CN105963758A - Medical membrane with anti-inflammation and antibacterial effects - Google Patents

Medical membrane with anti-inflammation and antibacterial effects Download PDF

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Publication number
CN105963758A
CN105963758A CN201610394258.3A CN201610394258A CN105963758A CN 105963758 A CN105963758 A CN 105963758A CN 201610394258 A CN201610394258 A CN 201610394258A CN 105963758 A CN105963758 A CN 105963758A
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China
Prior art keywords
parts
antibacterial effect
medical film
medical
antiphlogistic antibacterial
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CN201610394258.3A
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Chinese (zh)
Inventor
董芬芳
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Huzhou Guoxin Materials Co Ltd
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Huzhou Guoxin Materials Co Ltd
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Priority to CN201610394258.3A priority Critical patent/CN105963758A/en
Publication of CN105963758A publication Critical patent/CN105963758A/en
Withdrawn legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28Polysaccharides or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41Anti-inflammatory agents, e.g. NSAIDs

Abstract

The invention discloses a medical membrane with the anti-inflammation and antibacterial effects. The medical membrane is prepared from, by weight, 30-50 parts of polyester fiber, 15-20 parts of gelatin, 5-12 parts of sodium alginate, 3-8 parts of cellulose, 6-9 parts of polyurethane carboxyl carbonate, 3-7 parts of ethyl acetate, 10-20 parts of agastache rugosa, 11-14 parts of sanguisorba officinalis, 2-5 parts of glutamic acid, 3-6 parts of laurocapram, 3-8 parts of metronidazole, 3-5 parts of zinc oxide and 5-10 parts of sodium carboxymethyl cellulose. The medical membrane has the anti-inflammation and antibacterial effects, and is good in biocompatibility and histocompatibility, free of irritation on tissue, good in elasticity, good in air-permeable effect, small in skin irritation and free of toxin and harm to human bodies.

Description

A kind of medical film with antiphlogistic antibacterial effect
Technical field
The invention belongs to biomedical materials field, be specifically related to a kind of medical film with antiphlogistic antibacterial effect.
Background technology
Biomaterial is for tissue and the diagnosis of organ, the class High-tech Material repairing or promoting its function, is i.e. used for replacing, repairing living tissue natural or artificial material, and its drugs with function is irreplaceable.Biomaterial can perform, promote or replace certain function lost because of disease, damage etc., and can not recover rejected region.Since the later stage nineties, world's biomaterial Science and Technology develops rapidly, even if under the overall situation that current global economy is low, biomaterial still remains annual 13% rapid growth, has fully demonstrated its powerful vitality and vast potential for future development.Modern medicine forward regeneration and rebuild impaired tissue and organ, recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment and develop.The conventional materials such as traditional abiotic medical metal, macromolecule, bioceramic can not meet the requirement of medical development, and biomedical material scientific and engineering is faced with new opportunities and challenges.In future, medicine may well will be caught up with in the market share of bio-medical material.Therefore, strengthen the clinical application research of bio-medical material and popularization and application, give priority to China's bio-medical material research, develop, produce, the integrated system combined closely of marketing is the task of top priority.Actually, country currently has been achieved for important breakthrough progress in terms of biomaterial scientific basic research, walks in world's rank of advanced units, but industrialization level waits to improve, industry size is little, development relatively lags behind, and is not met by being actually needed of Medicare health care.Under national policy, economic support energetically, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen the ability of autonomous innovation, solves to rely on the situation of import further, adds large outlet dynamics, it is achieved spanning development simultaneously, expands Chinese biological material product power of influence in the world.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial includes metal material (such as alkali metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyapatite etc.) and organic material three major types.Being mainly polymeric set laminate material in organic material, macromolecular material is generally divided into synthesis macromolecular material (polyurethane, polyester, polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber etc.), natural macromolecular material (such as collagen, fibroin, cellulose, chitosan etc.) by material properties;Purposes according to material, these materials can be divided into again biologically inert (bioinert), biological activity (bioactive) or biodegradation (biodegradable) material, in high molecular polymer, can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again Bioabsorbable and biological nonabsorable.Blood compatible polymer and blood incompatibility then it is divided into according to the state that affects on blood constituent, performance after material and contacting blood.To the affinity of body cell and report situations according to material, biocompatibility and bio-incompatibility polymer etc. can be divided into.Medical film just belongs to the one in macromolecular material, and medical film is a kind of healthy prevention equipment that hospital uses when performing the operation.Medical film plays vital effect in surgical operation; it acts not only as skin recovery film for medical use, wound surface dressing and burns I, II degree of minor scratches, little area and less wound is repaired, during operation the protection of otch and chap, the preventing and treating of decubital ulcer.But existing medical film comes with some shortcomings, as lacked flexibility, ventilative bad, act on single etc..Accordingly, it would be desirable to develop a kind of high-elastic ventilative and that there is antiphlogistic antibacterial effect medical film.
Summary of the invention
It is an object of the invention to provide a kind of medical film with antiphlogistic antibacterial effect.
To achieve these goals, the invention provides a kind of medical film with antiphlogistic antibacterial effect, the following component including in parts by weight: polyester fiber 30-50 part, gelatin 15-20 part, sodium alginate 5-12 part, cellulose 3-8 part, poly-sub-carboxyl carbon acid esters 6-9 part, ethyl acetate 3-7 part, Herba Pogostemonis powder 10-20 part, Radix Sangusorbae powder 11-14 part, glutamic acid 2-5 part, Laurel nitrogenKetone 3-6 part, metronidazole 3-8 part, zinc oxide 3-5 part, sodium carboxymethyl cellulose 5-10 part.
It also comprises sodium lauryl sulphate 2-8 part.
It also comprises procyanidin 10-15 part.
It also comprises nano zine oxide 5-8 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in container, after the most ultrasonic 1-6h, is then heated to 80-110 DEG C, stirs 1-3h, after extruded for mixed material machine spiro rod plasticizing, from die head die orifice extrusion molding;The material of above-mentioned extrusion molding is cooled down through inside and outside vane, more rotated traction, stretching, trimming, final rolling prepares the medical film with antiphlogistic antibacterial effect.
Beneficial effect: it is good that a kind of medical film with antiphlogistic antibacterial effect of the present invention has effect of antiphlogistic antibacterial, biocompatibility and histocompatibility, non-stimulated to tissue, good springiness, air permeable effect is good, little to the zest of skin, harmless to human non-toxic.
Detailed description of the invention
Embodiment 1
The medical film with antiphlogistic antibacterial effect of the present embodiment, the following component including in parts by weight: 30 parts of polyester fiber, 15 parts of gelatin, sodium alginate 5 parts, cellulose 3 parts, poly-sub-carboxyl carbon acid esters 6 parts, ethyl acetate 3 parts, 10 parts of Herba Pogostemonis powder, Radix Sangusorbae powder 11 parts, 2 parts of glutamic acid, Laurel nitrogenKetone 3 parts, metronidazole 3 parts, zinc oxide 3 parts, sodium carboxymethyl cellulose 5 parts.
Embodiment 2
The medical film with antiphlogistic antibacterial effect of the present embodiment, the following component including in parts by weight: 50 parts of polyester fiber, 20 parts of gelatin, sodium alginate 12 parts, cellulose 8 parts, poly-sub-carboxyl carbon acid esters 9 parts, ethyl acetate 7 parts, 20 parts of Herba Pogostemonis powder, Radix Sangusorbae powder 14 parts, 5 parts of glutamic acid, Laurel nitrogenKetone 6 parts, metronidazole 8 parts, zinc oxide 5 parts, sodium carboxymethyl cellulose 10 parts, sodium lauryl sulphate 8 parts.
Embodiment 3
The medical film with antiphlogistic antibacterial effect of the present embodiment, the following component including in parts by weight: 30 parts of polyester fiber, 15 parts of gelatin, sodium alginate 5 parts, cellulose 3 parts, poly-sub-carboxyl carbon acid esters 6 parts, ethyl acetate 3 parts, 10 parts of Herba Pogostemonis powder, Radix Sangusorbae powder 11 parts, 2 parts of glutamic acid, Laurel nitrogenKetone 3 parts, metronidazole 3 parts, zinc oxide 3 parts, sodium carboxymethyl cellulose 5 parts, sodium lauryl sulphate 2 parts, procyanidin 10 parts.
Embodiment 4
The medical film with antiphlogistic antibacterial effect of the present embodiment, the following component including in parts by weight: 50 parts of polyester fiber, 20 parts of gelatin, sodium alginate 12 parts, cellulose 8 parts, poly-sub-carboxyl carbon acid esters 9 parts, ethyl acetate 7 parts, 20 parts of Herba Pogostemonis powder, Radix Sangusorbae powder 14 parts, 5 parts of glutamic acid, Laurel nitrogenKetone 6 parts, metronidazole 8 parts, zinc oxide 5 parts, sodium carboxymethyl cellulose 10 parts, sodium lauryl sulphate 8 parts, procyanidin 15 parts, nano zine oxide 8 parts.
The above, it it is only presently preferred embodiments of the present invention, not the present invention is made any pro forma restriction, although the present invention is disclosed above with preferred embodiment, but it is not limited to the present invention, any those skilled in the art, in the range of without departing from technical solution of the present invention, when the technology contents of available the disclosure above makes a little change or is modified to the Equivalent embodiments of equivalent variations, in every case it is the content without departing from technical solution of the present invention, any simple modification above example made according to the technical spirit of the present invention, equivalent variations and modification, all still fall within the range of technical solution of the present invention.

Claims (4)

1. a medical film with antiphlogistic antibacterial effect, it is characterised in that include according to weight The following component of amount number meter: polyester fiber 30-50 part, gelatin 15-20 part, sodium alginate 5-12 part, cellulose 3-8 part, poly-sub-carboxyl carbon acid esters 6-9 part, ethyl acetate 3-7 part, Herba Pogostemonis powder 10-20 part, Radix Sangusorbae powder 11-14 part, glutamic acid 2-5 part, Laurel nitrogenKetone 3-6 Part, metronidazole 3-8 part, zinc oxide 3-5 part, sodium carboxymethyl cellulose 5-10 part.
The medical film with antiphlogistic antibacterial effect the most according to claim 1, it is special Levy and be: it also comprises sodium lauryl sulphate 2-8 part.
The medical film with antiphlogistic antibacterial effect the most according to claim 2, it is special Levy and be: it also comprises procyanidin 10-15 part.
The medical film with antiphlogistic antibacterial effect the most according to claim 3, it is special Levy and be: it also comprises nano zine oxide 5-8 part.
CN201610394258.3A 2016-06-06 2016-06-06 Medical membrane with anti-inflammation and antibacterial effects Withdrawn CN105963758A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610394258.3A CN105963758A (en) 2016-06-06 2016-06-06 Medical membrane with anti-inflammation and antibacterial effects

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CN201610394258.3A CN105963758A (en) 2016-06-06 2016-06-06 Medical membrane with anti-inflammation and antibacterial effects

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10135676A1 (en) * 2001-07-21 2003-02-06 Degussa Bioactives Deutschland Permeable film of cellulose, useful e.g. as wound dressing or skin replacement, includes chitosan or hyaluronic acid, allows gas exchange and prevents fluid loss
CN1422671A (en) * 2001-11-23 2003-06-11 吴天祥 Medical paste film
CN101804218A (en) * 2010-04-13 2010-08-18 王艳 Human-body absorbable trauma dressing containing Yunnan white drug powder or Yunnan white drug powder extractive
CN102327651A (en) * 2010-07-12 2012-01-25 北京迈迪顶峰医疗科技有限公司 Anti-adhesion membrane
CN104368035A (en) * 2013-08-13 2015-02-25 凌峰 Biological dressing for eliminating white spots and scars on human body
CN104877332A (en) * 2015-05-22 2015-09-02 苏州市贝克生物科技有限公司 Method for preparing medical film

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10135676A1 (en) * 2001-07-21 2003-02-06 Degussa Bioactives Deutschland Permeable film of cellulose, useful e.g. as wound dressing or skin replacement, includes chitosan or hyaluronic acid, allows gas exchange and prevents fluid loss
CN1422671A (en) * 2001-11-23 2003-06-11 吴天祥 Medical paste film
CN101804218A (en) * 2010-04-13 2010-08-18 王艳 Human-body absorbable trauma dressing containing Yunnan white drug powder or Yunnan white drug powder extractive
CN102327651A (en) * 2010-07-12 2012-01-25 北京迈迪顶峰医疗科技有限公司 Anti-adhesion membrane
CN104368035A (en) * 2013-08-13 2015-02-25 凌峰 Biological dressing for eliminating white spots and scars on human body
CN104877332A (en) * 2015-05-22 2015-09-02 苏州市贝克生物科技有限公司 Method for preparing medical film

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Title
苑振亭 等主编: "《临证中药500味手册(配彩图)》", 29 February 2016, 金盾出版社 *

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