CN105999233A - 一种治疗女性不孕不育的药物及其制备方法 - Google Patents
一种治疗女性不孕不育的药物及其制备方法 Download PDFInfo
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- CN105999233A CN105999233A CN201610290589.2A CN201610290589A CN105999233A CN 105999233 A CN105999233 A CN 105999233A CN 201610290589 A CN201610290589 A CN 201610290589A CN 105999233 A CN105999233 A CN 105999233A
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Abstract
本发明属于中药技术领域,具体涉及一种治疗女性不孕不育的药物及其制备方法。所述药物包括山药、黄精、枸杞子、阿胶、佛手、红枣、槐米、桑葚、龙眼肉、覆盆子、当归、桑叶、西红花、干鱼膘、氨基酸、维生素、β‑胡萝卜素、叶酸、泛酸钙、硒酵母、葡萄糖酸锌、富马酸亚铁、氧化镁、L‑乳酸钙、鱼胶原蛋白、葡萄籽提取物。本发明采用低温提取,浓缩等技术,将原料依次混合,配方合理,并将多种药物及营养物质合理配比,利用各种组分相互间的协同作用,提高疗效,以适应复杂病情的治疗要求,能够有效治疗女性不孕不育,进行优生优育。
Description
技术领域
本发明属于中药技术领域,具体涉及一种治疗女性不孕不育的药物及其制备方法。
背景技术
近年来,随着社会的发展,生活节奏的加快,现代夫妻不孕不育的程度大幅上升,其中,女方因素约为60%左右,对于女性不孕不育的原因分类有很多种,比如性疾,糖尿病等疾病因素,个人心理因素;环境和工业毒物增加,也可以影响男女双方的生殖系统,此外,长期处于高强度辐射下可造成不孕不育。女性不孕不育的程度大幅上升已经到了一种前所未有的地步,显然已经成为了一种现代病,给很多家庭带来了严重的困扰和打击。
西医治疗不孕不育目前最常用的是“试管婴儿技术”,成功率只达到了50-60%,且花费高及不确定的副作用多,因此找到一种既安全又有效的治疗女性不孕不育的药物,具有重要意义。
发明内容
为了解决现有技术存在的上述问题,本发明提供了一种治疗女性不孕不育的药物及其制备方法。
本发明所采用的技术方案为:
一种治疗女性不孕不育的药物,包括如下重量份的原料制备而成:10-30份山药、5-20份黄精、3-15份枸杞子、2-12份阿胶、2-12份佛手、0.5-8份红枣、2-12份槐米、5-20份桑葚、5-20份龙眼肉、0.1-1份覆盆子、3-15份当归、2-12份桑叶、1-5份西红花、10-30份干鱼膘、1-10份氨基酸、0.01-0.05份维生素、0.0001-0.002份β-胡萝卜素、0.00005-0.0005份叶酸、0.0005-0.005份泛酸钙、0.00025-0.005份硒酵母、0.01-0.1份葡萄糖酸锌、0.005-0.03份富马酸亚铁、0.01-0.1份氧化镁、0.5-5份L-乳酸钙、1-12份鱼胶原蛋白、0.3-3份葡萄籽提取物。
进一步的,所述治疗女性不孕不育的药物,包括如下重量份的原料制备而成:15-25份山药、8-15份黄精、5-12份枸杞子、3-10份阿胶、3-10份佛手、0.8-3份红枣、3-10份槐米、8-15份桑葚、8-15份龙眼肉、0.2-0.8份覆盆子、5-12份当归、3-10份桑叶、1-3份西红花、15-25份干鱼膘、2-8份氨基酸、0.015-0.03份维生素、0.0005-0.0015份β-胡萝卜素、0.00008-0.0003份叶酸、0.001-0.003份泛酸钙、0.0001-0.003份硒酵母、0.02-0.05份葡萄糖酸锌、0.01-0.02份富马酸亚铁、0.05-0.08份氧化镁、1-3份L-乳酸钙、3-10份鱼胶原蛋白、0.5-2份葡萄籽提取物。
进一步的,所述治疗女性不孕不育的药物,包括如下重量份的原料制备而成:20份山药、10份黄精、8份枸杞子、6份阿胶、6.67份佛手、1份红枣、6.67份槐米、10份桑葚、10份龙眼肉、0.4份覆盆子、8份当归、6.6份桑叶、2份西红花、20份干鱼膘、3.5份氨基酸、0.02份维生素、0.001份β-胡萝卜素、0.0001份叶酸、0.0015份泛酸钙、0.00125份硒酵母、0.026份葡萄糖酸锌、0.012份富马酸亚铁、0.066份氧化镁、1.5份L-乳酸钙、6.93669份鱼胶原蛋白、0.8份葡萄籽提取物。
进一步的,所述维生素为除叶酸以外的维生素;所述维生素包括维生素A、维生素B1、维生素B2、维生素B3、维生素B6、维生素B12、维生素C、维生素D、维生素E中的一种或至少两种的混合物。
进一步的,所述的氨基酸包括精氨酸、DL-蛋氨酸、半胱氨酸中的一种或至少两种的混合物。
进一步的,所述原料还包括5-20重量份的调味剂,所述调味剂为葡萄糖、果糖、蔗糖、麦芽糖、淀粉糖、乳糖、木糖醇和蜂蜜中的一种或至少两种的组合。
一种上述的治疗女性不孕不育的药物的制备方法,包括如下步骤:
步骤1、将山药、黄精、枸杞、阿胶、佛手、槐米、桑葚、龙眼肉、当归、桑叶、西红花、干鱼膘分别进行干燥、粉碎后,进行混合,得到第一粉末混合物;
步骤2、向所述第一粉末混合物中加入乙醇,浸泡20-30min,并在60-80℃回流提取2-8小时,之后回收乙醇,得到提取液;将所述提取液进行过滤、浓缩,干燥,得到第二粉末混合物;
步骤3、将红枣、泛酸钙、硒酵母、葡萄糖酸锌、富马酸亚铁、氧化镁、L-乳酸钙、鱼胶原蛋白、葡萄籽提取物分别进行干燥、粉碎后,进行混合,得到第三粉末混合物;
步骤4、将所述第二粉末混合物与所述第三粉末混合物进行混合后,依次加入氨基酸、维生素、β-胡萝卜素、叶酸进行充分混合,得到所述治疗女性不孕不育的药物。
所述治疗女性不孕不育的药物为胶囊或粉剂,治疗时,每日两次,每次10-15g。
进一步的,所述第一粉末混合物的粒径为150-300目;所述第三粉末混合物的粒径为150-300目。
步骤2中,所述乙醇的体积浓度为60-80%。所述第一粉末混合物的质量与所述乙醇的体积比为1:3-8g/ml。当第一粉末混合物的使用量为1g时,乙醇的加入量为3-8ml。
为了便于了解本发明提供的治疗女性不孕不育的药物,下面对所述的原料及药效作进一步阐述。
山药为薯蓣科植物薯蓣(DioscoreaoppositaThunb.)的干燥根茎。具有补脾养胃,生津益肺,补肾涩精之效。用于脾虚食少,久泻不止,肺虚喘咳,肾虚遗精,带下,尿频,虚热消渴。
黄精为百合科植物滇黄精(PolygonatumkingianumColl.etHemsl.)、黄精(PolygonatumsibiricumRed.)或多花黄精(PolygonatumcyrtonemaHua)的干燥根茎。具有补气养阴,健脾,润肺,益肾之效。用于脾胃气虚,体倦乏力,胃阴不足,口干食少,肺虚燥咳,劳嗽咳血,精血不足,腰膝酸软,须发早白,内热消渴。
枸杞为茄科植物宁夏枸杞(LyciumbarbarumL.)的干燥成熟果实。具有滋补肝肾,益精明目之效。用于虚劳精亏,腰膝酸痛,眩晕耳鸣,阳萎遗精,内热消渴,血虚萎黄,目昏不明。
阿胶为马科动物驴EquusasinusL.的干燥皮或鲜皮经煎煮、浓缩制成的固体胶。能够补血滋阴,润燥,止血。用于血虚萎黄,眩晕心悸,肌痿无力,心烦不眠,虚风内动,肺燥咳嗽,劳嗽咯血,吐血尿血,便血崩漏,妊娠胎漏。
佛手为芸香科植物佛手CitrusmedicaL.var.sarcodactylisSwingle的干燥果实。能够疏肝理气,和胃止痛,燥湿化痰。用于肝胃气滞,胸胁胀痛,胃脘痞满,食少呕吐,咳嗽痰多。
槐米为豆科植物槐(Sophora japonica L.)的干燥花蕾及花。具有抗炎、抗病毒、祛痰、止咳等作用。
桑葚为桑树的成熟果实,具有滋阴补血,生津润燥、补肝益肾、补血养颜、改善生殖亚健康、增强免疫功能的作用。
龙眼肉为无患子科植物龙眼DimocarpuslonganLour.的假种皮。能够补益心脾,养血安神。用于气血不足,心悸怔忡,健忘失眠,血虚萎黄。
当归为伞形科植物当归Angelicasinensis(Oliv.)Diels.的干燥根。补血活血,调经止痛,润肠通便。用于血虚萎黄,眩晕心悸,月经不调,经闭痛经,虚寒腹痛,风湿痹痛,跌扑损伤,痈疽疮疡,肠燥便秘。酒当归活血通经。用于经闭痛经,风湿痹痛,跌扑损伤。
桑叶为桑科植物桑MorusalbaL.的干燥叶。具有疏散风热,清肺润燥,清肝明目之效。用于风热感冒,肺热燥咳,头晕头痛,目赤昏花。
西红花为鸢尾科植物番红花CrocussativusL的干燥柱头。具有活血化瘀,凉血解毒,解郁安神之效。用于经闭瘕瘕,产后瘀阻,温毒发斑,忧郁痞闷,惊悸发狂。
干鱼膘俗称鱼泡,其主要成分为高级胶原蛋白、黏多糖,并含有多种维生素及钙、锌、铁、硒等多种微量元素。干鱼鳔中含有大量胶汁,又具有活血、补血、止血、御寒、祛湿等功效,所以能提高机体免疫力。
红枣,又名大枣。特点是维生素含量非常高,有“天然维生素丸”的美誉,具有滋阴补阳,健脾和胃、益气补血、袪风之功效。红枣具有较强的补养作用,能提高人体免疫功能,增强抗病能力。
泛酸钙是辅酶A的成分,参与碳水化合物、脂肪和蛋白质的代谢作用,临床用于治疗维生素B缺乏症,周围神经炎,手术后肠绞痛。参与蛋白质、脂肪、糖在体内的新陈代谢。
硒是人体必需的微量元素,当硒缺乏的时候,就很容易导致人体免疫能力下降,威胁人类健康和生命的四十多种疾病都与人体缺硒有关,如癌症、心血管病、肝病、白内障、胰脏疾病、糖尿病、生殖系统疾病等症状。硒酵母用于防治硒缺乏引起的疾病。
葡萄糖酸锌为补锌药,锌存在于众多的酶系中,如碳酸酐酶,呼吸酶,乳酸脱氢酸,超氧化物歧化酶,碱性磷酸酶,DNA和RNA聚中酶等中,为核酸,蛋白质,碳水化合物的合成和维生素A的利用所必需。锌具有促进生长发育,改善味觉的作用。锌缺乏时出现味觉,嗅觉差,厌食,生长与智力发育低于正常。
铁元素也是构成人体的必不可少的元素之一。富马酸亚铁常用于治疗缺铁性贫血,提高抗应激能力和抗病能力,与各种营养物质、抗生素相容性好,具有协同作用。能有效避免添加无机铁对维生素等活性物质的破坏。
镁是参与生物体正常生命活动及新陈代谢过程必不可少的元素,镁离子是人体细胞内的主要阳离子,是体内多种细胞基本生化反应的必需物质。氧化镁常用于镁元素的补充剂。
L-乳酸钙是一种很好的食品钙强化剂,吸收效果比无机钙好。用于防治钙缺乏症如手足搐搦症、骨发育不全、佝偻病,以及结核病、妊娠和哺乳期妇女的钙盐补充。
鱼胶原蛋白属于胶原蛋白,胶原蛋白是人体蛋白的重要组成成分之一,它可以补充皮肤各层所需的营养,使皮肤中胶原活性增强,有滋润皮肤,延缓衰老、美容、消皱、养发等功效。胶原蛋白广泛地存在于人体的皮肤、骨骼、肌肉、软骨、关节、头发组织中,起着支撑、修复、保护的三重抗衰老作用。
葡萄籽提取物是从天然葡萄籽中提取的有效活性营养成份配以维生素E等主要原料精制而成的营养食品。能有效清除人体内多余的自由基,具有超强的延缓衰老和增强免疫力的作用。能够抗氧化、抗过敏、抗疲劳、增强体质、改善亚健康状态、延缓衰老、改善烦躁易怒、头昏乏力、记忆力减退等症状。
氨基酸是构成生物体蛋白质并同生命活动有关的最基本的物质,是在生物体内构成蛋白质分子的基本单位,与生物的生命活动有着密切的关系。它在抗体内具有特殊的生理功能,是生物体内不可缺少的营养成分之一。
维生素是人和动物为维持正常的生理功能而必须从食物中获得的一类微量有机物质,在人体生长、代谢、发育过程中发挥着重要的作用。
叶酸也叫维生素B9,是一种水溶性维生素。具有促进骨髓中幼细胞成熟的作用,人类如缺乏叶酸可引起巨红细胞性贫血以及白细胞减少症,对孕妇尤其重要。
β-胡萝卜素是类胡萝卜素之一,是一种抗氧化剂,具有解毒作用,是维护人体健康不可缺少的营养素,在抗癌、预防心血管疾病、白内障及抗氧化上有显著的功能,并进而防止老化和衰老引起的多种退化性疾病。
本发明的有益效果为:本发明提供的治疗女性不孕不育的药物采用山药、黄精、红枣、枸杞、阿胶、佛手、槐米、桑葚、龙眼肉、当归、桑叶、西红花、干鱼膘等药材进行合理配比,共同起到滋阴补肾、补血益气、增强免疫力的功效;同时添加泛酸钙、L-乳酸钙预防钙缺乏,补充硒酵母、β-胡萝卜素、鱼胶原蛋白、葡萄籽提取物等物质以增强人体免疫力,延缓细胞老化;并以葡萄糖酸锌、富马酸亚铁和氧化镁补充镁、锌和铁等人体必要元素;最后添加氨基酸、维生素等人体不可缺少的营养物质,并补充叶酸,预防新生儿缺陷。本发明提供的治疗女性不孕不育的药物,仅采用低温提取,浓缩等技术,将原料依次混合,配方合理,并将多种药物及营养物质合理配比,利用各种组分相互间的协同作用,提高疗效,以适应复杂病情的治疗要求,能够有效治疗女性不孕不育,进行优生优育。
具体实施方式
实施例1
一种治疗女性不孕不育的药物,包括如下重量份的原料制备而成:10份山药、5份黄精、3份枸杞子、2份阿胶、2份佛手、0.5份红枣、2份槐米、5份桑葚、5份龙眼肉、0.1份覆盆子、3份当归、2份桑叶、1份西红花、10-30份干鱼膘、1份氨基酸、0.01份维生素、0.0001份β-胡萝卜素、0.00005份叶酸、0.0005份泛酸钙、0.00025份硒酵母、0.01份葡萄糖酸锌、0.005份富马酸亚铁、0.01份氧化镁、0.5份L-乳酸钙、1份鱼胶原蛋白、0.3份葡萄籽提取物和5份蜂蜜。
所述维生素包括维生素A、维生素B1、维生素B2、维生素B3、维生素B6、维生素B12、维生素C、维生素D和维生素E。所述的氨基酸包括精氨酸、DL-蛋氨酸和半胱氨酸。
所述治疗女性不孕不育的药物的制备方法,包括如下步骤:
步骤1、将山药、黄精、枸杞、阿胶、佛手、槐米、桑葚、龙眼肉、当归、桑叶、西红花、干鱼膘分别进行干燥、粉碎后,进行混合,得到第一粉末混合物;第一粉末混合物的粒径为150目。
步骤2、向所述第一粉末混合物中加入乙醇,浸泡20min,并在60℃回流提取2小时,之后回收乙醇,得到提取液;将所述提取液进行过滤、浓缩,干燥,得到第二粉末混合物;所述乙醇的体积浓度为60%;所述第一粉末混合物的质量与所述乙醇的体积比为1:3g/ml。
步骤3、将红枣、泛酸钙、硒酵母、葡萄糖酸锌、富马酸亚铁、氧化镁、L-乳酸钙、鱼胶原蛋白、葡萄籽提取物分别进行干燥、粉碎后,进行混合,得到第三粉末混合物;所述第三粉末混合物的粒径为150目。
步骤4、将所述第二粉末混合物与所述第三粉末混合物进行混合后,依次加入氨基酸、维生素、β-胡萝卜素、叶酸进行充分混合,得到所述治疗女性不孕不育的药物。
实施例2
一种治疗女性不孕不育的药物,包括如下重量份的原料制备而成:30份山药、20份黄精、15份枸杞子、12份阿胶、12份佛手、8份红枣、12份槐米、20份桑葚、20份龙眼肉、1份覆盆子、15份当归、12份桑叶、5份西红花、30份干鱼膘、10份氨基酸、0.05份维生素、0.002份β-胡萝卜素、0.0005份叶酸、0.005份泛酸钙、0.005份硒酵母、0.1份葡萄糖酸锌、0.03份富马酸亚铁、0.1份氧化镁、5份L-乳酸钙、12份鱼胶原蛋白、3份葡萄籽提取物、15份葡萄糖和5份木糖醇。
所述维生素包括维生素A、维生素B1、维生素B2、维生素B3、维生素B6、维生素B12、维生素C、维生素D和维生素E。所述的氨基酸包括精氨酸、DL-蛋氨酸和半胱氨酸。
所述治疗女性不孕不育的药物的制备方法,包括如下步骤:
步骤1、将山药、黄精、枸杞、阿胶、佛手、槐米、桑葚、龙眼肉、当归、桑叶、西红花、干鱼膘分别进行干燥、粉碎后,进行混合,得到第一粉末混合物;第一粉末混合物的粒径为300目。
步骤2、向所述第一粉末混合物中加入乙醇,浸泡30min,并在80℃回流提取8小时,之后回收乙醇,得到提取液;将所述提取液进行过滤、浓缩,干燥,得到第二粉末混合物;所述乙醇的体积浓度为80%;所述第一粉末混合物的质量与所述乙醇的体积比为1:8g/ml。
步骤3、将红枣、泛酸钙、硒酵母、葡萄糖酸锌、富马酸亚铁、氧化镁、L-乳酸钙、鱼胶原蛋白、葡萄籽提取物分别进行干燥、粉碎后,进行混合,得到第三粉末混合物;所述第三粉末混合物的粒径为300目。
步骤4、将所述第二粉末混合物与所述第三粉末混合物进行混合后,依次加入氨基酸、维生素、β-胡萝卜素、叶酸进行充分混合,得到所述治疗女性不孕不育的药物。
实施例3
一种治疗女性不孕不育的药物,包括如下重量份的原料制备而成:15份山药、8份黄精、5份枸杞子、3份阿胶、3份佛手、0.8份红枣、3份槐米、8-15份桑葚、8份龙眼肉、0.2份覆盆子、5份当归、3份桑叶、1份西红花、15份干鱼膘、2份氨基酸、0.015份维生素、0.0005份β-胡萝卜素、0.00008份叶酸、0.001份泛酸钙、0.0001份硒酵母、0.02份葡萄糖酸锌、0.01份富马酸亚铁、0.05份氧化镁、1份L-乳酸钙、3份鱼胶原蛋白、0.5份葡萄籽提取物和10份果糖。
所述维生素包括维生素A、维生素B1、维生素B2、维生素B3、维生素B6、维生素B12、维生素C、维生素D和维生素E。所述的氨基酸包括精氨酸、DL-蛋氨酸和半胱氨酸。
所述治疗女性不孕不育的药物的制备方法,包括如下步骤:
步骤1、将山药、黄精、枸杞、阿胶、佛手、槐米、桑葚、龙眼肉、当归、桑叶、西红花、干鱼膘分别进行干燥、粉碎后,进行混合,得到第一粉末混合物;第一粉末混合物的粒径为200目。
步骤2、向所述第一粉末混合物中加入乙醇,浸泡25min,并在78℃回流提取5小时,之后回收乙醇,得到提取液;将所述提取液进行过滤、浓缩,干燥,得到第二粉末混合物;所述乙醇的体积浓度为75%;所述第一粉末混合物的质量与所述乙醇的体积比为1:5g/ml。
步骤3、将红枣、泛酸钙、硒酵母、葡萄糖酸锌、富马酸亚铁、氧化镁、L-乳酸钙、鱼胶原蛋白、葡萄籽提取物分别进行干燥、粉碎后,进行混合,得到第三粉末混合物;所述第三粉末混合物的粒径为200目。
步骤4、将所述第二粉末混合物与所述第三粉末混合物进行混合后,依次加入氨基酸、维生素、β-胡萝卜素、叶酸进行充分混合,得到所述治疗女性不孕不育的药物。
实施例4
一种治疗女性不孕不育的药物,包括如下重量份的原料制备而成:25份山药、15份黄精、12份枸杞子、10份阿胶、10份佛手、3份红枣、10份槐米、15份桑葚、15份龙眼肉、0.8份覆盆子、12份当归、10份桑叶、3份西红花、25份干鱼膘、8份氨基酸、0.03份维生素、0.0015份β-胡萝卜素、0.0003份叶酸、0.003份泛酸钙、0.003份硒酵母、0.05份葡萄糖酸锌、0.02份富马酸亚铁、0.08份氧化镁、3份L-乳酸钙、10份鱼胶原蛋白、2份葡萄籽提取物和12份乳糖。
所述维生素包括维生素A、维生素B1、维生素B2、维生素B3、维生素B6、维生素B12、维生素C、维生素D和维生素E。所述的氨基酸包括精氨酸、DL-蛋氨酸和半胱氨酸。
所述治疗女性不孕不育的药物的制备方法,包括如下步骤:
步骤1、将山药、黄精、枸杞、阿胶、佛手、槐米、桑葚、龙眼肉、当归、桑叶、西红花、干鱼膘分别进行干燥、粉碎后,进行混合,得到第一粉末混合物;第一粉末混合物的粒径为250目。
步骤2、向所述第一粉末混合物中加入乙醇,浸泡25min,并在70℃回流提取6小时,之后回收乙醇,得到提取液;将所述提取液进行过滤、浓缩,干燥,得到第二粉末混合物;所述乙醇的体积浓度为70%;所述第一粉末混合物的质量与所述乙醇的体积比为1:7g/ml。
步骤3、将红枣、泛酸钙、硒酵母、葡萄糖酸锌、富马酸亚铁、氧化镁、L-乳酸钙、鱼胶原蛋白、葡萄籽提取物分别进行干燥、粉碎后,进行混合,得到第三粉末混合物;所述第三粉末混合物的粒径为250目。
步骤4、将所述第二粉末混合物与所述第三粉末混合物进行混合后,依次加入氨基酸、维生素、β-胡萝卜素、叶酸进行充分混合,得到所述治疗女性不孕不育的药物。
实施例5
一种治疗女性不孕不育的药物,包括如下重量份的原料制备而成:20份山药、10份黄精、8份枸杞子、6份阿胶、6.67份佛手、1份红枣、6.67份槐米、10份桑葚、10份龙眼肉、0.4份覆盆子、8份当归、6.6份桑叶、2份西红花、20份干鱼膘、3.5份氨基酸、0.02份维生素、0.001份β-胡萝卜素、0.0001份叶酸、0.0015份泛酸钙、0.00125份硒酵母、0.026份葡萄糖酸锌、0.012份富马酸亚铁、0.066份氧化镁、1.5份L-乳酸钙、6.93669份鱼胶原蛋白、0.8份葡萄籽提取物、3份果糖和3份蜂蜜。
所述维生素包括维生素A、维生素B1、维生素B2、维生素B3、维生素B6、维生素B12、维生素C、维生素D和维生素E。所述的氨基酸包括精氨酸、DL-蛋氨酸和半胱氨酸。
所述治疗女性不孕不育的药物的制备方法,包括如下步骤:
步骤1、将山药、黄精、枸杞、阿胶、佛手、槐米、桑葚、龙眼肉、当归、桑叶、西红花、干鱼膘分别进行干燥、粉碎后,进行混合,得到第一粉末混合物;第一粉末混合物的粒径为200目。
步骤2、向所述第一粉末混合物中加入乙醇,浸泡20min,并在75℃回流提取2-8小时,之后回收乙醇,得到提取液;将所述提取液进行过滤、浓缩,干燥,得到第二粉末混合物;所述乙醇的体积浓度为65%;所述第一粉末混合物的质量与所述乙醇的体积比为1:4g/ml。
步骤3、将红枣、泛酸钙、硒酵母、葡萄糖酸锌、富马酸亚铁、氧化镁、L-乳酸钙、鱼胶原蛋白、葡萄籽提取物分别进行干燥、粉碎后,进行混合,得到第三粉末混合物;所述第三粉末混合物的粒径为200目。
步骤4、将所述第二粉末混合物与所述第三粉末混合物进行混合后,依次加入氨基酸、维生素、β-胡萝卜素、叶酸进行充分混合,得到所述治疗女性不孕不育的药物。
上述实施例中1份的重量为1g。
选取500例不孕不育患者病历,其中排除男方因素,服用本发明提供的治疗女性不孕不育的药物,每日两次,每次10-15g,治疗期间停止服用其他药物,禁烟酒、避免其他外界因素如工业污染、放射线及电磁波的影响。
服用后3-6个月,女方怀孕为显效;
服用后6-12个月,女方怀孕为有效;
服用后12个月,女方依旧不孕为无效。
服用后,观察患者情况,无效3%、有效27%,显效70%,即本发明提供的治疗女性不孕不育的药物有效率为97%,本发明提供的治疗女性不孕不育的药物,仅采用低温提取,浓缩,将原料依次混合,配方合理,并将多种药物及营养物质合理配比,利用各种组分相互间的协同作用,提高疗效,以适应复杂病情的治疗要求,能够有效治疗女性不孕不育,进行优生优育。
上述500例患者中的典型案例,如下所述。
效果例1
李某,女,30岁,结婚3年未能怀孕,服用本发明实施例3提供的治疗女性不孕不育的药物,8个月后,进行检查,确认怀孕。
效果例2
孙某,女,32岁,结婚5年未能怀孕,服用本发明实施例5提供的治疗女性不孕不育的药物,12个月后,进行检查,确认怀孕。
效果例2
王某某,女,28岁,结婚2年未能怀孕,服用本发明实施例4提供的治疗女性不孕不育的药物,5个月后,进行检查,确认怀孕。
本发明不局限于上述最佳实施方式,任何人在本发明的启示下都可得出其他各种形式的产品,但不论在其配方或组份上作任何变化,凡是具有与本申请相同或相近似的技术方案,均落在本发明的保护范围之内。
Claims (10)
1.一种治疗女性不孕不育的药物,其特征在于:包括如下重量份的原料制备而成:10-30份山药、5-20份黄精、3-15份枸杞子、2-12份阿胶、2-12份佛手、0.5-8份红枣、2-12份槐米、5-20份桑葚、5-20份龙眼肉、0.1-1份覆盆子、3-15份当归、2-12份桑叶、1-5份西红花、10-30份干鱼膘、1-10份氨基酸、0.01-0.05份维生素、0.0001-0.002份β-胡萝卜素、0.00005-0.0005份叶酸、0.0005-0.005份泛酸钙、0.00025-0.005份硒酵母、0.01-0.1份葡萄糖酸锌、0.005-0.03份富马酸亚铁、0.01-0.1份氧化镁、0.5-5份L-乳酸钙、1-12份鱼胶原蛋白、0.3-3份葡萄籽提取物。
2.一种治疗女性不孕不育的药物,其特征在于:包括如下重量份的原料制备而成:15-25份山药、8-15份黄精、5-12份枸杞子、3-10份阿胶、3-10份佛手、0.8-3份红枣、3-10份槐米、8-15份桑葚、8-15份龙眼肉、0.2-0.8份覆盆子、5-12份当归、3-10份桑叶、1-3份西红花、15-25份干鱼膘、2-8份氨基酸、0.015-0.03份维生素、0.0005-0.0015份β-胡萝卜素、0.00008-0.0003份叶酸、0.001-0.003份泛酸钙、0.0001-0.003份硒酵母、0.02-0.05份葡萄糖酸锌、0.01-0.02份富马酸亚铁、0.05-0.08份氧化镁、1-3份L-乳酸钙、3-10份鱼胶原蛋白、0.5-2份葡萄籽提取物。
3.根据权利要求1所述的治疗女性不孕不育的药物,其特征在于:包括如下重量份的原料制备而成:20份山药、10份黄精、8份枸杞子、6份阿胶、6.67份佛手、1份红枣、6.67份槐米、10份桑葚、10份龙眼肉、0.4份覆盆子、8份当归、6.6份桑叶、2份西红花、20份干鱼膘、3.5份氨基酸、0.02份维生素、0.001份β-胡萝卜素、0.0001份叶酸、0.0015份泛酸钙、0.00125份硒酵母、0.026份葡萄糖酸锌、0.012份富马酸亚铁、0.066份氧化镁、1.5份L-乳酸钙、6.93669份鱼胶原蛋白、0.8份葡萄籽提取物。
4.根据权利要求1所述的治疗女性不孕不育的药物,其特征在于:所述的维生素包括维生素A、维生素B1、维生素B2、维生素B3、维生素B6、维生素B12、维生素C、维生素D、维生素E中的一种或至少两种的混合物。
5.根据权利要求1所述的治疗女性不孕不育的药物,其特征在于:所述的氨基酸包括精氨酸、DL-蛋氨酸、半胱氨酸中的一种或至少两种的混合物。
6.根据权利要求1所述的治疗女性不孕不育的药物,其特征在于:所述原料还包括5-20重量份的调味剂,所述调味剂为葡萄糖、果糖、蔗糖、麦芽糖、淀粉糖、乳糖、木糖醇和蜂蜜中的一种或至少两种的组合。
7.权利要求1-6任一所述的治疗女性不孕不育的药物的制备方法,其特征在于:包括如下步骤:
步骤1、将山药、黄精、枸杞、阿胶、佛手、槐米、桑葚、龙眼肉、当归、桑叶、西红花、干鱼膘分别进行干燥、粉碎后,进行混合,得到第一粉末混合物;
步骤2、向所述第一粉末混合物中加入乙醇,浸泡20-30min,并在60-80℃回流提取2-8小时,之后回收乙醇,得到提取液;将所述提取液进行过滤、浓缩,干燥,得到第二粉末混合物;
步骤3、将红枣、泛酸钙、硒酵母、葡萄糖酸锌、富马酸亚铁、氧化镁、L-乳酸钙、鱼胶原蛋白、葡萄籽提取物分别进行干燥、粉碎后,进行混合,得到第三粉末混合物;
步骤4、将所述第二粉末混合物与所述第三粉末混合物进行混合后,依次加入氨基酸、维生素、β-胡萝卜素、叶酸进行充分混合,得到所述治疗女性不孕不育的药物。
8.根据权利要求7所述的治疗女性不孕不育的药物的制备方法,其特征在于:所述第一粉末混合物的粒径为150-300目;所述第三粉末混合物的粒径为150-300目。
9.根据权利要求7所述的治疗女性不孕不育的药物的制备方法,其特征在于:步骤2中,所述乙醇的体积浓度为60-80%。
10.根据权利要求7所述的治疗女性不孕不育的药物的制备方法,其特征在于:步骤2中,所述第一粉末混合物的质量与所述乙醇的体积比为1:3-8g/ml。
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