CN106109940A - A kind of Chinese medicine preparation treating nasopharyngeal carcinoma and preparation method - Google Patents
A kind of Chinese medicine preparation treating nasopharyngeal carcinoma and preparation method Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a kind of Chinese medicine preparation treating nasopharyngeal carcinoma and preparation method, belong to the field of Chinese medicines；The raw material of Chinese medicine preparation effective ingredient of the present invention consists of: Herba abutili indici, Thallus Porphyrae, Herba Andrographis, Radix Polygalae, Herba Selaginellae Doederleinii, Caulis Bambusae In Taeniam, Fructus Akebiae, Ganoderma applanatum (Pers. Ex Wallr) Pat., Caulis Marsdeniae Tenacissimae, Radix Luffae, Radix Glycyrrhizae, Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui), Hai Qian, Herba Astragali Bhotanensis, the Radix Angelicae Dahuricae and Herba goodyearae repentis；Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, all medicines are harmonious and have heat-clearing and toxic substances removing, anti-inflammatory and anticancer, promoting blood circulation and stopping pain, hard masses softening and resolving, relieving restlessness of nourishing heart, diuretic dehumidifying, profit effect such as nine orifices, the band courage and uprightness secretions that causes for treatment nasopharyngeal carcinoma, resorption tears blood, flaring of nares, in ear obturation sense, lingualis atrophy, the deflection that lolls, the metastasis of nasopharyngeal carcinoma, the symptom such as narrow, the palatine perforation of cavum nasopharyngeum have determined curative effect, instant effect, cure rate is high, have no side effect, safe and reliable advantage, can be widely applied to the clinical treatment of nasopharyngeal carcinoma.
Description
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating nasopharyngeal carcinoma and preparation method.
Background technology
Nasopharyngeal carcinoma refers to betide the malignant tumor of cavum nasopharyngeum top and sidewall.It is one of China's malignant tumor occurred frequently, sends out
Sick rate is first of ear,nose & throat malignant tumor.Common symptoms is band blood, ear suffocation sense, auditory dysesthesia, diplopia in nasal obstruction, tears
And headache etc..The big multipair radiotherapy of nasopharyngeal carcinoma has Medium sensitivity, and radiotherapy is the first-selected Therapeutic Method of nasopharyngeal carcinoma.But
To relatively well-differentiated carcinoma, the course of disease is later and the case of recurrence after radiotherapy, excision and chemotherapy also belong to can not
The means lacked.
Nasopharyngeal carcinoma morbidity can cause ear's health of patient by serious harm, it is generally the case that Nasopharyngeal Carcinoma Patients
Tinnitus, auditory dysesthesia, in ear obturation sense, nasopharyngeal carcinoma occurs when nasopharynx sidewall, side nest or pharyngotympanic tube opening upper lip, oncothlipsis
Pharyngotympanic tube can occur Unilateral tinnitus or auditory dysesthesia, and catarrhal otitis media also can occur.Unilateral tinnitus or auditory dysesthesia, ear
Interior inaccessible sense broadly falls into the Symptoms of nasopharyngeal carcinoma.
During morbidity, Nasopharyngeal Carcinoma Patients can produce the symptom of headache, and this symptom can run through the whole of patient substantially
The course of disease.The one that headache is relatively common in the symptom for nasopharyngeal carcinoma, accounts for 68.6%.Headache position is not fixed in early days, intermittent.After
Phase headache is persistence, and is difficult to pain relieving, causes patient to endure to the fullest extent and decocts.
Resorption tears blood is the typical health hazard that patient is to be born, and is also typical case's morbidity performance at initial stage,
If able to treat in time, the rehabilitation of patient is on the make.The harm of nasopharyngeal carcinoma also has inhales sputum mixed with blood or blowing the nose after nose
Time tears in band blood.In early days apoplexy due to phlegm or tears only have a small amount of blood streak, cut in and out.Monitor is more, can have nose bleeding.
Mostly the at present treatment for assertive evidence is to use western medicine, but also exist that patient is big to drug dependence, medicine is to trouble
The organ of person has the problems such as certain toxic and side effects.To this end, we are badly in need of developing the Chinese medicine preparation that a kind of safety has no side effect
Patient is helped to break away from the misery that nasopharyngeal carcinoma is brought.
Summary of the invention
The invention provides a kind of Chinese medicine preparation treating nasopharyngeal carcinoma and preparation method；Medical material selected by Chinese medicine preparation of the present invention
Compatibility is suitable, and all medicines are harmonious and have heat-clearing and toxic substances removing, anti-inflammatory and anticancer, promoting blood circulation and stopping pain, hard masses softening and resolving, relieving restlessness of nourishing heart, diuretic dehumidifying, profit
The effects such as nine orifices, the band courage and uprightness secretions caused for treatment nasopharyngeal carcinoma, resorption tears blood, flaring of nares, in ear obturation sense, lingualis wither
The symptoms such as contracting, narrow, the palatine perforation of the deflection that lolls, the metastasis of nasopharyngeal carcinoma, cavum nasopharyngeum have determined curative effect, instant effect, control
More rate is high, have no side effect, safe and reliable advantage, can be widely applied to the clinical treatment of nasopharyngeal carcinoma.
For achieving the above object, technical scheme is implemented as follows:
A kind of Chinese medicine preparation treating nasopharyngeal carcinoma, makes raw material composition and the parts by weight of described Chinese medicine preparation effective ingredient
For:
Herba abutili indici 62-86 part Thallus Porphyrae 57-81 part Herba Andrographis 57-81 part Radix Polygalae 52-76 part
Herba Selaginellae Doederleinii 47-71 part Caulis Bambusae In Taeniam 47-71 part Fructus Akebiae 42-62 part Ganoderma applanatum (Pers. Ex Wallr) Pat. 42-62 part
Caulis Marsdeniae Tenacissimae 37-57 part Radix Luffae 32-52 part Radix Glycyrrhizae 32-52 part Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) 27-47 part
The alizarin 20-40 part Herba Astragali Bhotanensis 20-40 part Radix Angelicae Dahuricae 17-37 part Herba goodyearae repentis 15-37 part in sea.
Make described Chinese medicine preparation effective ingredient raw material composition and parts by weight be:
80 portions of Thallus Porphyraes of Herba abutili indici, 75 parts of Radix Polygalaes of 75 parts of Herba Andrographis 70 parts
65 parts of Caulis Bambusae In Taeniam of Herba Selaginellae Doederleinii, 57 parts of Ganoderma applanatum (Pers. Ex Wallr) Pat.s of 65 parts of Fructus Akebiaes 57 parts
52 parts of Radix Luffae of Caulis Marsdeniae Tenacissimae, 47 parts of Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) of 47 portions of Radix Glycyrrhizaes 42 parts
Alizarin 34 parts of Herba Astragali Bhotanensiss, the 31 parts of Herba goodyearae repentis of 34 parts of Radixs Angelicae Dahuricae 31 parts in sea.
Make described Chinese medicine preparation effective ingredient raw material composition and parts by weight be:
74 portions of Thallus Porphyraes of Herba abutili indici, 69 parts of Radix Polygalaes of 69 parts of Herba Andrographis 64 parts
59 parts of Caulis Bambusae In Taeniam of Herba Selaginellae Doederleinii, 52 parts of Ganoderma applanatum (Pers. Ex Wallr) Pat.s of 59 parts of Fructus Akebiaes 52 parts
47 parts of Radix Luffae of Caulis Marsdeniae Tenacissimae, 42 parts of Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) of 42 portions of Radix Glycyrrhizaes 37 parts
Alizarin 30 parts of Herba Astragali Bhotanensiss, the 27 parts of Herba goodyearae repentis of 30 parts of Radixs Angelicae Dahuricae 27 parts in sea.
Make described Chinese medicine preparation effective ingredient raw material composition and parts by weight be:
68 portions of Thallus Porphyraes of Herba abutili indici, 63 parts of Radix Polygalaes of 63 parts of Herba Andrographis 58 parts
53 parts of Caulis Bambusae In Taeniam of Herba Selaginellae Doederleinii, 47 parts of Ganoderma applanatum (Pers. Ex Wallr) Pat.s of 53 parts of Fructus Akebiaes 47 parts
42 parts of Radix Luffae of Caulis Marsdeniae Tenacissimae, 37 parts of Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) of 37 portions of Radix Glycyrrhizaes 32 parts
Alizarin 25 parts of Herba Astragali Bhotanensiss, the 22 parts of Herba goodyearae repentis of 25 parts of Radixs Angelicae Dahuricae 22 parts in sea.
The preparation method of a kind of Chinese medicine preparation treating nasopharyngeal carcinoma, comprises the following steps that:
(1) Herba abutili indici, Thallus Porphyrae, Herba Andrographis, Herba Selaginellae Doederleinii, Caulis Bambusae In Taeniam, Radix Luffae, Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui), Herba Astragali Bhotanensis and the Radix Angelicae Dahuricae are put into appearance
In device, add 10 times amount distilled water immersion after 4 hours, heated and boiled 4 hours, extract；Second time adds 8 times amount distilled water heating
Boil 3 hours, extract；Third time adds 6 times amount distilled water heated and boiled 2 hours, extracts；Merge three gained extracting solution, filter
Cross, obtain filtrate standby；
(2) Radix Polygalae, Fructus Akebiae, Ganoderma applanatum (Pers. Ex Wallr) Pat., Hai Qian and Herba goodyearae repentis are put in container, immerse 10 times amount volumetric concentration 70% second
Alcoholic solution soaks 4 hours, heating extraction, filters, and after standing, reclaims ethanol and to be concentrated into 60 DEG C of relative densities be 1.12-1.15
Thick paste standby；
(3) by the vinegar liquid of Caulis Marsdeniae Tenacissimae 3 times of volumes of immersion 2-3 hour, taking out and clean, drying is ground into powder, obtains 120 purposes
Fine powder, standby；
(4) Radix Glycyrrhizae is soaked in water to eighty per cant thoroughly time, pull out, run through section, dry, grind into powder, obtained 180 purposes thin
Powder, standby；
(5) filtrate obtained by above-mentioned steps (1)-(4), thick paste and fine powder are mixed, make granule, be described controlling
Treat the Chinese medicine preparation of nasopharyngeal carcinoma.
The property of medicine of Chinese medicine used by the present invention is as follows:
Herba abutili indici: sweet in the mouth, light, cool in nature；Return lung, kidney channel.Wind and heat dispersing, preventing phlegm from forming and stopping coughing, subduing swelling and detoxicating.Main flu, heating,
Cough, has loose bowels, otitis media, deaf, pharyngitis, parotitis, urinary tract infection, sore and toxic, traumatic injury." south of the Five Ridges gather medicinal herbs record " carries:
" energy ascending the clear and descending the turbid, has one's ideas straightened out and invigorates blood circulation, and saves again and broadcasts hands, ulcerative carbuncle.”
Thallus Porphyrae: sweet in the mouth, salty, cold in nature；Return lung, spleen, bladder warp.Resolving phlegm and softening hard masses, sore-throat relieving, cough-relieving, relieving restlessness of nourishing heart, diuretic removes
Wet.Main goiter, tinea pedis, edema, laryngopharynx swelling and pain, cough, irritated insomnia, urine leaching pain, dysentery." with earnestly occupying diet spectrum " carries: " with
Blood nourishes heart, and is tired of clearly and washs heat, controls and be insomnia, throat, and except tinea pedis goiter, row dysentery time main, analysis is waken up and whetted the appetite.”
Herba Andrographis: bitter in the mouth, cold in nature；GUIXIN, lung, large intestine, bladder warp.Heat-clearing and toxic substances removing, pathogenic fire purging, dampness.Main anemopyretic cold, temperature
Sick heating, cough due to lung-heat, pertussis, lung abscess, laryngopharynx swelling and pain, jaundice due to damp-heat, stranguria, erysipelas, skin infection carbuncle, eczema, poisonous snake stings
Wound." Quanzhou book on Chinese herbal medicine " carries: " heat-clearing and toxic substances removing, antiinflammatory detumescent.Control laryngopharyngitis, dysentery, high heat.”
Radix Polygalae: acrid in the mouth, hardship, slightly warm in nature；GUIXIN, liver,spleen,kidney warp.Mind tranquilizing and the heart calming, eliminates the phlegm and has one's ideas straightened out, removing toxic substances and promoting subsidence of swelling.The main mind
Uneasiness, palpitation with fear insomnia, forgetful, infantile convulsion, cough with copious phlegm, carbuncle carbuncle on the back, breast swell and pain.Shennong's Herbal carries: " main cough with dyspnea is hindered
In, tonifying for the deficiency, evil removing gas, profit nine orifices, Fructus Alpiniae Oxyphyllae is intelligent, and normal hearing and eyesight is not forgotten, strong will times power.”
Herba Selaginellae Doederleinii: sweet in the mouth, micro-hardship, puckery, cool in nature.Heat-clearing and toxic substances removing, expelling wind and removing dampness.Main laryngopharynx swelling and pain, conjunctival congestion and swelling pain, lung-heat is coughed
Cough, mastitis, jaundice due to damp-heat, rheumatic arthralgia, traumatic hemorrhage.
Caulis Bambusae In Taeniam: sweet in the mouth, micro-hardship, cool in nature.Boosting qi and nourishing yin, nourishing the lung to arrest cough, clearing away heat-damp and promoting diuresis.Main deficiency of the lung heat syndrome cough, laryngitis, dysentery,
Leucorrhea, hypertension, hyperlipemia, antineoplastic auxiliary treatment, typically support food.
Fructus Akebiae: mildly bitter flavor, property is put down；Return liver, stomach, bladder warp.Dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.
Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, diet not to disappear, dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, dislike
Property tumor." pharmacognosy " carries: " promoting the circulation of QI, invigorates blood circulation, parasite killing, removing toxic substances, pain relieving.For diseases such as stomachache due to hyperactive liver-QI attacking the stomach, hypochondriac pain, menstrual pain.”
Ganoderma applanatum (Pers. Ex Wallr) Pat.: mildly bitter flavor, property is put down；Return spleen, stomach warp.Anti-inflammatory and anticancer.Main pharyngolaryngitis, the esophageal carcinoma, nasopharyngeal carcinoma." China is medicinal
Fungus " carry: " there is active anticancer.For diseases such as treatment of esophagus cancer.”
Caulis Marsdeniae Tenacissimae: bitter in the mouth, cold nature；Return lung, Liver Channel.Heat-clearing and toxic substances removing, relieving cough and asthma, the wet lactogenesis of tonneau, anticancer.Main throat
Swell and ache, lung-heat cough with asthma, jaundice due to damp-heat, dysuria, galactostasis, furuncle, cancerous protuberance." choosing of Yunnan Chinese herbal medicine " carries: " antiinflammatory, only
Cough, relieving asthma, anticancer.Control bronchitis, bronchial asthma, various cancers, rheumatism, traumatic injury, fracture, optical fundus illness, gastropathy.”
Radix Luffae: sweet in the mouth, micro-hardship, cold in nature.Promoting blood circulation to remove obstruction in the collateral, heat-clearing and toxic substances removing.Main migraine, lumbago, arthromyodynia, mastitis, nose
Inflammation, sinusitis, acute throat trouble swells and ache, discharging fresh blood stool, anal fistula." Chongqing medical herbs " carries: " the meridian dredging, promoting the circulation of blood, subside a swelling swollen, stimulating milk secretion.Control breast
Swell and ache, back distending pain.”
Radix Glycyrrhizae: sweet in the mouth, property is put down；Return spleen, stomach, the heart, lung meridian.QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, adjust
With all medicines.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, loose stool of suffering from abdominal pain, extremity contraction urgency pain, hysteria, cough and asthma, throat
Swelling and ache, ulcerative carbuncle swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.Modern medicine study confirms, Radix Glycyrrhizae has antitumor action.
Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui): bitter in the mouth, pungent, cool in nature.Heat-clearing and toxic substances removing.Main air fire acute conjunctivitis, rhinitis, laryngopharynx swelling and pain, bronchitis, furuncle swells
Bitterly." Xinhua's book on Chinese herbal medicine outline " carries: " young stem and leaf: have the function (making vegetable to eat) of heat-clearing and toxic substances removing, improving eyesight.”
Hai Qian: salty in the mouth, cold in nature；Return liver, stomach, kidney channel.Hard masses softening and resolving, removing heat-phlegm, diuretic.Main scrofula, goiter, swelling throat
Bitterly, cough expectorant knot, dysuria, edema, furuncle, angina pectoris, iodine deficiency endemic goiter, hypertension, hyperlipidemia.Existing
Confirming for medical research, Hai Qian has antitumor action.
Herba Astragali Bhotanensis: bitter in the mouth, puckery, cool in nature；Return liver, kidney channel.Heat-clearing and toxic substances removing, diuresis antidiarrheal.Main laryngopharynx swelling and pain, cough, measles,
Edema, has loose bowels, and dysentery is had a toothache, and mouth and nose are hemorrhage.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature；Return lung, spleen, stomach warp.Expelling wind and removing dampness, logical surreptitiously pain relieving, detumescence and apocenosis.Main headache due to common cold, eyebrow
Rib osteodynia, toothache, nasal obstruction, nasal sinusitis, domination of damp pathogen chronic diarrhea, women leucorrhea, ulcer sores, venom." Japan hanako materia medica " carries: " control
Conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood, benefit fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies,
Pain relieving granulation promoting, goes slope, face defect scar.”
Herba goodyearae repentis: sweet in the mouth, pungent, property is put down.Nourishing the lung to arrest cough, tonifies Qi of the kidney, promoting flow of QI and blood, subduing swelling and detoxicating.Main pulmonary tuberculosis cough, gas
Guan Yan, dizzy weak, neurasthenia, sexual impotence, traumatic injury, arthralgia, laryngopharynx swelling and pain, acute mastitis, furuncle, scrofula, poisonous snake stings
Wound." Zhejiang conventional medical herbs among the people " carries: " heat-clearing and toxic substances removing, antiinflammatory detumescent.Controlling venom, carbuncle furuncle, pneumonopathy is coughed, trachea
Scorching.”
The present invention compared with prior art, has the advantages that
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, and all medicines are harmonious and have heat-clearing and toxic substances removing, anti-inflammatory and anticancer, only invigorate blood circulation
Bitterly, hard masses softening and resolving, relieving restlessness of nourishing heart, diuretic dehumidifying, profit effect such as nine orifices, the band courage and uprightness secretions that treatment nasopharyngeal carcinoma is caused,
Resorption tears blood, flaring of nares, in ear obturation sense, lingualis atrophy, the deflection that lolls, the metastasis of nasopharyngeal carcinoma, cavum nasopharyngeum are narrow, palatine
The symptoms such as perforation have determined curative effect, instant effect, cure rate is high, have no side effect, safe and reliable advantage, can be widely applied to
The clinical treatment of nasopharyngeal carcinoma.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Herba abutili indici 84g Thallus Porphyrae 79g Herba Andrographis 79g Radix Polygalae 75g
Herba Selaginellae Doederleinii 69g Caulis Bambusae In Taeniam 69g Fructus Akebiae 60g Ganoderma applanatum (Pers. Ex Wallr) Pat. 60g
Caulis Marsdeniae Tenacissimae 55g Radix Luffae 50g Radix Glycyrrhizae 50g Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) 45g
The alizarin 38g Herba Astragali Bhotanensis 38g Radix Angelicae Dahuricae 35g Herba goodyearae repentis 35g in sea.
The preparation method of a kind of Chinese medicine preparation treating nasopharyngeal carcinoma, comprises the following steps that:
(1) Herba abutili indici, Thallus Porphyrae, Herba Andrographis, Herba Selaginellae Doederleinii, Caulis Bambusae In Taeniam, Radix Luffae, Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui), Herba Astragali Bhotanensis and the Radix Angelicae Dahuricae are put into appearance
In device, add 10 times amount distilled water immersion after 4 hours, heated and boiled 4 hours, extract；Second time adds 8 times amount distilled water heating
Boil 3 hours, extract；Third time adds 6 times amount distilled water heated and boiled 2 hours, extracts；Merge three gained extracting solution, filter
Cross, obtain filtrate standby；
(2) Radix Polygalae, Fructus Akebiae, Ganoderma applanatum (Pers. Ex Wallr) Pat., Hai Qian and Herba goodyearae repentis are put in container, immerse 10 times amount volumetric concentration 70% second
Alcoholic solution soaks 4 hours, heating extraction, filters, and after standing, reclaims ethanol and to be concentrated into 60 DEG C of relative densities be 1.12-1.15
Thick paste standby；
(3) by the vinegar liquid of Caulis Marsdeniae Tenacissimae 3 times of volumes of immersion 2-3 hour, taking out and clean, drying is ground into powder, obtains 120 purposes
Fine powder, standby；
(4) Radix Glycyrrhizae is soaked in water to eighty per cant thoroughly time, pull out, run through section, dry, grind into powder, obtained 180 purposes thin
Powder, standby；
(5) filtrate obtained by above-mentioned steps (1)-(4), thick paste and fine powder are mixed, make granule, be described controlling
Treat the Chinese medicine preparation of nasopharyngeal carcinoma.
Usage and dosage: oral, warm boiled water after meal, every day 2 times, the most each 1 time, each 2 bags (every bag of 15g)；15 days
Being 1 course for the treatment of, 2 courses for the treatment of of the lighter, severe one 3-5 can be fully recovered the course for the treatment of.
Embodiment 2
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Herba abutili indici 80g Thallus Porphyrae 75g Herba Andrographis 75g Radix Polygalae 70g
Herba Selaginellae Doederleinii 65g Caulis Bambusae In Taeniam 65g Fructus Akebiae 57g Ganoderma applanatum (Pers. Ex Wallr) Pat. 57g
Caulis Marsdeniae Tenacissimae 52g Radix Luffae 47g Radix Glycyrrhizae 47g Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) 42g
The alizarin 34g Herba Astragali Bhotanensis 34g Radix Angelicae Dahuricae 31g Herba goodyearae repentis 31g in sea.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 3
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Herba abutili indici 74g Thallus Porphyrae 69g Herba Andrographis 69g Radix Polygalae 64g
Herba Selaginellae Doederleinii 59g Caulis Bambusae In Taeniam 59g Fructus Akebiae 52g Ganoderma applanatum (Pers. Ex Wallr) Pat. 52g
Caulis Marsdeniae Tenacissimae 47g Radix Luffae 42g Radix Glycyrrhizae 42g Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) 37g
The alizarin 30g Herba Astragali Bhotanensis 30g Radix Angelicae Dahuricae 27g Herba goodyearae repentis 27g in sea.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 4
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Herba abutili indici 68g Thallus Porphyrae 63g Herba Andrographis 63g Radix Polygalae 58g
Herba Selaginellae Doederleinii 53g Caulis Bambusae In Taeniam 53g Fructus Akebiae 47g Ganoderma applanatum (Pers. Ex Wallr) Pat. 47g
Caulis Marsdeniae Tenacissimae 42g Radix Luffae 37g Radix Glycyrrhizae 37g Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) 32g
The alizarin 25g Herba Astragali Bhotanensis 25g Radix Angelicae Dahuricae 22g Herba goodyearae repentis 22g in sea.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Clinical data:
1, case selection:
Selecting the Nasopharyngeal Carcinoma Patients 240 example clinical observation made a definite diagnosis, patient is randomly divided into treatment group and matched group two groups, treatment
Organize 120 examples, wherein male 60 example, women 60 example, age 21-70 year, 43.3 years old mean age, course of disease 1-5.Matched group 120
Example, wherein male 60 example, women 60 example, age 21-70 year, 43.1 years old mean age, course of disease 1-5.Treatment group and matched group
The course of disease of two groups of cases, degrees of symptoms are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes Chinese medicine preparation of the present invention, oral, warm boiled water after meal, every day 2 times, the most each 1 time, and each 2
Bag (every bag of 15g)；Within 15 days, it is 1 course for the treatment of, 2 courses for the treatment of of the lighter, severe one 3-5 course for the treatment of.
Matched group takes XIAOAIPING PIAN, by specification use, or follows the doctor's advice and take.
3, efficacy determination:
(1) cure: band courage and uprightness secretions, resorption tears blood, flaring of nares, in ear obturation sense, lingualis atrophy, the deflection that lolls, nose
The transference cures such as the metastasis of pharyngeal cancer, cavum nasopharyngeum are narrow, palatine perforation, physical recovery is normal.
(2) effective: above-mentioned symptom has been alleviated, gastric motility has recovered.
(3) invalid: by symptom after treatment without being clearly better.
4, result:
Selecting in the treatment group of Chinese medicine preparation of the present invention, cure 85 examples, take a turn for the better 32 examples, invalid 3 examples, cure rate 70.8%,
Total effective rate 97.5%.
Curing 36 examples, effective 31 examples in matched group, take a turn for the better 53 examples, cure rate 30%, total effective rate 55.8%.
Result above shows, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Shen, man, 66 years old, retired cadre, Dongguan, Guangdong people.There is auris dextra vexed plug sense without obvious inducement before 3 years in patient,
Gradually auditory dysesthesia, the intermittent tinnitus of companion, diagnose at local hospital: secretory otitis media, parallel auripuncture drawing liquid, but patient's disease
Shape still recurrent exerbation, nasal endoscopy finds nasopharynx part neoplasm.Take 2 courses for the treatment of of Chinese medicine preparation of the present invention, above-mentioned disease
Shape substantially alleviates；Continuing to take 1 course for the treatment of of Chinese medicine preparation of the present invention, above-mentioned symptom thoroughly disappears, and follows up a case by regular visits to, without recurrence, thoroughly control
More.
2, grandson, female, 55 years old, teacher, people from Hefei ,Anhui.It is ambiguous that patient occurs speaking without obvious inducement, and pharyngeal have
Foreign body sensation, local hospital inspection: show no obvious abnormalities.The rear patient left neck that stumbles on swells thing, the most to our hospital, through inspection
Look into and be diagnosed as nasopharyngeal carcinoma.Taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, above-mentioned symptom substantially alleviates；Continue to take the present invention
2 courses for the treatment of of Chinese medicine preparation, above-mentioned symptom thoroughly disappears, and follows up a case by regular visits to, without recurrence, thoroughly cure.
3, certain is tried to gain, man, 49 years old, manager, people from Shijiazhuang, Hebei.There is the rightest epistaxis without obvious inducement in patient, every time
Amount is few, can be from only.Rear suction nose has band blood in tears, to our hospital, is diagnosed as nasopharyngeal carcinoma on inspection, gives multi-medicament equal nothing
Obvious curative effects.After take 1 course for the treatment of of Chinese medicine preparation of the present invention, above-mentioned symptom substantially alleviates；Continue to take Chinese medicine of the present invention
2 courses for the treatment of of preparation, above-mentioned symptom thoroughly disappears, and follows up a case by regular visits to, without recurrence, thoroughly cure.
4, Zhai, female, 45 years old, civil servant, Heze City, Shandong Province people.Patient without obvious inducement occur nasal obstruction, stream the yellow thick nasal discharge band blood streak,
The symptoms such as headache, used several drugs to treat, and effect is undesirable.The most to our hospital, it is diagnosed as nasopharyngeal carcinoma on inspection.Take
With 1 course for the treatment of of Chinese medicine preparation of the present invention, above-mentioned symptom substantially alleviates；After continuing to take 2 courses for the treatment of of Chinese medicine preparation of the present invention, above-mentioned
Symptom thoroughly disappears, and follows up a case by regular visits to, without recurrence, thoroughly cure.
5, Liu, man, 33 years old, accounting, Henan flat-top recluse.There is nasal obstruction, watery nasal discharge band blood without obvious inducement before 2 years in patient
The symptoms such as silk, headache.The most to our hospital, it is diagnosed as nasopharyngeal carcinoma on inspection.Take 1 course for the treatment of of Chinese medicine preparation of the present invention
After, above-mentioned symptom substantially alleviates, and after continuing to take 2 courses for the treatment of of Chinese medicine preparation of the present invention, physical recovery is normal.
6, what certain, female, 26 years old, service man, people from Yingkou, Liaoning.There are resorption blood tears without obvious inducement before 2 years in patient, was working as
Clinic, ground does not takes an evident turn for the better after giving Drug therapy.The most to our hospital, it is diagnosed as nasopharyngeal carcinoma on inspection.Take this
2 courses for the treatment of of bright Chinese medicine preparation, above-mentioned symptom substantially alleviates；Continuing to take 2 courses for the treatment of of Chinese medicine preparation of the present invention, above-mentioned symptom is thorough
Disappear, follow up a case by regular visits to, without recurrence, thoroughly cure.
Claims (5)
1. the Chinese medicine preparation treating nasopharyngeal carcinoma, it is characterised in that: make the raw material composition of described Chinese medicine preparation effective ingredient
And parts by weight are:
Herba abutili indici 62-86 part Thallus Porphyrae 57-81 part Herba Andrographis 57-81 part Radix Polygalae 52-76 part
Herba Selaginellae Doederleinii 47-71 part Caulis Bambusae In Taeniam 47-71 part Fructus Akebiae 42-62 part Ganoderma applanatum (Pers. Ex Wallr) Pat. 42-62 part
Caulis Marsdeniae Tenacissimae 37-57 part Radix Luffae 32-52 part Radix Glycyrrhizae 32-52 part Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) 27-47 part
The alizarin 20-40 part Herba Astragali Bhotanensis 20-40 part Radix Angelicae Dahuricae 17-37 part Herba goodyearae repentis 15-37 part in sea.
A kind of Chinese medicine preparation treating nasopharyngeal carcinoma the most according to claim 1, it is characterised in that: make described Chinese medicine preparation
The raw material of effective ingredient forms and parts by weight are:
80 portions of Thallus Porphyraes of Herba abutili indici, 75 parts of Radix Polygalaes of 75 parts of Herba Andrographis 70 parts
65 parts of Caulis Bambusae In Taeniam of Herba Selaginellae Doederleinii, 57 parts of Ganoderma applanatum (Pers. Ex Wallr) Pat.s of 65 parts of Fructus Akebiaes 57 parts
52 parts of Radix Luffae of Caulis Marsdeniae Tenacissimae, 47 parts of Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) of 47 portions of Radix Glycyrrhizaes 42 parts
Alizarin 34 parts of Herba Astragali Bhotanensiss, the 31 parts of Herba goodyearae repentis of 34 parts of Radixs Angelicae Dahuricae 31 parts in sea.
A kind of Chinese medicine preparation treating nasopharyngeal carcinoma the most according to claim 1, it is characterised in that: make described Chinese medicine preparation
The raw material of effective ingredient forms and parts by weight are:
74 portions of Thallus Porphyraes of Herba abutili indici, 69 parts of Radix Polygalaes of 69 parts of Herba Andrographis 64 parts
59 parts of Caulis Bambusae In Taeniam of Herba Selaginellae Doederleinii, 52 parts of Ganoderma applanatum (Pers. Ex Wallr) Pat.s of 59 parts of Fructus Akebiaes 52 parts
47 parts of Radix Luffae of Caulis Marsdeniae Tenacissimae, 42 parts of Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) of 42 portions of Radix Glycyrrhizaes 37 parts
Alizarin 30 parts of Herba Astragali Bhotanensiss, the 27 parts of Herba goodyearae repentis of 30 parts of Radixs Angelicae Dahuricae 27 parts in sea.
A kind of Chinese medicine preparation treating nasopharyngeal carcinoma the most according to claim 1, it is characterised in that: make described Chinese medicine preparation
The raw material of effective ingredient forms and parts by weight are:
68 portions of Thallus Porphyraes of Herba abutili indici, 63 parts of Radix Polygalaes of 63 parts of Herba Andrographis 58 parts
53 parts of Caulis Bambusae In Taeniam of Herba Selaginellae Doederleinii, 47 parts of Ganoderma applanatum (Pers. Ex Wallr) Pat.s of 53 parts of Fructus Akebiaes 47 parts
42 parts of Radix Luffae of Caulis Marsdeniae Tenacissimae, 37 parts of Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui) of 37 portions of Radix Glycyrrhizaes 32 parts
Alizarin 25 parts of Herba Astragali Bhotanensiss, the 22 parts of Herba goodyearae repentis of 25 parts of Radixs Angelicae Dahuricae 22 parts in sea.
5. the preparation method of the Chinese medicine preparation treating nasopharyngeal carcinoma as described in any one of claim 1-4, it is characterised in that: bag
Include following processing step:
(1) Herba abutili indici, Thallus Porphyrae, Herba Andrographis, Herba Selaginellae Doederleinii, Caulis Bambusae In Taeniam, Radix Luffae, Dendranthemia capitata (Wall.) hutch. Hand (-Mazz.) X. D. Cui), Herba Astragali Bhotanensis and the Radix Angelicae Dahuricae are put in container,
Add 10 times amount distilled water immersion after 4 hours, heated and boiled 4 hours, extract；Second time adds 8 times amount distilled water heated and boiled 3
Hour, extract；Third time adds 6 times amount distilled water heated and boiled 2 hours, extracts；Merge three gained extracting solution, filter,
Filtrate is standby；
(2) Radix Polygalae, Fructus Akebiae, Ganoderma applanatum (Pers. Ex Wallr) Pat., Hai Qian and Herba goodyearae repentis are put in container, immerse 10 times amount volumetric concentration 70% ethanol molten
Immersion is steeped 4 hours, heating extraction, filters, and after standing, reclaims ethanol and to be concentrated into 60 DEG C of relative densities be the thick of 1.12-1.15
Cream is standby；
(3) by the vinegar liquid of Caulis Marsdeniae Tenacissimae 3 times of volumes of immersion 2-3 hour, taking out and clean, drying is ground into powder, obtains 120 purposes thin
Powder, standby；
(4) Radix Glycyrrhizae is soaked in water to eighty per cant thoroughly time, pull out, run through section, dry, grind into powder, obtained the fine powder of 180 mesh, standby
With；
(5) filtrate obtained by above-mentioned steps (1)-(4), thick paste and fine powder are mixed, make granule, be described treatment nose
The Chinese medicine preparation of pharyngeal cancer.
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| CN106924616A (en) * | 2017-05-22 | 2017-07-07 | 何东良 | A kind of Chinese medicine composition and its preparation for treating nasopharyngeal carcinoma |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055155A (en) * | 2012-12-26 | 2013-04-24 | 柳州市中医院 | Traditional Chinese medicine for treating nasopharyngeal carcinoma and preparation method thereof |
| CN103977195A (en) * | 2014-05-29 | 2014-08-13 | 邱小燕 | Pharmaceutical composition for treating nasopharynx cancer |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103055155A (en) * | 2012-12-26 | 2013-04-24 | 柳州市中医院 | Traditional Chinese medicine for treating nasopharyngeal carcinoma and preparation method thereof |
| CN103977195A (en) * | 2014-05-29 | 2014-08-13 | 邱小燕 | Pharmaceutical composition for treating nasopharynx cancer |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924616A (en) * | 2017-05-22 | 2017-07-07 | 何东良 | A kind of Chinese medicine composition and its preparation for treating nasopharyngeal carcinoma |
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Application publication date: 20161116 |