CN105999154A - Scar removing liquid and preparing method thereof - Google Patents
Scar removing liquid and preparing method thereof Download PDFInfo
- Publication number
- CN105999154A CN105999154A CN201610407760.3A CN201610407760A CN105999154A CN 105999154 A CN105999154 A CN 105999154A CN 201610407760 A CN201610407760 A CN 201610407760A CN 105999154 A CN105999154 A CN 105999154A
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- CN
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- Prior art keywords
- parts
- volatile oil
- radix
- scar
- radix angelicae
- Prior art date
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Abstract
The invention belongs to the field of Chinese herbal preparations, and relates to scar removing liquid and a preparing method thereof. The scar removing liquid is prepared from, by weight, radix notoginseng, ginger slice, fructus gardenia, tortoiseshell, flos carthami, radix angelica sinensis, gallnut, centipede, squama manis, leech, camphor, borneol, Sichuan lovage rhizome, radix angelicae, peach kernel, ground beetle, lumbricus, dragon blood, suberect spatholobus stem and spreading hedyotis herb. Compared with the prior art, the scar removing liquid has the advantage that scientific matching is adopted, volatile oil is prepared from radix notoginseng, ginger slice, radix angelica sinensis and the like, water extract is prepared from fructus gardenia, tortoiseshell, flos carthami, gallnut and the like, the volatile oil and the water extract are mixed, effective constituents in all the traditional Chinese medicine materials are fully utilized, and then the functions of lightening scars and whitening skin are realized.
Description
Technical field
The invention belongs to field of traditional Chinese, relate to one and dispel scar liquid and preparation method thereof.
Background technology
Cicatrix be the detrimental effect of the factors such as physics, biology, chemistry in human body skin soft tissue, cause skin
The major injury of soft tissue and can not the most normally repair, turn by fibrous tissue replacement reparation stay i.e.
Affect outward appearance and affect again the local symptom of function.
According to the feature of cicatrix, medically, this refers at skin shallow typically cicatrix to be divided into shallow cicatrix
A kind of cicatrix on top layer, how caused by skin minor abrasions or superficial burn (high dermis), its appearance
Slightly differ from normal skin, rough surface or have pigment change, general nonfunctional obstacle, As time goes on,
Cicatrix will be the most inconspicuous by shallow cicatrix, and the most this kind of cicatrix is typically not required to process;Atrophic cicatrix is one
Plant the most stable scar tissue, also known as unstable cicatrix, be common in large-area burn, the most deeply
And the wound surface of fat deposit, only make wound healing by the growth of surrounding epithelial cell without skin-grafting.It addition,
The prolonged treatment of chronic ulcer at shank or other positions and heal, fall within the cicatrix of this character.This
The feature of cicatrix is: cicatrix epidermis is belittled, and surface is smooth, and local blood circulation is poor, in brilliant white and substrate
Harder.Owing to its top layer only covers the epithelial cell of one layer of atrophy, cannot stand external force friction, normal cracky
Atrophic cicatrix and form ulcer, general be difficult to healing, prolonged may result in is cancerated.Because this type of cicatrix often with
Muscle, nerve, blood vessel adhesion below, and have the biggest contractility, thus can tractive normal structure and cause or compare
The dysfunction that Hyp.ertrophic scar is even more serious.Owing to this cicatrix has a strongest destructiveness, therefore it should be noted that
Prevention, should early make skin graft, not be allowed to spontaneous recovery;Contracted cicatrix is with the name of its dysfunction feature caused
Cicatrix.After being more common in deep burn healing, owing to cicatrix shrinks, often result in profile and change and dysfunction,
Long-term scar contracture can affect the growth of the tissues such as skeleton, muscle, blood vessel, nerve, should process early.
The most common deformity caused because of scar contracture has ectropion, cheilectropion, mento sternal adhesion, hand cicatrix
Contracture deformity and the side in the wrong in each joint or stretch side contracture deformity etc..The streak cicatrix contraction in face is wherein bent in joint
Contracting, as through the long period, skin and the subcutaneous tissue of contracture cicatrix both sides can gradually extend, and become web shape
Scar contracture, claim web shape contracture cicatrix.This kind of web shape cicatrix the greater is common in side, throat, axillary fossa, elbow
Nest, ankle joint etc., smaller is found in endocanthion angle, angle of eye lateral, nasolabial fold, bicker, refers to the positions such as web,
Part occurs at the contracted cicatrix of opening in body surface duct in the form of a ring, and causing its bore narrow, impact is normal
Function.The contracture cicatrix of web shape all can use Z-plasty principle to carry out surgical repair;Depressed scar, when
Scar tissue when body surface causes depressed deformity, referred to as depressed scar.It is common in variola, chickenpox or acne
After the cicatrix left over, it is possible to see and outer injure skin infection patient.Simple depressed scar is only wire scar
Trace and region thereof sunken, depressed scar then can be associated with subcutaneous tissue, muscle or skeletal tissue widely
Defect.Cicatrix substrate, together with deep part muscle or adhesion of tendon, will correct this deformity not depressed scar
But the cicatrix on skin to be processed, but also different methods is used to repair according to the weight of sinking degree
Defect, to recover normal appearance;Operative scar, postoperative meeting leaves operative scar, and this is inevitable.
The selection of operative incision can affect surgical effect also can affect the shape size depth etc. of operative scar, therefore hands
Select correct operative incision during art, or lay excellent basis for elimination operative scar later.
What cicatrix brought to patient is that the huge human body is painful and psychic pain, especially burns, scalds, sternly
The cicatrix left over after weight wound.Several years of scar hyperplasia phase almost allow patient suffer untold misery.Withering then
The contracting phase makes again patient changed beyond recognition, dysfunction, causes the great body of patient, heart double combination obstacle.
At present, in prior art, mostly means for cicatrix are by skin grafting, by patient body
A certain amount of skin is chosen at other positions, transplants, although this method can make patient exposed outside
Cicatrix remove, but can other positions of health produce cicatrix, meanwhile, skin-grafting during, right
The physical and mental health of patient also has injury greatly.Also have and utilize some chemical drugss exactly, delay by smearing
Solving injured skin, with the purpose of the scar that reaches to dispel, but it is owing to for chemicals, inherently having certain
Toxicity, skin can be caused other to injure easily by long use.
Summary of the invention
The present invention is directed to the technical problem that above-mentioned treatment cicatrix exists, a kind of formula of proposition is reasonable, processing branch
Learn, therapeutic effect is good and does not contains scar liquid and preparation method thereof of dispelling of any chemical addition agent.
In order to achieve the above object, the technical solution used in the present invention is, the present invention provides one to dispel scar liquid,
Following active ingredient is included: Radix Notoginseng 5 parts~10 parts according to parts by weight;Rhizoma Zingiberis 1 part~5 parts;Fructus Gardeniae 5 parts
~10 parts;Carapax et Plastrum Testudinis 10 parts~20 parts;Flos Carthami: 25 parts~30 parts;Radix Angelicae Sinensis 20 parts~30 parts;Galla Chinensis 45
Part~60 parts;Scolopendra 2~5;Squama Manis 2 parts~5 parts;Hirudo 2 parts~5 parts;Camphora 10 parts~15
Part;Borneolum Syntheticum 1 part~5 parts;Rhizoma Chuanxiong 10 parts~20 parts;The Radix Angelicae Dahuricae 10 parts~15 parts;3 parts~8 parts of Semen Persicae;Soil
Trionyx sinensis Wiegmann worm 3 parts~8 parts;Pheretima 2 parts~7 parts;Sanguis Draxonis 10 parts~20 parts;Caulis Spatholobi 10 parts~20 parts;Spend in vain
Herba Hedyotidis Diffusae 30 parts~40 parts.
As preferably, above-mentioned scar liquid of dispelling, include following active ingredient according to parts by weight: Radix Notoginseng 7 parts;
Rhizoma Zingiberis 3 parts;Fructus Gardeniae 6 parts;Carapax et Plastrum Testudinis 12 parts;Flos Carthami: 28 parts;Radix Angelicae Sinensis 25 parts;Galla Chinensis 57 parts;
Scolopendra 3;Squama Manis 3 parts;Hirudo 2 parts;Camphora 13 parts;Borneolum Syntheticum 2 parts;Rhizoma Chuanxiong 115 parts;The Radix Angelicae Dahuricae
13 parts;5 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 4 parts;Pheretima 5 parts;Sanguis Draxonis 15 parts;Caulis Spatholobi 17 parts;Agkistrodon
SHECAO 28 parts.
Present invention also offers the preparation method of above-mentioned scar liquid of dispelling, comprise the following steps:
A, first the Radix Notoginseng of above-mentioned parts by weight, Rhizoma Zingiberis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Hedyotidis Diffusae are weighed
Grass, carries out pulverizing in powder by pulverizer, obtains by the Chinese drugs powder after 10 mesh sieves;
B, the medicine crushed is joined in heating kettle, and in heating kettle, add a certain amount of saturated chlorination
Sodium solution, then connects volatile oil determination apparatus and reflux condensing tube by heating kettle, and autocondensation pipe upper end adds water
Make water be full of the scale part of volatile oil determination apparatus, and when overflow enters heating kettle till, then from condensing tube upper end
Add normal hexane, and heat heating kettle;
C, boiling in heating kettle, will be heated to, and then, control temperature and keep little boilings 5 minutes at 90 °, then
Stop heating;
D, standing, after 10 minutes, are opened volatile oil determination apparatus lower end piston and are slowly released by water, collect volatilization
Oil, is then dehydrated volatile oil with anhydrous sodium sulfate, and finally at 50 DEG C, water-bath 3h flings to normal hexane,
To volatile oil, standby;
E, the Fructus Gardeniae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis, Scolopendra, Squama Manis, water are weighed
Trematodiasis, Camphora, Borneolum Syntheticum, Semen Persicae, Eupolyphaga Seu Steleophaga, Pheretima, Sanguis Draxonis, Caulis Spatholobi, pulverized by pulverizer
In powder, obtain by the Chinese drugs powder after 50 mesh sieves;
F, being added in molten device by the Chinese drugs powder after screening, the ethanol selecting concentration to be 65% is solvent, adds
Entering in container, Chinese medicine is carried out moistening, wetting time is 3 hours;
After g, end to be moistened, the Chinese drugs powder in container is shifted in percolator, alcohol solvent is continuous
From the top of percolator add, until alcohol solvent is by Chinese drugs powder submergence, add a cover placement 36 hours
After, collect percolate;
H, the percolate purification by gathering, concentration;
I, will purify concentrate after percolate and volatile oil mixing, i.e. obtain scar liquid of dispelling.
As preferably, in described h step, percolate uses the method for vacuum membrane distillation to purify percolate,
Concentrate.
Compared with prior art, advantages of the present invention and good effect are,
1, the present invention is by providing the cooperation of a kind of science, utilizes the Chinese herbal medicine such as Radix Notoginseng, Rhizoma Zingiberis, Radix Angelicae Sinensis to prepare
Go out its volatile oil, utilize the Chinese herbal medicine such as Fructus Gardeniae, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis to prepare its water extract, meanwhile,
By both mix, sufficiently the active ingredient of each Chinese herbal medicine is utilized, so reach desalinate cicatrix,
The effect of skin whitening.
2, the present invention is with Chinese herbal medicine as raw material, without the interpolation of any chemical agent, pure green, pollution-free, and
Long-time use, can significantly lift, firm skin, reach to nourish the effect of skin.
Detailed description of the invention
In order to be more clearly understood that the above-mentioned purpose of the present invention, feature and advantage, below in conjunction with embodiment
The present invention will be further described.It should be noted that in the case of not conflicting, embodiments herein
And the feature in embodiment can be mutually combined.
Elaborate a lot of detail in the following description so that fully understanding the present invention, but, this
Bright can be different from other modes described here implement to use, therefore, the present invention is not limited to following
The restriction of the specific embodiment of prospectus.
Embodiment 1, the present embodiment provides one to dispel scar liquid, includes following active ingredient according to parts by weight:
Radix Notoginseng 5 parts;Rhizoma Zingiberis 1 part;Fructus Gardeniae 5 parts;Carapax et Plastrum Testudinis 20 parts;Flos Carthami: 25 parts;Radix Angelicae Sinensis 20 parts;Five times
Son 45 parts;Scolopendra 2;Squama Manis 2 parts;Hirudo 2 parts;Camphora 10 parts;Borneolum Syntheticum 1 part;Rhizoma Chuanxiong 10
Part;The Radix Angelicae Dahuricae 10 parts;3 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 3 parts;Pheretima 2 parts;Sanguis Draxonis 10 parts;Caulis Spatholobi 10
Part;Herba Hedyotidis Diffusae 30 parts.
First the Radix Notoginseng of above-mentioned parts by weight, Rhizoma Zingiberis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Hedyotidis Diffusae have been weighed,
Carry out pulverizing in powder by pulverizer, obtain and (Chinese crude drug is processed by the Chinese drugs powder after 10 mesh sieves
Powdered have the volatile oil is drawn utilizing the later stage, and its degree pulverized is the least, the most easily extracts), by powder
Broken good medicine joins in heating kettle, and adds a certain amount of saturated nacl aqueous solution, chlorine in heating kettle
Change the addition of sodium solution according to being that 3:1 adds with Chinese medicine volume ratio.Add sodium chloride solution has two
Individual purpose, the water being to provide needed for steaming and decocting, another one is exactly oil-water separation, then by heating kettle
Connecting volatile oil determination apparatus and reflux condensing tube, autocondensation pipe upper end adds water and makes water be full of volatile oil determination apparatus
Scale part, and when overflow enters heating kettle till, then add normal hexane from condensing tube upper end, hexane
Addition to lack a lot, controls its volume ratio with Chinese drugs powder at about 1:10, and heating
Still, the Main Function adding hexane is constant volume, and the convenient amount to volatile oil determines accurately;To add
It is heated to boiling in hot still, then, controls temperature and keep little boiling 5 minutes at 90 °, then stop heating;
After standing 10 minutes, open volatile oil determination apparatus lower end piston and water is slowly released, collect volatile oil, then
Being dehydrated volatile oil with anhydrous sodium sulfate, finally at 50 DEG C, water-bath 3h flings to normal hexane, obtains volatile oil,
Standby;
Then, weighed the Fructus Gardeniae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis, Scolopendra, Squama Manis,
Hirudo, Camphora, Borneolum Syntheticum, Semen Persicae, Eupolyphaga Seu Steleophaga, Pheretima, Sanguis Draxonis, Caulis Spatholobi, carry out powder by pulverizer
Broken in powder, obtain by the Chinese drugs powder after 50 mesh sieves;Chinese drugs powder after screening is added molten device
In, the ethanol selecting concentration to be 65% is solvent, joins in container, Chinese medicine is carried out moistening, during moistening
Between be 3 hours;After end to be moistened, the Chinese drugs powder in container is shifted in percolator, by ethanol
Solvent continuous print adds from the top of percolator, until alcohol solvent is by Chinese drugs powder submergence, adds a cover placement
After 36 hours, collect percolate;
Then the method for the vacuum membrane distillation percolate to gathering is utilized to purify, concentrate, vacuum membrane distillation
It is through side vacuum pump evacuation, to cause the bigger steam pressure difference in film both sides, the volatilization group in percolate
Part condenses after cold side is drawn, and then reaches the purpose purifying, concentrating, and cocnentration factor is at 1.5:1.?
After will purify concentrate after percolate and volatile oil mixing, i.e. obtain scar liquid of dispelling.
In above formula, in the volatile oil of Radix Notoginseng containing ginsenoside Rg1, Quercetin, acetic acid, Flos Caryophylli alkene,
Ginsenoside Re, leucine, β-sitoesterol-D-Glucose glycosides, panaxytiol, arasaponin
Deng 12 kinds of monomer saponins and hemostatic compositions dencichine, there is dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain;Rhizoma Zingiberis
Volatile oil in containing zingiberone, 6-gingerol, β-heerabolene, α-curcumene, β
The active ingredients such as-sesquiphellandrene and zingiberol, d-camphene, eucalyptol, citral, Borneolum Syntheticum, have antiinflammatory and
Antipyretic analgesic effect;Radix Angelicae Sinensis volatile oil is mainly composed of ligustilide, butylidenephalide and angelicone
Deng, still containing vitamin B12 and the various trace elements such as ferrum, zinc.Another containing ferulic acid, 1-Phenylethanone., Rhizoma Acori Graminei two
Alkene, carvacrol, guaiacol, anisic acid, angelica lactone, Diligustilide etc., have antiinflammatory
Analgesia, antibody Monoclonal, antibacterial effect;In the volatile oil of Rhizoma Chuanxiong main constituent be ligustilide account for 58%, 3-fourth
Lactone 5.29% and sabinene 6.08%, also containing ferulic acid, river indole, 3-butylidenephthalide, myrcene,
The compositions such as ligustrazine, Palmic acid, daucosterol, β-sitoesterol, have blood-activating and qi-promoting, the merit of wind-expelling pain-stopping
Effect;Essential Oil of Radix Angelicae Dahuricae detects 29 kinds of compounds, what content was higher have methyl ring certain herbaceous plants with big flowers alkane, tetradecene,
Ethyl laurate, several furocoumarins.The most also containing imperatorin, angelicotoxin, scopoletin, white
Angelicin, different imperatorin, hydration byak-angelicin, different time sedanonic acid lactone, oxypeucedanin, anethole,
Carvacrol, Palmic acid etc., have the dehumidifying of scattered wind, sensible pain relieving, effect of detumescence and apocenosis;Herba Hedyotidis Diffusae
Volatile oil in extract to obtain 34 kinds of compounds, the most most importantly 4-Vinyl phenol, to vinyl more wound
Wood phenol and linalool, have effect of heat clearing away, dampness removing, removing toxic substances.
And, Fructus Gardeniae has effect of cooling blood for hemostasis, clearing away heat-fire, reducing swelling and alleviating pain;Carapax et Plastrum Testudinis then containing cholesterol,
Ossein, hydrolysate, containing several amino acids, fat, protein and calcium salt etc., has the effect of reinforcing the heart of nourishing blood;
Flos Carthami then promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain, more can coordinate with Semen Persicae, Radix Angelicae Sinensis so that it is better;
Galla Chinensis is then monarch drug provided by the present invention, and its astriction can make the local organization protein coagulating of skin
And play astriction, and then reach compact skin, the effect of desalination cicatrix;Scolopendra, Squama Manis, Hirudo are equal
There is the effect restored menstrual flow and invigorated blood circulation;Camphora then has warming and odynolysis, effect of stimulating central nervous system system;Borneolum Syntheticum
Effect with Camphora is similar, refreshment of having one's ideas straightened out, effect of clearing away heat to alleviate pain;Semen Persicae is then containing amygdaloside, Fructus seu semen pruni szechuanicae
Glycosides, 2,4-methine Mactra sulcatria Deshayes A Erting alcohol, sweetbrier polyantha glycosides, allantoin, vitamin B1, emulsin,
Fatty oil, fatty acid, protein etc..There is anticoagulation, improve the effects such as blood flow, antiinflammatory and antiallergic;
Eupolyphaga Seu Steleophaga contains containing protein, volatile oil, fatty acid, aminoacid, sterol and various trace elements, has
Removing blood stasis with potent drugs blood, effect of reuniting the fractured tendons and bones;Pheretima then has antipyretic effect;Sanguis Draxonis is then the ministerial drug of the present invention, with
Reach effect of removing blood stasis and relieving pain, hemostasia and promoting granulation;Caulis Spatholobi then have enrich blood, invigorate blood circulation, dredging collateral, have antiinflammatory
Effect.
By the cooperation of said herbal medicine, use the combination principle of monarch, and then reach to desalinate cicatrix,
Whitening, the purpose of the skin that compacts.
Embodiment 2, the present embodiment provides one to dispel scar liquid, includes following active ingredient according to parts by weight:
Radix Notoginseng 7 parts;Rhizoma Zingiberis 3 parts;Fructus Gardeniae 6 parts;Carapax et Plastrum Testudinis 12 parts;Flos Carthami: 28 parts;Radix Angelicae Sinensis 25 parts;Five times
Son 57 parts;Scolopendra 3;Squama Manis 3 parts;Hirudo 2 parts;Camphora 13 parts;Borneolum Syntheticum 2 parts;Rhizoma Chuanxiong 115
Part;The Radix Angelicae Dahuricae 13 parts;5 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 4 parts;Pheretima 5 parts;Sanguis Draxonis 15 parts;Caulis Spatholobi 17
Part;Herba Hedyotidis Diffusae 28 parts.
First the Radix Notoginseng of above-mentioned parts by weight, Rhizoma Zingiberis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Hedyotidis Diffusae have been weighed,
Carry out pulverizing in powder by pulverizer, obtain and (Chinese crude drug is processed by the Chinese drugs powder after 10 mesh sieves
Powdered have the volatile oil is drawn utilizing the later stage, and its degree pulverized is the least, the most easily extracts), by powder
Broken good medicine joins in heating kettle, and adds a certain amount of saturated nacl aqueous solution, chlorine in heating kettle
Change the addition of sodium solution according to being that 3:1 adds with Chinese medicine volume ratio.Add sodium chloride solution has two
Individual purpose, the water being to provide needed for steaming and decocting, another one is exactly oil-water separation, then by heating kettle
Connecting volatile oil determination apparatus and reflux condensing tube, autocondensation pipe upper end adds water and makes water be full of volatile oil determination apparatus
Scale part, and when overflow enters heating kettle till, then add normal hexane from condensing tube upper end, hexane
Addition to lack a lot, controls its volume ratio with Chinese drugs powder at about 1:10, and heating
Still, the Main Function adding hexane is constant volume, and the convenient amount to volatile oil determines accurately;To add
It is heated to boiling in hot still, then, controls temperature and keep little boiling 5 minutes at 90 °, then stop heating;
After standing 10 minutes, open volatile oil determination apparatus lower end piston and water is slowly released, collect volatile oil, then
Being dehydrated volatile oil with anhydrous sodium sulfate, finally at 50 DEG C, water-bath 3h flings to normal hexane, obtains volatile oil,
Standby;
Then, weighed the Fructus Gardeniae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis, Scolopendra, Squama Manis,
Hirudo, Camphora, Borneolum Syntheticum, Semen Persicae, Eupolyphaga Seu Steleophaga, Pheretima, Sanguis Draxonis, Caulis Spatholobi, carry out powder by pulverizer
Broken in powder, obtain by the Chinese drugs powder after 50 mesh sieves;Chinese drugs powder after screening is added molten device
In, the ethanol selecting concentration to be 65% is solvent, joins in container, Chinese medicine is carried out moistening, during moistening
Between be 3 hours;After end to be moistened, the Chinese drugs powder in container is shifted in percolator, by ethanol
Solvent continuous print adds from the top of percolator, until alcohol solvent is by Chinese drugs powder submergence, adds a cover placement
After 36 hours, collect percolate;
Then the method for the vacuum membrane distillation percolate to gathering is utilized to purify, concentrate, vacuum membrane distillation
It is through side vacuum pump evacuation, to cause the bigger steam pressure difference in film both sides, the volatilization group in percolate
Part condenses after cold side is drawn, and then reaches the purpose purifying, concentrating, and cocnentration factor is at 1.5:1.?
After will purify concentrate after percolate and volatile oil mixing, i.e. obtain scar liquid of dispelling.
Embodiment 3, the present embodiment provides one to dispel scar liquid, includes following active ingredient according to parts by weight:
Radix Notoginseng 10 parts;Rhizoma Zingiberis 5 parts;Fructus Gardeniae 10 parts;Carapax et Plastrum Testudinis 10 parts;Flos Carthami: 30 parts;Radix Angelicae Sinensis 30 parts;Five
Gall nut 60 parts;Scolopendra 5;Squama Manis 5 parts;Hirudo 5 parts;Camphora 15 parts;Borneolum Syntheticum 5 parts;Rhizoma Chuanxiong
20 parts;The Radix Angelicae Dahuricae 5 parts;8 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 8 parts;Pheretima 7 parts;Sanguis Draxonis 20 parts;Caulis Spatholobi 20
Part;Herba Hedyotidis Diffusae 40 parts.
First the Radix Notoginseng of above-mentioned parts by weight, Rhizoma Zingiberis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Hedyotidis Diffusae have been weighed,
Carry out pulverizing in powder by pulverizer, obtain and (Chinese crude drug is processed by the Chinese drugs powder after 10 mesh sieves
Powdered have the volatile oil is drawn utilizing the later stage, and its degree pulverized is the least, the most easily extracts), by powder
Broken good medicine joins in heating kettle, and adds a certain amount of saturated nacl aqueous solution, chlorine in heating kettle
Change the addition of sodium solution according to being that 3:1 adds with Chinese medicine volume ratio.Add sodium chloride solution has two
Individual purpose, the water being to provide needed for steaming and decocting, another one is exactly oil-water separation, then by heating kettle
Connecting volatile oil determination apparatus and reflux condensing tube, autocondensation pipe upper end adds water and makes water be full of volatile oil determination apparatus
Scale part, and when overflow enters heating kettle till, then add normal hexane from condensing tube upper end, hexane
Addition to lack a lot, controls its volume ratio with Chinese drugs powder at about 1:10, and heating
Still, the Main Function adding hexane is constant volume, and the convenient amount to volatile oil determines accurately;To add
It is heated to boiling in hot still, then, controls temperature and keep little boiling 5 minutes at 90 °, then stop heating;
After standing 10 minutes, open volatile oil determination apparatus lower end piston and water is slowly released, collect volatile oil, then
Being dehydrated volatile oil with anhydrous sodium sulfate, finally at 50 DEG C, water-bath 3h flings to normal hexane, obtains volatile oil,
Standby;
Then, weighed the Fructus Gardeniae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis, Scolopendra, Squama Manis,
Hirudo, Camphora, Borneolum Syntheticum, Semen Persicae, Eupolyphaga Seu Steleophaga, Pheretima, Sanguis Draxonis, Caulis Spatholobi, carry out powder by pulverizer
Broken in powder, obtain by the Chinese drugs powder after 50 mesh sieves;Chinese drugs powder after screening is added molten device
In, the ethanol selecting concentration to be 65% is solvent, joins in container, Chinese medicine is carried out moistening, during moistening
Between be 3 hours;After end to be moistened, the Chinese drugs powder in container is shifted in percolator, by ethanol
Solvent continuous print adds from the top of percolator, until alcohol solvent is by Chinese drugs powder submergence, adds a cover placement
After 36 hours, collect percolate;
Then the method for the vacuum membrane distillation percolate to gathering is utilized to purify, concentrate, vacuum membrane distillation
It is through side vacuum pump evacuation, to cause the bigger steam pressure difference in film both sides, the volatilization group in percolate
Part condenses after cold side is drawn, and then reaches the purpose purifying, concentrating, and cocnentration factor is at 1.5:1.?
After will purify concentrate after percolate and volatile oil mixing, i.e. obtain scar liquid of dispelling.
The above, be only presently preferred embodiments of the present invention, and the present invention not makees other form
Limiting, any those skilled in the art are changed possibly also with the technology contents of the disclosure above or are changed
Type is that the Equivalent embodiments of equivalent variations is applied to other field, but every without departing from technical solution of the present invention
Content, any simple modification above example made according to the technical spirit of the present invention, equivalent variations with
Remodeling, still falls within the protection domain of technical solution of the present invention.
Claims (4)
1. a scar liquid of dispelling, it is characterised in that include following active ingredient according to parts by weight: Radix Notoginseng 5
Part~10 parts;Rhizoma Zingiberis 1 part~5 parts;Fructus Gardeniae 5 parts~10 parts;Carapax et Plastrum Testudinis 10 parts~20 parts;Flos Carthami: 25 parts~30
Part;Radix Angelicae Sinensis 20 parts~30 parts;Galla Chinensis 45 parts~60 parts;Scolopendra 2~5;Squama Manis 2 parts~5 parts;
Hirudo 2 parts~5 parts;Camphora 10 parts~15 parts;Borneolum Syntheticum 1 part~5 parts;Rhizoma Chuanxiong 10 parts~20 parts;The Radix Angelicae Dahuricae 10
Part~15 parts;3 parts~8 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 3 parts~8 parts;Pheretima 2 parts~7 parts;Sanguis Draxonis 10 parts~20
Part;Caulis Spatholobi 10 parts~20 parts;Herba Hedyotidis Diffusae 30 parts~40 parts.
Scar liquid of dispelling the most according to claim 1, it is characterised in that include following having according to parts by weight
Effective constituent: Radix Notoginseng 7 parts;Rhizoma Zingiberis 3 parts;Fructus Gardeniae 6 parts;Carapax et Plastrum Testudinis 12 parts;Flos Carthami: 28 parts;Radix Angelicae Sinensis 25
Part;Galla Chinensis 57 parts;Scolopendra 3;Squama Manis 3 parts;Hirudo 2 parts;Camphora 13 parts;Borneolum Syntheticum 2 parts;
Rhizoma Chuanxiong 115 parts;The Radix Angelicae Dahuricae 13 parts;5 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 4 parts;Pheretima 5 parts;Sanguis Draxonis 15 parts;Chicken
Caulis seu Radix Schisandrae Henryi 17 parts;Herba Hedyotidis Diffusae 28 parts.
3. the method preparing scar liquid of dispelling described in above-mentioned 1~2 any one, it is characterised in that include following step
Rapid:
A, first the Radix Notoginseng of above-mentioned parts by weight, Rhizoma Zingiberis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Hedyotidis Diffusae are weighed
Grass, carries out pulverizing in powder by pulverizer, obtains by the Chinese drugs powder after 10 mesh sieves;
B, the medicine crushed is joined in heating kettle, and in heating kettle, add a certain amount of saturated chlorination
Sodium solution, then connects volatile oil determination apparatus and reflux condensing tube, autocondensation pipe upper end by heating kettle
Add water the scale part making water be full of volatile oil determination apparatus, and when overflow enters heating kettle till, then from cold
Solidifying pipe upper end adds normal hexane, and heats heating kettle;
C, boiling in heating kettle, will be heated to, and then, control temperature and keep little boilings 5 minutes at 90 °, then
Stop heating;
D, standing, after 10 minutes, are opened volatile oil determination apparatus lower end piston and are slowly released by water, collect volatilization
Oil, is then dehydrated volatile oil with anhydrous sodium sulfate, and finally at 50 DEG C, water-bath 3h flings to normal hexane,
Obtain volatile oil, standby;
E, the Fructus Gardeniae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis, Scolopendra, Squama Manis, water are weighed
Trematodiasis, Camphora, Borneolum Syntheticum, Semen Persicae, Eupolyphaga Seu Steleophaga, Pheretima, Sanguis Draxonis, Caulis Spatholobi, carried out by pulverizer
Pulverize in powder, obtain by the Chinese drugs powder after 50 mesh sieves;
F, being added in molten device by the Chinese drugs powder after screening, the ethanol selecting concentration to be 65% is solvent, adds
Entering in container, Chinese medicine is carried out moistening, wetting time is 3 hours;
After g, end to be moistened, the Chinese drugs powder in container is shifted in percolator, alcohol solvent is continuous
From the top of percolator add, until alcohol solvent is by Chinese drugs powder submergence, add a cover placement 36
After hour, collect percolate;
H, the percolate purification by gathering, concentration;
I, will purify concentrate after percolate and volatile oil mixing, i.e. obtain scar liquid of dispelling.
The preparation method of scar liquid of dispelling the most according to claim 3, it is characterised in that in described h step,
Percolate uses the method for vacuum membrane distillation to purify percolate, concentrate.
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107050274A (en) * | 2017-02-27 | 2017-08-18 | 河南恒济堂医药科技有限公司 | It is a kind of to treat scar, Chinese medicine liquid of acne print and preparation method thereof |
CN108014362A (en) * | 2018-02-07 | 2018-05-11 | 苏州元禾医疗器械有限公司 | A kind of preparation method of the wound dressing of dispeling scar |
CN108939034A (en) * | 2018-09-30 | 2018-12-07 | 赵升瑞 | Scar repairing paste |
CN112451632A (en) * | 2021-01-11 | 2021-03-09 | 郎浩峰 | Traditional Chinese medicine scar-removing and repairing ointment and preparation method thereof |
CN113198003A (en) * | 2021-06-22 | 2021-08-03 | 万永年 | External liquid for preventing atrophic scars after skin injury and preparation method thereof |
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CN101703460A (en) * | 2009-11-20 | 2010-05-12 | 天津嘉氏堂科技有限公司 | Chinese medicament scar-dispelling repair cream and method for preparing same |
CN102091258A (en) * | 2011-03-03 | 2011-06-15 | 吴强 | Chinese medicinal composition for dispelling scars and preparation method thereof |
CN102716161A (en) * | 2012-05-24 | 2012-10-10 | 唐伟东 | Chinese medicinal ointment for treating scar hyperplasia |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101703460A (en) * | 2009-11-20 | 2010-05-12 | 天津嘉氏堂科技有限公司 | Chinese medicament scar-dispelling repair cream and method for preparing same |
CN102091258A (en) * | 2011-03-03 | 2011-06-15 | 吴强 | Chinese medicinal composition for dispelling scars and preparation method thereof |
CN102716161A (en) * | 2012-05-24 | 2012-10-10 | 唐伟东 | Chinese medicinal ointment for treating scar hyperplasia |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107050274A (en) * | 2017-02-27 | 2017-08-18 | 河南恒济堂医药科技有限公司 | It is a kind of to treat scar, Chinese medicine liquid of acne print and preparation method thereof |
CN108014362A (en) * | 2018-02-07 | 2018-05-11 | 苏州元禾医疗器械有限公司 | A kind of preparation method of the wound dressing of dispeling scar |
CN108939034A (en) * | 2018-09-30 | 2018-12-07 | 赵升瑞 | Scar repairing paste |
CN112451632A (en) * | 2021-01-11 | 2021-03-09 | 郎浩峰 | Traditional Chinese medicine scar-removing and repairing ointment and preparation method thereof |
CN113198003A (en) * | 2021-06-22 | 2021-08-03 | 万永年 | External liquid for preventing atrophic scars after skin injury and preparation method thereof |
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