CN106039382A - Glucan-based transparent hydrogel dressing and preparation method thereof - Google Patents
Glucan-based transparent hydrogel dressing and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention provides a glucan-based transparent hydrogel dressing and a preparation method thereof. The preparation method of the glucan-based transparent hydrogel dressing comprises the following steps: conducting a reaction between a glucan quaternary ammonium salt derivative and succinic anhydride; then promoting an obtained product to react with small molecules of amination, so that a macromonomer which contains illuminated cross-linking double bonds is obtained; mixing the macromonomer which contains illuminated cross-linking double bonds with an antibacterial agent and an initiating agent; conducting photo initiation so as to prepare a glucan-based transparent hydrogel; and combining the glucan-based transparent hydrogel with a polyurethane film by virtue of a bonding agent, so that the glucan-based transparent hydrogel dressing is prepared. The finished product (the glucan-based transparent hydrogel dressing) prepared by the invention not only can absorb a great amount of wound exudates so as to keep a wound surface wet, but also can avoid wound adhesion, so that the probability of wound infection is reduced and wound surface healing is promoted.
Description
Technical field
The invention belongs to fabrics for industrial use technical field, particularly relate to a kind of novel glucosan base transparent aquagel multiple
Close dressing.
Background technology
Proposition that Winter moisture treatment in 1962 is theoretical and confirmation indicate the beginning of " moist dressing " revolution, from that with
Rear many scholars, for many shortcomings of gauze dressing, have carried out long-term research to dressing, it is desirable to research and develop treatment effect
Fruit preferably dressing.Film dressing can stop antibacterial to infect, it is provided that gas exchange, has the advantages such as good mechanical performance,
But its moisture-vapor transmission is the least, and water absorbing properties is not good enough, easily causes sepage accumulation under film, may induce or add reinfection
Dye, so being only suitable for the less wound of transudate.Cystose dressing absorbability is good, and water vapo(u)r transmission is good, but wound surface
Granulation tissue is easily grown into, and causes demoulding difficulty, and easily by germ contamination.
Aerogel dressing is a kind of moist dressing, it has the advantage that soft, good springiness, can absorb a large amount of wound and ooze
Go out liquid, keep wound surface moistening, and do not result in the hydrops between dressing and wound surface；Prevent tissue dewatering and apoptosis, accelerate
Vascularization；Protection wound surface resists penetrating of extraneous antibacterial, reduces wound infection chance；Air-and water-permeable, oxygen, moisture can pass through
Gel arrives wound, keeps, promotes granulation and epithelial tissue normal growth, wound healing, preventing from scar；Aerogel dressing
With hydration repeatedly can occur during contact tissue, the moisture absorption in tissue in dressing, can the oozing of continuous absorption wound surface
Go out thing, absorb the hydrogel not contaminated wound of exudate, it is possible to need not more change dressings in about 3-7 days, hence it is evident that subtract
Lack the number of times changed dressings.It addition, aerogel dressing can be designed to transparence, doctor can observe wound at any time through gel and become
Change situation, adjusts dosage in time.Its feature of aerogel dressing is close to the requirement of preferable dressing, so applying hydrogel both at home and abroad
The research of material is in the ascendant.
Summary of the invention
It is an object of the invention to provide the transparent aquagel dressing of a kind of biocompatibility and product having enhanced antibacterial action, can absorb
A large amount of wound fluids, keep wound surface moistening, again can adhesion wound, reduce wound infection chance, wound healing.
In order to achieve the above object, the invention provides a kind of glucosan base transparent aquagel dressing, it is characterised in that
Including carrier and the glucosan base transparent aquagel be located on carrier, containing antibacterial in described glucosan base transparent aquagel
Medicine.
Preferably, described carrier is polyurethane film.
Present invention also offers the preparation method of above-mentioned glucosan base transparent aquagel dressing, it is characterised in that including:
Glucosan quaternary ammonium salt derivative is reacted with succinic anhydride, then products therefrom is reacted with amidized little molecule, contained
Can the macromonomer of illumination crosslinking double bond, by containing can macromonomer and antibacterials and the initiator of illumination crosslinking double bond
Mixing, prepares glucosan base transparent aquagel through light-initiated, by binding agent by described glucosan base transparent aquagel and load
Bluk recombination, makes glucosan base transparent aquagel dressing.
Preferably, described amidized little molecule is containing ethylene glycol fragment and activity while a kind of amino functional
The small molecule monomer of double bond.
It is highly preferred that described amidized little molecule be amino functional containing ethylene glycol fragment and carbon-carbon double bond
Small molecule monomer.
It is highly preferred that the preparation method of described amidized little molecule includes: Bis(tert-butoxycarbonyl)oxide is dissolved in dichloro
In methane, join and dissolved 1,8-diaminourea-3, the dichloromethane solution of 6 dioxaoctane reacts, removes dichloro
Methane, washing, it is extracted with ethyl acetate, organic layer is dried, together join in dichloromethane with methacrylic acid, then add
Entering 1-(3-dimethylamino-propyl)-3-ethyl-carbodiimide hydrochloride and I-hydroxybenzotriazole reacts, washing, by organic
Layer is dried, is dissolved in ethyl acetate, is passed through hydrogen chloride gas, has solid precipitation to separate out in solution, removes ethyl acetate, obtains ammonia
The little molecule of base.
Preferably, described glucosan quaternary ammonium salt derivative is by 2, and 3-epoxypropyltrimethylchloride chloride open loop is grafted
Obtain on glucosan.
It is highly preferred that the preparation method of described glucosan quaternary ammonium salt derivative includes: under the protection of nitrogen, Portugal is gathered
Sugar is dissolved in DMSO, adds DMAP, adds 2 after fully dissolving, and 3-epoxypropyltrimethylchloride chloride enters
Row reaction, adds hydrochloric acid and terminates reaction, and product isopropanol precipitating separates out, and filters, and is dried, and obtains glucosan quaternary ammonium salt and derives
Thing.
Preferably, described antibacterials are extensive pedigree antibiotic.
It is highly preferred that described antibacterials are levofloxacin.
Preferably, described glucosan base transparent aquagel has different degree of substitution.
Preferably, the intensity of described glucosan base transparent aquagel is by controlling the replacement of glucosan base transparent aquagel
Degree controls.
Preferably, the concrete steps of described " being reacted with succinic anhydride by glucosan quaternary ammonium salt derivative " including: 90
At DEG C, being dissolved in the mixed solution of LiCl and DMF by glucosan quaternary ammonium salt derivative, after being completely dissolved, solution is cooled to 60 DEG C,
It is subsequently adding triethylamine, stirring, add succinic anhydride, 60 DEG C of reaction 20h, products therefrom isopropyl precipitate with ethanol under the protection of nitrogen
Precipitation goes out, and filters, and is dried.
Preferably, the concrete steps of described " being reacted with amidized little molecule by products therefrom " including: is produced by gained
Thing is put in DMSO, be heated to 60 DEG C until being completely dissolved, cool to room temperature, add amidized little molecule, 1-(3-diformazan ammonia
Base propyl group)-3-ethyl-carbodiimide hydrochloride and I-hydroxybenzotriazole react, then analysed by product isopropanol precipitating
Go out, filter, be dried, obtain containing can illumination cross-link double bond macromonomer.
Preferably, described initiator is Ammonium persulfate..
Compared with existing aerogel dressing, the invention has the beneficial effects as follows:
(1) macromonomer of the present invention is glucosan, and glucosan biocompatibility is good, and it can activate in addition
Basal cell in immune system---macrophage, macrophage produces epidermal growth factor (EGF), thus promotes that wound is more
Close necessary collagen protein to produce, improve the regeneration capacity of damaged skin cell.Also have significant antiinflammatory, antiallergic is lived
Property, and can help to skin and resist ectogenic various mechanically and chemically stimulate.
(2) present invention uses chemical graft and two kinds of methods of pre-medicine carrying, and described glucosan quaternary ammonium salt derivative is to pass through
2,3-epoxypropyltrimethylchloride chloride open loops are grafted on glucosan obtain, thus have long-term antibacterial, and are loaded into water-setting
Levofloxacin within glue has sustained-release antibacterial effect, reaches dual antibacterial effect, is adopted by the anti-bacterial hydrogel dressing of preparation
By antibacterial standard GB/T20944.1-2007 agar plate diffusion method to Gram-positive S staphylococcus (S.aureus)
Carrying out antibacterial contrast test with Gram-E. coli (E.coli), antibacterial processed aerogel dressing can long-acting kill
Dead antibacterial.
(3) there is multiple hydroxyl on glucosan quaternary ammonium salt derivative, by reacting with succinic anhydride different mol ratio, obtain not
Macromonomer with substitution value.The present invention obtains the hydrogel of multiple intensity by multiple substitution value, is suitable for different times not
The demand of co-located wound in various degree, adds the multiformity of dressing.
(4) present invention has good anti-protein adsorption.Research worker research glucosan outside Jing, two temper polymer
And the macromolecular material such as PEG can suppress the absorption of protein and organism effectively.Therefore, what the present invention used gathers with Portugal
Sugar is substrate, by grafting quaternary ammonium salt and the small molecule monomer containing ethylene glycol fragment so that dressing in use can press down effectively
Protein processed and the absorption of organism also alleviate the secondary damage caused when replacing dressing due to adhesion.
(5) present invention is combined with each other with polyurethane film by hydrogel, the complementary deficiency of both sides, enhances dressing
Intensity and water absorbing and retaining properties, taken into account its good aqueous vapor permeability, the advantage inheriting again above-mentioned hydrogel, be made for more
For excellent dressing.
(6) product of gained of the present invention not only can absorb a large amount of wound fluid, keeps wound surface moistening, again can adhesion
Wound, reduces wound infection chance, wound healing.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of small molecule monomer synthesis；
Fig. 2 is the schematic diagram of hydrogel synthesis；
Fig. 3 is the structure chart of the composite aquogel dressing of embodiment 1 preparation.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is expanded on further.Should be understood that these embodiments are merely to illustrate the present invention
Rather than restriction the scope of the present invention.In addition, it is to be understood that after having read the content that the present invention lectures, people in the art
The present invention can be made various changes or modifications by member, and these equivalent form of values fall within the application appended claims equally and limited
Scope.
Embodiment 1
As it is shown on figure 3, a kind of glucosan base transparent aquagel dressing, including polyurethane film 1 and be located at thin polyurethane
Glucosan base transparent aquagel 2 on film 1, containing antibacterials in described glucosan base transparent aquagel 2.
The preparation method of above-mentioned glucosan base transparent aquagel dressing is:
A) amino functional containing ethylene glycol fragment and the preparation of the small molecule monomer of carbon-carbon double bond:
As it is shown in figure 1, Bis(tert-butoxycarbonyl)oxide (2g, 0.00918mol, structural formula is Fig. 1 Chinese style (2)) is dissolved in dichloro
In methane (50ml), being then added dropwise to dissolve 1,8-diaminourea-3, (8.151g, 0.055mol tie 6 dioxaoctane
Structure formula is Fig. 1 Chinese style (1)) dichloromethane (50ml) solution in, in 0 DEG C react 24 hours, remove dichloro with Rotary Evaporators
Methane, then washes with saturated aqueous common salt, then is extracted with ethyl acetate three times, merge organic layer, and being dried to obtain structural formula is Fig. 1
The product of Chinese style (3).
By product (1g, 0.0040mol) that structural formula is Fig. 1 Chinese style (3), (structural formula is Fig. 1 Chinese style with methacrylic acid
(4), during) (0.3442g, 0.0040mol) joins 100ml dichloromethane, the 1-(3-of (0.7668g, 0.0040mol) is added
Dimethylamino-propyl) I-hydroxybenzotriazole of-3-ethyl-carbodiimide hydrochloride and (0.5405g, 0.0040mol), 0
DEG C reaction 10 hours.Respectively with the hydrochloric acid solution (50mlx3) that concentration is 5%, concentration is the sodium bicarbonate solution (50ml) of 5%,
Deionized water (50ml) and saturated aqueous common salt (50ml) washing, be dried to obtain the product that structural formula is Fig. 1 Chinese style (5) by organic layer
Thing.
The product that structural formula is Fig. 1 Chinese style (5) is dissolved in 10ml ethyl acetate, is passed through hydrogen chloride gas 1.5h continuously, molten
Liquid there is solid precipitation separate out, with Rotary Evaporators, ethyl acetate is removed, obtain the amination that structural formula is Fig. 1 Chinese style (6)
Little molecule.
B) preparation of glucosan base macromonomer:
By 2,3-epoxypropyltrimethylchloride chloride open loop is grafted on glucosan obtain glucosan quaternary ammonium salt derivative: as
Shown in Fig. 2, under the protection of nitrogen, glucosan (5g, molecular weight is 20000, and structural formula is Fig. 2 Chinese style (7)) is dissolved in DMSO
In 45ml, add DMAP 1g, after fully dissolving, add 2,3-epoxypropyltrimethylchloride chloride 4.68g (knot
Structure formula is Fig. 2 Chinese style (8)), at normal temperatures after reaction 48h, add and terminate instead with the equimolar hydrochloric acid of DMAP
Should, product with isopropanol precipitating separate out, filter, then will filter after product put in vacuum drying oven be dried, obtain structural formula
Glucosan quaternary ammonium salt derivative for Fig. 2 Chinese style (9).
Glucosan quaternary ammonium salt derivative is reacted with succinic anhydride: at 90 DEG C, by molten for glucosan quaternary ammonium salt derivative 2g
In the mixed solution of LiCl and DMF (content of LiCl is 10%wt), after complete dissolution, solution is cooled to 60 DEG C, then
Adding triethylamine (0.1053g), succinic anhydride (1.04g), after 60 DEG C of stirrings 15 minutes, is joined in solution by solution.This is anti-
Should under the protection of nitrogen 60 DEG C reaction 20h.Product with isopropanol precipitating separate out, filter, then will filter after product put into very
Empty drying baker is dried, obtains the product that structural formula is Fig. 2 Chinese style (10).
Products therefrom is reacted with amidized little molecule: the product (2g) that structural formula is Fig. 2 Chinese style (10) is put into
In DMSO, be heated to 60 DEG C until being completely dissolved and cooling to room temperature again, add structural formula be the amidized little of Fig. 1 Chinese style (6)
Molecule (1.479g), 1-(3-dimethylamino-propyl)-3-ethyl-carbodiimide hydrochloride (1.325g) and I-hydroxybenzotriazole
(0.935g), react 10h at normal temperatures, then product isopropanol precipitating is separated out, filter, then the product after filtering is put into very
Empty drying baker is dried, obtain structural formula be Fig. 2 Chinese style (11) containing can the macromonomer of illumination crosslinking double bond.
C) preparation of glucosan based aquagel
By above-mentioned containing can illumination crosslinking double bond macromonomer weigh 0.1g, distilled water 20ml, initiator persulfuric acid
Ammonium 20mg, levofloxacin 0.2mg, uniformly mix, and carries out light-initiated double bond through uviol lamp and is cross-linked to form glucosan base transparent water
Gel；
D) preparation of combine dressing:
By the adhesive of medical (production company: Ethicon LLC, model: AHV12) with trade name DERMABOND
Described glucosan base transparent aquagel is combined with commercially available medical polyurethane film, makes glucosan base transparent aquagel and apply
Material.
Prepared aerogel dressing after 48h, reach swelling equilibrium, swelling ratio is 1005%, and its modulus of compressibility is
264kPa, uses antibacterial standard GB/T20944.1-2007 agar plate diffusion method to (Gram-positive S staphylococcus
(S.aureus) and Gram-E. coli (E.coli)) carry out antibacterial contrast test, its maximum antibacterial radius is (5.2
± 0.2) mm and (5.5 ± 0.2) mm, antibacterial effect is up to 6 days, it was demonstrated that this dressing has good water absorption, intensity and anti-
Bacterium property.
Embodiment 2
As it is shown on figure 3, a kind of glucosan base transparent aquagel dressing, including polyurethane film 1 and be located at thin polyurethane
Glucosan base transparent aquagel 2 on film 1, containing antibacterials in described glucosan base transparent aquagel 2.
The preparation method of above-mentioned glucosan base transparent aquagel dressing is similar to embodiment 1, and difference is:
Described step b) is:
By 2,3-epoxypropyltrimethylchloride chloride open loop is grafted on glucosan obtain glucosan quaternary ammonium salt derivative: as
Shown in Fig. 2, under the protection of nitrogen, glucosan (5g, molecular weight is (20000), and structural formula is Fig. 2 Chinese style (7)) is dissolved in
In DMSO (45ml), add DMAP (1g), after fully dissolving, add 2,3-epoxypropyltrimethylchloride chloride
(4.68g, structural formula is Fig. 2 Chinese style (8)), at normal temperatures after reaction 48h, add and the equimolar salt of DMAP
Acid terminate reaction, product with isopropanol precipitating separate out, filter, then will filter after product put in vacuum drying oven be dried,
Obtain the glucosan quaternary ammonium salt derivative that structural formula is Fig. 2 Chinese style (9).
At 90 DEG C, glucosan quaternary ammonium salt derivative (2g) is dissolved in the mixed of LiCl and DMF (LiCl content is 10%wt)
Closing in solution, after complete dissolution, solution is cooled to 60 DEG C, is subsequently adding triethylamine (0.2106g), and solution stirs 15 in 60 DEG C
After minute, succinic anhydride (2.08g) is joined in solution.This reaction is 60 DEG C of reaction 20h under the protection of nitrogen.Product is with different
Propanol Precipitation, filter, then will filter after product put in vacuum drying oven be dried, obtaining structural formula is Fig. 2 Chinese style
(10) product.
The product (2g) that structure above is Fig. 2 Chinese style (10) being put in DMSO, being heated to 60 DEG C until being completely dissolved
Cooling to room temperature.Add amidized little molecule (2.958g), 1-(3-dimethylamino third that structural formula is Fig. 1 Chinese style (6)
Base)-3-ethyl-carbodiimide hydrochloride (2.650g) and I-hydroxybenzotriazole (1.870g), react 10h at normal temperatures, then will
Product isopropanol precipitating, filter, then will filter after product put in vacuum drying oven be dried, obtaining structural formula is in Fig. 2
Formula (11) containing can illumination crosslinking double bond macromonomer.
Prepared aerogel dressing after 48h, reach swelling equilibrium, swelling ratio is 892%, and its modulus of compressibility is
297kPa, uses antibacterial standard GB/T20944.1-2007 agar plate diffusion method to (Gram-positive S staphylococcus
(S.aureus) and Gram-E. coli (E.coli) carries out antibacterial contrast test, its maximum antibacterial radius is respectively
(4.4 ± 0.2) mm and (4.8 ± 0.2) mm, antibacterial effect is up to 8 days, it was demonstrated that this dressing has good water absorption, intensity
And antibiotic property.
Claims (10)
1. a glucosan base transparent aquagel dressing, it is characterised in that include carrier and the glucosan base being located on carrier
Transparent aquagel, containing antibacterials in described glucosan base transparent aquagel.
2. glucosan base transparent aquagel dressing as claimed in claim 1, it is characterised in that described carrier is polyurethane
Film.
3. the preparation method of the glucosan base transparent aquagel dressing described in claim 1 or 2, it is characterised in that including: by Portugal
Polysaccharide quaternary ammonium salt derivative reacts with succinic anhydride, then is reacted with amidized little molecule by products therefrom, obtains containing can light
According to crosslinking double bond macromonomer, by containing can illumination crosslinking double bond macromonomer mix with antibacterials and initiator
Close, prepare glucosan base transparent aquagel through light-initiated, by binding agent by described glucosan base transparent aquagel and carrier
Compound, make glucosan base transparent aquagel dressing.
4. the preparation method of glucosan base transparent aquagel dressing as claimed in claim 3, it is characterised in that described amino
The little molecule changed is containing ethylene glycol fragment and the small molecule monomer of activity double key while a kind of amino functional.
5. the preparation method of glucosan base transparent aquagel dressing as claimed in claim 3, it is characterised in that described Portugal gathers
Sugar quaternary ammonium salt derivative is by 2, and 3-epoxypropyltrimethylchloride chloride open loop is grafted on glucosan obtain.
6. the preparation method of glucosan base transparent aquagel dressing as claimed in claim 3, it is characterised in that described Portugal gathers
Glycosyl transparent aquagel has different degree of substitution.
7. the preparation method of glucosan base transparent aquagel dressing as claimed in claim 3, it is characterised in that described Portugal gathers
The intensity of glycosyl transparent aquagel controls by controlling the substitution value of glucosan base transparent aquagel.
8. the preparation method of glucosan base transparent aquagel dressing as claimed in claim 3, it is characterised in that described " will
Glucosan quaternary ammonium salt derivative reacts with succinic anhydride " concrete steps include: at 90 DEG C, by glucosan quaternary ammonium salt derivative
Being dissolved in the mixed solution of LiCl and DMF, after being completely dissolved, solution is cooled to 60 DEG C, is subsequently adding triethylamine, stirring, adds
Succinic anhydride, 60 DEG C of reaction 20h under the protection of nitrogen, products therefrom isopropanol precipitating separates out, and filters, and is dried.
9. the preparation method of glucosan base transparent aquagel dressing as claimed in claim 3, it is characterised in that described " will
Products therefrom reacts with amidized little molecule " concrete steps include: products therefrom is put in DMSO, be heated to 60 DEG C straight
To being completely dissolved, cool to room temperature, add amidized little molecule, 1-(3-dimethylamino-propyl)-3-ethyl carbodiimide salt
Hydrochlorate and I-hydroxybenzotriazole react, then are separated out by product isopropanol precipitating, filter, are dried, obtain containing can light
Macromonomer according to crosslinking double bond.
10. the preparation method of glucosan base transparent aquagel dressing as claimed in claim 3, it is characterised in that described draws
Sending out agent is Ammonium persulfate..
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106632949A (en) * | 2016-12-22 | 2017-05-10 | 暨南大学 | Oligochitosan or derivative-modified polyurethane fiber dressing and preparation method thereof |
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| CN106632949B (en) * | 2016-12-22 | 2019-03-22 | 暨南大学 | The polyurethane fiber dressing and preparation method of a kind of chitosan oligosaccharide or derivatives thereof modification |
| CN106632949A (en) * | 2016-12-22 | 2017-05-10 | 暨南大学 | Oligochitosan or derivative-modified polyurethane fiber dressing and preparation method thereof |
| CN107261201B (en) * | 2017-07-03 | 2020-04-24 | 西南大学 | Agarose antibacterial dressing based on macromolecule quaternary ammonium salt grafting and preparation method thereof |
| CN107261201A (en) * | 2017-07-03 | 2017-10-20 | 西南大学 | A kind of agarose antiseptic dressing being grafted based on macromolecular quaternary ammonium salt and preparation method thereof |
| CN107353398A (en) * | 2017-08-07 | 2017-11-17 | 南方医科大学南方医院 | A kind of water-soluble unsaturated aliphatic polyester and its preparation method and application |
| CN108310452A (en) * | 2018-04-11 | 2018-07-24 | 南京工业大学 | A kind of Thermo-sensitive glucan based aquagel and preparation method thereof |
| CN108310452B (en) * | 2018-04-11 | 2021-05-04 | 南京工业大学 | Temperature-sensitive glucan-based hydrogel and preparation method thereof |
| CN108498853A (en) * | 2018-04-25 | 2018-09-07 | 重庆工程职业技术学院 | A kind of preparation method of polysaccharide quaternary ammonium salt antiseptic dressing |
| CN109157669B (en) * | 2018-09-18 | 2021-02-23 | 东华大学 | Cellulose-reinforced glucan-based injectable antibacterial hydrogel dressing and preparation method thereof |
| CN109157669A (en) * | 2018-09-18 | 2019-01-08 | 东华大学 | Cellulose enhances glucan base injectable anti-bacterial hydrogel dressing and preparation method thereof |
| CN110306193A (en) * | 2019-07-22 | 2019-10-08 | 陕西科技大学 | New type water-solubility Imidazoline Quatemary-ammonium-salt Corrosion Inhibitor and preparation method thereof |
| CN110511405A (en) * | 2019-10-11 | 2019-11-29 | 四川大学 | A kind of antimicrobial form keratin based aquagel and preparation method thereof |
| CN110511405B (en) * | 2019-10-11 | 2021-07-02 | 四川大学 | Antibacterial keratin-based hydrogel and preparation method thereof |
| CN111388748A (en) * | 2020-03-03 | 2020-07-10 | 东华大学 | Antibacterial and hemostatic multifunctional composite hydrogel dressing and preparation method thereof |
| CN111388741A (en) * | 2020-04-01 | 2020-07-10 | 东华大学 | Injectable self-repairing antibacterial hydrogel dressing preloaded with polypeptide and preparation method thereof |
| CN111388741B (en) * | 2020-04-01 | 2021-09-07 | 东华大学 | Injectable self-repairing antibacterial hydrogel dressing preloaded with polypeptide and preparation method thereof |
| CN115920112A (en) * | 2022-12-02 | 2023-04-07 | 深圳市菩安科技有限公司 | Long-acting antibacterial glucan-based transparent hydrogel dressing and preparation method thereof |
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