CN106074889A - A kind of ginseng pills of sea dog - Google Patents
A kind of ginseng pills of sea dog Download PDFInfo
- Publication number
- CN106074889A CN106074889A CN201610531113.3A CN201610531113A CN106074889A CN 106074889 A CN106074889 A CN 106074889A CN 201610531113 A CN201610531113 A CN 201610531113A CN 106074889 A CN106074889 A CN 106074889A
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- CN
- China
- Prior art keywords
- ginseng
- ethanol
- radix
- standby
- herba epimedii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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Abstract
The present invention mainly belongs to health product technology field, it is specifically related to a kind of ginseng pills of sea dog, the weight portion meter of this each component of ginseng pills of sea dog: fur seal fine powder 30 40, Fructus Lycii 70 80, Radix Ginseng 70 80, Radix Codonopsis 50 60, Herba Epimedii 30 40, Semen Vitis viniferae 30 40, the Radix Astragali 30 40, the Cortex Eucommiae 50 60, dietary fiber 10 20, Mel 20 30, Pulvis Talci 200 220, Arabic tree powder 10 20.Owing to using technique scheme, inventive formulation is reasonable, has yin-nourishing yang-strengthening kidney-replenishing, adjusts endocrine；Blood yiqi；Bone and muscle strengthening；Antifatigue effect；Memory reinforcing, regulates neurasthenia；Protection prostate, improves prostatic function；Warming the kidney, benefit god, benefiting essence and marrow；Warming the interior benefit fire, strengthening spleen and middle warmer, mind tranquilizing and the heart calming, and preparation technology is simple, has no side effect, centering, elderly population are effective especially, thus expand range.
Description
Technical field
The present invention mainly belongs to health product technology field, is specifically related to one and has yin-nourishing yang-strengthening kidney-replenishing, adjusts endocrine；Mend
Blood QI invigorating；Bone and muscle strengthening；The ginseng pills of sea dog of antifatigue effect.
Background technology
According to of World Health Organization (WHO), the survey showed that, and the people of whole world true health only accounts for 5%, examines through doctor
Looking into, diagnose ill people and the most only account for 20%, the people of 75% is in sub-health state.Visible, subhealth state problem the most seriously perplexs
Work and the life of people.According to experts' analysis, disease and the sub-health state of more than 85% all has with body immunity decline
Close, think simultaneously and have purpose, suitable taking to have the health food regulating immune function, to eliminating or avoiding sub-health state
It is highly beneficial.
The formula of the existing similar products with antifatigue effect of existing market is fur seal, Fructus Lycii, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, silkworm
Pupa, Cortex Cinnamomi, its anti-fatigue effect composition is crude polysaccharides, and this functional component is mainly contained in Fructus Lycii, and lycium barbarum polysaccharide is in zoopery
Middle dosage is 0.1-0.5mg/kg
Time to resisting fatigue with to improve immunity notable, but when dosage increases to 1-10 mg/kg, this effect gradually subtracts
Weak, show " excess depression effect ", illustrate that the deficiency of this formula is its limited use in terms of resisting fatigue, when taking
Doses is to act on the most not substantially, in increasingly competitive today, no longer can meet people's need to anti-fatigue product
Ask.
Summary of the invention
In order to solve the problems referred to above, it is an object of the invention to provide a kind of preparation technology simple, formula is simple, has YIN nourishing
Strengthening yang and invigorating kidney, adjusts endocrine；Blood yiqi；Bone and muscle strengthening；Antifatigue effect, avoids the occurrence of " excess depression effect " simultaneously
Ginseng pills of sea dog.
The technical scheme is that a kind of ginseng pills of sea dog, the weight portion meter of this each component of ginseng pills of sea dog:
Fur seal fine powder 30-40 part, Fructus Lycii 70-80 part, Radix Ginseng 70-80 part, Radix Codonopsis 50-60 part, Herba Epimedii 30--40 part, Fructus Vitis viniferae
Seed 30-40 part, Radix Astragali 30-40 part, Cortex Eucommiae 50-60 part, dietary fiber 10-20 part, Mel 20-30 part, Pulvis Talci 200-220
Part, Arabic tree powder 10-20 part.
Further, this ginseng pills of sea dog also includes that invigorating the spleen and replenishing QI compositions, the weight portion of described QI invigorating compositions are 60-
70。
Further, the weight portion of each component of described invigorating middle warmer compositions is: Rhizoma Atractylodis Macrocephalae 5-7 part, Poria 6-8 part, Pericarpium Citri Reticulatae 3-5
Part, Radix Angelicae Sinensis part 6-8, Rhizoma Cimicifugae 5-6 part, Radix Bupleuri 8-10 part, Radix Glycyrrhizae Preparata 6-8 part, Rhizoma Zingiberis Recens 3-4 part, Fructus Jujubae 5-8 part.
Further, in described ginseng pills of sea dog:
Fur seal fine powder 35, Fructus Lycii 75, Radix Ginseng 75, Radix Codonopsis 55, Herba Epimedii 35, Semen Vitis viniferae 35, the Radix Astragali 35, the Cortex Eucommiae 55, meals are fine
Dimension 15, Mel 25, Pulvis Talci 210, Arabic tree powder 15.
Further, the weight portion meter of this each component of ginseng pills of sea dog:
Fur seal fine powder 30, Fructus Lycii 80, Radix Ginseng 70, Radix Codonopsis 50, Herba Epimedii 30, Semen Vitis viniferae 40, the Radix Astragali 30, the Cortex Eucommiae 60, meals are fine
Dimension 20, Mel 28, Pulvis Talci 215, Arabic tree powder 18.
Further, the weight portion meter of this each component of ginseng pills of sea dog:
Fur seal fine powder 40, Fructus Lycii 70, Radix Ginseng 80, Radix Codonopsis 60, Herba Epimedii 40, Semen Vitis viniferae 30, the Radix Astragali 40, the Cortex Eucommiae 50, meals are fine
Dimension 10, Mel 20, Pulvis Talci 200, Arabic tree powder 10.
Further, the weight portion meter of this each component of ginseng pills of sea dog:
Fur seal fine powder 40 parts, Fructus Lycii 80 parts, Radix Ginseng 80 parts, Radix Codonopsis 60 parts, Herba Epimedii 38 parts, Semen Vitis viniferae 34 parts, the Radix Astragali 36 parts,
The Cortex Eucommiae 57 parts, dietary fiber 18 parts, Mel 26 parts, Pulvis Talci 205 parts, Arabic 11 parts of powder of tree, invigorating the spleen and replenishing QI compositions 75 parts.
It is a further object of the present invention to provide the preparation method of above-mentioned ginseng pills of sea dog, the method specifically include following step
Rapid:
Step 1: by Herba Epimedii and Radix Ginseng, clean, clean, be dried, weigh the most by weight, the excessive sheep obtained after processing respectively
Leaves of pulse plants total flavones and saponin extract, standby；
Step 2: Fructus Lycii, Radix Codonopsis, Semen Vitis viniferae, the Radix Astragali, Cortex Eucommiae crude drug are cleaned, clean, dry, pulverize into coarse powder, subsequently
Weigh by weight and add in extraction pot, adding the purified water of crude drug weight 10-11 times, being heated to boiling, decocting 3 little
Time, medicinal liquid is leached, obtains filtrate for the first time, standby；
Step 3: herb liquid extracts for the second time: in extraction pot, adds the purified water of crude drug weight 7-8 times, and is heated to
Boiling, decocts 1.5-1.8 hour, is leached by medicinal liquid, obtains second time filtrate, standby；
Step 4: herb liquid extracts for the third time: in extraction pot, adds the purified water of crude drug weight 4-6 times, is heated to boiling,
Decoct 1 hour, medicinal liquid is leached, obtain third time filtrate, standby；
Step 5: by first time standby for step 1 to 3, for the second time, for the third time filtrate be placed in container and be uniformly mixed, heavy
Form sediment, filter, obtain filtrate, standby；
Step 6: step 5 gained filtrate is concentrated with Chinese drug steaming device, is concentrated into 2/5ths of filtrate volume, obtains concentrated solution,
Standby；
Step 7: step 6 gained concentrated solution is added the ethanol of the content 95% of 1 times of weight, carries out precipitate with ethanol 72 hours, so
After by separation of ethanol, obtain for the first time fluid extract；The ethanol of the content 95% that first-class extractum is added 0.8 times of weight is carried out
Precipitate with ethanol 48 hours, is then peeled off ethanol, obtains second time fluid extract；Second time fluid extract is added the content of 0.7 times of weight
The ethanol of 95% carries out precipitate with ethanol 24 hours, the most again separation of ethanol, obtains fluid extract, standby；
Step 8: the most yellow by adding fur seal fine powder, Mel, ginsenoside Rg1 and Herba Epimedii in fluid extract standby for step 7 gained
Ketone, stirs；
Fluid extract sodium hydroxide adjustment pH value standby for step 8 gained to 4.8～5.5, is then existed by step 9
120 DEG C carry out high temperature sterilize 30 minutes, mix, according to the preparation technology system of pill with sucrose, Pulvis Talci, Arabic tree powder
For obtaining ginseng pills of sea dog.
Further, the ratio of described saponin extract and Herba Epimedii total flavones is 0.8-1:0.8-1.
Further, the Herba Epimedii total flavones purifying technique of the Herba Epimedii in described step 1 is, specifically includes following steps:
Step 1. pretreatment: after being pulverized by dried Herba Epimedii, obtain Herba Epimedii coarse powder；
Step 2. is extracted: use ethanol reflux extraction to extract Herba Epimedii coarse powder, it is thus achieved that crude extract；
Step 3. purification: described crude extract is configured to suspension according to solid-to-liquid ratio 1:10-15 distilled water, and regulates suspendible
The pH value of liquid is 3.2～3.8；Use power be 80-100W microwave heating to 20-30 DEG C, then suspension is centrifuged,
Take supernatant, be splined on macroporous adsorptive resins with the loading flow velocity of 1.0～3.0BV/h；Stand after absorption,
Then carry out eluting by the elution speed of 1.0～3.0BV/h, after being first washed till without muddiness with distilled water, then with 3～
5BV concentration is 40%～50% ethanol elution, collects 0.5～2.0BV interval eluent, is returned by described eluent
Receive ethanol, obtain extractum, by extractum in 40～60 DEG C of drying under reduced pressure to dry, obtain Herba Epimedii total flavones.
Further, the purifying technique of the Radix Ginseng in described step 1 is, specifically includes following steps:
Step 1: ginseng raw material is crushed to coarse powder, adds the alcohol solution dipping that volume fraction is 50～70%, solid-liquid
Ratio 1:10～1: 15kg/L, extraction takes 2～4 times, and each extraction time is 6～7min, after extracting solution stands
Filter, merging filtrate, through microwave decompression Distillation recovery ethanol, obtain Radix Ginseng total saponins crude product extractum；Add this extractum 5～
The water of 10 times of volumes, is heated to 70～80 DEG C, is incubated 1～3min, and filtrate removes liposoluble constituent therein with ether,
Extracting 2～3 times with water saturated butanol solution, microwave decompression distillation and concentration reclaims n-butyl alcohol, obtains Radix Ginseng total saponins again
Fine work extractum；
Step 2: Radix Ginseng total saponins fine work extractum is added the ethanol solution dilution that volume fraction is 10%, makes extractum quality and second
The ratio of alcoholic solution volume is 1:10～1:18kg/L, obtains diluent, and by macroporous adsorptive resins, eluent flow rate is
3mL/min, resolves with the ethanol solution that volume fraction is 40%, and ethanol volume used is the twice of diluent, obtains content big
In the protopanaxatriol ginsenoside eluent of 25%；Resolve with the ethanol solution that volume fraction is more than 80% again, ethanol used
Liquor capacity is the twice of diluent, obtains content panoxadiol's type saponin eluent more than 50%；
Step 3: in panoxadiol's type saponin eluent add acetic acid, make acetic acid volume fraction in eluent be 1%～
5%, it is 60～80 DEG C through temperature, the heating in water bath of time 1.5～2h, by macroporous adsorptive resins after reaction,
Wash acid ion with water and other is dissolved in the impurity of water, then with the ethanol solution parsing of volume fraction more than 80%, eluent
The ginsenoside extract containing Rg3 and Rh2 is obtained through microwave decompression distillation.
The pharmacological action of each composition:
Fur seal fine powder: tonifying YANG YIN nourishing, kidney-supplementing liver-boosting, endocrine regulation.Blood yiqi, bone and muscle strengthening.
Fructus Lycii: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.Control hepatic and renal YIN deficiency, the acid of waist knee joint
Soft, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quench one's thirst, seminal emission.
Radix Ginseng: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, Fructus Alpiniae Oxyphyllae of calming the nerves.Control that impairment caused by overstrain is deficient, dizziness and headache, sexual impotence, frequent micturition, women are collapsed
Leakage, the disease of all qi-blood-body fluid deficiencies.
Herba Epimedii: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture；
Climacteric hypertension.
Cortex Cinnamomi: complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Controlling decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is let out
Rushing down, empty sun is floating more.
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Controlling spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination itches, and vaginal bleeding during pregnancy is intended to
Fall, frequent fetal movement, hypertension.
Radix Codonopsis: property is put down, sweet in the mouth, micro-acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung.For deficiency of the spleen and lung, the heart of breathing hard
Throbbing with fear, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.
Dietary fiber: be a kind of can not by the carbohydrate of human consumption, but be the indispensable material of human body, claimed
" the seventh-largest nutrient " for the mankind contributes to enteral escherichia coli synthesis multivitamin.Cellulose proportion is little, and volume is big,
Gastrointestinal takes up space relatively big, make people have satietion, be conducive to fat-reducing.Cellulose volume is big, after feed can stimulating gastrointestinal road, make
Digestive juice secretion increases and strengthens with gastrointestinal motility, can prevent and treat the constipation of diabetes.HFD can pass through gastric emptying,
The intestinal transhipment time changes, soluble fiber forms the effects such as gel at enteral and makes the absorption of sugar slow down.Also can be by reducing intestinal
Hormone such as Gastric inhibitory polypeptide or glucagon are secreted；
Semen Vitis viniferae: extract its active ingredient (grasp seed procyanidins oligomer, english abbreviation OPC) through high-tech approach and be aided with dimension life
Element C is refined to be formed.Semen Vitis viniferae extract (OPC) is a kind of efficient free radical scavenger.In human body can be removed poisonous
Free radical, protection human cell tissue is exempted from by the oxidative damage of free radical, prevents the kinds more than 80 such as allergy, cancer, aging and oneself
The disease relevant by base.Vitamin C can reduce fragility and the permeability of blood capillary, corrects the pathological change of allergy, simultaneously
Also being free radical scavenging and antioxidant, coordinate Semen Vitis viniferae extract (OPC), to correcting, the effect such as allergy, body constitution is more notable.
Mankind's Typical allergic disease includes bronchial asthma.Due to human normal metabolic processes, smoking, edible fat and salt down
Fire-cure meat, be inflamed, some cancer therapy drug, sleeping pill, computer radiate, pesticide, Organic substance rot, air pollution, chemistry cause
Ozone etc. in cancer thing, air also can produce free radical.If free radical can not be got rid of in time, easily cause allergy, cancer
The disease that the kind more than 80 such as disease, aging is relevant with free radical.As: have a headache, feel giddy, thrombocytopenia, hypoimmunity, joint
Inflammation, cataract, retinitis, apoplexy, person of a serious nature may cause cancer.The defying age of Semen Vitis viniferae, antioxidant effect is non-
Chang Hao, it is 30-50 times of vitamin C and vitamin E.
Mel: in glucose, vitamin, magnesium, phosphorus, calcium etc. can nervous system regulation, hypnotic.Meanwhile, Mel
In the enzyme that contains and mineral, help to improve immunity.
The invention has the beneficial effects as follows: owing to using technique scheme, inventive formulation is reasonable, there is YIN nourishing and YANG strengthening and mend
Kidney, adjusts endocrine；Blood yiqi；Bone and muscle strengthening；Antifatigue effect；Memory reinforcing, regulates neurasthenia；Protection prostatitis
Gland, improves prostatic function；Warming the kidney, benefit god, benefiting essence and marrow；Warming the interior benefit fire, strengthening spleen and middle warmer, mind tranquilizing and the heart calming, and preparation technology
Simply, having no side effect, centering, elderly population are effective especially, thus expand range.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme is described further.
Embodiment 1:
Ginseng pills of sea dog, the weight portion meter of this each component of ginseng pills of sea dog:
Fur seal fine powder 35, Fructus Lycii 75, Radix Ginseng 75, Radix Codonopsis 55, Herba Epimedii 35, Semen Vitis viniferae 35, the Radix Astragali 35, the Cortex Eucommiae 55, meals are fine
Dimension 15, Mel 25, Pulvis Talci 210, Arabic tree powder 15.
Preparation technology is:
Step 1: by Herba Epimedii and Radix Ginseng, clean, clean, be dried, weigh the most by weight, the excessive sheep obtained after processing respectively
Leaves of pulse plants total flavones and ginsenoside, standby；
Step 2: Fructus Lycii, Radix Codonopsis, Semen Vitis viniferae, the Radix Astragali, Cortex Eucommiae crude drug are cleaned, clean, dry, pulverize into coarse powder, subsequently
Weigh by weight and add in extraction pot, adding the purified water of crude drug weight 10 times, being heated to boiling, decoct 3 hours,
Medicinal liquid is leached, obtains filtrate for the first time, standby；
Step 3: herb liquid extracts for the second time: in extraction pot, adds the purified water of crude drug weight 7 times, and is heated to
Boiling, decocts 1.5 hours, is leached by medicinal liquid, obtains second time filtrate, standby；
Step 4: herb liquid extracts for the third time: in extraction pot, adds the purified water of crude drug weight 5 times, is heated to boiling, decocts
Boil 1 hour, medicinal liquid is leached, obtain third time filtrate, standby；
Step 5: by first time standby for step 1 to 3, for the second time, for the third time filtrate be placed in container and be uniformly mixed, heavy
Form sediment, filter, obtain filtrate, standby；
Step 6: step 5 gained filtrate is concentrated with Chinese drug steaming device, is concentrated into 2/5ths of filtrate volume, obtains concentrated solution,
Standby；
Step 7: step 6 gained concentrated solution is added the ethanol of the content 95% of 1 times of weight, carries out precipitate with ethanol 72 hours, so
After by separation of ethanol, obtain for the first time fluid extract；The ethanol of the content 95% that first-class extractum is added 0.8 times of weight is carried out
Precipitate with ethanol 48 hours, is then peeled off ethanol, obtains second time fluid extract；Second time fluid extract is added the content of 0.7 times of weight
The ethanol of 95% carries out precipitate with ethanol 24 hours, the most again separation of ethanol, obtains fluid extract, standby；
Step 8: the Radix Ginseng that fur seal fine powder, dietary fiber and step 1 prepare will be added in fluid extract standby for step 7 gained
Saponin extract and Herba Epimedii total flavones, ginsenoside extract and Herba Epimedii total flavones ratio are 1:1, stir；
Step 9: by fluid extract sodium hydroxide adjustment pH value standby for step 8 gained to 4.8, then enter at 120 DEG C
Row high temperature sterilize 30 minutes, mixes with sucrose, Pulvis Talci, Arabic tree powder, prepares sea according to the preparation technology of pill
Canis familiaris L. Ginseng Bolus.
Embodiment 2:
Ginseng pills of sea dog, the weight portion meter of this each component of ginseng pills of sea dog:
Fur seal fine powder 30, Fructus Lycii 80, Radix Ginseng 70, Radix Codonopsis 50, Herba Epimedii 30, Semen Vitis viniferae 40, the Radix Astragali 30, the Cortex Eucommiae 60, meals are fine
Dimension 20, Mel 28, Pulvis Talci 215, Arabic tree powder 18.
Preparation technology is:
Step 1: by Herba Epimedii and Radix Ginseng, clean, clean, be dried, weigh the most by weight, the excessive sheep obtained after processing respectively
Leaves of pulse plants total flavones and ginsenoside, standby；
Step 2: Fructus Lycii, Radix Codonopsis, Semen Vitis viniferae, the Radix Astragali, Cortex Eucommiae crude drug are cleaned, clean, dry, pulverize into coarse powder, subsequently
Weigh by weight and add in extraction pot, adding the purified water of crude drug weight 10 times, being heated to boiling, decoct 3 hours,
Medicinal liquid is leached, obtains filtrate for the first time, standby；
Step 3: herb liquid extracts for the second time: in extraction pot, adds the purified water of crude drug weight 7 times, and is heated to
Boiling, decocts 1.8 hours, is leached by medicinal liquid, obtains second time filtrate, standby；
Step 4: herb liquid extracts for the third time: in extraction pot, adds the purified water of crude drug weight 5 times, is heated to boiling, decocts
Boil 1 hour, medicinal liquid is leached, obtain third time filtrate, standby；
Step 5: by first time standby for step 1 to 3, for the second time, for the third time filtrate be placed in container and be uniformly mixed, heavy
Form sediment, filter, obtain filtrate, standby；
Step 6: step 5 gained filtrate is concentrated with Chinese drug steaming device, is concentrated into 2/5ths of filtrate volume, obtains concentrated solution,
Standby；
Step 7: step 6 gained concentrated solution is added the ethanol of the content 95% of 1 times of weight, carries out precipitate with ethanol 72 hours, so
After by separation of ethanol, obtain for the first time fluid extract；The ethanol of the content 95% that first-class extractum is added 0.8 times of weight is carried out
Precipitate with ethanol 48 hours, is then peeled off ethanol, obtains second time fluid extract；Second time fluid extract is added the content of 0.7 times of weight
The ethanol of 95% carries out precipitate with ethanol 24 hours, the most again separation of ethanol, obtains fluid extract, standby；
Step 8: the Radix Ginseng that fur seal fine powder, dietary fiber and step 1 prepare will be added in fluid extract standby for step 7 gained
Saponin extract and Herba Epimedii total flavones, ginsenoside extract and Herba Epimedii total flavones ratio are 1:0.95, stir；
Fluid extract sodium hydroxide adjustment pH value standby for step 8 gained to 5.5, is then carried out by step 9 at 120 DEG C
High temperature sterilize 30 minutes, mixes with sucrose, Pulvis Talci, Arabic tree powder, prepares fur seal according to the preparation technology of pill
Ginseng Bolus.
Embodiment 3:
Ginseng pills of sea dog, the weight portion meter of this each component of ginseng pills of sea dog:
Fur seal fine powder 40, Fructus Lycii 70, Radix Ginseng 80, Radix Codonopsis 60, Herba Epimedii 40, Semen Vitis viniferae 30, the Radix Astragali 40, the Cortex Eucommiae 50, meals are fine
Dimension 10, Mel 20, Pulvis Talci 200, Arabic tree powder 10.
Preparation technology is:
Step 1: by Herba Epimedii and Radix Ginseng, clean, clean, be dried, weigh the most by weight, the excessive sheep obtained after processing respectively
Leaves of pulse plants total flavones and ginsenoside, standby；
Step 2: Fructus Lycii, Radix Codonopsis, Semen Vitis viniferae, the Radix Astragali, Cortex Eucommiae crude drug are cleaned, clean, dry, pulverize into coarse powder, subsequently
Weigh by weight and add in extraction pot, adding the purified water of crude drug weight 9 times, being heated to boiling, decoct 3 hours, will
Medicinal liquid leaches, and obtains filtrate for the first time, standby；
Step 3: herb liquid extracts for the second time: in extraction pot, adds the purified water of crude drug weight 7 times, and is heated to
Boiling, decocts 1.6 hours, is leached by medicinal liquid, obtains second time filtrate, standby；
Step 4: herb liquid extracts for the third time: in extraction pot, adds the purified water of crude drug weight 5 times, is heated to boiling, decocts
Boil 1 hour, medicinal liquid is leached, obtain third time filtrate, standby；
Step 5: by first time standby for step 1 to 3, for the second time, for the third time filtrate be placed in container and be uniformly mixed, heavy
Form sediment, filter, obtain filtrate, standby；
Step 6: step 5 gained filtrate is concentrated with Chinese drug steaming device, is concentrated into 2/5ths of filtrate volume, obtains concentrated solution,
Standby；
Step 7: step 6 gained concentrated solution is added the ethanol of the content 95% of 1 times of weight, carries out precipitate with ethanol 72 hours, so
After by separation of ethanol, obtain for the first time fluid extract；The ethanol of the content 95% that first-class extractum is added 0.8 times of weight is carried out
Precipitate with ethanol 48 hours, is then peeled off ethanol, obtains second time fluid extract；Second time fluid extract is added the content of 0.7 times of weight
The ethanol of 95% carries out precipitate with ethanol 24 hours, the most again separation of ethanol, obtains fluid extract, standby；
Step 8: the Radix Ginseng that fur seal fine powder, dietary fiber and step 1 prepare will be added in fluid extract standby for step 7 gained
Saponin extract and Herba Epimedii total flavones, ginsenoside extract and Herba Epimedii total flavones ratio are 0.92:1, stir；
Step 9: by fluid extract sodium hydroxide adjustment pH value standby for step 8 gained to 5.2, then enter at 120 DEG C
Row high temperature sterilize 30 minutes, mixes with Mel, Pulvis Talci, Arabic tree powder, prepares sea according to the preparation technology of pill
Canis familiaris L. Ginseng Bolus.
Embodiment 4:
Ginseng pills of sea dog, the weight portion meter of this each component of ginseng pills of sea dog:
Fur seal fine powder 40 parts, Fructus Lycii 80 parts, Radix Ginseng 80 parts, Radix Codonopsis 60 parts, Herba Epimedii 38 parts, Semen Vitis viniferae 34 parts, the Radix Astragali 36 parts,
The Cortex Eucommiae 57 parts, dietary fiber 18 parts, Mel 26 parts, Pulvis Talci 205 parts, Arabic 11 parts of powder of tree, invigorating the spleen and replenishing QI compositions 75 parts.
Its preparation technology is:
Step 1: by Herba Epimedii and Radix Ginseng, clean, clean, be dried, weigh the most by weight, the excessive sheep obtained after processing respectively
Leaves of pulse plants total flavones and ginsenoside, standby；
Step 2: Fructus Lycii, Radix Codonopsis, Semen Vitis viniferae, the Radix Astragali, Cortex Eucommiae crude drug are cleaned, clean, dry, pulverize into coarse powder, subsequently
Weigh by weight and add in extraction pot, adding the purified water of crude drug weight 10 times, being heated to boiling, decoct 3 hours,
Medicinal liquid is leached, obtains filtrate for the first time, standby；
Step 3: herb liquid extracts for the second time: in extraction pot, adds the purified water of crude drug weight 7 times, and is heated to
Boiling, decocts 1.8 hours, is leached by medicinal liquid, obtains second time filtrate, standby；
Step 4: herb liquid extracts for the third time: in extraction pot, adds the purified water of crude drug weight 5 times, is heated to boiling, decocts
Boil 1 hour, medicinal liquid is leached, obtain third time filtrate, standby；
Step 5: by first time standby for step 1 to 3, for the second time, for the third time filtrate be placed in container and be uniformly mixed, heavy
Form sediment, filter, obtain filtrate, standby；
Step 6: step 5 gained filtrate is concentrated with Chinese drug steaming device, is concentrated into 2/5ths of filtrate volume, obtains concentrated solution,
Standby；
Step 7: step 6 gained concentrated solution is added the ethanol of the content 95% of 1 times of weight, carries out precipitate with ethanol 72 hours, so
After by separation of ethanol, obtain for the first time fluid extract；The ethanol of the content 95% that first-class extractum is added 0.8 times of weight is carried out
Precipitate with ethanol 48 hours, is then peeled off ethanol, obtains second time fluid extract；Second time fluid extract is added the content of 0.7 times of weight
The ethanol of 95% carries out precipitate with ethanol 24 hours, the most again separation of ethanol, obtains fluid extract, standby；
Step 8: fur seal fine powder, dietary fiber, invigorating the spleen and replenishing QI compositions and step will be added in fluid extract standby for step 7 gained
1 ginsenoside extract prepared and Herba Epimedii total flavones, ginsenoside extract and Herba Epimedii total flavones ratio are 1:
0.84, stir；
Step 9: by fluid extract sodium hydroxide adjustment pH value standby for step 8 gained to 5.0, then enter at 120 DEG C
Row high temperature sterilize 30 minutes, mixes with sucrose, Pulvis Talci, Arabic tree powder, prepares sea according to the preparation technology of pill
Canis familiaris L. Ginseng Bolus.
Four, typical case:
Case 1 a: ××, man, 55 years old.Closely fatigue and weak, being irritable and getting angry easily occur without obvious inducement over the past half year, emotion is not
Stable, abdominal part distension, constipation, the disease such as insomnia, examine its tongue arteries and veins, enlarged tongue has greatly indentation, and thin fur is white and moist, and deep pulse is thin and delicate.Through healthy body
Inspection Non Apparent Abnormality, according to its symptom and physical examination result, it is determined that for " fatigability subhealth state ", then includes in as object of study, gives
It is intervened by pharmaceutical composition of the present invention, and dosage is 1 ball on the one, Intervention periodicity 6 weeks.After intervening 4 weeks, suffer from
The symptoms such as person's readme fatigue, being irritable and getting angry easily, abdominal part distension are substantially alleviated.Intervene after terminating, patient fatigue, emotional instability, abdomen
The symptoms such as swollen, insomnia disappear substantially, within after drug withdrawal 6 weeks, follow up a case by regular visits to it, and readme has no the malaise symptoms such as fatigue, patient's readme
The malaise symptoms such as fatigue, abdominal distention do not occur, are emotionally stable, tired complete incidence graph.
Case 2: Soviet Union's ××, man, 49 years old.There is weak, side of body rib distension discomfort without obvious cause before 10 years in patient, because of
Tired or unhappy time increase the weight of, increase the weight of because of tired conscious tired, the side of body rib distension discomfort of work the most over the past half year, operational forces not from
The heart, with dysphoria, emotional instability, energy declines, and abdominal distention is dilute when doing during stool, examines its tongue arteries and veins, and tongue is dark red, and fat have greatly
Indentation, tongue is the thickest greasy, stringy and rolling pulse.Through health examination Non Apparent Abnormality, according to its symptom and physical examination result, it is determined that for " fatigability
Subhealth state ", then to include in as object of study, give pharmaceutical composition of the present invention and it is intervened, dosage is one day one
Ball, Intervention periodicity 6 weeks.The symptoms such as after intervening 4 weeks, patient's readme is tired, side of body rib distension is uncomfortable are substantially alleviated.Intervention terminates
After, it is tired in readme, side of body rib distension is uncomfortable, stool time when doing the symptom such as dilute substantially disappear, after drug withdrawal 6 weeks, to its carry out with
Visiting, readme has no the malaise symptoms such as tired, after drug withdrawal 12 weeks, again follows up a case by regular visits to it, and readme fatigue, abdominal distention, side of body rib is swollen
Full discomfort etc. does not occurs, the mental status is good, it is possible to competent routine work, its tired complete incidence graph.
Case 3: Lee ×, man, 46 years old.There is fatigue and weak, inappetence, memory in cause work fatigue in 4 months
Decline, the most depressed, there is distending pain during chest, dilute when doing during stool, insomnia, examine its tongue arteries and veins, tongue is dark, and fat have greatly indentation, tongue
Bao Bai, stringy pulse.Through health examination Non Apparent Abnormality, according to its symptom and physical examination result, it is determined that for " fatigability subhealth state ", satisfy
Including in as object of study, give pharmaceutical composition of the present invention and intervene it, dosage is a ball on the one, Intervention periodicity
6 weeks.After intervening 4 weeks, patient's readme is tired, depressed, chest pain with distension sensation, stool time when doing the symptom such as dilute substantially alleviate.
Intervening after terminating, when doing when readme fatigue, inappetence, depressed, chest pain with distension sensation, stool, the symptom such as dilute disappears substantially.Stop
After medicine 6 weeks, following up a case by regular visits to it, readme has no the malaise symptoms such as tired.After drug withdrawal 12 weeks, again it is followed up a case by regular visits to,
When doing when readme fatigue, inappetence, chest pain with distension sensation, stool, the disease such as dilute does not occurs, its tired complete incidence graph.
Claims (10)
1. a ginseng pills of sea dog, it is characterised in that the weight portion meter of this each component of ginseng pills of sea dog:
Fur seal fine powder 30-40 part, Fructus Lycii 70-80 part, Radix Ginseng 70-80 part, Radix Codonopsis 50-60 part, Herba Epimedii 30--40 part, Fructus Vitis viniferae
Seed 30-40 part, Radix Astragali 30-40 part, Cortex Eucommiae 50-60 part, dietary fiber 10-20 part, Mel 20-30 part, Pulvis Talci 200-220
Part, Arabic tree powder 10-20 part.
Ginseng pills of sea dog the most according to claim 1, it is characterised in that this ginseng pills of sea dog also includes that invigorating the spleen and replenishing QI is combined
Thing, the weight portion of described QI invigorating compositions is 60-70.
Ginseng pills of sea dog the most according to claim 2, it is characterised in that the weight portion of each component of described invigorating middle warmer compositions
For: Rhizoma Atractylodis Macrocephalae 5-7 part, Poria 6-8 part, Pericarpium Citri Reticulatae 3-5 part, Radix Angelicae Sinensis part 6-8, Rhizoma Cimicifugae 5-6 part, Radix Bupleuri 8-10 part, Radix Glycyrrhizae Preparata 6-8 part,
Rhizoma Zingiberis Recens 3-4 part, Fructus Jujubae 5-8 part.
Ginseng pills of sea dog the most according to claim 1, it is characterised in that fur seal fine powder 35, Chinese holly in described ginseng pills of sea dog
Fructus Lycii 75, Radix Ginseng 75, Radix Codonopsis 55, Herba Epimedii 35, Semen Vitis viniferae 35, the Radix Astragali 35, the Cortex Eucommiae 55, dietary fiber 15, Mel 25, Pulvis Talci
210, Arabic tree powder 15.
Ginseng pills of sea dog the most according to claim 1, it is characterised in that the weight portion of this each component of ginseng pills of sea dog
Meter:
Fur seal fine powder 30, Fructus Lycii 80, Radix Ginseng 70, Radix Codonopsis 50, Herba Epimedii 30, Semen Vitis viniferae 40, the Radix Astragali 30, the Cortex Eucommiae 60, meals are fine
Dimension 20, Mel 28, Pulvis Talci 215, Arabic tree powder 18.
Ginseng pills of sea dog the most according to claim 2, it is characterised in that the weight portion of this each component of ginseng pills of sea dog
Meter:
Fur seal fine powder 40, Fructus Lycii 70, Radix Ginseng 80, Radix Codonopsis 60, Herba Epimedii 40, Semen Vitis viniferae 30, the Radix Astragali 40, the Cortex Eucommiae 50, meals are fine
Dimension 10, Mel 20, Pulvis Talci 200, Arabic tree powder 10.
Ginseng pills of sea dog the most according to claim 2, it is characterised in that the weight portion of this each component of ginseng pills of sea dog
Meter:
Fur seal fine powder 40 parts, Fructus Lycii 80 parts, Radix Ginseng 80 parts, Radix Codonopsis 60 parts, Herba Epimedii 38 parts, Semen Vitis viniferae 34 parts, the Radix Astragali 36 parts,
The Cortex Eucommiae 57 parts, dietary fiber 18 parts, Mel 26 parts, Pulvis Talci 205 parts, Arabic 11 parts of powder of tree, invigorating the spleen and replenishing QI compositions 75 parts.
8. the method for the ginseng pills of sea dog prepared as described in claim 1-7 any one, it is characterised in that the method
Specifically include following steps:
Step 1: by Herba Epimedii and Radix Ginseng, clean, clean, be dried, weigh the most by weight, obtain after purification processes respectively
Herba Epimedii total flavones and saponin extract, standby；
Step 2: Fructus Lycii, Radix Codonopsis, Semen Vitis viniferae, the Radix Astragali, Cortex Eucommiae crude drug are cleaned, clean, dry, pulverize into coarse powder, subsequently
Weigh by weight and add in extraction pot, adding the purified water of crude drug weight 10-11 times, being heated to boiling, decocting 3 little
Time, medicinal liquid is leached, obtains filtrate for the first time, standby；
Step 3: herb liquid extracts for the second time: in extraction pot, adds the purified water of crude drug weight 7-8 times, and is heated to
Boiling, decocts 1.5-1.8 hour, is leached by medicinal liquid, obtains second time filtrate, standby；
Step 4: herb liquid extracts for the third time: in extraction pot, adds the purified water of crude drug weight 4-6 times, is heated to boiling,
Decoct 1 hour, medicinal liquid is leached, obtain third time filtrate, standby；
Step 5: by first time standby for step 1 to 3, for the second time, for the third time filtrate be placed in container and be uniformly mixed, heavy
Form sediment, filter, obtain filtrate, standby；
Step 6: step 5 gained filtrate is concentrated with Chinese drug steaming device, is concentrated into 2/5ths of filtrate volume, obtains concentrated solution,
Standby；
Step 7: step 6 gained concentrated solution is added the ethanol of the content 95% of 1 times of weight, carries out precipitate with ethanol 72 hours, so
After by separation of ethanol, obtain for the first time fluid extract；The ethanol of the content 95% that first-class extractum is added 0.8 times of weight is carried out
Precipitate with ethanol 48 hours, is then peeled off ethanol, obtains second time fluid extract；Second time fluid extract is added the content of 0.7 times of weight
The ethanol of 95% carries out precipitate with ethanol 24 hours, the most again separation of ethanol, obtains fluid extract, standby；
Step 8: the most yellow by adding fur seal fine powder, Mel, ginsenoside Rg1 and Herba Epimedii in fluid extract standby for step 7 gained
Ketone, stirs；
Fluid extract sodium hydroxide adjustment pH value standby for step 8 gained to 4.8～5.5, is then existed by step 9
120 DEG C carry out high temperature sterilize 30 minutes, mix, according to the preparation technology system of pill with sucrose, Pulvis Talci, Arabic tree powder
For obtaining ginseng pills of sea dog.
Method the most according to claim 8, it is characterised in that the purifying technique of the Radix Ginseng in described step 1 is, specifically wraps
Include following steps:
Step 1: ginseng raw material is crushed to coarse powder, adds the alcohol solution dipping that volume fraction is 50～70%, solid-liquid
Ratio 1:10～1: 15kg/L, extraction takes 2～4 times, and each extraction time is 6～7min, after extracting solution stands
Filter, merging filtrate, through microwave decompression Distillation recovery ethanol, obtain Radix Ginseng total saponins crude product extractum；Add this extractum 5～
The water of 10 times of volumes, is heated to 70～80 DEG C, is incubated 1～3min, and filtrate removes liposoluble constituent therein with ether,
Extracting 2～3 times with water saturated butanol solution, microwave decompression distillation and concentration reclaims n-butyl alcohol, obtains Radix Ginseng total saponins again
Fine work extractum；
Step 2: Radix Ginseng total saponins fine work extractum is added the ethanol solution dilution that volume fraction is 10%, makes extractum quality and second
The ratio of alcoholic solution volume is 1:10～1:18kg/L, obtains diluent, and by macroporous adsorptive resins, eluent flow rate is
3mL/min, resolves with the ethanol solution that volume fraction is 40%, and ethanol volume used is the twice of diluent, obtains content big
In the protopanaxatriol ginsenoside eluent of 25%；Resolve with the ethanol solution that volume fraction is more than 80% again, ethanol used
Liquor capacity is the twice of diluent, obtains content panoxadiol's type saponin eluent more than 50%；
Step 3: in panoxadiol's type saponin eluent add acetic acid, make acetic acid volume fraction in eluent be 1%～
5%, it is 60～80 DEG C through temperature, the heating in water bath of time 1.5～2h, by macroporous adsorptive resins after reaction,
Wash acid ion with water and other is dissolved in the impurity of water, then with the ethanol solution parsing of volume fraction more than 80%, eluent
The ginsenoside extract containing Rg3 and Rh2 is obtained through microwave decompression distillation.
Technique the most according to claim 8, it is characterised in that the purifying technique of the Herba Epimedii in described step 1 is, tool
Body comprises the following steps:
Step 1. pretreatment: after being pulverized by dried Herba Epimedii, obtain Herba Epimedii coarse powder；
Step 2. is extracted: use ethanol reflux extraction to extract Herba Epimedii coarse powder, it is thus achieved that crude extract；
Step 3. purification: described crude extract is configured to suspension according to solid-to-liquid ratio 1:10-15 distilled water, and regulates suspendible
The pH value of liquid is 3.2～3.8；Use power be 80-100W microwave heating to 20-30 DEG C, then suspension is centrifuged,
Take supernatant, be splined on macroporous adsorptive resins with the loading flow velocity of 1.0～3.0BV/h；Stand after absorption,
Then carry out eluting by the elution speed of 1.0～3.0BV/h, after being first washed till without muddiness with distilled water, then with 3～
5BV concentration is 40%～50% ethanol elution, collects 0.5～2.0BV interval eluent, is returned by described eluent
Receive ethanol, obtain extractum, by extractum in 40～60 DEG C of drying under reduced pressure to dry, obtain Herba Epimedii total flavones.
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