CN102604829A - Rotary adjustable alpha-source irradiation device - Google Patents

Rotary adjustable alpha-source irradiation device Download PDF

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Publication number
CN102604829A
CN102604829A CN201210064552XA CN201210064552A CN102604829A CN 102604829 A CN102604829 A CN 102604829A CN 201210064552X A CN201210064552X A CN 201210064552XA CN 201210064552 A CN201210064552 A CN 201210064552A CN 102604829 A CN102604829 A CN 102604829A
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Prior art keywords
irradiation
source
revolving dial
adjustable
retaining plate
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CN201210064552XA
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CN102604829B (en
Inventor
吴杰锋
刘志宏
薛延河
陈建林
张怀斌
商明明
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HEFEI JUNENG ELECTRO PHYSICS HIGH-TECH DEVELOPMENT Co Ltd
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HEFEI JUNENG ELECTRO PHYSICS HIGH-TECH DEVELOPMENT Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06—Plates; Walls; Drawers; Multilayer plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/04—Flat or tray type, drawers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/10—Rotating vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M31/00—Means for providing, directing, scattering or concentrating light
    • C12M31/12—Rotating light emitting elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Particle Accelerators (AREA)

Abstract

The invention discloses a rotary adjustable alpha-source irradiation device which is characterized by comprising a bracket, a rotary platform erected on the bracket, a plurality of sample culture dishes arranged on the rotary platform, a liftable alpha-source irradiation mechanism erected on the bracket below the rotary platform, wherein the rotary platform is driven by a motor. The rotary adjustable alpha-source irradiation device is reasonable in design, the irradiation dose on the cell is adjusted by adjusting the height of the irradiation source, the rotation speed of the sample platform and the angle of a sample outlet, the fabrication cost is low, the irradiation device can perform the linear energy transfer (LET) irradiation in different doses, and different dosage rates, the irradiation dose is accurate and the irradiation controllability is good.

Description

The adjustable α of a kind of rotation source irradiating unit
Technical field
The present invention relates to the adjustable α of a kind of rotation source irradiating unit, it be used for studying particle the radiation effect of cell with and mechanism.
Background technology
Along with development of science and technology, low dosage, LDR radiating hazardness more and more receive people's attention in the environment.Calculating according to D.Brenner; The radiation of the alpha-particle of radon gas that human body is suffered and filial generation radiation thereof accounts for 55% of the suffered total environment radiation quantity of human body; For radiation effect and the mechanism thereof of studying alpha-particle; Radiation biology man has developed various α source irradiating unit, can be divided into alpha-particle that produces through accelerator and the dual modes such as alpha-particle that produce through radioactive source at present.The former advantage is to carry out various dose, dose rate and LET irradiation, and irradiation dose is accurate, and controllability is good, but involves great expense.Latter's inexpensive, relatively low to technical requirements, but this device is difficult to reach our requirement to low dosage and low dose rate irradiation owing to adopt the dose irradiation mode of fast gate control.Therefore need a kind of αLi Zizhaoshe device that can accurately control irradiation dose.
Summary of the invention
The objective of the invention is in order to remedy the deficiency of prior art, the adjustable α of a kind of rotation source irradiating unit is provided, solved existing α source irradiating unit; Can not have inexpensive simultaneously, can carry out various dose, dose rate and LET irradiation; Performances such as irradiation dose is accurate, and controllability is good.
The present invention realizes through following technical scheme:
The adjustable α of a kind of rotation source irradiating unit; It is characterized in that: include support; Said support is put on the shelf and is provided with revolving dial; Said revolving dial is provided with a plurality of sample cultivation wares, and the support of said revolving dial below is put on the shelf and is provided with liftable α source irradiation means, and said revolving dial is by electric motor driving.
Described sample cultivation ware is circular, and is distributed on the revolving dial.
Described liftable α source irradiation means includes retaining plate; On the said retaining plate αFang Sheyuan is installed; Said retaining plate lower end is installed with guide rod; The bottom of said guide rod is fixedly mounted on the nut permanent seat, and the driven by motor precision ball screw that moves through of said nut permanent seat drives.
The support of described retaining plate below is provided with strongback, and said strongback middle part is provided with pilot hole, has said guide rod to pass in the said pilot hole.
Rotate the object that adjustable α source irradiating unit shines needs and be placed in the petridish of sample table in experimentation, its principle is to carry out the radioactive source height according to the size of its needed radiation quantity, the adjusting of sample table rotating speed and particle exit angle; Through adjusting radioactive source height, the sample table rotating speed, the suffered radiating dosage of mode pair cell such as particle exit angle are regulated.The up and-down movement of radioactive source is to accomplish through the precision ball screw of bottom, and the maximal regulated amount is 137mm, and positional precision is 0.05mm.Therefore being realized by servomotor drive speed reduction unit of example platform can accurately regulate the speed of rotation of platform.The slit template in particle exit can be replaced, thereby guarantees that its exit angle can carry out conversion between 1～7 degree.
Described sample table once can be placed many group samples; Sample table drives the mode of worm type of reduction gearing along being rotated through servomotor; Thereby sample is shone through the outlet in α source successively, thus through the adjustment servomotor rotating speed can to sample in the unit time irradiation number of times through the α source regulate.The irradiation exit gap size in α source is controlled by dedicated templates, can regulate the exit angle of particle through the mode of changing template.Therefore, all can regulate through above three kinds of modes the suffered radiating dosage of pair cell.
Advantage of the present invention is:
The present invention is reasonable in design, through regulating radioactive source height, sample table rotating speed; The suffered radiating dosage of mode pair cell such as particle exit angle are regulated, and have inexpensive, can carry out various dose; Performances such as dose rate and LET shine, and irradiation dose is accurate, and controllability is good.
Description of drawings
Fig. 1 is master's sectional view of the present invention.
Fig. 2 is a vertical view of the present invention.
Embodiment
Referring to accompanying drawing, a kind of rotation is adjustable α source irradiating unit includes support 1; Support 1 is put on the shelf and is provided with revolving dial 2; Revolving dial 2 is provided with a plurality of sample cultivation wares 3, and the support 1 of revolving dial 2 belows is put on the shelf and is provided with liftable α source irradiation means 4, and revolving dial 4 is driven by motor 5; Described sample cultivation ware 3 is circular, and is distributed on the revolving dial 2; Described liftable α source irradiation means 4 includes retaining plate 6; αFang Sheyuan 7 is installed on the retaining plate 6; Retaining plate 6 lower ends are installed with guide rod 8, and the bottom of guide rod 8 is fixedly mounted on the nut permanent seat 11, and the driven by motor precision ball screw 9 that moves through of nut permanent seat 11 drives; The support of described retaining plate 6 belows is provided with strongback 10, and strongback 10 middle parts are provided with pilot hole, has guide rod 8 to pass in the said pilot hole.

Claims (4)

1. one kind is rotated adjustable α source irradiating unit; It is characterized in that: include support; Said support is put on the shelf and is provided with revolving dial; Said revolving dial is provided with a plurality of sample cultivation wares, and the support of said revolving dial below is put on the shelf and is provided with liftable α source irradiation means, and said revolving dial is by electric motor driving.
2. the adjustable α of a kind of rotation according to claim 1 source irradiating unit is characterized in that: described sample cultivation ware is circle, and is distributed on the revolving dial.
3. the adjustable α of a kind of rotation according to claim 1 source irradiating unit; It is characterized in that: described liftable α source irradiation means includes retaining plate; On the said retaining plate αFang Sheyuan is installed; Said retaining plate lower end is installed with guide rod, and the bottom of said guide rod is fixedly mounted on the nut permanent seat, and the driven by motor precision ball screw that moves through of said nut permanent seat drives.
4. the adjustable α of a kind of rotation according to claim 1 source irradiating unit is characterized in that: the support of described retaining plate below is provided with strongback, and said strongback middle part is provided with pilot hole, has said guide rod to pass in the said pilot hole.
CN 201210064552 2012-03-13 2012-03-13 Rotary adjustable alpha-source irradiation device Expired - Fee Related CN102604829B (en)

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Application Number Priority Date Filing Date Title
CN 201210064552 CN102604829B (en) 2012-03-13 2012-03-13 Rotary adjustable alpha-source irradiation device

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Application Number Priority Date Filing Date Title
CN 201210064552 CN102604829B (en) 2012-03-13 2012-03-13 Rotary adjustable alpha-source irradiation device

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CN102604829A true CN102604829A (en) 2012-07-25
CN102604829B CN102604829B (en) 2013-10-09

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102839123A (en) * 2012-09-02 2012-12-26 云南省肿瘤医院 Device for 125I particle cell irradiation experiment
CN103820317A (en) * 2014-01-21 2014-05-28 苏州大学 Alpha source irradiation device for cell experiments
CN106047701A (en) * 2016-08-05 2016-10-26 中国医科大学附属盛京医院 Close range radioactive ray-induced cancer cell apoptosis model device
CN106520548A (en) * 2016-10-17 2017-03-22 中国医科大学附属盛京医院 Device for radioactive ion to radiate and induce cell for damaging at short distance
CN108179111A (en) * 2017-12-30 2018-06-19 郑州赫恩电子信息技术有限公司 A kind of anti-ageing scintilloscope of hand-held plasma
CN109207365A (en) * 2018-11-06 2019-01-15 中国医科大学附属盛京医院 A kind of cancer cell irradiation experiment cell culture apparatus

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US3721825A (en) * 1970-12-03 1973-03-20 J Rasmussen Method and apparatus for analysis of liquid residues using nuclear reactions
CN1450846A (en) * 2002-10-26 2003-10-22 中国科学院等离子体物理研究所 Method and device for producing single particle nano beam
CN202658160U (en) * 2012-03-13 2013-01-09 合肥聚能电物理高技术开发有限公司 Rotary adjustable alpha source irradiating device

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US3721825A (en) * 1970-12-03 1973-03-20 J Rasmussen Method and apparatus for analysis of liquid residues using nuclear reactions
CN1450846A (en) * 2002-10-26 2003-10-22 中国科学院等离子体物理研究所 Method and device for producing single particle nano beam
CN202658160U (en) * 2012-03-13 2013-01-09 合肥聚能电物理高技术开发有限公司 Rotary adjustable alpha source irradiating device

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《辐射防护》 19960531 张欣 等 用于细胞放射生物学研究的alpha照射模型 192-202 1-4 第16卷, 第03期 *
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张欣 等: "用于细胞放射生物学研究的α照射模型", 《辐射防护》, vol. 16, no. 03, 31 May 1996 (1996-05-31), pages 192 - 202 *
时钟涛等: "单粒子束装置", 《现代物理知识》, no. 01, 31 December 2003 (2003-12-31), pages 31 - 32 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102839123A (en) * 2012-09-02 2012-12-26 云南省肿瘤医院 Device for 125I particle cell irradiation experiment
CN103820317A (en) * 2014-01-21 2014-05-28 苏州大学 Alpha source irradiation device for cell experiments
CN103820317B (en) * 2014-01-21 2015-08-19 苏州大学 For the α source irradiating unit of cell experiment
CN106047701A (en) * 2016-08-05 2016-10-26 中国医科大学附属盛京医院 Close range radioactive ray-induced cancer cell apoptosis model device
CN106047701B (en) * 2016-08-05 2018-08-07 中国医科大学附属盛京医院 A kind of short distance Induced by Radioactive Ray cancer cell-apoptosis model equipment
CN106520548A (en) * 2016-10-17 2017-03-22 中国医科大学附属盛京医院 Device for radioactive ion to radiate and induce cell for damaging at short distance
CN106520548B (en) * 2016-10-17 2018-09-25 中国医科大学附属盛京医院 A kind of device for the radiation-induced cellular damage of radion short distance
CN108179111A (en) * 2017-12-30 2018-06-19 郑州赫恩电子信息技术有限公司 A kind of anti-ageing scintilloscope of hand-held plasma
CN109207365A (en) * 2018-11-06 2019-01-15 中国医科大学附属盛京医院 A kind of cancer cell irradiation experiment cell culture apparatus

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