CN105999154A - Scar removing liquid and preparing method thereof - Google Patents

Scar removing liquid and preparing method thereof Download PDF

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Publication number
CN105999154A
CN105999154A CN201610407760.3A CN201610407760A CN105999154A CN 105999154 A CN105999154 A CN 105999154A CN 201610407760 A CN201610407760 A CN 201610407760A CN 105999154 A CN105999154 A CN 105999154A
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parts
volatile oil
radix
scar
radix angelicae
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宋伟亮
杜磊
沈婵华
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/12Ketones
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    • A61K31/125Camphor; Nuclear substituted derivatives thereof
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
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    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K36/74Rubiaceae (Madder family)
    • A61K36/744Gardenia
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    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/88Liliopsida (monocotyledons)
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    • A61K36/906Zingiberaceae (Ginger family)
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    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention belongs to the field of Chinese herbal preparations, and relates to scar removing liquid and a preparing method thereof. The scar removing liquid is prepared from, by weight, radix notoginseng, ginger slice, fructus gardenia, tortoiseshell, flos carthami, radix angelica sinensis, gallnut, centipede, squama manis, leech, camphor, borneol, Sichuan lovage rhizome, radix angelicae, peach kernel, ground beetle, lumbricus, dragon blood, suberect spatholobus stem and spreading hedyotis herb. Compared with the prior art, the scar removing liquid has the advantage that scientific matching is adopted, volatile oil is prepared from radix notoginseng, ginger slice, radix angelica sinensis and the like, water extract is prepared from fructus gardenia, tortoiseshell, flos carthami, gallnut and the like, the volatile oil and the water extract are mixed, effective constituents in all the traditional Chinese medicine materials are fully utilized, and then the functions of lightening scars and whitening skin are realized.

Description

Scar of dispelling liquid and preparation method thereof
Technical field
The invention belongs to field of traditional Chinese, relate to one and dispel scar liquid and preparation method thereof.
Background technology
Cicatrix be the detrimental effect of the factors such as physics, biology, chemistry in human body skin soft tissue, cause skin The major injury of soft tissue and can not the most normally repair, turn by fibrous tissue replacement reparation stay i.e. Affect outward appearance and affect again the local symptom of function.
According to the feature of cicatrix, medically, this refers at skin shallow typically cicatrix to be divided into shallow cicatrix A kind of cicatrix on top layer, how caused by skin minor abrasions or superficial burn (high dermis), its appearance Slightly differ from normal skin, rough surface or have pigment change, general nonfunctional obstacle, As time goes on, Cicatrix will be the most inconspicuous by shallow cicatrix, and the most this kind of cicatrix is typically not required to process;Atrophic cicatrix is one Plant the most stable scar tissue, also known as unstable cicatrix, be common in large-area burn, the most deeply And the wound surface of fat deposit, only make wound healing by the growth of surrounding epithelial cell without skin-grafting.It addition, The prolonged treatment of chronic ulcer at shank or other positions and heal, fall within the cicatrix of this character.This The feature of cicatrix is: cicatrix epidermis is belittled, and surface is smooth, and local blood circulation is poor, in brilliant white and substrate Harder.Owing to its top layer only covers the epithelial cell of one layer of atrophy, cannot stand external force friction, normal cracky Atrophic cicatrix and form ulcer, general be difficult to healing, prolonged may result in is cancerated.Because this type of cicatrix often with Muscle, nerve, blood vessel adhesion below, and have the biggest contractility, thus can tractive normal structure and cause or compare The dysfunction that Hyp.ertrophic scar is even more serious.Owing to this cicatrix has a strongest destructiveness, therefore it should be noted that Prevention, should early make skin graft, not be allowed to spontaneous recovery;Contracted cicatrix is with the name of its dysfunction feature caused Cicatrix.After being more common in deep burn healing, owing to cicatrix shrinks, often result in profile and change and dysfunction, Long-term scar contracture can affect the growth of the tissues such as skeleton, muscle, blood vessel, nerve, should process early. The most common deformity caused because of scar contracture has ectropion, cheilectropion, mento sternal adhesion, hand cicatrix Contracture deformity and the side in the wrong in each joint or stretch side contracture deformity etc..The streak cicatrix contraction in face is wherein bent in joint Contracting, as through the long period, skin and the subcutaneous tissue of contracture cicatrix both sides can gradually extend, and become web shape Scar contracture, claim web shape contracture cicatrix.This kind of web shape cicatrix the greater is common in side, throat, axillary fossa, elbow Nest, ankle joint etc., smaller is found in endocanthion angle, angle of eye lateral, nasolabial fold, bicker, refers to the positions such as web, Part occurs at the contracted cicatrix of opening in body surface duct in the form of a ring, and causing its bore narrow, impact is normal Function.The contracture cicatrix of web shape all can use Z-plasty principle to carry out surgical repair;Depressed scar, when Scar tissue when body surface causes depressed deformity, referred to as depressed scar.It is common in variola, chickenpox or acne After the cicatrix left over, it is possible to see and outer injure skin infection patient.Simple depressed scar is only wire scar Trace and region thereof sunken, depressed scar then can be associated with subcutaneous tissue, muscle or skeletal tissue widely Defect.Cicatrix substrate, together with deep part muscle or adhesion of tendon, will correct this deformity not depressed scar But the cicatrix on skin to be processed, but also different methods is used to repair according to the weight of sinking degree Defect, to recover normal appearance;Operative scar, postoperative meeting leaves operative scar, and this is inevitable. The selection of operative incision can affect surgical effect also can affect the shape size depth etc. of operative scar, therefore hands Select correct operative incision during art, or lay excellent basis for elimination operative scar later.
What cicatrix brought to patient is that the huge human body is painful and psychic pain, especially burns, scalds, sternly The cicatrix left over after weight wound.Several years of scar hyperplasia phase almost allow patient suffer untold misery.Withering then The contracting phase makes again patient changed beyond recognition, dysfunction, causes the great body of patient, heart double combination obstacle.
At present, in prior art, mostly means for cicatrix are by skin grafting, by patient body A certain amount of skin is chosen at other positions, transplants, although this method can make patient exposed outside Cicatrix remove, but can other positions of health produce cicatrix, meanwhile, skin-grafting during, right The physical and mental health of patient also has injury greatly.Also have and utilize some chemical drugss exactly, delay by smearing Solving injured skin, with the purpose of the scar that reaches to dispel, but it is owing to for chemicals, inherently having certain Toxicity, skin can be caused other to injure easily by long use.
Summary of the invention
The present invention is directed to the technical problem that above-mentioned treatment cicatrix exists, a kind of formula of proposition is reasonable, processing branch Learn, therapeutic effect is good and does not contains scar liquid and preparation method thereof of dispelling of any chemical addition agent.
In order to achieve the above object, the technical solution used in the present invention is, the present invention provides one to dispel scar liquid, Following active ingredient is included: Radix Notoginseng 5 parts~10 parts according to parts by weight;Rhizoma Zingiberis 1 part~5 parts;Fructus Gardeniae 5 parts ~10 parts;Carapax et Plastrum Testudinis 10 parts~20 parts;Flos Carthami: 25 parts~30 parts;Radix Angelicae Sinensis 20 parts~30 parts;Galla Chinensis 45 Part~60 parts;Scolopendra 2~5;Squama Manis 2 parts~5 parts;Hirudo 2 parts~5 parts;Camphora 10 parts~15 Part;Borneolum Syntheticum 1 part~5 parts;Rhizoma Chuanxiong 10 parts~20 parts;The Radix Angelicae Dahuricae 10 parts~15 parts;3 parts~8 parts of Semen Persicae;Soil Trionyx sinensis Wiegmann worm 3 parts~8 parts;Pheretima 2 parts~7 parts;Sanguis Draxonis 10 parts~20 parts;Caulis Spatholobi 10 parts~20 parts;Spend in vain Herba Hedyotidis Diffusae 30 parts~40 parts.
As preferably, above-mentioned scar liquid of dispelling, include following active ingredient according to parts by weight: Radix Notoginseng 7 parts; Rhizoma Zingiberis 3 parts;Fructus Gardeniae 6 parts;Carapax et Plastrum Testudinis 12 parts;Flos Carthami: 28 parts;Radix Angelicae Sinensis 25 parts;Galla Chinensis 57 parts; Scolopendra 3;Squama Manis 3 parts;Hirudo 2 parts;Camphora 13 parts;Borneolum Syntheticum 2 parts;Rhizoma Chuanxiong 115 parts;The Radix Angelicae Dahuricae 13 parts;5 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 4 parts;Pheretima 5 parts;Sanguis Draxonis 15 parts;Caulis Spatholobi 17 parts;Agkistrodon SHECAO 28 parts.
Present invention also offers the preparation method of above-mentioned scar liquid of dispelling, comprise the following steps:
A, first the Radix Notoginseng of above-mentioned parts by weight, Rhizoma Zingiberis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Hedyotidis Diffusae are weighed Grass, carries out pulverizing in powder by pulverizer, obtains by the Chinese drugs powder after 10 mesh sieves;
B, the medicine crushed is joined in heating kettle, and in heating kettle, add a certain amount of saturated chlorination Sodium solution, then connects volatile oil determination apparatus and reflux condensing tube by heating kettle, and autocondensation pipe upper end adds water Make water be full of the scale part of volatile oil determination apparatus, and when overflow enters heating kettle till, then from condensing tube upper end Add normal hexane, and heat heating kettle;
C, boiling in heating kettle, will be heated to, and then, control temperature and keep little boilings 5 minutes at 90 °, then Stop heating;
D, standing, after 10 minutes, are opened volatile oil determination apparatus lower end piston and are slowly released by water, collect volatilization Oil, is then dehydrated volatile oil with anhydrous sodium sulfate, and finally at 50 DEG C, water-bath 3h flings to normal hexane, To volatile oil, standby;
E, the Fructus Gardeniae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis, Scolopendra, Squama Manis, water are weighed Trematodiasis, Camphora, Borneolum Syntheticum, Semen Persicae, Eupolyphaga Seu Steleophaga, Pheretima, Sanguis Draxonis, Caulis Spatholobi, pulverized by pulverizer In powder, obtain by the Chinese drugs powder after 50 mesh sieves;
F, being added in molten device by the Chinese drugs powder after screening, the ethanol selecting concentration to be 65% is solvent, adds Entering in container, Chinese medicine is carried out moistening, wetting time is 3 hours;
After g, end to be moistened, the Chinese drugs powder in container is shifted in percolator, alcohol solvent is continuous From the top of percolator add, until alcohol solvent is by Chinese drugs powder submergence, add a cover placement 36 hours After, collect percolate;
H, the percolate purification by gathering, concentration;
I, will purify concentrate after percolate and volatile oil mixing, i.e. obtain scar liquid of dispelling.
As preferably, in described h step, percolate uses the method for vacuum membrane distillation to purify percolate, Concentrate.
Compared with prior art, advantages of the present invention and good effect are,
1, the present invention is by providing the cooperation of a kind of science, utilizes the Chinese herbal medicine such as Radix Notoginseng, Rhizoma Zingiberis, Radix Angelicae Sinensis to prepare Go out its volatile oil, utilize the Chinese herbal medicine such as Fructus Gardeniae, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis to prepare its water extract, meanwhile, By both mix, sufficiently the active ingredient of each Chinese herbal medicine is utilized, so reach desalinate cicatrix, The effect of skin whitening.
2, the present invention is with Chinese herbal medicine as raw material, without the interpolation of any chemical agent, pure green, pollution-free, and Long-time use, can significantly lift, firm skin, reach to nourish the effect of skin.
Detailed description of the invention
In order to be more clearly understood that the above-mentioned purpose of the present invention, feature and advantage, below in conjunction with embodiment The present invention will be further described.It should be noted that in the case of not conflicting, embodiments herein And the feature in embodiment can be mutually combined.
Elaborate a lot of detail in the following description so that fully understanding the present invention, but, this Bright can be different from other modes described here implement to use, therefore, the present invention is not limited to following The restriction of the specific embodiment of prospectus.
Embodiment 1, the present embodiment provides one to dispel scar liquid, includes following active ingredient according to parts by weight: Radix Notoginseng 5 parts;Rhizoma Zingiberis 1 part;Fructus Gardeniae 5 parts;Carapax et Plastrum Testudinis 20 parts;Flos Carthami: 25 parts;Radix Angelicae Sinensis 20 parts;Five times Son 45 parts;Scolopendra 2;Squama Manis 2 parts;Hirudo 2 parts;Camphora 10 parts;Borneolum Syntheticum 1 part;Rhizoma Chuanxiong 10 Part;The Radix Angelicae Dahuricae 10 parts;3 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 3 parts;Pheretima 2 parts;Sanguis Draxonis 10 parts;Caulis Spatholobi 10 Part;Herba Hedyotidis Diffusae 30 parts.
First the Radix Notoginseng of above-mentioned parts by weight, Rhizoma Zingiberis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Hedyotidis Diffusae have been weighed, Carry out pulverizing in powder by pulverizer, obtain and (Chinese crude drug is processed by the Chinese drugs powder after 10 mesh sieves Powdered have the volatile oil is drawn utilizing the later stage, and its degree pulverized is the least, the most easily extracts), by powder Broken good medicine joins in heating kettle, and adds a certain amount of saturated nacl aqueous solution, chlorine in heating kettle Change the addition of sodium solution according to being that 3:1 adds with Chinese medicine volume ratio.Add sodium chloride solution has two Individual purpose, the water being to provide needed for steaming and decocting, another one is exactly oil-water separation, then by heating kettle Connecting volatile oil determination apparatus and reflux condensing tube, autocondensation pipe upper end adds water and makes water be full of volatile oil determination apparatus Scale part, and when overflow enters heating kettle till, then add normal hexane from condensing tube upper end, hexane Addition to lack a lot, controls its volume ratio with Chinese drugs powder at about 1:10, and heating Still, the Main Function adding hexane is constant volume, and the convenient amount to volatile oil determines accurately;To add It is heated to boiling in hot still, then, controls temperature and keep little boiling 5 minutes at 90 °, then stop heating; After standing 10 minutes, open volatile oil determination apparatus lower end piston and water is slowly released, collect volatile oil, then Being dehydrated volatile oil with anhydrous sodium sulfate, finally at 50 DEG C, water-bath 3h flings to normal hexane, obtains volatile oil, Standby;
Then, weighed the Fructus Gardeniae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis, Scolopendra, Squama Manis, Hirudo, Camphora, Borneolum Syntheticum, Semen Persicae, Eupolyphaga Seu Steleophaga, Pheretima, Sanguis Draxonis, Caulis Spatholobi, carry out powder by pulverizer Broken in powder, obtain by the Chinese drugs powder after 50 mesh sieves;Chinese drugs powder after screening is added molten device In, the ethanol selecting concentration to be 65% is solvent, joins in container, Chinese medicine is carried out moistening, during moistening Between be 3 hours;After end to be moistened, the Chinese drugs powder in container is shifted in percolator, by ethanol Solvent continuous print adds from the top of percolator, until alcohol solvent is by Chinese drugs powder submergence, adds a cover placement After 36 hours, collect percolate;
Then the method for the vacuum membrane distillation percolate to gathering is utilized to purify, concentrate, vacuum membrane distillation It is through side vacuum pump evacuation, to cause the bigger steam pressure difference in film both sides, the volatilization group in percolate Part condenses after cold side is drawn, and then reaches the purpose purifying, concentrating, and cocnentration factor is at 1.5:1.? After will purify concentrate after percolate and volatile oil mixing, i.e. obtain scar liquid of dispelling.
In above formula, in the volatile oil of Radix Notoginseng containing ginsenoside Rg1, Quercetin, acetic acid, Flos Caryophylli alkene, Ginsenoside Re, leucine, β-sitoesterol-D-Glucose glycosides, panaxytiol, arasaponin Deng 12 kinds of monomer saponins and hemostatic compositions dencichine, there is dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain;Rhizoma Zingiberis Volatile oil in containing zingiberone, 6-gingerol, β-heerabolene, α-curcumene, β The active ingredients such as-sesquiphellandrene and zingiberol, d-camphene, eucalyptol, citral, Borneolum Syntheticum, have antiinflammatory and Antipyretic analgesic effect;Radix Angelicae Sinensis volatile oil is mainly composed of ligustilide, butylidenephalide and angelicone Deng, still containing vitamin B12 and the various trace elements such as ferrum, zinc.Another containing ferulic acid, 1-Phenylethanone., Rhizoma Acori Graminei two Alkene, carvacrol, guaiacol, anisic acid, angelica lactone, Diligustilide etc., have antiinflammatory Analgesia, antibody Monoclonal, antibacterial effect;In the volatile oil of Rhizoma Chuanxiong main constituent be ligustilide account for 58%, 3-fourth Lactone 5.29% and sabinene 6.08%, also containing ferulic acid, river indole, 3-butylidenephthalide, myrcene, The compositions such as ligustrazine, Palmic acid, daucosterol, β-sitoesterol, have blood-activating and qi-promoting, the merit of wind-expelling pain-stopping Effect;Essential Oil of Radix Angelicae Dahuricae detects 29 kinds of compounds, what content was higher have methyl ring certain herbaceous plants with big flowers alkane, tetradecene, Ethyl laurate, several furocoumarins.The most also containing imperatorin, angelicotoxin, scopoletin, white Angelicin, different imperatorin, hydration byak-angelicin, different time sedanonic acid lactone, oxypeucedanin, anethole, Carvacrol, Palmic acid etc., have the dehumidifying of scattered wind, sensible pain relieving, effect of detumescence and apocenosis;Herba Hedyotidis Diffusae Volatile oil in extract to obtain 34 kinds of compounds, the most most importantly 4-Vinyl phenol, to vinyl more wound Wood phenol and linalool, have effect of heat clearing away, dampness removing, removing toxic substances.
And, Fructus Gardeniae has effect of cooling blood for hemostasis, clearing away heat-fire, reducing swelling and alleviating pain;Carapax et Plastrum Testudinis then containing cholesterol, Ossein, hydrolysate, containing several amino acids, fat, protein and calcium salt etc., has the effect of reinforcing the heart of nourishing blood; Flos Carthami then promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain, more can coordinate with Semen Persicae, Radix Angelicae Sinensis so that it is better; Galla Chinensis is then monarch drug provided by the present invention, and its astriction can make the local organization protein coagulating of skin And play astriction, and then reach compact skin, the effect of desalination cicatrix;Scolopendra, Squama Manis, Hirudo are equal There is the effect restored menstrual flow and invigorated blood circulation;Camphora then has warming and odynolysis, effect of stimulating central nervous system system;Borneolum Syntheticum Effect with Camphora is similar, refreshment of having one's ideas straightened out, effect of clearing away heat to alleviate pain;Semen Persicae is then containing amygdaloside, Fructus seu semen pruni szechuanicae Glycosides, 2,4-methine Mactra sulcatria Deshayes A Erting alcohol, sweetbrier polyantha glycosides, allantoin, vitamin B1, emulsin, Fatty oil, fatty acid, protein etc..There is anticoagulation, improve the effects such as blood flow, antiinflammatory and antiallergic; Eupolyphaga Seu Steleophaga contains containing protein, volatile oil, fatty acid, aminoacid, sterol and various trace elements, has Removing blood stasis with potent drugs blood, effect of reuniting the fractured tendons and bones;Pheretima then has antipyretic effect;Sanguis Draxonis is then the ministerial drug of the present invention, with Reach effect of removing blood stasis and relieving pain, hemostasia and promoting granulation;Caulis Spatholobi then have enrich blood, invigorate blood circulation, dredging collateral, have antiinflammatory Effect.
By the cooperation of said herbal medicine, use the combination principle of monarch, and then reach to desalinate cicatrix, Whitening, the purpose of the skin that compacts.
Embodiment 2, the present embodiment provides one to dispel scar liquid, includes following active ingredient according to parts by weight: Radix Notoginseng 7 parts;Rhizoma Zingiberis 3 parts;Fructus Gardeniae 6 parts;Carapax et Plastrum Testudinis 12 parts;Flos Carthami: 28 parts;Radix Angelicae Sinensis 25 parts;Five times Son 57 parts;Scolopendra 3;Squama Manis 3 parts;Hirudo 2 parts;Camphora 13 parts;Borneolum Syntheticum 2 parts;Rhizoma Chuanxiong 115 Part;The Radix Angelicae Dahuricae 13 parts;5 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 4 parts;Pheretima 5 parts;Sanguis Draxonis 15 parts;Caulis Spatholobi 17 Part;Herba Hedyotidis Diffusae 28 parts.
First the Radix Notoginseng of above-mentioned parts by weight, Rhizoma Zingiberis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Hedyotidis Diffusae have been weighed, Carry out pulverizing in powder by pulverizer, obtain and (Chinese crude drug is processed by the Chinese drugs powder after 10 mesh sieves Powdered have the volatile oil is drawn utilizing the later stage, and its degree pulverized is the least, the most easily extracts), by powder Broken good medicine joins in heating kettle, and adds a certain amount of saturated nacl aqueous solution, chlorine in heating kettle Change the addition of sodium solution according to being that 3:1 adds with Chinese medicine volume ratio.Add sodium chloride solution has two Individual purpose, the water being to provide needed for steaming and decocting, another one is exactly oil-water separation, then by heating kettle Connecting volatile oil determination apparatus and reflux condensing tube, autocondensation pipe upper end adds water and makes water be full of volatile oil determination apparatus Scale part, and when overflow enters heating kettle till, then add normal hexane from condensing tube upper end, hexane Addition to lack a lot, controls its volume ratio with Chinese drugs powder at about 1:10, and heating Still, the Main Function adding hexane is constant volume, and the convenient amount to volatile oil determines accurately;To add It is heated to boiling in hot still, then, controls temperature and keep little boiling 5 minutes at 90 °, then stop heating; After standing 10 minutes, open volatile oil determination apparatus lower end piston and water is slowly released, collect volatile oil, then Being dehydrated volatile oil with anhydrous sodium sulfate, finally at 50 DEG C, water-bath 3h flings to normal hexane, obtains volatile oil, Standby;
Then, weighed the Fructus Gardeniae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis, Scolopendra, Squama Manis, Hirudo, Camphora, Borneolum Syntheticum, Semen Persicae, Eupolyphaga Seu Steleophaga, Pheretima, Sanguis Draxonis, Caulis Spatholobi, carry out powder by pulverizer Broken in powder, obtain by the Chinese drugs powder after 50 mesh sieves;Chinese drugs powder after screening is added molten device In, the ethanol selecting concentration to be 65% is solvent, joins in container, Chinese medicine is carried out moistening, during moistening Between be 3 hours;After end to be moistened, the Chinese drugs powder in container is shifted in percolator, by ethanol Solvent continuous print adds from the top of percolator, until alcohol solvent is by Chinese drugs powder submergence, adds a cover placement After 36 hours, collect percolate;
Then the method for the vacuum membrane distillation percolate to gathering is utilized to purify, concentrate, vacuum membrane distillation It is through side vacuum pump evacuation, to cause the bigger steam pressure difference in film both sides, the volatilization group in percolate Part condenses after cold side is drawn, and then reaches the purpose purifying, concentrating, and cocnentration factor is at 1.5:1.? After will purify concentrate after percolate and volatile oil mixing, i.e. obtain scar liquid of dispelling.
Embodiment 3, the present embodiment provides one to dispel scar liquid, includes following active ingredient according to parts by weight: Radix Notoginseng 10 parts;Rhizoma Zingiberis 5 parts;Fructus Gardeniae 10 parts;Carapax et Plastrum Testudinis 10 parts;Flos Carthami: 30 parts;Radix Angelicae Sinensis 30 parts;Five Gall nut 60 parts;Scolopendra 5;Squama Manis 5 parts;Hirudo 5 parts;Camphora 15 parts;Borneolum Syntheticum 5 parts;Rhizoma Chuanxiong 20 parts;The Radix Angelicae Dahuricae 5 parts;8 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 8 parts;Pheretima 7 parts;Sanguis Draxonis 20 parts;Caulis Spatholobi 20 Part;Herba Hedyotidis Diffusae 40 parts.
First the Radix Notoginseng of above-mentioned parts by weight, Rhizoma Zingiberis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Hedyotidis Diffusae have been weighed, Carry out pulverizing in powder by pulverizer, obtain and (Chinese crude drug is processed by the Chinese drugs powder after 10 mesh sieves Powdered have the volatile oil is drawn utilizing the later stage, and its degree pulverized is the least, the most easily extracts), by powder Broken good medicine joins in heating kettle, and adds a certain amount of saturated nacl aqueous solution, chlorine in heating kettle Change the addition of sodium solution according to being that 3:1 adds with Chinese medicine volume ratio.Add sodium chloride solution has two Individual purpose, the water being to provide needed for steaming and decocting, another one is exactly oil-water separation, then by heating kettle Connecting volatile oil determination apparatus and reflux condensing tube, autocondensation pipe upper end adds water and makes water be full of volatile oil determination apparatus Scale part, and when overflow enters heating kettle till, then add normal hexane from condensing tube upper end, hexane Addition to lack a lot, controls its volume ratio with Chinese drugs powder at about 1:10, and heating Still, the Main Function adding hexane is constant volume, and the convenient amount to volatile oil determines accurately;To add It is heated to boiling in hot still, then, controls temperature and keep little boiling 5 minutes at 90 °, then stop heating; After standing 10 minutes, open volatile oil determination apparatus lower end piston and water is slowly released, collect volatile oil, then Being dehydrated volatile oil with anhydrous sodium sulfate, finally at 50 DEG C, water-bath 3h flings to normal hexane, obtains volatile oil, Standby;
Then, weighed the Fructus Gardeniae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis, Scolopendra, Squama Manis, Hirudo, Camphora, Borneolum Syntheticum, Semen Persicae, Eupolyphaga Seu Steleophaga, Pheretima, Sanguis Draxonis, Caulis Spatholobi, carry out powder by pulverizer Broken in powder, obtain by the Chinese drugs powder after 50 mesh sieves;Chinese drugs powder after screening is added molten device In, the ethanol selecting concentration to be 65% is solvent, joins in container, Chinese medicine is carried out moistening, during moistening Between be 3 hours;After end to be moistened, the Chinese drugs powder in container is shifted in percolator, by ethanol Solvent continuous print adds from the top of percolator, until alcohol solvent is by Chinese drugs powder submergence, adds a cover placement After 36 hours, collect percolate;
Then the method for the vacuum membrane distillation percolate to gathering is utilized to purify, concentrate, vacuum membrane distillation It is through side vacuum pump evacuation, to cause the bigger steam pressure difference in film both sides, the volatilization group in percolate Part condenses after cold side is drawn, and then reaches the purpose purifying, concentrating, and cocnentration factor is at 1.5:1.? After will purify concentrate after percolate and volatile oil mixing, i.e. obtain scar liquid of dispelling.
The above, be only presently preferred embodiments of the present invention, and the present invention not makees other form Limiting, any those skilled in the art are changed possibly also with the technology contents of the disclosure above or are changed Type is that the Equivalent embodiments of equivalent variations is applied to other field, but every without departing from technical solution of the present invention Content, any simple modification above example made according to the technical spirit of the present invention, equivalent variations with Remodeling, still falls within the protection domain of technical solution of the present invention.

Claims (4)

1. a scar liquid of dispelling, it is characterised in that include following active ingredient according to parts by weight: Radix Notoginseng 5 Part~10 parts;Rhizoma Zingiberis 1 part~5 parts;Fructus Gardeniae 5 parts~10 parts;Carapax et Plastrum Testudinis 10 parts~20 parts;Flos Carthami: 25 parts~30 Part;Radix Angelicae Sinensis 20 parts~30 parts;Galla Chinensis 45 parts~60 parts;Scolopendra 2~5;Squama Manis 2 parts~5 parts; Hirudo 2 parts~5 parts;Camphora 10 parts~15 parts;Borneolum Syntheticum 1 part~5 parts;Rhizoma Chuanxiong 10 parts~20 parts;The Radix Angelicae Dahuricae 10 Part~15 parts;3 parts~8 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 3 parts~8 parts;Pheretima 2 parts~7 parts;Sanguis Draxonis 10 parts~20 Part;Caulis Spatholobi 10 parts~20 parts;Herba Hedyotidis Diffusae 30 parts~40 parts.
Scar liquid of dispelling the most according to claim 1, it is characterised in that include following having according to parts by weight Effective constituent: Radix Notoginseng 7 parts;Rhizoma Zingiberis 3 parts;Fructus Gardeniae 6 parts;Carapax et Plastrum Testudinis 12 parts;Flos Carthami: 28 parts;Radix Angelicae Sinensis 25 Part;Galla Chinensis 57 parts;Scolopendra 3;Squama Manis 3 parts;Hirudo 2 parts;Camphora 13 parts;Borneolum Syntheticum 2 parts; Rhizoma Chuanxiong 115 parts;The Radix Angelicae Dahuricae 13 parts;5 parts of Semen Persicae;Eupolyphaga Seu Steleophaga 4 parts;Pheretima 5 parts;Sanguis Draxonis 15 parts;Chicken Caulis seu Radix Schisandrae Henryi 17 parts;Herba Hedyotidis Diffusae 28 parts.
3. the method preparing scar liquid of dispelling described in above-mentioned 1~2 any one, it is characterised in that include following step Rapid:
A, first the Radix Notoginseng of above-mentioned parts by weight, Rhizoma Zingiberis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Hedyotidis Diffusae are weighed Grass, carries out pulverizing in powder by pulverizer, obtains by the Chinese drugs powder after 10 mesh sieves;
B, the medicine crushed is joined in heating kettle, and in heating kettle, add a certain amount of saturated chlorination Sodium solution, then connects volatile oil determination apparatus and reflux condensing tube, autocondensation pipe upper end by heating kettle Add water the scale part making water be full of volatile oil determination apparatus, and when overflow enters heating kettle till, then from cold Solidifying pipe upper end adds normal hexane, and heats heating kettle;
C, boiling in heating kettle, will be heated to, and then, control temperature and keep little boilings 5 minutes at 90 °, then Stop heating;
D, standing, after 10 minutes, are opened volatile oil determination apparatus lower end piston and are slowly released by water, collect volatilization Oil, is then dehydrated volatile oil with anhydrous sodium sulfate, and finally at 50 DEG C, water-bath 3h flings to normal hexane, Obtain volatile oil, standby;
E, the Fructus Gardeniae of above-mentioned parts by weight, Carapax et Plastrum Testudinis, Flos Carthami, Galla Chinensis, Scolopendra, Squama Manis, water are weighed Trematodiasis, Camphora, Borneolum Syntheticum, Semen Persicae, Eupolyphaga Seu Steleophaga, Pheretima, Sanguis Draxonis, Caulis Spatholobi, carried out by pulverizer Pulverize in powder, obtain by the Chinese drugs powder after 50 mesh sieves;
F, being added in molten device by the Chinese drugs powder after screening, the ethanol selecting concentration to be 65% is solvent, adds Entering in container, Chinese medicine is carried out moistening, wetting time is 3 hours;
After g, end to be moistened, the Chinese drugs powder in container is shifted in percolator, alcohol solvent is continuous From the top of percolator add, until alcohol solvent is by Chinese drugs powder submergence, add a cover placement 36 After hour, collect percolate;
H, the percolate purification by gathering, concentration;
I, will purify concentrate after percolate and volatile oil mixing, i.e. obtain scar liquid of dispelling.
The preparation method of scar liquid of dispelling the most according to claim 3, it is characterised in that in described h step, Percolate uses the method for vacuum membrane distillation to purify percolate, concentrate.
CN201610407760.3A 2016-06-07 2016-06-07 Scar removing liquid and preparing method thereof Pending CN105999154A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107050274A (en) * 2017-02-27 2017-08-18 河南恒济堂医药科技有限公司 It is a kind of to treat scar, Chinese medicine liquid of acne print and preparation method thereof
CN108014362A (en) * 2018-02-07 2018-05-11 苏州元禾医疗器械有限公司 A kind of preparation method of the wound dressing of dispeling scar
CN108939034A (en) * 2018-09-30 2018-12-07 赵升瑞 Scar repairing paste
CN112451632A (en) * 2021-01-11 2021-03-09 郎浩峰 Traditional Chinese medicine scar-removing and repairing ointment and preparation method thereof
CN113198003A (en) * 2021-06-22 2021-08-03 万永年 External liquid for preventing atrophic scars after skin injury and preparation method thereof

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CN101703460A (en) * 2009-11-20 2010-05-12 天津嘉氏堂科技有限公司 Chinese medicament scar-dispelling repair cream and method for preparing same
CN102091258A (en) * 2011-03-03 2011-06-15 吴强 Chinese medicinal composition for dispelling scars and preparation method thereof
CN102716161A (en) * 2012-05-24 2012-10-10 唐伟东 Chinese medicinal ointment for treating scar hyperplasia

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN101703460A (en) * 2009-11-20 2010-05-12 天津嘉氏堂科技有限公司 Chinese medicament scar-dispelling repair cream and method for preparing same
CN102091258A (en) * 2011-03-03 2011-06-15 吴强 Chinese medicinal composition for dispelling scars and preparation method thereof
CN102716161A (en) * 2012-05-24 2012-10-10 唐伟东 Chinese medicinal ointment for treating scar hyperplasia

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107050274A (en) * 2017-02-27 2017-08-18 河南恒济堂医药科技有限公司 It is a kind of to treat scar, Chinese medicine liquid of acne print and preparation method thereof
CN108014362A (en) * 2018-02-07 2018-05-11 苏州元禾医疗器械有限公司 A kind of preparation method of the wound dressing of dispeling scar
CN108939034A (en) * 2018-09-30 2018-12-07 赵升瑞 Scar repairing paste
CN112451632A (en) * 2021-01-11 2021-03-09 郎浩峰 Traditional Chinese medicine scar-removing and repairing ointment and preparation method thereof
CN113198003A (en) * 2021-06-22 2021-08-03 万永年 External liquid for preventing atrophic scars after skin injury and preparation method thereof

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Application publication date: 20161012