CN106037983A - Fixing device for rat oral and nasal inhalation exposure experiment - Google Patents
Fixing device for rat oral and nasal inhalation exposure experiment Download PDFInfo
- Publication number
- CN106037983A CN106037983A CN201610542125.6A CN201610542125A CN106037983A CN 106037983 A CN106037983 A CN 106037983A CN 201610542125 A CN201610542125 A CN 201610542125A CN 106037983 A CN106037983 A CN 106037983A
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- rat
- fixator
- exposure
- experiment
- mouth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Husbandry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Catching Or Destruction (AREA)
Abstract
The invention relates to a fixing device for a rat oral and nasal inhalation exposure experiment, which comprises rat fixators, a multi-layered support (6) for the rat fixators, a supporting plate (9), an exposure chamber (7) and exposure chamber connecting openings (8), and is characterized in that the multi-layered support (6) is arranged on the supporting plate (9) and surrounds the exposure chamber (7); brackets (4) of the rat fixators are fixed to the corresponding positions of the multi-layered support (6); the front end of each rat fixator provided with a faeces and urine collector (3) is steadily connected with the corresponding exposure chamber connecting opening (8), the main body of the rat fixator is arranged on the correspondingly mounted bracket (4), and the rat fixator is firmly fixed by an elastic fixing belt (5) arranged on the bracket (4); and the rat fixators, the multi-layered support (6) for the rat fixators and the exposure chamber connecting openings (8) are in steady corporation. The fixing device can ensure that the rat fixators are firm and reliable in the experiment process, and even if experiment rats struggle, the condition that the rat fixators are loose cannot happen.
Description
Technical field
The present invention relates to experimental provision, particularly relate to a kind of rat mouth and nose and suck exposure fixing device for experiment.
Background technology
Existing mouth and nose suck exposure experimental rat holder major defect: rat fixator and the connection of exposure device
Place's fastness is poor, and rat is easily caused holder and loosens or come off when struggling；Rat fixator front end and exposure device coupling part
Longer, cause the mouth and nose of rat to be difficult to contact tested material aerosol；The feces urine collector of rat fixator configuration, with fixing
Device is one, it is impossible to individually dismantle, and increases and cleans difficulty.
Summary of the invention
It is an object of the invention to provide one and can realize adjustable to rat is fixing, thus ensure that rat is in and can expose
The fixing device of environment, the feces urine that this fixing device is prevented from collecting simultaneously leaks outside, and is readily cleaned after use, protects
Confirm to test health.
The technical scheme is that a kind of rat mouth and nose of offer suck and expose fixing device for experiment, fix including rat
Device, the multilamellar fixed support of rat fixator, gripper shoe, exposure chamber and exposure chamber interface, it is characterised in that: multilamellar fixed support
It is placed in gripper shoe and around exposure chamber；The bracket of rat fixator is fixed on the relevant position on multilamellar fixed support；Will
The connection that the front end of the rat fixator being equipped with feces urine collector consolidates with exposed interface, and by rat fixator main body
It is placed on mounted bracket, with the elastic reducing-fixing band of configuration on bracket by rat fixator fixation；By rat from rat
The tail end opening part of holder puts into rat accommodation chamber, and from the tail end installation activity baffle plate of rat accommodation chamber, sideboard is to greatly
The front end of Mus accommodation chamber is moved, so that the mouth and nose of the rat in rat accommodation chamber stretch out the front end of rat accommodation chamber, with contact
Exposed environments, and by the tail of rat through the circular hole on sideboard.
The beneficial effects of the present invention is:
(1) rat fixator, rat support 6 and the secure fit of exposure chamber interface 8, it is ensured that in experimentation, rat is solid
Determine the solid and reliable of device, even if experiment white mouse occurs to struggle also does not results in the situation that rat fixator gets loose.
(2) elastic reducing-fixing band combines the advantage of VELCRO, can be tightly fixed to convenient for rat fixator on support 6,
Guaranteeing does not gets loose rocks.
(3) rat accommodation chamber transparent organic glass makes, and facilitates the state of rat in observation experiment.
(4) with the sideboard of adjustable position, it is adaptable to the rat of fixing different building shape, it is possible to prevent rat to retreat
Flee from exposed environments.
(5) rat fixator configures dismountable Large Copacity feces urine collector, and the feces urine of collection is difficult to leak outside,
It is readily cleaned after use, it is ensured that experiment health.
(6) support stainless steel makes, and structural rigidity is strong, overall can take out from toxicant exposure cabinet, facilitates inside device
Cleaning.
Accompanying drawing explanation
Fig. 1 is that rat mouth and nose suck exposure fixing device for experiment structural representation；
Fig. 2 is rat fixator decomposing schematic representation；
Fig. 3 is rat fixator schematic diagram；
Fig. 4 is rat fixator multilamellar fixed support schematic diagram；
Fig. 5 is the exposure chamber schematic diagram that rat mouth and nose suck exposing device.
Wherein: 1, rat accommodation chamber, 2, sideboard, 3, feces urine collector, 4, bracket, 5, elastic reducing-fixing band, 6,
Rat fixator multilamellar fixed support, 7, exposure chamber, 8, exposure chamber interface, 9, gripper shoe, 10, latch, 11, circular hole.
Detailed description of the invention
Below with reference to accompanying drawing 1-5, technical scheme is described in detail.
As it is shown in figure 1, rat mouth and nose suck the exposure fixing device for experiment of exposing device, including rat fixator, rat
Holder multilamellar fixed support 6, gripper shoe 9, exposure chamber 7 and exposure chamber interface 8, wherein: rat fixator multilamellar fixed support 6
It is placed in gripper shoe 9 and around exposure chamber 7；Bracket 4 is fixed on the relevant position on rat fixator multilamellar fixed support 6；
Will be equipped with front end and the firm connection of exposure chamber interface 8 of the rat fixator of feces urine collector 3, and rat is fixed
Device main body is placed in on mounted bracket 4, with the elastic reducing-fixing band 5 of configuration on bracket 4 by rat fixator fix tightly；Will be big
Mus puts into rat accommodation chamber 1 from the tail end opening part of rat fixator, installs fixing sideboard 2 and arrives appropriate location, makes rat
Mouth and nose stretch out the front end of rat accommodation chamber 1, to contact exposed environments, and by the tail of rat through the circle on sideboard 2
Hole 11.
Being a rat fixator schematic diagram shown in Fig. 2 and Fig. 3, it includes rat accommodation chamber 1, sideboard 2, feces urine
Catcher 3, bracket 4, elastic reducing-fixing band 5.Rat accommodation chamber 1 transparent organic glass makes, and its front end is and rat head phase
The tapered conical bucket adapted to；The main part of accommodation chamber is that drum fills cylinder, and the opening of different in width is all arranged at its top and bottom
Groove, open top groove is used for the movement of sideboard 2 and fixes, and the open slot of bottom is easy to the feces urine of rat excretion and is entered
The feces urine collector 3 being connected with receiving chamber, bottom is equipped with the latch 10 supporting with feces urine collector 3 upper groove, logical
Cross groove and latch 10 coordinates, facilitate installation and the disassembly, cleaning of feces urine collector 3；Sideboard 2 is by can the spiral shell of degree of tightness
Female and there is certain thickness circular baffle plate composition, have inside the circular baffle plate of its configuration the curved surface adapted with rat buttocks and
Can allow the circular hole 11 that rat tail passes.
Fig. 4 is rat fixator multilamellar fixed support schematic diagram, is made with rustless steel, subsidiary with it by bracket 4
Elastic reducing-fixing band 5 rat fixator shown in Fig. 1 can be fixed on rat fixator multilamellar fixed support 6；Rat is fixed
Device multilamellar fixed support 6 is followed successively by the base by stainless steel substrates material, lower floor, middle level and upper strata from top to bottom, logical between each layer
Crossing threaded rod and nut is fixed, every layer height adapts with the height of exposure chamber interface 8, in order to the most fixing rat is fixed
Device.
Fig. 5 show exposure chamber main body, and exposure chamber 7 is placed in gripper shoe 9, and it uses big volume, major diameter barrel-shaped
Structure, the sedimentation of dust is similar to the natural subsidence of particulate in air, the exposure chamber in simulation actual environment, and lower end connects
There are taper dust collection, exposure chamber interface 8 to take rational staggered arrangement, both can guarantee that experiment capacity, can prevent again mutually
Cover interference, advantageously ensure that the concordance of laboratory animal exposed environments.Interface is furnished with blind plate, can be with occluding member interface, side
Just the experiment of (laboratory animal quantity) more on a small scale is carried out.
The invention also discloses a kind of method utilizing this fixing device to carry out the suction exposure experiment of rat mouth and nose,
Step 1: rat fixator multilamellar fixed support 6 is placed in appropriate location in gripper shoe 9, is looped around exposure chamber 7 main
External, the bracket 4 that then will be equipped with elastic reducing-fixing band 5 is fixed on the appropriate location of rat fixator multilamellar fixed support 6；
Step 2: be placed on bracket 4 by the rat fixator combined, the front end of rat accommodation chamber 1 is fixed on exposure chamber and is connect
Mouth 8, strains elastic reducing-fixing band 5, makes firm being fixed on rat fixator multilamellar fixed support 6 of rat fixator；
Step 3: taken out by sideboard 2, puts into the head of rat in rat accommodation chamber 1, and now rat can climb voluntarily
Enter in cabin, by the tail of rat through the circular hole 11 on sideboard 2, fixing sideboard 2 is installed and arrives appropriate location, make rat
Mouth and nose stretch out the front end of rat accommodation chamber 1, to contact exposed environments.
Claims (5)
1. rat mouth and nose suck and expose a fixing device for experiment, including fixing of the multilamellar of rat fixator, rat fixator
Frame (6), gripper shoe (9) gripper shoe (9), exposure chamber (7) and exposure chamber interface (8), it is characterised in that: multilamellar fixed support (6)
It is placed in gripper shoe (9) upper also around exposure chamber (7)；The bracket (4) of rat fixator is fixed on multilamellar fixed support (6)
Relevant position；The company that the front end of the rat fixator that will be equipped with feces urine collector (3) consolidates with exposure chamber interface (8)
Connecing, and rat fixator main body be placed in on mounted bracket (4), the elastic reducing-fixing band (5) with the upper configuration of bracket (4) will
Rat fixator fix tightly；Rat is put into rat accommodation chamber (1) from the tail end opening part of rat fixator, from rat accommodation chamber
(1) tail end installation activity baffle plate (2), sideboard (2) can move to the front end of rat accommodation chamber, so that rat accommodates
The mouth and nose of the rat in cabin stretch out the front end of rat accommodation chamber (1), to contact exposed environments, and by the tail of rat through activity
Circular hole (11) on baffle plate (2).
Rat mouth and nose the most according to claim 1 suck and expose fixing device for experiment, and wherein, rat fixator includes rat
Accommodation chamber (1), sideboard (2), feces urine collector (3), bracket (4), elastic reducing-fixing band (5), it is characterised in that: rat
Accommodation chamber (1) transparent organic glass makes, and its front end is the tapered conical bucket adapted with rat head；Rat accommodation chamber
(1) main part is that drum fills cylinder, and the open slot of different in width is all arranged at its top and bottom, and open top groove is for activity
The movement of baffle plate (2) and fixing, the open slot of bottom is easy to the feces urine of rat excretion and is entered and be connected with rat accommodation chamber (1)
Feces urine collector (3), bottom is equipped with the latch (10) supporting with feces urine collector (3) upper groove, facilitates feces
The installation of urine collector (3) and disassembly, cleaning；Sideboard (2) is by can the nut of degree of tightness and have certain thickness circular gear
Plate forms, and has the curved surface adapted with rat buttocks and the circular hole that rat tail can be allowed to pass inside the circular baffle plate of its configuration
(11)。
Rat mouth and nose the most according to claim 1 suck and expose fixing device for experiment, it is characterised in that: rat fixator is many
Layer fixed support (6) is followed successively by the base by stainless steel substrates material, lower floor, middle level and upper strata from top to bottom, passes through between each layer
Threaded rod and nut are fixed, and every layer height adapts with the height of exposure chamber interface (8).
Rat mouth and nose the most according to claim 1 suck and expose fixing device for experiment, it is characterised in that: exposure chamber (7) is put
In gripper shoe (9), lower end connects has taper dust collection, exposure chamber interface (8) to take staggered arrangement, both can guarantee that experiment
Capacity, can prevent from again mutually covering interference, it is ensured that the concordance of laboratory animal exposed environments, and interface is furnished with blind plate, is used for blocking
Part of interface, conveniently carries out more small-scale exposure and tests..
5. utilize the rat mouth and nose suction exposure fixing device for experiment that utilizes described in claim 1 to carry out the suction exposure of rat mouth and nose
The method of experiment, it is characterised in that:
Step 1: rat fixator multilamellar fixed support (6) is placed in the upper appropriate location of gripper shoe (9), is looped around exposure chamber (7)
Outside main body, the bracket (4) that then will be equipped with elastic reducing-fixing band (5) is fixed on the suitable of rat fixator multilamellar fixed support (6)
Position；
Step 2: being placed in by the rat fixator combined on bracket (4), the front end of rat accommodation chamber (1) is fixed on exposure chamber and is connect
Mouth (8), tension elastic reducing-fixing band (5), make firm being fixed on rat fixator multilamellar fixed support (6) of rat fixator；
Step 3: taken out by sideboard (2), puts into rat accommodation chamber (1) inner by the head of rat, and now rat can climb voluntarily
Enter in cabin, by the tail of rat through the circular hole (11) on sideboard (2), fixing sideboard (2) be installed and arrive appropriate location,
The mouth and nose making rat stretch out the front end of rat accommodation chamber (1), to contact exposed environments.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610542125.6A CN106037983B (en) | 2016-07-11 | 2016-07-11 | A kind of rat mouth and nose suction exposure fixing device for experiment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610542125.6A CN106037983B (en) | 2016-07-11 | 2016-07-11 | A kind of rat mouth and nose suction exposure fixing device for experiment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106037983A true CN106037983A (en) | 2016-10-26 |
| CN106037983B CN106037983B (en) | 2017-12-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610542125.6A Active CN106037983B (en) | 2016-07-11 | 2016-07-11 | A kind of rat mouth and nose suction exposure fixing device for experiment |
Country Status (1)
| Country | Link |
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| CN (1) | CN106037983B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388133A (en) * | 2020-02-18 | 2020-07-10 | 山东中医药大学附属医院 | Experimental mouse fixing device that uses |
| CN112773549A (en) * | 2019-11-07 | 2021-05-11 | 中国人民解放军军事科学院军事医学研究院 | Positionable rodent immobilization device for electromagnetic radiation exposure |
| CN113856510A (en) * | 2021-10-12 | 2021-12-31 | 兵器工业卫生研究所 | Real-time mixed inhalation exposure device for multi-component gas of laboratory mouse |
| WO2024109897A1 (en) * | 2022-11-24 | 2024-05-30 | 中国科学院深圳先进技术研究院 | Oral/nasal inhalation exposure apparatus capable of observation and recording videos |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5320069A (en) * | 1992-04-28 | 1994-06-14 | The United States Of America As Represented By The Secretary Of The Army | Small animal restraint device |
| CN101999947A (en) * | 2009-09-03 | 2011-04-06 | 范维林 | Mouse mouth and nose exposed holder |
| CN102824227A (en) * | 2012-09-26 | 2012-12-19 | 天津开发区合普工贸有限公司 | Sitting canoidea animal oro-nasal respiration experimental equipment |
| CN203576687U (en) * | 2013-12-10 | 2014-05-07 | 天津开发区合普工贸有限公司 | Full sealed isolation small animal mouth and nose exposing frame |
| CN203677296U (en) * | 2013-11-15 | 2014-07-02 | 天津开发区合普工贸有限公司 | Small animal mouth and nose exposure flexible restraining frame |
-
2016
- 2016-07-11 CN CN201610542125.6A patent/CN106037983B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5320069A (en) * | 1992-04-28 | 1994-06-14 | The United States Of America As Represented By The Secretary Of The Army | Small animal restraint device |
| CN101999947A (en) * | 2009-09-03 | 2011-04-06 | 范维林 | Mouse mouth and nose exposed holder |
| CN102824227A (en) * | 2012-09-26 | 2012-12-19 | 天津开发区合普工贸有限公司 | Sitting canoidea animal oro-nasal respiration experimental equipment |
| CN203677296U (en) * | 2013-11-15 | 2014-07-02 | 天津开发区合普工贸有限公司 | Small animal mouth and nose exposure flexible restraining frame |
| CN203576687U (en) * | 2013-12-10 | 2014-05-07 | 天津开发区合普工贸有限公司 | Full sealed isolation small animal mouth and nose exposing frame |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112773549A (en) * | 2019-11-07 | 2021-05-11 | 中国人民解放军军事科学院军事医学研究院 | Positionable rodent immobilization device for electromagnetic radiation exposure |
| CN112773549B (en) * | 2019-11-07 | 2024-08-09 | 中国人民解放军军事科学院军事医学研究院 | Positionable rodent fixation device for electromagnetic radiation exposure |
| CN111388133A (en) * | 2020-02-18 | 2020-07-10 | 山东中医药大学附属医院 | Experimental mouse fixing device that uses |
| CN113856510A (en) * | 2021-10-12 | 2021-12-31 | 兵器工业卫生研究所 | Real-time mixed inhalation exposure device for multi-component gas of laboratory mouse |
| CN113856510B (en) * | 2021-10-12 | 2023-10-13 | 兵器工业卫生研究所 | Real-time mixed inhalation exposure device for multi-component gas of laboratory mice |
| WO2024109897A1 (en) * | 2022-11-24 | 2024-05-30 | 中国科学院深圳先进技术研究院 | Oral/nasal inhalation exposure apparatus capable of observation and recording videos |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106037983B (en) | 2017-12-29 |
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