CN106074666A - A kind of pharmaceutical composition for treating asthma - Google Patents

A kind of pharmaceutical composition for treating asthma Download PDF

Info

Publication number
CN106074666A
CN106074666A CN201610573985.6A CN201610573985A CN106074666A CN 106074666 A CN106074666 A CN 106074666A CN 201610573985 A CN201610573985 A CN 201610573985A CN 106074666 A CN106074666 A CN 106074666A
Authority
CN
China
Prior art keywords
pharmaceutical composition
radix rhodiolae
weikangling
water solution
treating asthma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201610573985.6A
Other languages
Chinese (zh)
Other versions
CN106074666B (en
Inventor
于孟飞
马月娥
刘庆华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
South Central Minzu University
Original Assignee
South Central University for Nationalities
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by South Central University for Nationalities filed Critical South Central University for Nationalities
Priority to CN201610573985.6A priority Critical patent/CN106074666B/en
Publication of CN106074666A publication Critical patent/CN106074666A/en
Application granted granted Critical
Publication of CN106074666B publication Critical patent/CN106074666B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a kind of pharmaceutical composition for treating asthma, containing active component Radix Rhodiolae water solution extract and WEIKANGLING.Wherein Radix Rhodiolae water solution extract accounts for 45% the 95% of composition total weight, and WEIKANGLING accounts for 5% the 55% of composition total weight.The research of related experiment shows, the pharmaceutical composition of the present invention can reach to treat the purpose of asthma by the tracheal smooth muscle that expansion is shunk, and pharmaceutical composition use in conjunction Radix Rhodiolae water solution extract and WEIKANGLING, curative effect is obvious, the property of medicine stablizes safety, has good producing feasibility and application prospect.

Description

A kind of pharmaceutical composition for treating asthma
Technical field
The present invention relates to a kind of medicine for treating asthma, especially relate to one and make with Radix Rhodiolae and WEIKANGLING For the pharmaceutical composition of effective ingredient, belong to biomedicine field.
Background technology
In recent years with the decline of environmental quality, various airway reactivity diseases, as atypism asthma, bronchial asthma, Chronic coughs etc. become the common disease of respiratory system, and sickness rate is in ascendant trend year by year.If there is serious acute in asthmatic patient Outbreak, may be fatal when giving treatment to not in time.Asthmatic patient can cause activity, limitation of movement, makes quality of life decline, and bring through Burden in Ji, the even life to household negatively affect.Moreover, asthma harm is also reflected in asthma and can cause slowly The complication such as property obstructive pulmonary disease (COPD), emphysema, pulmonary heart disease, heart failure, respiratory failure.Therefore, research and development safety, The medicine of effective treatment asthma becomes the urgent needs of society.
Radix Rhodiolae enjoys the good reputation of " plateau Radix Ginseng ", possesses the pharmacological actions such as anti-hypoxia, resisting fatigue, slow down aging, generally For every field such as medical treatment, health product.The kind of Rhodida plant is much, the existing domestic and international chemistry to Rhodida plant The kind that composition had been studied has: Radix Rhodiolae, Radix Rhodiolae, Rhodiola rosea L., Rhodiola Crassulaceae etc..Wherein, greatly Premium Herba hylotelephii erythrosticti is referred to as the superfine product in Radix Rhodiolae, the butyl alcohol that contains, rhodioside, cinnamyl alcohol, Quercetin, tricin-7-O- β-D-Glucose glycosides and Chrysophanol8-O-β-D-glucopyranoside, anthocyanin, the content of Radix Rhodiolae glycosides isoreactivity material are them 5-10 times of his kind Radix Rhodiolae.Therefore, Radix Rhodiolae relative to the Radix Rhodiolae of other kinds as preparing drug regimen On the raw material of thing, there is significant advantage.
WEIKANGLING is as the medicine for enterogastritis of traditional sense, and everyone knows about it for the curative effect in terms of the intestines and stomach treatment.The component of WEIKANGLING Including the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Radix Glycyrrhizae, Poria, Rhizoma Corydalis, sea Piao sheath etc..Wherein the Radix Paeoniae Alba has the merit of suppressing the hyperactive liver emergency, relieving spasm to stop pain Effect；In Radix Glycyrrhizae, the chemical composition such as triterpenoid saponin has the effect of calmness, analgesia, antiinflammatory, smooth muscle relaxing；The Radix Paeoniae Alba is combined with Radix Glycyrrhizae There is relieving spasm to stop pain, the drug effect of YIN and YANG balance regulating；Rhizoma Corydalis (processed with vinegar), Endoconcha Sepiae possess the effect of antacid；Poria energy enhancing human body immunity Function, and pachyman can reduce gastric secretion and free acid content.All medicine property of medicine is gentle, collect ascending, descending, clear and, disappear in Integrally, in acute and chronic gastritis, duodenal ulcer has significant curative effect.
At present, there is not yet the report that WEIKANGLING is used for preparing treatment asthmatic medicament as the medicine of active substance, more Do not met and Radix Rhodiolae and WEIKANGLING were combined the relevant report preparing treatment asthmatic medicament compositions.
Summary of the invention
The present invention provides a kind of pharmaceutical composition for treating asthma, carries containing active component Radix Rhodiolae aqueous solution Take thing and WEIKANGLING.The pharmaceutical composition of the present invention can reach to treat the mesh of asthma by the tracheal smooth muscle that expansion is shunk , and pharmaceutical composition use in conjunction Radix Rhodiolae water solution extract and WEIKANGLING, curative effect is obvious, the property of medicine is stably pacified Entirely, there is good producing feasibility and application prospect.
The purpose of the present invention is achieved through the following technical solutions:
A kind of pharmaceutical composition for treating asthma, described pharmaceutical composition is by Radix Rhodiolae and the group of WEIKANGLING Become.Wherein, described Radix Rhodiolae is Radix Rhodiolae water solution extract.
Further improvement of the present invention, Radix Rhodiolae aqueous solution in described a kind of pharmaceutical composition for treat asthma The weight of extract accounts for the 45%-95% of gross weight, and WEIKANGLING weight accounts for the 5%-55% of gross weight.
Further improvement of the present invention, Radix Rhodiolae water solution extract obtains as follows: the quality such as take Fresh Radix Rhodiolae flower petal and distilled water are put in pharmacy container, soak 30min, then use slow fire boiling 4h, filter, Medicinal liquid, then spend the distilled water of the quality such as petal with fresh Radix Rhodiolae toward addition in the petal slag filtered, then use slow fire Decoct 4h, filter, obtain secondary medicinal liquid；Medicinal liquid and secondary medicinal liquid uniformly being mixed, freeze with subzero 20 DEG C of dry ice, vacuum is done Dry machine evacuation lyophilizing.
The beneficial effects of the present invention is:
1, the present invention is used for treating the medicine of asthma by Radix Rhodiolae water solution extract and WEIKANGLING combination preparation Compositions.Showing through research, Radix Rhodiolae water solution extract and WEIKANGLING are relaxed for tracheal smooth muscle each other There is synergism, at short notice can diastole rapidly, and the efficiency of diastole is higher than one-component, prepared by this compositions Pharmaceutical composition the treatment of asthma is had more significant curative effect；
2, the invention provides Radix Rhodiolae and the WEIKANGLING new application on treatment asthmatic medicament；And the present invention selects With the medicine that WEIKANGLING and the Radix Rhodiolae both property of medicine are gentle, two kinds of medicines are used in combination property of medicine compatibility and for treatment heavy breathing Breathe heavily and have more preferable curative effect, the safety of medication can be ensured while improving treatment asthma curative effect.
Detailed description of the invention
The present invention, for preparing the WEIKANGLING for the treatment of asthmatic medicament, can be WEIKANGLING granule or stomach-recovering capsule, stomach health Spirit granule or the prescription of stomach-recovering capsule and preparation method etc. see " Chinese Pharmacopoeia " (2015 editions) page 1179 to page 1180.
Below in conjunction with specific embodiment, the present invention is further described, but protection scope of the present invention is not limited to that:
One, embodiment
Respectively according to component and the proportioning of table 1, embodiment 1-6 of the pharmaceutical composition of the preparation present invention, and comparative example 1 With 2:
Table 1 embodiment and the component of comparative example and proportioning
Embodiment of the present invention 1-6, the Radix Rhodiolae water solution extract of comparative example 1, obtain: take as follows The fresh Radix Rhodiolae flower petal of quality and distilled water are put in pharmacy container, soak 30min, then use slow fire boiling 4h, Filter, obtain a medicinal liquid, then the distilled water toward quality such as addition in the petal slag filtered and fresh Radix Rhodiolae flower petals, then Use slow fire boiling 4h, filter, obtain secondary medicinal liquid；Medicinal liquid and secondary medicinal liquid are uniformly mixed, freeze with subzero 20 DEG C of dry ice, Vacuum drier evacuation lyophilizing, obtains Radix Rhodiolae water solution extract.
Take Radix Rhodiolae water solution extract and WEIKANGLING granule according to the proportioning of table 1, uniformly obtain this after mixing The pharmaceutical composition of bright embodiment 1-6.
Two, experimental example
1 preparation experiment reagent
1.1 preparations high calcium solution (PSS)
Take 135mmol NaCl, 5mmol KCl, 2mmol CaCl2, 10mmol glucose, 10mmol 4-hydroxyethyl piperazine Ethyl sulfonic acid, 1mmol MgCl2·6H2O is dissolved in 800mL sterilized water, regulates pH value of solution to 7.40 with the NaOH of 0.5mol/L, fixed Hold to 1000mL.
1.2 preparation acetylcholine (Ach) solution
Take 8.15mg acetylcholine and be dissolved in the high calcium solution of 500mL, prepare the acetylcholine solution of 100 μm ol/L.
1.3 compounding pharmaceutical solution
Take the pharmaceutical composition of 0.3g embodiment 1-6, dissolve with 3mL high calcium solution, regulate pH to 7.40, prepare embodiment The high calcium solution of pharmaceutical composition.
Take the medicine of 0.3g comparative example 1 and 2, dissolve with the high calcium solution of 3mL, regulate pH to 7.40, prepare comparative example medicine The high calcium solution of thing.
The preparation of 2 tracheas
First use cervical dislocation to put to death mice, afterwards mice is placed on dissection plate epigastrium and upwards fixes, spray 75% Ethanol, in abdominal part, is mentioned skin of abdomen with tweezers, more first abdominal part is cut off with sterilized shears, separated by fur, then Shears being cut off (scissors bit deviation trachea position, in case breaking) along thoracic cavity to cervical region, after exposing trachea, first cutting off Adam's apple Place, then Adam's apple (not pullling) is gently carried with tweezers, shears slightly tilts to cut off the connective tissue of trachea the right and left, is finally separating and gives vent to anger Pipe and cardiopulmonary tissue, and to be placed on rapidly in the PSS solution of pre-cooling, and the mice dissected puts that corpse is special deposits ice into Case.
By the in vitro tissue of taking-up by esophagus upper, trachea under mode be positioned on dissecting pan (in dissecting pan in advance It is placed with the PSS solution of pre-cooling), upper end fixes Adam's apple, each selects a piece of lobe of the lung to be fixed and (preferably select about lower end Select the lobe of the lung on the lower).After fixing, dissecting pan is placed under inverted microscope, first cuts off esophagus, then with Venus's shears Cut off the tissue that trachea both sides are unnecessary.In microscope it can be seen that the most clearly trachea sample time, take about 5mm length trachea (Delta Region near trachea should be taken, because this segment smoothing myocyte is more, useful to experiment) as far as possible.Trachea is handled well After, it is possible to Mouse trachea is first hung up properly with hook, then is connected with tonotransducer carefully by hook, finally place In the 6mLPSS containing 37 DEG C preheatings and the constant temperature water bath that can uninterruptedly lead to oxygen.
Give the basic load of tracheal smooth muscle (ASM) 300mg, within every 15 minutes, change a PSS solution, continuous four Secondary.After balancing 60 minutes, carry out pre-stimulation 1 time by 100 μm ol/LAch, with the PSS eluting 1 of 37 DEG C of waters bath with thermostatic control after 15 minutes Secondary, then it is spaced 5 minutes eluting once, totally three times.Eluting stimulates by 100 μm ol/LAch after terminating, and waits that curve rises to High point and slope are about zero, make trachea be in optimal retraction state, simulate asthmatic patient smooth muscle model, start dosing examination Test.
The 3 detection medicine diastole effects to tracheal smooth muscle
First with Ach, isolated tracheal smooth muscle is carried out preshrinking process, when reaching stable state, in bath, add 50 μ L respectively The high calcium solution of comparative example 1,2 medicine, the high calcium solution of embodiment 1-6 pharmaceutical composition, detect trachea tension variation.
For the diastole effect to mice tracheal smooth muscle of the drugs compared solution, then two control experiments are set: one is empty White matched group, does not i.e. make any process to mice tracheal smooth muscle；Two is acetylcholine (Ach) group, the most only adds Ach stimulation Tracheal smooth muscle shrinks.
Experimental result sees table 2.
The different experiments group experimental result such as table 2 below to rat trachea hypotensive activity:
The table 2 different experiments group experimental result to rat trachea hypotensive activity
In table, 1, mice trachea tension force (mN) be the tracheal smooth muscle pulling force of unit weight；
2, diastolic rate=(before adding medicine, mice trachea tension force adds mice trachea tension force after medicine)/(addition acetyl Mice trachea tension force before mice trachea tension force adds acetylcholine after choline) × 100%, wherein, add mice gas after medicine Pipe tension force is the mice trachea tension force after adding diastole medicine 10min.
It is concluded that by table 2
(1) data of blank group represent and are left intact trachea, and the tension stability of trachea is at 4.1mN；Acetylcholine Group expression acetylcholine stimulates isolated tracheal smooth muscle to shrink, and isolated tracheal smooth muscle tension force changes to 12.3mN from 4.1mN, And under conditions of without diastole medicine, the tension force of tracheal smooth muscle can maintain 60 minutes.
(2) after adding medicine, in vitro ASM tension force begins to decline from 12.3mN, and after 10min, mice trachea tension force keeps steady It is fixed, the more each group of mice trachea diastole effect stimulating Ach is strong and weak.Individually use the Radix Rhodiolae in comparative example 1 or 2 Water solution extract has or WEIKANGLING is for diastole bronchus smooth muscle, and diastolic rate is respectively 65.8% and 53.7%.Embodiment 1-6 Pharmaceutical composition, for the diastolic rate of diastole bronchus smooth muscle minimum 81.7%, be 92.7% to the maximum.Analyze experimental data Can obtain, the inhibitory action that the pharmaceutical composition tracheal smooth muscle to being caused by Ach shrinks is substantially better than the folk prescription of same dose, this One result further illustrates WEIKANGLING and Radix Rhodiolae water solution extract share and can work in coordination with diastole bronchus smooth muscle.
(3) can show by embodiment 1-6 that tracheal smooth muscle diastole effect is affected by the pharmaceutical composition of different ratio.Point Analysis shows, in embodiment 4, Radix Rhodiolae water solution extract accounts for pharmaceutical composition 75%, WEIKANGLING accounts for pharmaceutical composition 25% Time, pharmaceutical composition is the most notable to the diastole effect of tracheal smooth muscle, reaches 92.7%.Therefore, this pharmaceutical composition is most preferably joined Ratio accounts for compositions 75% for Radix Rhodiolae water solution extract, WEIKANGLING accounts for the 25% of extractive composition.
Content disclosed in this invention, can meet the application of those skilled in the art, meanwhile, read the upper of the present invention After stating content, the present invention can be made various change or amendment by those skilled in the art, these behaviour based on the present invention Fall within limited range of the present invention equally.

Claims (4)

1. the pharmaceutical composition being used for treating asthma, it is characterised in that: described pharmaceutical composition is by Radix Rhodiolae stomach function regulating Kang Ling forms.
A kind of pharmaceutical composition for treating asthma the most according to claim 1, it is characterised in that: described big premium scape It is Radix Rhodiolae water solution extract.
A kind of pharmaceutical composition for treating asthma the most according to claim 2, it is characterised in that: described drug regimen In thing, the weight of Radix Rhodiolae water solution extract accounts for the 45%-95% of gross weight, and WEIKANGLING weight accounts for the 5%-of gross weight 55%.
A kind of pharmaceutical composition for treating asthma the most according to claim 2, it is characterised in that: Radix Rhodiolae water Solution extract obtains as follows: pharmacy container put into by the fresh Radix Rhodiolae flower petal and the distilled water that the quality such as take In, soak 30min, then use slow fire boiling 4h, filter, obtain a medicinal liquid, then toward addition in the petal slag filtered and fresh greatly The distilled water of the quality such as premium Herba hylotelephii erythrosticti flower petal, then use slow fire boiling 4h, filter, obtain secondary medicinal liquid；By a medicinal liquid and secondary Medicinal liquid uniformly mixes, and freezes with subzero 20 DEG C of dry ice, vacuum drier evacuation lyophilizing.
CN201610573985.6A 2016-07-19 2016-07-19 A kind of pharmaceutical composition for being used to treat asthma Expired - Fee Related CN106074666B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610573985.6A CN106074666B (en) 2016-07-19 2016-07-19 A kind of pharmaceutical composition for being used to treat asthma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610573985.6A CN106074666B (en) 2016-07-19 2016-07-19 A kind of pharmaceutical composition for being used to treat asthma

Publications (2)

Publication Number Publication Date
CN106074666A true CN106074666A (en) 2016-11-09
CN106074666B CN106074666B (en) 2018-01-30

Family

ID=57221157

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610573985.6A Expired - Fee Related CN106074666B (en) 2016-07-19 2016-07-19 A kind of pharmaceutical composition for being used to treat asthma

Country Status (1)

Country Link
CN (1) CN106074666B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102349973A (en) * 2007-06-07 2012-02-15 杨文龙 Preparation method of traditional Chinese medicinal capsule
CN105749048A (en) * 2016-05-03 2016-07-13 薛景森 Traditional Chinese medicine for treating allergic asthma

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102349973A (en) * 2007-06-07 2012-02-15 杨文龙 Preparation method of traditional Chinese medicinal capsule
CN105749048A (en) * 2016-05-03 2016-07-13 薛景森 Traditional Chinese medicine for treating allergic asthma

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
吴清: "《230种中药颗粒剂和胶囊剂制备关键技术》", 31 May 2008 *
国家药典委员会: "《中国药典2015版一部》", 1 January 2015, 化学工业出版社 *
李红颖: "胃康灵胶囊质量检验标准的研究", 《哈尔滨医药》 *
马国刚: "《野生食用植物资源与健康营养》", 31 May 2011 *

Also Published As

Publication number Publication date
CN106074666B (en) 2018-01-30

Similar Documents

Publication Publication Date Title
CN107412331A (en) Nasal formulations for treating rhinitis and its preparation method and application
CN105663000A (en) Rhizome bletillae moisturizing gel product and preparation method thereof
CN106109511B (en) A kind of ginkgo biloba p.e and its preparation method and application
CN111991543A (en) Traditional Chinese medicine composition for severe adjuvant therapy of new coronary pneumonia and preparation method thereof
CN101822729B (en) Medicine for treating slow arrhythmia sick sinus syndromes
CN104055909A (en) Application of compound donkey-hide gelatin pulp in preparation of medicament for menstrual period health care
CN106039020B (en) Stomach Kang Ling is preparing the application in treating asthmatic medicament
CN104257762B (en) A kind of pharmaceutical composition and prevention thereof and the osteoporotic purposes for the treatment of
CN106074666A (en) A kind of pharmaceutical composition for treating asthma
CN109288904A (en) The Chinese medicine composition and its preparation method and application of prevention or treatment arrhythmia cordis
CN102198192B (en) Traditional Chinese medicine composition for treating HINI and application thereof
CN108096318A (en) Treat pharmaceutical composition of cardiovascular and cerebrovascular disease and its preparation method and application
CN104740581B (en) A kind of application of cold asthma patch of fragrant fiber crops and its detection method
CN1660345A (en) Prepared Chinese medicine for treating burn and scald
CN109793826A (en) A kind of Chinese medicine composition for treating fracture of children
CN108524746A (en) A kind of Chinese medicine composition of prevention fowl cough
CN104415088B (en) A kind of pharmaceutical composition for treating liver fibrosis and its preparation method and application
CN106511394A (en) Novel application of fatty oil extract of aspongopus
CN106074643A (en) Cortex Acanthopanacis Giraldii leaf and extract purposes in the medicine or health food of preparation resisting fatigue thereof
CN105687499A (en) Betaxolol containing pharmaceutical composition for treating hypertension and preparation method thereof
CN106176857A (en) A kind of blood ruton capsules Chinese medicine composition and preparation method thereof
CN105920443A (en) Medicament for treating bronchial asthma or emphysema and preparation method thereof
CN105853740A (en) Anesthetic for stomachoscopy
CN106109427A (en) The application in preparation treatment asthmatic medicament of a kind of compound recipe puppet fiber crops U.S. sweet smell sheet
CN105640792B (en) Dihydromyricetin is in beauty except the application in spot product

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180130

Termination date: 20200719

CF01 Termination of patent right due to non-payment of annual fee