CN1061257C - Chinese medicine pellet 'Qufengdan' for rheumatoid disease and its preparation - Google Patents

Abstract

The present invention discloses a medicine for treating rheumatoid disease and expelling wind. Nux vomica, common monkshood mother root and centipede are used as raw materials; according to the physical and chemical properties of each kind of traditional Chinese medicine, the raw materials are respectively processed into have the fineness of 80 meshes, and then are prepared into medicinal powder, tablets or capsules.

Description

Treat rheumatoid Chinese patent medicine and preparation method thereof

The present invention relates to a kind of is that raw material is treated rheumatoid medicine and is method for preparing raw material with the Chinese herbal medicine with the Chinese herbal medicine.

Rheumatoid disease medically is called as " the strict joint wind of white tiger " in motherland, modern medicine thinks that it is sick complicated, and the cause of disease does not still have final conclusion so far.Rheumatoid disease is the commonly encountered diseases of serious harm human health, frequently-occurring disease, treatment difficulty, thus the title of " stupid low " is arranged, the mortality height, patient's misery, most of patients be disability and self care ability to some extent.Show that according to interrelated data the U.S.'s 200,000,000 populations just have 2,000 ten thousand people to suffer from this disease in various degree; Just there are 240,000 people to suffer from this disease in Sweden's 5 million people's mouths.China is a large agricultural country, nearly 800,000,000 agricultural populations, and throughout the year open-air farming, it is more to suffer from this patient.

At present, both at home and abroad to treat rheumatoid in, down tens of kinds in Western medicine, though the curative effect of the degree of having nothing in common with each other is symptomatic treatment, the respite symptom, most medicines clothes for a long time are then invalid or have side effects.

The object of the present invention is to provide a kind of Comprehensive Treatment rheumatoid disease that has, the effect of enhancing body autoimmune ability is the Chinese patent medicine of the raw material DANJI its preparation method that dispels the wind with the Chinese herbal medicine.

The rheumatoid Chinese patent medicine of treatment of the present invention (claiming to dispel the wind pellet again) is based on motherland's medical science to rheumatoid understanding and treatment experience, and modern medicine clinical practice, the ability of enhancing human body immunity effectively that from a large amount of preparation programs, filters out, and can the Comprehensive Treatment rheumatoid disease.

Medicine of the present invention is by 100 parts of the formulated Semen Strychni of following component, 40 parts of Radix Aconitis, 30 parts of Scolopendras, (being weight portion).Its preparation method is:

1. get Semen Strychni and be soaked in the Freshman urine, and replacing remains freshly voided urine at any time.Semen Strychni adsorbs human urine gradually, Semen Strychni weight increases with absorption Urina Hominis liquid measure, never degenerate under the condition keeping human urine, treat that Semen Strychni increases weight after 1.5-2 times, taking-up is cleaned with clear water, the peeling lint, cut into slices according to a conventional method, dry, oil immersion is fried to crisp, it is standby to be ground into 80 order fineness;

2. getting Radix Aconiti, Semen phaseoli radiati, Radix Glycyrrhizae goes into pot and adds and flooded powder and boil, the weight proportion of Radix Aconiti, Semen phaseoli radiati, Radix Glycyrrhizae is 10: 0.5: 0.5, simmers in water to the saturating heart after boiling, and promptly Semen phaseoli radiati is bloomed, take out Radix Aconiti and fry in hot sand to dried shortcake, it is standby to be ground into 80 order fineness;

3. it is crisp to get the Scolopendra baking, is ground into 80 order fineness

With the Semen Strychni after the above-mentioned processing, Radix Aconiti, Scolopendra in 10: 4: 3 (weight) ratio mixings.

4. mixture behind the above-mentioned mixing can directly use as powder, or incapsulate into capsule formulation, also can add excipient granulations such as starch again, is pressed into tablet.

Chinese patent medicine of the present invention has carried out a large amount of scientific experimentss at aspects such as clinical, preparation, production technology, biochemistry and toxicity.

The pharmacological evaluation of Chinese patent medicine of the present invention: have analgesic antiphlogistic, improve the focus function of joint, certain adjusting immunity function is arranged.Patient blood hemoglobin is raise, improve anemia, rheumatoid factor part the moon is often become a full member, the erythrocyte sedimentation rate of rising descends, and it is normal that the immunoglobulin that increases unusually (IgG and IgM) recovers.Simultaneously, can also eliminate pain, arthroncus, spasm is tetanic.Muscle atrophia, double paralysed patient has and slows down or cure, recovers the human body basic function.The deformity severe patient had alleviate and control action.

Chinese patent medicine toxicity of the present invention is observed:

Acute, subacute and various toxicity are done animal experiment, made the white mice medication 40 days, make the Liver and kidney slice probing, blood test, white, that erythrocyte there is no is variant with normal mice.See attached list 1, the patient who has takes Chinese patent medicine of the present invention half a year to more than a year, and the patient who has takes recover back several years of Chinese patent medicine of the present invention, more than ten years even decades, all finds no chronic poisoning or holds unusual reflection such as poison.

Clinical efficacy:

To treatment treatment of rheumatoid arthritis effect,, select 148 routine patients deeply and carefully to study, for verifying Chinese patent medicine of the present invention through modern science clinical trial more than 5 years with reference to the diagnostic criteria of U.S.'s rheumatoid arthritis in 1964.Clinical observation 500 examples are verified 133 examples.Confirm that Chinese patent medicine of the present invention has obvious, stable curative effect to rheumatoid arthritis.Effective percentage reaches 78.95%, remarkable treatment rate person nearly 30% is arranged, now will compare 15 routine RA with " benorilate ", observe, with Tripterygium hypoglaucum 20 routine RA are done retrospective reference, take Chinese patent drugs for treatment of the present invention rheumatoid 124 routine patients simultaneously and take the antirheumatic situation in the past and done the own control Retrospective review.

Usage and consumption: Chinese patent medicine of the present invention clothes every day once with the boiled water clothes, are the most handyly promptly slept after spilling clothes before sleeping.Do not wait according to patient's body constitution, the state of an illness, age difference, consumption.Begin after taking in a few days, to confirm no uncomfortable drug reaction from two or three (every 0.25g of Chinese patent medicine of the present invention) clothes; and the bigger efficacy of a drug person of bearing is arranged, can on former basis, increase by half, take a few days after; increase by half again, this day is obeyed 3～4, progressively increases to till 4～5.Four months is a course of treatment.

Result such as table 1,2,3

Table 1: medicine of the present invention dispels the wind red and the benorilate curative effect compares

Group	Observe routine number	Effectively						Invalid
										Produce effects		Take a turn for the better		Effectively
		Example	％	Example	％	Example	％									Example	％
								Observation group	133	39	29.32	66	49.63	105	78.95			28	21.05
Matched group	13	3	20.00	5	33.33	8	53.33									7	46.67

Table 2: medicine of the present invention dispels the wind red and the Tripterygium hypoglaucum curative effect compares

Group	Observe routine number	Effectively						Invalid
										Produce effects		Take a turn for the better		Effectively
		Example	％	Example	％	Example	％									Example	％
								Observation group	30	10	33.3	13	43.5	25	76.7			7	23.3
Matched group	20	1	5.0	8	40.0	9	45.0									11	55.0

Learn by statistics and handle P＜00.5

Table 3:124 example RA patient obeys medicine of the present invention and dispels the wind and take antirheumatic retrospective survey statistics before the pellet

Medicine	Observe routine number	Hormone		Benorylate		Tripterygium hypoglaucum		Aspirin		Indometacin		An Naijing		Piroxicam
																Example	％	Example	％	Example	％	Example	％	Example	％	Example	％	Example	％
			124	99	79.8	46	37.1	27	21.8	11	8.8	11	8.8	11	8.8															8	6.5

Medicine	Observe routine number	Effective rheumatism medicine		Ibuprofen		Antiflamison		Flufenamic acid		Azathioprine		Somedon
														Example	％	Example	％	Example	％	Example	％	Example	％	Example	％
			124	6	4.8	5	40.3	2	1.6	2	1.6	1	0.8													1	0.8

From table 1,2,3 find out that medicine of the present invention is better than benorilate, Tripterygium hypoglaucum to the therapeutic effect of rheumatoid arthritis, and the more stable spy of curative effect is of a specified duration.

Embodiment:

Take by weighing raw material by following proportioning: 10 kilograms of Semen Strychni, 4 kilograms of Radix Aconitis, 3 kilograms of Scolopendras.

Preparation method is as follows:

Earlier Semen Strychni is soaked in the urine of baby boys liquid, Semen Strychni adsorbs urine of baby boys liquid gradually.For guaranteeing that Semen Strychni fully adsorbs the weightening finish of urine of baby boys liquid to 1.5～2 times, soaked ten days summer according to practical experience, to soak winter 20 days, spring, a second season soaked 15 days.For keeping urine of baby boys liquid to never degenerate, change urine of baby boys liquid once every day in summer, and per 1 ,～3 days of winter changed once, and spring and autumn changed 1 time on the 1st～2.

Modern to be prepared as example summer: as earlier 10 kilograms of Semen Strychni to be soaked in the urine of baby boys liquid, to soak ten days, change urine of baby boys liquid every day once, after ten days, take out Semen Strychni, weigh 30 kilograms, clean with clear water, remove its fur floss, section, shine in, that processing powder is broken into 80 order fineness is standby; Claim 4 kilograms of Radix Aconitis, 0.2 thousand yuan in Semen phaseoli radiati, 0.2 kilogram in Radix Glycyrrhizae is put into pot and adds water logging and cross powder and boil, and simmers in water to the saturating heart again, and promptly Semen phaseoli radiati is boiled flower, takes out Radix Aconiti, puts into marmite with stir-fry stir-baking in sand shortcake.The cooling post-treatment becomes 80 order fineness standby; Claim that 3 kilograms of bakings of Scolopendra are crisp, it is standby to be processed into 80 order fineness.With the Semen Strychni Pulveratum after the processing, Radix Aconiti powder, Scolopendra powder mixing are made powder.

With above-mentioned powder and starch by compressed tablets behind 1: 1 the proportioning mixed pelletization.

Above-mentioned powder is incapsulated according to a conventional method, make capsule.

The clinical use result of Chinese patent medicine of the present invention shows that following advantage is arranged:

1, curative effect is preferably arranged, and curative effect is more stable lasting,

2, can replace benorilate, curative effect is better than benorilate, Tripterygium hypoglaucum,

3, safe and reliable, take for a long time and have no side effect.

Subordinate list 4: the medicine of the present invention red subacute experiment of dispeling the wind to rat---promptly to the influence of body weight, white elephant, liver, renal function

Grouping	Dosage Mg/kg	Body weight (g)		Antholeucin g%		Leukocyte (ten thousand/ul)		Erythrocyte 1,000,000/ul		Liver function GPTu/dl		Kidney merit (BuN) Mg/dl
														Before	After	Before	After	Before	After	Before	After	Before	After	Before	After
		Ⅰ	The equivalent ordinary water	119 ±7.6	211.7 ±7.7	13.7 ±0.27	13.8 ±0.25	1.56 ±0.15	1.48 ±0.12	7.35 ±0.23	6.97 ±0.23	39 ±6.3	48.3 ±6.7													13.5 ±1.6	14.5 ±0.75
Ⅱ	50													126 ±6.4	235.8 ±1.5	13.5 ±0.42	1.43 ±0.24	1.63 ±0.14	1.87 ±0.10	7.27 ±0.52	8.09 ±0.26	48 ±8.2	33.5 ±6.2	12.3 ±1.1	12.4 ±1.3
		Ⅲ	100	126 ±4.8	234.2 ±11.8	13.4 ±0.33	14.8 ±0.2	1.56 ±0.21	1.80 ±0.22	7.88 ±0.23	8.22 ±0.31	±3.1	34.5 ±6.1													11.1 ±2	10.4 ±0.8

Annotate: body weight, hemogram, liver, renal function numerical value are in the table: X ± SX

Claims (5)

1, the rheumatoid Chinese patent medicine of a kind of treatment is characterized in that its active ingredient is prepared from by following materials of weight proportions: 100 parts of Semen Strychni, 40 parts of Radix Aconitis, 30 parts of Scolopendras.

2, the preparation method of the rheumatoid Chinese patent medicine of a kind of treatment as claimed in claim 1, it is characterized in that Semen Strychni is soaked in the Freshman urine, and replacing remains freshly voided urine at any time, treat Semen Strychni soak increase weight to 1.5-2 doubly after, take out and clean, the peeling lint, cut into slices, dry, oil immersion is fried to crisp, is ground into 80 order fineness; Get Radix Aconiti, Semen phaseoli radiati, Radix Glycyrrhizae and go into pot and add and flooded powder and boil, the weight proportion of Radix Aconiti, Semen phaseoli radiati, Radix Glycyrrhizae is 10: 0.5: 0.5, simmers in water after boiling to the saturating heart, takes out Radix Aconiti fries extremely dried shortcake in hot sand after, is ground into 80 order fineness; The Scolopendra baking is crisp, is ground into 80 order fineness, with 10: 4: 3 by weight ratio ratio mixing of the Semen Strychni after the above-mentioned processing, Radix Aconiti, Scolopendra.

3, preparation method according to claim 2 is characterized in that said human urine is child's urine.

4, want root to ask 2 described preparation methoies according to right, it is characterized in that the powder stock of said mixing is made capsule routinely.

5, want root to ask 2 described preparation methoies according to right, it is characterized in that the powder stock of said mixing is made tablet routinely.