CN105418701A - Method for extracting neomycin from neomycin broth - Google Patents
Method for extracting neomycin from neomycin broth Download PDFInfo
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- CN105418701A CN105418701A CN201510999448.3A CN201510999448A CN105418701A CN 105418701 A CN105418701 A CN 105418701A CN 201510999448 A CN201510999448 A CN 201510999448A CN 105418701 A CN105418701 A CN 105418701A
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- neomycin sulphate
- liu suanyan
- suanyan neomycin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
- C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
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Abstract
The invention relates to a method for extracting neomycin from a neomycin broth. The method comprises the following steps: 1) heating the neomycin broth to temperature of 65-75 DEG C; 2) placing a diatomite filter aid with mass accounting for 1-2% of that of the neomycin broth in the heated neomycin broth; 3) filtering the neomycin broth prepared in the step 2) with a filter to obtain a clear liquid containing neomycin; 4) loading the clear liquid containing neomycin to directly carry out column adsorption; and 5) desorbing the clear liquid and concentrating the clear liquid to prepare the neomycin finished product. The method for extracting neomycin from the neomycin broth can solve the environmental protection problem in neomycin production, energy saving for the novel extraction technology for neomycin sulfate can be realized, and cleaning production can be realized.
Description
Technical field
The present invention relates to Liu Suanyan NEOMYCIN SULPHATE production field, especially a kind of method extracting Liu Suanyan NEOMYCIN SULPHATE from Liu Suanyan NEOMYCIN SULPHATE fermented liquid.
Background technology
At present, the extracting method of Liu Suanyan NEOMYCIN SULPHATE product continues to use traditional technology always, namely in Liu Suanyan NEOMYCIN SULPHATE fermented liquid, drops into polymeric adsorbent, after resin absorption Liu Suanyan NEOMYCIN SULPHATE upon adsorption is saturated, by resin and Liu Suanyan NEOMYCIN SULPHATE separation of fermentative broth, then the method for desorb is adopted to be got off from desorb resin by Liu Suanyan NEOMYCIN SULPHATE.By current factory Liu Suanyan NEOMYCIN SULPHATE industrial scale, at least produce 300 tons of Liu Suanyan NEOMYCIN SULPHATE fermented liquids every day, these Liu Suanyan NEOMYCIN SULPHATE fermented liquids have been after in input, polymeric adsorbent adsorbed, and need carry out being separated of resin and Liu Suanyan NEOMYCIN SULPHATE fermented liquid.Extract employing 80 object vibratory screening apparatus to sieve, simultaneously, rinse with a large amount of water in the process of sieving, water consumption remains on the ratio of 1:1 substantially, namely becomes waste water after the water of flushing mixes with the water of Liu Suanyan NEOMYCIN SULPHATE fermented liquid, simultaneously, because of adsorption time long (more than 8 hours), add that temperature is higher, the Liu Suanyan NEOMYCIN SULPHATE fermented liquid of being rich in nutrition composition can be contaminated, produce niff, cause the complaint of surrounding resident.
Having foregoing known, there is following defect in Conventional processing methods:
One, water consumption is high;
Two, resin cracky;
Three, a large amount of waste water is produced;
Four, niff is produced.
Along with the enforcement of the new environmental law of country, the environmental protection pressure of enterprise is increasing, does not solve a large amount of waste water and niff, and enterprise will be faced with crisis of survival.Therefore be badly in need of improving the method that in the production of Liu Suanyan NEOMYCIN SULPHATE Liu Suanyan NEOMYCIN SULPHATE fermented liquid, extraction process controls, thus reach environmental protection, energy-conservation production requirement.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of method extracting Liu Suanyan NEOMYCIN SULPHATE from Liu Suanyan NEOMYCIN SULPHATE fermented liquid, can solve the environmental issue in Liu Suanyan NEOMYCIN SULPHATE production, make the novel technology for extracting of neomycinsulphate more energy-conservation, realize cleaner production.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of method extracting Liu Suanyan NEOMYCIN SULPHATE from Liu Suanyan NEOMYCIN SULPHATE fermented liquid, and the method comprises the following steps:
1) heat: Liu Suanyan NEOMYCIN SULPHATE fermented liquid is heated to 65-75 DEG C;
2) in the Liu Suanyan NEOMYCIN SULPHATE fermented liquid after heating, drop into the super-cell of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality 1 – 2 ﹪, and stir;
Flocculating aids is super-cell;
3) by step 2) obtained Liu Suanyan NEOMYCIN SULPHATE fermented liquid filtered by filter, by the solid phase of Liu Suanyan NEOMYCIN SULPHATE fermented liquid and liquid phase separation, obtains the clear liquid containing Liu Suanyan NEOMYCIN SULPHATE;
4) by step 3) the obtained clear liquid containing Liu Suanyan NEOMYCIN SULPHATE directly carries out upper prop absorption;
5) carry out desorb again, concentrate, turn salt, refine, dust, be i.e. obtained Liu Suanyan NEOMYCIN SULPHATE finished product.
Step 4) in " upper prop absorption " refer to by clear liquid by Cemented filling pass into from friendship post, the mode passed into is from down to up, clear liquid is when flowing through from friendship post, in its liquid, contained Liu Suanyan NEOMYCIN SULPHATE is by resin absorption in post, when the Liu Suanyan NEOMYCIN SULPHATE adsorbed reaches capacity, just become saturated resin, one abstraction process can be entered down.From handing over post to be exactly by the container of columniform metal tin inner lining glass fiber reinforced plastic, in-built empty resin composition.
Step 1) in, Liu Suanyan NEOMYCIN SULPHATE fermented liquid is heated to 70 DEG C.
Step 2) in, also add rice chaff powder forming agent,
Rice chaff opaque amount is 2 – 3 ﹪ of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality.
Step 3) in, filter is flame filter press.
The invention process of the inventive method is as follows:
Make a general survey of in whole technical process, filtration is a wherein the most key step, if can be successful, and being just readily solved of other.Enterprise has successively carried out the research of multiple project such as ceramic membrane filter, whizzer filtration, data presentation, and these two kinds of filter methods are all undesirable to Liu Suanyan NEOMYCIN SULPHATE Liu Suanyan NEOMYCIN SULPHATE fermented liquid, comparing, have finally chosen Plate Filtration through repeatedly studying.
When not adding any flocculating aids, the filtration velocity of Liu Suanyan NEOMYCIN SULPHATE fermented liquid is comparatively slow, can not meet Production requirement, after suitable flocculating aids and economical and practical filtration condition are applied to Liu Suanyan NEOMYCIN SULPHATE extraction process, obtain ideal effect.
1, the selection of filtration adjuvant
Viscosity for Liu Suanyan NEOMYCIN SULPHATE fermented liquid is high, solid content is high, the feature that nutrient composition content is high, we pick various flocculation agent, sinking agent, flocculating aids carry out filtration simultaneous test, concrete grammar is: get Liu Suanyan NEOMYCIN SULPHATE fermented liquid 1.5 tons, amount adds various flocculation agent routinely, sinking agent, flocculating aids carry out simultaneous test, observe filtration velocity and the quality crossing cleaner liquid, determine best flocculating aids.
Experimental result is as follows:
As can be seen from the above results, under identical condition, the filtrate quality obtained all meets the requirements, but with the addition of diatomite criticizes filtering velocity as the test of flocculating aids and obviously want fast a lot.
Flocculation agent 1# is Xylo-Mucine;
Flocculation agent 2# is polyacrylamide.
2, based on super-cell, grope both economical, the processing condition be suitable for again
Research through laboratory shows, after carrying out heat treatment to fermented liquid, fermented liquid viscosity obviously declines, and has larger help to filtration.
Above-mentioned serial experiment result proves, at 70 DEG C, when adding the super-cell of 1%-2%, filter Liu Suanyan NEOMYCIN SULPHATE fermented liquid, can obtain filtering velocity faster, filter cake is shaping, quick detachable.Use part rice chaff powder to replace part diatomite, taken into account economy, also achieved good experiment effect.Average yield is all stable reaches more than 90%.
A kind of method extracting Liu Suanyan NEOMYCIN SULPHATE from Liu Suanyan NEOMYCIN SULPHATE fermented liquid provided by the invention, beneficial effect is as follows:
1, utilize Liu Suanyan NEOMYCIN SULPHATE very easily water-soluble, Liu Suanyan NEOMYCIN SULPHATE in Liu Suanyan NEOMYCIN SULPHATE fermented liquid is substantially all present in liquid phase, as long as the solid phase of fermentation and liquid phase are separated, the principle of the clear liquid containing Liu Suanyan NEOMYCIN SULPHATE can be obtained, realize by flocculating aids and filter the removal that in Liu Suanyan NEOMYCIN SULPHATE fermented liquid, major part is organic simply, to solve the environmental issue in Liu Suanyan NEOMYCIN SULPHATE production, make the novel technology for extracting of neomycinsulphate more energy-conservation, realize cleaner production, method steps is simple.
2, to solve in existing extraction process that water consumption is high, resin cracky and produce the problems such as a large amount of waste water and niff, reach and promote that automation degree of equipment improves, saving great lot of water resources, minimizing discharge of wastewater, achieve cleaner production, simultaneously, the bacterium slag filtered out significantly reduces the COD in waste water, alleviates wastewater treatment difficulty.
3, have found suitable flocculating aids-diatomite, and determine suitable dosage ratio; Have found forming agent-rice chaff powder that filter residue is shaped, and determine suitable dosage ratio; And have selected fermented liquid heating mode, and determine suitable temperature value, accelerate filtration velocity.Make flame filter press be applied in the extraction process of Liu Suanyan NEOMYCIN SULPHATE, achieve cleaner production.
4, the economic benefit obtained is as follows:
After in June, 2015, company formally implemented Plate Filtration technique, dynamic adsorption is able to smooth enforcement, 6-August, reduces positive resin loss 20 tons, amounts to Renminbi 100,000 yuan; Reduce product loss 3,000 1,000,000,000, amount to Renminbi 250,000 yuan, exclude the diatomaceous input about 100,000 yuan that Plate Filtration increases, quarterly can have a net increase of profit 250,000 yuan, major part organic matter in fermented liquid is removed, solve the pressure of environmental protection station 70%, remaining a part of waste water environmental protection station just can easily solve, annual minimizing Environmental Inputs more than 3,000,000 yuan.Be equivalent to can be enterprise every year and increase profit about 4,000,000 yuan.
5, other comprehensive benefits obtained are as follows:
After this project implementation application, the major part organic matter in fermented liquid is removed, and solves the pressure of environmental protection station 70%, and remaining a part of waste water environmental protection station just can easily solve, and solves environmental issue, also brings unlimited development space to enterprise.For obstacle has been cleared away in the smooth enforcement of novel process.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described:
Fig. 1 is the comparison diagram before Liu Suanyan NEOMYCIN SULPHATE fermented liquid adopts the inventive method to filter and after filtering.
Embodiment
Embodiment one
From Liu Suanyan NEOMYCIN SULPHATE fermented liquid, extract a method for Liu Suanyan NEOMYCIN SULPHATE, the method comprises the following steps:
1) heat: Liu Suanyan NEOMYCIN SULPHATE fermented liquid is heated to 65 DEG C;
2) in the Liu Suanyan NEOMYCIN SULPHATE fermented liquid after heating, drop into the super-cell of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality 2 ﹪, and stir.
Flocculating aids is super-cell;
3) by step 2) obtained Liu Suanyan NEOMYCIN SULPHATE fermented liquid filtered by filter, by the solid phase of Liu Suanyan NEOMYCIN SULPHATE fermented liquid and liquid phase separation, obtains the clear liquid containing Liu Suanyan NEOMYCIN SULPHATE;
4) by step 3) the obtained clear liquid containing Liu Suanyan NEOMYCIN SULPHATE directly carries out upper prop absorption;
5) carry out desorb again, concentrate, turn salt, refine, dust, be i.e. obtained Liu Suanyan NEOMYCIN SULPHATE finished product.
Step 3) in, filter is flame filter press.
Embodiment two
From Liu Suanyan NEOMYCIN SULPHATE fermented liquid, extract a method for Liu Suanyan NEOMYCIN SULPHATE, the method comprises the following steps:
1) heat: Liu Suanyan NEOMYCIN SULPHATE fermented liquid is heated to 70 DEG C;
2) in the Liu Suanyan NEOMYCIN SULPHATE fermented liquid after heating, drop into the super-cell of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality 1 ﹪, and stir;
Flocculating aids is super-cell;
3) by step 2) obtained Liu Suanyan NEOMYCIN SULPHATE fermented liquid filtered by filter, by the solid phase of Liu Suanyan NEOMYCIN SULPHATE fermented liquid and liquid phase separation, obtains the clear liquid containing Liu Suanyan NEOMYCIN SULPHATE;
4) by step 3) the obtained clear liquid containing Liu Suanyan NEOMYCIN SULPHATE directly carries out upper prop absorption;
5) carry out desorb again, concentrate, turn salt, refine, dust, be i.e. obtained Liu Suanyan NEOMYCIN SULPHATE finished product.
Step 3) in, filter is flame filter press.
Embodiment three
From Liu Suanyan NEOMYCIN SULPHATE fermented liquid, extract a method for Liu Suanyan NEOMYCIN SULPHATE, the method comprises the following steps:
1) heat: Liu Suanyan NEOMYCIN SULPHATE fermented liquid is heated to 75 DEG C;
2) in the Liu Suanyan NEOMYCIN SULPHATE fermented liquid after heating, drop into the super-cell of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality 1 ﹪, and stir;
Flocculating aids is super-cell;
3) by step 2) obtained Liu Suanyan NEOMYCIN SULPHATE fermented liquid filtered by filter, by the solid phase of Liu Suanyan NEOMYCIN SULPHATE fermented liquid and liquid phase separation, obtains the clear liquid containing Liu Suanyan NEOMYCIN SULPHATE;
4) by step 3) the obtained clear liquid containing Liu Suanyan NEOMYCIN SULPHATE directly carries out upper prop absorption;
5) carry out desorb again, concentrate, turn salt, refine, dust, be i.e. obtained Liu Suanyan NEOMYCIN SULPHATE finished product.
Step 3) in, filter is flame filter press.
Embodiment four
From Liu Suanyan NEOMYCIN SULPHATE fermented liquid, extract a method for Liu Suanyan NEOMYCIN SULPHATE, the method comprises the following steps:
1) heat: Liu Suanyan NEOMYCIN SULPHATE fermented liquid is heated to 65 DEG C;
2) in the Liu Suanyan NEOMYCIN SULPHATE fermented liquid after heating, drop into the super-cell of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality 2 ﹪, and stir.
Flocculating aids is super-cell;
3) by step 2) obtained Liu Suanyan NEOMYCIN SULPHATE fermented liquid filtered by filter, by the solid phase of Liu Suanyan NEOMYCIN SULPHATE fermented liquid and liquid phase separation, obtains the clear liquid containing Liu Suanyan NEOMYCIN SULPHATE;
4) by step 3) the obtained clear liquid containing Liu Suanyan NEOMYCIN SULPHATE directly carries out upper prop absorption;
5) carry out desorb, concentrate, turn salt, refine, dust, be i.e. obtained Liu Suanyan NEOMYCIN SULPHATE finished product.
Step 2) in, also add rice chaff powder forming agent,
Rice chaff opaque amount is 2 ﹪ of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality.
Step 3) in, filter is flame filter press.
Embodiment five
From Liu Suanyan NEOMYCIN SULPHATE fermented liquid, extract a method for Liu Suanyan NEOMYCIN SULPHATE, the method comprises the following steps:
1) heat: Liu Suanyan NEOMYCIN SULPHATE fermented liquid is heated to 70 DEG C;
2) in the Liu Suanyan NEOMYCIN SULPHATE fermented liquid after heating, drop into the super-cell of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality 1 ﹪, and stir.
Flocculating aids is super-cell;
3) by step 2) obtained Liu Suanyan NEOMYCIN SULPHATE fermented liquid filtered by filter, by the solid phase of Liu Suanyan NEOMYCIN SULPHATE fermented liquid and liquid phase separation, obtains the clear liquid containing Liu Suanyan NEOMYCIN SULPHATE;
4) by step 3) the obtained clear liquid containing Liu Suanyan NEOMYCIN SULPHATE directly carries out upper prop absorption;
5) carry out desorb, concentrate, turn salt, refine, dust, be i.e. obtained Liu Suanyan NEOMYCIN SULPHATE finished product.
Step 2) in, also add rice chaff powder forming agent,
Rice chaff opaque amount is 3 ﹪ of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality.
Step 3) in, filter is flame filter press.
Embodiment six
From Liu Suanyan NEOMYCIN SULPHATE fermented liquid, extract a method for Liu Suanyan NEOMYCIN SULPHATE, the method comprises the following steps:
1) heat: Liu Suanyan NEOMYCIN SULPHATE fermented liquid is heated to 75 DEG C;
2) in the Liu Suanyan NEOMYCIN SULPHATE fermented liquid after heating, drop into the super-cell of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality 2 ﹪, and stir.
Flocculating aids is super-cell;
3) by step 2) obtained Liu Suanyan NEOMYCIN SULPHATE fermented liquid filtered by filter, by the solid phase of Liu Suanyan NEOMYCIN SULPHATE fermented liquid and liquid phase separation, obtains the clear liquid containing Liu Suanyan NEOMYCIN SULPHATE;
4) by step 3) the obtained clear liquid containing Liu Suanyan NEOMYCIN SULPHATE directly carries out upper prop absorption;
5) carry out desorb, concentrate, turn salt, refine, dust, be i.e. obtained Liu Suanyan NEOMYCIN SULPHATE finished product.
Step 2) in, also add rice chaff powder forming agent,
Rice chaff opaque amount is 2 ﹪ of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality.
Step 3) in, filter is flame filter press.
Contrast photo before Liu Suanyan NEOMYCIN SULPHATE filtering fermentation liquor and after filtering as shown in Figure 1, can know that the Liu Suanyan NEOMYCIN SULPHATE fermented liquid before finding out filtration becomes muddy state, and obviously clarification after filtering.
In the various embodiments described above, step 4) in, " upper prop absorption " is referred to and is passed into from friendship post by Cemented filling by clear liquid, and the mode passed into is from down to up, and clear liquid is when flowing through from friendship post, in its liquid, contained Liu Suanyan NEOMYCIN SULPHATE is by resin absorption in post, when the Liu Suanyan NEOMYCIN SULPHATE adsorbed reaches capacity, just become saturated resin, one abstraction process can be entered down, from handing over post to be exactly by the container of columniform metal tin inner lining glass fiber reinforced plastic, in-built empty resin composition.
Step 5) in, concentrate, turn salt, refine, dust for existing technique,
Desorb is pointed to saturated resin and is passed into certain density desorb ammonia solution, the Liu Suanyan NEOMYCIN SULPHATE desorb on saturated resin is got off;
Contained by the concentrated stripping liquid referring to desorb to be got off, unnecessary moisture and ammonia are evaporated away by thin-film evaporator, and the concentration making it Liu Suanyan NEOMYCIN SULPHATE reaches processing requirement;
Turning salt is add a certain amount of sulfuric acid in the Liu Suanyan NEOMYCIN SULPHATE concentrated solution of sensing pH meta-alkali, makes it to form pH in neutral neomycinsulphate;
Refining is point in the neomycinsulphate concentrated solution after turning salt to add gac, removes the impurity such as the pigment in concentrated solution, makes it by Plate Filtration the refined liquid that transmittance reaches specification of quality;
Dust and refer to that removal moisture forms the former powder of Liu Suanyan NEOMYCIN SULPHATE of powdery instantaneously by refined liquid obtained for decolouring by spray tower high-temperature injection.
Claims (4)
1. from Liu Suanyan NEOMYCIN SULPHATE fermented liquid, extract a method for Liu Suanyan NEOMYCIN SULPHATE, it is characterized in that the method comprises the following steps:
1) heat: Liu Suanyan NEOMYCIN SULPHATE fermented liquid is heated to 65-75 DEG C;
2) in the Liu Suanyan NEOMYCIN SULPHATE fermented liquid after heating, drop into the super-cell of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality 1 – 2 ﹪, and stir;
Flocculating aids is super-cell;
3) by step 2) obtained Liu Suanyan NEOMYCIN SULPHATE fermented liquid filtered by filter, by the solid phase of Liu Suanyan NEOMYCIN SULPHATE fermented liquid and liquid phase separation, obtains the clear liquid containing Liu Suanyan NEOMYCIN SULPHATE;
4) clear liquid containing Liu Suanyan NEOMYCIN SULPHATE step 3) obtained directly carries out upper prop absorption;
5) carry out desorb again, concentrate, turn salt, refine, dust, be i.e. obtained Liu Suanyan NEOMYCIN SULPHATE finished product.
2. a kind of method extracting Liu Suanyan NEOMYCIN SULPHATE from Liu Suanyan NEOMYCIN SULPHATE fermented liquid according to claim 1, is characterized in that: in step 1), heats Liu Suanyan NEOMYCIN SULPHATE fermented liquid to 70 DEG C.
3. a kind of method extracting Liu Suanyan NEOMYCIN SULPHATE from Liu Suanyan NEOMYCIN SULPHATE fermented liquid according to claim 1, is characterized in that: step 2) in, also add rice chaff powder forming agent,
Rice chaff opaque amount is 2 – 3 ﹪ of Liu Suanyan NEOMYCIN SULPHATE fermented liquid quality.
4. a kind of method extracting Liu Suanyan NEOMYCIN SULPHATE from Liu Suanyan NEOMYCIN SULPHATE fermented liquid according to claim 1, is characterized in that: in step 3), and filter is flame filter press.
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Cited By (6)
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| CN106317138A (en) * | 2016-08-25 | 2017-01-11 | 宁夏泰益欣生物科技有限公司 | Extraction method of neomycin sulfate |
| CN107915763A (en) * | 2016-10-09 | 2018-04-17 | 津药新瑞制药股份有限公司 | A kind of method of neomycin fermented waste fluid slag-liquid separation and recycling residual neomycin |
| CN108203453A (en) * | 2016-12-19 | 2018-06-26 | 宜昌三峡制药有限公司 | The method of automatic flame filter press large-scale production neomycin |
| CN109399835A (en) * | 2018-12-24 | 2019-03-01 | 宜昌三峡制药有限公司 | A kind of method that neomycinsulphate fermented waste fluid is separated by solid-liquid separation |
| CN110872333A (en) * | 2019-11-25 | 2020-03-10 | 宜昌三峡制药有限公司 | Process control method for neomycin preparation process |
| CN114011157A (en) * | 2021-11-08 | 2022-02-08 | 江苏力凡胶囊有限公司 | Additive-free filtering method for high-viscosity fermentation liquor |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106317138A (en) * | 2016-08-25 | 2017-01-11 | 宁夏泰益欣生物科技有限公司 | Extraction method of neomycin sulfate |
| CN107915763A (en) * | 2016-10-09 | 2018-04-17 | 津药新瑞制药股份有限公司 | A kind of method of neomycin fermented waste fluid slag-liquid separation and recycling residual neomycin |
| CN108203453A (en) * | 2016-12-19 | 2018-06-26 | 宜昌三峡制药有限公司 | The method of automatic flame filter press large-scale production neomycin |
| CN109399835A (en) * | 2018-12-24 | 2019-03-01 | 宜昌三峡制药有限公司 | A kind of method that neomycinsulphate fermented waste fluid is separated by solid-liquid separation |
| CN109399835B (en) * | 2018-12-24 | 2020-10-27 | 宜昌三峡制药有限公司 | Solid-liquid separation method for neomycin sulfate fermentation waste liquid |
| CN110872333A (en) * | 2019-11-25 | 2020-03-10 | 宜昌三峡制药有限公司 | Process control method for neomycin preparation process |
| CN114011157A (en) * | 2021-11-08 | 2022-02-08 | 江苏力凡胶囊有限公司 | Additive-free filtering method for high-viscosity fermentation liquor |
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