CN105998549A - Traditional Chinese medicine compound for treating chronic periodontitis - Google Patents

Traditional Chinese medicine compound for treating chronic periodontitis Download PDF

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CN105998549A
CN105998549A CN201610486586.6A CN201610486586A CN105998549A CN 105998549 A CN105998549 A CN 105998549A CN 201610486586 A CN201610486586 A CN 201610486586A CN 105998549 A CN105998549 A CN 105998549A
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chinese medicine
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何勤
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Abstract

The invention discloses a traditional Chinese medicine compound for treating chronic periodontitis. The traditional Chinese medicine compound is prepared from fruits of black jetbead, euphorbia thymifolia, herbs of bigflower clinopodium, cotoneaster multiflorus bge. leaves, pteroxygonum giraldii damme et diels, emilia fosbergii, loveyly hemsleya roots, pink reineckea herbs, lombardy poplar bark, drymaria cordata, ancients euphorbia stems, abroma angusta, zinnia elegans Jacq., fructo-oligose, propolis, prepared salt, halite, halloysitum rubrum, cellulose, pectinase, coenzyme Q10 powder and vitamin C. The traditional Chinese medicine compound for treating chronic periodontitis is rich in raw material, rapid in curative effect, the effective rate reaches 100%, and the cure rate is 73%; the vitamin C is extracted purely naturally, safe, healthy and free of toxic or side effect, and the extraction ate is as high as 12.1%; all types of traditional Chinese medicine are extracted and purified multiple times, the yield is raised by 18.7%, and production cost is saved; the traditional Chinese medicine compound is of faint scent and slightly sweet in taste, peculiar smell of traditional Chinese medicine does not exist, a patient cannot have a sense of conflict, the compound is easy to take and can rapidly eliminate inflammation and relive pain, tonify the kidney and protect teeth, regeneration and repair of damaged tissue are promoted, and the purpose of curing periodontitis is achieved.

Description

A kind of Chinese medicine compound treating chronic periodontitis
Technical field
The invention mainly relates to pharmaceutical technology field, particularly relate to a kind of Chinese medicine compound treating chronic periodontitis.
Background technology
Periodontitis is the chronic infective involving four kinds of Periodontal Supporting Tissue (gingiva, periodontal membrane, alveolar bone and cementum) Disease, often causes the inflammatory destruction of Periodontal Supporting Tissue, and periodontitis is broadly divided into chronic periodontitis, aggressive periodontitis, anti- Reflect the periodontitis of general disease, gangrenosum acne periodontal disease.The traditional Chinese medical science is thought, kidney governing bones, tooth being the surplus of the bone, chronic periodontitis with suffered from a deficiency of the kidney Close, should clearing away heat and eliminating dampness, also want the kidney invigorating antiinflammatory.The target of periodontitis treatment is: (1) removes the cause of disease, diminishes inflammation；(2) recover The physiology profile of soft tissue and bone；(3) recover function, keep permanent curative effect；(4) regeneration of periodontal tissue is promoted；(5) U.S. is met Learn and need.The medicine treating periodontitis in the market mostly is Western medicine, but curative effect is the most undesirable, exist cure rate low, Drug effect slowly, easily recur, have the shortcoming of side effect, bring serious body & mind to perplex to patient.
The present invention studies through for many years, and the target of periodontitis treatment is foundation, overcomes existing treatment periodontitis medicine not Foot, develop cure rate height, instant effect, do not recur, have no side effect, the cheap Chinese medicine compound treating periodontitis.
Summary of the invention
In order to make up the defect of prior art, it is an object of the invention to provide a kind of middle recurrence due to taking drug treating chronic periodontitis Side.
A kind of Chinese medicine compound treating chronic periodontitis, is made up of the raw material of following weight portion: Fructus Rhodotyporis scandentis 16 ~ 18, Euphorbia thymifolia 16 ~ 18, Herba Clinopodii megalanthi 15 ~ 17, water cotyledon 13 ~ 15, Radix Pteroxygoni Giraldii 13 ~ 15, tassel velvet flowers 12 ~ 14, Radix Hemsleyae Macrospermae 11 ~ 13, Herba Reineckeae Carneae 11 ~ 13, Lombardy poplar skin 10 ~ 12, Drymaria diandra Blume 10 ~ 12, Ancients Euphorbia Stem 9 ~ 11, high-spirited 9 ~ 11, youth-and-old-age 9 ~ 11, oligofructose 7 ~ 9, Propolis 7 ~ 9, Depositum urinae preparatum 6 ~ 8, Halitum 4 ~ 6, Halloysitum Rubrum 4 ~ 6, cellulase 0.22 ~ 0.26, pectase 0.11 ~ 0.13, coenzyme Q10 powder 0.08 ~ 0.10, vitamin C 0.05 ~ 0.07.
Preferably, the Chinese medicine compound of described treatment chronic periodontitis, it is made up of the raw material of following weight portion: Fructus Rhodotyporis scandentis 18, Euphorbia thymifolia 18, Herba Clinopodii megalanthi 17, water cotyledon 15, Radix Pteroxygoni Giraldii 15, tassel velvet flowers 14, Radix Hemsleyae Macrospermae 13, Herba Reineckeae Carneae 12, Lombardy poplar skin 12, Drymaria diandra Blume 11, Ancients Euphorbia Stem 11, high-spirited 10, youth-and-old-age 10, oligomeric xylose 9, propolis 9, Depositum urinae preparatum 8, Halitum 6, Halloysitum Rubrum 5, fibre Dimension element enzyme 0.24, pectase 0.11, coenzyme Q10 powder 0.08, vitamin C 0.06.
Described vitamin C, takes wheat straw, wooden fork the one in fruit, prickly-pear cactus, green pepper, Fructus actinidiae chinensis and Caulis et Folium Brassicae capitatae or several Kind, to clean, dewatering, obtain vitamin C raw material, the volume fraction adding vitamin C raw material weight 0.6 ~ 0.8 times amount is 2.2 ~ 2.4% Acetum, making beating, cross 100 ~ 120 mesh sieves, the volume fraction adding vitamin C raw material weight 1.2 ~ 1.4 times amount is 1.5 ~ The acetum of 1.7%, airtight, shake extraction 5 ~ 6 hours in 4 DEG C, 54 ~ 56 revs/min, filter, obtain filtrate and filtering residue, repeat Extracting 3 times, merge all filtrate, 8000 revs/min are centrifuged 15 minutes, take supernatant, cross the filter membrane of 0.22 μm, and lyophilization is to nothing Moisture, without toxic reagent, safety and Health, extraction ratio is high, obtains vitamin C.
A kind of preparation method of the Chinese medicine compound treating chronic periodontitis, its concrete steps include:
(1) by Fructus Rhodotyporis scandentis, Euphorbia thymifolia, Herba Clinopodii megalanthi, water cotyledon, Radix Pteroxygoni Giraldii, tassel velvet flowers, Radix Hemsleyae Macrospermae, Herba Reineckeae Carneae, Lombardy poplar skin, lotus Lotus bean grass, Ancients Euphorbia Stem, high-spirited and youth-and-old-age are pulverized, and cross 80 ~ 100 mesh sieves, obtain vegetable material powder, add vegetable material grain weight amount 3 ~ 4 The distilled water of times amount, 42 ~ 44 DEG C of water-baths, add cellulase and pectase, 37 ~ 39 revs/min of stirring enzymolysis 220 ~ 240 points Clock, destroys organization structure of the plant, improves extraction ratio, obtains plant enzymolysis material；
(2) plant enzymolysis material being placed in 90 ~ 95 DEG C of water-baths, the ultrasonic extraction of 36 ~ 38kHz 35 ~ 40 minutes, 5000 revs/min are centrifuged 10 minutes, obtain extracting solution A and plant medicine dregs A, the distilled water of addition plant medicine dregs A weight 2 ~ 3 times amount in plant medicine dregs A, 33 ~ The ultrasonic extraction of 35kHz 25 ~ 30 minutes, 5000 revs/min are centrifuged 10 minutes, obtain extracting solution B and plant medicine dregs B, to plant medicine dregs B The alcoholic solution that volume fraction is 76 ~ 78% of middle addition plant medicine dregs B weight 2 ~ 3 times amount, airtight, 64 ~ 66 DEG C of water-baths, 33 ~ The ultrasonic extraction of 35kHz 25 ~ 30 minutes, 8000 revs/min are centrifuged 10 minutes, obtain extracting solution C and plant medicine dregs C, merge all carrying Take liquid, cross 120 ~ 140 mesh sieves, be placed in 80 ~ 85 DEG C of baking ovens, be concentrated into the 1/3 of original volume, obtain plant extraction liquid；
(3) Depositum urinae preparatum, Halitum and Halloysitum Rubrum are pulverized, cross 80 ~ 100 mesh sieves, obtain stone powder, add the water of stone powder weight 5 ~ 7 times amount, greatly Fire boils, little fire infusion 30 ~ 40 minutes, takes out supernatant, again adds water, and repeats infusion and extracts 3 times, merges all infusion liquid, Cross the filter membrane of 0.45 μm, be concentrated into 2 times of stone powder weight, obtain stone powder extracting solution；
(4) by plant extraction liquid, stone powder extracting solution and propolis mix homogeneously, obtain Chinese medicine extraction liquid, add in Chinese medicine extraction liquid The ether of Chinese medicine extraction liquid volume 1/5 amount, 48 ~ 50 revs/min shake 40 ~ 50 minutes, stand 20 ~ 30 minutes, separate ether layer And water layer, retaining water layer, obtain water layer extracting solution, water layer extracting solution is added in the bag filter that molecular weight is 32kD, flowing water is dialysed 22 ~ 24 hours, take out, be concentrated in vacuo to the 1/2 of all raw material weights in 45 ~ 47 DEG C, add oligofructose, coenzyme Q10 powder and Vitamin C, must treat the Chinese medicine compound of chronic periodontitis；
(5) it is divided into 100 parts, is prepared as preparation, packaging, 36 ~ 38 DEG C, 112 ~ 114MPa ultrahigh-pressure sterilization 20 ~ 25 minutes, must become Product.
The preparation of described step (5), for tablet or spraying liquid.
The Chinese medicine compound of described treatment chronic periodontitis, instructions of taking is three times a day, often eat chew after meal a piece of or to Spray 2 times in Kou.
The invention have the advantage that a kind of Chinese medicine compound treating chronic periodontitis that the present invention provides, abundant raw material, curative effect Quickly, effective percentage is up to 100%, and cure rate is 73%；Raw material is easy to get, cheap, alleviates the financial burden of patient；Vitamin C Extracting through pure natural, safety and Health, have no side effect, extraction ratio is up to 12.1%, increases operation rate；All Chinese medicines are through repeatedly carrying Taking and purification, yield improves 18.7%, saves a large amount of production cost；Fragrant in taste is light sweet, without Chinese medicine abnormal flavour, patient do not have to Sense of touch, uses simple, and patient only need to chew a piece of after meal or spray twice, it is possible to quick antibacterial, and anti-inflammatory analgetic promotes damage group The regeneration knitted and reparation, reach to cure the purpose of chronic periodontitis.
Detailed description of the invention
With specific embodiment, the present invention is described below.
Embodiment 1
A kind of Chinese medicine compound treating chronic periodontitis, is made up of the raw material of following weight portion: Fructus Rhodotyporis scandentis 18, Euphorbia thymifolia 18, very little gold Grass 17, water cotyledon 15, Radix Pteroxygoni Giraldii 15, tassel velvet flowers 14, Radix Hemsleyae Macrospermae 13, Herba Reineckeae Carneae 12, Lombardy poplar skin 12, Drymaria diandra Blume 11, fire Calamity Le 11, high-spirited 10, youth-and-old-age 10, oligomeric xylose 9, propolis 9, Depositum urinae preparatum 8, Halitum 6, Halloysitum Rubrum 5, cellulase 0.24, really Glue enzyme 0.11, coenzyme Q10 powder 0.08, vitamin C 0.06.
Described vitamin C, takes wheat straw, wooden fork the one in fruit, prickly-pear cactus, green pepper, Fructus actinidiae chinensis and Caulis et Folium Brassicae capitatae or several Kind, to clean, dewatering, obtain vitamin C raw material, the acetic acid that volume fraction is 2.4% adding vitamin C raw material weight 0.8 times amount is molten Liquid, making beating, cross 120 mesh sieves, add the acetum that volume fraction is 1.7% of vitamin C raw material weight 1.4 times amount, airtight, In 4 DEG C, 56 revs/min of concussion extractions 6 hours, filter, obtain filtrate and filtering residue, repeat to extract 3 times, merge all filtrate, 8000 Revs/min centrifugal 15 minutes, taking supernatant, cross the filter membrane of 0.22 μm, lyophilization is to without moisture, without toxic reagent, and safety and Health, Extraction ratio is high, obtains vitamin C.
A kind of preparation method of the Chinese medicine compound treating chronic periodontitis, its concrete steps include:
(1) by Fructus Rhodotyporis scandentis, Euphorbia thymifolia, Herba Clinopodii megalanthi, water cotyledon, Radix Pteroxygoni Giraldii, tassel velvet flowers, Radix Hemsleyae Macrospermae, Herba Reineckeae Carneae, Lombardy poplar skin, lotus Lotus bean grass, Ancients Euphorbia Stem, high-spirited and youth-and-old-age are pulverized, and cross 100 mesh sieves, obtain vegetable material powder, add vegetable material grain weight amount 4 times amount Distilled water, 44 DEG C of water-baths, add cellulase and pectase, 39 revs/min are stirred enzymolysis 240 minutes, destroy plant tissue knot Structure, improves extraction ratio, obtains plant enzymolysis material；
(2) plant enzymolysis material is placed in 95 DEG C of water-baths, the ultrasonic extraction of 38kHz 40 minutes, 5000 revs/min are centrifuged 10 minutes, Extracting solution A and plant medicine dregs A, adds the distilled water of plant medicine dregs A weight 3 times amount, the ultrasonic extraction of 35kHz in plant medicine dregs A 30 minutes, 5000 revs/min were centrifuged 10 minutes, obtain extracting solution B and plant medicine dregs B, added plant medicine dregs B in plant medicine dregs B The alcoholic solution that volume fraction is 78% of weight 2 ~ 3 times amount, airtight, 66 DEG C of water-baths, the ultrasonic extraction of 35kHz 30 minutes, 8000 Revs/min centrifugal 10 minutes, obtain extracting solution C and plant medicine dregs C, merge all extracting solution, cross 140 mesh sieves, be placed in 85 DEG C of baking ovens, It is concentrated into the 1/3 of original volume, obtains plant extraction liquid；
(3) Depositum urinae preparatum, Halitum and Halloysitum Rubrum being pulverized, cross 100 mesh sieves, obtain stone powder, add the water of stone powder weight 7 times amount, big fire is boiled Boiling, little fire infusion 40 minutes, take out supernatant, again add water, repeat infusion and extract 3 times, merge all infusion liquid, cross 0.45 μm Filter membrane, be concentrated into 2 times of stone powder weight, obtain stone powder extracting solution；
(4) by plant extraction liquid, stone powder extracting solution and propolis mix homogeneously, obtain Chinese medicine extraction liquid, add in Chinese medicine extraction liquid The ether of Chinese medicine extraction liquid volume 1/5 amount, 50 revs/min shake 45 minutes, stand 30 minutes, separate ether layer and water layer, protect Staying water layer, obtain water layer extracting solution, added in the bag filter that molecular weight is 32kD by water layer extracting solution, flowing water is dialysed 22 hours, takes Go out, be concentrated in vacuo to the 1/2 of all raw material weights in 45 DEG C, add oligofructose, coenzyme Q10 powder and vitamin C, must treat slow The Chinese medicine compound of property periodontitis；
(5) it is divided into 100 parts, is prepared as tablet, packaging, 36 DEG C, 112MPa ultrahigh-pressure sterilization 25 minutes, obtain finished product.
The Chinese medicine compound of described treatment chronic periodontitis, instructions of taking is three times a day, and often eating, it is a piece of to chew after meal.
Embodiment 2
A kind of Chinese medicine compound treating chronic periodontitis, is made up of the raw material of following weight portion: Fructus Rhodotyporis scandentis 18, Euphorbia thymifolia 18, very little gold Grass 17, water cotyledon 15, Radix Pteroxygoni Giraldii 15, tassel velvet flowers 14, Radix Hemsleyae Macrospermae 13, Herba Reineckeae Carneae 13, Lombardy poplar skin 12, Drymaria diandra Blume 12, fire Calamity Le 11, high-spirited 11, youth-and-old-age 11, oligofructose 9, propolis 9, Depositum urinae preparatum 8, Halitum 6, Halloysitum Rubrum 6, cellulase 0.26, really Glue enzyme 0.13, coenzyme Q10 powder 0.10, vitamin C 0.07.
Preparation method, with embodiment 1, makes spraying liquid, three times a day, and spraying 2 times after meal of often eating.
Comparative example
The medicine of commercially available current therapies chronic periodontitis.
Embodiment and the fungistatic effect of comparative example medicament:
Example and the medicament 100 of comparative example respectively, adds the distilled water diluting of equivalent, mix homogeneously, adds color Rou Shi spiral shell Rotation body, expectorant spirillum, candida mycoderma, streptococcus anaerobius and alpha streptococcus culture dish in, carry out bacteriostatic test, cultivate 12 ~ 14 hours, the diameter of vernier caliper measurement inhibition zone, the fungistatic effect of embodiment and comparative example medicament is utilized to be shown in Table 1.
Table 1: embodiment and the fungistatic effect of comparative example medicament
As it can be seen from table 1 the Chinese medicine compound of the treatment chronic periodontitis of embodiment, act on color Rou Shi spirillum, expectorant spiral Bacterium, candida mycoderma, streptococcus anaerobius and alpha streptococcus, each antibacterial antibacterial circle diameter of embodiment is all significantly greater than comparative example, The inhibition of antibacterial is substantially better than comparative example, illustrates that the Chinese medicine compound of embodiment treatment chronic periodontitis has the most antibacterial Effect.
Embodiment and the effect of comparative example pharmaceutical treatment chronic periodontitis:
Usage and dosage: three times a day, often eats and chews 1 after meal, uses 15 days continuously.
Test case:
Curative effect determinate standard:
Effective: periodontitis area reduces, and hemorrhage, red and swollen and pain symptom alleviates, and has taken a turn for the better；
Curing: periodontitis area disappears, hemorrhage, red and swollen and pain symptom disappears.
Randomly choosing patient 200 example, the standard of selection is: meet Western medicine diagnose standard and differential diagnosis in tcm standard, age exist Between 18 ~ 55 years old, wherein, women 100 example, male 100 example.Above-mentioned case is divided into embodiment group and comparative example group, respectively at random 100 people, men and women half and half, and the effect of embodiment and comparative example pharmaceutical treatment chronic periodontitis is shown in Table 2.
Table 2: embodiment and the effect of comparative example pharmaceutical treatment chronic periodontitis
Project Patient's number Effectively/(%) Cure/(%) Onset time/(hour)
Embodiment group 100 100 73 3
Comparative example group 100 88 61 2
From table 2 it can be seen that the Chinese medicine compound of the treatment chronic periodontitis of embodiment, the effective percentage of embodiment is 100%, cures Rate is 73%, and action effect is fast, illustrates that the Chinese medicine compound of embodiment treatment chronic periodontitis has and significantly treats chronic periodontitis Effect.

Claims (6)

1. the Chinese medicine compound treating chronic periodontitis, it is characterised in that be made up of the raw material of following weight portion: Fructus Rhodotyporis scandentis 16 ~ 18, Euphorbia thymifolia 16 ~ 18, Herba Clinopodii megalanthi 15 ~ 17, water cotyledon 13 ~ 15, Radix Pteroxygoni Giraldii 13 ~ 15, tassel velvet flowers 12 ~ 14, Radix Hemsleyae Macrospermae 11 ~ 13, Herba Reineckeae Carneae 11 ~ 13, Lombardy poplar skin 10 ~ 12, Drymaria diandra Blume 10 ~ 12, Ancients Euphorbia Stem 9 ~ 11, high-spirited 9 ~ 11, youth-and-old-age 9 ~ 11, oligomeric Fructose 7 ~ 9, propolis 7 ~ 9, Depositum urinae preparatum 6 ~ 8, Halitum 4 ~ 6, Halloysitum Rubrum 4 ~ 6, cellulase 0.22 ~ 0.26, pectase 0.11 ~ 0.13, Coenzyme Q10 powder 0.08 ~ 0.10, vitamin C 0.05 ~ 0.07.
The Chinese medicine compound for the treatment of chronic periodontitis the most according to claim 1, it is characterised in that former by following weight portion Material is made: Fructus Rhodotyporis scandentis 18, Euphorbia thymifolia 18, Herba Clinopodii megalanthi 17, water cotyledon 15, Radix Pteroxygoni Giraldii 15, tassel velvet flowers 14, Radix Hemsleyae Macrospermae 13, Herba Reineckeae Carneae 12, Lombardy poplar skin 12, Drymaria diandra Blume 11, Ancients Euphorbia Stem 11, high-spirited 10, youth-and-old-age 10, oligomeric xylose 9, propolis 9, Depositum urinae preparatum 8, green grass or young crops Salt 6, Halloysitum Rubrum 5, cellulase 0.24, pectase 0.11, coenzyme Q10 powder 0.08, vitamin C 0.06.
The Chinese medicine compound for the treatment of chronic periodontitis the most according to claim 1, it is characterised in that described vitamin C, takes Wheat straw, wooden fork, one or more in fruit, prickly-pear cactus, green pepper, Fructus actinidiae chinensis and Caulis et Folium Brassicae capitatae, are cleaned, dewatering, are obtained vitamin C former Material, adds the acetum that volume fraction is 2.2 ~ 2.4% of vitamin C raw material weight 0.6 ~ 0.8 times amount, pulls an oar, excessively 100 ~ 120 mesh sieves, add the acetum that volume fraction is 1.5 ~ 1.7% of vitamin C raw material weight 1.2 ~ 1.4 times amount, airtight, in 4 DEG C, 54 ~ 56 revs/min of concussion extractions 5 ~ 6 hours, filter, obtain filtrate and filtering residue, repeat to extract 3 times, merge all filtrate, 8000 revs/min are centrifuged 15 minutes, take supernatant, cross the filter membrane of 0.22 μm, and lyophilization, to without moisture, obtains vitamin C.
Treat the preparation method of chronic periodontitis Chinese medicine compound the most according to claim 1, it is characterised in that include following step Rapid:
(1) by Fructus Rhodotyporis scandentis, Euphorbia thymifolia, Herba Clinopodii megalanthi, water cotyledon, Radix Pteroxygoni Giraldii, tassel velvet flowers, Radix Hemsleyae Macrospermae, Herba Reineckeae Carneae, Lombardy poplar skin, lotus Lotus bean grass, Ancients Euphorbia Stem, high-spirited and youth-and-old-age are pulverized, and cross 80 ~ 100 mesh sieves, obtain vegetable material powder, add vegetable material grain weight amount 3 ~ 4 The distilled water of times amount, 42 ~ 44 DEG C of water-baths, add cellulase and pectase, 37 ~ 39 revs/min of stirring enzymolysis 220 ~ 240 points Clock, obtains plant enzymolysis material；
(2) plant enzymolysis material being placed in 90 ~ 95 DEG C of water-baths, the ultrasonic extraction of 36 ~ 38kHz 35 ~ 40 minutes, 5000 revs/min are centrifuged 10 minutes, obtain extracting solution A and plant medicine dregs A, the distilled water of addition plant medicine dregs A weight 2 ~ 3 times amount in plant medicine dregs A, 33 ~ The ultrasonic extraction of 35kHz 25 ~ 30 minutes, 5000 revs/min are centrifuged 10 minutes, obtain extracting solution B and plant medicine dregs B, to plant medicine dregs B The alcoholic solution that volume fraction is 76 ~ 78% of middle addition plant medicine dregs B weight 2 ~ 3 times amount, airtight, 64 ~ 66 DEG C of water-baths, 33 ~ The ultrasonic extraction of 35kHz 25 ~ 30 minutes, 8000 revs/min are centrifuged 10 minutes, obtain extracting solution C and plant medicine dregs C, merge all carrying Take liquid, cross 120 ~ 140 mesh sieves, be placed in 80 ~ 85 DEG C of baking ovens, be concentrated into the 1/3 of original volume, obtain plant extraction liquid；
(3) Depositum urinae preparatum, Halitum and Halloysitum Rubrum are pulverized, cross 80 ~ 100 mesh sieves, obtain stone powder, add the water of stone powder weight 5 ~ 7 times amount, greatly Fire boils, little fire infusion 30 ~ 40 minutes, takes out supernatant, again adds water, and repeats infusion and extracts 3 times, merges all infusion liquid, Cross the filter membrane of 0.45 μm, be concentrated into 2 times of stone powder weight, obtain stone powder extracting solution；
(4) by plant extraction liquid, stone powder extracting solution and propolis mix homogeneously, obtain Chinese medicine extraction liquid, add in Chinese medicine extraction liquid The ether of Chinese medicine extraction liquid volume 1/5 amount, 48 ~ 50 revs/min shake 40 ~ 50 minutes, stand 20 ~ 30 minutes, separate ether layer And water layer, retaining water layer, obtain water layer extracting solution, water layer extracting solution is added in the bag filter that molecular weight is 32kD, flowing water is dialysed 22 ~ 24 hours, take out, be concentrated in vacuo to the 1/2 of all raw material weights in 45 ~ 47 DEG C, add oligofructose, coenzyme Q10 powder and Vitamin C, must treat the Chinese medicine compound of chronic periodontitis；
(5) it is divided into 100 parts, is prepared as preparation, packaging, 36 ~ 38 DEG C, 112 ~ 114MPa ultrahigh-pressure sterilization 20 ~ 25 minutes, must become Product.
Treat the preparation method of the Chinese medicine compound of chronic periodontitis the most according to claim 1, it is characterised in that described step (5) preparation, for tablet or spraying liquid.
6. according to the instructions of taking of the Chinese medicine compound of the treated chronic periodontitis of claim 1 ~ 5, it is characterised in that three times a day, Often eat and chew a piece of after meal or spray 2 times in mouth.
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CN108743779A (en) * 2018-07-30 2018-11-06 佛山科学技术学院 A kind of traditional Chinese herbal decoction and preparation method thereof for treating periodontitis
CN111454153A (en) * 2019-01-18 2020-07-28 南开大学 Five ent-tisane diterpene compounds from euphorbia humifusa and preparation method and application thereof

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Publication number Priority date Publication date Assignee Title
CN108743779A (en) * 2018-07-30 2018-11-06 佛山科学技术学院 A kind of traditional Chinese herbal decoction and preparation method thereof for treating periodontitis
CN111454153A (en) * 2019-01-18 2020-07-28 南开大学 Five ent-tisane diterpene compounds from euphorbia humifusa and preparation method and application thereof
CN111454153B (en) * 2019-01-18 2023-01-31 南开大学 Five ent-tisane diterpene compounds from euphorbia humifusa and preparation method and application thereof

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