CN106037638B - A kind of conductivity magnetosonic imaging device and imaging method that removal thermoacoustic effect influences - Google Patents
A kind of conductivity magnetosonic imaging device and imaging method that removal thermoacoustic effect influences Download PDFInfo
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Abstract
A kind of conductivity magnetosonic imaging device and imaging method that removal thermoacoustic effect influences, it is contemplated that influence of the thermoacoustic effect sound source to acoustical signal in magnetosonic coupling imaging.The generation of magnetosonic coupling effect signal is to be acted on by Lorentz force by loading alternating excitation magnetic field in steady magnetic field and generate what once per revolution vibration was realized.Thermoacoustic effect signal is that biological tissue is acted on by the excitation field of alternation, the vibration that electromagnetic wave absorption causes thermal expansion to generate.Method of the invention only uses the signal detection and sample conductivity imaging that a set of imaging device realizes two kinds of effects, sample is placed in magnetostatic field, under the conditions of adding magnetostatic field and being not added two kinds of magnetostatic field, apply the pulse excitation magnetic field of adjustable amplitude and frequency, realizes the acquisition of magneto-acoustic effect signal and thermoacoustic effect signal respectively.The present invention handles the signal of acquisition, removes influence of the thermoacoustic effect to magnetoacoustic signals, realizes that sample distribution of conductivity is rebuild, improves the accuracy of conductivity reconstruction to a certain extent.
Description
Technical field
The present invention relates to a kind of conductivity magnetosonic imaging device and imaging methods.More particularly to a kind of removal thermoacoustic effect
The conductivity magnetosonic imaging device and imaging method of influence.
Background technique
For tumor tissues in the change for having not occurred form, electrical characteristics have occurred that variation, if can extract
The electrical property change information of lesion early stage provides possibility for the early detection of disease.Therefore, noninvasive, safety, knot are constituted
The imaging technique that picture and functional imaging combine increasingly receives significant attention.
Magnetosonic imaging is the method for new bio tissue electrical characteristics imaging.Magnetosonic imaging is to motivate tissue by foreign current
Internal charged ion, while under the action of magnetostatic field, organization internal conductivity information is converted into acoustical signal.Thermoacoustic signal
It is to input imaging organization internal generation induced current by alternating magnetic field to be extracted from acoustical signal by joule thermal excitation acoustical signal
Heat absorption coefficients distributed intelligence carries out electrical characteristics imaging to tissue.
The acoustical signal that obtains is from not only vibration caused by Lorentz force in the magnetosonic imaging of existing apparatus, also source
In the thermoacoustic effect acoustic vibration of no steady magnetic field, only pulsed magnetic field action.Therefore, the so-called magnetosonic that sonic transducer receives
Signal is the superposition for the acoustical signal that both sound sources generate, since both sound sources are all related to conductivity, base used at present
In the conductivity algorithm for reconstructing of lorentz force density divergence sound source design, thermoacoustic effect sound source is not accounted for the shadow of acoustical signal
It rings, the feature of acoustical signal is described with image reconstruction as a result, having differences with the acoustical signal and distribution of conductivity being an actually-received.
Summary of the invention
The technical problem to be solved by the invention is to provide it is a kind of being capable of removal thermoacoustic effect to conductivity accurate reconstruction
The conductivity magnetosonic imaging device and imaging method of influence.
The technical scheme adopted by the invention is that：A kind of conductivity magnetosonic imaging device that removal thermoacoustic effect influences, packet
It includes, couplant slot, is respectively arranged in the couplant slot：It is used to support the pallet of sample, is connected to the bottom of the pallet
The stepper motor for driving pallet to rotate is held, the first sonic transducer and rising tone transducing of the sample two sides are separately positioned on
Device, wherein the input terminal of the stepper motor connects the driving circuit controlled by computer by the conducting wire through couplant slot,
The signal output end of first sonic transducer and the second sonic transducer is all connected with the signal input part of binary channels preamplifier,
The signal output end of the binary channels preamplifier connects computer by capture card, is additionally provided with above the sample sharp
Coil is encouraged, the excitation coil connects exciting bank, is additionally provided with static magnet above the excitation coil.
The exciting bank includes the signal generator being connected for generating pumping signal and is used for described
The power amplifier that amplifies of pumping signal, the output end connection of the power amplifier excitation coil.
The static magnet is the top that the excitation coil is arranged in by the mobile bracket that can be moved.
It is a kind of for remove thermoacoustic effect influence conductivity magnetosonic imaging device imaging method, include the following steps：
1) sample to be tested is acted on into excitation coil by the pulsed sinusoidal driving voltage of exciting bank output frequency 1MHz；
2) the first sonic transducer and the second sonic transducer are passed through by the binary channels preamplifier of high cmrr respectively
Acquire the magnetoacoustic signals and thermoacoustic signal of sample to be tested；
3) to magnetoacoustic signals and thermoacoustic signal digitized processing；
4) frequency-domain analysis is carried out to thermoacoustic signal using Time-Frequency Analysis Method, obtains the frequency domain characteristic of thermoacoustic signal；
5) wave digital lowpass filter is designed according to the frequency domain characteristic of thermoacoustic signal, removes magnetosonic using wave digital lowpass filter
Thermoacoustic signal in signal, isolates single magnetoacoustic signals；
6) using the magnetosonic sound source based on Lorentz force as source item, the acoustic pressure wave equation of magnetosonic sound source is establishedSingle magnetoacoustic signals weight is utilized based on time backprojection algorithm again
The conductivity for building sample to be tested obtains sample distribution of conductivity image.
In step 2) when detecting magnetoacoustic signals, under conditions of loading magnetostatic field, apply the arteries and veins of adjustable amplitude and frequency
Impulse, which is encouraged, acts on excitation coil, using the magnetoacoustic signals of the ultrasonic transducer acquisition sample to be tested of centre frequency 1MHz；
In step 2) when detecting thermoacoustic signal, static magnet is removed by moveable bracket, is being not loaded with magnetostatic field
Under the conditions of, the pulse excitation for applying adjustable amplitude and frequency acts on excitation coil, using the super of 200~500kHz of centre frequency
The thermoacoustic signal of sonic transducer acquisition sample to be tested.
The conductivity magnetosonic imaging device and imaging method that a kind of removal thermoacoustic effect of the invention influences consider thermoacoustic effect
The influence for answering sound source detects the acoustical signal that two kinds of sound sources propagate to body surface sensor position, parses thermoacoustic effect sound source to magnetosonic
The influence that conductivity is rebuild is imaged, list is isolated in the influence that fuel factor sound source generates in the acoustical signal that removal sensor receives
One Lorentz force acoustical signal rebuilds conductivity imaging using original lorentz force density divergence sound source theory and then from acoustical signal
More accurate conductivity information is obtained, the adverse effect of thermoacoustic effect is reduced, improves conductivity imaging quality.
Detailed description of the invention
Fig. 1 is the structural schematic diagram for the conductivity magnetosonic imaging device that present invention removal thermoacoustic effect influences；
Fig. 2 is the imaging method flow chart for the conductivity magnetosonic imaging device that present invention removal thermoacoustic effect influences.
In figure
1：Couplant slot 2：Pallet
3：Sample 4：Stepper motor
5：Driving circuit 6：Computer
7：Capture card 8：Binary channels preamplifier
9：First sonic transducer 10：Second sonic transducer
11：Exciting bank 12：Excitation coil
13：Static magnet 14：Mobile bracket
Specific embodiment
Dress is imaged on the conductivity magnetosonic that a kind of removal thermoacoustic effect of the invention influences below with reference to embodiment and attached drawing
It sets and imaging method is described in detail.
The conductivity magnetosonic imaging device and imaging method that a kind of removal thermoacoustic effect of the invention influences, it is contemplated that magnetosonic
Influence of the thermoacoustic effect sound source to acoustical signal in coupling imaging.The generation of magnetosonic coupling effect signal is by steady magnetic
Alternating excitation magnetic field is loaded in, is acted on by Lorentz force and generates what once per revolution vibration was realized.Thermoacoustic effect signal is to pass through
The excitation field of alternation acts on biological tissue, the vibration that electromagnetic wave absorption causes thermal expansion to generate.Method of the invention only makes
With a set of imaging device realize magnetosonic and the detection of two kinds of effect signals of thermoacoustic with separate.Sample is placed on pallet, is being added
It magnetostatic field and is not added under the conditions of two kinds of magnetostatic field, treats the pulse excitation magnetic field that side sample applies adjustable amplitude and frequency, respectively
Realize the acquisition of the magnetoacoustic signals and thermoacoustic effect signal of sample.Algorithm for design of the present invention handles the signal of acquisition, goes
Fall influence of the thermoacoustic effect to magnetoacoustic signals, realizes that sample distribution of conductivity is rebuild, improve conductivity weight to a certain extent
The accuracy built.
As shown in Figure 1, the conductivity magnetosonic imaging device that a kind of removal thermoacoustic effect of the invention influences, including, coupling
Agent slot 1 is respectively arranged in the couplant slot 1：It is used to support the pallet 2 of sample 3, is connected to the bottom end of the pallet 2
Stepper motor 4 for driving pallet 2 to rotate, the first sonic transducer 9 and the rising tone for being separately positioned on 3 two sides of sample change
Energy device 10, wherein the input terminal of the stepper motor 4 connects the drive controlled by computer 6 by the conducting wire through couplant slot 1
The signal output end of dynamic circuit 5, first sonic transducer 9 and the second sonic transducer 10 is all connected with binary channels preamplifier 8
Signal input part, the signal output end of the binary channels preamplifier 8 connects computer 6, the sample by capture card 7
3 top is additionally provided with excitation coil 12, and the excitation coil 12 connects exciting bank 11, and the exciting bank 11 includes
Be connected for generating the signal generator 111 of pumping signal and the power for amplifying to the pumping signal is put
Big device 112, the output end connection of the power amplifier 112 excitation coil 12.The top of the excitation coil 12 is also
Mobile bracket 14 is provided with static magnet 13.
The static magnet 13 is the top that the excitation coil 12 is arranged in by the mobile bracket 14 that can be moved, from
And load magnetostatic field may be implemented and be not loaded with the different condition of magnetostatic field.By the mobile static magnet of moveable bracket, adding
Under conditions of carrying magnetostatic field, apply the pulse excitation magnetic field of adjustable amplitude and frequency to sample to be tested, realizes magneto-acoustic effect sound letter
Number acquisition.By the mobile static magnet of moveable bracket, under conditions of being not loaded with magnetostatic field, sample to be tested is applied adjustable
The acquisition of thermoacoustic effect acoustical signal is realized in the pulse excitation magnetic field of amplitude and frequency.
First sonic transducer 9 and the second sonic transducer 10 are staggered relatively, while receiving acoustical signal, 9 He of the first sonic transducer
The centre frequency of second sonic transducer 10 is designed according to the requirement of sample conductivity reconstruction information.When measuring biological tissue, the
One sonic transducer, 9 centre frequency is selected as the 1MHz with driving pulse with frequency, and 10 centre frequency of the second sonic transducer is selected as 200~
500kHz。
According to magnetosonic coupling effect acoustic pressure wave equation：
Wherein, p (r, t) is that magnetosonic couples acoustical signal, and it is conductivity according to Ohm's law J=σ E, σ that J, which is current density,
B0For magnetostatic field, csFor the velocity of sound in medium.
According to thermoacoustic coupling effect acoustic pressure wave equation:
Wherein, p (r, t) is that thermoacoustic couples acoustical signal, and β is thermal expansion coefficient, CpFor normal pressure thermal capacitance.
From equation (1) as it can be seen that magneto-acoustic effect signal be as Lorentz force vibrate sound source caused by, can from equation (2)
See, thermoacoustic effect acoustical signal is as caused by Joule heat sound source.Under the measuring condition of magnetosonic imaging, measured acoustical signal was both
Magnetoacoustic signals caused by comprising being vibrated by Lorentz force, the thermoacoustic signal also generated comprising thermoacoustic effect.
Of the invention is a kind of for removing the imaging method of the conductivity magnetosonic imaging device of thermoacoustic effect influence, by going
Except the thermoacoustic signal in magnetoacoustic signals to realize Exact Reconstruction tested sample distribution of conductivity image, as shown in Fig. 2, specifically including
Following steps：
1) sample to be tested is acted on into excitation coil by the pulsed sinusoidal driving voltage of exciting bank output frequency 1MHz；
2) the first sonic transducer and the second sonic transducer are passed through by the binary channels preamplifier of high cmrr respectively
Acquire the magnetoacoustic signals and thermoacoustic signal of sample to be tested；Wherein
When detecting magnetoacoustic signals, under conditions of loading magnetostatic field, the pulse excitation for applying adjustable amplitude and frequency is made
For excitation coil, using the magnetoacoustic signals of the ultrasonic transducer acquisition sample to be tested of centre frequency 1MHz；
When detecting thermoacoustic signal, applied under conditions of being not loaded with magnetostatic field by the mobile static magnet of moveable bracket
The pulse excitation of adjustable amplitude and frequency is added to act on excitation coil, using the ultrasonic transducer of 200~500kHz of centre frequency
Acquire the thermoacoustic signal of sample to be tested.
3) to magnetoacoustic signals and thermoacoustic signal digitized processing；
4) frequency-domain analysis is carried out to thermoacoustic signal using Time-Frequency Analysis Method, obtains the frequency domain characteristic of thermoacoustic signal；
5) wave digital lowpass filter is designed according to the frequency domain characteristic of thermoacoustic signal, removes magnetosonic using wave digital lowpass filter
Thermoacoustic signal in signal isolates single Lorentz force magnetoacoustic signals；
6) using the magnetosonic sound source based on Lorentz force as source item, the acoustic pressure wave equation of magnetosonic sound source is establishedSingle magnetoacoustic signals weight is utilized based on time backprojection algorithm again
The conductivity for building sample to be tested obtains sample distribution of conductivity image.
Example is given below：
1) sample to be tested 3 is fixed below the excitation coil in device as shown in Figure 1, passes through shifting above couplant slot 1
Dynamic bracket 14 places the uniform magnetic field of the formation of static magnet 13 perpendicular to sample holding plane, and the first sonic transducer 9 and the rising tone change
Energy device 10 is symmetrically disposed at 3 plane two sides of sample in the horizontal direction；
2) it when detecting thermoacoustic signal, using the sinusoidal impulse voltage drive sample of 1MHz frequency, is moved by mobile bracket 14
The effect that static magnet 13 removes homogeneous static magnetic field is walked, with the first of the second sonic transducer of centre frequency 200-500kHz and 1MHz
Sonic transducer acquires signal, receives signal using binary channels preamplifier 8, controls motor drive by computer and is placed with sample
3 pallet 2 rotates, and making the first sonic transducer 9 and the second sonic transducer 10, circumferentially scanning mode acquires signal point by point, obtains each
The thermoacoustic signal of sample 3 at collection point；
3) it when detecting magnetoacoustic signals, using the sinusoidal impulse voltage drive sample of 1MHz frequency, is moved by mobile bracket 14
For sound magnet 13 to the underface of sample 3, the intensity that magnetostatic field is arranged is 1T, while with the second of centre frequency 200-500kHz
The first sonic transducer of sonic transducer and 1MHz acquire signal, receive signal using binary channels preamplifier, pass through computer
Control motor drives the pallet 2 for being placed with sample 3 to rotate, and makes the first sonic transducer 9 and the second sonic transducer 10 circumferentially scanning side
Formula acquires signal point by point, obtains the magnetoacoustic signals of sample 3 at each collection point；
4) for the signal of each station acquisition, in the magnetoacoustic signals received using Time-frequency Analysis removal sensor
Thermoacoustic effect influence, isolate single Lorentz force acoustical signal；
5) equation is solved
Corresponding algorithm is obtained, data obtained in step 4) are inputted into algorithm, sample distribution of conductivity is rebuild.
In the case that this method and step are equally applicable to driving pulse as other frequencies, it is not limited only to 1MHz.At this point, the
The centre frequency of one sonic transducer should be consistent with driving pulse frequency.When measuring biological tissue, 10 center of the second sonic transducer
Frequency is selected as 200~500kHz.
Claims (6)
1. a kind of conductivity magnetosonic imaging device that removal thermoacoustic effect influences, including, couplant slot (1), which is characterized in that institute
It is respectively arranged in the couplant slot (1) stated：It is used to support the pallet (2) of sample (3), is connected to the bottom end of the pallet (2)
The first sonic transducer (9) in the sample (3) side and setting is arranged in stepper motor (4) for driving pallet (2) to rotate
The second sonic transducer (10) in the sample (3) other side, wherein the input terminal of the stepper motor (4) is by running through coupling
The conducting wire of mixture slot (1) connects the driving circuit (5) controlled by computer (6), and first sonic transducer (9) and the rising tone change
The signal output end of energy device (10) is all connected with the signal input part of binary channels preamplifier (8), the preposition amplification of binary channels
The signal output end of device (8) connects computer (6) by capture card (7), is additionally provided with excitation coil above the sample (3)
(12), the excitation coil (12) connects exciting bank (11), is additionally provided with static magnet above the excitation coil (12)
(13)。
2. a kind of conductivity magnetosonic imaging device that removal thermoacoustic effect influences according to claim 1, which is characterized in that
The exciting bank (11) includes the signal generator (111) being connected for generating pumping signal and is used for described
The power amplifier (112) that amplifies of pumping signal, the output end connection of the power amplifier (112) excitation
Coil (12).
3. a kind of conductivity magnetosonic imaging device that removal thermoacoustic effect influences according to claim 1, which is characterized in that
The static magnet (13) is top of mobile bracket (14) setting by that can move in the excitation coil (12).
4. a kind of imaging method of the conductivity magnetosonic imaging device influenced for removal thermoacoustic effect described in claim 1,
It is characterised in that it includes following steps：
1) sample to be tested is acted on into excitation coil by the pulsed sinusoidal driving voltage of exciting bank output frequency 1MHz；
2) the first sonic transducer is passed through by the binary channels preamplifier of high cmrr respectively and the second sonic transducer acquires
The magnetoacoustic signals and thermoacoustic signal of sample to be tested；
3) to magnetoacoustic signals and thermoacoustic signal digitized processing；
4) frequency-domain analysis is carried out to thermoacoustic signal using Time-Frequency Analysis Method, obtains the frequency domain characteristic of thermoacoustic signal；
5) wave digital lowpass filter is designed according to the frequency domain characteristic of thermoacoustic signal, removes magnetoacoustic signals using wave digital lowpass filter
In thermoacoustic signal, isolate single magnetoacoustic signals；
6) using the magnetosonic sound source based on Lorentz force as source item, the acoustic pressure wave equation of magnetosonic sound source is establishedSingle magnetoacoustic signals weight is utilized based on time backprojection algorithm again
The conductivity for building sample to be tested obtains sample distribution of conductivity image.
5. the imaging method for the conductivity magnetosonic imaging device that removal thermoacoustic effect according to claim 4 influences, special
Sign is, in step 2) when detecting magnetoacoustic signals, under conditions of loading magnetostatic field, applies the pulse of adjustable amplitude and frequency
Incentive action is in excitation coil, using the magnetoacoustic signals of the ultrasonic transducer acquisition sample to be tested of centre frequency 1MHz.
6. the imaging method for the conductivity magnetosonic imaging device that removal thermoacoustic effect according to claim 4 influences, special
Sign is, in step 2) when detecting thermoacoustic signal, static magnet is removed by moveable bracket, in the item for being not loaded with magnetostatic field
Under part, the pulse excitation for applying adjustable amplitude and frequency acts on excitation coil, using the ultrasound of 200~500kHz of centre frequency
The thermoacoustic signal of energy converter acquisition sample to be tested.
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| CN110236540B (en) * | 2019-06-30 | 2023-03-24 | 中国医学科学院生物医学工程研究所 | Deep vein thrombus removing and developing device based on magnetoacoustic coupling effect |
| CN111175371A (en) * | 2020-01-10 | 2020-05-19 | 中国医学科学院生物医学工程研究所 | Two-dimensional focusing scanning magnetic acoustic imaging device |
| CN112504945B (en) * | 2020-11-09 | 2022-10-21 | 中国科学院电工研究所 | Fluid electrical parameter measuring device of magnetoacoustic coupling effect |
| CN112683992B (en) * | 2020-12-22 | 2022-05-17 | 中国医学科学院生物医学工程研究所 | Positioning device and method capable of simultaneously detecting magnetic acoustic signals and electric field by noise-containing shielding |
| CN113057584B (en) * | 2021-03-12 | 2023-01-20 | 中国科学院电工研究所 | Magnetic-acoustic coupling brace for in-vivo detection of small animals |
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