CN106047701A - Close range radioactive ray-induced cancer cell apoptosis model device - Google Patents
Close range radioactive ray-induced cancer cell apoptosis model device Download PDFInfo
- Publication number
- CN106047701A CN106047701A CN201610632698.8A CN201610632698A CN106047701A CN 106047701 A CN106047701 A CN 106047701A CN 201610632698 A CN201610632698 A CN 201610632698A CN 106047701 A CN106047701 A CN 106047701A
- Authority
- CN
- China
- Prior art keywords
- housing
- lifting pin
- cancer cell
- radioactive ray
- particle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/04—Flat or tray type, drawers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/10—Petri dish
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/38—Caps; Covers; Plugs; Pouring means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Cell Biology (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention relates to a close range radioactive ray-induced cancer cell apoptosis model device and belongs to the technical field of biomedical experiment devices. The close range radioactive ray-induced cancer cell apoptosis model device has the advantages of simple structure, stability, reliability, good repeatability, use convenience and low cost. The device comprises a housing and a tray is arranged above the housing. The device is characterized in that particle clamps are radially arranged above the tray from the center to the periphery, a sleeve is arranged in the center in the housing corresponding to the lower part of the tray, an ejector rod is arranged in the sleeve, the upper end of the ejector rod corresponding to particles is radially provided with shield plates and an ejector rotation device is arranged at the lower end in the housing corresponding to the ejector rod.
Description
Technical field
The invention belongs to biomedicine experiment device technique field, be specifically related to one closely Induced by Radioactive Ray cancerous cell
Apoptosis Model device.
Background technology
In primary hepatocarcinoma (hepatocellular carcinoma, HCC) (hereinafter referred to as hepatocarcinoma) is world wide
3rd common cancer.China is the hotspot of hepatocarcinoma, accounts for the 45% of whole world hepatocarcinoma case, there are about 110,000 people every year and die from
Hepatocarcinoma, its mortality rate arranges the 2nd (26.26/10 ten thousand) in China, and the serious threat people is healthy.At present, early operation excision
It is still the Main Means for the treatment of hepatocarcinoma, but, major part patient has been in hepatocarcinoma progressive stage when clarifying a diagnosis, has surgical engine meeting
Only account for 10～about 20%, traditional external radiation treatment is due to the normal liver tissue the limited curative effect of sensitivity to ray
And bad, and systemic chemotherapeutic effect is the most very limited, and with huge side effect.
Hepatocarcinoma has proven to be a kind of radiosensitive tumor.Lonizing radiation can induce cancerous cell DNA damage to send out
Raw apoptosis.Along with new radiation therapy technology and the appearance of equipment, brachytherapy (as125I、60Co、226Ra、103Pd seeds implanted is treated) increasingly receive significant attention.Seeds implantation is to carry out tumor shining in closely
A kind of mode penetrated, has the advantages such as Wicresoft, simplicity, efficient, side effect is little(10).The radioactivity that maximum can be measured by it is strong
The direct throwing of degree shines tumor itself, and normal surrounding tissue is by the lowest according to metering, and the high dose of this local can be to sensitivity
Tumor plays the effect for the treatment of, and toxicity and the acute radiation damage suffered by normal surrounding tissue is less.Radioactive particle is planted
Entering the treatment history of the most about 100 years, record the earliest originates from 19th-century nineties, is applied to clinic in early days
Radioactive particle is some high-energy radioactive nucleic, as etc..Due to high energy r-radiation protection difficulty, occur in that the most serious
Side reaction, the most this clinical treatment means are restricted, but within nearest 20 years, have engendered some mental retardation radioactivity grains
Son, as125I、103Pd etc., these have all expanded the radioactive particle application in treatment field.125I particle is that airtight treatment connects most
Being bordering on Utopian radionuclide, single radioactivity is 0.3～1.0mCi, and its half-life is 60.2 days, and energy is
27.4～31.4Kv(X lines), 35.5Kv(r ray).Its largest body internal radiation scope about 1.7cm.Owing to being easy to preserve, the most right
Patient and medical worker's damage are less, and the method that the internal implantable brachytherapy of this radioactive particle irradiates is the most gradually at clinical position
In be widely accepted.
Shengjing Hospita of China M Edical University radiology department carries out for 2005125Since the treatment of I seeds implanted, have accumulated abundant facing
Bed experience, in the about 1800 example liver cancer patients that 2005-2009 accepts for medical treatment, follow-up time is 18 months, and survival rate is about
68.3%, Qi Zhonghang125In the patient of I seeds implanted treatment, survival rate is 85.4%, objective effective percentage about 72.5%, to a certain degree
On improve the clinical therapeutic effect to hepatocarcinoma.But,125The treatment of I seeds implanted is not universality (the One size of
Fits all) Therapeutic Method.Find hepatocarcinoma clinically125The effect individual variation of I particle brachytherapy is very big, about 40～
The patient for treatment of about 50% is insensitive, the hepatocarcinoma pair of different pathological types125There is significance difference in I seeds implanted therapeutic sensitivity
Different, the hepatocarcinoma of the most same histological type also has different radiosensitivities at different patients.After the treatment of these cases
Corresponding pathological manifestations can continue to progress from from cases of complete remission to disease, differs a lot of.Due at present conventional laboratory and
Image check there is no method and detects each liver cancer patient sensitivity to radiation, if need to accept125I seeds implanted is treated
Selection standard still rely on the personal experience of clinician, the liver cancer patient not only resulting in quite a few ray insensitive connects
It is subject to125I seeds implanted is treated, and brings unnecessary financial burden and local radiotoxicity to react to patient, and to a certain degree
On also delay other treatment means application opportunity, occur tumour progression, operation prognosis be deteriorated.Therefore, searching is quick with ray
The biological markers that perception is relevant, to screening liver cancer patient, it is to avoid invalid, excessive treatment, has important
Clinical meaning.At present for closely radiation cure, especially125The relevant sensitivity molecular mechanism state of the apoptosis-induced damage of I
Inside and outside still rarely have report.
And penetrate the molecule mechanism of closely radiation-sensitive to preferably study cancerous cell including hepatocarcinoma
Line damage repair mechanism, needs to set up a kind of irradiation at short distance apoptosis damage model.This device can simulate people in vitro
Body cancerous tumor cell or normal cell damage for the apoptosis of close-range particle Induced by Radioactive Ray.Thus carry out malignant cell and support
The researchs such as the molecular mechanism of anti-Induced by Radioactive Ray apoptosis and hypersitization medicine research and development experiment.The most domestic still do not have business-like closely
Distance Induced by Radioactive Ray apoptosis damage model occurs.The external existing usual structure of cell irradiation damaging device is complicated, if
Standby cost is sufficiently expensive, and this causes obstruction to China's correlational study.Therefore develop one and there is independent intellectual property right, economical,
Practical mould, it will promote China in the progress of association area greatly.This device will assist in and finds the ideal of clinic to put
Radiation-sensitive molecular prediction index.
Summary of the invention
The present invention is aiming at the problems referred to above, it is provided that a kind of simple in construction, reliable and stable, repeatable strong, easy to use,
Closely Induced by Radioactive Ray cancer cell-apoptosis model equipment with low cost.
In order to realize the above-mentioned purpose of the present invention, the present invention adopts the following technical scheme that, the present invention includes housing, on housing
Side is provided with pallet, it is characterised in that: above pallet, by center, outwards in radial line, arrangement is provided with particle folder, housing internal phase
Should be provided centrally with sleeve below pallet, be provided with lifting pin in sleeve, lifting pin upper end presss from both sides in radiation corresponding to particle
Wire is provided with shutter, and in described housing, the lower end corresponding to lifting pin is provided with jacking-rotating device.
As a preferred embodiment of the present invention, when lifting pin drops to minimum point, lifting pin and shutter upper surface
Height height when installing radioactive particle upper less than particle folder；When lifting pin rises to peak, lifting pin and blocking
Plate upper surface height is more than height during particle folder upper installation radioactive particle.
As the another kind of preferred version of the present invention, described pallet side is provided with support bar, arranges corresponding to support bar
There is upper cover.
As the third preferred version of the present invention, described jacking-rotating device includes the gathering sill being arranged on sleeve,
Being provided with the guide post coordinated with gathering sill on lifting pin, described gathering sill bottom is vertical section, and gathering sill top is tilting section；
In housing, the lower end corresponding to lifting pin is provided with jacking apparatus.
Beneficial effects of the present invention: 1, present configuration is simple, low production cost can realize large-scale production, and,
The present invention can be repeatedly used for a long, and considerably reduces the equipment cost of Induced by Radioactive Ray cancer cell-apoptosis test.
2, when the present invention uses, by jacking-rotating device, the shutter on lifting pin can be lifted, and turn to radiation
Above property particle, when medical worker checks cell state, the radiation that maskable radioactive particle sends, thus increase substantially
The safety of test.
3, the present invention is when lifting pin drops to minimum point, and the height of lifting pin and shutter upper surface is less than on particle folder
Height during radioactive particle is installed；Tissue Culture Dish can be directly placed on radioactive particle, from the nearest distance pair
Cell radiates such that it is able to the accurate simulation body radioactivity particle radiation to cell.
4, after radioactive particle is blocked by the shutter of the present invention, cell can be made to stop accepting radiation；When on lifting pin
When being raised to peak, Tissue Culture Dish can be lifted certain altitude by lifting pin and shutter, due to the irradiation model of radioactive particle
Enclose only 1.7cm, therefore, the radioactive particle impact on culture dish inner cell can be eliminated further.
5, the present invention arranges upper cover by support bar, can prevent the radiation leakage in pallet, again can be to Tissue Culture Dish
In ventilative, meet the requirement that cell is cultivated.
6, the present invention is by the way of arranging gathering sill and guiding lifting pin, can readily realize radioactive particle
Block and decontrol, significantly simplify structure, thus production cost is greatly lowered.
Accompanying drawing explanation
Fig. 1 is the structural representation of the present invention.
Fig. 2 is the embodiment of the present invention 1 lifting pin structural representation when being positioned at minimum point.
Fig. 3 is the embodiment of the present invention 1 lifting pin structural representation when being positioned at peak.
Fig. 4 is the embodiment of the present invention 2 lifting pin structural representation when being positioned at minimum point.
Fig. 5 is the embodiment of the present invention 2 lifting pin structural representation when being positioned at peak.
Fig. 6 is shutter and the structural representation of particle folder interleaved state of the present invention.
Fig. 7 is that particle is pressed from both sides structural representation when sheltering from by the shutter of the present invention.
Accompanying drawing 1 is housing, 2 is jacking-rotating device, 3 is lifting pin, 4 is sleeve, 5 is pallet, 6 is support bar, 7 is
Upper cover, 8 be Tissue Culture Dish, 9 for radioactive particle, 10 for shutter, 11 for particle folder, 12 for guidance panel, 13 for guiding
Groove, 14 be guide post, 15 be lever, 16 be limiting card, 17 for electric pushrod.
Detailed description of the invention
The present invention includes that housing 1, housing 1 are provided above pallet 5, it is characterised in that: above pallet 5 by center outwards in
Radial line arrangement is provided with particle folder 11, corresponding to being provided centrally with sleeve 4 below pallet 5 in housing 1, sets in sleeve 4
Being equipped with lifting pin 3, lifting pin 3 upper end is provided with shutter 10 corresponding to particle folder 11 in radial line, corresponding in described housing 1
The lower end of lifting pin 3 is provided with jacking-rotating device 2.
It is provided with the guidance panel 12 of jacking-rotating device 2 on described housing 1, jacking-rotating device is provided with timing
Device.
As a preferred embodiment of the present invention, when lifting pin 3 drops to minimum point, on lifting pin 3 and shutter 10
The height of end face presss from both sides height when installing radioactive particle 9 on 11 less than particle；When lifting pin 3 rises to peak, jacking
Bar 3 and shutter 10 upper surface height press from both sides height when installing radioactive particle 9 on 11 more than particle.
As the another kind of preferred version of the present invention, described pallet 5 side is provided with support bar 6, sets corresponding to support bar 6
It is equipped with upper cover 7.
As the third preferred version of the present invention, described jacking-rotating device 2 includes the gathering sill being arranged on sleeve 4
13, lifting pin 3 is provided with the guide post 14 coordinated with gathering sill 13, described gathering sill 13 bottom is vertical section, gathering sill 13
Top is tilting section；In housing 1, the lower end corresponding to lifting pin 3 is provided with jacking apparatus.
During use, jacking apparatus is by lifting pin 3 jack-up, owing to guide post 14 matches with the vertical section of gathering sill 13, and top
Rising stem 3 first moves straight up, then under the effect of guide post 14 and gathering sill 13 tilting section, rotates and rises, shutter 10
Turn an angle, radioactive particle 9 is blocked completely.
Embodiment 1: described jacking apparatus includes the lever 15 being arranged in housing 1, one end of lever 15 and lifting pin 3
Lower end is corresponding, and the other end of lever 15 stretches out outside housing 1, and housing 1 is provided with limiting card 16 corresponding to lever 15.
Embodiment 2: described jacking apparatus includes the electric pushrod 17 being arranged in housing 1, electric pushrod 17 and lifting pin 3
Lower end corresponding.
Further, described electric pushrod 17 is provided with timing means.After completing to set irradiation time, it is right to automatically cut off
The irradiation of cell, has automatization's feature, it is not necessary to professional nurses.
The guidance panel 12 of electric pushrod 17 it is provided with on described housing 1.
The present invention can use small-sized electric push rod 17, its advantage with low energy consumption, it is only necessary to charged lithium cells can complete
Drive.
Described pallet 5 and upper cover 7 are made by lead glass material, can shield radioactive particle 9 completely to experimenter
Damage, is also convenient for operator and observes.
It addition, the present invention can carry out high temperature sterilize sterilization, it is to avoid pathogenic microorganism is to cultivating cell contamination.
Compact of the present invention, and there is lead glass outer housing shield ray completely, can be positioned in cell culture incubator, with
Time avoid to other cultivate cell impact.
Described particle folder 11 is set to elastic clip.Be easy to radioactive particle 9 is installed on dismounting.
It is understood that above with respect to the specific descriptions of the present invention, be merely to illustrate the present invention and be not limited to this
Technical scheme described by inventive embodiments, it will be understood by those within the art that, still can carry out the present invention
Amendment or equivalent, to reach identical technique effect；As long as meet use needs, all protection scope of the present invention it
In.
Claims (10)
1. a closely Induced by Radioactive Ray cancer cell-apoptosis model equipment, including housing (1), housing (1) is provided above torr
Dish (5), it is characterised in that: by center, outwards in radial line, arrangement is provided with particle folder (11), housing (1) in pallet (5) top
In corresponding to pallet (5) lower section be provided centrally with sleeve (4), be provided with lifting pin (3), lifting pin (3) upper end in sleeve (4)
Press from both sides (11) corresponding to particle and be provided with shutter (10) in radial line, the interior lower end corresponding to lifting pin (3) of described housing (1)
It is provided with jacking-rotating device (2).
One the most according to claim 1 closely Induced by Radioactive Ray cancer cell-apoptosis model equipment, it is characterised in that: institute
State the guidance panel (12) being provided with jacking-rotating device (2) on housing (1), jacking-rotating device is provided with intervalometer.
One the most according to claim 1 closely Induced by Radioactive Ray cancer cell-apoptosis model equipment, it is characterised in that: when
When lifting pin (3) drops to minimum point, the height of lifting pin (3) and shutter (10) upper surface is upper less than particle folder (11) to be installed
Height during radioactive particle (9)；When lifting pin (3) rises to peak, lifting pin (3) and shutter (10) upper surface are high
Degree presss from both sides height when installing radioactive particle (9) on (11) more than particle.
One the most according to claim 1 closely Induced by Radioactive Ray cancer cell-apoptosis model equipment, it is characterised in that: institute
State pallet (5) side and be provided with support bar (6), support bar (6) is provided with upper cover (7).
One the most according to claim 1 closely Induced by Radioactive Ray cancer cell-apoptosis model equipment, it is characterised in that: institute
Stating the gathering sill (13) that jacking-rotating device (2) includes being arranged on sleeve (4), lifting pin is provided with and gathering sill on (3)
(13) guide post (14) coordinated, described gathering sill (13) bottom is vertical section, and gathering sill (13) top is tilting section；Housing
(1) in, the lower end corresponding to lifting pin (3) is provided with jacking apparatus.
One the most according to claim 5 closely Induced by Radioactive Ray cancer cell-apoptosis model equipment, it is characterised in that: institute
Stating the lever (15) that jacking apparatus includes being arranged in housing (1), one end of lever (15) is relative with the lower end of lifting pin (3)
Should, the other end of lever (15) stretches out housing (1) outward, and housing (1) is provided with limiting card (16) corresponding to lever (15).
One the most according to claim 5 closely Induced by Radioactive Ray cancer cell-apoptosis model equipment, it is characterised in that: institute
Stating the electric pushrod (17) that jacking apparatus includes being arranged in housing (1), electric pushrod (17) is relative with the lower end of lifting pin (3)
Should.
One the most according to claim 7 closely Induced by Radioactive Ray cancer cell-apoptosis model equipment, it is characterised in that: institute
State and be provided with timing means on electric pushrod (17).
One the most according to claim 1 closely Induced by Radioactive Ray cancer cell-apoptosis model equipment, it is characterised in that: institute
State pallet (5) and upper cover (7) is made by lead glass material.
One the most according to claim 1 closely Induced by Radioactive Ray cancer cell-apoptosis model equipment, it is characterised in that:
Described particle folder (11) is set to elastic clip.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610632698.8A CN106047701B (en) | 2016-08-05 | 2016-08-05 | A kind of short distance Induced by Radioactive Ray cancer cell-apoptosis model equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610632698.8A CN106047701B (en) | 2016-08-05 | 2016-08-05 | A kind of short distance Induced by Radioactive Ray cancer cell-apoptosis model equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106047701A true CN106047701A (en) | 2016-10-26 |
| CN106047701B CN106047701B (en) | 2018-08-07 |
Family
ID=57196416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610632698.8A Active CN106047701B (en) | 2016-08-05 | 2016-08-05 | A kind of short distance Induced by Radioactive Ray cancer cell-apoptosis model equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106047701B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114120803A (en) * | 2020-08-26 | 2022-03-01 | 江苏实信智能科技有限公司 | Be applied to bus stop borad on driving road of examining |
| CN117551549A (en) * | 2024-01-12 | 2024-02-13 | 中国人民解放军总医院海南医院 | Seawater nuclear radiation tumor cell canceration period measurement equipment and method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102604829A (en) * | 2012-03-13 | 2012-07-25 | 合肥聚能电物理高技术开发有限公司 | Rotary adjustable alpha-source irradiation device |
| CN102839123A (en) * | 2012-09-02 | 2012-12-26 | 云南省肿瘤医院 | Device for 125I particle cell irradiation experiment |
| CN205933841U (en) * | 2016-08-05 | 2017-02-08 | 中国医科大学附属盛京医院 | Closely cancer apoptosis model device is inductiond to radioactive ray |
-
2016
- 2016-08-05 CN CN201610632698.8A patent/CN106047701B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102604829A (en) * | 2012-03-13 | 2012-07-25 | 合肥聚能电物理高技术开发有限公司 | Rotary adjustable alpha-source irradiation device |
| CN102839123A (en) * | 2012-09-02 | 2012-12-26 | 云南省肿瘤医院 | Device for 125I particle cell irradiation experiment |
| CN205933841U (en) * | 2016-08-05 | 2017-02-08 | 中国医科大学附属盛京医院 | Closely cancer apoptosis model device is inductiond to radioactive ray |
Non-Patent Citations (3)
| Title |
|---|
| MA ET AL.: "Continuous and low-energy 125I seed irradiation changes DNA methyltransferases expression patterns and inhibits pancreatic cancer tumor growth", 《JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH》 * |
| 嵇卫星等: "一种用于细胞实验的新型α粒子照射装置的建造和验证", 《辐射研究与辐射工艺学报》 * |
| 王济东等: "放射性125 I粒子离体照射模型的建立和测量", 《中华放射医学与防护杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114120803A (en) * | 2020-08-26 | 2022-03-01 | 江苏实信智能科技有限公司 | Be applied to bus stop borad on driving road of examining |
| CN117551549A (en) * | 2024-01-12 | 2024-02-13 | 中国人民解放军总医院海南医院 | Seawater nuclear radiation tumor cell canceration period measurement equipment and method |
| CN117551549B (en) * | 2024-01-12 | 2024-04-05 | 中国人民解放军总医院海南医院 | Seawater nuclear radiation tumor cell canceration period measurement equipment and method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106047701B (en) | 2018-08-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Stewart et al. | Current controversies in high‐dose‐rate versus low‐dose‐rate brachytherapy for cervical cancer | |
| Kakimoto et al. | Results of low-and high-dose-rate interstitial brachytherapy for T3 mobile tongue cancer | |
| Marra et al. | Survival after radiation therapy for high-grade glioma | |
| CN106047701A (en) | Close range radioactive ray-induced cancer cell apoptosis model device | |
| CN205933841U (en) | Closely cancer apoptosis model device is inductiond to radioactive ray | |
| CN201324447Y (en) | Neutron brachytherapy system | |
| CN206337278U (en) | A kind of device for radion closely radiation-induced cellular damage | |
| CN204469034U (en) | A kind of tumor radiotherapy bed | |
| CN213142048U (en) | Cell culture I125Automatic particle irradiation box | |
| CN108815173A (en) | A method of prostate gland cancer cell is captured to drug using light forceps device | |
| CN201312969Y (en) | Gamma knife | |
| CN108310173A (en) | A kind of Chinese medicine preparation of auxiliary treatment early-stage cancer and its preparation method of oral solution | |
| CN106520548B (en) | A kind of device for the radiation-induced cellular damage of radion short distance | |
| CN206139160U (en) | Loading attachment of radion | |
| CN105777790A (en) | O-carborane phenol derivative as well as preparation method and application thereof | |
| Doi et al. | Experimental animal model of re-irradiation to evaluate radiation-induced damage in the normal intestine | |
| CN213172366U (en) | Cell culture I125Automatic particle irradiation box | |
| CN211513172U (en) | Tumor radiotherapy positioner | |
| CN202119915U (en) | Support for measuring equivalent radioactivity of sealed seed source | |
| CN115645532B (en) | Application of isoxazole derivative in preparing brain glioma radiotherapy sensitization drugs | |
| CN212800388U (en) | Cell culture I125Automatic particle irradiation box | |
| CN212730746U (en) | High oncology radiotherapy machine of security | |
| Franca et al. | Radioactive seed migration after prostate brachytherapy with iodine-125 using loose seeds versus stranded seeds | |
| CN107224580A (en) | Application of the class a-amino acid boron trifluoride compound in boron neutron capture therapy | |
| CN100404075C (en) | Preparation method of interpose internal radiation anti tumour series medicine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |