CN105920653B - Hydrogel scar removing patch and preparation method thereof - Google Patents
Hydrogel scar removing patch and preparation method thereof Download PDFInfo
- Publication number
- CN105920653B CN105920653B CN201610350314.3A CN201610350314A CN105920653B CN 105920653 B CN105920653 B CN 105920653B CN 201610350314 A CN201610350314 A CN 201610350314A CN 105920653 B CN105920653 B CN 105920653B
- Authority
- CN
- China
- Prior art keywords
- parts
- silicone gel
- weight
- stirring
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
A hydrogel scar removing patch and its preparation method are provided. A hydrogel scar-removing patch comprises the following components: the aloe hydrogel fixing layer is connected with the silicone gel film, and the polypropylene film stripping layer is arranged on the silicone gel film. The invention is used for treating bruise, scald, scratch, incised wound and the like.
Description
Technical Field
The invention relates to a hydrogel scar-removing patch and a preparation method thereof.
Background
The skin bruise, scald, scratch and cut are difficult to avoid in daily life, the wound can generate scars after healing, the longer the wound is healed, the more obvious the scars are, and the skin bruise, scald, scratch and cut of people is not beautiful.
For daily wound care, the cotton wool, gauze or bandage is mainly used, and the three types are formed on the basis of the dry healing theory of the wound. With further development of scientific research, the defects of the dry healing theory are gradually shown, such as easy dehydration of the wound, scabbing of the wound, long healing time and the like.
Disclosure of Invention
The invention aims to provide a hydrogel scar-removing patch capable of promoting wound healing and inhibiting scar formation and hyperplasia and a preparation method thereof.
The above purpose is realized by the following technical scheme:
a hydrogel scar-removing patch comprises the following components: the aloe hydrogel fixing layer is connected with the silicone gel film, and the polypropylene film stripping layer is arranged on the silicone gel film.
The hydrogel scar-removing patch is characterized in that the composite aloe hydrogel fixing layer comprises, by mass, 1-2 parts of aloe extract, 10-20 parts of neutralized sodium polyacrylate, 0.1 part of dihydroxyaluminum glycinate, 0.3 part of disodium ethylene diamine tetraacetate, 0.4 part of sodium tartrate, 90 parts of purified water and 5-8 parts of glycerol.
The hydrogel scar-removing patch is characterized in that the composite aloe hydrogel fixing layer comprises 1 mass part of aloe extract, 10 mass parts of neutralized sodium polyacrylate, 0.1 mass part of dihydroxyaluminum glycinate, 0.3 mass part of disodium ethylene diamine tetraacetate, 0.4 mass part of sodium tartrate, 90 mass parts of purified water and 5 mass parts of glycerol.
The hydrogel scar-removing patch is characterized in that the composite aloe hydrogel fixing layer comprises 2 parts by weight of aloe extract, 20 parts by weight of neutralized sodium polyacrylate, 0.1 part by weight of dihydroxyaluminum, 0.3 part by weight of disodium ethylenediaminetetraacetate, 0.4 part by weight of sodium tartrate, 90 parts by weight of purified water and 8 parts by weight of glycerol.
The hydrogel scar-removing patch is characterized in that the composite aloe hydrogel fixing layer comprises 1.5 parts by weight of aloe extract, 15 parts by weight of neutralized sodium polyacrylate, 0.1 part by weight of aluminum glycoxide, 0.3 part by weight of disodium edetate, 0.4 part by weight of sodium tartrate, 90 parts by weight of purified water and 6 parts by weight of glycerol.
The aloe extract is prepared by freeze drying aloe at low temperature for 8 hr, taking out, soaking in alcohol water solution at low temperature, and extracting.
A preparation method of a hydrogel scar removing paste comprises the steps of taking out medical silicone gel A and medical silicone gel B according to the proportion of 1:1.5-1:2, slowly pouring the silicone gel B into the silicone gel A, stirring at the speed of 200-400 r/min, and controlling the temperature at 28-35 ℃; the vacuum degree is-0.1 MPa, the stirring time is 30-50 minutes, and the stirring is finished; secondly, standing, pouring into a mould, and vulcanizing by an infrared dryer at the vulcanization temperature of 60-70 ℃ for 2-5 minutes; thirdly, dissolving 10-20 parts by mass of medical grade neutralization sodium polyacrylate in 5-8 parts by mass of glycerol, stirring for 2-3 minutes at the rotating speed of 600-; fourthly, 90 parts by mass of purified water is used for dissolving 0.4 to 0.5 part by mass of sodium tartrate and 1 to 2 parts by mass of aloe extract, then the mixture is poured into the glycerol suspension, the vacuum is controlled to be between 0.08 and 0.1MPa, the stirring speed is 1200 and 1400 revolutions per minute, and the temperature is set to be between 30 and 35 ℃. Stirring for 8-10 min, pouring into a mold for curing, placing in a curing chamber for curing, and taking out after curing at the temperature of 32-45 ℃ and the humidity of 40-70% for 600-1200 min; and fifthly, arranging the samples obtained in the steps 1, 2, 3 and 4 according to the sequence of a back lining layer, a composite aloe hydraulic fixing layer and a silicone gel film layer from bottom to top, and then covering a polypropylene film stripping layer to obtain the final product.
Has the advantages that:
1. the invention can accelerate the wound healing, obviously reduce the scars and beautify the skin.
2. The compound aloe hydrogel adopted by the invention can not only propagate bacteria and prevent infection after trauma, but also has strong vitamin D effect, can improve local blood circulation, and the effective components can penetrate into skin and be absorbed by tissues more easily.
3. The silicone gel film adopted by the invention has physical polysiloxane with high permeability and high air permeability, can promote the metabolism of skin epithelial tissue cells to achieve the purposes of inhibiting the growth of proliferative scars, changing the structure of scar tissues, promoting the skin keratinization of wound healing, and improving the structure of newly-healed epithelial tissues, thereby eliminating the proliferative scars after the life of the wound and the genetic damage of joint function, preventing scar contracture and proliferation, and particularly obviously inhibiting the recent proliferative scars.
4. The invention combines silicone gel and composite aloe hydrogel, and the aloe hydrogel is absorbed by skin after penetrating into the silicone gel, thereby inhibiting scar hyperplasia and scar formation.
5. The silicone gel membrane is used as a silicone gel membrane which is in contact with the skin, so that the biocompatibility is high, the safety and the stability are high, the silicone gel A and the silicone gel B are mixed according to the proportion of 1:1.5-1:2, the viscosity is high, the silicone gel A and the silicone gel B are not easy to fall off, the contact time with the skin is prolonged, and the scar hyperplasia inhibiting effect of the silicone gel membrane is improved.
6. The invention combines the silicone gel and the compound aloe hydrogel, can be repeatedly torn for use, and does not influence the effect of inhibiting scar hyperplasia after repeated use.
7. The aloe hydrogel composite layer and the silicone gel are matched to be beneficial to retaining water, enhancing the skin humidity, alleviating the growth of scars and inhibiting the generation of scars.
Description of the drawings:
fig. 1 is a schematic structural diagram of the product.
The specific implementation mode is as follows:
example 1:
a hydrogel scar-removing patch comprises the following components: the aloe hydrogel fixing layer is connected with the silicone gel film, and the polypropylene film stripping layer is arranged on the silicone gel film. The aloe hydrogel fixing layer is provided with a backing layer below.
The aloe hydrogel fixing layer comprises a backing layer 1, a composite aloe hydrogel fixing layer 2, a silicone gel film 3 and a polypropylene film stripping layer 4.
Example 2:
the hydrogel scar-removing patch in embodiment 1 is prepared from, by mass, 1-2 parts of an aloe extract, 10-20 parts of neutralized sodium polyacrylate, 0.1 part of dihydroxyaluminum glycinate, 0.3 part of disodium edetate, 0.4 part of sodium tartrate, 90 parts of purified water and 5-8 parts of glycerol.
Example 3:
the hydrogel scar-removing patch in embodiment 2 is prepared by mixing aloe extract 1, neutralized sodium polyacrylate 10, aluminum glycoxide 0.1, disodium edetate 0.3, sodium tartrate 0.4, purified water 90, and glycerin 5 in parts by weight of a composite aloe hydrogel fixing layer.
Example 4:
the hydrogel scar-removing patch in embodiment 2 is prepared by mixing aloe extract 2, neutralized sodium polyacrylate 20, aluminum glycoxide 0.1, disodium edetate 0.3, sodium tartrate 0.4, purified water 90, and glycerol 8 in parts by weight of a composite aloe hydrogel fixing layer.
Example 5:
the hydrogel scar-removing patch in embodiment 2 is prepared by mixing 1.5 parts by weight of aloe extract, 15 parts by weight of neutralized sodium polyacrylate, 0.1 part by weight of aluminum glycoxide, 0.3 part by weight of disodium edetate, 0.4 part by weight of sodium tartrate, 90 parts by weight of purified water and 6 parts by weight of glycerin in the composite aloe hydrogel fixing layer. The aloe extract is prepared by freeze drying aloe at low temperature for 8 hr, taking out, soaking in alcohol water solution at low temperature, and extracting.
Example 6:
a preparation method of a hydrogel scar removing paste comprises the steps of taking out medical silicone gel A and medical silicone gel B according to the proportion of 1:1.5-1:2, slowly pouring the silicone gel B into the silicone gel A, stirring at the speed of 200-400 r/min, and controlling the temperature at 28-35 ℃; the vacuum degree is-0.1 MPa, the stirring time is 30-50 minutes, and the stirring is finished; secondly, standing, pouring into a mould, and vulcanizing by an infrared dryer at the vulcanization temperature of 60-70 ℃ for 2-5 minutes; thirdly, dissolving 10-20 parts by mass of medical grade neutralization sodium polyacrylate in 5-8 parts by mass of glycerol, stirring for 2-3 minutes at the rotating speed of 600-; fourthly, 90 parts by mass of purified water is used for dissolving 0.4 to 0.5 part by mass of sodium tartrate and 1 to 2 parts by mass of aloe extract, then the mixture is poured into the glycerol suspension, the vacuum is controlled to be between 0.08 and 0.1MPa, the stirring speed is 1200 and 1400 revolutions per minute, and the temperature is set to be between 30 and 35 ℃. Stirring for 8-10 min, pouring into a mold for curing, placing in a curing chamber for curing, and taking out after curing at the temperature of 32-45 ℃ and the humidity of 40-70% for 600-1200 min; and fifthly, arranging the samples obtained in the steps 1, 2, 3 and 4 according to the sequence of a back lining layer, a composite aloe hydraulic fixing layer and a silicone gel film layer from bottom to top, and then covering a polypropylene film stripping layer to obtain the final product. The product and the method have a synergistic effect in combination, and a large number of experiments show that anaphylactic reaction cannot occur, so that the occurrence of side effects is reduced.
Example 7:
the preparation method of the hydrogel scar-removing patch in embodiment 6 includes the first step of taking out the medical silicone gel A and the medical silicone gel B according to the ratio of 1:1, slowly pouring the medical silicone gel B into the medical silicone gel A, and stirring at the speed of 200 rpm and the temperature of 28 ℃; the vacuum degree is-0.1 MPa, the stirring time is 30 minutes, and the stirring is finished; secondly, standing, pouring into a mold, and vulcanizing by an infrared dryer at the vulcanization temperature of 60 ℃ for 2 minutes; thirdly, dissolving 10-20 parts by weight of medical grade neutralization sodium polyacrylate in 5-8 parts by weight of glycerin, stirring for 2 minutes at the rotating speed of 600 revolutions per minute, standing, adding 0.1 part by weight of dihydroxyaluminum glycinate and 0.3 part by weight of disodium ethylenediamine tetraacetic acid, and continuing stirring for 6 minutes at the stirring speed of 1200 revolutions per minute to prepare glycerin suspension; fourthly, 90 parts by mass of purified water is used for dissolving 0.4 part by mass of sodium tartrate and 1 part by mass of aloe extract, then the mixture is poured into the glycerol suspension, the vacuum is controlled at-0.08 MPa, the stirring speed is 1200 r/min, and the temperature is set to be 30 ℃. Stirring for 8-minutes, pouring into a mold for curing, placing in a curing chamber for curing, and taking out after curing at the temperature of 32 ℃ and the humidity of 40% for 600 minutes; and fifthly, arranging the samples obtained in the steps 1, 2, 3 and 4 according to the sequence of a back lining layer, a composite aloe hydraulic fixing layer and a silicone gel film layer from bottom to top, and then covering a polypropylene film stripping layer to obtain the final product.
Example 7:
the preparation method of the hydrogel scar-removing patch in embodiment 6 includes the first step of taking out medical silicone gel A and medical silicone gel B according to a ratio of 1.5:2, slowly pouring the medical silicone gel B into the medical silicone gel A, and stirring at a speed of 400 rpm and a temperature of 35 ℃; the vacuum degree is-0.1 MPa, the stirring time is 50 minutes, and the stirring is finished; secondly, standing, pouring into a mold, and vulcanizing by an infrared dryer at the vulcanization temperature of 70 ℃ for 5 minutes; thirdly, dissolving 20 parts by weight of medical grade neutralization sodium polyacrylate in 5-8 parts by weight of glycerin, stirring for 3 minutes at the rotating speed of 800 revolutions per minute, standing, adding 0.2 part by weight of dihydroxyaluminum glycinate and 0.5 part by weight of disodium ethylene diamine tetraacetate, continuing stirring for 8 minutes, and preparing glycerin suspension at the stirring speed of 1400 revolutions per minute; fourthly, 90 parts by mass of purified water is used for dissolving 0.5 part by mass of sodium tartrate and 2 parts by mass of aloe extract, then the mixture is poured into the glycerol suspension, the vacuum is controlled at 0.1MPa, the stirring speed is 1400 revolutions per minute, and the temperature is set to be 35 ℃. Stirring for 10 minutes, pouring into a mold for curing, placing in a curing chamber for curing, and taking out after curing at 45 ℃ and 70% of humidity for 1200 minutes; and fifthly, arranging the samples obtained in the steps 1, 2, 3 and 4 according to the sequence of a back lining layer, a composite aloe hydraulic fixing layer and a silicone gel film layer from bottom to top, and then covering a polypropylene film stripping layer to obtain the final product.
Example 7:
the preparation method of the hydrogel scar-removing patch in embodiment 6 includes the first step of taking out medical silicone gel A and medical silicone gel B according to a ratio of 1:1.5, slowly pouring the medical silicone gel B into the medical silicone gel A, and stirring at a speed of 300 revolutions per minute and a temperature of 30 ℃; the vacuum degree is-0.1 MPa, the stirring time is 40 minutes, and the stirring is finished; secondly, standing, pouring into a mold, and vulcanizing by an infrared dryer at 65 ℃ for 3 minutes; thirdly, dissolving medical grade neutralization sodium polyacrylate with the mass part of 15 in 7 of glycerin, stirring for 2.5 minutes at the rotating speed of 700 r/min, standing, adding 0.15 part of dihydroxyaluminum glycinate and 0.4 part of disodium ethylene diamine tetraacetate with the mass part, continuing stirring for 7 minutes, and preparing glycerin suspension at the stirring speed of 1300 r/min; fourthly, 90 parts by mass of purified water is used for dissolving 0.45 part by mass of sodium tartrate and 1.5 parts by mass of aloe extract, then the mixture is poured into the glycerol suspension, the vacuum is controlled at-0.09 MPa, the stirring speed is 1300 r/min, and the temperature is set to be 35 ℃. Stirring for 9 minutes, pouring into a mold for curing, placing in a curing chamber for curing, and taking out after curing at the temperature of 40 ℃ and the humidity of 50% for 800 minutes; and fifthly, arranging the samples obtained in the steps 1, 2, 3 and 4 according to the sequence of a back lining layer, a composite aloe hydraulic fixing layer and a silicone gel film layer from bottom to top, and then covering a polypropylene film stripping layer to obtain the final product.
Claims (1)
1. The preparation method of the hydrogel scar-removing paste is characterized in that the hydrogel scar-removing paste comprises the following components: the aloe hydrogel fixing layer is connected with the silicone gel film, and the polypropylene film stripping layer is arranged on the silicone gel film; the composite aloe hydrogel fixed layer comprises 1-2 parts by weight of aloe extract, 10-20 parts by weight of neutralized sodium polyacrylate, 0.1 part by weight of aluminum glycoxide, 0.3 part by weight of disodium ethylene diamine tetraacetate, 0.4 part by weight of sodium tartrate, 90 parts by weight of purified water and 5-8 parts by weight of glycerol; firstly, taking out medical silicone gel A and medical silicone gel B according to the proportion of 1:1.5-1:2, slowly pouring the silicone gel B into the silicone gel A, and stirring at the speed of 200-400 r/min and the temperature of 28-35 ℃; the vacuum degree is-0.1 MPa, the stirring time is 30-50 minutes, and the stirring is finished; secondly, standing, pouring into a mold, and vulcanizing by an infrared dryer at the vulcanization temperature of 60-70 ℃ for 2-5 minutes; thirdly, dissolving 10-20 parts by mass of medical grade neutralization sodium polyacrylate in 5-8 parts by mass of glycerin, stirring for 2-3 minutes at the rotation speed of 600-; fourthly, 90 parts by mass of purified water is dissolved in 0.4 part by mass of sodium tartrate and 1-2 parts by mass of aloe extract and then poured into the glycerol suspension, the vacuum is controlled to be-0.08 to 0.1MPa, the stirring speed is 1200 and 1400 revolutions per minute, and the temperature is set to be 30 to 35 ℃; stirring for 8-10 min, pouring into a mold for curing, placing in a curing chamber for curing, and taking out after curing temperature is 32-45 ℃, humidity is 40-70%, and curing time is 600-1200 min; fifthly, arranging a back lining layer, a composite aloe hydraulic fixing layer and a silicone gel film layer in sequence from bottom to top, and then covering a polypropylene film stripping layer to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610350314.3A CN105920653B (en) | 2016-05-25 | 2016-05-25 | Hydrogel scar removing patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610350314.3A CN105920653B (en) | 2016-05-25 | 2016-05-25 | Hydrogel scar removing patch and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105920653A CN105920653A (en) | 2016-09-07 |
| CN105920653B true CN105920653B (en) | 2020-10-27 |
Family
ID=56841083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610350314.3A Expired - Fee Related CN105920653B (en) | 2016-05-25 | 2016-05-25 | Hydrogel scar removing patch and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105920653B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110478519A (en) * | 2019-06-24 | 2019-11-22 | 武汉兵兵药业有限公司 | One kind is for soft tissue surface of a wound scar repair hydrogel dressing and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394116B (en) * | 2013-08-21 | 2015-03-11 | 彭长生 | Hydrogel dressing capable of promoting wound healing and preparation method thereof |
| CN104288828B (en) * | 2014-10-29 | 2015-10-28 | 东莞市达庆医疗器械有限公司 | A kind of medical bio presses down scar reduce wrinkle dressing and preparation method thereof |
| CN104983495A (en) * | 2015-08-10 | 2015-10-21 | 南阳市汇博生物技术有限公司 | Positive pressure silicon gel elastic scar eliminating band and preparation method thereof |
-
2016
- 2016-05-25 CN CN201610350314.3A patent/CN105920653B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN105920653A (en) | 2016-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI398275B (en) | Skin wound dressing and manufacturing method thereof | |
| CN109045349A (en) | A kind of hydrogel skin wound dressing and preparation method thereof that antibacterial heal-promoting closes | |
| CN107050048B (en) | Cold compress patch and preparation method thereof | |
| CN108014366A (en) | A kind of marine organism material composite hydrogel dressing and preparation method thereof | |
| CN111632187B (en) | Biodegradable medical dressing and preparation method thereof | |
| CN108904421A (en) | A kind of microneedle patch and preparation method thereof for anti-ageing smoothing wrinkle | |
| US20190031787A1 (en) | Method for producing dried bio cellulose | |
| CN115998636B (en) | Gel mask containing recombinant humanized collagen and preparation method thereof | |
| CN104840428B (en) | A kind of hyaluronic acid-chitosan microballoon for being loaded with epidermal growth factor and its preparation method and application | |
| CN107261192A (en) | The bitter certain kind of berries glycosides F1 dressing and preparation method of a kind of promotion wound Scarless wound healing | |
| CN105920653B (en) | Hydrogel scar removing patch and preparation method thereof | |
| CN114949329B (en) | Preparation method of surface modified silk fibroin-aloin double-layer fiber membrane | |
| CN105169317A (en) | Preparation method of scar-removing ointment | |
| CN112841620B (en) | High-yield and high-activity black fungus dry powder and preparation method thereof | |
| CN108853369B (en) | Preparation method and application of natural plant antibacterial liquid PAMs hydrogel patch | |
| KR20140048063A (en) | Manifacturing method of dried bio-cellulose | |
| US5773034A (en) | Cutaneous rejuvenating and healing product, method for its manufacture and uses thereof | |
| CN113577375A (en) | Medical sterile foam dressing and preparation method thereof | |
| CN107080856B (en) | Bacterial cellulose-chitosan-laponite composite wound dressing and preparation method thereof | |
| CN110623946A (en) | Preparation method of double-layer skin repair membrane based on hydrophilicity and hydrophobicity | |
| CN109498562B (en) | Emergency burn care solution and preparation method thereof | |
| CN108210983A (en) | A kind of nasal cavity is grafted hyaluronic acid sponge and preparation method thereof with agarose | |
| CN113521380B (en) | Rapid polymerization hydrogel material and preparation method and application thereof | |
| CN114028299A (en) | Fibrous ointment for wound surface nursing and preparation method thereof | |
| TWI655005B (en) | Thermal wound dressing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20201027 Termination date: 20210525 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |