CN106102775A - 治疗纤维变性疾病的方法 - Google Patents

治疗纤维变性疾病的方法 Download PDF

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Publication number
CN106102775A
CN106102775A CN201580007480.7A CN201580007480A CN106102775A CN 106102775 A CN106102775 A CN 106102775A CN 201580007480 A CN201580007480 A CN 201580007480A CN 106102775 A CN106102775 A CN 106102775A
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combination
modulator
fibrosis
gene
modulators
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CN201580007480.7A
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Chinese (zh)
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詹姆斯·阿普尔曼
佩吉·A·汤普森
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Effector Therapeutics Inc
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Effector Therapeutics Inc
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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CN201580007480.7A 2014-02-07 2015-02-07 治疗纤维变性疾病的方法 Pending CN106102775A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461937272P 2014-02-07 2014-02-07
US61/937,272 2014-02-07
US201462010004P 2014-06-10 2014-06-10
US62/010,004 2014-06-10
US201462037497P 2014-08-14 2014-08-14
US62/037,497 2014-08-14
PCT/US2015/014939 WO2015120350A2 (en) 2014-02-07 2015-02-07 Compositions and methods for treating fibrotic disease

Publications (1)

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CN106102775A true CN106102775A (zh) 2016-11-09

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CN201580007480.7A Pending CN106102775A (zh) 2014-02-07 2015-02-07 治疗纤维变性疾病的方法

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US (2) US9993494B2 (https=)
EP (1) EP3102703A2 (https=)
JP (1) JP2017510552A (https=)
CN (1) CN106102775A (https=)
AU (1) AU2015213721B2 (https=)
CA (1) CA2938592A1 (https=)
WO (1) WO2015120350A2 (https=)

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CN106983738A (zh) * 2017-04-13 2017-07-28 深圳市润佳通科技有限公司 甲状腺激素及其药学上可接受的盐或前药在制备治疗和/或预防皮肤疾病的药物中的应用
CN107260730A (zh) * 2017-05-31 2017-10-20 上海市东方医院 组蛋白去乙酰化酶hdac6的抑制剂在制备防治腹膜透析后腹膜纤维化的药物中的用途
CN107326093A (zh) * 2017-09-04 2017-11-07 东南大学 基于Taqman探针的慢性肾脏病相关基因检测荧光定量PCR一步法试剂盒及其应用
CN107916254A (zh) * 2017-11-29 2018-04-17 武汉大学 Homer1单克隆抗体及其应用
CN108192984A (zh) * 2018-02-13 2018-06-22 浙江大学 与湖羊肉质性状相关的分子标记及特异性引物对和应用
CN111228464A (zh) * 2020-02-28 2020-06-05 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) 广谱抗冠状病毒的多肽及其用途
CN113679841A (zh) * 2020-05-19 2021-11-23 上海市同济医院 一种磷脂酶d1(pld1)基因及其抑制剂在肝纤维化防治中的应用
CN119925378A (zh) * 2023-11-03 2025-05-06 成都嘉葆药银医药科技有限公司 吡咯并三嗪类化合物在制备预防和/或治疗纤维化或其相关疾病的药物中的应用

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US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
WO2017189837A1 (en) * 2016-04-29 2017-11-02 The Trustees Of The University Of Pennsylvania Protein kinase rna-like endoplasmic reticulum kinase (perk) inhibitors for prevention and/or treatment of lung injury and/or inflammation
US10894960B2 (en) 2016-08-30 2021-01-19 Children's Hospital Medical Center Compositions and methods for nucleic acid transfer
CN109982693A (zh) 2016-09-22 2019-07-05 香港大学 细胞异常分化和isr相关疾病的预防和治疗方法
WO2018149978A1 (en) * 2017-02-16 2018-08-23 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. ALTERNATIVE ACTIVATION OF MACROPHAGES (M2 CELLS) THROUGH THE POLYAMINE-eIF5a-HYPUSINE AXIS
US12411144B2 (en) 2017-03-22 2025-09-09 Children's Hospital Medical Center Compositions and methods for treatment of lung function
CA3063563A1 (en) * 2017-05-24 2018-11-29 Effector Therapeutics, Inc. Compositions and methods for an improved antitumor immune response
EP3747438A1 (en) 2017-07-24 2020-12-09 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Treating pathological conditions by direct and indirect targeting of sirpa - cd47 interaction
EP3659609B1 (en) 2017-07-28 2024-05-08 Kyorin Pharmaceutical Co., Ltd. Therapeutic agent for fibrosis
WO2019180664A1 (en) * 2018-03-21 2019-09-26 The University Of Hong Kong Method for preventing or modulating fibrosis and fibrotic response associated with the integrated stress response
AU2020299362B2 (en) 2019-07-02 2026-02-26 Effector Therapeutics, Inc. EiF4e-inhibiting 4-OXO-3,4-dihydropyrido(3,4-d)pyrimidine compounds
KR102100163B1 (ko) 2019-09-24 2020-04-13 테고사이언스 (주) 켈로이드 또는 비후성 반흔 예방 또는 치료용 조성물
US20230181582A1 (en) 2020-05-22 2023-06-15 Qx Therapeutics Inc. Compositions and methods for treating lung injuries associated with viral infections
CA3180229A1 (en) * 2020-05-29 2021-12-02 Cathy A. Swindlehurst Biarylsulfonamides and pharmaceutical compositions thereof, and their use for treating fibrotic lung disease
EP4217378A4 (en) * 2020-10-08 2025-02-26 The Trustees Of Dartmouth College Methods and agents for treating, preventing, diagnosing, and evaluating therapy for fibrotic, autoimmune, and inflammatory conditions
CA3207882A1 (en) * 2021-01-15 2022-07-21 Children's Hospital Medical Center Methods for optimizing cftr-modulator therapy
GB202109534D0 (en) * 2021-07-01 2021-08-18 Anglia Ruskin Univ Higher Education Corporation Treatment of scarring
US20250090523A1 (en) * 2021-07-22 2025-03-20 Shanghai Synvida Biotechnology Co. Ltd. Pharmaceutical composition or drug kit for alleviating or treating fibrotic diseases, and use thereof
CN118804976A (zh) * 2021-12-17 2024-10-18 雷杰纳荣制药公司 用整联蛋白亚基α1(ITGA1)抑制剂治疗肺部疾患
CN115558712B (zh) * 2022-09-22 2026-03-24 华中科技大学同济医学院附属协和医院 Fam177a1的新用途
CN117281906A (zh) * 2023-10-18 2023-12-26 浙江大学 Csrnp1抑制剂在制备治疗肝脏缺血再灌注损伤药物中的应用
CN117589999A (zh) * 2023-11-17 2024-02-23 深圳市人民医院 Pfkp作为慢性肾脏疾病治疗靶点的应用及其抑制剂
EP4714443A1 (en) * 2024-09-19 2026-03-25 Fundación Pública Galega Instituto de Investigación Sanitaria de Santiago de Compostela Heme-regulated inhibitor kinase activators for the treatment of neurological disorders
CN120789266A (zh) * 2025-09-10 2025-10-17 山东第一医科大学第一附属医院(山东省千佛山医院) Eif3a抑制剂在制备治疗肝纤维化药物中的应用

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