CN106063973A - A kind of pacing circuitry negative pressure clamp device being applied to cardiac pacemaker - Google Patents
A kind of pacing circuitry negative pressure clamp device being applied to cardiac pacemaker Download PDFInfo
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- CN106063973A CN106063973A CN201610348891.9A CN201610348891A CN106063973A CN 106063973 A CN106063973 A CN 106063973A CN 201610348891 A CN201610348891 A CN 201610348891A CN 106063973 A CN106063973 A CN 106063973A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/378—Electrical supply
Abstract
The invention discloses a kind of pacing circuitry negative pressure clamp device being applied to cardiac pacemaker, described device includes: pacing circuitry and DAC module；Described pacing circuitry is connected with DAC module；Described pacing circuitry includes: metal-oxide-semiconductor, diode, resistance and electric capacity；Described resistance shields, including the first resistance, the second resistance and the 3rd resistance；Described electric capacity utilize its charge-discharge characteristic to produce pacemaker impulse, including the first electric capacity and the second electric capacity；Described metal-oxide-semiconductor is used as switch, including the first to the 9th metal-oxide-semiconductor；Described diode utilizes its clamping performance to reduce the value of electric capacity negative voltage；Described DAC module is for regulating the amplitude of pacing circuitry pacemaker impulse.Device proposed by the invention utilizes diode clamp to prevent negative pressure from producing, or reduces the value of negative voltage, it is to avoid PN junction forward conduction, has ensured the correctness of pacing circuitry function.This circuit structure is simple, low in energy consumption, easy of integration.
Description
Technical field
The invention belongs to integrated circuit fields, be specifically related to a kind of pacing circuitry negative pressure clamper being applied to cardiac pacemaker
Device.
Background technology
At present, in, state-owned thousand of ten thousand bradycardias, arrhythmia, the patient of conduction block maintain heart beating by cardiac pacemaker
Maintain life.Implanted cardiac pacemaker moment monitoring heart beating, it may be necessary to sent by the pacing electrode contacted with cardiac muscle
Stimulation pulse signal, to ensure that heart is beated by normal rhythm.If pacing circuitry breaks down in pacemaker, it is impossible to by estimating
Amplitude of fighting granting stimulates or exports without pacemaker impulse, then patient can be caused fatal harm.Secondly, Implanted cardiac pacemaker
Needing to work more than 10 years continuously in human body, this just requires that cardiac pacemaker is the most necessary in the system-level design with circuit-level
Follow strictly low-power consumption principle.Pacing circuitry in cardiac pacemaker is the module of power consumption, and pacemaker impulse is i.e. to rise
The DC energy of device battery of fighting is converted to electric pulse output, and this energy conversion efficiency is the biggest on the impact of pacemaker overall power.
Again, the small form factor requirements of Implanted cardiac pacemaker functional circuit therein and element are integrated in chip internal as much as possible.
At present, main flow is become based on Si CMOS technology design cardiac pacemaker special IC.But, in pacing circuitry in order to
Produce high voltage stimulus pulse signal, there is the different voltage domains such as high-low pressure and the charge and discharge process of bulky capacitor, thus produce
Negative pressure and the problem such as PN junction positively biased pacemaker impulse can be caused to provide fault, reduce power consumption efficiency simultaneously.This is for cardiac pacing
Device is it is critical that problem.
Summary of the invention
Based on this, the invention discloses a kind of pacing circuitry negative pressure clamp device being applied to cardiac pacemaker；
Described device includes: pacing circuitry and DAC module；
Described pacing circuitry is connected with DAC module；
Described pacing circuitry includes: metal-oxide-semiconductor, diode, resistance and electric capacity；
Described resistance shields；
Described electric capacity utilizes its charge-discharge characteristic to produce pacemaker impulse；
Described metal-oxide-semiconductor is used as switch；
Described diode utilizes its clamping performance to reduce the value of electric capacity negative voltage.
Device proposed by the invention utilizes diode clamp to prevent negative pressure from producing, or reduces the value of negative voltage, it is to avoid PN
Knot forward conduction, has ensured the correctness of pacing circuitry function.This circuit structure is simple, low in energy consumption, easy of integration.
Accompanying drawing explanation
Fig. 1 is the pacing circuitry schematic diagram in one embodiment of the invention with diode negative pressure clamp device；
Fig. 2 is pacing circuitry electric capacity about the C1 pole plate not having diode negative pressure clamp device in one embodiment of the invention
Voltage simulation result figure；
Fig. 3 is pacing circuitry electric capacity about the C1 pole plate in one embodiment of the invention with diode negative pressure clamp device
Voltage simulation result figure.
Detailed description of the invention
Below in conjunction with the accompanying drawings, by concrete example, the invention will be further described, but does not constitute the limit to the present invention
System.
In one embodiment, the present invention is a kind of pacing circuitry negative pressure clamp device being applied to cardiac pacemaker, institute
State device to include: pacing circuitry and DAC module；
Described pacing circuitry is connected with DAC module；
Described pacing circuitry includes: metal-oxide-semiconductor, diode, resistance and electric capacity；
Described resistance shields；
Described electric capacity utilizes its charge-discharge characteristic to produce pacemaker impulse；
Described metal-oxide-semiconductor is used as switch；
Described diode utilizes its clamping performance to reduce the value of electric capacity negative voltage.
More excellent, with specific reference to the pacing circuitry diode negative pressure clamper being applied to cardiac pacemaker in Fig. 1, this example
Device includes altogether 9 metal-oxide-semiconductors, 3 resistance, 2 electric capacity, 1 diode.Notice that the scope that the present invention is protected is not limited to
Example described herein.In this example, the metal-oxide-semiconductor that transistor all uses, triode transistor can be used to replace MOS simultaneously
Pipe.In this case, replace metal-oxide-semiconductor grid with transistor base, replace metal-oxide-semiconductor drain electrode with transistor collector, use three poles
Pipe emitter stage replaces metal-oxide-semiconductor source electrode.
The present embodiment proposes the pacing circuitry diode negative pressure clamp device being applied to cardiac pacemaker, this circuit structure
Simply, low in energy consumption, make use of the clamper function of diode, reduce the right pole plate of electric capacity and drawn negative magnitude of voltage, it is therefore prevented that be follow-up
In polar selecting switch circuit, the forward conduction of metal-oxide-semiconductor PN junction, improves and recharges speed, reduces and expects pace-making arteries and veins
Error between punching, has ensured the correctness of circuit function.
In one embodiment, described resistance includes the first resistance, the second resistance and the 3rd resistance；
Described electric capacity includes the first electric capacity and the second electric capacity；
Described metal-oxide-semiconductor includes the first to the 9th metal-oxide-semiconductor.
In one embodiment, in described pacing circuitry, one end of the first resistance is connected with the outfan of DAC module, the
The other end of one resistance and the drain terminal of the first metal-oxide-semiconductor are connected；
One end of described second resistance respectively with the source of the first metal-oxide-semiconductor, the second metal-oxide-semiconductor drain terminal is connected with heart negative electrode
Connecing, the other end of the second resistance and the second metal-oxide-semiconductor source are connected and ground connection；
Described 3rd resistance one end is connected with the 8th metal-oxide-semiconductor source, the other end respectively with the 7th metal-oxide-semiconductor source and the 9th
Metal-oxide-semiconductor drain terminal is connected and connects supply voltage；
One end of described first electric capacity is connected with heart anode or pacemaker shell end, the other end and the leakage of the 3rd metal-oxide-semiconductor
End is connected with the 4th metal-oxide-semiconductor drain terminal；
One end of described second electric capacity is connected with the 5th metal-oxide-semiconductor source and the 8th metal-oxide-semiconductor drain terminal, the other end and the 6th
Metal-oxide-semiconductor drain terminal and the 9th metal-oxide-semiconductor source are connected；
Described diode and the first electric capacity are in parallel.
In the present embodiment, more specifically pacing circuitry is as it is shown in figure 1, include: right-hand member is connected on DAC outfan, left end
The first resistance being connected with the drain terminal of the first metal-oxide-semiconductor；On terminate at the source of the first metal-oxide-semiconductor, the second metal-oxide-semiconductor drain terminal and heart
Negative electrode, lower end is connected to the ground the second resistance connect；Left end is connected on supply voltage, and the source of right-hand member and the 8th metal-oxide-semiconductor is connected
3rd resistance；Right pole plate is connected with heart anode or pacemaker shell end, left pole plate and the 3rd metal-oxide-semiconductor drain terminal and the 4th MOS
The first electric capacity that pipe drain terminal is connected；Top crown is connected with the 5th metal-oxide-semiconductor source and the 8th metal-oxide-semiconductor drain terminal, bottom crown and
The second electric capacity that six metal-oxide-semiconductor drain terminals and the 9th metal-oxide-semiconductor source are connected；Drain terminal and the first resistance left end are connected, grid end and S1
Control signal is connected, source and the second metal-oxide-semiconductor drain terminal, the first metal-oxide-semiconductor that the second resistance upper end is connected with heart negative electrode；Leakage
End with the first metal-oxide-semiconductor source, the second resistance upper end is connected with heart negative electrode, and grid end is connected with S2 control signal, source and
The second metal-oxide-semiconductor that ground is connected；Drain terminal and the 4th metal-oxide-semiconductor drain terminal, the first left pole plate of electric capacity and the first diode anode be connected,
Grid end is connected with S3 control signal, and source is connected to the ground the 3rd metal-oxide-semiconductor connect；Drain terminal and the 3rd metal-oxide-semiconductor drain terminal, the first electric capacity
Left pole plate and the first diode anode are connected, and grid end is connected with S4 control signal, source and the 5th metal-oxide-semiconductor drain terminal and the 7th
The 4th metal-oxide-semiconductor that metal-oxide-semiconductor drain terminal is connected；Drain terminal is connected with the 4th metal-oxide-semiconductor source and the 7th metal-oxide-semiconductor drain terminal, grid end and S5
Control signal is connected, the 5th metal-oxide-semiconductor that source is connected with the 8th metal-oxide-semiconductor drain terminal and the second electric capacity top crown；Drain terminal and
Nine metal-oxide-semiconductor sources are connected with the second electric capacity bottom crown, and grid end is connected with S6 control signal, and source is connected to the ground the 6th connect
Metal-oxide-semiconductor；Drain terminal is connected with the 4th metal-oxide-semiconductor source and the 5th metal-oxide-semiconductor drain terminal, and grid end is connected with S7 control signal, source with
The 7th metal-oxide-semiconductor that supply voltage is connected；Drain terminal is connected with the 5th metal-oxide-semiconductor source and the second electric capacity top crown, grid end and S8
Control signal is connected, the 8th metal-oxide-semiconductor that source is connected with the 3rd resistance right-hand member；Drain terminal is left with supply voltage and the 3rd resistance
End is connected, and grid end is connected with S9 control signal, source be connected with the 6th metal-oxide-semiconductor drain terminal and the second electric capacity bottom crown
Nine metal-oxide-semiconductors；Anode and the 3rd metal-oxide-semiconductor drain terminal, the 4th metal-oxide-semiconductor drain terminal, the first left pole plate of electric capacity is connected, negative terminal and the first electric capacity
The first diode that right pole plate is connected with heart anode or pacemaker shell.In this circuit, resistance shields, and utilizes electricity
The charge-discharge characteristic held produces pacemaker impulse, and metal-oxide-semiconductor used is all made to switch purposes, utilizes diode clamp characteristic to reduce electric capacity
The value of C1 right-hand member negative voltage.
In one embodiment, the conduction voltage drop of described diode is less than 400mV.
In the present embodiment, in principle, diode forward conduction voltage drop is the least, and the first electric capacity right-hand member voltage can be made to occur
Negative value is the least；The lower limit of this forward conduction voltage drop is more than 0V in theory, and in reality, N is difficult to accomplish
Below 0.2V；PN junction forward conduction voltage is made to be about 0.7V in silicon materials, therefore, for avoiding MOS in rear class institute connection circuit
The parasitic PN junction positively biased of pipe or cause bigger electric leakage, according to measured result, N should be less than 0.4V, guarantee
Normal circuit operation.Therefore, the upper limit of 400mV is to be sayed for realizing this circuit on silica-based.
In one embodiment, described DAC module includes 5 input digit order numbers, it is possible to produce from 0 to VDD and step-length is
Configurable charging voltage V of 0.1VDAC, it is achieved the regulation to pacemaker impulse amplitude.
In the present embodiment, 5 input digit order numbers of DAC module can produce 32 digital codes, and described pacing circuitry needs
28 digital codes are used for controlling to produce configurable charging voltage V that step interval is 0.1V from 0V to 2.8VDAC, it is achieved to rising
Fight being fine-tuned of pulse amplitude.
In one embodiment, described charging voltage VDACTo the first electric capacity charging, within being used for producing one times of supply voltage
Pacemaker impulse.
In the present embodiment, for the pacemaker impulse within one times of supply voltage of generation, in the charging stage, metal-oxide-semiconductor M1, M3
Grid termination high level, charges to electric capacity C1；At discharge regime, metal-oxide-semiconductor M2, M3 grid termination high level, electric capacity C1 discharges.
In one embodiment, described charging voltage VDACTo the first electric capacity charging, another termination electricity of the first electric capacity during electric discharge
Source voltage, is used for producing the supply voltage pacemaker impulse to two times of supply voltages.
Circuit as shown in Figure 1, in the present embodiment, produces supply voltage concrete to the pacemaker impulse of two times of supply voltages
For: in the charging stage, electric capacity C1 is charged；At discharge regime, the termination high level conducting of metal-oxide-semiconductor M2, M4, M7 grid, electric capacity C1 is former
The reconfiguration supply voltage electric discharge of ground connection one end.
In one embodiment, described charging voltage VDACTo the first electric capacity charging, the second electric capacity is filled by supply voltage simultaneously
Electricity, the first electric capacity and the second capacitances in series during electric discharge, when the electric capacity of supply voltage charging discharges, another termination supply voltage, is used for
Produce two times of supply voltage to three times supply voltage pacemaker impulses.
Circuit as shown in Figure 1, in the present embodiment, is producing two times of supply voltage to three times supply voltage pacemaker impulses
Time, first pacemaker anode or pacemaker shell end are connected to the right pole plate of electric capacity C1, pacemaker negative electrode is connected to metal-oxide-semiconductor
M1 source, heart accesses this circuit through correct polarity path；Metal-oxide-semiconductor M1, M3, M6, M8 grid termination high level, remaining metal-oxide-semiconductor
Grid end all connects low level, makes electric capacity C1, C2 charge, and has gone up slowly through the upper voltage of 20ms, C1, owing to resistance R2 (rises
Certain protective role) it is far longer than R1 and metal-oxide-semiconductor M1 conducting resistance sum, so level V is about arrived in last charging on C1DAC, electric capacity
C2 top crown voltage is about VDD；All metal-oxide-semiconductor grid ends all connect low level, wait about 1ms；Metal-oxide-semiconductor M2, M4, M5, M9 grid terminate
High level, remaining metal-oxide-semiconductor grid termination low level, electric capacity C2 former ground connection one end reconfiguration supply voltage, electric capacity C1, C2 discharged in series,
It is equivalent to zero input response.Thus obtain two times of supply voltages pacemaker impulse to three times of supply voltage hearts.
When providing three multiplication of voltage pacemaker impulses, without diode D1, the electric capacity C1 right-hand member velocity of discharge is more than left end, makes
Electric capacity C1 right-hand member voltage at the end of electric discharge is become to be less than left end voltage.On entering during once charging process, metal-oxide-semiconductor M4 turns off,
Metal-oxide-semiconductor M3 turns on, and the left end of electric capacity C1 is moved to ground by metal-oxide-semiconductor M3, thus has negative voltage at electric capacity C1 right-hand member and produce, and causes it
Connected metal-oxide-semiconductor PN junction positively biased, causes pacing voltage and is unable to reach desired value, thus cause circuit normally to work.
In one embodiment, when the first electric capacity two ends pressure drop is higher than diode turn-on voltage, diode current flow, first
Electric capacity both end voltage difference is clamped in N.
The present embodiment utilizes the voltage clamp characteristic of the Schottky diode D1 with less forward conduction voltage, can be by negative
The value of voltage controls at relatively fractional value, is not result in connected metal-oxide-semiconductor PN junction forward conduction, thus effectively solves electric capacity C1 right-hand member and bear
Pressure produces the problem brought.
In one embodiment, triode transistor is used to replace metal-oxide-semiconductor, particularly as follows: use transistor base to replace metal-oxide-semiconductor
Grid, transistor collector replaces metal-oxide-semiconductor drain electrode, and transistor emitter replaces metal-oxide-semiconductor source electrode.
In one embodiment, the circuit ultimate principle of device of the present invention is as shown in Figure 1.Pass through switch controlling signal
Electric capacity is carried out discharge and recharge, thus produces the pacemaker impulse of cardiac stimulus.In this example, can produce and heart is carried out three times of electricity
Boost pulse within the voltage of source.By configuring 5 input digit order numbers of DAC module, can produce from 0 to VDD and step-length is
Configurable charging voltage V of 0.1VDAC, it is achieved pacemaker impulse amplitude is fine-tuned.Configurable charging voltage VDACTo electric capacity
Charging, is used for producing pacemaker impulse (multiplication of voltage) within one times of supply voltage；Configurable VDACElectric capacity is charged, electric capacity during electric discharge
Another terminates supply voltage, is used for producing the supply voltage pacemaker impulse (two multiplication of voltages) to two times of supply voltages；Configurable VDACWith
Supply voltage is respectively to two electric capacity chargings, two capacitances in series during electric discharge, another termination when the electric capacity of supply voltage charging discharges
Supply voltage, is used for producing two times of supply voltages to three times supply voltage pacemaker impulse (three multiplication of voltages).Providing three multiplication of voltage pace-makings
During pulse, without diode D1, the electric capacity C1 right-hand member velocity of discharge is more than left end, causes electric capacity C1 right-hand member at the end of electric discharge
Voltage is less than left end voltage.On entering during once charging process, metal-oxide-semiconductor M4 turns off, and metal-oxide-semiconductor M3 turns on, the left end of electric capacity C1
Moved to ground by metal-oxide-semiconductor M3, thus have negative voltage at electric capacity C1 right-hand member and produce, cause its connected metal-oxide-semiconductor PN junction positively biased, caused
Voltage of fighting is unable to reach desired value, thus causes circuit normally to work.The present invention utilizes has less forward conduction voltage
The voltage clamp characteristic of Schottky diode D1, can control the value of negative voltage, at relatively fractional value, to be not result in connected metal-oxide-semiconductor
PN junction forward conduction, thus effectively solve electric capacity C1 right-hand member negative pressure and produce the problem brought.
In one embodiment, as it is shown in figure 1, a kind of pacing circuitry diode negative pressure clamper being applied to cardiac pacemaker
Device includes altogether 9 metal-oxide-semiconductors, 3 resistance, 2 electric capacity, 1 diode.Notice that the scope that the present invention is protected is not limited to
Example described herein.In this example, the metal-oxide-semiconductor that transistor all uses, triode transistor can be used to replace MOS simultaneously
Pipe.In this case, replace metal-oxide-semiconductor grid with transistor base, replace metal-oxide-semiconductor drain electrode with transistor collector, use three poles
Pipe emitter stage replaces metal-oxide-semiconductor source electrode.It is applicable to the cardiac pacing circuitry of cardiac pacemaker as it is shown in figure 1, its work process includes:
The generation of pacemaker impulse (multiplication of voltage), the pacemaker impulse of supply voltage to two times supply voltage (two times within one times of supply voltage
Pressure) generation, the generation of two times of supply voltages to three times supply voltage pacemaker impulse (three multiplication of voltages).
Concrete methods of realizing is: as a example by producing two times of supply voltages to three times supply voltage pacemaker impulse (three multiplication of voltages),
First pacemaker anode or pacemaker shell end are connected to the right pole plate of electric capacity C1, pacemaker negative electrode is connected to metal-oxide-semiconductor M1
Source, heart accesses this circuit through correct polarity path；Metal-oxide-semiconductor M1, M3, M6, M8 grid termination high level, remaining metal-oxide-semiconductor grid
End all connects low level, makes electric capacity C1, C2 charge, has gone up slowly through the upper voltage of 20ms, C1, owing to resistance R2 (plays one
Determine protective effect) it is far longer than R1 and metal-oxide-semiconductor M1 conducting resistance sum, so level V is about arrived in last charging on C1DAC, electric capacity C2
Top crown voltage is about VDD；All metal-oxide-semiconductor grid ends all connect low level, wait about 1ms；Metal-oxide-semiconductor M2, M4, M5, M9 grid termination height
Level, remaining metal-oxide-semiconductor grid termination low level, electric capacity C2 former ground connection one end reconfiguration supply voltage, electric capacity C1, C2 discharged in series, etc.
Effect is zero input response.Thus obtain two times of supply voltages pacemaker impulse to three times of supply voltage hearts.
Similar with three multiplication of voltage pacemaker impulses, for producing two multiplication of voltage pacemaker impulses, in the charging stage, only need to be to electric capacity C1
Charging；At discharge regime, the termination high level conducting of metal-oxide-semiconductor M2, M4, M7 grid, electric capacity C1 former ground connection one end reconfiguration supply voltage is put
Electricity.For producing a multiplication of voltage pacemaker impulse, at discharge regime, metal-oxide-semiconductor M2, M3 grid termination high level, electric capacity C1 discharges.
But, when circuit produces two times of supply voltage to three times supply voltage pacemaker impulse (three multiplication of voltages), electric capacity C1, C2
Discharged in series, owing to electric capacity C1, C2 are unequal, in this example, C1 is 6.8 μ F, and C2 is 10 μ F, thus electric capacity about C1 pole plate is put
Electricity speed is inconsistent, causes the electric discharge of electric capacity C1 right pole plate fast, and the electric discharge of electric capacity C1 left pole plate is slow, thus after identical discharge time,
The left polar plate voltage of electric capacity C1 is higher than the right polar plate voltage of electric capacity C1.Shown in electric capacity C1 both end voltage variable quantity relation such as formula (1),
Wherein, Δ VL, Δ VRBeing respectively electric capacity about C1 polar plate voltage variable quantity, C1, C2 are electric capacity C1, C2 capacitance.
When again giving electric capacity C1 charging transient, electric capacity left pole plate ground connection, owing to electric capacity both end voltage can not change moment, because of
The right pole plate of this electric capacity C1 is pulled to negative voltage.The right pole plate of electric capacity C1 connects polar selecting switch circuit, if negative pressure, is likely to result in pole
Metal-oxide-semiconductor PN junction forward conduction in Sexual behavior mode on-off circuit, causes electric leakage, causes circuit function incorrect.And make again
Charging rate when charging to electric capacity slows down, and causes being unable to reach expection pacemaker impulse amplitude.
Drawn the negative a series of harm brought for solving the right pole plate of electric capacity C1, a conduction voltage drop is less than by the present invention
The diodes in parallel of 400mV at C1 two ends, as it is shown in figure 1, and the conducting voltage of this diode the lowest, the value of negative pressure can be the least,
Charge-discharge performance is the best.When the pressure drop of electric capacity two ends is higher than diode turn-on voltage, diode current flow, electric capacity both end voltage difference quilt
Clamper is in N.Owing to the conduction voltage drop of selected diode is minimum, thus without causing polar selecting switch electricity
Metal-oxide-semiconductor PN junction forward bias in road, and again to the speed of electric capacity charging, and between expection pacemaker impulse amplitude
Error reduces, and circuit can the most normally work.
Fig. 2 is not have electric capacity about C1 polar plate voltage simulation result in the pacing circuitry of diode negative pressure clamp device.?
2.8V supply voltage, under 1K ohm heart ohmic load case, it can be seen that in electric capacity charging finishing time, the right pole plate of electric capacity
Voltage is 3.867V, and the left polar plate voltage of electric capacity is 4.866V, and electric capacity both end voltage difference is about 1V.After electric discharge terminates 1ms, electric capacity is right
Polar plate voltage is-649mV, electric capacity left pole plate ground connection, and voltage is 0V, and electric capacity both end voltage difference is 649mV.Electric capacity both end voltage is poor
Become 649mV from 1V, be due to the right polar plate voltage of electric capacity drawn negative after cause after connect PN junction in polar selecting switch metal-oxide-semiconductor
Forward conduction so that the right polar plate voltage of electric capacity is clamped at-649mV, causes circuit normally to work.
Fig. 3 is electric capacity about C1 polar plate voltage simulation result in the pacing circuitry with diode negative pressure clamp device.?
2.8V supply voltage, under 1K ohm heart ohmic load case, it can be seen that in electric capacity charging finishing time, the right pole plate of electric capacity
Voltage is 4.606V, and the left polar plate voltage of electric capacity is 4.815V, and electric capacity both end voltage difference is about 209mV.After electric discharge terminates 1ms, electricity
Holding right polar plate voltage is-120.2mV, electric capacity left pole plate ground connection, and voltage is 0V, and electric capacity both end voltage difference is 120.2mV.Electric capacity is right
Polar plate voltage is clamped at-120.2mV, compares Fig. 2, and the value of negative pressure is obviously reduced, and is not above PN junction conducting voltage, will not
Cause subsequent conditioning circuit metal-oxide-semiconductor PN junction forward conduction, and electric capacity charging rate is faster, make pacemaker impulse amplitude with desired value by mistake
Subtractive is little, thus circuit can normally work, and performance gets a promotion.
In sum, the present invention is in parallel with producing negative pressure electric capacity by an extremely low diode of conduction voltage drop, utilizes diode
Clamper function, reduces the right pole plate of electric capacity and is drawn negative magnitude of voltage, prevent in follow-up polar selecting switch circuit metal-oxide-semiconductor PN junction just
To conducting, improve and recharge speed, the error reducing and expecting between pacemaker impulse, ensure the correctness of circuit function.With
Time circuit structure simple, low in energy consumption, it is simple to integrated in pacemaker product.
The principle of above-described embodiment merely exemplary explanation present invention and effect thereof, preferred embodiment does not has detailed descriptionthe institute
Some details, are also not intended to the detailed description of the invention that this invention is only described.For a person skilled in the art, do not disobeying
Under the spirit and the scope of the back of the body present invention, any based on the equivalent transformation on the basis of technical solution of the present invention, simple replacement etc. aobvious and
The change being clear to, within belonging to scope.
Claims (10)
1. the pacing circuitry negative pressure clamp device being applied to cardiac pacemaker, it is characterised in that described device includes: pace-making
Circuit and DAC module；
Described pacing circuitry is connected with DAC module；
Described pacing circuitry includes: metal-oxide-semiconductor, diode, resistance and electric capacity；
Described resistance shields；
Described electric capacity utilizes its charge-discharge characteristic to produce pacemaker impulse；
Described metal-oxide-semiconductor is used as switch；
Described diode utilizes its clamping performance to reduce the value of electric capacity negative voltage；
Described DAC module is for regulating the amplitude of pacemaker impulse in pacing circuitry.
Device the most according to claim 1, it is characterised in that: preferably, described resistance includes the first resistance, the second resistance
With the 3rd resistance；
Described electric capacity includes the first electric capacity and the second electric capacity；
Described metal-oxide-semiconductor includes the first to the 9th metal-oxide-semiconductor.
Device the most according to claim 2, it is characterised in that:
In described pacing circuitry, one end of the first resistance is connected with the outfan of DAC module, the other end of the first resistance and
The drain terminal of one metal-oxide-semiconductor is connected；
One end of described second resistance respectively with the source of the first metal-oxide-semiconductor, the second metal-oxide-semiconductor drain terminal is connected with heart negative electrode,
The other end of two resistance and the second metal-oxide-semiconductor source are connected and ground connection；
Described 3rd resistance one end is connected with the 8th metal-oxide-semiconductor source, the other end respectively with the 7th metal-oxide-semiconductor source and the 9th metal-oxide-semiconductor
Drain terminal is connected and connects supply voltage；
One end of described first electric capacity is connected with heart anode or pacemaker shell end, the other end and the 3rd metal-oxide-semiconductor drain terminal and
4th metal-oxide-semiconductor drain terminal is connected；
One end of described second electric capacity is connected with the 5th metal-oxide-semiconductor source and the 8th metal-oxide-semiconductor drain terminal, the other end and the 6th metal-oxide-semiconductor
Drain terminal and the 9th metal-oxide-semiconductor source are connected；
Described diode and the first electric capacity are in parallel.
Device the most according to claim 1, it is characterised in that: the conduction voltage drop of described diode is less than 400mV.
Device the most according to claim 1, it is characterised in that: described DAC module includes 5 input digit order numbers, it is possible to produce
Raw from 0 to VDD and configurable charging voltage V that step-length is 0.1VDAC, it is achieved the regulation to pacemaker impulse amplitude.
Device the most according to claim 5, it is characterised in that: described configurable charging voltage VDACTo the first electric capacity charging,
It is used for producing pacemaker impulse within one times of supply voltage.
Device the most according to claim 6, it is characterised in that: described configurable charging voltage VDACTo the first electric capacity charging,
When the first electric capacity electric discharge, the other end of the first electric capacity is connected with supply voltage, is used for producing supply voltage to two times power supply
The pacemaker impulse of voltage.
Device the most according to claim 7, it is characterised in that: described configurable charging voltage VDACTo the first electric capacity charging,
Second electric capacity is charged by supply voltage simultaneously, when the first electric capacity and the second electric capacity discharge simultaneously, and the first electric capacity and the second electric capacity
Series connection, another termination supply voltage of the second electric capacity, it is used for producing two times of supply voltages pacemaker impulse to three times of supply voltages.
Device the most according to claim 4, it is characterised in that: when the first electric capacity two ends pressure drop is higher than diode turn-on voltage
Time, diode current flow, the first electric capacity both end voltage difference is clamped in N.
10. according to the device described in claim 1-9, it is characterised in that use triode transistor to replace metal-oxide-semiconductor, particularly as follows: make
Replacing metal-oxide-semiconductor grid with transistor base, transistor collector replaces metal-oxide-semiconductor drain electrode, and transistor emitter replaces metal-oxide-semiconductor source
Pole.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610348891.9A CN106063973A (en) | 2016-05-24 | 2016-05-24 | A kind of pacing circuitry negative pressure clamp device being applied to cardiac pacemaker |
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| CN201610348891.9A CN106063973A (en) | 2016-05-24 | 2016-05-24 | A kind of pacing circuitry negative pressure clamp device being applied to cardiac pacemaker |
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| CN201610348891.9A Pending CN106063973A (en) | 2016-05-24 | 2016-05-24 | A kind of pacing circuitry negative pressure clamp device being applied to cardiac pacemaker |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5170806A (en) * | 1989-11-10 | 1992-12-15 | Lewicki Microelectronic Gmbh | Protective circuit |
| CN102369042A (en) * | 2009-03-30 | 2012-03-07 | 麦德托尼克公司 | Physiological signal amplifier with voltage protection and fast signal recovery |
| CN104639107A (en) * | 2014-11-25 | 2015-05-20 | 西安交通大学 | Positive pacing pulse generation circuit applied to cardiac pacemaker |
-
2016
- 2016-05-24 CN CN201610348891.9A patent/CN106063973A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5170806A (en) * | 1989-11-10 | 1992-12-15 | Lewicki Microelectronic Gmbh | Protective circuit |
| CN102369042A (en) * | 2009-03-30 | 2012-03-07 | 麦德托尼克公司 | Physiological signal amplifier with voltage protection and fast signal recovery |
| CN104639107A (en) * | 2014-11-25 | 2015-05-20 | 西安交通大学 | Positive pacing pulse generation circuit applied to cardiac pacemaker |
Non-Patent Citations (1)
| Title |
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| JIE ZHANG ET.: "A Mixed-Signal ASIC for Triple-Chamber Cardiac Pacemakers with Heart Resistance Measurement", 《IEEE ASIAN SOLID-STATE CIRCUITS CONFERENCE》 * |
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