish or dispersing agent, prevent oryzanol to be precipitated, and improve the emulsion stability of the dispersive composition containing oryzanol.

As the method steadily deployed oryzanol into cosmetics etc., in No. 231087 bulletins of Japanese Unexamined Patent Publication 2008- In, proposing ties up paddy using hydrogenated phospholipid, the aliphatic organic acid of carbon atom number 8~18 and the diester that is made of dihydric alcohol The stabilized method of element.Also, in Japanese Unexamined Patent Publication 2008-201753 bulletin and Japanese Unexamined Patent Publication 2012-821250 bulletin In, propose method oryzanol being dissolved in the glutamic acid acyl ester with cholesteryl and phytosterol base, in Japan In special open 2009-155326 bulletin, proposes using half solid~solid wax and nonionic surfactant and improve paddy dimension The method of the stability of element.

Summary of the invention

The invention technical task to be solved

However, in Japanese Unexamined Patent Publication 2008-231087 bulletin, Japanese Unexamined Patent Publication 2008-201753 bulletin, Japanese Unexamined Patent Publication In method documented by 2012-821250 bulletin and Japanese Unexamined Patent Publication 2009-155326 bulletin, in order to dissolve oryzanol, Need a large amount of finish.Therefore, the preparation technology of above-mentioned oryzanol recorded in the literature is being applied to toner and beauty Whens holding cosmetics such as liquid etc., makes the transparency decline of cosmetics etc. sometimes and use feeling is deteriorated due to sticky sense, be unable to fully Meet the quality of cosmetics obtained.

A kind of be able to suppress under transparency and use feeling when oryzanol is applied to cosmetics etc. is expected at present Drop, and dispersive composition that is steady in a long-term and containing oryzanol with high concentration.

Problem of the present invention is that being capable of providing a kind of includes the dispersed particle containing oryzanol and dispersion stabilization is excellent Dispersive composition, and provide a kind of cosmetics containing dispersive composition.

For solving the means of technical task

The inventors of the present invention have found after having made intensive studies in order to solve the above problems, by containing oryzanol, containing The surfactant and phosphatide of sterol base can obtain the dispersion containing the excellent oryzanol of dispersibility and dispersion stabilization Particle.These opinions according to the present invention and complete.

The present invention is as follows.

[1] a kind of dispersive composition, with oryzanol, the surface-active containing sterol base indicated with structural formula (1) Agent and phosphatide.

R-O-(EO)_l-(PO)_m-(BO)_n- H structural formula (1)

In structural formula (1), EO indicates that Oxyranyle, PO indicate that propylene oxide base, BO indicate epoxy butane base；R table Show the sterol base in the group being made of phytosterol base, cholesteryl, phytostanyl base and cholesteric alkyl；L+m+n is 5 Above and 80 or less.

[2] a kind of dispersive composition contains selected from by the compound that is indicated with structural formula (3) and with structural formula (4) At least one kind of compound A in group that the compound of expression is constituted, the surface-active containing sterol base indicated with structural formula (1) Agent and phosphatide.

[chemical formula 1]

In structural formula (3) and structural formula (4), R³And R⁴Separately indicate the straight-chain of carbon atom number 1~10 Or the straight-chain or alkenyl with branch, alkyl and alkenyl of the alkyl or carbon atom number 1~10 with branch It can have at least one substituent group in the group being made of the oxoalkyl group of carbon atom number 1~3 and OH base.

R-O-(EO)_l-(PO)_m-(BO)_n- H structural formula (1)

In structural formula (1), EO indicates that Oxyranyle, PO indicate that propylene oxide base, BO indicate epoxy butane base；R table Show the sterol base in the group being made of phytosterol base, cholesteryl, phytostanyl base and cholesteric alkyl；L+m+n is 5 Above and 80 or less.

[3] dispersive composition according to [2], wherein compound A includes selected from the change by being indicated with structural formula (5) Close object and with structural formula (6) expression the group being made of compound at least one kind of compound.

[chemical formula 2]

In structural formula (5), R⁵Indicate the 1 valence substituent group for being selected from structure as shown below.

[chemical formula 3]

[chemical formula 4]

In structural formula (6), R⁶Indicate the 1 valence substituent group for being selected from structure as shown below.

[chemical formula 5]

[4] dispersive composition according to any of [1] to [3], wherein contain steroid with what structural formula (1) indicated The surfactant of alcohol radical includes the surfactant containing sterol base indicated with structural formula (2).

R-O-(EO)_l- H structural formula (2)

In structural formula (2), EO indicates Oxyranyle；R is indicated selected from by phytosterol base, cholesteryl, plant steroid The sterol base in group that alkyl and cholesteric alkyl are constituted；L is 5 or more and 60 or less.

[5] dispersive composition according to any of [1] to [4], wherein phosphatide is lecithin.

[6] dispersive composition according to any of [1] to [5], it is small that the dispersive composition contains average grain diameter In the dispersed particle of 200nm.

[7] a kind of cosmetics contain dispersive composition described in any of [1] to [6].

[8] cosmetics according to [7], the turbidity of the cosmetics are 0.1 or less.

Invention effect

In accordance with the invention it is possible to provide a kind of containing the dispersed particle and dispersibility that include oryzanol and dispersion stabilization Excellent dispersive composition and the cosmetics containing dispersive composition.

Specific embodiment

Dispersive composition of the invention is containing oryzanol, the surface-active containing sterol base indicated with structural formula (1) The dispersive composition of agent (hreinafter referred to as " specific surfactant ") and phosphatide.

Dispersive composition of the invention contains specific surfactant and phosphatide, and thus oryzanol can be as small point Shot steadily exists.Therefore, dispersive composition of the invention is excellent as the dispersibility and dispersion stabilization of oryzanol Dispersive composition.In preferred mode of the invention, dispersive composition contain dispersed particle average grain diameter be 200nm with Under small dispersed particle.

Though effect of the invention is indefinite, following to consider.

Oryzanol contains the substance for carrying out ester bond knot there are many triterpene alcohol and ferulic acid and being formed.Contain in dispersive composition Specific surfactant be nonionic surfactant with sterol base as hydrophobic group, the steroid in specific surfactant Alcohol radical it is excellent with the compatibility of the multicyclic moeity structure of oryzanol.It can infer as follows: by using specific surfactant, The high oryzanol of crystallinity can be stably kept in dispersive composition, can make the dispersed particle containing oryzanol steadily Dispersion.Furthermore it is possible to think as follows: dispersive composition of the invention contains phosphatide, and thus the stability of dispersed particle more mentions Height, even if therefore dispersed particle containing oryzanol is small partial size, also become dispersibility and dispersion stabilization be excellent Dispersive composition.

However, any embodiment of the invention is not by any restrictions of above-mentioned deduction mechanism.

In the present specification with "~" indicate numberical range indicate will be recorded in "~" front and back numerical value respectively as The range that minimum value and maximum value include.

In addition, there is multiple be equivalent to respectively in the composition in the amount about each ingredient in composition in the present specification In the case where the substance of ingredient, unless otherwise specified, just refer to the total amount of multiple substance present in composition.

Hereinafter, embodiments of the present invention are described in more detail.

[oryzanol]

Be used in oryzanol in dispersive composition of the invention be 1954 by earth house etc. for the first time from rice bran oil and The powder separated is extracted in rice germ oil.Oryzanol is not single ingredient, but several triterpene alcohols and ferulic acid into Row ester bond knot and the mixture of compound formed.

As the oryzanol being used in the present invention, can enumerate from natural goodsOryzanol.In addition, of the invention Dispersive composition be able to use comprising selected from structural formula (3) indicate compound and with structural formula (4) expression chemical combination The oryzanol of the compound of the compound or synthesis from natural goods of a kind or more of object.

Hereinafter, the oryzanol that can be used in the present invention is described in detail.

The oryzanol being used in the present invention contains triterpene alcohol ferulic acid ester.

(triterpene alcohol ferulic acid ester)

The structure that there is triterpene alcohol ferulic acid ester ferulic acid to be formed with triterpene alcohol progress ester bond knot.With ferulic acid key The triterpene alcohol of knot exists a variety of.

As long as triterpene alcohol ferulic acid ester be with will be selected from the skeleton of triterpene skeleton and sterol backbone as with Ah Wei's acid carries out the alcohol position of ester bond knot, then can apply in the present invention.Furthermore it is possible to think as follows: due to being mentioned from plant It takes and mixed the different triterpene alcohol ferulic acid ester of multiple structures in the oryzanol obtained in object originally, therefore will be used as from plant In the case that the oryzanol of the extract of extraction is applied to cosmetics or functional food, containing with different triterpene alcohols A variety of triterpene alcohol ferulic acid esters at position.

Hereinafter, enumerating the generation for carrying out the triterpene alcohol compound of ester bond knot with ferulic acid in triterpene alcohol ferulic acid ester Table example.

[chemical formula 6]

(in the compound by being indicated with structural formula (3) and the group constituted with the compound that structural formula (4) indicate At least one kind of compound A)

As the representative compound for constituting oryzanol, for example, selected from by being indicated with following structural formula (3) Compound and with structural formula (4) indicate compound constitute group at least a kind of compound A.

[chemical formula 7]

In structural formula (3) and structural formula (4), R³And R⁴Separately indicate the straight-chain of carbon atom number 1~10 Or the straight-chain or alkenyl with branch, alkyl and alkenyl of the alkyl or carbon atom number 1~10 with branch It can have at least one substituent group in the group being made of the oxoalkyl group of carbon atom number 1~3 and OH base.

As compound A, preferably comprises selected from the compound by being indicated with structural formula (5) and indicated with structural formula (6) Compound constitute group at least one kind of compound.

[chemical formula 8]

In structural formula (5), R⁵Indicate the 1 valence substituent group for being selected from structure as shown below.

[chemical formula 9]

[chemical formula 10]

In structural formula (6), R⁶Indicate the 1 valence substituent group for being selected from structure as shown below.

[chemical formula 11]

As the concrete example of the representative compound contained in oryzanol, can enumerate to following representationsPaddy Sterol ferulate, 24-methylene cycloartanol ferulic acid ester, cycloartenyl ferulate, campesterol asafoetide Acid esters, ring cloth carry out alcohol ferulic acid ester etc., as the oryzanol or compound A in the present invention, can contain chemical combination illustrated below Object.

[chemical formula 12]

About the source for capableing of the oryzanol used in dispersive composition of the invention, there is no particular restriction.It can be at this Oryzanol used in the dispersive composition of invention for example can be to extract simultaneously from seed rice skin, rice bran oil and rice germ oil etc. The compound of purification and acquisition, or obtained containing extracting and purifying from seed rice skin, rice bran oil and rice germ oil etc. The mixture of the oryzanol obtained can also pass through the compound that synthesis obtains for all or part.

In the case where dispersive composition of the invention contains compound A, in dispersive composition of the invention, can make With from containing be contained in the compound A described compound oryzanol the extract of Nature inorganic bone or mentioning for purification The composite of the one kind or two or more compound for being contained in compound A also can be used in pure object.

Commercially available product also can be used in oryzanol.

As commercially available product, it is provided as mostlyOryzanol.As the representative commercially available product of oryzanol, can enumerate- Gu Wei Element (trade name: Tsuno Co., Ltd. manufacture),Oryzanol (trade name: Oryza Oil&Fat Chemical Co., Ltd. manufacture),24-methylenecycloartanyl ferulate, OK sterol, OK triterpene (being trade name: the manufacture of Okayasu Shoten Co., Ltd.) Deng.These commercially available oryzanol are both suitable as the oryzanol in dispersive composition of the invention.

Relative to the total amount of the total ingredient contained in dispersive composition, oryzanol in dispersive composition of the invention contains Amount is preferably the 0.1 mass % of mass %~10, more preferably 0.5 mass of mass %~5 %.

Also, in the case where containing dispersive composition of the invention in aftermentioned cosmetics of the invention, as makeup The content of oryzanol in product preferably adjusts in cosmetics in a manner of as the range of 0.0001 mass of mass %~1 % The content of dispersive composition.The preferred range of the content of oryzanol in cosmetics is 0.0003 matter of mass %~0.5 Measure %.

[surfactant containing sterol base indicated with structural formula (1)]

Dispersive composition of the invention includes surfactant (the specific table containing sterol base indicated with structural formula (1) Face activating agent).

R-O-(EO)_l-(PO)_m-(BO)_n- H structural formula (1)

In structural formula (1), EO indicates that Oxyranyle, PO indicate that propylene oxide base, BO indicate epoxy butane base.

R indicates the sterol in the group being made of phytosterol base, cholesteryl, phytostanyl base and cholesteric alkyl Base.

L indicates that the connective number of Oxyranyle, m indicate that the connective number of propylene oxide base, n indicate the connection of epoxy butane base Number, l+m+n are 5 or more and 80 or less.

Specific surfactant contained by dispersive composition of the invention is with by cholesterol skeleton, phytosterol bone The nonionic surfactant for the hydrophobic group that the polycyclic skeleton such as frame contains as part-structure.

In addition, in the present specification, the polycyclic skeletons such as cholesterol skeleton, phytosterol skeleton will be contained as part-structure Hydrophobic group be referred to as " sterol base ".

It is believed that in order to make the paddy dimension with the triterpene and sterol backbone as same or like cyclic structure Element and compound A are steadily scattered in dispersive composition, the sterol possessed by specific surfactant as hydrophobic group The volume of base is big and there is big planar structure to be very important.

In structural formula (1), R is indicated selected from by phytosterol base, cholesteryl, phytostanyl base and cholesteric alkyl structure At group in sterol base.

As phytosterol base, can enumerateSitosterol base, campesterol base, stigmasterol, brassicasterol etc..As plant Object gonane base, can enumerate hydrogenationSitosterol ester group, campesterol base, stigmasterol, brassicasterol etc..As cholestane Base can enumerate the cholesteryl of hydrogenation.The specific surfactant of sterol base with the substituent group illustrated selected from these is equal It can use in dispersive composition of the invention.

Also, as the hydrophilic group of specific surfactant, EO is ethylene oxide, and PO is propylene oxide, and BO is epoxy fourth Alkyl, l+m+n are 5 or more and 80 or less.

In the specific surfactant indicated with structural formula (1), from the point of view of the easness obtained, hydrophilic group can be enumerated Use the specific surfactant for containing sterol base of structural formula (2) expression as preferred example for EO.

R-O-(EO)_l- H structural formula (2)

In structural formula (2), R is indicated selected from by phytosterol base, cholesteryl, phytostanyl base and cholesteric alkyl structure At group in sterol base.

EO indicates Oxyranyle, and the range of l is 5~60.In structural formula (2), the range of more preferable l is 10~50, From the viewpoint of dispersion stabilization, further preferred range is 10~30.

As the surfactant indicated with structural formula (1) or with structural formula (2) indicate surfactant it is specific Example, can enumerate POE phytosterol ether, POE/POP phytosterol ether, POE/POP/POB phytosterol ether, POE/POB plant Sterol ether, POE phytostanyl alcohol ether, POE/POP phytostanyl alcohol ether, POE/POP/POB phytostanyl alcohol ether, POE/POB plant Object gonane alcohol ether, POE cholesterol ethers, POE/POP cholesterol ethers, POE/POP/POB cholesterol ethers, POE/POB cholesterol ethers, POE cholestane alcohol ether, POE/POP cholestane alcohol ether, POE/POP/POB cholestane alcohol ether, POE/POB cholestane alcohol ether etc..

Among these, it can also be obtained with the surfactant that structural formula (2) indicate with commercially available product.Tool as commercially available product Body example, as POE phytosterol ether can enumerate NIKKOL series BPS-5, BPS-10, BPS-20, BPS-30 (more than, quotient The name of an article: Nikko Chemicals Co., Ltd. manufacture), as POE phytostanyl ether can enumerate BPSH-25 (trade name: Nikko Chemicals Co., Ltd. manufacture).As POE cholesterol ethers can enumerate EMALEX series CS-5, CS-10, CS-15, CS-20, CS-24, CS-30 (more than, trade name: Nihon emulsion Co., Ltd. manufacture).

In the surfactant indicated with structural formula (1) and the concrete example of the surfactant indicated with structural formula (2) In, POE indicates the polyoxyethylene groups that multiple Oxyranyles (EO) link, and POP indicates multiple propylene oxide bases (PO) even Polyoxypropylene base made of knot, POB indicate the polybutylene base that multiple epoxy butane bases (BO) link.Above-mentioned particular surface The range of the sum for EO, PO and the BO for including in the concrete example of activating agent is 5~80.

If described, as specific surfactant according to the present invention, preferably contain polyoxyethylene (POE) structure The nonionic surfactant of (POE yl).And then be believed that in specific surfactant, by as hydrophily Polyoxyethylene (POE) base of group and as between the sterol base of hydrophobic group import polyoxypropylene (POP) base, oryzanol it is solvable Change amount more improves.

That is, being reported as follows: commonly known in the nonionic surfactant containing the POE base as hydrophilic radical In agent, solubilized performance possessed by surfactant is improved by importing POP base between hydrophilic radical and hydrophobic group, In the surfactant containing sterol base being used in the present invention, also by addition to importing POE base, POP base, molecule are also imported The ratio of interior shared hydrophobic group becomes larger, therefore can make more lyophobic dusts solubilized (with reference to FRAGRANCE JOURNAL2009-11, P34).

From the record of the document it is also contemplated that further importing POP base, POB base other than importing POE base Deng the surfactant containing sterol base in, also can with only with POE base the surfactant phase containing sterol base Together, it was confirmed that can be realized the dispersion stability of oryzanol.

Commercially available product is able to use as the specific surfactant being used in the present invention.As can make in the present invention Commercially available product, for example, EMALEX series in CS-5, CS- 10, CS-15, CS-20, CS-24, CS-30 (with On, trade name: Nihon Emulsion Co., Ltd manufacture), BPS-5, BPS-10, BPS-20, BPS- in NIKKOL series 30, BPSH-25 (more than, trade name: Nikko Chemicals Co., Ltd manufacture) etc..

Wherein, preferably CS-10, CS-20, CS-24, CS-30, BPS-10, BPS-20, BPS- 30, BPSH-25.

Specific surfactant can be used alone or two or more kinds may be used.As long as also, not damaging the present invention Effect, then specific surfactant and structure the other surfaces activating agent different from specific surfactant also can be used together (hereinafter referred to as other surfaces activating agent).As other surfaces activating agent, can enumerate selected from nonionic surfactant, yin The other surfaces activating agent of ionic surfactant, cationic surfactant and amphoteric surfactant.It is being used in combination In the case where specific surfactant and other surfaces activating agent, preferably other surfaces activating agent is nonionic surfactant.

From the viewpoint of dispersion stabilization, by quality ratio, relative to the content of oryzanol, dispersed combination of the invention ~20 times of amounts of preferably 1.0 times of the content of the specific surfactant contained in object amounts, more preferable~10 times of amounts of 1.5 times of amounts, into one Preferably 2.0 times of step~8.0 times of amount amount.

[phosphatide]

Dispersive composition of the invention contains phosphatide.Phosphatide is also known as phosphatide, there is glycerophosphatide and sheath phosphorus Rouge.Being used in phosphatide of the invention may be any of glycerophosphatide and sphingomyelins.Wherein, from more raising paddy dimension From the viewpoint of the dispersibility of element, preferably glycerine phosphatide, as glycerophosphatide, more preferable lecithin etc..

Refer to phosphatidyl choline in chemical aspect as the preferred lecithin of phosphatide in the present invention, but is industrially then Using various phosphatide as the usual title of the lipid mixtures of principal component, used in the present invention with the meaning of the latter.

The representative phosphatide contained in lecithin industrially can enumerate phosphatidyl choline (hereinafter, sometimes referred to as PC), phosphatidyl-ethanolamine (PE), phosphatidylinositols (PI) and phosphatidic acid (PA) etc..

It is the master of biomembrane in all cells of the lecithin as a kind of animals and plants for being present in nature of glycerophosphatide Want constituent.Therefore, lecithin can be extracted from all animals and plants.Industrially, lecithin is with soybean or yolk Raw material manufacture will be referred to as soybean lecithin from the lecithin of soybean, will be referred to as yolk lecithin from the lecithin of yolk Rouge.Since the biocompatibility of lecithin and emulsifying ability that oil dispersed is made lotion in water are good, as food Product or emulsifier used for cosmetic are widely used.

Also, the osmosis from skin or mucous membrane transmission absorption substance is also utilized in pharmaceuticals, in pharmaceutical lipid It is used in body material, intravenous lipid emulsion, the medicine of hemorrhoid and treating for skin disease medicine etc..Mainly from cost From the point of view of viewpoint, on food applications and cosmetic use, soybean lecithin is used mostly.

The lecithin used in dispersive composition of the invention can also be used to be from soybean, from yolk The lecithin from all animals and plants represented.Wherein, the lecithin used in dispersive composition of the invention is especially excellent Choosing derives from the lecithin of soybean (hereinafter, sometimes referred to as soybean lecithin).

Soybean lecithin is manufactured and the dregs of fat of the by-product in soybean oil purification process are dried, are purified.In general, Though the content of phosphatide is soybean crude oil of the 70 mass % paste lecithin below containing 30 mass % or so, since price is low It is honest and clean, therefore paste lecithin is mostly used especially in field of food.In recent years, from the demand of the physiological activity to phosphatide itself And from the point of view of the demand to the emulsifier of more height, when manufacturing lecithin, the skills such as addition is highly purified, is fractionated and is modified Art produces performance and the different various lecithin groups of function.

Highly purified lecithin is the lecithin for carrying out de-oiling and powdered from above-mentioned paste lecithin using acetone equal solvent Rouge.For highly purified lecithin, the content of lecithin is generally 90 mass % or more.

Highly purified lecithin can also be obtained with commercially available product, for example, (the trade name: Lipoid company of phosphatidase 20 Manufacture), LECION P (trade name: Riken Vitamin.Co., Ltd manufacture), the white (trade name: Tsuji Oil of SLP The manufacture of Mills Co., Ltd.), EMULMETIK300 (trade name: Lucas Meyer Cosmetics manufacture) etc..

In dispersive composition of the invention, any of paste lecithin and highly purified lecithin can be used As phosphatide.

Other than the paste lecithin and highly purified lecithin that have described, there are also the main contents for improving PC Fractionated lecithins, the enzyme that decomposes by enzyme single stranded decomposes (haemolysis) lecithin, carries out hydrotreated hydrolecithin Etc. modified lecithins, modified lecithin can also act as the phosphatide in the present invention.

Fractionated lecithins are using the poor solubility in various solvents or to distill etc. from highly purified lecithin It operates to improve the lecithin of the content of specific phosphatide, generally commercially available is the fractionated lecithins for improving the content of PC.

The example of the commercially available product of fractionated lecithins as the content for improving PC can enumerate phosphatidase 50 and (contain 45 matter Measure % PC), phosphatide 85G (PC containing 80 mass %), phosphatide 90G (PC containing 94 mass %) (more than, trade name: The manufacture of Lipoid company), EMULMETIK900 (PC containing 50 mass %), EMULMETIK930 (contain 95 mass %'s PC) (more than, trade name: Lucas Meyer Cosmetics manufacture), SLP-PC70 and SLP-PC90 (more than, trade name: The manufacture of Tsuji Oil Mills Co., Ltd.) etc..

Modified lecithin substantially divides into hydrolecithin and enzyme decomposes lecithin.Wherein, hydrolecithin is to make Polyenoic fatty acid oxidase in lecithin structure improves photostability, carries out hydrogenation treatment and is converted to the ovum of saturated fatty acid Phosphatide.Although hydrolecithin can be preferably used in the pharmaceuticals such as cosmetics and external preparation for skin medicine, can not be in food Middle use.

The example of commercially available product as hydrolecithin has EMULMETIK320 (trade name: Lucas Meyer Cosmetics manufacture), SLP white H (trade name: Tsuji Oil Mills Co., Ltd. manufacture) etc..

The example of commercially available product as the content and the hydrotreated lecithin of further progress for improving PC, can enumerate EMULMETIK950 (trade name: Lucas Meyer Cosmetics manufacture), SLP-PC92H (trade name: Tsuji Oil The manufacture of Mills Co., Ltd.), phosphatide 90H (trade name: Lipoid company manufacture) etc..

Enzyme decomposes the lecithin that lecithin generally by enzyme selectivity decomposes the ester bond for 2 fatty acid being bonded with glycerol Rouge, in order to be distinguished with common lecithin, also referred to lysolecithin.

Compared with lecithin before modified, the water solubility of lysolecithin increases, and general emulsifying ability also increases. General method are as follows: the enzyme resolution process for being used to prepare lysolecithin is carried out to the paste lecithin as raw material, to enzyme Lecithin after resolution process carries out highly purified and obtains lysolecithin.As other manufacturing methods of lysolecithin, Also by the method for carrying out enzyme resolution process to fractionated lecithins and obtaining lysolecithin.

As can in the example of the commercially available product of representative lysolecithin used in dispersive composition of the invention, SLP white haemolysis (trade name: Tsuji Oil Mills Co., Ltd. manufacture) can be enumerated.

Also, it as other enzyme-treated lecithins other than lysolecithin, can enumerate between phosphoric acid and alkali Ester bond decomposed and the lecithin that obtains.Through the processing decompose the ester bond between phosphoric acid and alkali, from phosphatide Alkali is removed, the shape of phosphatidic acid is become, thus enzyme-treated lecithin obtained is in very strong anionic property.As indicate yin from The example of the commercially available product of the enzyme-treated lecithin of sub- property, can enumerate PA NAGASE, lysophosphatide NAGASE H (trade name: Nsgase ChemteX Corporation manufacture) etc..

The lecithin described can be used in dispersive composition of the invention.Wherein, it is especially preferred as non-hydrogen Change the highly purified lecithin and fractionated lecithins of lecithin.

As the lecithin described for being used as phosphatide, it is preferable to use the content of phosphatide is the lecithin of 70 mass % or more Rouge, the content of more preferable phosphatide are the lecithin of 80 mass % or more, and the content of further preferred phosphatide is 90 mass % or more Lecithin.

Also, the usual range of phosphatidyl choline (PC) content contained in phosphatide is the 10 mass % of mass %~100, But phosphatide used in the present invention, the preferably content of PC are the phosphatide of 20 mass of mass %~90 %, and more preferable PC's contains Amount is the phosphatide of 30 mass of mass %~80 %.

From the viewpoint of dispersion stabilization, by quality ratio, relative to the content of oryzanol, in discrete sets of the invention The content for closing lecithin used in object is preferably~20 times of amounts of 0.5 times of amount, and~10 times of amounts of more preferably 1 times amount are further excellent It is selected as~8 times of amounts of 2 times of amounts.

Dispersive composition of the invention in addition to and with oryzanol, specific surfactant and phosphatide this neccessary composition it Outside, in the range of not damaging effect of the invention, can and with various compounds.

Dispersive composition of the invention can contain water.There is no particular restriction for water, can be from tap water, natural water, pure Select to use to ultrapure waters the purpose of property such as water, distilled water, ion exchange water, pure water, Milli-Q water.In addition, Milli-Q water For the ultrapure water obtained by the Milli-Q water making device of the Ultrapure Water Purifiers as Merck Millipore company.

(polyalcohol)

The polynary of the dissolution that can be used in triterpene alcohol ferulic acid ester can also be contained in dispersive composition of the invention Alcohol.Can the polyalcohol used in dispersive composition of the invention be in the molecule with 2 or more-OH bases alcohol.

Usually as the polyalcohol used in cosmetics, preferably carbon atom number is 3~8 and the number of-OH base in molecule The polyalcohol that amount is 2~5, the polyalcohol that more preferable carbon atom number is 3~8 and the quantity of-OH base in molecule is 2~3.Make For the preferred example of the polyalcohol used in dispersive composition of the invention, can enumerate described it is common with The identical alcohol of polyalcohol used in cosmetics.

As the concrete example that can be suitble to the polyalcohol used in dispersive composition of the invention, the third two can be enumerated Alcohol, 1,3-PD, glycerol, 1,3-BDO, diethylene glycol, 1,2- pentanediol, two glycerol, dipropylene glycol etc..

Among those, from the viewpoint of the favorable solubility of triterpene alcohol ferulic acid ester, preferred diol.In glycol In, more preferable propylene glycol, 1,3-PD, 1,3-BDO, 1,2- pentanediol, diethylene glycol, dipropylene glycol etc., from biofacies From the viewpoint of capacitive, further preferred 1,3-PD, 1,3-BDO and dipropylene glycol etc..

Content when as in dispersive composition of the invention using polyalcohol, although can suitably be selected according to purpose It selects, but by quality ratio, relative to the total content of oryzanol ,~100 times of amounts of preferably 0.1 times amount, more preferable 0.5 times of amount~50 It measures again.

(oil components)

Dispersive composition of the invention is in addition to containing oryzanol, in the range of not damaging effect of the invention, Neng Gouhan With good grounds purpose is selected from the one kind or two or more oil components of the oil components other than oryzanol.Hereinafter, sometimes will be in addition to Oil components other than oryzanol are known as other oil components.

As can in other oil components used in dispersive composition of the invention, as long as such as can with change Oil components used in the corresponding usage mode of the purpose of cosmetic etc., then be not particularly limited, and can use.

Chemically from the point of view of configuration aspects, grease, hydrocarbon, wax, ester compounds, higher fatty acids, higher alcohol, high score can be enumerated Sub- compound, oil-soluble pigment and oil-soluble protein etc..

Also, the oil-soluble functional materials that contain in the animals and plants such as terpene, alkaloid, polyphenol and contain these oil-solubles Each vegetable oils of functional materials, animal oil etc. can also use in dispersive composition of the invention.Also, energy is not contained Enough each vegetable oil of the oil-soluble functional materials used in cosmetics, animal oil etc. also can be in discrete sets of the invention It closes and is used in object.

As can be in other oil components, i.e. vegetable oil, animal oil, source used in dispersive composition of the invention In the oil components of vegetable and animals oils and the example of other oil components, can enumerate coconut oil, olive oil, corn oil, flash Higher fatty acids, docosyl alcohol, stearyl alcohol, the spermaceti such as greases, stearic acid, oleic acid, palmitic acid, myristic acid, the lauric acid such as bar oil Alcohol, isooctadecanol, oleyl alcohol, decyl alcohol, dodecanol, tetradecyl alchohol, hexyl decyl alcohol, 2- octyldodecanol, 2- decyl tetradecyl alcohol etc. The sterols such as higher alcohol, cholesterol, phytosterol, brown purlin acid ethylhexyl ester, isopropyl myristate, octyl dodecanol myristic acid The ester compounds such as ester, N- lauroyl-Pidolidone two (phytosterol base 2- octyldodecyl), saualane, squalene, The hydrocarbon such as Nexbase 2004, Parleam.

Also, dispersive composition of the invention can contain following substance as functional oil components:Carrot It is the vitamin Es such as the carotenoid such as element, astaxanthin, zeaxanthin, lycopene, lutein, tocopherol, tocotrienols, auxiliary ù -3 grease type such as the ubiquinone such as enzyme Q10 and eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), linolenic acid etc..

It is preferred that dispersive composition of the invention further contains triterpene as the functional oil components of tool.

In triterpene, particularly preferably there are 5 ring triterpenes of carboxylic acid or carboxylic acid derivates.Triterpene with carboxylic acid etc. Mainly obtained from plant extracts.As the example of the triterpene obtained from plant extracts, Gotu Kola P.E can be enumerated In the asiatic acid, the brahmic acid, ursolic acid, oleanolic acid, betulinic acid, the purple perilla contained in Rosmarinus officinalis extract that contain The oleanolic acid that contains in leaf extract, ursolic acid, tormentic acid, the enoxolone contained in licorice etc..In addition to this Other than a little acid type triterpenes with carboxylic acid etc., dispersive composition of the invention can also contain the shape of the glucoside type with sugar bond The triterpene of shape (referred to as abundant glucosides (heterosides)).

Dispersive composition of the invention be further preferably containing as the asiatic acid of acid type triterpene, brahmic acid and The side for the collapse jorum (Gotu Kola P.E) that asiaticosid, madecassoside as triterpene glucoside suitably mix Formula.

Also, as the oil components for the moisture-keeping functions that can contain with dispersive composition of the invention, it is also suitable for lifting Ceramide I, ceramide II, ceramide III, ceramide V, ceramide VI isoreactivity ceramide, glucose mind out Through the glycosyl sphingolipids such as amide, galactosyl ceramide, sphingomyelins, class ceramide etc..

In the case where dispersive composition of the invention contains other oil components, preferably by other oil components and Gu Wei Element etc. is mixed and is used in advance.

Content when as in dispersive composition of the invention using other oil components, although can be suitable according to purpose Locality selection, but by quality ratio, relative to the total content of oryzanol, preferably 0.1 times~100 times of amount are measured, and more preferable 0.5 times ~50 times of amounts of amount.

Also, in addition to containing other than mentioned component, also can according to need and its mode in dispersive composition of the invention Suitably contain adding ingredient usually used in the fields such as food and cosmetics.

By characteristic possessed by each ingredient, oil-soluble or water solubility can be used as in dispersive composition of the invention Adding ingredient contain other compositions.

As can the other compositions used in dispersive composition of the invention, for example, be selected from pearly luster 1 kind or more ingredient of material, preservative, antioxidant, dyestuff and thickener or pH adjusting agent.Also, in point of the invention It is able to use aromatic in powder composition, antibacterial agent, moisturizer, ultraviolet absorbing agent, active oxygen scavenger, antioxidant, resists Microorganism agent, hair restorer, minerals and amino acid etc..

[purposes of dispersive composition]

Dispersive composition of the invention can be useful in the effective component for needing oryzanol of cosmetics, skin preparations for extenal use etc. Various uses.

[cosmetics]

Dispersive composition of the invention can be used in cosmetics.

Cosmetics of the invention contain the dispersive composition of the invention described.

Dispersive composition of the invention due to the dispersed particle containing oryzanol be preferably volume average particle size be 200nm with Under small dispersed particle, dispersibility and dispersion stabilization are excellent, therefore can be adapted for use in cosmetics.

Also, since the dispersed particle contained in dispersive composition is small, contain dispersive composition of the invention Cosmetics can fully obtain the validity of the oryzanol as functional components.In addition, due to cosmetics of the invention The dispersion stabilization of oryzanol is excellent and can inhibit to be precipitated, therefore it is excellent and the maintenance transparency for a long time excellent to obtain the transparency Different effect.

As cosmetics, can enumerate toner, beautifying liquid, lotion, creams, cream pack/facial mask, tearing type facial mask, Bottom cosmetics, hair washing apply some make up, fragrant cosmetic products, liquid body wash, antiultraviolet cosmetics, dispel smelly cosmetics and mouth Chamber nurses the cosmetics such as cosmetics.It is averaged since dispersive composition of the invention steadily contains such volume as already mentioned Partial size is 200nm small dispersed particle below, therefore is especially suitable for being useful in the aqueous cosmetic for requiring the transparency.

About toner and beautifying liquid, the transparency is required according to dosage form, and requires also to tie up after the time Hold the transparency." transparency " said here is using the turbidity described in detailed below as index.Turbidity is by utilizing wavelength 650nm's The absorbance regulation that light measures at 25 DEG C.The absorbance (turbidity) of index as " transparency " in cosmetics of the invention It is measured using spectrophotometer (V- 630, JASCO Corporation manufacture).

Compare visible wavelength in the partial size d of dispersive compositionHour, dispersive composition and turbidityRelationship can be to Following formula A is indicated.

[numerical expression 1]

As shown in formula A, for turbidityAssign the partial size d, the population n and finish of dispersive composition of dispersive composition Relative index of refraction m.Here, the population n of dispersive composition passes through the oily dose designation in dispersive composition.As long as containing The cosmetics of dispersive composition of the invention, then the use level regulation that its turbidity passes through the dispersive composition in cosmetics.

Preferably contain dispersion of the invention using the suitable mode of cosmetics made of dispersive composition of the invention Composition and the absorbance (turbidity) for utilizing the light measurement of wavelength 650nm are 0.15 cosmetics below, the more preferably extinction Degree is 0.1 cosmetics below.

The turbidity of cosmetics is preferably 0.001~0.15.Absorbance (turbidity) is more preferably 0.001~0.125, into one Step preferably 0.001~0.1.

Cosmetics of the invention contain dispersive composition.It is preferred that being become with the oryzanol content in cosmetics of the invention The mode of the range of 0.0001 mass of mass %~1 % adjusts the content of dispersive composition, more preferably with cosmetics of the invention In oryzanol content adjust the content of dispersive composition as the mode of the range of 0.0003 mass of mass %~0.5 %.

About cosmetics of the invention, such as pass through blender stirring, impeller stirring and stirring using mixer for well-distribution Mix, each ingredient contained in cosmetics mixed etc., so as to prepare dispersive composition of the invention and according to Need can ingredient.

Hereinafter, the manufacturing method of dispersive composition of the invention is described in detail.

[manufacturing method of dispersive composition]

The manufacturing method of dispersive composition of the invention is not particularly limited, and can be manufactured according to known methods.

As general manufacturing method, for example, including will be containing oryzanol, specific surfactant and more The manufacturing method for the mixed processes that the oil-phase component of first alcohol is mixed with the water-phase component containing phosphatide and water.

Hereinafter, enumerating specific manufacturing method to be illustrated, but the manufacturing method of dispersive composition of the invention is not It is defined in following record.

(dispersing method)

It is added to as the aqueous dispersing composition for dispersing oryzanol according to the present invention in water phase and obtaining In the case where cosmetics, dispersive composition can be manufactured by the following method out.In addition, following methods are dispersive composition autofrettage An example, be not limited to following methods.

(mixed processes)

When preparing dispersive composition, after oryzanol can also being dissolved by heating in advance in specific surfactant, It is added in the water phase containing phosphatide.Also, in order to more improve dispersion efficiency, more preferably in advance by oryzanol in particular surface After being dissolved by heating in activating agent and polyalcohol, it is added in water phase.

It, first will be as the oryzanol of compound according to the present invention and specific table if enumerating an example of manufacturing method Face activating agent is mixed in polyalcohol liquid, is dissolved by heating to 70 DEG C~150 DEG C, to prepare uniform oily solution.

In the water phase containing the phosphatide for being heated to 40 DEG C~90 DEG C, it is molten to mix oiliness obtained for addition while stirring Liquid.Commercially available any hybrid component also can be used in the mixed processes.

That is, being able to use magnetic stirring apparatus, home-use mixer, arm mixer, impeller mixer as hybrid component Equal devices, are mixed oily solution and aqueous medium, to prepare uniform suspension.

Also, such as more preferably oryzanol is being dissolved by heating to polyalcohol in advance, be added in water phase.

(good pressure distribution process)

Also, it is preferable to use microminiaturization components to carry out microminiaturization for the dispersed particle containing oryzanol to prepare discrete sets Object is closed, which is the agitating member with the stronger shearing force of hybrid component than having described, that is, uses homogeneous The high-speed mixing method of mixer, dispersing mixer, super mixer etc., using ultrasonic wave harmonious material device supercritical ultrasonics technology, use high pressure The high pressure harmonious material device method etc. of harmonious material device application high shear force.

As the example of ultrasonic wave harmonious material device, ultrasonic wave harmonious material device US-600, ultrasonic wave harmonious material device US- can be enumerated 1200T, ultrasonic wave harmonious material device RUS-1200T, ultrasonic wave harmonious material device MUS-1200T (more than, NISSEI Corporation system Make), processor for ultrasonic wave UIP2000, processor for ultrasonic wave UIP-4000, processor for ultrasonic wave UIP-8000, ultrasonication Device UIP-16000 (more than, the manufacture of Hielscher company) etc..These high output ultrasonic wave irradiation units are with 25kHz or less, excellent Select the frequency usage of 15~20kHz.

As the example of high pressure harmonious material device, can enumerate microfluidizer (manufacture of Microfluidics company), NANOMIZER (manufacture of Yoshida Kikai Co., Ltd.), STARBURST (Sugino Machine Limited manufacture), GAULIN formula harmonious material device (manufacture of APV company), LANNIER formula harmonious material device (manufacture of LANNIER company), high pressure harmonious material device (Niro Soavi company manufacture), HOMOGENIZER (manufacture of Sanwa Machinery Trading Co., Ltd.), high pressure HOMOGENIZER (manufacture of Izumi Food Machinery Co., Ltd.), super-pressure harmonious material device (manufacture of IKA company) etc..

From the viewpoint of the microminiaturization of dispersed particle, the operating pressure of high pressure harmonious material device preferred 50MPa or more is more excellent Select 150MPa or more.Also, the road number of HIGH PRESSURE TREATMENT is also possible to 1 time, but in order to improve the uniform of entire dispersive composition Property, road number is preferably 2 times or more, and more preferably 2 times~5 times.

Temperature before good pressure distribution processing is set as 20 DEG C~80 DEG C, but more preferably 40 DEG C~70 DEG C.It is preferred that discrete sets It closes object promptly to be cooled down using cooling component soon after good pressure distribution processing, is reduced to defined temperature.As cold But device is able to use commercially available any heat exchanger.

(other processes)

After preparing dispersive composition of the invention, if necessary, then there can be sterilization process.

Sterilization process can also be carried out in the either phase in each process for preparing dispersive composition of the invention, but into When row sterilization process, preferably implement as rapidly as possible after being stirred process or good pressure distribution process.

(sterilizing methods)

As the sterilizing methods in sterilization process, for example, the side by heating such as hot air sterilization, steam sterilizing Method, electron-beam sterilization, the sterilizing carried out by ionization radial line, the method to be sterilized by electromagnetic wave by sterilizing of high frequency etc., Gaseous sterilizations, hydrogen peroxide low-temperature plasma sterilization, the chemosterilants such as ethylene oxide gas (EOG) sterilizing etc. are made by chemistry With the method for sterilizing and filtration sterilization etc. by separating the method for removing sterilizing.In the manufacture of dispersive composition of the invention In, the preferred heat sterilization of sterilizing methods (hot air sterilization, steam sterilizing) and filtration sterilization.

(partial size of dispersive composition)

The volume average particle size of the dispersed particle containing oryzanol in dispersive composition of the invention be preferably 5nm~ 200nm, more preferably 5nm~100nm, further preferably 5nm~50nm.

Consider from particle size range and the easness of measurement, the partial size of the dispersed particle in the present invention is applicable in by dynamic The volume average particle size that state light scattering method is found out.

(particle size determination)

As the commercially available particle size determination device for using dynamic light scattering, NANOTRAC UPA (Nikkiso can be enumerated Co., Ltd.), dynamic light scattering formula particle size distribution analyzer LB-550 (Horiba, Ltd.), central system particle size analyzer FPAR-1000 (Otsuka Electronics Co., Ltd.) etc..

The volume average particle size of dispersed particle in the present invention be by using NANOTRAC UPA (Nikkiso Co., Ltd.) the value measured is specific using the value measured by the following method.

About the measuring method of partial size, dispersive composition of the invention is diluted to 10 times with pure water, at room temperature (25 DEG C) Under be measured.It finds out and uses 1.333 (pure water) as decentralized medium refractive index, use pure water as the viscosity of decentralized medium Volume average particle size when viscosity.

Embodiment

Hereinafter, by embodiment, the present invention is described in detail.However, the present invention is not limited to any embodiments.

In addition, oryzanol and compound A are known as " (A) ingredient " sometimes in the present embodiment.

(embodiment 1-1~embodiment 1-4, comparative example 1-1~comparative example 1-5)

[preparation of dispersive composition]

According to the formula recorded in following table 1~2, in the glycerol as polyalcohol, by (A) ingredient in table 1~2 It is mixed with surfactant (specific surfactant or comparison surface activating agent), is heated with 70 DEG C~150 DEG C of temperature Dissolution, prepares uniform oily solution.

Used in the present embodimentOryzanol (24-methylenecycloartanyl ferulate: trade name, Okayasu Shoten Co., Ltd. system Make) contain at least one kind of compound A as effective component.

In addition, numerical value involved in the content recorded in following table indicates quality % there is no illustrating.

Containing purification lecithin (phosphatide, SLP white (trade name) Tsuji Oil for being heated to 40 DEG C~90 DEG C Mills Co., Ltd. manufacture), purification in the water phase containing pure water etc., add oily solution obtained while stirring, Obtain suspension.By with 20 DEG C or more and 80 DEG C of temperature below under the pressure of 100MPa or more to suspension obtained Liquid carries out decentralized processing, obtains the dispersive composition of embodiment 1-1 to embodiment 1-4 and comparative example 1-1 to comparative example 1-5.

[evaluation of dispersive composition]

The evaluation of dispersive composition obtained is implemented as follows, by result and remembers in 1~table of table 2.

(particle size determinations of 1. dispersive compositions)

As the commercially available measurement device for using dynamic light scattering, using NANOTRAC UPA (Nikkiso Co., Ltd. the partial size of the dispersed particle contained in dispersive composition obtained) is measured as follows.

Dispersive composition is diluted to 10 times with pure water, the measurement of partial size is carried out under room temperature (25 DEG C).Find out use The decentralized medium refractive index of 1.333 (pure water), by the viscosity of pure water be used as decentralized medium viscosity when dispersive composition in The volume average particle size of dispersed particle.

In addition, the volume of the dispersed particle contained in the dispersive composition after preparation is averaged in following table 1~table 7 Partial size is recorded as " initial particle ".

(evaluation of 2. dispersion stabilizations)

It is implemented down after dispersive composition obtained is stored 2 weeks at 40 DEG C as the evaluation of dispersion stabilization State 2 projects.

(appearance of 2-A. dispersive composition)

The dispersive composition stored after 2 weeks at 40 DEG C is observed by visual observation, and whether there is or not contain in dispersive composition for confirmation The separation of any ingredient or be precipitated and the phenomenon that causes the uniformity of dispersive composition impaired.

(2-B. particle size determination)

For the dispersive composition after being stored at 40 DEG C 2 weeks, in a manner of identical with above-mentioned " 1. particle size determination ", survey The volume average particle size for determining dispersed particle calculates the variation of the partial size of time process front and back, evaluates dispersion stabilization.

In addition, in following table 1~table 7, the dispersible granule that will contain in the dispersive composition after being stored at 40 DEG C 2 weeks The volume average particle size of son is recorded as " partial size after 40 DEG C of 2w ", and the volume of the dispersed particle before and after storage dispersive composition is averaged The variation of partial size is recorded as " 40 DEG C of 2w change of size ".

As the judgement benchmark of dispersion stabilization, evaluated based on following evaluation criterions.As long as being benchmark A~C, It is judged as the rank that there is no problem in practical.

The dispersion stabilization evaluation criteria-of dispersive composition

A: change of size is less than 10nm

B: change of size is 10nm more than and less than 25nm

C: change of size is 25nm more than and less than 50nm

D: change of size is 50nm or more, can either see precipitation or separation

Table 1

Table 2

By the result of table 1~2 it is found that the dispersive composition of embodiment 1-1~1-4 it is obtained containingOryzanol The partial size of dispersed particle is extremely small, and dispersion stabilization is also excellent.

On the other hand, comparative example 1-1~comparative example 1-5 of comparison surface activating agent is used instead of specific surfactant Initial dispersion partial size is big compared to the examples, for dispersive composition, and shows with time going by because the outer of generation is precipitated Variation in sight, dispersion stabilization are poor.

(embodiment 1-5~embodiment 1-10)

According to the formula recorded in following Table 3~4, prepare dispersive composition in a manner of identical with embodiment 1-1, with The identical mode of embodiment 1-1 is evaluated.By result and remember in following Table 3~4.In addition, compare control for convenience, and The result of embodiment 1-1 and embodiment 1-2 are remembered.

Table 3

Table 4

By the result of table 3~4 it is found that the dispersive composition of embodiment 1-5~1-10 it is obtained containingOryzanol Dispersed particle partial size it is extremely small, dispersion stabilization is also excellent.

Also, the bond number of the EO in the specific surfactant used in embodiment 1-5~1-10 is 5~30, Any embodiment all obtains excellent effect.Wherein, the range that the bond number of the EO in specific surfactant is 10~30, Thus dispersion particle diameter becomes smaller, and dispersion stabilization shows more excellent tendency.

(embodiment 1-11~embodiment 1-13, comparative example 1-6)

According to the formula recorded in following table 5, prepare dispersive composition in a manner of identical with embodiment 1-1, with reality The identical mode of a 1-1 is applied to be evaluated.By result and remember in following table 5.In addition, comparing control for convenience, and reality is remembered Apply the result of a 1-1.

Table 5

As shown in Table 5, the dispersive composition of embodiment 1-11~1-13 it is obtained containingOryzanol The partial size of dispersed particle is extremely small, and dispersion stabilization is also excellent.

Also, the content of the specific surfactant in the dispersive composition of embodiment 1-11~1-13 is 1.25 matter The range of the mass of %~6.00 % is measured, any embodiment all achieves excellent effect.Wherein, the content of specific surfactant In the range of 1.25 mass of mass %~6.00 %, as specific surfactant is more containing quantitative change, show dispersion particle diameter change Obtain smaller tendency.On the other hand, in the comparative example 1-6 without containing specific surfactant, stable point is not obtained Powder composition.

(embodiment 1-14)

According to the formula recorded in following table 6, the type of phosphatide is changed as recording in table 6, in addition to this, with reality It applies the identical mode of a 1-1 and prepares dispersive composition, evaluated in a manner of identical with embodiment 1-1.By result and remember In following table 6.In addition, comparing control for convenience, the result of embodiment 1-1 is gone back and remembered.

Table 6

As shown in Table 6, the dispersive composition of embodiment 1-14 it is obtained containingThe dispersible granule of oryzanol The partial size of son is extremely small, and dispersion stabilization is also excellent.As phosphatide, in the reality using purification lecithin and hydrolecithin It applies in example, it can be found that anyOryzanol can steadily disperse.It specifies for improving the haemolysis lecithin after enzyme decomposes The fractionated lecithins of the content of rouge or phosphatidyl choline can also obtain good dispersive composition.Wherein, purification ovum has been used The result of the embodiment 1-1 of phosphatide is that dispersion particle diameter is smaller, and dispersion stabilization is also excellent.

(embodiment 1-15~embodiment 1-17, comparative example 1-7)

According to the formula recorded in following table 7, prepare dispersive composition in a manner of identical with embodiment 1-1, with reality The identical mode of a 1-1 is applied to be evaluated.By result and remember in following table 7.In addition, comparing control for convenience, and remember The result of embodiment 1-1.

Table 7

As shown in Table 7, the dispersive composition of embodiment 1-15~1-17 it is obtained containingOryzanol The dispersibility of dispersed particle, dispersion stabilization are excellent.

Wherein, by the way that the content of phosphatide is set as 2.00 mass % or more, superior dispersibility and dispersion are realized Stability.On the other hand, in the comparative example 1-7 without containing phosphatide, oryzanol is precipitated with time going by, can not obtain Stable dispersive composition.

(embodiment 2-1)

(cosmetics)

(preparation of the emulsification composition containing astaxanthin)

Following compositions are heated and dissolved 1 hour with 70 DEG C, aqueous phase composition A is obtained.

Following compositions are heated and dissolved 1 hour with 70 DEG C, oil phase composition A is obtained.

In the state that the aqueous phase composition A of above-mentioned acquisition is maintained at 70 DEG C, using harmonious material device (machine name: HP93, SMT Corporation manufacture) it is stirred (10000rpm), oil phase composition A is added to aqueous phase composition A, is obtained pre- Emulsion processed.

Then, prefabricated emulsion obtained is cooled to about 40 DEG C, uses ULTIMAIZER HJP-25005 (Sugino Machine Limited manufacture) with the pressure progress high-pressure emulsification of 200MPa.Later, it is carried out with the microstrainer of 1 ì m of average pore size Filtering is to prepare the emulsification composition (astaxanthin containing ratio: 0.3 mass %) containing astaxanthin.

Astaxanthin emulsification composition obtained is diluted to 1 mass % with Milli-Q water, uses particle size analyzer The partial size that FPAR-1000 (Otsuka Electronics Co., Ltd.) measures dispersed particle is 58nm.

Toner (cosmetics of embodiment 2-1) (100 matter of total amount with following compositions is prepared according to conventional methods Measure %).

It is 0.008 by the turbidity that the method described measures toner obtained, it is thus identified that the transparency is good.

After cosmetics are stored 2 weeks at 40 DEG C, the turbidity of the cosmetics after measurement storage in an identical manner, confirmation The rate of change for storing the turbidity of front and back, is evaluated according to following determinating reference.It as a result is A.

(turbidity estimation of stability benchmark)

A: turbidity change rate is less than 110%

B: turbidity change rate is 110% more than and less than 130%

C: turbidity change rate is 130% or more

[embodiment 2-2~2-5]

The beautifying liquid (100 mass % of total amount) with following compositions is prepared according to conventional methods.

The turbidity that cosmetics obtained are measured in a manner of identical with embodiment 2-1 is 0.010~0.013, it is thus identified that It is transparent good.It shows the results of the evaluation in following table 8.

Cosmetics after cosmetics are stored 2 weeks at 40 DEG C, after storage is measured in a manner of identical with embodiment 2-1 Turbidity, confirmation storage front and back turbidity stability bandwidth, evaluated according to the determinating reference described, result is A.It will Evaluation result is shown in following table 8.

Table 8

[embodiment 2-6]

The creams (100 mass % of total amount) with following compositions are prepared according to conventional methods.

[embodiment 2-7]

The sun-screening agent (100 mass % of total amount) with following compositions is prepared according to conventional methods.

[embodiment 2-8]

The lotion with following compositions is prepared according to conventional methods.Firstly, preparation containing following oil-phase components oil mutually and Water phase containing following water-phase components, by mutually mixing oil obtained with water phase, to prepare lotion.In embodiment The emulsification composition containing oryzanol prepared in 1-1 is contained in water phase.(100 mass % of total amount).

[embodiment 2-9]

The gluey beautifying liquid with following compositions is prepared according to conventional methods.(100 mass % of total amount).

[embodiment 2-10]

Production contains the ingredient recorded in following compositions and the slurry of the water as decentralized medium, filling to defined container In, dry removal decentralized medium has made the solid powder cosmetic material of following compositions.(100 mass % of total amount).

[embodiment 2-11]

(preparation of the aqueous dispersing composition containing Gotu Kola P.E)

By the way that following ingredients is carried out mixing and is dissolved 30 minutes with 70 DEG C in heating with blade, suspension is obtained A。

* 1:TECA (trade name) (Bayer HealthCare company manufacture, containing as 5 ring triterpenes asiatic acid, The mixture of brahmic acid and asiaticosid)

In the state of keeping the suspending liquid A obtained among the above at 60 DEG C, 5 super-pressure point are passed through with the pressure of 200MPa Dissipate machine (machine name: STARBURST MINI, Sugino Machine Limited manufacture), the processing of Lai Jinhang good pressure distribution, system The standby aqueous dispersing composition containing Gotu Kola P.E out.

The aqueous dispersing composition obtained containing Gotu Kola P.E is diluted to 10 times with Milli-Q water, with dynamic State light scatters formula partial size test machine, and (machine name: NANOTRAC UPA (manufacture of Nikkiso Co., Ltd.) measures dispersed particle Partial size is 19nm.

The foundation emulsion (W/O emulsion) (100 mass % of total amount) of following compositions is made according to conventional methods.

In above-mentioned composition, * 1~* 4 have used following pigment.In addition, embodiment 2-12~embodiment 2-14 composition In * 1~* 4 be also pigment as shown below.

* 1 specific red composite pigment: HNB RED7 (trade name: Daito Kasei Kogyo Co., Ltd. manufacture)

* 2 extender pigments: (being trade name: Daito by OTS-2 SERICITE PSE and OTS-2TALK JA-46R The manufacture of Kasei Kogyo Co., Ltd.) with the product of 7: 3 ratio mixing

* 3 color material pigment: by OTS-2 TiO₂CR-50, OTS-2 YELLOW LLXLO, 2 OTS- RED R-516L and OTS-2 BLACK BL-100 (being trade name: the manufacture of Daito Kasei Kogyo Co., Ltd.) is with 78: 19: 1: 2 ratio The product of example mixing

* 4 pearlescent pigments: by RONAFLAIR BALANCE GOLD and TRANS PRISMA RED (be trade name: The manufacture of Merck company) with the product of 7: 3 ratio mixing

[embodiment 2-12]

The foundation emulsion (W/O emulsion) (100 mass % of total amount) with following compositions has been made according to conventional methods.

[embodiment 2-13]

The foundation emulsion (W/O emulsion) (100 mass % of total amount) with following compositions has been made according to conventional methods.

[embodiment 2-13]

The foundation emulsion (W/O emulsion) (100 mass % of total amount) with following compositions has been made according to conventional methods.

[embodiment 2-14]

The foundation emulsion (W/O emulsion) (100 mass % of total amount) with following compositions has been made according to conventional methods.

[embodiment 2-15]

It is prepared for the facial cleanser (100 mass % of total amount) with following compositions according to conventional methods.

[embodiment 2-16]

It is prepared for the facial cleanser (100 mass % of total amount) with following compositions according to conventional methods.

[embodiment 2-17]

It is prepared for the facial cleanser (100 mass % of total amount) with following compositions according to conventional methods.

The cosmetics of embodiment 2-6~2-17 all have good use feeling.

The disclosure of Japanese patent application 2014-52465 is by reference to being incorporated in this theory filed on March 14th, 2014 In bright book.

With with specific and phase the case where record respectively by reference to quoting each document, Japanese patent application and technical standard Same degree, by reference to all documents, Japanese patent application and the technical standard recorded in this specification are incorporated in this In specification.

Claims (12)

1. a kind of dispersive composition, the surfactant containing sterol base that is indicated containing oryzanol, with structural formula (1) and Phosphatide,

R-O-(EO)_l-(PO)_m-(BO)_n- H structural formula (1)

In structural formula (1), EO indicates that Oxyranyle, PO indicate that propylene oxide base, BO indicate epoxy butane base；R indicates choosing The sterol base in group that free phytosterol base, cholesteryl, phytostanyl base and cholesteric alkyl are constituted；L+m+n is 5 or more And 80 or less.

2. a kind of dispersive composition, contain selected from the compound by being indicated with structural formula (3) and with structural formula (4) expression Compound constitute group at least one kind of compound A, with structural formula (1) indicate the surfactant containing sterol base and Phosphatide,

In structural formula (3) and structural formula (4), R³And R⁴Separately indicate the straight-chain or tool of carbon atom number 1~10 There are the alkyl of branch or the straight-chain of carbon atom number 1~10 or an alkenyl with branch, alkyl and alkenyl can also be with With at least one substituent group in the group being made of the oxoalkyl group of carbon atom number 1~3 and OH base,

R-O-(EO)_l-(PO)_m-(BO)_n- H structural formula (1)

In structural formula (1), EO indicates that Oxyranyle, PO indicate that propylene oxide base, BO indicate epoxy butane base；R indicates choosing The sterol base in group that free phytosterol base, cholesteryl, phytostanyl base and cholesteric alkyl are constituted；L+m+n is 5 or more And 80 or less.

3. dispersive composition according to claim 2, wherein

Compound A includes to constitute selected from the compound by being indicated with structural formula (5) and with the compound that structural formula (6) indicate At least one kind of compound in group,

In structural formula (5), R⁵Indicate the 1 valence substituent group in structure as shown below,

In structural formula (6), R⁶Indicate the 1 valence substituent group in structure as shown below,

4. dispersive composition according to claim 1, wherein

The surfactant containing sterol base indicated with structural formula (1) includes with structural formula (2) expression containing sterol base Surfactant,

R-O-(EO)_l- H structural formula (2)

In structural formula (2), EO indicates that Oxyranyle, R are indicated selected from by phytosterol base, cholesteryl, phytostanyl base And the sterol base in the group of cholesteric alkyl composition；L is 5 or more and 60 or less.

5. dispersive composition according to claim 2, wherein

The surfactant containing sterol base indicated with structural formula (1) includes with structural formula (2) expression containing sterol base Surfactant,

R-O-(EO)_l- H structural formula (2)

In structural formula (2), EO indicates that Oxyranyle, R are indicated selected from by phytosterol base, cholesteryl, phytostanyl base And the sterol base in the group of cholesteric alkyl composition；L is 5 or more and 60 or less.

6. dispersive composition according to claim 3, wherein

The surfactant containing sterol base indicated with structural formula (1) includes with structural formula (2) expression containing sterol base Surfactant,

R-O-(EO)_l- H structural formula (2)

In structural formula (2), EO indicates that Oxyranyle, R are indicated selected from by phytosterol base, cholesteryl, phytostanyl base And the sterol base in the group of cholesteric alkyl composition；L is 5 or more and 60 or less.

7. dispersive composition according to claim 1, wherein phosphatide is lecithin.

8. dispersive composition according to claim 2, wherein phosphatide is lecithin.

9. dispersive composition according to claim 1, wherein the dispersive composition contains average grain diameter less than 200nm Dispersed particle.

10. dispersive composition according to claim 2, wherein the dispersive composition contains average grain diameter less than 200nm Dispersed particle.

11. a kind of cosmetics contain dispersive composition described in any one of claims 1 to 10.

12. cosmetics according to claim 11, wherein the turbidity of the cosmetics is 0.1 or less.