CN106109641A - A kind of Chinese medicinal capsule treating sterility and infertility and preparation method thereof - Google Patents
A kind of Chinese medicinal capsule treating sterility and infertility and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicinal capsule treating sterility and infertility, belong to technical field of Chinese medicines.Inventor is in clinical practice for many years, according to the cause of disease of sterility and infertility, according to the theory of Chinese medical science of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, select Chinese medicine Radix Rosae Sertatae, Folium Ledi Angusti, Herba Viviae Sativae, Herba Limoii Bicoloris, Radix Buddlejae Butterflybush, Herba Galii Teneri, Heraba Moslae Diantherae, Radix Gomphostemmae, make Chinese medicinal capsule, through clinical trial, evident in efficacy.Particularly to suffering from the patient of hypertension simultaneously, also having good therapeutical effect, can yet be regarded as is the good recipe of a treatment hypertension.
Description
Technical field
The invention belongs to pharmaceutical technology field, particularly to a kind of Chinese medicinal capsule treating sterility and infertility and preparation side thereof
Method.
Background technology
The women of child-bearing age owing to suffering from a deficiency of the kidney, the reason such as stagnation of liver-QI, phlegm-damp, blood stasis, cause punching to be appointed, dysfunctional uterine, marry 2 years
Above, or once breeding latter more than 2 years, matrimonial cohabitation, syngamy function is normal, and the person that do not becomes pregnant, referred to as infertility.People
The understanding of infertile reason and treatment be may often be such that unilateral the most incorrect, this not only adds many Infertile couples
Worry, more allows many patients by the fear to infertile treatment therefore occur and being full of self-accusation, has had a strong impact on work and life.Lead
The reason causing infertility is a lot.Never pregnancy person is primary infertility, once has fertility or without contraception 2 years post-abortion
The most infertile person is secondary infertility.Infertility sickness rate is 5%-10%, for one of common difficult treatment of gynecological.This disease occurs
Reason more, predominantly genital lesion, such as ovulation failure, fallopian tube impatency, endometriosis etc..If it is geneogenous
Physiological defect such as ametria, anovarism, ametria inner membrance, substantive uterus and substantive fallopian tube etc., then non-drug can solve
Certainly, modern Western medicine treatment primary disease is without specific drugs, and through the therapy frequently with injection hormone pin, its therapeutic effect is undesirable, also can
Cause female body to damage, be unfavorable for that women keeps normal physiological health.In the treatment to infertility of China's traditional Chinese medical science, have
The history of more than 2000 year, have accumulated substantial amounts of clinical experience and theoretical basis, and the medium-height grass the effective elements of the medicine used enters machine
After body, by different histiocyte selective uses, and participate in the metabolism of health, be nearly free from toxic and side effects.Along with
The development of modern medical diagnosis technology, this disease of Chinese traditional treatment dialectical be combined with differential diagnosis of diseases and the aspect such as Artificial menstrual cycle with Chinese herbal medicine therapy all
There is impressive progress.
Summary of the invention
Present invention aim to address the deficiencies in the prior art, it is provided that a kind of Chinese medicinal capsule treating sterility and infertility and
Preparation method.According to theory of Chinese medical science, this disease controls suitable warming the meridian and activating blood circulation, dispersing cold for relieving pain, and blood stasis dispelling stimulates the menstrual flow, spleen invigorating mind calming, invigorating the spleen and replenishing QI, supports
Blood and tranquilizing mind is main.
The Chinese medicinal capsule for the treatment of sterility and infertility of the present invention is made up of the crude drug of following weight portion: Radix Rosae Sertatae
120-160 part, Folium Ledi Angusti 30-40 part, Herba Viviae Sativae 80-100 part, Herba Limoii Bicoloris 90-100 part, Radix Buddlejae Butterflybush 8-16 part, Herba Galii Teneri
18-30 part, Heraba Moslae Diantherae 15-21 part, Radix Gomphostemmae 30-40 part.
Preferred: Radix Rosae Sertatae 140 parts, Folium Ledi Angusti 35 parts, Herba Viviae Sativae 90 parts, Herba Limoii Bicoloris 95 parts, Radix Buddlejae Butterflybush 12 parts,
Herba Galii Teneri 24 parts, Heraba Moslae Diantherae 18 parts, Radix Gomphostemmae 35 parts.
Preparation method: get the raw materials ready by prescription；Raw material prepares；By Radix Rosae Sertatae, Folium Ledi Angusti, Herba Viviae Sativae, Herba Limoii Bicoloris, in seven
Perfume (or spice) is inserted in extraction vessel, adds the water of 7-15 times of weight, extracts 2-4 time, each 1-3h, and united extraction liquid also filters, and concentrates
Filtrate obtains the water extracted immersing paste of relative density 1.0-1.2；The water extracted immersing paste adds the ethanol that 6-10 times of weight concentration is 60-80% molten
Liquid, 5-10 DEG C of cold preservation stands 6-12h, takes supernatant and filter, and filtrate is concentrated to give the Purified Water extracted extract of relative density >=1.02；
Herba Galii Teneri, Heraba Moslae Diantherae, Radix Gomphostemmae coarse pulverization being placed in extraction vessel, adding 4-10 times of weight concentration is 60-80%'s
Ethanol solution, extracts 1-3 time, each 1-3h, and united extraction liquid filters, and concentrated filtrate obtains the alcohol extraction leaching of relative density >=1.02
Cream.
Described being extracted in ultrasound wave, electromagnetic wave or microwave extraction container completes.
Described concentrates as one or more in concentrating under reduced pressure, membrance concentration or centrifugal concentrating.
Described dry take lyophilization, drying under reduced pressure, drying with water bath, forced air drying, spray drying or microwave drying
In one or more.
Purified Water extracted extract and the alcohol-extracted extract of described acquirement through 70 DEG C of drying under reduced pressure and are pulverized mixing, according to a conventional method
Add the edible corn starch meeting regulation, make capsule.
Fang Zhong: Radix Rosae Sertatae controls menoxenia, gout, innominate toxic swelling；Folium Ledi Angusti regulating menstruation, control menoxenia, infertile, stomach is burst
Infections；Herba Viviae Sativae clearing away heat-damp and promoting diuresis and blood and dissolving stasis, QI invigorating are the most refreshing, control menoxenia, emission due to deficiency of the kidney；Herba Limoii Bicoloris blood yiqi, dissipate
Stasis of blood regulating menstruation, strengthening the spleen stomach invigorating；Radix Buddlejae Butterflybush QI and blood regulating, logical menstruation；Herba Galii Teneri clearing away damp-heat, dissipating blood stasis for subsidence of swelling, detoxicating, relieving inflammation, can control various inflammation
Disease, controls women's amenorrhea, controls breast carcinoma, cervical cancer etc.；Heraba Moslae Diantherae cold expelling is delivered, dispel the wind pleasant, warming middle-JIAO to relieve pain；Radix Gomphostemmae heat clearing away
Removing toxic substances, relieving cough and resolving phlegm, antiinflammatory diuresis；Radix Rosae Sertatae, Folium Ledi Angusti, Herba Viviae Sativae are monarch drug；Herba Limoii Bicoloris, Radix Buddlejae Butterflybush are ministerial drug；
Herba Galii Teneri, Radix Gomphostemmae are adjuvant drug；Heraba Moslae Diantherae is for making medicine.
Detailed description of the invention
Embodiment one: weigh Radix Rosae Sertatae 120g, Folium Ledi Angusti 30g, Herba Viviae Sativae 80g, Herba Limoii Bicoloris 90g, Radix Buddlejae Butterflybush
8g, Herba Galii Teneri 18g, Heraba Moslae Diantherae 15g, Radix Gomphostemmae 30g, by Radix Rosae Sertatae, Folium Ledi Angusti, Herba Viviae Sativae, Herba Limoii Bicoloris, Radix Buddlejae Butterflybush
Inserting in extraction vessel, add the water of 10 times of weight, extract 3 times, each 2h, united extraction liquid also filters, and concentrated filtrate obtains phase
The water extracted immersing paste to density 1.05；Adding 8 times of weight concentrations in the water extracted immersing paste is the ethanol solution of 70%, and 7 DEG C of cold preservations stand 9h,
Taking supernatant and filter, filtrate is concentrated to give the Purified Water extracted extract of relative density >=1.02；By Herba Galii Teneri, Heraba Moslae Diantherae, wooden spike
Flower coarse pulverization is placed in extraction vessel, and adding 6 times of weight concentrations is the ethanol solution of 70%, extracts 2 times, each 2h, merges
Extracting solution filters, and concentrated filtrate obtains the alcohol-extracted extract of relative density >=1.02.By Purified Water extracted extract and the alcohol extraction of described acquirement
Extractum is through 70 DEG C of drying under reduced pressure and pulverizes mixing, adds the edible corn starch meeting regulation according to a conventional method, makes capsule.
Embodiment two: weigh Radix Rosae Sertatae 140g, Folium Ledi Angusti 35g, Herba Viviae Sativae 90g, Herba Limoii Bicoloris 95g, Radix Buddlejae Butterflybush
12g, Herba Galii Teneri 24g, Heraba Moslae Diantherae 18g, Radix Gomphostemmae 35g, preparation method is with embodiment one.
Embodiment three: weigh Radix Rosae Sertatae 160g, Folium Ledi Angusti 40g, Herba Viviae Sativae 100g, Herba Limoii Bicoloris 100g, in seven
Fragrant 16g, Herba Galii Teneri 30g, Heraba Moslae Diantherae 21g, Radix Gomphostemmae 40g, preparation method is with embodiment one.
Toxicity test
1. medicine: the water of the treatment sterility and infertility of the present invention carries and alcohol extraction drying and crushing mixture, meets its matter after testing
Amount standard, deposits in exsiccator.
2, animal: healthy Kunming mouse, male and female half and half, body weight 18-22g.
3, Mouse Acute Toxicity experiment
Under maximum administration concentration and maximum administration capacity, Mouse oral gavage gives the present invention and prepares by embodiment three
Water carry and alcohol extraction drying and crushing mixture 15g/kg, Continuous Observation 14 days, test mice has no that dead and undue toxicity reacts.
Off-test, Dissection test mice, observe the main organs such as liver,kidney,spleen, the heart, lung, stomach, intestinal, be showed no abnormal change.By anxious
Property toxicity criterion, this sample belongs to nontoxic level.
Following table is acute toxicity test in mice result
4, mice long term toxicity test
The water of the present invention carries and is divided into 600mg/kg, 300mg/kg, 150mg/kg tri-groups couples with alcohol extraction drying and crushing mixture
After mice continuous oral gavage 90d, drug withdrawal recovers 28d long term toxicity test.Result display ordinary circumstance: be administered and convalescent period
Between, mice fur is smooth, and behavioral activity is normal, and body weight increases, and drinking-water of ingesting is normal；Hematology and blood parameters are being administered
Terminating and after convalescent period, mouse blood and blood parameters all fluctuated within normal range, showed no obvious abnormalities；Bone marrow and
Routine urinalysis index is after being administered end and convalescent period, and mouse bone marrow cells and routine urinalysis index show no obvious abnormalities；Histopathology refers to
Being marked on administration end and after convalescent period, Organs of Mice naked eyes show no obvious abnormalities, and each internal organs pathology shows no obvious abnormalities change.
5, mice long term toxicity test shows, the water of the present invention carries and has no poison with alcohol extraction drying and crushing mixture long term administration
Property reaction.
6, feed breeding toxicity test, select 18-22g Kun Ming mice, be randomly divided into 3 groups, often group 30 (female 20
Only, male 10), if 2 dosage groups and 1 negative control group, test group carry by the water that embodiment of the present invention three prepares and
Alcohol extraction drying and crushing mixture is respectively 1%, 2% with the ratio of feedstuff, mixes in feedstuff and feeds 90d continuously.By female after 90d
Male 2: 1 ratios carry out copulation, make dams spontaneous labor.As a result 1%, the birth survival rate of 2% dosage group filial mice and nurture survival
Rate is significantly higher than negative control group；Between 1% and 2% group, difference is the most notable.1%, 2% dosage group white mice during 5 age in days
Body weight is significantly higher than negative control group；The red blood cell count(RBC) of white mice, leukocyte meter between each dosage group and negative control group
Number and content of hemoglobin no significant difference；Between each dosage group, also there are no significant for difference.Each dosage group and negative control
There are no significant for AST, ALT difference between group and between each dosage group；Between each dosage group and negative control group and each dose
Between amount group, there are no significant for each organ coefficient difference.Each treated animal cuts open perusal each internal organs color, shapes and sizes after inspection
Etc. being showed no ANOMALOUS VARIATIONS.White mice is subject to it can thus be appreciated that the water of the Long-term Feeding present invention carries with alcohol extraction drying and crushing mixture
Pregnant rate, pregnancy rate, birth survival rate and nurture survival rate are significantly increased；Hematological indices, liver function to F1 generation white mice
And main organs is without impact, illustrate that the water of the present invention carries with alcohol extraction drying and crushing mixture white mice without obvious maternal toxicity
And fetal toxicity.
Clinical data
1, diagnosis basis: the women of child-bearing age marry more than 1 year, matrimonial cohabitation, syngamy function is normal, does not practise contraception and fails
The person of becoming pregnant, for fertility.Once there is motherhood history, and continued and be spaced more than 1 year, do not practised contraception and not pregnancy person, referred to as infertility.Its
In, get rid of congenital physiological defect and the deformity person of reproductive system.
2, experimenter's data
All experimenters are suffers from infertility clinical volunteers, totally 120 people, age 22-40 year, ill duration 1-
6 years.
3, test packet
All experimenters are divided at random 4 groups, respectively numbered matched group, test group 1, test group 2 and test group 3,
Often organize 30 people.
4, test method
Matched group: oral Nuangong Yunzi Pill (traditional Chinese medicines quasi-word Z20093578, Shaanxi Li Jun modern Chinese medicine company limited), one
Secondary 8 balls, 3 times on the one；Within 3 months, it is a course for the treatment of, after treating 1 course for the treatment of, judges curative effect；Treatment group: test 1,2,3 groups of mouths respectively
Clothes press the made capsule of embodiment one, two, three, three times a day, each 4, within 3 months, are a course for the treatment of, after treating 1 course for the treatment of
Judge curative effect.
5, efficacy assessment standard: according to family planning prenatal and postnatal care Professional Committee of the entire PLA in 2013 deliver " infertile not
Educate Diagnosis Technique specification " in the criterion of therapeutical effect of infertility pass judgment on: cure: correct protopathy normal pregnancy to term labor,
By auxiliary procreation technology, gestation is to term labor；Do not heal: the most pregnant through above Comprehensive Treatment.
6, points for attention: avoid during taking medicine and eat raw food, greasy, fish raw meat and maror, can disable after pregnancy.It addition, by
Different in conditions of patients weight and course of disease length, drug susceptibility be there is also individual variation, so patient can be according to oneself
Situation drug administration.
7, clinical test results is shown in Table.
Take Chinese medicinal capsule of the present invention and take the conventional medicine observation of curative effect to female barrenness
| Group | Number of cases | Cure | Do not heal | Total effective rate (%) |
| Matched group | 30 | 15 | 15 | 50 |
| Test group 1 | 30 | 27 | 3 | 90 |
| Test group 2 | 30 | 29 | 1 | 96.67 |
| Test group 3 | 30 | 28 | 2 | 93.33 |
As seen from the above table, matched group cures 15 people, the most 15 people, and clinical cure rate is 50%, and takes test group 1, examination
Testing in group 2 and test group 3, clinical cure rate all reaches 90%, wherein, the highest with test group 2 cure rate, and up to 96.67%, this
Invention Chinese medicinal capsule good effect, cure rate is high, has no side effect, can be as the drug use for the treatment of infertility.
In the patient of above treatment, there are 20 example gravamens, not only have infertile pain, but also suffer from height in various degree
Blood pressure, main psychological state is to worry because hypertension affects the nutrition of fetus, the again development of the frightened state of an illness.When taking the present invention's
After the Chinese medicinal capsule for the treatment of sterility and infertility, in 20 example patients, not only 19 examples are conceived, and hypertension have also been obtained in various degree
Treatment, curative effect judging standard is as follows:
(1) effective: 1. diastolic pressure declines ＞ 10mmHg, and reaches normal range；Though 2. diastolic pressure do not drop to normally
Decline 15mmHg or above person.Above two, reach its one and be effective.
(2) effective: 1. diastolic pressure declines ＜ 10mmHg, but oneself reaches normal range；2. 5-is declined before diastolic pressure is relatively treated
14mmHg, but not up to normal range；3. ＞ 20mmHg is declined before shrinking pressure relatively treatment.Above three, possess one of which person,
It is effectively.
(3) invalid: not up in effective standard any one person be invalid.
Its therapeutic outcome such as following table.
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate (%) |
| Test group 1 | 6 | 5 | 1 | 0 | 100 |
| Test group 2 | 7 | 5 | 2 | 0 | 100 |
| Test group 3 | 7 | 6 | 1 | 0 | 100 |
8, model case
King opens ××, female, 31 years old, people from Linyi, with husband marry 3 years sterile, headache and dizzy often, insomnia and dreamful sleep, face
Warming battle array to make, the most weak, cardiopalmus, red tip of the tongue, thin fur is micro-greasy, deep-thready pulse, and measuring blood pressure 16.3/12.5kPa denies there is hypertension
Medical history, father and mother non-hypertensive patient, takes the Chinese medicinal capsule prepared by embodiment of the present invention two after 3 months, cherishes the same year
Pregnant, and headache and dizzy and weak sleep quality be obviously improved, continue to take one the course for the treatment of symptom basic solution remove, measuring blood pressure
13.6/10.1kPa, recover normal work and study, do not recur in following up a case by regular visits to half a year.
Zhu's ××, female, 28 years old, people from Linan, Hangzhou, marry 6 years with husband, never conceived, see all over knowing clearly each large-scale of Hangzhou
Hospital, Ye Qu Shanghai Huashan Hospital went to a doctor, and was the most at all in progress.After take the Chinese medicinal capsule 3 prepared by embodiment two
Month, the time of about about 4 months, during taking medicine, just there are conceived sign, then drug withdrawal, raw next boy after nine months.
As known from the above, it is evident in efficacy that the Chinese medicinal capsule of the present invention not only treats sterility and infertility, more the good news is high blood
Pressing element has significant therapeutic effect；Give simultaneously and suffer from the patient that hypertension dare not give birth to and bring Gospel.
Claims (2)
1. the Chinese medicinal capsule treating sterility and infertility, it is characterised in that the Chinese medicinal capsule of this treatment sterility and infertility is by following weight
The crude drug of part is made: Radix Rosae Sertatae 120-160 part, Folium Ledi Angusti 30-40 part, Herba Viviae Sativae 80-100 part, Herba Limoii Bicoloris 90-
100 parts, Radix Buddlejae Butterflybush 8-16 part, Herba Galii Teneri 18-30 part, Heraba Moslae Diantherae 15-21 part, Radix Gomphostemmae 30-40 part.
A kind of Chinese medicinal capsule treating sterility and infertility the most as claimed in claim 1, it is characterised in that this treatment is infertile not
The Chinese medicinal capsule educated is made up of the crude drug of following weight portion: Radix Rosae Sertatae 140 parts, Folium Ledi Angusti 35 parts, Herba Viviae Sativae 90 parts, two colors
Herba Limonii Gmelinii 95 parts, Radix Buddlejae Butterflybush 12 parts, Herba Galii Teneri 24 parts, Heraba Moslae Diantherae 18 parts, Radix Gomphostemmae 35 parts.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110585A (en) * | 1994-12-26 | 1995-10-25 | 黄明和 | Efficient quick pregnancy agent for woman |
| CN1154858A (en) * | 1996-11-05 | 1997-07-23 | 李德时 | Traditional Chinese medicinal preparation for treating barrenness |
| CN1486705A (en) * | 2002-08-04 | 2004-04-07 | 秦瑞琳 | Menstruation regulating and pregnancy promoting capsule and its prepn |
| CN101428106A (en) * | 2008-12-24 | 2009-05-13 | 张铎 | Medicament composition for treating female acyesis and aphoria, and uses thereof |
-
2016
- 2016-06-27 CN CN201610528292.5A patent/CN106109641A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110585A (en) * | 1994-12-26 | 1995-10-25 | 黄明和 | Efficient quick pregnancy agent for woman |
| CN1154858A (en) * | 1996-11-05 | 1997-07-23 | 李德时 | Traditional Chinese medicinal preparation for treating barrenness |
| CN1486705A (en) * | 2002-08-04 | 2004-04-07 | 秦瑞琳 | Menstruation regulating and pregnancy promoting capsule and its prepn |
| CN101428106A (en) * | 2008-12-24 | 2009-05-13 | 张铎 | Medicament composition for treating female acyesis and aphoria, and uses thereof |
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Application publication date: 20161116 |