CN1059340A - Extraction process of neomycin sulfate by use of static method - Google Patents
Extraction process of neomycin sulfate by use of static method Download PDFInfo
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- CN1059340A CN1059340A CN 91104766 CN91104766A CN1059340A CN 1059340 A CN1059340 A CN 1059340A CN 91104766 CN91104766 CN 91104766 CN 91104766 A CN91104766 A CN 91104766A CN 1059340 A CN1059340 A CN 1059340A
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- resin
- exchange resin
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- decolouring
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Abstract
The present invention relates to the technology that a kind of static adsorptive method extracts neomycinsulphate.It is to adopt the method that directly drops into the storng-acid cation exchange resin Static Adsorption in Xin Meisu fermentation diluent to adsorb Xin Meisu; The washing that is adsorbed with the saturated resin of Xin Meisu is to adopt hydrochloric acid and ammonium chloride mixed solution to wash, with the weak ammonia washing, again with ammoniacal liquor desorb and strongly basic anion exchange resin decolouring.Its technological operation is simple, and facility investment is few, the product yield height, and cost is low.
Description
The method that the present invention relates to a kind of spent ion exchange resin Static Adsorption is extracted the technology of neomycinsulphate, i.e. extraction process of neomycin sulfate by use of static method.
At present, the method for extracting neomycinsulphate is to adopt dynamic adsorption method, and its technology comprises that fermented liquid dilution, diluent carry out that the back suction of multiple-effect series connection absorption ebullated bed is attached, saturated resin washs, uses processes such as ammoniacal liquor desorb with ammoniacal liquor and urea mixed solution.In carrying out multiple-effect series connection ebullated bed back suction additive process, the technical requirements height, the technological operation complexity, and also facility investment is big, and utilization ratio is low, and saturated resin washs with ammoniacal liquor and urea mixed solution, and the big yield of product loss is low, the extraction cost height.
It is few to the purpose of this invention is to provide a kind of facility investment, and technological operation is simple, the product yield height, and the static adsorptive method that extraction cost is low extracts neomycinsulphate technology.
The object of the present invention is achieved like this:
With Xin Meisu fermented liquid dilute with water, drop into storng-acid cation exchange resin then, about whip attachment 5 hours, with vibratory screening apparatus resin is separated with waste liquid, to be adsorbed with in the saturated strong-acid ion exchange resin suction desorb post of Xin Meisu, press the mixed solution washing with hydrochloric acid and chlorination, wash with weak ammonia again, use the ammoniacal liquor desorb then, decolour with strongly basic anion exchange resin again, to free liquid is 66650 handkerchiefs in vacuum tightness, carry out thin film concentration under the condition of 40-50 ℃ of temperature, again concentrated solution is regulated pH value with chemical pure sulfuric acid and make the Xin Meisu salify to 5.5-6.5, it is refining to become saline solution to add 5% activated carbon decolorizing of solution weight, the spray-dried neomycinsulphate finished product that promptly gets of refined liquid, packing at last.
Static adsorptive method of the present invention extracts Xin Meisu technology, absorption to Xin Meisu fermentation diluent is to adopt Static Adsorption, its adsorption process only needs to finish in thinning tank, do not need the adsorption column and the attached ebullated bed of back suction that adopt in the dynamic adsorption method, make production unit simple like this, easy to operate, the wash-out of saturated resin washs with weak ammonia after adopting hydrochloric acid and ammonia chloride mixing, washing again, free with ammoniacal liquor at last, the yield of product improves with the yield of ammoniacal liquor and urea mixing, washing like this, and cost has also reduced.
The present invention is further described below in conjunction with accompanying drawing.
Fig. 1 is the extraction process of neomycin sulfate by use of static method schema.
According to process flow sheet shown in Figure 1, at first in thinning tank, the Xin Meisu fermented liquid is diluted with water to 2000 mcg/ml, add 0.1% NaHSO
3And then input storng-acid cation exchange resin absorption, its consumption is by 70,000 mcg/ml inputs, start and stir, Static Adsorption 5 hours, temperature are controlled at 28-32 ℃, to adsorb saturated resin with vibratory screening apparatus then separates with waste liquid, clean up, again with in the saturated Zeo-karb suction desorb post, with 0.15 mol HCl and 0.2 mol NH
4The Cl mixing, washing, use 0.1 mol ammonia scrubbing again, the consumption of hydrochloric acid and ammonia chloride mixed solution is 10 times of weight resin, free with the ammoniacal liquor of 1 mol the washing back, to free the liquid decolouring with strongly basic anion exchange resin, to free liquid again is 66650 handkerchiefs in vacuum tightness, thin film concentration under the 40-50 ℃ of condition, add chemical pure sulfuric acid in the concentrated solution again and adjust pH value to 5.5-6.5, make the Xin Meisu salify, the activated carbon decolorizing that adds solution weight 5% in becoming saline solution is refining, at last with the spray-dried neomycinsulphate finished product that promptly gets of refined liquid.
Claims (2)
1, a kind of extraction process of neomycin sulfate by use of static method, comprise fermented liquid dilution, diluent absorption, saturated resin wash-out and decolouring, free in liquid thin film concentration, the concentrated solution, become that the saline solution activated carbon decolorizing is made with extra care with salify, technological processs such as refined liquid spraying drying and neomycinsulphate finished product packing, it is characterized in that: diluent absorption is to adopt Static Adsorption, in adsorption process, drop into storng-acid cation exchange resin, stir vibration separation resin and waste liquid; The saturated resin wash-out adopts hydrochloric acid and ammonium chloride mixing, washing, uses the decolouring of ammoniacal liquor desorb and strongly basic anion exchange resin again with the weak ammonia washing with decolouring.
2, extraction process of neomycin sulfate by use of static method according to claim 1 is characterized in that the storng-acid cation exchange resin amount that drops in the Static Adsorption process preferentially selects for use every milliliter of diluent to throw storng-acid cation exchange resin 70,000 micrograms; The weight of used hydrochloric acid of saturated resin wash-out and ammonium chloride is 8 to 12 times of weight resin, and the concentration of hydrochloric acid is preferentially selected 0.15 mol for use, and the concentration of ammonium chloride is preferentially selected 0.2 mol for use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91104766 CN1029232C (en) | 1991-07-11 | 1991-07-11 | Extraction process of neomycin sulfate by use of static method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91104766 CN1029232C (en) | 1991-07-11 | 1991-07-11 | Extraction process of neomycin sulfate by use of static method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1059340A true CN1059340A (en) | 1992-03-11 |
| CN1029232C CN1029232C (en) | 1995-07-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 91104766 Expired - Fee Related CN1029232C (en) | 1991-07-11 | 1991-07-11 | Extraction process of neomycin sulfate by use of static method |
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| Country | Link |
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| CN (1) | CN1029232C (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101343295B (en) * | 2008-08-25 | 2010-12-08 | 石家庄华曙制药集团有限公司 | Method for extracting francisella native from bykomycin fermentation liquor |
| CN101446578B (en) * | 2008-12-24 | 2011-10-12 | 宜昌三峡制药有限公司 | Rapid measurement method of neomycin content in fermentation liquid and device therefor |
| CN102532214A (en) * | 2010-12-28 | 2012-07-04 | 三达膜科技（厦门）有限公司 | Method for decolorizing and purifying paromomycin |
| CN104558068A (en) * | 2014-12-19 | 2015-04-29 | 宜昌三峡制药有限公司 | Method for extracting high-quality neomycin and device adopted thereby |
| CN104610395A (en) * | 2015-01-19 | 2015-05-13 | 河北圣雪大成制药有限责任公司 | Method for extracting neomycin sulfate from neomycin sulfate fermentation broth |
| CN105418701A (en) * | 2015-12-24 | 2016-03-23 | 宜昌三峡制药有限公司 | Method for extracting neomycin from neomycin broth |
| CN106317138A (en) * | 2016-08-25 | 2017-01-11 | 宁夏泰益欣生物科技有限公司 | Extraction method of neomycin sulfate |
| CN107915763A (en) * | 2016-10-09 | 2018-04-17 | 津药新瑞制药股份有限公司 | A kind of method of neomycin fermented waste fluid slag-liquid separation and recycling residual neomycin |
| CN111333687A (en) * | 2020-03-11 | 2020-06-26 | 吕志洪 | Method for extracting franocidine sulfate from neomycin sulfate |
| CN114317644A (en) * | 2021-12-31 | 2022-04-12 | 宜昌三峡制药有限公司 | Method and fermentation device for improving fermentation yield in neomycin sulfate production |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101021536B (en) * | 2007-03-12 | 2011-06-22 | 北京望尔康泰生物技术有限公司 | Enzyme-linked immunological kit for detecting neomycin drug and method |
-
1991
- 1991-07-11 CN CN 91104766 patent/CN1029232C/en not_active Expired - Fee Related
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101343295B (en) * | 2008-08-25 | 2010-12-08 | 石家庄华曙制药集团有限公司 | Method for extracting francisella native from bykomycin fermentation liquor |
| CN101446578B (en) * | 2008-12-24 | 2011-10-12 | 宜昌三峡制药有限公司 | Rapid measurement method of neomycin content in fermentation liquid and device therefor |
| CN102532214A (en) * | 2010-12-28 | 2012-07-04 | 三达膜科技（厦门）有限公司 | Method for decolorizing and purifying paromomycin |
| CN102532214B (en) * | 2010-12-28 | 2014-12-10 | 三达膜科技（厦门）有限公司 | Method for decolorizing and purifying paromomycin |
| CN104558068B (en) * | 2014-12-19 | 2017-06-06 | 宜昌三峡制药有限公司 | A kind of method and equipment therefor for extracting high-quality neomycin |
| CN104558068A (en) * | 2014-12-19 | 2015-04-29 | 宜昌三峡制药有限公司 | Method for extracting high-quality neomycin and device adopted thereby |
| CN104610395A (en) * | 2015-01-19 | 2015-05-13 | 河北圣雪大成制药有限责任公司 | Method for extracting neomycin sulfate from neomycin sulfate fermentation broth |
| CN104610395B (en) * | 2015-01-19 | 2018-07-13 | 河北圣雪大成制药有限责任公司 | A method of extracting neomycinsulphate from neomycinsulphate zymotic fluid |
| CN105418701A (en) * | 2015-12-24 | 2016-03-23 | 宜昌三峡制药有限公司 | Method for extracting neomycin from neomycin broth |
| CN105418701B (en) * | 2015-12-24 | 2018-04-10 | 宜昌三峡制药有限公司 | A kind of method that neomycin is extracted in the zymotic fluid from neomycin |
| CN106317138A (en) * | 2016-08-25 | 2017-01-11 | 宁夏泰益欣生物科技有限公司 | Extraction method of neomycin sulfate |
| CN107915763A (en) * | 2016-10-09 | 2018-04-17 | 津药新瑞制药股份有限公司 | A kind of method of neomycin fermented waste fluid slag-liquid separation and recycling residual neomycin |
| CN111333687A (en) * | 2020-03-11 | 2020-06-26 | 吕志洪 | Method for extracting franocidine sulfate from neomycin sulfate |
| CN114317644A (en) * | 2021-12-31 | 2022-04-12 | 宜昌三峡制药有限公司 | Method and fermentation device for improving fermentation yield in neomycin sulfate production |
| CN114317644B (en) * | 2021-12-31 | 2023-08-08 | 宜昌三峡制药有限公司 | Method for improving fermentation yield of neomycin sulfate production and fermentation device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1029232C (en) | 1995-07-05 |
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Applicant after: Guanghua Fermentation Chemical Plant, Yichang City Applicant before: Guanghua Fermentation Chemical Plant, Yichang City |
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