CN105999367A - Surgical medical dressing and preparation method thereof - Google Patents
Surgical medical dressing and preparation method thereof Download PDFInfo
- Publication number
- CN105999367A CN105999367A CN201610641729.6A CN201610641729A CN105999367A CN 105999367 A CN105999367 A CN 105999367A CN 201610641729 A CN201610641729 A CN 201610641729A CN 105999367 A CN105999367 A CN 105999367A
- Authority
- CN
- China
- Prior art keywords
- medical dressing
- acid
- sodium alginate
- filtrate
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000000661 sodium alginate Substances 0.000 claims abstract description 31
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 31
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229920001661 Chitosan Polymers 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 16
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 16
- 239000000835 fiber Substances 0.000 claims abstract description 15
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 14
- 230000005855 radiation Effects 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 238000004108 freeze drying Methods 0.000 claims abstract description 7
- 238000001356 surgical procedure Methods 0.000 claims description 37
- 239000000706 filtrate Substances 0.000 claims description 33
- 230000033228 biological regulation Effects 0.000 claims description 14
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 8
- 239000011246 composite particle Substances 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 claims description 6
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 claims description 6
- 229960003321 baicalin Drugs 0.000 claims description 6
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
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- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 6
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- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 4
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 4
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 4
- 238000005516 engineering process Methods 0.000 claims description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- KBIWNQVZKHSHTI-UHFFFAOYSA-N 4-n,4-n-dimethylbenzene-1,4-diamine;oxalic acid Chemical compound OC(=O)C(O)=O.CN(C)C1=CC=C(N)C=C1 KBIWNQVZKHSHTI-UHFFFAOYSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- 235000011054 acetic acid Nutrition 0.000 claims description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 2
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- 239000011976 maleic acid Substances 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
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- IUMKBGOLDBCDFK-UHFFFAOYSA-N dialuminum;dicalcium;iron(2+);trisilicate;hydrate Chemical compound O.[Al+3].[Al+3].[Ca+2].[Ca+2].[Fe+2].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IUMKBGOLDBCDFK-UHFFFAOYSA-N 0.000 abstract 1
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Classifications
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A—HUMAN NECESSITIES
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention provides a surgical medical dressing. The surgical medical dressing is prepared from biological raw materials such as a chitosan derivative and sodium alginate fibers, wherein the chitosan derivative is carboxymethyl chitosan quaternary ammonium salt. The preparation method comprises acidizing sodium alginate fibers, processing the acidized sodium alginate fibers to obtain powder, mixing the powder and olivine or epidote, then swelling the mixture particles, and carrying out microwave radiation and freeze-drying to obtain the surgical medical dressing. The prepared surgical medical dressing has good moisture permeability, water absorptivity, water retentivity and biodegradability.
Description
Technical field
The present invention relates to a kind of surgery medical dressing, it is possible to for medical rescue field.
Background technology
Surgery medical dressing, is the articles for use of bag wound, in order to cover skin ulcer, wound or the medical material of other infringements.Along with the physiopathologic further investigation to wound, people are more deep to the understanding of wound, thus result in updating and developing of Medical wounded surface dressing.Today, novel wound surface nursing dressing, for early stage, has occurred that revolutionary change, and the surgery medical dressing of multiple different performance is available for clinical nursing staff and selects.At present, alginate dressing is international relatively advanced surgery medical dressing.Various surgery medical dressing are respectively arranged with pluses and minuses, (one) natural gauze be use the earliest, a most commonly used class dressing.Advantage: 1, powerful and quickly to absorb wound surface transudate 2, process of manufacture fairly simple;Shortcoming: 1, permeability is the highest, easily make wound surface dehydration 2, adhesion wound surface, can cause during replacing again property mechanical injuries 3, external environment microorganism easily by, the chance of cross infection compared with high by 4, consumption is many, changes frequent, time-consuming, and patient suffering is due to the minimizing of natural resources, the cost of gauze is also being gradually increased, therefore, in order to avoid excessive use natural resources, occur in that surgery medical dressing is processed in application macromolecular material (synthetic fibers), here it is synthetic fibers class dressing.(2) surgery medical dressing synthetic fibers class dressing: this kind of dressing has the advantage that gauze is the same, such as economy, and has good absorbent properties etc., and, some product also has autohension so that it is use easily.But, this series products has the shortcoming that gauze is the same equally, as high in permeability, to external world ambient particle contact scar thing without hindrance every etc..(3) surgery medical dressing many poly film class dressing: this is the dressing that a class is more advanced, having the gas such as oxygen, steam can be the most penetrating, and intransitable feature such as graininess foreign body such as dust and microorganism etc. in environment.Advantage: 1, intercept environmental microorganism invasion wound surface, prevent cross infection 2, have moisture retention, wound surface is made to moisten, will not adhere wound surface, from without producing mechanical injuries of property again 3 when changing, having autohension, easy to use, and it is transparent, being easy to observe wound surface situation shortcoming: 1, absorb that sepage ability 2, cost are of a relatively high 3, wound surface surrounding skin impregnator can be big, the most this kind of dressing is mainly applied to postoperative and oozes out few wound surface, or the complementary dressing as other dressing.(4) surgery medical dressing foaming polymer class dressing this be the dressing that a class foams via macromolecular material (PU), surface often covers one layer of poly semipermeable membrane, and some also has autohension.Advantage: 1, quick and powerful transudate absorbability 2, saturating property are low, wound surface is made to keep moistening, avoid during more change dressings, property mechanical injuries 3, the barrier property of surface semipermeable membrane again, the intrusion of ambient particle foreign body such as dust and microorganism can be prevented, guard against cross infection 4, easy to use, compliance good, can be suitable for corporal parts 5, heat-insulation and heat-preservation, buffering external world impulse force.Shortcoming: 1, due to the strongest absorbent properties, oozing out wound surface for minuent, may to have influence on self debridement process 2, cost of a relatively high 3, because of opaque, be inconvenient to observe the medical dressing hydrocolloid class dressing of wound surface (five) surgery: its main component is hydrocolloid sodium carboxymethyl cellulose granule (CMC) that a kind of hydrophilic ability is the strongest, viscose glue medical with hypoallergenic, collectively forming dressing main body plus elastomer, plasticizer etc., its surface is one layer and has semipermeable poly membrane structure.After this dressing contacts with wound fluid, exudate can be absorbed, and form a kind of gel, it is to avoid dressing is adhered with wound surface;Meanwhile, the semipermeable membrane structure on surface can allow oxygen and steam to swap, but have graininess foreign body such as dust and antibacterial to external world and have barrier.Advantage:
1, wound surface exudate and some noxious substances 2 can be absorbed, wound surface is kept to moisten, the bioactive substance of retention wound surface release itself, thering is provided outside an optimal microenvironment for wound healing, the process that can also make wound healing accelerates 3, there is debridement effect 4, form gel, the teleneuron that protection exposes, ease the pain, simultaneously, more do not result in property mechanical injuries 5 again during change dressings, there is autohension, easy to use 6, good compliance, user is comfortable on, and outward appearance hidden 7, intercept the intrusion of extraneous graininess foreign body such as dust and antibacterial, more change dressings number of times is few, thus alleviate the labor intensity of nursing staff because accelerating wound healing, expense can be saved.Shortcoming: 1, absorbability is not very strong, therefore for high exudative wound surface, absorbent properties 2, product cost be higher by 3, few patients there may be composition allergy to strengthen often to need to use other auxiliary dressing.Surgery medical dressing alginate dressing: alginate dressing is one of current state-of-the-art surgery medical dressing.Its main component of alginate dressing is alginate, is the natural polysaccharide carbohydrate extracted in Sargassum, for a kind of native cellulose.Alginate surgery medical dressing, the functional wound dressing of a kind of high-selenium corn performance being made up of alginate.After this medical films touches wound fluid, the gel of softness can be formed, provide preferable moist environment for wound healing, promote wound healing, alleviate wound pain.The mechanism of action: 1, safety non-toxic: alginate medical films is the natural polysaccharide carbohydrate extracted in Sargassum, for a kind of natural macromolecular material, to human body without any toxicity, can use safely.2, high-hygroscopicity: alginate medical films can absorb the 11 times of liquid being equivalent to own wt.3, hemostatic: alginate medical films contact wound exudate release Ca2+, the formation of thrombokinase can be promoted, accelerate blood clotting process.4, become colloidality: absorbing wound exudate, with sepage, the exchange of Na+/Ca2+ ion occurs, form one layer of stable network gel at wound surface.A microenvironment (micro-acid, anaerobic or hypoxia, appropriateness moisten) being beneficial to tissue growth is built for wound.5, promote wound healing: the wound climate that micro-acid, anaerobic or hypoxia, appropriateness moisten promotes growth factor release, stimulates cellular proliferation, improve regeneration capacity and the signaling of epidermis cell, promote wound healing.6, biocidal property: 1., good airproof performance, makes wound and extraneous antibacterial isolation;2., noxious bacteria be fixed on fibrous inside, effectively inhibit noxious bacteria breeding and reduce the chance that contacts with wound surface of antibacterial;3., moisten, the environmental benefits of micro-acid plays a role in neutrophilic granulocyte, strengthens local bactericidal ability, reduces infection rate 7, minimizing local pain: the water gel that surface is formed effectively protects nerve ending, it is to avoid environmental stimuli;It is difficult to and wound adhesion, easily removes, reduce wound pain.8, cicatrization is reduced: due to non-stimulated to wound surface, not damaged, so cicatrization is few.Advantage: 1, powerful and quickly absorb the ability 2 of transudate, form gel, can keep wound surface moistening and not glue wound surface, the teleneuron that protection exposes, and eases the pain 3, promotes wound healing;4, biodegradable, good environmental protection;5, cicatrization is reduced;Shortcoming: 1, most products does not possess autohension, need to assist dressing to be fixed 2, cost of a relatively high
Summary of the invention
For solving above-mentioned technical problem, the technical solution used in the present invention is as follows:
A kind of surgery medical dressing, uses sodium alginate fiber to make, has biodegradability and high-hydroscopicity.
The preparation method of described surgery medical dressing, it is characterised in that:
(1) the sodium alginate fiber 4 ~ 6wt% being discarded or recycled is taken, it is added thereto to sodium alginate fiber quality 2~the hyaluronate sodium of 3%, the organic acid soln regulation pH to 5.0~5.5 using mass fraction to be 30 ~ 40%, heat subsequently, design temperature is 60~65 DEG C, naturally cool to room temperature after keeping temperature 40~50min, filtrate is collected by filtration;
(2) filtrate of above-mentioned gained is put in baking oven, 1~3h it is dried at 70 ~ 90 DEG C, again dried filtrate is put in pulverizer and pulverize, cross 60 ~ 90 mesh sieves, by powder by solid-liquid mass ratio (1.5 ~ 2.5): (3 ~ 1) mix with water, and use the acetum regulation pH of mixed of 10 ~ 50wt% to 4.0~5.0, filter after standing acidification 1~3h, collect filtrate, filtrate is put in air-dry machine and air-dry, put into after Feng Ganing in pulverizer and pulverize, cross 100 ~ 240 mesh sieves, obtain acidifying sodium alginate powder;
(3) take 40 ~ 50 mesh olivines or acidifying sodium alginate powder that allochite prepares with step 2 mixes according to the mass ratio of 1 ~ 6:6 ~ 1, subsequently by solid-liquid mass ratio (0.3 ~ 1): (2 ~ 5) are immersed in the sodium alginate soln of 6 ~ 10wt%, filter after soaking 1~2h, collect filtrate to air-dry, obtain composite particles;
(4) above-mentioned composite particles is put in agitator, in agitator, order adds the carboxymethyl chitosan quaternary ammonium salt of 2~3wt% respectively, the dissolved ceratinase of 0.5~1.2wt% and the baicalin of 3~4wt% or curcumin, add the menthol solutions immersion mixture that mass fraction is 30 ~ 40%, stirring is until institute's additive is completely dissolved layered suspension, gained suspension is placed in microwave reactor, under the conditions of microwave radiation, regulation microwave irradiation power is 250W~600W, radiation temperature is 46 DEG C~86 DEG C, microwave reaction 40min~110min, by product in deionized water dialysis to neutral, collect product lyophilization, i.e. obtain required surgery medical dressing.
Organic acid is selected from tartaric acid, acetic acid, formic acid, succinic acid, oxalic acid, ethanedioic acid, caproic acid, maleic acid, citric acid or stearic acid.Described carboxymethyl chitosan quaternary ammonium salt is O-carboxymethyl-N-N-trimethyl chitosan TMC quaternary ammonium salt (CMTMC).Described lyophilization uses Vacuum Freezing & Drying Technology, and temperature is-25 ~ 35 DEG C.Wherein the molecular weight of carboxymethyl chitosan quaternary ammonium salt is 1.7 × 105~1.6 × 106, the substitution value of quaternary ammonium salt is 75 ~ 85%, and the substitution value of carboxymethyl is 50 ~ 60%.
Further, the preparation method of above-mentioned surgery medical dressing, obtained surgery medical dressing has layer structure.
Further, the preparation method of above-mentioned surgery medical dressing, obtained surgery medical dressing has high-hydroscopicity.
Further, the preparation method of above-mentioned surgery medical dressing, obtained surgery medical dressing has biodegradability.
Further, the preparation method of above-mentioned surgery medical dressing, obtained surgery medical dressing has anti-microbial property.
Further, the preparation method of above-mentioned surgery medical dressing, obtained surgery medical dressing has hemostasis and promotes the function of wound healing.
Compared with prior art, the invention have the advantages that
(1) present invention uses microwave irradiation can quickly obtain surgery medical dressing of good performance, and avoids the destruction of the composition such as chitosan derivatives, sodium alginate in manufacture process, it is ensured that antibiotic property, high-hydroscopicity and biodegradable.
(2) the surgery medical dressing that the present invention prepares combines the advantage of chitosan derivatives, sodium alginate, baicalin or curcumin, having possessed anti-microbial property and the heat stability of excellence, olivine or epidotic addition simultaneously makes composite form layer structure thus effective bacteria growing inhibiting and prevent wound infection.
(3) the surgery medical dressing that the present invention prepares overcomes general surgery medical dressing intensity difference, the problem of poor durability., and there is the most excellent water suction, moisturizing and water vapour permeability.
Detailed description of the invention
Embodiment 1:
(1) the sodium alginate fiber 4wt% being discarded or recycled is taken, it is added thereto to the hyaluronate sodium of sodium alginate fiber quality 3%, the organic acid soln regulation pH to 5.5 using mass fraction to be 30%, heat subsequently, design temperature is 65 DEG C, naturally cool to room temperature after keeping temperature 50min, filtrate is collected by filtration;
(2) filtrate of above-mentioned gained is put in baking oven, at 90 DEG C, it is dried 3h, more dried filtrate is put in pulverizer pulverizes, cross 60 mesh sieves, powder is mixed with water by solid-liquid mass ratio 1.5:3, and use the acetum regulation pH of mixed of 10wt% to 4.0, filter after standing acidification 3h, collect filtrate, filtrate is put in air-dry machine and air-dry, put into after Feng Ganing in pulverizer and pulverize, cross 240 mesh sieves, obtain acidifying sodium alginate powder;
(3) take 40 mesh olivines or acidifying sodium alginate powder that allochite prepares with step 2 mixes according to the mass ratio of 1:6, it is immersed in the sodium alginate soln of 10wt% by solid-liquid mass ratio 1:2 subsequently, filter after soaking 2h, collect filtrate and air-dry, obtain composite particles;
(4) above-mentioned composite particles is put in agitator, in agitator, order adds the carboxymethyl chitosan quaternary ammonium salt of 3wt% respectively, the dissolved ceratinase of 1.2wt% and the baicalin of 4wt% or curcumin, add the menthol solutions immersion mixture that mass fraction is 30%, stirring is until institute's additive is completely dissolved layered suspension, gained suspension is placed in microwave reactor, under the conditions of microwave radiation, regulation microwave irradiation power is 250W, radiation temperature is 86 DEG C, microwave reaction 110min, by product in deionized water dialysis to neutral, collect product lyophilization, i.e. obtain required surgery medical dressing.
Embodiment 2:
(1) the sodium alginate fiber 6wt% being discarded or recycled is taken, it is added thereto to the hyaluronate sodium of sodium alginate fiber quality 3%, the organic acid soln regulation pH to 5 using mass fraction to be 40%, heat subsequently, design temperature is 65 DEG C, naturally cool to room temperature after keeping temperature 40min, filtrate is collected by filtration;
(2) filtrate of above-mentioned gained is put in baking oven, at 70 DEG C, is dried 1h, more dried filtrate is put in pulverizer pulverizes, cross 90 mesh sieves, by powder by solid-liquid mass ratio 2.5:
1 mixes with water, and uses the acetum regulation pH of mixed of 50wt% to filter after standing acidification 3h to 4. 5, collects filtrate, filtrate is put in air-dry machine and air-dry, put in pulverizer and pulverize after air-drying, crosses 240 mesh sieves, obtain acidifying sodium alginate powder;
(3) take 40 mesh olivines or acidifying sodium alginate powder that allochite prepares with step 2 mixes according to the mass ratio of 1:6, it is immersed in the sodium alginate soln of 10wt% by solid-liquid mass ratio 0.3:2.5 subsequently, filter after soaking 1.2h, collect filtrate and air-dry, obtain composite particles;
(4) above-mentioned composite particles is put in agitator, in agitator, order adds the carboxymethyl chitosan quaternary ammonium salt of 3wt% respectively, the dissolved ceratinase of 1.2wt% and the baicalin of 3.4wt% or curcumin, add the menthol solutions immersion mixture that mass fraction is 34%, stirring is until institute's additive is completely dissolved layered suspension, gained suspension is placed in microwave reactor, under the conditions of microwave radiation, regulation microwave irradiation power is 550W, radiation temperature is 46 DEG C, microwave reaction 40min, by product in deionized water dialysis to neutral, collect product lyophilization, i.e. obtain required surgery medical dressing.
Comparative example 1:
The other the same as in Example 1, but microwave irradiation power is 800w, and radiation temperature is 90 DEG C, and the microwave reaction time is 120min.
Comparative example 2:
First discarded silkworm silk is taken, first with water, its surface is cleaned, being soaked in mass fraction again is in 5% hydrogen peroxide solution, it is added thereto to discarded silk quality 3% chitosan, the hydrochloric acid solution regulation pH to 5.5 using mass fraction to be 30%, heats subsequently, and design temperature is 65 DEG C, naturally cool to room temperature after keeping temperature 50min, filtrate is collected by filtration;The filtrate of gained is put in baking oven, at 90 DEG C, it is dried 3h, more dried filtrate is put in pulverizer pulverizes, cross 80 mesh sieves, powder is mixed with water by solid-to-liquid ratio 1:2, and the phosphoric acid solution regulation pH of mixed using mass fraction to be 40% is to 4.0, filters, collect filtrate after standing acidification 3h, filtrate is put in air-dry machine and air-dry, put into after Feng Ganing in pulverizer and pulverize, cross 200 mesh sieves, obtain acidifying Silk Powder;Take expanded vermiculite and put in calcining furnace, room temperature is cooled to the furnace after calcining 3h at 600 DEG C, taking-up is put in pulverizer and is pulverized, cross 50 mesh sieves, obtain carrier granular, use ensilage dump blower to be blown in carrier granular by the Silk Powder after above-mentioned acidifying, subsequently carrier granular is immersed in the sodium alginate soln that mass fraction is 5% by solid-to-liquid ratio 1:5, filter after soaking 2h, collect filtrate and air-dry, obtain parcel carrier granular;By the parcel carrier granular of gained and cattle feedstuff, rear cattle after 1:2 mixes in mass ratio, collect cattle manure and put in container, after addition distilled water floods cattle manure 5cm in container, to filter after 300r/min stirring 15min, collect the carrier granular in filtrate;The carrier granular of collection is put in glass container, the curcumin of the carrier granular quality 1.2% of the chitosan of carrier granular quality 3% of collection, collection and the baicalin of the carrier granular quality 4% of collection is added respectively in glass container, add the alcohol solution dipping mixture that mass fraction is 50%, stirring is until institute's additive is completely dissolved, move it in microwave reactor, under 600MHz, react 30min be placed under ultra-vioket radiation, graft modification 2h, modified filtration, obtains filtrate;Collecting after the filtrate after filtering air-dries puts in ultrasonator, crosses 200 mesh sieves, collect the powder of the gained that sieves, i.e. can get composite antibacterial fibre after vibration 3h.The described composite antibacterial fibre obtained employing nonwoven techniques is made surgery medical dressing.
Comparative example 3:
0.2g carboxymethyl chitosan quaternary ammonium salt/organic montmorillonite nano composite material is dissolved in deionized water the solution being made into 20mg/mL, used in it, the weight average molecular weight of carboxymethyl chitosan quaternary ammonium salt is 1.2 × 106, the substitution value of carboxymethyl is 70%, the substitution value 85% of quaternary ammonium salt, 0.4g sodium alginate is dissolved in deionized water the solution being made into 40mg/mL, under conditions of stirring, it is transferred to mould after carboxymethyl chitosan quaternary ammonium salt/organic montmorillonite nano composite material solution and sodium alginate soln uniformly being mixed, now carboxymethyl chitosan quaternary ammonium salt/organic montmorillonite nano composite material is about 1:2 with the weight ratio of sodium alginate, it is soaked in 4wt% calcium chloride solution, reaction 3h postlyophilization, i.e. obtain Medical composite dressing.
Surgery medical dressing embodiment 1-2 and the comparative example 1-3 that there is provided the present invention measure water absorbent rate, rate of water absorption, liquid-keeping property, moisture permeability according to tests below method.The value measured is to carry out the meansigma methods of 3 times respectively, and its testing result is as shown in table 1.
Water absorbent rate:
In rustless steel container, put into the normal saline (0.9%NaCl) of about 10ml, test material is cut into
The test film of 4*4cm, preserves 8 hours in being sealed in container, and putting into the test film weight before container is m1 (g), and the test film weight taken out after 8 hours is m2 (g), water absorbent rate Q=(m2-m1)/m1.
Rate of water absorption:
Drip the normal saline (0.9%NaCl) of 500 μ l on test film surface, measures the time that liquid is completely absorbed.
Liquid-keeping property:
In rustless steel container, put into the normal saline (0.9%NaCl) of L1 (ml), test material is cut into
The test film of 7cm*10cm*0.1cm, preserves 8 hours in being sealed in container, after taking out test film, measures amount L2 (ml) of residue normal saline, liquid-keeping property=(L2-L1)/(7*10*0.1) * 103 (L/m3).
Moisture permeability:
Measure according to the cup type method of GB 1037-88.In glass container, put into about 10ml rectification water, test material is cut into the circular test film of a diameter of 80mm, test film is covered the opening at glass container, with the thin film that paraffin does, glass container is sealed, measure weight W0 now.Then, after standing 24 hours in the Constant Temperature and Humidity Chambers of 40 DEG C-75%, accurately measuring weight W1 after letting cool, moisture permeability=(W1-W0) * 104/A (g/m2/24h), wherein A is the area (cm2) of glass container peristome.
Table 1 testing result
Water absorbent rate | Rate of water absorption (s) | Liquid-keeping property L/m3 | Moisture permeability g/m2/24h | |
Embodiment 1 | 23 | 7 | 15000 | 1432 |
Embodiment 2 | 28 | 9 | 12000 | 1416 |
Comparative example 1 | 18 | 24 | 10000 | 980 |
Comparative example 2 | 8 | 653 | 7900 | 366 |
Comparative example 3 | 10 | 126 | 9800 | 478 |
Claims (7)
1. a surgical medical dressing, it is characterised in that: use sodium alginate fiber to make, there is biological degradability and high-hydroscopicity.
2. the preparation method of a surgical medical dressing as claimed in claim 1, it is characterised in that:
(1) the sodium alginate fiber 4 ~ 6wt% being discarded or recycled is taken, it is added thereto to sodium alginate fiber quality 2~the hyaluronate sodium of 3%, the organic acid soln regulation pH to 5.0~5.5 using mass fraction to be 30 ~ 40%, heat subsequently, design temperature is 60~65 DEG C, naturally cool to room temperature after keeping temperature 40~50min, filtrate is collected by filtration;
(2) filtrate of above-mentioned gained is put in baking oven, 1~3h it is dried at 70 ~ 90 DEG C, again dried filtrate is put in pulverizer and pulverize, cross 60 ~ 90 mesh sieves, by powder by solid-liquid mass ratio (1.5 ~ 2.5): (3 ~ 1) mix with water, and use the acetum regulation pH of mixed of 10 ~ 50wt% to 4.0~5.0, filter after standing acidification 1~3h, collect filtrate, filtrate is put in air-dry machine and air-dry, put into after Feng Ganing in pulverizer and pulverize, cross 100 ~ 240 mesh sieves, obtain acidifying sodium alginate powder;
(3) take 40 ~ 50 mesh olivines or acidifying sodium alginate powder that allochite prepares with step 2 mixes according to the mass ratio of 1 ~ 6:6 ~ 1, subsequently by solid-liquid mass ratio (0.3 ~ 1): (2 ~ 5) are immersed in the sodium alginate soln of 6 ~ 10wt%, filter after soaking 1~2h, collect filtrate to air-dry, obtain composite particles;
(4) above-mentioned composite particles is put in agitator, in agitator, order adds the carboxymethyl chitosan quaternary ammonium salt of 2~3wt% respectively, the dissolved ceratinase of 0.5~1.2wt% and the baicalin of 3~4wt% or curcumin, add the menthol solutions immersion mixture that mass fraction is 30 ~ 40%, stirring is until institute's additive is completely dissolved layered suspension, gained suspension is placed in microwave reactor, under the conditions of microwave radiation, regulation microwave irradiation power is 250W~600W, radiation temperature is 46 DEG C~86 DEG C, microwave reaction 40min~110min, by product in deionized water dialysis to neutral, collect product lyophilization, i.e. obtain required surgery medical dressing.
3. preparation method as claimed in claim 2, it is characterised in that organic acid is selected from tartaric acid, acetic acid, formic acid, succinic acid, oxalic acid, ethanedioic acid, caproic acid, maleic acid, citric acid or stearic acid.
4. preparation method as claimed in claim 2, it is characterised in that: described carboxymethyl chitosan quaternary ammonium salt is O-carboxymethyl-N-N-trimethyl chitosan TMC quaternary ammonium salt (CMTMC).
5. preparation method as claimed in claim 2, it is characterised in that: the surgery medical dressing obtained has layer structure.
6. preparation method as claimed in claim 2, it is characterised in that: the surgery medical dressing obtained has biodegradability.
7. method as claimed in claim 2, it is characterised in that: described lyophilization uses Vacuum Freezing & Drying Technology, and temperature is-25 ~ 35 DEG C.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101230150A (en) * | 2008-02-27 | 2008-07-30 | 中国科学院化学研究所 | Method for preparing pure sodium alginate nano fiber membrane material |
CN101897990A (en) * | 2010-07-06 | 2010-12-01 | 大连理工大学 | Dressing composition used for inhibiting scars and accelerating wound healing and application thereof |
CN104069536A (en) * | 2014-07-11 | 2014-10-01 | 江苏开源康达医疗器械有限公司 | Method for preparing sodium alginate-chitosan nano-grade medical dressing |
-
2016
- 2016-08-08 CN CN201610641729.6A patent/CN105999367B/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101230150A (en) * | 2008-02-27 | 2008-07-30 | 中国科学院化学研究所 | Method for preparing pure sodium alginate nano fiber membrane material |
CN101897990A (en) * | 2010-07-06 | 2010-12-01 | 大连理工大学 | Dressing composition used for inhibiting scars and accelerating wound healing and application thereof |
CN104069536A (en) * | 2014-07-11 | 2014-10-01 | 江苏开源康达医疗器械有限公司 | Method for preparing sodium alginate-chitosan nano-grade medical dressing |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN106729942A (en) * | 2017-03-15 | 2017-05-31 | 张天奇 | A kind of medical dressing and preparation method thereof |
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