CN113057584B - Magnetic-acoustic coupling brace for in-vivo detection of small animals - Google Patents
Magnetic-acoustic coupling brace for in-vivo detection of small animals Download PDFInfo
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- CN113057584B CN113057584B CN202110271267.4A CN202110271267A CN113057584B CN 113057584 B CN113057584 B CN 113057584B CN 202110271267 A CN202110271267 A CN 202110271267A CN 113057584 B CN113057584 B CN 113057584B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/42—Details of probe positioning or probe attachment to the patient
- A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
- A61B8/4281—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by sound-transmitting media or devices for coupling the transducer to the tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
Abstract
A magnetoacoustic coupling brace for in-vivo detection of small animals comprises a coupling groove (A), a hanging basket type small animal sample fixing support, a phased array ultrasonic transducer (C) and an electromagnetic coil. The hanging basket type small animal sample fixing support and the phased array ultrasonic transducer (C) are positioned in the coupling groove (A). The coupling groove (A) is arranged in the static magnetic field, and the bottom surface is vertical to the magnetic field direction of the static magnetic field. The electromagnetic coil is positioned at the bottom outside the coupling groove or above the coupling medium in the coupling groove and is not in contact with the coupling liquid. And the hanging basket type small animal sample fixing support (B) is positioned at the center of the top of the coupling groove (A), and the small animal sample is arranged on the hanging basket type small animal sample fixing support and is positioned in the effective magnetic field intensity area of the electromagnetic coil. The emission ultrasound plane of the phased array ultrasound transducer (C) is perpendicular to the magnetic field direction of the static magnetic field. And a sound insulation pad is arranged between the coupling groove (A) and the electromagnetic coil and is used for isolating sound wave signals generated by the vibration of the electromagnetic coil in a static magnetic field.
Description
Technical Field
The invention relates to a device for the in-vivo detection of small animals.
Background
The magnetoacoustic imaging technology realizes biological tissue conductivity imaging by combining electromagnetic field excitation and ultrasonic detection, has the advantages of high contrast and high resolution, and has potential application value in tumor mechanism research and early cancer detection. In the magnetic acoustic detection system, the electromagnetic field and the acoustic field realize coupling conversion through a detected target body, and the spatial reconstruction of the conductivity of the detected target is realized by using a detected signal.
On one hand, because the magnetoacoustic signals are transmitted in a single pass, the accuracy of spatial positioning of the sample and the detection device directly influences the quality and precision of the inverted image, and the design of a portable and accurate coupling support is particularly important. On the other hand, in the magnetoacoustic detection, the imaging quality is better as the number of sampling points is larger. For the ultrasonic transducer array, the number of array elements is a fixed value, and in order to increase the number of sampling points, the ultrasonic transducer array is detected for multiple times from different angles, so that the image resolution is effectively improved. Therefore, the problem of spatial positioning of the exciting coil, the sample and the detection device needs to be solved through the design of the coupling support.
For living animal experiments, the vital signs of animals need to be monitored in real time in the experiments, and breathing channels need to be reserved, and the animal postures in an anesthesia state are difficult to maintain, so that a fixing brace capable of solving the problems needs to be designed.
Disclosure of Invention
The invention provides a magnetoacoustic coupling brace for small animal in-vivo detection, aiming at in-vivo detection of small animals.
The invention relates to a magnetoacoustic coupling brace for in-vivo detection of small animals, which takes insulating oil or deionized water as a coupling medium and utilizes a hanging basket type small animal sample fixing support in a coupling groove body to realize in-vivo magnetoacoustic detection of small animals. All parts of the invention are made by cutting acrylic plates.
The magnetic-acoustic coupling brace for in-vivo detection of the small animal comprises a coupling groove, a hanging basket type small animal sample fixing support, a phased array ultrasonic transducer and an electromagnetic coil. The coupling groove is a cuboid or a cylinder and is placed in a static magnetic field, and a coupling medium is contained in the coupling groove. The bottom surface of the coupling groove is perpendicular to the magnetic field direction of the static magnetic field. The hanging basket type small animal sample fixing support and the phased array ultrasonic transducer are positioned in the coupling groove; the hanging basket type small animal sample fixing support is positioned at the center of the top of the coupling groove and is supported by the groove wall of the coupling groove; the electromagnetic coil is positioned at the bottom outside the coupling groove or above the coupling medium in the coupling groove and is not in contact with the coupling liquid. The small animal sample is arranged on the hanging basket type small animal sample fixing support and is positioned in the effective magnetic field intensity area of the electromagnetic coil.
Phased array ultrasonic transducer and phased array ultrasonic transducer support locating piece are placed to coupling groove inside. The emission ultrasonic plane of the phased array ultrasonic transducer is vertical to the magnetic field direction of the static magnetic field. The phased array ultrasonic transducer support positioning block is annular and provided with a protrusion and is placed in the coupling groove. The center position of the bottom surface in the coupling groove is provided with a sinking groove for placing a sample. The phased array ultrasonic transducer support positioning blocks are arranged around the lower chute and are concentric with the lower chute. An electrode lead groove is formed in the bottom surface of the coupling groove and is communicated with the sinking groove, an electric wire is placed in the electrode lead groove, one end of the electric wire is connected with an electrode in the sinking groove, and the other end of the electric wire is connected with a detection circuit or a magnetic-acoustic excitation source according to different adopted magnetic-acoustic imaging modes; the electrode is placed in the sink tank and connected with the sample in the sink tank. The position of the phased array ultrasonic transducer is fixed under the positioning of the phased array ultrasonic transducer support positioning block, and the position does not deviate during detection.
The inner bottom surface of the coupling groove is also provided with a positioning groove. The positioning grooves are concentrically arranged around the sink for placing the sample to form a ring. The positioning groove is a groove for placing cushion blocks with different heights, and the length, width, size and shape of the cushion blocks are the same as those of the positioning groove. And the scanning of the phased array ultrasonic transducer on different faults of the sample is realized by adjusting the height of the cushion block in the positioning groove.
The bottom surface in the coupling groove is also provided with a sunken liquid collecting groove and an inclined flow channel, and the inclined flow channel is communicated with the sunken liquid collecting groove. The outer bottom surface of the coupling groove is provided with a lead groove and a lead channel, the electromagnetic coil is positioned in the lead groove, and the lead groove realizes the limit of the electromagnetic coil. And a lead of the electromagnetic coil is led out through a lead channel at the bottom of the coupling groove. The lead groove is coaxial with a sink groove for placing a sample in the phased array ultrasonic transducer support positioning block in the coupling groove. The electromagnetic coil can also be positioned above the coupling medium in the coupling groove and is not in contact with the coupling medium, the center of the electromagnetic coil is concentric with the center of the sinking groove, and the sinking groove can be circular or square. And a sound insulation pad is arranged between the coupling groove and the electromagnetic coil and is used for isolating sound wave signals generated by the vibration of the electromagnetic coil in a static magnetic field.
The phased array ultrasonic transducer can be a ring phased array or a linear phased array.
And the liquid collecting tank collects residual coupling medium after the experiment and discharges the coupling medium through the inclined flow channel. Under the non-working condition, the coupling medium is ensured not to contact the phased array ultrasonic transducer, so that the phased array ultrasonic transducer is protected.
The hanging basket type small animal sample fixing support is composed of three parts: apron, carousel and regulation support. The cover plate is of a T-shaped structure, and a round hole is formed in the center of the cover plate. The constant head tank of sample comprises a concentric circle by the recess of a plurality of the same radians, the sample constant head tank of round hole and coupling groove bottom surface is concentric, and the distance at three long limit edge and the apron center of apron equals, and the border on each long limit of apron is opened there is the draw-in groove, and the apron is fixed in the coupling groove top through this draw-in groove. The middle of the cover plate is of a hollowed circular structure, and the edge of the hollowed circular structure is provided with a sunken groove for fixing the turntable. The short side perpendicular to the three long sides of the T-shaped cover plate is an operation surface, three scale lines are arranged on the edge of the operation surface, the included angle between every two adjacent scale lines is 1.875 degrees, the position of a sample can be changed by rotating a disc, scanning data of different angles are increased, the number of sampling points is increased, the imaging quality is improved, and small holes which are arranged in an array mode are formed in the operation surface and used for fixing four limbs of small animals; the turntable is of a hollow disc structure, and the outer side of the turntable is just meshed with the groove of the cover plate. The middle symmetrical position of the rotary table is provided with a rectangular groove for fixing the adjusting bracket. The edge of the rotary table is marked with scales which are matched with the scales of the upper short edge of the cover plate, so that small-range adjustment of different angles is realized.
Drawings
FIG. 1 is an assembly view of the general structure of the present invention;
FIG. 2a is a top view of a coupling groove of the present invention, and FIG. 2b is a bottom view of the coupling groove of the present invention;
FIG. 3a is a schematic view of a cover plate according to the present invention; FIG. 3b is a detailed view of the cover plate;
FIG. 4a is a schematic view of a descending step of the rotary table, and FIG. 4b is a detailed view of the rotary table;
FIG. 5 is a schematic view of an adjustment bracket of the present invention;
in the figure, a coupling groove A, a hanging basket type small animal sample fixing support B, a phased array ultrasonic transducer support positioning block 1, a positioning groove 2, a sinking groove 3, an electrode lead groove 4, a liquid collecting groove 5, a flow channel 6, a lead groove 7, a lead channel 8, a clamping groove 9, a round hole 10, a round clamping groove 11, a scale groove 12, a sinking step 13, a sample support clamping groove 15, a rotary positioning mark 16, an adjusting support 17 and a small hole 18.
Detailed Description
The invention is further described with reference to the following figures and detailed description.
As shown in figure 1, the magnetoacoustic coupling support for in-vivo detection of small animals uses insulating oil or deionized water as a coupling medium, and realizes in-vivo magnetoacoustic detection of small animals by using a hanging basket type small animal sample fixing support B in a coupling groove A. All parts of the invention are made by cutting acrylic plates.
The magnetic-acoustic coupling support for in-vivo detection of the small animal comprises a coupling groove A, a hanging basket type small animal sample fixing support B, a phased array ultrasonic transducer C and an electromagnetic coil, wherein the hanging basket type small animal sample fixing support B is positioned at the center of the top of the coupling groove A and is supported by the groove wall of the coupling groove A; the coupling groove A is cuboid or circular, and the hanging basket type small animal sample fixing support B and the phased array ultrasonic transducer C are located in the coupling groove A. Electromagnetic coil can be located coupling groove outside bottom or interior survey coupling medium upper end, but contactless coupling liquid guarantees simultaneously that the sample is located electromagnetic coil's effective magnetic field intensity region.
The coupling groove A is a cuboid or a cylinder and is placed in the static magnetic field, and the bottom surface of the coupling groove A is perpendicular to the magnetic field direction of the static magnetic field. A phased array ultrasonic transducer support positioning block 1 is placed in the coupling groove, a liquid collecting groove 5 and a flow channel 6 are formed in the inner bottom surface of the coupling groove, and a lead groove 7 used for limiting an electromagnetic coil and a lead channel 8 used for leading out the electromagnetic coil are formed in the outer bottom surface of the coupling groove A. The phased array ultrasonic transducer C positioned in the coupling groove A can be an annular phased array or a linear phased array; the emission ultrasound plane of the phased array ultrasound transducer C is perpendicular to the magnetic field direction of the static magnetic field. The phased array ultrasonic transducer support positioning blocks 1 are multiple and form a ring for adjusting the placement position of a phased array ultrasonic transducer, the phased array ultrasonic transducer support positioning blocks 1 are arranged around a sinking groove 3 for placing a sample and are coaxial with the sinking groove 3, and the sinking groove 3 is positioned at the center of the inner bottom surface of the coupling groove. An electrode lead slot 4 is further formed in the inner bottom surface of the coupling slot, the electrode lead slot 4 is communicated with the sink slot 3, an electric wire is placed in the electrode lead slot 4, one end of the electric wire is connected with an electrode in the sink slot 3, and the other end of the electric wire is connected with a detection circuit or a magnetic sound excitation source according to different adopted magnetic sound imaging modes; the electrode is arranged in the sink tank 3 and is in direct contact connection with the sample in the sink tank 3. The phased array ultrasonic transducer support positioning block 1 is used for positioning the detection position of the phased array ultrasonic transducer C, so that a sample in the sink groove 3 is positioned in an effective detection area of the phased array ultrasonic transducer and does not deviate in position during detection. The bottom surface in the coupling groove A is also provided with a sunken positioning groove 2, the positioning groove 2 is a groove, and a plurality of positioning grooves 2 are arranged around a sunken groove 3 for placing samples and are concentric with the sunken groove 3 to form a ring. The positioning groove 2 is internally provided with cushion blocks with the same length, width and shape as the positioning groove, the cushion blocks with different heights are utilized, the phased array ultrasonic transducer C is combined to realize non-deviation of a plane position under the positioning of the phased array ultrasonic transducer support positioning block 1, and the scanning of the phased array ultrasonic transducer C on different faults of a sample is realized by adjusting the heights of the cushion blocks in the positioning groove 2. The submerged liquid collecting groove 5 on the inner bottom surface of the coupling groove is communicated with the inclined flow channel 6, and the liquid collecting groove 5 collects residual coupling media after the experiment. Under the non-working condition, the coupling medium does not contact the phased array ultrasonic transducer so as to protect the phased array ultrasonic transducer. And a lead groove 7 is formed in the outer bottom surface of the coupling groove A, and the lead groove 7 is coaxial with the sink groove 3 for placing the sample in the coupling groove and is used for limiting the electromagnetic coil and leading out the lead. The electromagnetic coil is positioned in the lead groove 7 on the outer bottom surface of the coupling groove A or is positioned above the coupling medium in the coupling groove, but does not contact the coupling medium. The sample is arranged on a hanging basket type small animal sample fixing support B and is positioned in the effective magnetic field intensity of the electromagnetic coil. And a sound insulation pad is arranged between the coupling groove A and the electromagnetic coil and is used for isolating sound wave signals generated by the vibration of the electromagnetic coil in a static magnetic field.
The hanging basket type small animal sample fixing support B comprises three components: apron, carousel and regulation support. As shown in fig. 3a and 3b, the cover plate is a "T" shaped structure, and a circular hole is formed in the center of the cover plate, and is concentric with the positioning groove 2 at the bottom in the coupling groove a. The distance at three long limit edges of apron equals with the apron center, and the border on each long limit of apron is opened has draw-in groove 9, and the apron is fixed in on the side at coupling groove top through this draw-in groove 9. The middle of the cover plate is of a hollowed circular structure, a round hole 10 is formed in the center of the hollowed circular structure, the center of the round hole 10 is concentric with the sinking groove 3 at the bottom of the coupling groove A, and sinking grooves are formed in the edge of the hollowed circular structure and used for fixing the rotary table. The rotary table is placed in the round hole 10 of the cover plate and fixed through the round clamping groove 11, the adjusting support is fixed in the round clamping groove 11 of the rotary table, and the upper surface of the rotary table is aligned with the upper surface of the cover plate. The edge of the central circular hole 10 of the T-shaped cover plate is a sunken circular clamping groove 11 for fixing the sample turntable. The periphery of the central circular hole 10 of the T-shaped cover plate is provided with a scale groove 12 which is used for rotary positioning and is provided with scales.
The short side perpendicular to the three long sides of the T-shaped cover plate is an operation surface, three scale lines are arranged on the edge of the operation surface, the included angle between every two adjacent scale lines is 1.875 degrees, the position of a sample can be changed by rotating the rotary table, scanning data of different angles are increased, the number of sampling points is increased, the imaging quality is improved, and small holes which are arranged in an array mode are formed in the operation surface and used for fixing four limbs of small animals; the turntable is of a hollow disc structure, and the outer side of the turntable is meshed with the groove of the cover plate. Rectangular grooves are formed in the middle of the rotary table symmetrically and used for fixing the adjusting bracket 17. The edge of the rotary table is marked with scales which are matched with the scales of the short edge of the cover plate, so that small-range adjustment of different angles is realized.
The structure of the rotating disc is shown in fig. 4a and 4 b. The turntable is a hollow disc and is made of an acrylic plate. The circumferential edge of the inner side of the rotary disc is a sunken step 13 which is matched with the circular clamping groove 11 on the cover plate. The outer side surface of the turntable is provided with a rotary positioning mark 16, and the rotary positioning mark 16 is matched with the scale groove 12 of the cover plate to realize small-angle rotary positioning of the sample. The rotary disc is provided with sample support clamping grooves 15 which are symmetrically arranged, and the sample support clamping grooves 15 are matched with an adjusting support 17 and used for fixing samples.
The structure of the adjusting bracket 17 is shown in fig. 5, the adjusting bracket is T-shaped and is made of acrylic plates. The upper side beam is fixed in the sample support clamping groove 15 on the turntable, and is matched with the sample support clamping groove 15 to fix the adjusting support 17. The T-shaped adjusting bracket 17 is provided with small holes 18 which are arranged in an array, and the small holes 18 are filled with silica gel and used for fixing limbs of small animals or a sample basket.
The magnetoacoustic coupling brace for in-vivo detection of the small animal can be used for magnetoacoustic imaging and magnetoacoustic electric imaging.
Claims (1)
1. A magnetoacoustic coupling brace for in vivo detection of small animals, comprising: the support comprises a coupling groove (A), a hanging basket type small animal sample fixing support, a phased array ultrasonic transducer (C) and an electromagnetic coil; the coupling groove (A) is a cuboid or a cylinder and is placed in a static magnetic field, and the bottom surface of the coupling groove (A) is vertical to the magnetic field direction of the static magnetic field; the hanging basket type small animal sample fixing support (B) and the phased array ultrasonic transducer (C) are positioned in the coupling groove (A); the hanging basket type small animal sample fixing support (B) is positioned at the center of the top of the coupling groove (A) and is supported by the groove wall of the coupling groove (A); the small animal sample is arranged on the hanging basket type small animal sample fixing bracket and is positioned in the effective magnetic field intensity area of the electromagnetic coil; the electromagnetic coil is positioned at the outer bottom of the coupling groove or above the coupling medium in the coupling groove and is not in contact with the coupling liquid; the phased array ultrasonic transducer (C) is an annular phased array or a linear phased array; the ultrasonic emission plane of the phased array ultrasonic transducer (C) is vertical to the magnetic field direction of the static magnetic field; a sound insulation pad is arranged between the coupling groove (A) and the electromagnetic coil and is used for isolating sound wave signals generated by the vibration of the electromagnetic coil in a static magnetic field;
a phased array ultrasonic transducer support positioning block (1) is arranged in the coupling groove (A); the phased array ultrasonic transducer support positioning blocks (1) are annular, and a plurality of phased array ultrasonic transducer support positioning blocks (1) are arranged around the sinking groove (3) and are concentric with the sinking groove (3); the sinking groove (3) is positioned at the central position of the bottom in the coupling groove and is used for placing a sample; the phased array ultrasonic transducer support positioning block (1) is used for positioning a sample detection position, so that a sample in the sink groove (3) is positioned in an effective detection area of the phased array ultrasonic transducer and does not deviate in position during detection;
the inner bottom surface of the coupling groove (A) is provided with positioning grooves (2), and a plurality of positioning grooves (2) are concentrically arranged around a sink groove (3) for placing a sample to form a circular ring; the positioning groove (2) is a groove and is used for placing cushion blocks with different heights, the length, width, size and shape of the cushion blocks are the same as those of the positioning groove (2), and the phased array ultrasonic transducer is used for scanning on different sample faults by adjusting the height of the cushion blocks in the positioning groove (2);
the inner bottom surface of the coupling groove (A) is provided with a liquid collecting groove (5) and an inclined flow channel (6), the liquid collecting groove (5) is communicated with the inclined flow channel (6), and the liquid collecting groove (5) collects residual coupling medium and discharges the coupling medium out of the coupling groove (A) through the flow channel (6);
a lead groove (7) is formed in the outer bottom surface of the coupling groove (A), and the lead groove (7) is coaxial with the sinking groove (3) and used for limiting the electromagnetic coil and leading out the lead; the electromagnetic coil is positioned in the lead groove (7) or is placed above the coupling medium in the coupling groove (A) and is not in contact with the coupling medium;
the hanging basket type small animal sample fixing bracket (B) comprises three components: the device comprises a cover plate, a rotary table and an adjusting bracket; the cover plate is T-shaped, a round hole is formed in the center of the cover plate, and the round hole is concentric with the positioning groove (2); the distances between the edges of the three long edges of the cover plate and the center of the cover plate are equal, the edges of the long edges of the cover plate are provided with clamping grooves (9), and the cover plate is fixed on the side edge of the top of the coupling groove through the clamping grooves (9); the middle of the cover plate is of a hollowed circular structure, a round hole (10) is formed in the center of the hollowed circular structure, the center of the round hole (10) is concentric with the sink groove (3), and a sink groove is formed in the edge of the hollowed circular structure and used for fixing the turntable; the rotary table is placed in a circular hole (10) of the cover plate and fixed by a circular clamping groove (11), the adjusting bracket is fixed in the circular clamping groove (11) of the rotary table, and the upper surface of the rotary table is aligned with the upper surface of the cover plate; the edge of a central round hole (10) of the T-shaped cover plate is provided with a sunken round clamping groove (11) for fixing the sample turntable; the periphery of the central circular hole (10) of the T-shaped cover plate is provided with a scale groove (12) which is used for rotary positioning and is provided with scales; the short side perpendicular to the three long sides of the T-shaped cover plate is an operation surface, the edge of the operation surface is provided with three scale lines, and the included angle between every two adjacent scale lines is 1.875 DEG; the operation surface is provided with small holes which are arranged in an array manner and used for fixing limbs of small animals;
the rotary disc is a hollow disc, and the outer side of the rotary disc is meshed with the groove of the cover plate; rectangular grooves are formed in the middle of the rotary table symmetrically and used for fixing the adjusting bracket (17); scales are marked on the edge of the rotary table and matched with the scales on the upper short edge of the cover plate, so that small-range adjustment of different angles is realized; the circumferential edge of the inner side of the rotary disc is provided with a sunken step (13) which is matched with a circular clamping groove (11) on the cover plate; the outer side surface of the turntable is provided with a rotary positioning mark (16), and the rotary positioning mark (16) is matched with a scale groove (12) of the cover plate to realize small-angle rotary positioning of a sample; sample support clamping grooves (15) are symmetrically arranged on the rotary disc, and the sample support clamping grooves (15) are matched with the adjusting support (17) and used for fixing samples;
the adjusting bracket (17) is T-shaped, and the upper side beam is fixed in a sample bracket clamping groove (15) on the turntable and is matched with the sample bracket clamping groove (15) to fix the adjusting bracket (17); the T-shaped adjusting bracket (17) is provided with small holes (18) which are arranged in an array manner, and the small holes (18) are filled with silica gel and used for fixing limbs of small animals or a sample basket.
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| CN114224298B (en) * | 2022-01-17 | 2023-12-01 | 中国科学院电工研究所 | Magneto-acoustic electric imaging system and method under nuclear magnetic resonance |
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