CN106106511A - A kind of composition pesticide containing fosthiazate - Google Patents

A kind of composition pesticide containing fosthiazate Download PDF

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Publication number
CN106106511A
CN106106511A CN201610544379.1A CN201610544379A CN106106511A CN 106106511 A CN106106511 A CN 106106511A CN 201610544379 A CN201610544379 A CN 201610544379A CN 106106511 A CN106106511 A CN 106106511A
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fosthiazate
agent
tioxazafen
weight
parts
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CN201610544379.1A
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Inventor
王礼文
陈佛祥
张志伟
朱刚
吴泽伟
颜石雷
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Guangdong Zhongxun Agri Science Corp
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Guangdong Zhongxun Agri Science Corp
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/26—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-nitrogen bonds
    • A01N57/32—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-nitrogen bonds containing heterocyclic radicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A01N25/28—Microcapsules or nanocapsules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses a kind of containing fosthiazate with the composition pesticide of tioxazafen, including usual auxiliaries, fosthiazate and tioxazafen, fosthiazate is 20:1～1:20 with the ratio of weight and number of tioxazafen；Fosthiazate and with tioxazafen with certain compounding after nematicide had obvious synergism, it is adaptable to the crop nematicide that preventing and treating pathogen nematicide causes, especially root of the crop Root-knot and cyst nematode disease.

Description

A kind of composition pesticide containing fosthiazate
Technical field
The composition pesticide that the present invention relates to, is that compositions is to cause of disease with fosthiazate and tioxazafen as effective ingredient Nematicide Meloidogyne incognita and soybean cyst nematode Heterodera glycines and the crop nematicide caused thereof have synergistic function, it is adaptable to preventing and treating By the crop nematicide of pathogen nematicide, root of the crop Root-knot that especially Meloidogyne incognita causes and soy bean cyst roundworm The crop Cyst nematode caused.
Background technology
Fosthiazate (fosthiazate), for organophosphor nematicide.Model of action is the acetylcholine ester of suppression insect Enzyme, has good interior absorption, is mainly used in preventing and treating nematicide, aphid etc., and quick-acting is good, and the lasting period is long, and fosthiazate uses latter 2 months In rear soil, fosthiazate remains to reach root-knot nematode lethasl concentration, remains to reduce nematicide movable after 3 months.
Tioxazafen, chemical name: 3-phenyl-5-(thiophene-2-base)-1,2,4-diazole.Meng Shan opens for 2008 The non-stifling property nematicide sent out, because it is more environmentally friendly, it is safer to use, less on the impact of people, is described as the ideal of fosthiazate Succedaneum, greenhouse and field experiment show, the performance of this novel nematicide is produced equivalent to or better than the comparison of current commercialization Product.It is reported, tioxazafen is to the soybean cyst nematode Heterodera glycines on Semen sojae atricolor, root-knot nematode, kidney shape nematicide, the root-rot line on Semen Maydis Worm, root-knot nematode, minute hand nematicide, kidney shape nematicide on Cotton Gossypii, root-knot nematode etc. are respectively provided with fabulous biological activity.
Plant nematode is the pathogenic microorganism that a class is very harmful, and it has a very wide distribution, of a great variety, environment adaptation Ability is strong, can colonize in the root system of plant, stem, leaf, seed, plumelet and fruit, can be by feeding activity to host plant Cause mechanical damage, and rob the nutrition of host plant, especially its esophageal gland secretions can cause host plant occur one be Epidemy becomes, and also can jointly infect host plant with other pathogenic microorganism, cause compound disease, cause production loss.In the whole world In the range of, the agricultural losses that plant nematode is caused every year are up to more than 100,000,000,000 dollars, seriously constrain agricultural economy Development.
Being found by experiment that, fosthiazate and tioxazafen are used in mixed way black to Meloidogyne incognita with soybean cyst nematode Heterodera glycines Deng plant pathogeny line insect have synergistic function especially in 20:1～1:20 proportion to Meloidogyne incognita and big Bean Cyst nematode has obvious potentiation, and preferred weight ratio is 6:1～1:6, and more excellent part by weight is 3:1～1:3.
Can be the dosage form agriculturally commonly used with excipient by certain technological means fosthiazate and tioxazafen compositions Such as granule, aqueous emulsion, micro-capsule suspension, the popularization and application of the present invention that is more convenient for after excipient.
Summary of the invention
It is an object of the invention to provide the synergetic pesticide composition that a kind of effective ingredient is fosthiazate and tioxazafen, Prevention and control for crop nematicide especially provide one effectively to manage instrument for root of the crop Root-knot and Cyst nematode.
The present invention is achieved through the following technical solutions:
The present invention relates to a kind of synergistic composition compounding containing fosthiazate and tioxazafen, fosthiazate with The part by weight of tioxazafen is 20:1～1:20, and preferred weight ratio is 6:1～1:6, and more excellent part by weight is 3:1～1: 3。
Described composition pesticide effective ingredient total content is 0.1%～60%.
Described microbicide compositions add auxiliary agent and excipient by certain technological means make granule, aqueous emulsion, The dosage form that micro-capsule suspension etc. are agriculturally conventional.
Described granule dosage form weight percent consists of: fosthiazate 0.1～30%, tioxazafen0.1～30%, Dispersant 0.1～15%, wetting agent 0.1～10%, binding agent 0.1～14%, carrier complement to 100%.Concrete production stage For: concrete production stage is: by effective ingredient and other auxiliary agent mix homogeneously, pulverize with micro jet, through mediating, so Rear addition fluidized-bed granulation dryer carries out pelletize, dry, screening, prepares the granule of corresponding weight percentage.
Described aqueous emulsion agent weight percent consists of: fosthiazate 0.1～30%, tioxazafen0.1～30%, Dispersant 0.1～13%, emulsifying agent 0.1～13%, thickening agent 0.1～3%, antifreezing agent 0.1～5%, stabilizer 0.1～5%, Deionized water complements to 100%.Concrete production stage is: effective ingredient and other auxiliary agent is mixed, divides through high speed shear emulsifying After Saning, preparing the aqueous emulsion of corresponding weight percentage, described aqueous emulsion Active principals is not higher than 40%.
Described micro-capsule suspension dosage form weight percent consists of: fosthiazate 0.1～30%, tioxazafen0.1 ～30%, capsule-core solvent 0.1～15%, oiliness cyst material 0.1～15%, aqueous cyst material 0.1～12%, emulsifying agent 0.1～6%, dispersant 0.1～5%, antifreezing agent 0.1～3%, thickening agent 0.1～2%, pH adjusting agent 0.1～2%, deionization Water complements to 100%.Concrete production stage is: fosthiazate and tioxazafen is dissolved in capsule-core solvent, adds emulsifying agent Stir, add oiliness cyst material, be uniformly mixed as oil phase；Aqueous cyst material and part thickening agent are added Water is stirred for aqueous phase；Oil phase and aqueous phase are mixed, shear by high-shear emulsion machine, form uniform emulsion, 28～ 35 DEG C are reacted 2～4 hours, are warmed up to 60～80 DEG C of resolidifications 1～4 hours, add remaining thickening agent and dispersant and anti- Freezing agent, regulation pH is neutral, supplies with deionized water, just can get the micro-capsule suspension of corresponding percentage composition, described micro-glue The total content of capsule suspending agent active component is not higher than 40%.
Described defoamer can be one or more in silicone compound, epoxy soybean oil, methanol, silicone oil etc..
Described antifreezing agent can be one or more in glycerol, propylene glycol, diethylene glycol, carbamide etc..
Described wetting agent can be sodium lauryl sulphate, dodecylbenzene sodium sulfonate, sodium butylnaphthalenesulfonate, alkyl sulphur In acid sodium, tea seed cake powder, spaonin powder, Fructus Sapindi Mukouossi powder etc. one or more, corn starch, sorghum starch, Fagopyrum esculentum Moench powder.
Described dispersant can be alkylphenol polyoxyethylene formaldehyde condensation products, naphthalenesulfonate formaldehyde condensation compound, to first Epoxide fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, alkylphenol polyoxyethylene sulfate, alkyl benzene sulphonate Calcium salt, fatty acid ester sulfate, alkylphenol polyoxyethylene, fatty alcohol-polyoxyethylene ether, polyglycol distearate, sorbose One or more in alcohol oleate, nekal etc., special dispersant can also is that a kind of combed metal carboxylate Terpolymer dispersants (BBM-3 hereinafter relates to all replacing of this terpolymer dispersants with BBM-3), this copolymer Come from patent application 201310521909.7, be a kind of with acrylic homolog, mono polyethylene glycol maleate, propylene Acid esters is monomer, with free-radical polymerized method synthesis in aqueous phase system, concrete, by the monomer group of following weight ratio Become: acrylate 10～50 parts, acrylic homolog 10～80 parts, mono polyethylene glycol maleate 10～50 parts, work Skill step is as follows: 1000 parts of distilled waters, 10 parts of surfactants is joined in four mouthfuls of reaction flasks, heats while stirring；When When the temperature of solution rises to 60 DEG C in reaction bulb, add 200 parts of acrylate, 500 parts of acrylic homolog, 100 parts of maleic acids Single poly glycol monomethyl ether ester and 30 parts of initiator solutions added in 1 hour, then 60 DEG C of insulation reaction 2 hours；Insulation reaction Being down to room temperature after end while stirring, with the carboxylic acid in sodium hydroxide solution and in system, dosis neutralisata is carboxyl molal quantity 50%, prepare destination scatter agent solution.
Described disintegrating agent can be carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, Polyvinylpolypyrrolidone, chitosan, sodium alginate sodium bicarbonate, magnesium chloride, aluminum chloride, sodium chloride, carbamide, ammonium sulfate, bentonite etc. In one or more.
Described thickening agent can be polyvinyl acetate, xanthan gum, gelatin, Radix Acaciae senegalis, aluminium-magnesium silicate, phenolic aldehyde tree One or more in fat, hydroxymethyl cellulose, sodium alginate etc..
Described solid carrier can be precipitated calcium carbonate, potter's clay, Kaolin, kieselguhr, bentonite, white carbon, clay, One or more in attapulgite, Pulvis Talci, quartz sand, wood powder, walnut parting, lignin, Testa Tritici, rice chaff, wood flour etc..
Described oiliness cyst material is selected from methyl diphenylene diisocyanate, hexamethylene diisocyanate, 4,4'-bis- One or more in diphenylmethane diisocyanate.
Described capsule-core solvent is selected from toluene, dimethylbenzene, solvent naphtha S-150, solvent naphtha S-200, ethanol, isopropanol, just Butanol, n-octyl alcohol, n-amyl alcohol, acetone, Ketohexamethylene, hexane, dimethylformamide, N-Methyl pyrrolidone, acetonitrile, dichloromethane One or more in alkane, ethyl acetate, methyl oleate, dibutyl phthalate.
Described aqueous cyst material one in ethylene glycol, glycerol, ethylenediamine, propane diamine, the third triamine, the water or Several.
Described emulsifying agent selected from agriculture breast 33#, agriculture breast 34#, agriculture breast 500#, agriculture breast 600#, Nongru-700 #, agriculture breast 1601#, Agriculture breast 1602#, T60, S80, TX-10, OP-10, NP-10, Nonyl pheno (EO=10) ether phosphate, triphenoethyl benzene One in phenol polyethenoxy ether phosphate, BBM-3, epoxychloropropane.
Described solvent is one or more in dimethylbenzene, ethylene glycol, benzoic acid, Ketohexamethylene, solvent naphtha.
Described pH adjusting agent one in acetic acid, sodium hydroxide.
Described deionized water is industrialization deionized water.
Described binding agent can be sucrose, polyvinyl alcohol, Polyethylene Glycol, sodium carboxymethyl cellulose, polyvinylpyrrolidine Ketone, carboxymethylcellulose calcium, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, viscosity Kaolin, paraffin, One or more in Colophonium, wood powder etc..
Composition pesticide of the present invention has significant synergistic function, is used alone than single dose and significantly improves agriculture The prevention effect of nematicide on crop；Decrease Pesticide use amount, reduce use cost, alleviate the pollution to environment.
Detailed description of the invention
In order to be more fully understood that the essence of the present invention, below in conjunction with embodiment, present disclosure is described further, But can not be considered as limitation of the present invention, the following stated is only used for explaining the present invention, for without departing from present invention spirit and principle The amendment made, replace or improve, belong to the scope of protection of present invention.
According to the abundant method of Sun Yun, evaluate the synergism of pharmacy mix, i.e. CTC≤80 according to co-toxicity coefficient (CTC) for association Same antagonism, 80 ＜ CTC ＜ 120 are joint action of antagonism, and CTC >=120 are synergistic function.Actual measurement toxicity index (ATI)=(EC of standard agent50The EC of/reagent agent50)×100；The toxicity index of theoretical toxicity index TTI=A medicament × The percentage composition of B medicament in the toxicity index × mixture of the percentage composition+B medicament of A medicament in mixture；Co-toxicity coefficient (CTC)= [mixture actual measurement toxicity index (ATI)/mixture theory toxicity index (TTI)] × 100.
Embodiment one: fosthiazate tioxazafen is to cloth Meloidogyne incognita (Meloidogyne incongnita Chitwood) Toxicity Determination, subjects is picked up from and is used the graceful funnel of shellfish to send out in the Cucumber root-knot nematode disease insect gall in field The Meloidogyne incognita (Meloidogyne incongnita Chitwood) separated.
Table 1, fosthiazate tioxazafen are to Meloidogyne incognita (Meloidogyne incongnita Chitwood) Toxicity Determination result
As shown in Table 1, fosthiazate and tioxazafen mixed ratio are between 20:1～1:20, to Meloidogyne incognita (Meloidogyne incongnita Chitwood) has obvious potentiation, and co-toxicity coefficient is all more than 140；Thiazole Phosphine and tioxazafen mixture between 6:1～1:6 to Meloidogyne incognita (Meloidogyne incongnita Chitwood) having obvious potentiation, co-toxicity coefficient is all more than 200；Fosthiazate and tioxazafen mixture at 3:1～ Between 1:3, Meloidogyne incognita (Meloidogyne incongnita Chitwood) had obvious potentiation, altogether poison Coefficient is all more than 220.
Embodiment two: fosthiazate tioxazafen is to soy bean cyst roundworm (Heterodera glycines Ichinohe) Toxicity Determination, subjects is picked up from and is used the graceful funnel of shellfish to send out in the soybean cyst nematode insect gall in field The soy bean cyst roundworm (Heterodera glycines Ichinohe) separated.
Table 2, fosthiazate tioxazafen are to soy bean cyst roundworm
The Toxicity Determination result of (Heterodera glycines Ichinohe)
As shown in Table 2, fosthiazate and tioxazafen mixed ratio are between 20:1～1:20, to soy bean cyst roundworm (Heterodera glycines Ichinohe) has obvious potentiation, and co-toxicity coefficient is all more than 150；Fosthiazate with Tioxazafen mixed ratio is between 6:1～1:6, to soy bean cyst roundworm (Heterodera glycines Ichinohe) Having obvious potentiation, co-toxicity coefficient is all more than 200；Fosthiazate and tioxazafen mixed ratio 3:1～1:3 it Between, soy bean cyst roundworm (Heterodera glycines Ichinohe) is had obvious potentiation, co-toxicity coefficient is equal More than 220.
Below in conjunction with preparation embodiment to further instruction of the present invention.
Evaluating synergistic method according to Gowing method, its formula is as follows:
E 0 = X + Y - X × Y 100
In formula:
X is fosthiazate with certain dosage prevention effect to water nemas time alone；
Y is tioxazafen with certain dosage prevention effect to nemas time alone；
E0For fosthiazate and tioxazafen with certain ratio mix to when using to the prevention effect of nemas Theoretical value or desired value；
E is that fosthiazate mixes the measured value to nemas prevention effect or observation with tioxazafen with certain ratio Value.
Evaluation criterion: as E E0During ＞ 10%, it is expressed as synergistic function；As 10%≤E E0When≤10%, performance For collaborative summation action；As E E0During ＜ 10%, show as joint action of antagonism.
Embodiment three: 30% fosthiazate tioxazafen micro-capsule suspension
Weigh the 20% former medicine of fosthiazate, the former medicine of 10%tioxazafen, be dissolved in 15%150# solvent naphtha, add 1.5% agriculture breast 33# and 7% methyl diphenylene diisocyanate, is uniformly mixed as oil phase；By 7% polyvinyl alcohol water solution Add in suitable quantity of water and be stirred for aqueous phase；Oil phase and aqueous phase are mixed, by high-shear emulsion machine under the conditions of 10000 turns every point Emulsification pretreatment, forms uniform emulsion, under 500 turns every point stirring the most uniformly drips 1% glycerol into emulsion, within 80 minutes, drip Add, react 4 hours under 25 DEG C of water-baths, 500 turns every point stirring, be warmed up to 60 DEG C and solidify 2 hours, add 2% xanthan gum Aqueous solution, 1% polycarboxylate salt dispersant and 4% ethylene glycol, regulation pH is neutral, supplies 100% weight portion with deionized water, i.e. Obtain 30% fosthiazate tioxazafen micro-capsule suspension.Identical technological process and auxiliary agent content is used to prepare 20% respectively Fosthiazate micro-capsule suspension and 10%tioxazafen micro-capsule suspension.After testing, envelop rate >=93%, particle diameter (0.45- 2.0 μm standard screens) >=95%, suspensibility >=90%, persistent foamability (after 1min)≤15mL, dispersibility >=90%, pH value 6.7-7.3, heat storage stability is qualified, and low-temperature stability is qualified.
Table 3, it is used for preventing and treating Cucumber root-knot nematode disease, Banana Root Root-knot, after medicine 60 days, E-E0It is all higher than 20%.
Embodiment four: 20% fosthiazate tioxazafen micro-capsule suspension
Weigh the 10% former medicine of fosthiazate, the former medicine of 10%tioxazafen, be dissolved in 15%150# solvent naphtha, add 2% Agriculture breast 33# and 5% methyl diphenylene diisocyanate, be uniformly mixed as oil phase；10% polyvinyl alcohol water solution is added Suitable quantity of water is stirred for aqueous phase；Oil phase and aqueous phase are mixed, shears under the conditions of 10000 turns every point by high-shear emulsion machine Emulsifying, forms uniform emulsion, under 500 turns every point stirring the most uniformly drips 1% ethylenediamine into emulsion, dropping in 40 minutes Complete, react 4 hours under 25 DEG C of water-baths, 500 turns every point stirring, be warmed up to 60 DEG C and solidify 2 hours, add 1% xanthan glue Solution, 2% polycarboxylate salt dispersant, 1% lignosulfonates and 4% ethylene glycol, regulation pH is neutral, supplies with deionized water 100% weight portion, just can get 20% fosthiazate tioxazafen micro-capsule suspension.Use identical technological process and help Agent content prepares 10% fosthiazate micro-capsule suspension and 10%tioxazafen micro-capsule suspension respectively.After testing, encapsulating Rate >=93%, particle diameter (0.45-2.0 μm standard screen) >=95%, suspensibility >=90%, persistent foamability (after 1min)≤15mL, Dispersibility >=90%, pH value 6.7-7.3, heat storage stability is qualified, and low-temperature stability is qualified.
Table 4, to be used for preventing and treating pepper root Root-knot, watermelon root-knot sick, after medicine 60 days, E-E0It is all higher than 20%.
Embodiment five: 24% fosthiazate tioxazafen micro-capsule suspension
Weigh the 6% former medicine of fosthiazate, the former medicine of 18%tioxazafen, be dissolved in 14%150# solvent naphtha, add 3.5% Agriculture breast 33# and 5% methyl diphenylene diisocyanate, be uniformly mixed as oil phase；15% polyvinyl alcohol water solution is added Suitable quantity of water is stirred for aqueous phase；Oil phase and aqueous phase are mixed, shears under the conditions of 10000 turns every point by high-shear emulsion machine Emulsifying, forms uniform emulsion, under 500 turns every point stirring the most uniformly drips 1% ethylenediamine into emulsion, dropping in 40 minutes Complete, react 4 hours under 25 DEG C of water-baths, 500 turns every point stirring, be warmed up to 60 DEG C and solidify 2 hours, add 1% xanthan glue Solution, 2% polycarboxylate salt dispersant, 1% lignosulfonates and 4% ethylene glycol, regulation pH is neutral, supplies with deionized water 100% weight portion, just can get 24% fosthiazate tioxazafen micro-capsule suspension.Use identical technological process and help Agent content prepares 6% fosthiazate micro-capsule suspension and 18%tioxazafen micro-capsule suspension respectively.After testing, envelop rate >=97%, particle diameter (0.45-2.0 μm standard screen) >=96%, suspensibility >=90%, persistent foamability (after 1min)≤13mL, point Dissipating property >=90%, pH value 6.8-7.2, heat storage stability is qualified, and low-temperature stability is qualified.
Table 5, it is used for preventing and treating soybean cyst nematode, Radix Melo Root-knot, after medicine 60 days, E-E0It is all higher than 20%.
Embodiment six: 20% fosthiazate tioxazafen aqueous emulsion
Weigh 15% fosthiazate, 5%tioxazafen, 12% agriculture breast 2201#, 10%BBM-3,1% epoxychloropropane, 2% ethylene glycol, 5% dimethylbenzene, 0.3% xanthan gum, 0.5% benzoic acid, surplus is deionized water.Above-mentioned raw materials is blended, high It is 20% fosthiazate tioxazafen aqueous emulsion that speed emulsification pretreatment prepares effective ingredient.Use identical technological process and auxiliary agent Content prepares 15% Fosthiazate aqueous emulsion and 5%tioxazafen aqueous emulsion.
Table 6, it is used for preventing and treating Kidney bean cyst nematode disease, Fructus psidii guajavae immaturus root knot nematode disease, after medicine 60 days, E-E0It is all higher than 20%.
Embodiment seven: 20% fosthiazate tioxazafen aqueous emulsion
Weigh 10% fosthiazate, 10%tioxazafen, 15% agriculture breast 2201#, 11%BBM-3,1.5% epoxy chloropropionate Alkane, 1% ethylene glycol, 5% dimethylbenzene, 0.3% xanthan gum, 0.5% benzoic acid, surplus is deionized water.Above-mentioned raw materials is blended, It is 20% fosthiazate tioxazafen aqueous emulsion that high speed shear emulsifying prepares effective ingredient.Use identical technological process and help Agent content prepares 10% Fosthiazate aqueous emulsion and 10%tioxazafen aqueous emulsion.
Table 7, it is used for preventing and treating hami melon root knot nematode disease, groundnut root knot nematode disease, after medicine 60 days, E-E0It is all higher than 20%.
Embodiment eight: 20% fosthiazate tioxazafen aqueous emulsion
Weigh 5% fosthiazate, 15%tioxazafen, 15% agriculture breast 2201#, 12%BBM-3,2% epoxychloropropane, 1% ethylene glycol, 5% dimethylbenzene, 0.1% xanthan gum, 0.5% benzoic acid, surplus is deionized water.Above-mentioned raw materials is blended, high It is 20% fosthiazate tioxazafen aqueous emulsion that speed emulsification pretreatment prepares effective ingredient.Use identical technological process and auxiliary agent Content prepares 5% Fosthiazate aqueous emulsion and 15%tioxazafen aqueous emulsion.
Table 8, it is used for preventing and treating Rhizoma Solani tuber osi root knot nematode disease, Semen vignae sinensis Cyst nematode, after medicine 60 days, E-E0It is all higher than 20%.
Embodiment nine: 10% fosthiazate tioxazafen granule
Weigh 8% fosthiazate, 2%tioxazafen, 5% sodium lignin sulfonate, 5% polyvinylpyrrolidone, 4% Fructus Vitis viniferae Sugar, 5% corn starch, 2% rice chaff, surplus attapulgite.Above-mentioned raw materials is mix homogeneously in mixed cylinder, through extruding, pelletize, It is dried, and screened step prepares 10% fosthiazate tioxazafen granule, uses identical technique and auxiliary agent content 8% Fosthiazate granule and 2%tioxazafen granule.
Table 9, it is used for preventing and treating that horse tomato root-knot eelworm is sick, Radix Chaenomelis Root-knot, after medicine 60 days, E-E0It is all higher than 20%.
Embodiment ten: 15% fosthiazate tioxazafen granule
Weigh 10% fosthiazate, 5%tioxazafen, 8% sodium lignin sulfonate, 7% polyvinylpyrrolidone, 5% Portugal Grape sugar, 4% corn starch, 4% rice chaff, surplus attapulgite.Above-mentioned raw materials is mix homogeneously in mixed cylinder, through extruding, makes Grain, it is dried, and screened step prepares 15% fosthiazate tioxazafen granule, uses identical technique and auxiliary agent content 10% fosthiazate granule and 5%tioxazafen granule.
Table 10, it is used for preventing and treating that horse tomato root-knot eelworm is sick, Radix Chaenomelis Root-knot, after medicine 60 days, E-E0It is all higher than 20%.
Embodiment 11: 12% fosthiazate tioxazafen granule
Weigh 4% fosthiazate, 8%tioxazafen, 7% sodium lignin sulfonate, 5% polyvinylpyrrolidone, 6% Fructus Vitis viniferae Sugar, 4% corn starch, 3% rice chaff, surplus attapulgite.Above-mentioned raw materials is mix homogeneously in mixed cylinder, through extruding, pelletize, It is dried, and screened step prepares 12% fosthiazate tioxazafen granule.Use identical technique and auxiliary agent content 4% Fosthiazate granule and 8%tioxazafen granule.
Table 11, it is used for preventing and treating Citrus root knot nematode disease, Radix Jujubae Root-knot, after medicine 60 days, E-E0It is all higher than 20%.

Claims (10)

1. the composition pesticide containing fosthiazate, it is characterised in that: effective ingredient is fosthiazate and tioxazafen.
A kind of composition pesticide containing fosthiazate the most according to claim 1, it is characterised in that: fosthiazate and The part by weight of tioxazafen is 20:1～1:20.
A kind of composition pesticide containing fosthiazate the most according to claim 1, it is characterised in that: fosthiazate and The part by weight of tioxazafen is 6:1～1:6.
A kind of composition pesticide containing fosthiazate the most according to claim 1, it is characterised in that: fosthiazate and The part by weight of tioxazafen is 3:1～1:3.
A kind of composition pesticide containing fosthiazate the most according to claim 1, it is characterised in that: the weight of effective ingredient Summation percentage by weight in the composition is 0.1%～60%, and remaining is insecticides adjuvant.
A kind of composition pesticide containing fosthiazate the most according to claim 5, it is characterised in that: the agent of described compositions Type is granule, aqueous emulsion, micro-capsule suspension.
Micro-capsule suspension the most according to claim 6, it is characterised in that each components by weight is: fosthiazate 0.1～ 20%, tioxazafen0.1～20%, capsule-core solvent 0.1～15%, oiliness cyst material 0.1～15%, aqueous cyst material 0.1～12%, emulsifying agent 0.1～6%, dispersant 0.1～5%, antifreezing agent 0.1～3%, thickening agent 0.1～2%, pH regulator Agent 0.1～2%, deionized water complement to 100%；
Concrete production stage is: fosthiazate and tioxazafen are dissolved in capsule-core solvent, adds emulsifier for mixing uniformly, then Add oiliness cyst material, be uniformly mixed as oil phase；Aqueous cyst material and part thickening agent are added to the water stirring all Even for aqueous phase；Oil phase and aqueous phase are mixed, shear by high-shear emulsion machine, form uniform emulsion, 28～35 DEG C of reactions 2～ 4 hours, it is warmed up to 60～80 DEG C of resolidifications 1～4 hours, adds remaining thickening agent and dispersant and antifreezing agent, regulate pH For neutrality, supply with deionized water, just can get the micro-capsule suspension of corresponding percentage composition, described micro-capsule suspension activity The total content of composition is not higher than 40%.
A kind of composition pesticide containing fosthiazate the most according to claim 6, it is characterised in that each composition weight percentage Ratio is: fosthiazate 0.1～30%, tioxazafen0.1～30%, dispersant 0.1～13%, emulsifying agent 0.1～13%, thickening Agent 0.1～3%, antifreezing agent 0.1～5%, stabilizer 0.1～5%, deionized water complement to 100%；
Concrete production stage is: effective ingredient and other auxiliary agent are mixed, and after high speed shear emulsion dispersion, prepares corresponding weight The aqueous emulsion of percentage composition, described aqueous emulsion Active principals is not higher than 40%；
Described dispersant is combed metal carboxylate terpolymer (BBM-3), is made up of the monomer of following weight ratio: acrylic acid Ester 10～50 parts, acrylic homolog 10～80 parts, mono polyethylene glycol maleate 10～50 parts, above proportioning is attached most importance to Amount part, three's sum is 100 parts；
Described combed metal carboxylate terpolymer (BBM-3) is prepared by the following method: by 1000 parts of distilled waters, 10 parts of surfaces Activating agent joins in four mouthfuls of reaction flasks, heats while stirring；When in reaction bulb, the temperature of solution rises to 60 DEG C, add 200 parts of acrylate, 500 parts of acrylic homolog, 100 parts of mono polyethylene glycol maleates and 30 parts of initiator solutions Add in 1 hour, then 60 DEG C of insulation reaction 2 hours；Insulation reaction is down to room temperature after terminating while stirring, molten with sodium hydroxide Carboxylic acid in liquid and in system, dosis neutralisata is the 50% of carboxyl molal quantity, prepares destination scatter agent solution.
A kind of composition pesticide containing fosthiazate the most according to claim 6, it is characterised in that the weight hundred of each component Proportion by subtraction is: fosthiazate 0.1～30%, tioxazafen0.1～30%, dispersant 0.1～15%, wetting agent 0.1～10%, viscous Knot agent 0.1～14%, carrier complement to 100%；
Concrete production stage is: concrete production stage is: by effective ingredient and other auxiliary agent mix homogeneously, use ultra micro comminution by gas stream Machine is pulverized, and through mediating, is subsequently adding in fluidized-bed granulation dryer and carries out pelletize, dry, screening, prepare corresponding weight percent and contain The granule of amount.
10. a kind of composition pesticide containing fosthiazate described in any one of claim 1 to 9 is being prevented and treated by Meloidogyne incognita The application on crop Cyst nematode that the root of the crop Root-knot caused and soy bean cyst roundworm cause.
CN201610544379.1A 2016-07-08 2016-07-08 A kind of composition pesticide containing fosthiazate Pending CN106106511A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106962372A (en) * 2017-03-20 2017-07-21 佛山市普尔玛农化有限公司 A kind of the pyridine acid amides of miaow containing trifluoro and Tioxazafen kill line composition
CN107183048A (en) * 2017-06-01 2017-09-22 华北制药集团爱诺有限公司 A kind of nematicidal composition containing chlopyrifos and Tioxazafen
CN110506742A (en) * 2019-09-23 2019-11-29 河北军星生物化工有限公司 A kind of fosthiazate water-soluble granula and preparation method thereof containing stabilizer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104587891A (en) * 2013-10-30 2015-05-06 上海是大高分子材料有限公司 Comb type carboxylate ternary copolymer and preparation technology thereof
CN104936451A (en) * 2012-12-04 2015-09-23 孟山都技术公司 Nematicidal aqueous suspension concentrate compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104936451A (en) * 2012-12-04 2015-09-23 孟山都技术公司 Nematicidal aqueous suspension concentrate compositions
CN104587891A (en) * 2013-10-30 2015-05-06 上海是大高分子材料有限公司 Comb type carboxylate ternary copolymer and preparation technology thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106962372A (en) * 2017-03-20 2017-07-21 佛山市普尔玛农化有限公司 A kind of the pyridine acid amides of miaow containing trifluoro and Tioxazafen kill line composition
CN107183048A (en) * 2017-06-01 2017-09-22 华北制药集团爱诺有限公司 A kind of nematicidal composition containing chlopyrifos and Tioxazafen
CN110506742A (en) * 2019-09-23 2019-11-29 河北军星生物化工有限公司 A kind of fosthiazate water-soluble granula and preparation method thereof containing stabilizer

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Application publication date: 20161116