CN106107965A - A kind of health care instant containing Folium clausenae lansii and preparation method thereof - Google Patents
A kind of health care instant containing Folium clausenae lansii and preparation method thereof Download PDFInfo
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- CN106107965A CN106107965A CN201610454174.4A CN201610454174A CN106107965A CN 106107965 A CN106107965 A CN 106107965A CN 201610454174 A CN201610454174 A CN 201610454174A CN 106107965 A CN106107965 A CN 106107965A
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- clausenae lansii
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to field of health-care beverage, it is specially a kind of health care instant containing Folium clausenae lansii and preparation method thereof, a certain proportion of dry Folium clausenae lansii, the Radix Astragali, Poria, Radix Ophiopogonis, Radix Glycyrrhizae, fresh Rhizoma Phragmitis, Flos Lonicerae, Fructus Crataegi, Bulbus Fritillariae Cirrhosae, Fructus Momordicae, Mel, natural pigment, Rhizoma Paridis and Rhizoma Polygonati Odorati are formed with the instant of health-care effect by series of process flow process, the present invention drinks conveniently, can swelling diuretic, heat radiation of inducing sweat, promoting the circulation of QI and reducing phlegm, replenishing QI to invigorate the spleen, raising immunity of organisms；The invention has the beneficial effects as follows: make full use of Folium clausenae lansii resource and be formed with the beverage of good health-care efficacy；There is swelling diuretic, heat radiation of inducing sweat, promoting the circulation of QI and reducing phlegm, replenishing QI to invigorate the spleen, effect of raising immunity of organisms；Pure plant extract, without man-made additive；With drinking with punching, drink conveniently；Long-term drink, can be effectively improved health.
Description
Technical field
The present invention relates to field of health-care beverage, a kind of health care instant containing Folium clausenae lansii and preparation side thereof
Method.
Background technology
Clausena lansium (Lour.) Skeels, green shrub or dungarunga, high up to 12m.Collection is all had on arteries and veins below sprout, floral axis, rachis, petiole and tender leaf
Generate bunch plexi undercoat and become mildewed, savory.Imparipinnate leaf alternate；The long 4-8mm of petiolule；Vanelets 5-13, top 1
Piece maximum, tapers into downwards, avette or ellipticity lanceolar, long 6-13cm, wide 2.5-6cm, the sharp point of tip or short tapering, base
Portion's width wedge shape, asymmetric, limit is shallow wavy or has shallow cognate.The feature of Folium clausenae lansii: Folium clausenae lansii blade is oblong, the back side has
Protruding body of gland, blade face is then covered with transparent oil drop.Its branch and leaf band fragrance, rub broken after the fragrance that sends richer.Clausena lansium (Lour.) Skeels yellowish-brown
Fruit, spherical in ovum shape, pubescence is draped over one's shoulders on surface, can be edible, and wampee fruit tree is fragrant and sweet good to eat, and effect of helpful digestion.
Effect of Folium clausenae lansii: Folium clausenae lansii induces sweat heat radiation；Promoting the circulation of QI and reducing phlegm；Diuresis；Removing toxic substances.The main epidemic febrile disease of Folium clausenae lansii is generated heat；Epidemic encephalitis；Malaria；Cough
Cough phlegm dyspnea；Epigastric pain；Rheumatic arthralgia；General edema with yellowish skin；Dysuria；Pyretic toxicity scabies；Snake bite and insect sting.
Chinese patent storehouse discloses a kind of Clausena lansium (Lour.) Skeels ferment beverage and preparation method thereof (201410840091.X), belongs to drink
Product processing technique field.The preparation of Clausena lansium (Lour.) Skeels ferment beverage is with Folium clausenae lansii, Clausena lansium (Lour.) Skeels twig, Fructus clausenae lansii as raw material, by the fruit of Fructus clausenae lansii
Meat separates, gained sarcocarp cold preservation；Peel, pit mixing Folium clausenae lansii, the particle making beating of Clausena lansium (Lour.) Skeels twig；Add water and cellulose enzyme powder is entered
Row reaction is decomposed, through yeast fermentation；Adding and gallisize, inoculating lactic acid bacterium ferments；Tunning is separated and takes clear liquid mixing
Sarcocarp, 7 days Clausena lansium (Lour.) Skeels ferment beverages achieved above of sealing and standing.The present invention makes full use of Folium clausenae lansii and Clausena lansium (Lour.) Skeels twig, it is achieved large quantities of
Amount produces the Clausena lansium (Lour.) Skeels ferment beverage that quality is superior, and production process maturation is controlled；Meanwhile, keep Fructus clausenae lansii sarcocarp nutritional labeling and
New tender form, it is thus achieved that abundant nutrition and splendid mouthfeel.
Disclosing the preparation method (CN201310635641.X) of a kind of Cortex Clausenae Excavatae tea in Chinese patent storehouse, its feature exists
In: it comprises the steps: (1) leaf picking: plucking Cortex Clausenae Excavatae tender leaf is raw material；(2) just spreading for cooling: Cortex Clausenae Excavatae tender leaf is spread
In dustpan, carrying out spreading for cooling in indoor, spreading for cooling thickness is 0.5～1cm, spreads time 1～2h, every dustpan stand blue or green 1～1.5kg；
(3) tremble green grass or young crops at the beginning of: the Cortex Clausenae Excavatae leaf 2 after first spreading for cooling～3 dustpans being spelled is 1 dustpan, shake back and forth with hands to stir and carry out trembling green grass or young crops；
(4) two spreadings for cooling: will just tremble in the Cortex Clausenae Excavatae leaf holding chamber after green grass or young crops 1～2h；(5) two tremble green grass or young crops: by the Cortex Clausenae Excavatae leaf 4 after two spreadings for cooling～
It is 1 dustpan that 5 dustpans are spelled, and shakes back and forth with hands to stir and carries out secondary and tremble green grass or young crops；(6) three spreadings for cooling: tremble the Cortex Clausenae Excavatae after green grass or young crops by two
Leaf puts indoor 6～10？h；(7) complete: the Cortex Clausenae Excavatae leaf after three spreadings for cooling is completed at 100～150 DEG C 2～5min；(8) light
Rub: the Cortex Clausenae Excavatae leaf after completing loads rolling bag, gently rub 20～30 times by hand；(9) dry: the Cortex Clausenae Excavatae leaf after gently rubbing dries
Do to water content 6～7%；I.e. can get Cortex Clausenae Excavatae tea；(10) finished product: the Cortex Clausenae Excavatae tea package storage after drying.
Folium clausenae lansii in state-owned bigger storage, and have the highest medical value, as heat radiation of inducing sweat, promoting the circulation of QI and reducing phlegm, diuresis,
Removing toxic substances, the most carefully developing Folium clausenae lansii is a good problem to study.
Summary of the invention
For the problems referred to above, it is an object of the invention to provide a kind of health care instant containing Folium clausenae lansii and preparation side thereof
Method, by a certain proportion of dry Folium clausenae lansii, the Radix Astragali, Poria, Radix Ophiopogonis, Radix Glycyrrhizae, fresh Rhizoma Phragmitis, Flos Lonicerae, Fructus Crataegi, Bulbus Fritillariae Cirrhosae, Fructus Momordicae,
Mel, natural pigment, Rhizoma Paridis and Rhizoma Polygonati Odorati are formed with the instant of health-care effect by series of process flow process, this
Bright drink conveniently, can swelling diuretic, heat radiation of inducing sweat, promoting the circulation of QI and reducing phlegm, replenishing QI to invigorate the spleen, raising immunity of organisms.
To achieve these goals, the present invention uses below scheme
According to the first aspect of the invention, it is provided that a kind of health care instant containing Folium clausenae lansii, by weight, including
Following components: dry Folium clausenae lansii 5-15 part, Radix Astragali 1-3 part, Poria 1-3 part, 0.8-1.5 part Radix Ophiopogonis, Radix Glycyrrhizae 1-2.5 part, fresh Rhizoma Phragmitis
2-5 part, Flos Lonicerae 1.5-3 part, Fructus Crataegi 1-2 part, Bulbus Fritillariae Cirrhosae 0.3-0.8 part, Fructus Momordicae 1.5-3 part, Mel 3-5 part, pigment
0.3-0.8 part, Rhizoma Paridis 0.2-1 part, Rhizoma Polygonati Odorati 2-3 part.
Preferably, a kind of health care instant containing Folium clausenae lansii, by weight, including following components: dry Folium clausenae lansii
12 parts, the Radix Astragali 2 parts, 2.5 parts of Poria, Radix Ophiopogonis 1.2 parts, 1.8 parts of Radix Glycyrrhizae, fresh Rhizoma Phragmitis 4 parts, Flos Lonicerae 2.4 parts, Fructus Crataegi 1.5 parts, river
Bulbus Fritillariae Uninbracteatae 0.6 part, Fructus Momordicae 2.5 parts, Mel 4.5 parts, pigment 0.5 part, Rhizoma Paridis 0.8 part, Rhizoma Polygonati Odorati 2.5 parts.
Preferably, described pigment is natural pigment.
Preferably, described pigment is that caramel color, annatto pigment, monascorubin, Gardenia Yellow or Fructus Capsici are red
Element.
According to the second aspect of the invention, it is provided that the preparation method of a kind of health care instant containing Folium clausenae lansii, its bag
Include following steps:
(1) by dry Folium clausenae lansii shredding；By the Radix Astragali, Poria, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Crataegi, Rhizoma Polygonati Odorati section；By Bulbus Fritillariae Cirrhosae, Fructus Momordicae
Crushing；Fresh Rhizoma Phragmitis is squeezed the juice filtration, prepare fresh reed juice；
(2) dry Folium clausenae lansii, Flos Lonicerae, Rhizoma Paridis being placed in pot, add the solution of 15-30 part, solution is water, adopts
Extract 3-5h with thermal reflux, maintain the temperature at 85-100 DEG C, after natural cooling, be filtrated to get solution A；
(3) Radix Astragali, Poria, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Crataegi, Bulbus Fritillariae Cirrhosae, Fructus Momordicae are placed in pot, add 25-50 part solution,
Solution is water, uses thermal reflux to extract 4-6h, maintains the temperature at 85-100 DEG C, naturally cools to 30-40 DEG C and adds Mel,
Solution B it is filtrated to get after natural cooling；
(4) fresh reed juice, solution A, solution B are mixed, stir；
(5) add pigment as required, stir, obtain solution C；
(6) use concentration technology that solution C is concentrated, obtain concentrated solution D；
(7) use drying process that concentrated solution D is dried, obtain solid matter E；
(8) using pulverizer to pulverize solid matter E, obtain granule F, after pulverizing, the particle diameter of granule F is 60-120
Mesh；
(9) filling machine is used to be filled in container by granule F.
Preferably, in step (2) and step (3), described pot is evaporation boiler.
Preferably, in step (2) and step (3), described thermal reflux coordinates micro-in practical operation
Ripple extractive technique or ultrasonic wave extraction use.
Preferably, in step (6), described concentration technology is membrance concentration technology.
Preferably, in step (7), described drying process is spray drying technology.
Preferably, in step (7), the water content of described solid matter E is less than 1%.
Preferably, in step (9), described filling machine is aseptic filler.
Preferably, in step (9), described container is tank container or plastic bag.
Folium clausenae lansii is containing acid amide (neoclausenamide) in new Clausena lansium (Lour.) Skeels, different new Clausena lansium (Lour.) Skeels lactams
(isoneoclausenamide), Clausena lansium (Lour.) Skeels lactams (clausenamide), ring Clausena lansium (Lour.) Skeels lactams
(cyclocaausenamide), a kind of new lactams and ε-valerolactam (ε-valerolactam), high Clausena lansium (Lour.) Skeels lactams
(homoclausenamide) and ξ-Clausena lansium (Lour.) Skeels lactams (ξ-clausenamide), Coumarins compound print Clausena lansium (Lour.) Skeels lactone
(indicolactone), anistree Clausena lansium (Lour.) Skeels lactone (anisolactone), 2 ", 3 "-epoxy anise Clausena lansium (Lour.) Skeels lactone (2 ", 3 "-
epoxyanisolactone).Aerial parts terpene alcohol (lansiol) i.e. 3 beta-hydroxy-23 Han Triterpenoids Clausena lansium (Lour.) Skeels, 24,24-trimethyls
Lanostane-9 (11), 25-diene [3 β-hydroxy-23,24,24-trime-thyllanosta-9 (11), 25-diene],
Clausena lansium (Lour.) Skeels acid imide (lansimide) etc..Effect: heat radiation of inducing sweat；Promoting the circulation of QI and reducing phlegm；Diuresis；Removing toxic substances.Main epidemic febrile disease is generated heat；Epidemic encephalitis；Malaria
Disease；Cough phlegm dyspnea；Epigastric pain；Rheumatic arthralgia；General edema with yellowish skin；Dysuria；Pyretic toxicity scabies；Snake bite and insect sting.
The invention has the beneficial effects as follows: make full use of Folium clausenae lansii resource and be formed with the beverage of good health-care efficacy；Have and disappear
Swollen diuresis, heat radiation of inducing sweat, promoting the circulation of QI and reducing phlegm, replenishing QI to invigorate the spleen, effect of raising immunity of organisms；Pure plant extract, without manually adding
Add agent；With drinking with punching, drink conveniently；Long-term drink, can be effectively improved health.
Detailed description of the invention
For the problems referred to above, it is an object of the invention to provide a kind of health care instant containing Folium clausenae lansii and preparation side thereof
Method, by a certain proportion of dry Folium clausenae lansii, the Radix Astragali, Poria, Radix Ophiopogonis, Radix Glycyrrhizae, fresh Rhizoma Phragmitis, Flos Lonicerae, Fructus Crataegi, Bulbus Fritillariae Cirrhosae, Fructus Momordicae,
Mel, natural pigment, Rhizoma Paridis and Rhizoma Polygonati Odorati are formed with the instant of health-care effect by series of process flow process, this
Bright drink conveniently, can swelling diuretic, heat radiation of inducing sweat, promoting the circulation of QI and reducing phlegm, replenishing QI to invigorate the spleen, raising immunity of organisms.
To achieve these goals, the present invention uses below scheme
According to the first aspect of the invention, it is provided that a kind of health care instant containing Folium clausenae lansii, by weight, including
Following components: dry Folium clausenae lansii 5-15 part, Radix Astragali 1-3 part, Poria 1-3 part, 0.8-1.5 part Radix Ophiopogonis, Radix Glycyrrhizae 1-2.5 part, fresh Rhizoma Phragmitis
2-5 part, Flos Lonicerae 1.5-3 part, Fructus Crataegi 1-2 part, Bulbus Fritillariae Cirrhosae 0.3-0.8 part, Fructus Momordicae 1.5-3 part, Mel 3-5 part, pigment
0.3-0.8 part, Rhizoma Paridis 0.2-1 part, Rhizoma Polygonati Odorati 2-3 part.
Preferably, a kind of health care instant containing Folium clausenae lansii, by weight, including following components: dry Folium clausenae lansii
12 parts, the Radix Astragali 2 parts, 2.5 parts of Poria, Radix Ophiopogonis 1.2 parts, 1.8 parts of Radix Glycyrrhizae, fresh Rhizoma Phragmitis 4 parts, Flos Lonicerae 2.4 parts, Fructus Crataegi 1.5 parts, river
Bulbus Fritillariae Uninbracteatae 0.6 part, Fructus Momordicae 2.5 parts, Mel 4.5 parts, pigment 0.5 part, Rhizoma Paridis 0.8 part, Rhizoma Polygonati Odorati 2.5 parts.
Preferably, described pigment is natural pigment.
Preferably, described pigment is that caramel color, annatto pigment, monascorubin, Gardenia Yellow or Fructus Capsici are red
Element.
According to the second aspect of the invention, it is provided that the preparation method of a kind of health care instant containing Folium clausenae lansii, its bag
Include following steps:
(1) by dry Folium clausenae lansii shredding；By the Radix Astragali, Poria, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Crataegi, Rhizoma Polygonati Odorati section；By Bulbus Fritillariae Cirrhosae, Fructus Momordicae
Crushing；Fresh Rhizoma Phragmitis is squeezed the juice filtration, prepare fresh reed juice；
(2) dry Folium clausenae lansii, Flos Lonicerae, Rhizoma Paridis being placed in pot, add the solution of 15-30 part, solution is water, adopts
Extract 3-5h with thermal reflux, maintain the temperature at 85-100 DEG C, after natural cooling, be filtrated to get solution A；
(3) Radix Astragali, Poria, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Crataegi, Bulbus Fritillariae Cirrhosae, Fructus Momordicae are placed in pot, add 25-50 part solution,
Solution is water, uses thermal reflux to extract 4-6h, maintains the temperature at 85-100 DEG C, naturally cools to 30-40 DEG C and adds Mel,
Solution B it is filtrated to get after natural cooling；
(4) fresh reed juice, solution A, solution B are mixed, stir；
(5) add pigment as required, stir, obtain solution C；
(6) use concentration technology that solution C is concentrated, obtain concentrated solution D；
(7) use drying process that concentrated solution D is dried, obtain solid matter E；
(8) using pulverizer to pulverize solid matter E, obtain granule F, after pulverizing, the particle diameter of granule F is 60-120
Mesh；
(9) filling machine is used to be filled in container by granule F.
Preferably, in step (2) and step (3), described pot is evaporation boiler.
Preferably, in step (2) and step (3), described thermal reflux coordinates microwave extraction technology in practical operation
Or ultrasonic wave extraction uses.
Preferably, in step (6), described concentration technology is membrance concentration technology.
Preferably, in step (7), described drying process is spray drying technology.
Preferably, in step (7), the water content of described solid matter E is less than 1%.
Preferably, in step (9), described filling machine is aseptic filler.
Preferably, in step (9), described container is tank container or plastic bag.
Water bath reflux method:
Reflux extraction is with volatile organic solvent extraction material compositions such as ethanol, and leachate is added thermal distillation, its
Middle volatile solvent is cooled again after distillating, and repeating to flow back to leach in container to extract raw material, so going round and beginning again, until effectively becoming
Divide reflux, extract, method completely.Circumfluence method extracting solution heated time in evaporation boiler is longer, therefore is not suitable for being heated and subjects to brokenly
The leaching of bad material composition.
Membrance concentration isolation technics:
Under pressure, when stock solution flows through film surface, the tiny micropore of many gathered in film surface only allows water
And small-molecule substance by and become permeate, in stock solution, volume is then trapped within film more than the material in film surface micropore footpath
Liquid feeding side, becomes concentrated solution, thus realizes the separation to stock solution and the purpose of concentration.
Spray drying technology:
By mechanism, the material that will need to be dried, it is dispersed into the thinnest microgranule as mist, (increases moisture evaporation
Area, accelerates dry run) and hot air, in moment, most of moisture is removed, make the solid matter in material be dried
Become powder.
Folium clausenae lansii is odd number winglike compound leaf, lobule 5-13 sheet, many shrinkages, and broken, yellow green is to bottle green, and complete person is wealthy
Avette or ovum shape is oval, and gather tiny translucent oil drop and thin pubescence, long 4-13cm, wide 2-5cm, tip anxious the sharpest or short gradually
Point, base portion wedge shape is to circular, anisopleual, wavy to the shallow crenation of Ye Quanyuan or shallow, slightly warp, and vein is recessed in blade face,
Protruding in the back side, petiolule is by pubescence, and long 2-4mm, matter is crisp.Gas is fragrant, and mildly bitter flavor is pungent.Microscopical identification leaf cross section: upper epidermis
Cell is deltiod or rectangle, by horny layer；Lower epidermis cell is less, has most pore and nonglandular hair.Palisade tissue is 1-2
Row cell；Spongy tissue closes most calcium oxalate cluster crystal and minority prismatic crystal.Master pulse paper tube Shu Zhouren formula, pericyclic fiber bundle is yellowish
Color.Intermittent arrangement is circlewise.Mesophyll tissue there is large-scale secretory cell (diameter 40-200 μm) be dispersed in.[br] powder characteristics: yellow
Green.1. calcium oxalate cluster crystal is more, and corner angle are the most blunt, diameter 15-35 μm；Also there is minority prism of calcium oxalate；2. nonglandular hair finger-like is extremely
Conico-acuminate, diameter 30-50 μm, long 70-240 μm；3. epidermal surface is seen in polygon, and pore mostly is infinitive, minority
For ring type, subsidiary cell 4-6 is individual；4. pericyclic fiber wall is thicker, diameter 30-40 μm, around parenchyma cell have containing oxalic acid bunch
Brilliant；5. wood fiber outer wall is wavy, and cell is slightly larger, diameter 40-70 μm；6. conduit mostly is reticulate pattern and screw thread, diameter 60-100 μm.
Folium clausenae lansii is containing acid amide (neoclausenamide) in new Clausena lansium (Lour.) Skeels, different new Clausena lansium (Lour.) Skeels lactams
(isoneoclausenamide), Clausena lansium (Lour.) Skeels lactams (clausenamide), ring Clausena lansium (Lour.) Skeels lactams
(cyclocaausenamide), a kind of new lactams and ε-valerolactam (ε-valerolactam), high Clausena lansium (Lour.) Skeels lactams
(homoclausenamide) and ξ-Clausena lansium (Lour.) Skeels lactams (ξ-clausenamide), Coumarins compound print Clausena lansium (Lour.) Skeels lactone
(indicolactone), anistree Clausena lansium (Lour.) Skeels lactone (anisolactone), 2 ", 3 "-epoxy anise Clausena lansium (Lour.) Skeels lactone (2 ", 3 "-
epoxyanisolactone).Aerial parts terpene alcohol (lansiol) i.e. 3 beta-hydroxy-23 Han Triterpenoids Clausena lansium (Lour.) Skeels, 24,24-trimethyls
Lanostane-9 (11), 25-diene [3 β-hydroxy-23,24,24-trime-thyllanosta-9 (11), 25-diene],
Clausena lansium (Lour.) Skeels acid imide (lansimide) etc..
Effect of Folium clausenae lansii: heat radiation of inducing sweat；Promoting the circulation of QI and reducing phlegm；Diuresis；Removing toxic substances.Main epidemic febrile disease is generated heat；Epidemic encephalitis；Malaria；Cough expectorant
Breathe heavily；Epigastric pain；Rheumatic arthralgia；General edema with yellowish skin；Dysuria；Pyretic toxicity scabies；Snake bite and insect sting.
The Radix Astragali, has another name called Radix Astragali, for plant and the general designation of Chinese crude drug.The plant Radix Astragali originates in the Inner Mongol, Shanxi, Gansu, black dragon
The ground such as river, for state three level protecting plant.The Chinese crude drug Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, has
The effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The Radix Astragali containing Saponin, sucrose, polysaccharide, several amino acids, folic acid and
The various trace elements such as selenium, zinc, copper.The Radix Astragali is the medicine for improving lung and respiratory system immunocompetence most basic in Chinese medicine
Material. may be used for the sweating due to debility disease caused because of hypoimmunity. can be used for QI invigorating and promote spleen function and metabolic capacity
Lowly, the life Radix Astragali, have effect of benefiting QI for strengthening the superficies, inducing diuresis to remove edema, detoxification, granulation promoting, it is adaptable to spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema,
Carbuncle is not burst or is burst and the disease such as do not holds back for a long time.Radix Astragali (processed with Mel) have QI invigorating, nourish blood, effect in benefit, it is adaptable to internal injury overstrain, diarrhea due to hypofunction of the spleen,
The diseases such as the deficiency of vital energy, blood deficiency, weakness of QI.The Radix Astragali have reduction blood viscosity, reduce thrombosis, reduce blood pressure, cardioprotection, two-way
Regulation blood glucose, free radical resisting damage, defying age, anti-hypoxia, antitumor, enhancing human body immunity power effect, can be used to treat heart
The diseases such as disease, hypertension, diabetes.The Radix Astragali can also expand blood vessel, improves cutaneous circulation and nutriture, therefore to chronic ulcer
Disunion person is effective for a long time.It can also eliminate the albuminuria of nephritis patient, the liver protecting, prevents hepatic glycogen from reducing.
Poria can spleen invigorating, again can eliminating dampness by diuresis, for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has specimen to hold concurrently
The effect of Gu, often and the compatibility such as Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae；Can be used as again tonifying the lung spleen, control the adjuvant of the deficiency of vital energy；Can not transport for insufficiency of the spleen
Change water wet, stop the disease of the raw phlegm retention of dimerization, there is therapeutical effect；Poria energy tranquilizing by nourishing the heart, therefore can be used for irritability, cardiopalmus, mistake
The diseases such as dormancy；Poria function promoting diuresis to eliminate damp pathogen, and mild in medicine property and, diuretic and do not hinder healthy energy, for promoting diuresis to eliminate damp pathogen key medicine.All dysuria,
The disease of retention of water-damp, though relatively cold-damp, or the most damp and the hottest, or belong to insufficiency of the spleen wet poly-, all can fit applications.Such as relatively cold-damp
Person, can be with the compatibility such as Ramulus Cinnamomi, the Rhizoma Atractylodis Macrocephalae；Relatively damp and hot person, can be with the compatibility such as Polyporus, Rhizoma Alismatis；The person that belongs to deficiency of spleen-QI, can with Radix Codonopsis,
The compatibility such as Radix Astragali, the Rhizoma Atractylodis Macrocephalae；Belong to deficiency and coldness person, also can join Radix Aconiti Lateralis Preparata, Rhizoma Atractylodis Macrocephalae equivalent use.
Radix Ophiopogonis cold nature, sweet and slightly bitter taste.Radix Ophiopogonis contains multiple steroid saponin, carotene, phlegmatic temperament, saccharide, stigmasterol etc.
Composition.Pharmacological evaluation proves, Radix Ophiopogonis has leukocyte increasing, extends antibody and there is the effect of time, improves immunologic function and core
Acid synthetic ratio, promotes that the immune materials such as antibody, complement, interferon, lysozyme produce.Therefore Radix Ophiopogonis has enhancing healthy energy, reinforcement
Anti-evil effect, thus reduce the generation of disease.Radix Ophiopogonis, decoct had sedation.Radix Ophiopogonis also can strengthen the sedation of chlorpromazine,
Strengthen the syngignoscism of pentobarbital sodium, the excitation of antagonism caffeine, the tic that dimefline causes can be postponed, tatanic frightened
Faint and the dead time occurred, but animal can not be made to avoid death.Additionally, soaked drink the work that cardiac muscle is had contractive amplitude Radix Ophiopogonis
With.Guinea pig isolated heart perfusion method shows, ophiopogon root total saponin and total amino acids low dose all can make myocardial contraction strengthen, arteria coronaria
Flow increase, heavy dose then suppress cardiac muscle, reduce coronary flow, but both on heart rate without impact.
Radix Glycyrrhizae is the root and rhizome of herbaceos perennial Radix Glycyrrhizae, and nature and flavor are sweet flat, GUIXIN, lung, spleen, stomach warp.Tool spleen reinforcing benefit
Gas, nourishing the lung to arrest cough, relieving spasm to stop pain, the merit of the mitigation property of medicine, its effective ingredient is glycyrrhizin, enoxolone, 4',7-Dihydroxyflavanone, Radix Glycyrrhizae
Polysaccharide is one of Chinese herbal medicine of commonly using clinically.Radix Glycyrrhizae cures mainly: invigorating the spleen and replenishing QI, for insufficiency of heart-QI, and severe palpitation, irregularly intermittent and regularly intermittent pulse, with
And deficiency of spleen-QI and stomach-QI, fatigue and weakness etc.；Relieving spasm to stop pain, is used for having a stomachache, suffers from abdominal pain and gastrocnemius contraction urgency pain etc., often and the same use of Radix Paeoniae,
The curative effect controlling contraction urgency pain can be obviously enhanced, such as peony and licorice decoction；Expelling phlegm for arresting cough, Radix Glycyrrhizae has relieving cough and resolving phlegm effect, for trachea
Inflammation, the cough with copious phlegm that emophysematous disease causes, asthma, glutinous expectorant is difficult to the diseases such as discharge；Heat-clearing and toxic substances removing, for ulcer sores, throat
Swell and ache, noxious dampness, there is antibacterial and anti-inflammation functions.Can also be used for reducing the Detoxication of other Chinese medicines.
Rhizoma Phragmitis, Chinese medicine name, for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Rhizoma Phragmitis controls lung
Heat cough, lung abscess vomiting pus；Rhizoma Phragmitis enters lung meridian and is apt to clear lung-heat, and Rhizoma Phragmitis controls calentura excessive thirst；Rhizoma Phragmitis sweet in the mouth is trembled with fear, and it is puckery that Rhizoma Phragmitis controls pyretic stranguria
Bitterly, Rhizoma Phragmitis function clearing away heat and promoting diuresis, can use and control the puckery pain of pyretic stranguria, oliguria with reddish urine, often join Rhizoma Imperatae, Semen Plantaginis etc. and use；This product sweet in the mouth is trembled with fear,
Clear lung gastric qi can divide excess-heat, again can promoting the production of body fluid to quench thirst, relieving restlessness, therefore available control consumption of body fluid caused by febrile disease, dysphoria with smothery sensation thirster；Rhizoma Phragmitis is used for stomach
Vomiting due to heat is told.Rhizoma Phragmitis can clearing heat to ease the stomach preventing or arresting vomiting, the most do not grow the greasy stomach that hinders, therefore vomit the key medicine of the sound of vomiting for controlling gastric heat.
Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times by the traditional Chinese medical science, and the stem of Flos Lonicerae, leaf and Huadu can be used as medicine, have solution
Poison, antiinflammatory, kill virus, sterilize, diuresis and antipruritic effect.Effect of concrete Flos Lonicerae is as follows with effect: 1, resisting pathogenic microbes
Effect.Flos Lonicerae is to various pathogens such as staphylococcus aureus, Hemolytic streptococcus, escherichia coli, dysentery bacterium, cholera arc
Bacterium, Bacillus typhi, Salmonella paratyphi etc. all have certain inhibitory action；2. anti inflammatory detoxication effect, has carbuncle furuncle, acute appendicitis lung abscess
Stronger scattered carbuncle detumescence, heat-clearing and toxic substances removing, antiinflammation；3. dredge heat and dissipate heresy effect, to affection due to external wind and heat or epidemic febrile disease from the beginning of, fever of the body head
Bitterly, vexed sleep less, coma crimson tongue, dry mouth and throat etc. have certain effect；4. eliminating pathogenic heat from blood to cure dysentery effect, to pyretic toxicity dysentery, dysentery pus and blood,
Hygropyrexia resistance larynx, laryngopharynx swelling and pain etc. have the effect of removing toxic substances dysentery relieving removing heat from blood sore-throat relieving；5. Flos Lonicerae tea sweet in the mouth, cold in nature, there is heat-clearing and toxic substances removing, dredge
Dissipate the effect of wind heat.Flos Lonicerae has heat-clearing and toxic substances removing, dredges throat, the effect of relieving restlessness of relieving summer heat.Can treat febrile disease due to summer-heat pathogen, dysentery, influenza,
The diseases such as furuncle toxic swelling, acute and chronic tonsillitis, periodontitis.
Fructus Crataegi, edible plants, stone fruit, matter is hard, and sarcocarp is thin, and taste is micro-sour and astringent.Machaka, the close life of branch, have thin
Thorn, sprout has pubescence.Sprig puce, old branch taupe.Can prevention and cure of cardiovascular disease.Fructus Crataegi has skin care weight reducing, is woman
Weight-reducing tablet, Fructus Crataegi contains the material such as vitamin C, carotene can block and reduce the generation of free radical, can the exempting from of enhancing body
Epidemic disease power, has anti-aging, anticancer effect；Women eats Fructus Crataegi more and can eliminate body fat, reduce effect of fat absorption, for liking
Beautiful women can reach the effect of U.S. face weight reducing；Fructus Crataegi has blood pressure lowering, blood fat reducing, antioxidation, enhancing immunity, removes gastrointestinal tract
Noxious bacteria etc., also can prevent liver cancer.Male obtained fatty liver it is necessary to nourishing and protecting liver, nourishing and protecting liver, first elects Fructus Crataegi.Fructus Crataegi, energy
Aid digestion, there is nourishing the liver and go fat effect；Fructus Crataegi can significantly reduce serum cholesterol and triglyceride, effectively prevents and treats Atherosclerosis
Change；Fructus Crataegi can also be by strengthening myocardial contraction, increasing cardiac output, coronary artery dilator blood vessel, increase coronary flow, fall
Low myocardial oxygen consumption etc. play heart tonifying and prevent anginal effect.Additionally, the total flavones in Fructus Crataegi has expansion blood vessel with persistently
The effect of blood pressure lowering.
Effect of Bulbus Fritillariae Cirrhosae: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, band of coughing up phlegm
Blood.Function controls cough due to consumptive disease, spitting of blood of spitting, ambition Yu Jie, consumptive lung disease, lung abscess, sore throat, acute mastitis.The effect of Bulbus Fritillariae Cirrhosae: this taste
Hardship, cold nature, return lung meridian, there is the merit of clearing heat, eliminating phlegm, relieving cough, can be used for treating expectorant heat syndrome cough and breathe heavily, yellow thick card of coughing up phlegm；Hold concurrently again sweet
Taste, therefore kind nourishing the lung to arrest cough, treatment lung has the deficiency syndrome such as the card that scorching cough expectorant is few and viscous, and deficiency of YIN cough caused by dryness chronic cough；Also has eliminating stagnation
The diseases such as the merit of dissipating depression of QI, the treatment uncomfortable in chest vexed card caused by combination of phlegm and heat, and scrofula sucutaneous nodule.Additionally, it is Bulbus Fritillariae Cirrhosae and Os Sepiae, sweet
Grass is powder, i.e. Medicinal powder of cuttlefish and firtillary bulb, and treatment gastric ulcer is effective.
A kind of rare medicinal herbs of Fructus Momordicae, sweet in the mouth cool in nature, function lung heat clearing intestine moistening. curing mainly pertussis, phlegm-fire cough, blood is dry just
Secret disease such as grade；For treatment acute tracheitis, acute tonsillitis, throat fire, acute gastritis has good curative effect, with its root
Smash to pieces, spread on affected part, stubborn dermatitis, carbuncle, furuncle etc. can be controlled；Really Mao Kezuo drug for incised wound；A little with Fructus Momordicae, pour boiled water leaching
Bubble, is a kind of fabulous refreshment drink, both can refresh oneself and promote the production of body fluid, again can preventing respiratory tract infection, take throughout the year, can life lengthening.
Additionally, Fructus Momordicae is the most often fabricated to fruit juice by people, or endure together with some other materials such as Herba Leonuri, Herba Houttuyniae etc.
System, all can play good medical care effect.
Mel sweet in the mouth, property are flat, return spleen, lung, the heart, stomach, large intestine channel.Have nourshing Yin and drynsessmoistening prescription, qi-restoratives lung moistening, detoxify, be in harmonious proportion all
The effect of medicine.It is usually used in xeropulmonary cough, body void, dryness of the intestine constipation, aphtha, burn due to hot liquid or fire, gastralgia, it is also possible to solve Aconitum carmichjaelii Debx., attached
The poison of son.Containing fructose, glucose, enzyme, protein, vitamin and several mineral materials in Mel.Often eat and can prevent and treat anemia, the heart
Disease of ZANG-organs, gastroenteropathy etc., and body immunity can be improved.Monosaccharide: glucose and fructose can be the most digested；Enzyme:
Various enzymes can promote that many kinds of substance is digested and assimilated by human body；Acetylcholine: allaying tiredness, excitor nerve, raising memory；
Flavone: antioxidation, improves immunity of organisms.Mel=human serum, Mel is the natural nutrient food being widely recognized.Test
Show, containing various inorganic salts similar to human serum concentration in Mel, such as ferrum, calcium, copper, manganese, potassium, phosphorus etc., the most multiple
Vitamin and organic acid, therefore Mel is referred to as " king of serum ".Containing pollen grain in Mel, often drinking Mel can be to pollen grain
Allergy produces certain resistance: contains the toxicity liquid Venenum apis of denier in Mel, also has certain anti-allergic effects,
It is commonly used for the treatment of the anaphylactic disease such as bronchitis, asthma clinically.Eat one spoonful of Mel every day, it is possible to away from heavy breathing
Breathe heavily, the allergic symptom such as pruritus.
Rhizoma Paridis is heat-clearing and toxic substances removing medical herbs simply, and medicinal history is long, is always described as snakebite carbuncle medicine.This medical instrument
There is effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Among the people being usually used in treats mumps, tonsillitis, laryngopharynx swelling and pain, mammary gland
Inflammation, traumatic injury, venom, sore and toxic etc..It has stronger bacteriostasis to Asia influenza A, to dysentery bacillus, pair
Bacillus typhi, paracolon etc., have bacteriostasis.
Rhizoma Polygonati Odorati belongs to the product that nourishing Yin and keeping spirit is enriched blood, and ancients claim flat benefit of Rhizoma Polygonati Odorati to moisten, and has the merit except wind heat concurrently, therefore profit of preserving youthful looks
Skin, eliminates disease and prolong life.Rhizoma Polygonati Odorati is mended and oiliness, cold the driest, therefore has " tonification the five internal organs, nourish QI and blood, flat benefit and moisten, hold concurrently except wind heat " it
Merit, informal dress Rhizoma Polygonati Odorati can defying age, life lengthening.Rhizoma Polygonati Odorati energy nourishing YIN and moistening the lung；Promoting the production of body fluid to quench thirst.Cough caused by dryness；Chronic cough；Calentura the moon liquid consumption hinders it
Dry throat and mouth；Interior-heat is quenched one's thirst；Deficiency of YIN diseases caused by exogenous pathogenic factor；Dizzy dizziness；Muscle arteries and veins spasm and pain.Cure mainly the few expectorant of the dry cough caused by deficiency of lung-YIN, swallow dryness of the tongue
With epidemic febrile disease later stage, or diseases such as Tianjin of occurring is few the most thirsty, inappetence, stomach discomfort because hyperpyrexia consumption impairment of body fluid liquid.
For the technical scheme making those skilled in the art be better understood from the application, come below in conjunction with embodiment
Technical scheme is clearly and completely described, it is clear that described embodiment is only the part of the application
Embodiment, based on the embodiment in the application, those of ordinary skill in the art are obtained under not making creative work premise
The every other embodiment obtained, all should belong to the scope of the application protection.
The formula of the health care instant of embodiment 1-3 and comparative example 1-3 is shown in Table 1.
Table 1
The formula of the health care instant of embodiment 4-6 and comparative example 4-6 is shown in Table 2.
Table 2
The instant that above-described embodiment and comparative example prepare, respectively through 20-55 year 500 personnel try out 45 continuously
My god, every day, 40g, the most each 20g, took after mixing it with water with 250ml warm water, and 500 people are divided into the group of edematous condition, have urine to have some setbacks symptom
Group, have the group of the symptom that brings up phlegm when one coughs, have the group of symptom of getting angry, have the group of taste digestion aspect symptom, often organize 100
People, the health care of instant obtained in the various embodiments described above is evaluated in relative analysis.Wherein, described health-care effect is health
Edema of the limbs eliminates, urine smoothly, cough with asthma disappear, throat without expectorant, transference cure of getting angry, taste eupepsia etc., experiment is divided into
In two stages, 1-15 days first stage, the results are shown in Table 3-1, second stage 16-45 days, the results are shown in Table 3-2.
Table 3-1
Table 3-2
The preparation method of above-described embodiment 1-6 is as follows:
(1) by dry Folium clausenae lansii shredding；By the Radix Astragali, Poria, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Crataegi, Rhizoma Polygonati Odorati section；By Bulbus Fritillariae Cirrhosae, Fructus Momordicae
Crushing；Fresh Rhizoma Phragmitis is squeezed the juice filtration, prepare fresh reed juice；
(2) dry Folium clausenae lansii, Flos Lonicerae, Rhizoma Paridis being placed in pot, add the solution of 15-30 part, solution is water, adopts
Extract 3-5h with thermal reflux, maintain the temperature at 85-100 DEG C, after natural cooling, be filtrated to get solution A；
(3) Radix Astragali, Poria, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Crataegi, Bulbus Fritillariae Cirrhosae, Fructus Momordicae are placed in pot, add 25-50 part solution,
Solution is water, uses thermal reflux to extract 4-6h, maintains the temperature at 85-100 DEG C, naturally cools to 30-40 DEG C and adds Mel,
Solution B it is filtrated to get after natural cooling；
(4) fresh reed juice, solution A, solution B are mixed, stir；
(5) add pigment as required, stir, obtain solution C；
(6) use concentration technology that solution C is concentrated, obtain concentrated solution D；
(7) use drying process that concentrated solution D is dried, obtain solid matter E；
(8) using pulverizer to pulverize solid matter E, obtain granule F, after pulverizing, the particle diameter of granule F is 60-120
Mesh；
(9) filling machine is used to be filled in container by granule F.
The health care instant of the present invention for being prepared by said method, carries out the detection of composition and quality standard,
Result is as follows:
(1) color: light yellow or blush；
(2) taste: micro-sweet, drink person feels that throat is smooth, and taste is flat non-stimulated；
(3) tar dyestuff: do not detect；
(4) heavy metal: less than 2ppm；
(5) pot-life: product has the shelf-life of more than 18 months.
Finally illustrating, above example is only in order to illustrate technical scheme and unrestricted, and this area is common
Other amendment or equivalents that technical scheme is made by technical staff, without departing from technical solution of the present invention
Spirit and scope, all should contain in the middle of scope of the presently claimed invention.
Claims (10)
1. the health care instant containing Folium clausenae lansii, it is characterised in that by weight, including following components: dry Clausena lansium (Lour.) Skeels
Leaf 5-15 part, Radix Astragali 1-3 part, Poria 1-3 part, 0.8-1.5 part Radix Ophiopogonis, Radix Glycyrrhizae 1-2.5 part, fresh Rhizoma Phragmitis 2-5 part, Flos Lonicerae 1.5-
3 parts, Fructus Crataegi 1-2 part, Bulbus Fritillariae Cirrhosae 0.3-0.8 part, Fructus Momordicae 1.5-3 part, Mel 3-5 part, pigment 0.3-0.8 part, one, seven leaf
Flower 0.2-1 part, Rhizoma Polygonati Odorati 2-3 part.
A kind of health care instant containing Folium clausenae lansii the most according to claim 1, it is characterised in that a kind of containing Clausena lansium (Lour.) Skeels
The health care instant of leaf, by weight, including following components: dry Folium clausenae lansii 12 parts, the Radix Astragali 2 parts, 2.5 parts of Poria, Radix Ophiopogonis
1.2 parts, 1.8 parts of Radix Glycyrrhizae, fresh Rhizoma Phragmitis 4 parts, Flos Lonicerae 2.4 parts, Fructus Crataegi 1.5 parts, Bulbus Fritillariae Cirrhosae 0.6 part, Fructus Momordicae 2.5 parts, Mel
4.5 parts, pigment 0.5 part, Rhizoma Paridis 0.8 part, Rhizoma Polygonati Odorati 2.5 parts.
A kind of health care instant containing Folium clausenae lansii the most according to claim 1, it is characterised in that described pigment is sky
So pigment, described pigment is caramel color, annatto pigment, monascorubin, Gardenia Yellow or capsicum red pigment.
4. the preparation method of the health care instant containing Folium clausenae lansii, it is characterised in that it comprises the following steps:
(1) by dry Folium clausenae lansii shredding；By the Radix Astragali, Poria, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Crataegi, Rhizoma Polygonati Odorati section；By Bulbus Fritillariae Cirrhosae, Fructus Momordicae pressure
Broken；Fresh Rhizoma Phragmitis is squeezed the juice filtration, prepare fresh reed juice；
(2) dry Folium clausenae lansii, Flos Lonicerae, Rhizoma Paridis being placed in pot, add the solution of 15-30 part, solution is water, uses heat
Reflux technique extracts 3-5h, maintains the temperature at 85-100 DEG C, is filtrated to get solution A after natural cooling；
(3) Radix Astragali, Poria, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Crataegi, Bulbus Fritillariae Cirrhosae, Fructus Momordicae are placed in pot, add 25-50 part solution, solution
For water, use thermal reflux to extract 4-6h, maintain the temperature at 85-100 DEG C, naturally cool to 30-40 DEG C and add Mel, natural
Cooled and filtered obtains solution B；
(4) fresh reed juice, solution A, solution B are mixed, stir；
(5) add pigment as required, stir, obtain solution C；
(6) use concentration technology that solution C is concentrated, obtain concentrated solution D；
(7) use drying process that concentrated solution D is dried, obtain solid matter E；
(8) using pulverizer to pulverize solid matter E, obtain granule F, after pulverizing, the particle diameter of granule F is 60-120 mesh；
(9) filling machine is used to be filled in container by granule F.
The preparation method of a kind of health care instant containing Folium clausenae lansii the most according to claim 4, it is characterised in that step
Suddenly, in (2) and step (3), described thermal reflux coordinates microwave extraction technology or ultrasonic wave extraction to make in practical operation
With.
The preparation method of a kind of health care instant containing Folium clausenae lansii the most according to claim 4, it is characterised in that step
Suddenly, in (6), described concentration technology is membrance concentration technology.
The preparation method of a kind of health care instant containing Folium clausenae lansii the most according to claim 4, it is characterised in that step
Suddenly, in (7), described drying process is spray drying technology.
The preparation method of a kind of health care instant containing Folium clausenae lansii the most according to claim 4, it is characterised in that step
Suddenly, in (7), the water content of described solid matter E is less than 1%.
The preparation method of a kind of health care instant containing Folium clausenae lansii the most according to claim 4, it is characterised in that step
Suddenly, in (9), described filling machine is aseptic filler.
The preparation method of a kind of health care instant containing Folium clausenae lansii the most according to claim 4, it is characterised in that
In step (9), described container is tank container or plastic bag.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101721607A (en) * | 2009-11-26 | 2010-06-09 | 申忠良 | Chinese medicinal beverage for body building and flu resistance |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101721607A (en) * | 2009-11-26 | 2010-06-09 | 申忠良 | Chinese medicinal beverage for body building and flu resistance |
Non-Patent Citations (1)
| Title |
|---|
| 黄桂红等: "黄皮叶萃取物镇咳、祛痰及平喘作用研究", 《天津医药》 * |
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Address after: Nansha District Fengze road Guangzhou city Guangdong province 511458 No. 106 X1301-B437 Applicant after: Guangzhou poly injection General Technology Research Institute Co Ltd Address before: Nansha District Fengze road Guangzhou city Guangdong province 511458 No. 106 X1301-B437 Applicant before: GUANGZHOU JUZHU PATENT RESEARCH AND DEVELOPMENT CO., LTD. |
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Application publication date: 20161116 |