CN106039382B - A kind of glucan base transparent aquagel dressing and preparation method thereof - Google Patents
A kind of glucan base transparent aquagel dressing and preparation method thereof Download PDFInfo
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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Abstract
The present invention provides a kind of glucan base transparent aquagel dressing and preparation method thereof.The preparation method of the glucan base transparent aquagel dressing includes: to react glucan quaternary ammonium salt derivative with succinic anhydride, again by products therefrom and amidized small molecule reaction, obtain containing can illumination crosslinking double bond macromonomer, by containing can illumination crosslinking double bond macromonomer mixed with antibacterials and initiator, glucan base transparent aquagel is prepared through light-initiated, it is by adhesive that the glucan base transparent aquagel is compound with polyurethane film, glucan base transparent aquagel dressing is made.Resulting product of the present invention can not only absorb a large amount of wound fluids, keep surface of a wound wetting, and energy adhesion wound, reduce wound infection chance, wound healing.
Description
Technical field
The invention belongs to fabrics for industrial use technical fields, multiple more particularly to a kind of novel glucan base transparent aquagel
Close dressing.
Background technique
The it is proposed and confirmation of Winter moisture treatment theory in 1962 indicate the beginning of " moist dressing " revolution, from that with
Many scholars are directed to many disadvantages of gauze dressing afterwards, and long-term research has been carried out to dressing, it is desirable to research and develop treatment effect
The better dressing of fruit.Film dressing can prevent bacterium infection, provide gas exchanges, have many advantages, such as good mechanical performance,
But its moisture-vapor transmission is too small, and water absorbing properties are not good enough, easily causes sepage under film to gather, may induce or aggravate sense
Dye, so being only suitable for the less wound of diffusate.Foam-like dressing absorbability is good, and water vapo(u)r transmission is good, but the surface of a wound
Granulation tissue is easily grown into, and it is difficult to cause demoulding, and vulnerable to germ contamination.
Aerogel dressing is a kind of moist dressing, it has the advantage that it is soft, elasticity is good, can absorb a large amount of wounds infiltrations
Liquid out keeps surface of a wound wetting, and not will cause the hydrops between dressing and the surface of a wound；Tissue dewatering and Apoptosis are prevented, is accelerated
Vascularization；The protection surface of a wound resists penetrating for extraneous bacterium, reduces wound infection chance；Air-and water-permeable, oxygen, moisture can pass through
Gel reaches wound, keeps, promotes granulation and epithelial tissue normal growth, wound healing, preventing from scar；Aerogel dressing
Aquation repeatedly can occur when contacting with tissue, the moisture absorption in tissue into dressing, can the continuous absorption surface of a wound infiltration
Object out absorbs the hydrogel of exudate not contaminated wound, it is possible to need not more change dressings in about 3-7 days, hence it is evident that subtract
The number of dressing is lacked.In addition, aerogel dressing can be designed to transparence, doctor can observe wound change at any time through gel
Change situation, adjusts dosage in time.The requirement of the close ideal dressing of its feature of aerogel dressing, so being applied both at home and abroad to hydrogel
The research of material is in the ascendant.
Summary of the invention
The object of the present invention is to provide the transparent aquagel dressing of a kind of biocompatibility and product having enhanced antibacterial action, can absorb
A large amount of wound fluids keep surface of a wound wetting, and energy adhesion wound, reduce wound infection chance, wound healing.
In order to achieve the above object, the present invention provides a kind of glucan base transparent aquagel dressing, which is characterized in that
Glucan base transparent aquagel including carrier and on carrier contains antibacterial in the glucan base transparent aquagel
Drug.
Preferably, the carrier is polyurethane film.
The present invention also provides the preparation methods of above-mentioned glucan base transparent aquagel dressing characterized by comprising
Glucan quaternary ammonium salt derivative is reacted with succinic anhydride, then by products therefrom and amidized small molecule reaction, is contained
Can illumination crosslinking double bond macromonomer, by containing can illumination crosslinking double bond macromonomer and antibacterials and initiator
Mixing, prepares glucan base transparent aquagel through light-initiated, by the glucan base transparent aquagel and is carried by adhesive
Glucan base transparent aquagel dressing is made in bluk recombination.
Preferably, contain ethylene glycol segment and activity while the amidized small molecule is a kind of amino functional
The small molecule monomer of double bond.
It is highly preferred that the amidized small molecule is amino functional containing ethylene glycol segment and carbon-carbon double bond
Small molecule monomer.
It is highly preferred that the preparation method of the amidized small molecule includes: that di-tert-butyl dicarbonate is dissolved in dichloro
It in methane, is added in the dichloromethane solution for having dissolved 1,8- diamino -3,6 dioxaoctane and is reacted, remove dichloro
Methane, washing, is extracted with ethyl acetate, after organic layer drying, the adding into dichloromethane together with methacrylic acid, then plus
Enter 1- (3- dimethylamino-propyl) -3- ethyl-carbodiimide hydrochloride and I-hydroxybenzotriazole is reacted, washs, it will be organic
After layer is dry, it is dissolved in ethyl acetate, is passed through hydrogen chloride gas, there is solid Precipitation in solution, removed ethyl acetate, obtain ammonia
The small molecule of base.
Preferably, the glucan quaternary ammonium salt derivative is grafted by 2,3- epoxypropyltrimethylchloride chloride open loop
It is obtained on to glucan.
It is highly preferred that the preparation method of the glucan quaternary ammonium salt derivative includes: to gather Portugal under the protection of nitrogen
Sugar is dissolved in DMSO, be added 4-dimethylaminopyridine, to be added after completely dissolution 2,3- epoxypropyltrimethylchloride chloride into
Row reaction, hydrochloric acid is added, and reaction was completed, and product is precipitated with isopropanol precipitating, filters, dry, and it is derivative to obtain glucan quaternary ammonium salt
Object.
Preferably, the antibacterials are extensive pedigree antibiotic.
It is highly preferred that the antibacterials are lavo-ofloxacin.
Preferably, the glucan base transparent aquagel has different degree of substitution.
Preferably, the substitution that the intensity of the glucan base transparent aquagel passes through control glucan base transparent aquagel
Degree is to control.
Preferably, the specific steps of described " reacting glucan quaternary ammonium salt derivative with succinic anhydride " include: 90
At DEG C, glucan quaternary ammonium salt derivative is dissolved in the mixed solution of LiCl and DMF, after being completely dissolved, solution is cooled to 60 DEG C,
Then triethylamine is added, stirs, succinic anhydride, 60 DEG C of reaction 20h, products therefrom isopropyl alcohol precipitation under the protection of nitrogen is added
Precipitation goes out, and filters, dry.
Preferably, the specific steps of " by products therefrom and amidized small molecule reaction " include: to produce gained
Object is put into DMSO, is heated to 60 DEG C up to being completely dissolved, is cooled to room temperature, amidized small molecule, 1- (3- diformazan ammonia is added
Base propyl) -3- ethyl-carbodiimide hydrochloride and I-hydroxybenzotriazole are reacted, then product is analysed with isopropanol precipitating
Out, filter, it is dry, obtain containing can illumination be crosslinked the macromonomer of double bond.
Preferably, the initiator is ammonium persulfate.
Compared with existing aerogel dressing, the beneficial effects of the present invention are:
(1) macromonomer of the present invention is glucan, and glucan biocompatibility is good, and furthermore it can be activated
Basal cell in immune system --- macrophage, macrophage generates epidermal growth factor (EGF), so that wound be promoted to be cured
Collagen necessary to closing generates, and improves the power of regeneration of damaged skin cell.Also have significant anti-inflammatory, antiallergy living
Property, and can help to skin and resist exogenous various mechanically and chemically stimulate.
(2) present invention uses two methods of chemical graft and preloading medicine, and the glucan quaternary ammonium salt derivative is to pass through
2,3- epoxypropyltrimethylchloride chloride open loops, which are grafted on glucan, to be obtained, to have long-term antibacterial, and is loaded into water-setting
Lavo-ofloxacin inside glue has sustained-release antibacterial effect, reaches dual antibacterial effect, the anti-bacterial hydrogel dressing of preparation is adopted
With antibacterial standard GB/T20944.1-2007 agar plate diffusion method to Gram-positive S staphylococcus (S.aureus)
Antibacterial contrast test is carried out with Gram-E. coli (E.coli), antibacterial processed aerogel dressing long-acting can kill
Dead bacterium.
(3) there are multiple hydroxyls on glucan quaternary ammonium salt derivative, by being reacted with succinic anhydride different mol ratio, obtain not
With the macromonomer of degree of substitution.The present invention obtains the hydrogel of a variety of intensity by a variety of degree of substitution, is suitable for different times not
With the demand of the different degrees of wound in position, the diversity of dressing is increased.
(4) present invention has good anti-protein adsorption.Researcher outside studies glucan, two temper polymer
And the high molecular materials such as PEG can effectively inhibit the absorption of protein and organism.Therefore, what the present invention used is poly- with Portugal
Sugar is matrix, by being grafted the small molecule monomer of quaternary ammonium salt and the segment containing ethylene glycol, so that dressing can effectively press down in use
The absorption of protein processed and organism simultaneously mitigates the secondary damage as caused by adhesion when replacing dressing.
(5) present invention is combined with each other by hydrogel and polyurethane film, and the complementation deficiency of both sides enhances dressing
Intensity and water absorbing and retaining properties be made more the advantages of having taken into account its good aqueous vapor permeability, and inherited above-mentioned hydrogel
For excellent dressing.
(6) resulting product of the present invention can not only absorb a large amount of wound fluids, keep surface of a wound wetting, and can adhesion
Wound reduces wound infection chance, wound healing.
Detailed description of the invention
Fig. 1 is the schematic diagram of small molecule monomer synthesis；
Fig. 2 is the schematic diagram that water-setting composes；
Fig. 3 is the structure chart of composite hydrogel dressing prepared by embodiment 1.
Specific embodiment
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, those skilled in the art
Member can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Range.
Embodiment 1
As shown in figure 3, a kind of glucan base transparent aquagel dressing, including polyurethane film 1 and it is set to thin polyurethane
Glucan base transparent aquagel 2 on film 1 contains antibacterials in the glucan base transparent aquagel 2.
Above-mentioned glucan base transparent aquagel dressing the preparation method comprises the following steps:
A) preparation of the small molecule monomer containing ethylene glycol segment and carbon-carbon double bond of amino functional:
As shown in Figure 1, di-tert-butyl dicarbonate (2g, 0.00918mol, structural formula are Fig. 1 Chinese style (2)) is dissolved in dichloro
In methane (50ml), then it is added dropwise to and has dissolved 1,8- diamino -3,6 dioxaoctane (8.151g, 0.055mol, knot
Structure formula be Fig. 1 Chinese style (1)) methylene chloride (50ml) solution in, in 0 DEG C react 24 hours, remove dichloro with Rotary Evaporators
Then methane is washed with saturated salt solution, then be extracted with ethyl acetate three times, merges organic layer, and being dried to obtain structural formula is Fig. 1
The product of Chinese style (3).
By product (1g, 0.0040mol) that structural formula is Fig. 1 Chinese style (3), (structural formula is Fig. 1 Chinese style with methacrylic acid
(4)) (0.3442g, 0.0040mol) is added in 100ml methylene chloride, adds the 1- (3- of (0.7668g, 0.0040mol)
Dimethylamino-propyl) -3- ethyl-carbodiimide hydrochloride and (0.5405g, 0.0040mol) I-hydroxybenzotriazole, 0
DEG C reaction 10 hours.The hydrochloric acid solution (50mlx3) for being respectively 5% with concentration, the sodium bicarbonate solution (50ml) that concentration is 5%,
Organic layer is dried to obtain the production that structural formula is Fig. 1 Chinese style (5) by deionized water (50ml) and saturated salt solution (50ml) washing
Object.
The product that structural formula is Fig. 1 Chinese style (5) is dissolved in 10ml ethyl acetate, is continuously passed through hydrogen chloride gas 1.5h, it is molten
There is solid Precipitation in liquid, removed ethyl acetate with Rotary Evaporators, obtains the amination that structural formula is Fig. 1 Chinese style (6)
Small molecule.
B) preparation of glucan base macromonomer:
2,3- epoxypropyltrimethylchloride chloride open loop is grafted on glucan and obtains glucan quaternary ammonium salt derivative: such as
Shown in Fig. 2, glucan (5g, molecular weight 20000, structural formula are Fig. 2 Chinese style (7)) is dissolved in DMSO under the protection of nitrogen
In 45ml, 4-dimethylaminopyridine 1g is added, to which 2,3- epoxypropyltrimethylchloride chloride 4.68g (knot after completely dissolution, is added
Structure formula is Fig. 2 Chinese style (8)), after reacting 48h at normal temperature, being added with the equimolar hydrochloric acid of 4-dimethylaminopyridine terminates instead
It answers, product is precipitated with isopropanol precipitating, filtering, then filtered product is put into drying in vacuum oven, obtains structural formula
For the glucan quaternary ammonium salt derivative of Fig. 2 Chinese style (9).
Glucan quaternary ammonium salt derivative is reacted with succinic anhydride: at 90 DEG C, glucan quaternary ammonium salt derivative 2g is molten
In the mixed solution of LiCl and DMF (content of LiCl is 10%wt), after complete dissolution, solution is cooled to 60 DEG C, then
It is added triethylamine (0.1053g), succinic anhydride (1.04g) is added in solution by solution after 60 DEG C are stirred 15 minutes.This is anti-
Should under the protection of nitrogen 60 DEG C of reaction 20h.Product is precipitated with isopropanol precipitating, filtering, then filtered product is put into very
It is dry in empty drying box, obtain the product that structural formula is Fig. 2 Chinese style (10).
By products therefrom and amidized small molecule reaction: the product (2g) that structural formula is Fig. 2 Chinese style (10) is put into
It in DMSO, is heated to 60 DEG C and cools to room temperature again until being completely dissolved, it is the amidized small of Fig. 1 Chinese style (6) that structural formula, which is added,
Molecule (1.479g), 1- (3- dimethylamino-propyl) -3- ethyl-carbodiimide hydrochloride (1.325g) and I-hydroxybenzotriazole
(0.935g) reacts 10h at normal temperature, then product is precipitated with isopropanol precipitating, filtering, then filtered product is put into very
It is dry in empty drying box, obtain structural formula be Fig. 2 Chinese style (11) containing can illumination be crosslinked the macromonomer of double bond.
C) preparation of glucan based aquagel
By it is above-mentioned containing can illumination crosslinking double bond macromonomer weigh 0.1g, distilled water 20ml, initiator persulfuric acid
Ammonium 20mg, lavo-ofloxacin 0.2mg are uniformly mixed, are carried out light-initiated double bond through ultraviolet lamp and be cross-linked to form glucan base transparent water
Gel；
D) preparation of combine dressing:
Pass through the adhesive of medical (production company: Ethicon LLC, model: AHV12) with trade name DERMABOND
The glucan base transparent aquagel and commercially available medical polyurethane film is compound, glucan base transparent aquagel is made and applies
Material.
Prepared aerogel dressing reaches swelling equilibrium after 48h, swelling ratio 1005%, and compression modulus is
264kPa, using antibacterial standard GB/T20944.1-2007 agar plate diffusion method to (Gram-positive S staphylococcus
(S.aureus) and Gram-E. coli (E.coli)) carry out antibacterial contrast test, maximum antibacterial radius is (5.2
± 0.2) mm and (5.5 ± 0.2) mm, antibacterial effect be up to 6 days, it was demonstrated that the dressing has good water imbibition, intensity and anti-
Bacterium property.
Embodiment 2
As shown in figure 3, a kind of glucan base transparent aquagel dressing, including polyurethane film 1 and it is set to thin polyurethane
Glucan base transparent aquagel 2 on film 1 contains antibacterials in the glucan base transparent aquagel 2.
The preparation method of above-mentioned glucan base transparent aquagel dressing is similar to embodiment 1, and difference is:
The step b) are as follows:
2,3- epoxypropyltrimethylchloride chloride open loop is grafted on glucan and obtains glucan quaternary ammonium salt derivative: such as
Shown in Fig. 2, glucan (5g, molecular weight are (20000), and structural formula is Fig. 2 Chinese style (7)) is dissolved under the protection of nitrogen
It in DMSO (45ml), is added 4-dimethylaminopyridine (1g), to after completely dissolution, 2,3- epoxypropyltrimethylchloride chloride be added
(4.68g, structural formula is Fig. 2 Chinese style (8)), after reacting 48h at normal temperature, it is added and the equimolar salt of 4-dimethylaminopyridine
Acid is next, and reaction was completed, and product is precipitated with isopropanol precipitating, filtering, then filtered product is put into drying in vacuum oven,
Obtain the glucan quaternary ammonium salt derivative that structural formula is Fig. 2 Chinese style (9).
At 90 DEG C, glucan quaternary ammonium salt derivative (2g) is dissolved in the mixed of LiCl and DMF (LiCl content is 10%wt)
It closes in solution, after complete dissolution, solution is cooled to 60 DEG C, and triethylamine (0.2106g) then is added, and solution stirs 15 in 60 DEG C
After minute, succinic anhydride (2.08g) is added in solution.The reaction 60 DEG C of reaction 20h under the protection of nitrogen.Product is with different
Propyl alcohol Precipitation, filtering, then filtered product is put into drying in vacuum oven, obtaining structural formula is Fig. 2 Chinese style
(10) product.
The product (2g) that structure above is Fig. 2 Chinese style (10) is put into DMSO, is heated to 60 DEG C until being completely dissolved
Cooling to room temperature.Adding structural formula is the amidized small molecule (2.958g) of Fig. 1 Chinese style (6), 1- (3- dimethylamino third
Base) -3- ethyl-carbodiimide hydrochloride (2.650g) and I-hydroxybenzotriazole (1.870g), react 10h, then will at normal temperature
Product isopropanol precipitating, filtering, then filtered product is put into drying in vacuum oven, obtaining structural formula is in Fig. 2
Formula (11) containing can illumination crosslinking double bond macromonomer.
Prepared aerogel dressing reaches swelling equilibrium after 48h, swelling ratio 892%, and compression modulus is
297kPa, using antibacterial standard GB/T20944.1-2007 agar plate diffusion method to (Gram-positive S staphylococcus
(S.aureus) and Gram-E. coli (E.coli) carries out antibacterial contrast test, and maximum antibacterial radius is respectively
(4.4 ± 0.2) mm and (4.8 ± 0.2) mm, antibacterial effect be up to 8 days, it was demonstrated that the dressing has good water imbibition, intensity
And antibiotic property.
Claims (9)
1. a kind of preparation method of glucan base transparent aquagel dressing, the glucan base transparent aquagel dressing, including
Carrier and the glucan base transparent aquagel on carrier contain antimicrobial in the glucan base transparent aquagel
Object, which is characterized in that the preparation method includes: to react glucan quaternary ammonium salt derivative with succinic anhydride, then gained is produced
Object and amidized small molecule reaction, obtain containing can illumination crosslinking double bond macromonomer, will be containing can illumination crosslinking pair
The macromonomer of key is mixed with antibacterials and initiator, is prepared glucan base transparent aquagel through light-initiated, is passed through bonding
Agent is compound with carrier by the glucan base transparent aquagel, and glucan base transparent aquagel dressing is made.
2. the preparation method of glucan base transparent aquagel dressing as described in claim 1, which is characterized in that the carrier
For polyurethane film.
3. the preparation method of glucan base transparent aquagel dressing as described in claim 1, which is characterized in that the amino
Contain the small molecule monomer of ethylene glycol segment and activity double key while the small molecule of change is a kind of amino functional.
4. the preparation method of glucan base transparent aquagel dressing as described in claim 1, which is characterized in that the Portugal is poly-
Sugared quaternary ammonium salt derivative is to be grafted on glucan to obtain by 2,3- epoxypropyltrimethylchloride chloride open loop.
5. the preparation method of glucan base transparent aquagel dressing as described in claim 1, which is characterized in that the Portugal is poly-
Glycosyl transparent aquagel has different degree of substitution.
6. the preparation method of glucan base transparent aquagel dressing as described in claim 1, which is characterized in that the Portugal is poly-
The intensity of glycosyl transparent aquagel is controlled by controlling the degree of substitution of glucan base transparent aquagel.
7. the preparation method of glucan base transparent aquagel dressing as described in claim 1, which is characterized in that described " will
Glucan quaternary ammonium salt derivative is reacted with succinic anhydride " specific steps include: at 90 DEG C, by glucan quaternary ammonium salt derivative
It is dissolved in the mixed solution of LiCl and DMF, after being completely dissolved, solution is cooled to 60 DEG C, and triethylamine is then added, and stirs, and is added
Succinic anhydride, 60 DEG C of reaction 20h, products therefrom are precipitated with isopropanol precipitating under the protection of nitrogen, are filtered, dry.
8. the preparation method of glucan base transparent aquagel dressing as described in claim 1, which is characterized in that described " will
The specific steps of products therefrom and amidized small molecule reaction " include: that products therefrom is put into DMSO, are heated to 60 DEG C directly
To being completely dissolved, room temperature is cooled to, amidized small molecule, 1- (3- dimethylamino-propyl) -3- ethyl carbodiimide salt is added
Hydrochlorate and I-hydroxybenzotriazole are reacted, then product is precipitated with isopropanol precipitating, are filtered, dry, are obtained containing can light
According to the macromonomer of crosslinking double bond.
9. the preparation method of glucan base transparent aquagel dressing as described in claim 1, which is characterized in that the initiation
Agent is ammonium persulfate.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610352508.7A CN106039382B (en) | 2016-05-25 | 2016-05-25 | A kind of glucan base transparent aquagel dressing and preparation method thereof |
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| CN201610352508.7A CN106039382B (en) | 2016-05-25 | 2016-05-25 | A kind of glucan base transparent aquagel dressing and preparation method thereof |
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| CN106039382A CN106039382A (en) | 2016-10-26 |
| CN106039382B true CN106039382B (en) | 2019-06-04 |
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| CN106632949B (en) * | 2016-12-22 | 2019-03-22 | 暨南大学 | The polyurethane fiber dressing and preparation method of a kind of chitosan oligosaccharide or derivatives thereof modification |
| CN107261201B (en) * | 2017-07-03 | 2020-04-24 | 西南大学 | Agarose antibacterial dressing based on macromolecule quaternary ammonium salt grafting and preparation method thereof |
| CN107353398B (en) * | 2017-08-07 | 2019-02-15 | 南方医科大学南方医院 | A kind of water solubility unsaturated aliphatic polyester and its preparation method and application |
| CN108310452B (en) * | 2018-04-11 | 2021-05-04 | 南京工业大学 | Temperature-sensitive glucan-based hydrogel and preparation method thereof |
| CN108498853A (en) * | 2018-04-25 | 2018-09-07 | 重庆工程职业技术学院 | A kind of preparation method of polysaccharide quaternary ammonium salt antiseptic dressing |
| CN109157669B (en) * | 2018-09-18 | 2021-02-23 | 东华大学 | Cellulose-reinforced glucan-based injectable antibacterial hydrogel dressing and preparation method thereof |
| CN110306193A (en) * | 2019-07-22 | 2019-10-08 | 陕西科技大学 | New type water-solubility Imidazoline Quatemary-ammonium-salt Corrosion Inhibitor and preparation method thereof |
| CN110511405B (en) * | 2019-10-11 | 2021-07-02 | 四川大学 | Antibacterial keratin-based hydrogel and preparation method thereof |
| CN111388748B (en) * | 2020-03-03 | 2021-08-06 | 东华大学 | Antibacterial and hemostatic multifunctional composite hydrogel dressing and preparation method thereof |
| CN111388741B (en) * | 2020-04-01 | 2021-09-07 | 东华大学 | Injectable self-repairing antibacterial hydrogel dressing preloaded with polypeptide and preparation method thereof |
| CN115920112A (en) * | 2022-12-02 | 2023-04-07 | 深圳市菩安科技有限公司 | Long-acting antibacterial glucan-based transparent hydrogel dressing and preparation method thereof |
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| CN101664563B (en) * | 2009-09-21 | 2012-09-19 | 杭州国纳科技有限公司 | Preparation method of anti-bacterial hydrogel dressing |
| FR2955032B1 (en) * | 2010-01-14 | 2012-03-02 | Urgo Lab | NEW DRESSING COMPRISING PARTICULATE AGGLOMERATES CAPABLE OF GELIFIER OR RAPIDLY SOLUBULIZE |
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