CN105963862A - Needle-shaped photodynamic therapeutic device - Google Patents
Needle-shaped photodynamic therapeutic device Download PDFInfo
- Publication number
- CN105963862A CN105963862A CN201610247154.XA CN201610247154A CN105963862A CN 105963862 A CN105963862 A CN 105963862A CN 201610247154 A CN201610247154 A CN 201610247154A CN 105963862 A CN105963862 A CN 105963862A
- Authority
- CN
- China
- Prior art keywords
- needle
- closing member
- nook closing
- insulating film
- electrical insulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract description 8
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 23
- 230000001678 irradiating effect Effects 0.000 claims abstract description 5
- 230000003287 optical effect Effects 0.000 claims description 20
- 239000004020 conductor Substances 0.000 claims description 3
- 231100000252 nontoxic Toxicity 0.000 claims description 3
- 230000003000 nontoxic effect Effects 0.000 claims description 3
- 239000000919 ceramic Substances 0.000 claims description 2
- 238000009413 insulation Methods 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 abstract description 12
- 239000000463 material Substances 0.000 abstract description 9
- 238000011282 treatment Methods 0.000 abstract description 9
- 239000013307 optical fiber Substances 0.000 abstract description 3
- 230000000149 penetrating effect Effects 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 238000002428 photodynamic therapy Methods 0.000 description 6
- 239000003504 photosensitizing agent Substances 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000004020 luminiscence type Methods 0.000 description 2
- 230000004899 motility Effects 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 206010067193 Naevus flammeus Diseases 0.000 description 1
- 208000006787 Port-Wine Stain Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000009455 aseptic packaging Methods 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005401 electroluminescence Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 208000002026 familial multiple nevi flammei Diseases 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N2005/0612—Apparatus for use inside the body using probes penetrating tissue; interstitial probes
Landscapes
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention provides a needle-shaped photodynamic therapeutic device, which comprises an electroluminescent needle core, a transparent electrical insulating film arranged at the outer surface of the needle core in a sleeved manner, and a conductive wire connected with the needle core, and is characterized in that the needle core comprises a needle bar and a needle tip, the electrical insulating film completely covers the needle core and is consistent with the shape of a needle, the whole needle core emits light after being electrified and irradiates a diseased part through the electrical insulating film, and the needle core is a non-transparent rigid needle core. According to the invention, the electroluminescent needle core is adopted, and the needle core can emit light after being electrified and irradiates the diseased part in a large-area manner after penetrating through the transparent electrical insulating film. Compared with a traditional laser light source, the electroluminescent material is lower in cost, more flexible in irradiation area and capable of irradiating deep or shallow; the needle-shaped photodynamic therapeutic device does not need optical fiber conduction light, but adopts the electroluminescent rigid needle core, thereby being not easy to be broken or crushed, good in stability and more beneficial for the efficiency and the safety of tumor therapy; and the needle-shaped photodynamic therapeutic device can emit light by being only electrified so as to carry out treatment, thereby being more convenient for implementation compared with treatment taking laser as a light source.
Description
Technical field
The invention belongs to technical field of medical instruments, particularly to a kind of aciculiform optical dynamic therapy device.
Background technology
The principle of photodynamic therapy (photodynamic therapy, PDT) treatment malignant tumor is: during treatment,
Photosensitizer is injected blood vessel, when it accumulates a certain amount of at lesion, shines with a kind of specific laser
Penetrating pathological changes to be activated by photosensitizer, the photosensitizer of activation discharges substantial amounts of free radical and singlet oxygen, destroys pathological changes
Tissue cellularity, may result in tumor tissue necrosis's atrophy, reaches therapeutic purposes.This therapy be continue operation,
The fast-developing brand-new therapy risen after radiotherapy, chemotherapy and immunization therapy, has specificity high, wound
Little feature, it has also become one of most active research field in world's treatment and prevention of tumour science.But, due to carefully
The restriction to the penetration depth of light of born of the same parents' tissue, the effective interaction depth in PDT light source is difficult to exceed several centimetres.This
It is its advantage, is also its inferior position.It is the disease of shallow structure for target tissue, such as skin, mucosa
The diseases such as superficial tumor, nevus flammeus, macular degeneration, atherosclerosis and psoriasis, light moves
Power treatment can well damage shallow-layer target body, and does not destroy normal structure.But, for deep tumor or
The tumor that tumor body is bigger, directly applies PDT, and light is difficult to go deep into inside tumor and then eliminate tumor.Therefore,
Optical dynamic therapy is had a major impact by the development of light source and guide instrument.As various shape optical fiber appearance more
Conveniently treat variously-shaped pathological changes.But there is frangible easily broken feature in optical fiber, has certain
Unstable factor.And the light source that PDT mainly uses at present is laser instrument, relatively costly.So, according to
Clinical need, optimize illumination parameter, develop certain operations simple, it is easy to use, output is stable and price just
Suitable equipment need to carry out.
Summary of the invention
Present invention is primarily targeted at provides a kind of energy deep enough deeper or the aciculiform light of bigger inside tumor moves
Power therapeutic apparatus, it is intended to improve the stability of therapeutic apparatus itself, convenient to operate and reduction cost.
The present invention is achieved in that a kind of aciculiform optical dynamic therapy device, including electroluminescent nook closing member, set
It is located at the transparent electrical insulating film of described nook closing member outer surface, and the conductor wire being connected with described nook closing member, described
Nook closing member includes that shank and needle point, described shank and needle point are structure as a whole, and described electrical insulating film is coated with institute completely
Stating nook closing member and consistent with described nook closing member shape, Integral luminous after the energising of described nook closing member, this light passes through described electricity
Irradiating diseased region after dielectric film, described nook closing member is nontransparent rigidity nook closing member.
The present invention uses electroluminescent nook closing member, can be luminous after its energising, big after transparent electrical insulating film
The irradiation diseased region of area, for traditional LASER Light Source, electroluminescent material cost is lower,
And irradiated area relatively LASER Light Source to irradiate motility higher, and can deeply can be shallow；Need not fiber optic conduction light,
And use electroluminescent rigidity nook closing member, and it being not easily broken and crush, good stability, for the efficiency of oncotherapy
The most useful with safety；And only need energising luminescence to treat, relatively the treatment with laser as light source
It is more convenient for implementing.
Accompanying drawing explanation
Fig. 1 is the structural representation of the aciculiform optical dynamic therapy device that the embodiment of the present invention provides；
Fig. 2 is a kind of needle point structure schematic diagram of the aciculiform optical dynamic therapy device that the embodiment of the present invention provides；
Fig. 3 is the another kind of needle point structure schematic diagram of the aciculiform optical dynamic therapy device that the embodiment of the present invention provides.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with accompanying drawing and reality
Execute example, the present invention is further elaborated.Only should be appreciated that specific embodiment described herein
Only in order to explain the present invention, it is not intended to limit the present invention.
It should be noted that when element is referred to as " being fixed on " or " being arranged at " another element, and it can be straight
It is connected on another element or is connected on this another element.When an element is referred to as " being connected to " separately
One element, it can be directly to another element or be indirectly connected to this another element.
Also, it should be noted the orientation term such as left and right, upper and lower in the embodiment of the present invention, it is only mutual
For relative concept or with the normal operating condition of product as reference, and should not be regarded as restrictive
's.
Referring to accompanying drawing 1, the present invention provides a kind of aciculiform optical dynamic therapy device, be used for going deep into position relatively deep or
The inside of the bigger tumor of person, the photosensitizer of its luminous gathering irradiating diseased region to carry out optical dynamic therapy,
This aciculiform optical dynamic therapy device includes the nook closing member 01 made by electroluminescent material, is sheathed on nook closing member 01 appearance
The transparent electrical insulating film 02 in face, and the conductor wire 04 drawn by external power source 03 being connected with nook closing member 01,
This nook closing member 01 is nontransparent rigidity nook closing member, and it includes shank 011 and needle point 012, shank 011 and needle point
012 is structure as a whole, and this electrical insulating film 02 is coated on the outside of nook closing member 01 completely, for protection nook closing member
01 and isolate nook closing member 01 and tissue, simultaneously the smooth surface of electrical insulating film 02 and hardness relatively big so that
Inserting internal, it addition, the shape of electrical insulating film 02 is consistent with the shape of nook closing member 01, especially its tip is relatively
For sharp-pointed so that inserting inside tumor.Owing to this nook closing member 01 is made by electroluminescent material, can after its energising
With Integral luminous, this light, through irradiating diseased region after electrical insulating film 02, carries out large-area irradiation, makes
The photosensitizer generation optical sensibilization that diseased region is assembled, produces the effect of killing tumor cell, it is achieved treatment
Purpose.In actual therapeutic, the selection of electroluminescent material is mated according to the photosensitizer used, should
Aciculiform optical dynamic therapy device is disposable product.
The embodiment of the present invention uses the nook closing member 01 that electroluminescent material makes, luminous through transparent after its energising
After electrical insulating film 02, large area irradiates diseased region, for traditional LASER Light Source, electroluminescence material
Material cost is lower, and the irradiation motility of irradiated area relatively LASER Light Source is higher；Need not fiber optic conduction light,
And use electroluminescent rigidity nook closing member 01, and it being not easily broken and crush, good stability, for the effect of oncotherapy
Rate and safety are the most useful；And only need energising luminescence to treat, relatively controlling with laser as light source
Treatment is more convenient for implementing.
Further, the electrical insulating film 02 that the present embodiment uses is nontoxic organic ceramic electrical insulating film, environmental protection,
Transparent, to human non-toxic's side effect.It addition, nook closing member 01 selects, mechanical strength is relatively strong, luminous efficiency is higher
Electroluminescent material makes, and had both ensured its intensity of illumination, and had ensured again its rigidity, be not easily broken.
Further, in the present embodiment, the entire outer diameter scope of aciculiform optical dynamic therapy device is 0.03～5mm,
Being preferably 1～3mm, wherein, the wall thickness range of electrical insulating film 02 is 0.01-1mm, preferably 0.25～1mm,
It is 0.02-2mm in the diametric total thickness of needle body, preferably 0.5～2mm, the shank of nook closing member 01
The diameter range at 011 position is 0.01-3mm, preferably 1～2.5mm, to ensure that electrical insulating film 02 can
Sufficiently protection nook closing member 01, and make the rigidity of nook closing member 01 and luminous intensity meet requirement, needle body is straight simultaneously
Footpath is avoided excessive.
In the present embodiment, the structure of needle point 012 can be, but not limited to use the following two kinds structure, such as Fig. 2
And Fig. 3, the first is by the tapered tip formed of the end of shank 011, and outward appearance is cone, can be straight
Circular cone, it is also possible to be oblique cone.Its two be chamfered by the end of shank 011 after the tip that formed, outward appearance
It it is the shape that intersects of an inclined-plane and shank 011 side.Other can also be used in other embodiments rational
Structure.
Further, in order to prevent aciculiform optical dynamic therapy device to be contaminated, also in the outer cover of electrical insulating film 02
It is provided with needle cap 05, and carries out aseptic packaging, take apart during operation after packaging takes off needle cap 05 sterilization and use.
These are only presently preferred embodiments of the present invention, not in order to limit the present invention, all the present invention's
Any amendment, equivalent or the improvement etc. made within spirit and principle, should be included in the guarantor of the present invention
Within the scope of protecting.
Claims (6)
1. an aciculiform optical dynamic therapy device, it is characterised in that include electroluminescent nook closing member, be sheathed on
The transparent electrical insulating film of described nook closing member outer surface, and the conductor wire being connected with described nook closing member, described nook closing member
Including shank and needle point, described shank and needle point are structure as a whole, and described electrical insulating film is coated with described pin completely
Core and consistent with described nook closing member shape, Integral luminous after the energising of described nook closing member, this light passes through described electric insulation
Irradiating diseased region after film, described nook closing member is nontransparent rigidity nook closing member.
2. aciculiform optical dynamic therapy device as claimed in claim 1, it is characterised in that described electrical insulating film is
Nontoxic organic ceramic electrical insulating film.
3. aciculiform optical dynamic therapy device as claimed in claim 1 or 2, it is characterised in that described electric insulation
The wall thickness range of film is 0.01-1mm, is 0.02-2mm in its diametric total thickness, described pin
The diameter range of the needle bar position of core is 0.01-3mm.
4. aciculiform optical dynamic therapy device as claimed in claim 1 or 2, it is characterised in that described needle point is
By the tapered tip formed of the end of described shank.
5. aciculiform optical dynamic therapy device as claimed in claim 1 or 2, it is characterised in that described needle point is
The tip formed after being chamfered by the end of described shank.
6. aciculiform optical dynamic therapy device as claimed in claim 1 or 2, it is characterised in that described electric insulation
The outer cover of film is provided with needle cap.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610247154.XA CN105963862A (en) | 2016-04-20 | 2016-04-20 | Needle-shaped photodynamic therapeutic device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610247154.XA CN105963862A (en) | 2016-04-20 | 2016-04-20 | Needle-shaped photodynamic therapeutic device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105963862A true CN105963862A (en) | 2016-09-28 |
Family
ID=56993779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610247154.XA Pending CN105963862A (en) | 2016-04-20 | 2016-04-20 | Needle-shaped photodynamic therapeutic device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105963862A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5445608A (en) * | 1993-08-16 | 1995-08-29 | James C. Chen | Method and apparatus for providing light-activated therapy |
| US5814008A (en) * | 1996-07-29 | 1998-09-29 | Light Sciences Limited Partnership | Method and device for applying hyperthermia to enhance drug perfusion and efficacy of subsequent light therapy |
| CN1217638A (en) * | 1996-03-07 | 1999-05-26 | 光科技合伙人有限公司 | Flexible microcircuits for internal light therapy |
| US20020010500A1 (en) * | 1998-06-24 | 2002-01-24 | Light Sciences Corporation | Application of light at plural treatment sites within a tumor to increase the efficacy of light therapy |
| CN2588945Y (en) * | 2002-12-10 | 2003-12-03 | 深圳市微创医学科技有限公司 | Special-purpose puncturing needle for tissue irradiation optical power-driven treatment |
| CN201618327U (en) * | 2010-03-04 | 2010-11-03 | 王文君 | Photodynamic puncture tumor treatment instrument |
| CN205759152U (en) * | 2016-04-20 | 2016-12-07 | 深圳市第二人民医院 | A kind of aciculiform optical dynamic therapy device |
-
2016
- 2016-04-20 CN CN201610247154.XA patent/CN105963862A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5445608A (en) * | 1993-08-16 | 1995-08-29 | James C. Chen | Method and apparatus for providing light-activated therapy |
| CN1217638A (en) * | 1996-03-07 | 1999-05-26 | 光科技合伙人有限公司 | Flexible microcircuits for internal light therapy |
| US5814008A (en) * | 1996-07-29 | 1998-09-29 | Light Sciences Limited Partnership | Method and device for applying hyperthermia to enhance drug perfusion and efficacy of subsequent light therapy |
| US20020010500A1 (en) * | 1998-06-24 | 2002-01-24 | Light Sciences Corporation | Application of light at plural treatment sites within a tumor to increase the efficacy of light therapy |
| CN2588945Y (en) * | 2002-12-10 | 2003-12-03 | 深圳市微创医学科技有限公司 | Special-purpose puncturing needle for tissue irradiation optical power-driven treatment |
| CN201618327U (en) * | 2010-03-04 | 2010-11-03 | 王文君 | Photodynamic puncture tumor treatment instrument |
| CN205759152U (en) * | 2016-04-20 | 2016-12-07 | 深圳市第二人民医院 | A kind of aciculiform optical dynamic therapy device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Fried et al. | Noncontact stimulation of the cavernous nerves in the rat prostate using a tunable-wavelength thulium fiber laser | |
| EP1541091A1 (en) | Device for treating tumors by laser thermotherapy | |
| KR100792513B1 (en) | Extracorporeal radial shock wave medical device | |
| Lee et al. | Wireless metronomic photodynamic therapy | |
| CN103170064A (en) | Integral probe for diagnosis and treatment | |
| KR20160137893A (en) | Endoscope probe for sono-photo dynamic therapy | |
| CN112516462B (en) | Photoelectric combined instrument and photodynamic therapeutic apparatus | |
| CN205759152U (en) | A kind of aciculiform optical dynamic therapy device | |
| TWM300116U (en) | Laser wrinkle removing device | |
| US20140074195A1 (en) | Apparatus for delivering multiple forms of electromagnetic radiation and method for its use | |
| CN203220691U (en) | Laser photodynamic therapeutic instrument | |
| CN106902468B (en) | Rectal suppository LED light source for rectal cancer photodynamic therapy | |
| US20110009464A1 (en) | Immune system stimulation by light therapy induced apoptotic cell death in abnormal tissue | |
| EP2394700A1 (en) | Device for irradiating tissue | |
| KR100893761B1 (en) | A light treatment apparatus for capsule type | |
| KR200453658Y1 (en) | Massage tool for low level laser therapy | |
| CN105963862A (en) | Needle-shaped photodynamic therapeutic device | |
| CN112451862B (en) | Photodynamic therapy system and control method thereof | |
| CN204307223U (en) | With the laser power therapeutic instrument of oxygen pipe | |
| KR102155838B1 (en) | Medical light diffusion implant | |
| CN202376642U (en) | Optical quantum instrument | |
| KR100633430B1 (en) | therapy device using near infrared light emitting diode | |
| CN220608885U (en) | Wireless implantable photodynamic microparticles for tumor treatment | |
| KR200345466Y1 (en) | therapy device using near infrared light emitting diode | |
| KR20070106872A (en) | Medical device for treating prostate and perineal region by using a light emitting diode or a laser diode |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160928 |
|
| RJ01 | Rejection of invention patent application after publication |