CN105920626A - Ultrasonic coupling agent for B-ultrasound and preparation process thereof - Google Patents
Ultrasonic coupling agent for B-ultrasound and preparation process thereof Download PDFInfo
- Publication number
- CN105920626A CN105920626A CN201610484960.9A CN201610484960A CN105920626A CN 105920626 A CN105920626 A CN 105920626A CN 201610484960 A CN201610484960 A CN 201610484960A CN 105920626 A CN105920626 A CN 105920626A
- Authority
- CN
- China
- Prior art keywords
- coupling agent
- ultrasonic
- ultrasonic coupling
- stirring
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007822 coupling agent Substances 0.000 title claims abstract description 70
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 238000002604 ultrasonography Methods 0.000 title abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 67
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims abstract description 49
- 229960003500 triclosan Drugs 0.000 claims abstract description 49
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 28
- 239000008213 purified water Substances 0.000 claims abstract description 26
- 238000003756 stirring Methods 0.000 claims description 61
- 239000000499 gel Substances 0.000 claims description 52
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 33
- 239000000203 mixture Substances 0.000 claims description 32
- 239000004902 Softening Agent Substances 0.000 claims description 26
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 16
- 229920002125 Sokalan® Polymers 0.000 claims description 16
- 229960001631 carbomer Drugs 0.000 claims description 16
- 238000005516 engineering process Methods 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 16
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 10
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 claims description 9
- 239000002002 slurry Substances 0.000 claims description 7
- 229920001661 Chitosan Polymers 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- WUGQZFFCHPXWKQ-UHFFFAOYSA-N Propanolamine Chemical compound NCCCO WUGQZFFCHPXWKQ-UHFFFAOYSA-N 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 230000008961 swelling Effects 0.000 claims description 5
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 239000004368 Modified starch Substances 0.000 claims description 3
- 229920000881 Modified starch Polymers 0.000 claims description 3
- 229940043279 diisopropylamine Drugs 0.000 claims description 3
- BEGBSFPALGFMJI-UHFFFAOYSA-N ethene;sodium Chemical group [Na].C=C BEGBSFPALGFMJI-UHFFFAOYSA-N 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 235000019426 modified starch Nutrition 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 48
- 235000011187 glycerol Nutrition 0.000 abstract description 16
- 241000700605 Viruses Species 0.000 abstract description 10
- 230000008878 coupling Effects 0.000 abstract description 8
- 238000010168 coupling process Methods 0.000 abstract description 8
- 238000005859 coupling reaction Methods 0.000 abstract description 8
- 239000000523 sample Substances 0.000 abstract description 4
- 230000001808 coupling effect Effects 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 239000013078 crystal Substances 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- 239000006184 cosolvent Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 230000008719 thickening Effects 0.000 description 4
- 241000725303 Human immunodeficiency virus Species 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 206010064097 avian influenza Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000709721 Hepatovirus A Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- -1 glycerol Chemical compound 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000711798 Rabies lyssavirus Species 0.000 description 1
- 241000195474 Sargassum Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an ultrasonic coupling agent for B-ultrasound and a preparation process thereof. The ultrasonic coupling agent is prepared from the following components in percentage by mass: 0.2 to 10 percent of water-soluble triclosan, 0.1 to 10 percent of a moisturizing softener, 0.2 to 8 percent of a neutralizer, 0.5 to 8 percent of a gel, and the balance of purified water. In the mode, the coupling agent gel obtained by the technical scheme of the invention is clear and transparent, does not have air bubbles and can meet the requirements on clinical ultrasonic coupling, so that a coupling effect between a part of an examinee and an ultrasonic probe is ideal; moreover, the components of the ultrasonic coupling agent disclosed by the invention do not contain glycerin, so that bacteria and viruses are prevented from being nourished.
Description
Technical field
The present invention relates to medical auxiliary agent field, particularly relate to a kind of medical super with use when treating for ultrasonic diagnosis
Acoustic couplant and preparation method thereof.
Background technology
B ultrasound is the detecting instrument of wide clinical application, and ultrasonic coupling agent is a kind of special preparation, and it is in function
On be auxiliary and the extension of diagnostic apparatus, and be the medical supplies similar to topical drug, cosmetics in usage.Ultrasonic coupling
Agent is used to be coated in patient and detects and make itself and air exclusion on the skin at position, and display checks the picture rich in detail of organ.Therefore want
Ultrasonic coupling agent is asked to have no skin irritation, easy-clear, do not damage the features such as instrument.Medical ultrasonic coupling agent should by clinic
By the difference of approach, Interventional couplant and non-invasi couplant can be divided into.The former refers to donor chamber and mucosa to carry out ultrasonic
Diagnosis and the aseptic couplant for the treatment of, the latter refers to the couplant being intended on skin carrying out diagnosis.
Being mainly composed of of non-invasi couplant of the prior art: triclosan, propylene glycol, glycerol, triethanolamine,
Carbomer etc..In the ultrasonic coupling agent of this constituents, triclosan is due to the characteristic of its molecular structure, carbon molecule and chlorine molecule relatively
Many, there is fat-soluble characteristic, water insoluble, mainly it is dissolved in the carbomer mixed liquor adding the solubilizing agent such as propylene glycol and glycerol
In.Owing to solvent containing more cosolvent, therefore dissolve the mixed liquor after triclosan and presented opaque gel.And in reality
When border produces, in addition it is also necessary to be added thereto to purified water and be diluted, but once add purified water dilution and be easily caused triclosan precipitation,
So that couplant gel muddiness is opaque, affect ultrasonic transmission wave, make between the position of tester and ultrasonic probe, to couple effect
The most undesirable.Therefore, triclosan how is made fully to dissolve in the preparation process of ultrasonic coupling agent, it is ensured that couplant gel clear
Clear transparent, bubble-free is the most muddy, the always critical technological point in Interventional and non-invasi couplant.
In addition to the characteristic that triclosan itself is not readily dissolved in water, in preparation process, the cosolvent of triclosan generally uses
Be glycerol i.e. glycerol, but can synchronize after glycerol hydrotropy to produce a large amount of bubble, its reason is: the characteristic of glycerol molecule formula, easily
Produce bubble；Simultaneously also in that glycerol pH value is neutrality slightly meta-acid, and it is easily generated bubble after carbomer mixing.It addition, it is new
Research shows, the goods containing glycerol easily nourish virus, and " people infects H7N9 bird flu diagnosis and treatment to state's food medicine prison tool second edition in 2013
Scheme " in, announce H7N9 bird flu virus and can survive in glycerinated goods more than 1 year.Prior art makes clinically
The ultrasonic coupling agent overwhelming majority be that a class produces, for non-sterile requirement, production environment is not at cleaning shop but common ring
Workshop under border, easily adheres to various microorganisms, causes pathogen infection probability high, especially at glycerinated coupling in its production process
The risk that in mixture, bacterial virus exists is bigger.
Therefore, prior art is badly in need of a kind of triclosan can fully not separate out and the most glycerinated intervention and non-Jie by solvent
Entering property couplant.
Summary of the invention
For above-mentioned deficiency of the prior art, the main object of the present invention is to provide a kind of with the replacement of water solublity triclosan
The B ultrasonic ultrasonic coupling agent of traditional water-insoluble triclosan, and this ultrasonic coupling agent is without glycerol, and this ultrasonic coupling agent is solidifying
Glue is as clear as crystal, not bubbles, and owing to without glycerol, effectively prevent glycerol and easily nourishing the risk of virus.
For achieving the above object, the technical scheme that the present invention provides is: a kind of B ultrasonic ultrasonic coupling agent, described ultrasonic coupling
Mixture includes following composition by mass percentage: water solublity triclosan 0.2-10%, moisturizing softening agent 0. 1-10%, nertralizer
0.2-8%, gel 0.5-8%, surplus is purified water.
Preferably, described ultrasonic coupling agent includes following composition by mass percentage: water solublity triclosan 1-10%, moisturizing
Softening agent 0.1-8%, nertralizer 0.5-6%, gel 0.5-4%, surplus is purified water.
Preferably, described ultrasonic coupling agent includes following composition by mass percentage: water solublity triclosan 2-8%, moisturizing are soft
Agent 0.2-7%, nertralizer 0.5-5%, gel 0.5-3%, surplus is purified water.
Preferably, in described ultrasonic coupling agent, described moisturizing softening agent is propylene glycol, Polyethylene Glycol, ethylenediaminetetraacetic acid
At least one in sodium, disodiumedetate.
Preferably, in described ultrasonic coupling agent, described nertralizer be triethanolamine, three b propanol amine, tromethane, two
At least one in isopropylamine.
Preferably, in described ultrasonic coupling agent, described gel is carbomer, gelatin, water-soluble chitosan, ethoxy fibre
At least one in dimension element, sodium alginate, modified starch.
Preferably, described ultrasonic coupling agent includes following composition by mass percentage: water solublity triclosan 2-10%, moisturizing
Softening agent 0.2-8%, nertralizer 0.5-6%, gel 0.5-4%, surplus is purified water.
B ultrasonic ultrasonic coupling agent of the present invention use water solublity triclosan (triclosan content is 10-15%) as sterilization
Agent, coordinates gel to be prepared as ultrasonic coupling agent.
The invention also discloses the preparation technology of a kind of B ultrasonic ultrasonic coupling agent, described preparation technology operates as follows:
Step 1: first add gel, nertralizer and purified water by mass percentage in stirring container, do not open vacuum, stirring
Mixing 30-60 min, is evenly stirred until complete swelling；Then water solublity triclosan and moisturizing softening agent are mixed in another container
Close uniformly, be then added to stir in container by both mixture the most mixed, obtain mixed liquor；
Step 2: in the case of not starting blender, by the mixed liquor evacuation in the stirring container in step 1；
Step 3: start the blender of stirring container with 30-40 turn/mixing speed of min stirring evacuation after mixed liquor, limit
Stirring limit evacuation, after continuously stirred 4-8min, then uses 70-90 to turn the/mixing speed stirring of min, continuously stirred 7-
After 10min, obtain couplant gel.
Preferably, in this preparation technology, before stirring raw material, the stirring-head of blender is replaced by wide slurry head stirring.
In the present invention in the manufacturing process of couplant gel, it then follows " having the principle of powder not evacuation ", " have air not
The principle of stirring " carry out evacuation and stirring operation.
In B ultrasonic ultrasonic coupling agent of the present invention, water solublity triclosan is that the principle by physics solubilising is by trichlorine
Life becomes water solublity on the premise of unmodified, and its characteristic and advantage are as follows: without cosolvent, completely soluble, can prepare pure
Positive aqueous product；Nonirritant, has no side effect, and bactericidal effect is notable；Compatibility is good, can be with most material combinations；Make
With convenient, need not heat or other pretreatment.The most easy to use, and because be more easy to be uniformly dispersed, increase sterilization
Specific surface area, thus further increase the bactericidal property of triclosan, to causing infection or pathogenicity, Gram-positive and the moon
Property bacterium, fungus, yeast and virus (such as hepatitis A virus (HAV), hepatitis B virus, rabies virus, HIV (human immunodeficiency virus) HIV etc.) have widely
Kill and inhibitory action, there is quick-acting and specially good effect dual function.Water solublity triclosan is completely dissolved in water, can apply to day
Change in each fields such as product, sterile products and medicine.
In the present invention, it is preferred that described ultrasonic coupling agent includes following composition: water solublity triclosan, propylene glycol, three second
Hydramine, carbomer.
In the present invention, propylene glycol, as softening wetting agent, itself is also good flux simultaneously, can be further
Assist the dissolving dispersion of water solublity triclosan.
In the present invention, triethanolamine as nertralizer, by by gel carbomer with become salt, carbomer is quick to ion
Sense, can make molecule thickening because repulsion opens of curling.
In the present invention, carbomer, as gel, for high molecular polymer, as gel-type vehicle, has thickening property, suspension
Property, moisture retention, and good stability.
The mechanism of action of the present invention: the water solublity triclosan in this couplant, is directly dissolved in water, it is not necessary to add cosolvent,
Its sterilizing wide spectrum, can kill exist in body surface, mucosa and body cavities staphylococcus aureus, escherichia coli,
Candida albicans, bacillus pyocyaneus, Hemolytic streptococcus and fungus, yeast and virus etc.；And as the third of moisturizing softening agent
Glycol, that further assists water solublity triclosan is uniformly dissolved dispersion；High molecular polymer carbomer, as gel-type vehicle,
There is thickening property, suspension, moisture retention, and good stability；Nertralizer triethanolamine by by gel carbomer with become salt,
Carbomer, to ion-sensitive, can make molecule thickening because repulsion opens of curling.In this product, by avoiding interpolation glycerol (i.e.
Glycerol), effectively reduce generation bubble in gel, it is therefore prevented that the two-way moisture absorption of glycerol, stop glycerinated goods easily to nourish
Virus particularly H7N9 bird flu virus；And in the manufacturing process of product, use the principle of " having air not stir ", in conjunction with
The wide oar stirring-head of blender, with the slowest rear fast speed stirring, can reduce bubble wall built-up pull in relative time, space
The ratio that ruptures again, frequency, effectively prevention and reduce and produce bubble in gel；In addition the characteristic that water solublity triclosan is hydrophilic, coupling
Mixture gel is as clear as crystal, the good air intercepted between Ultrasonic-B probe or treatment head and skin and mucosa so that image is clear
Clear, coupling diagnosis effect is good.
In technical solution of the present invention, owing to using water solublity triclosan, substitute water-insoluble triclosan, by physics solubilising
Change its capillary principle, triclosan is become on the premise of unmodified water solublity, the most easy to use, it is easier to point
Dissipate uniformly, add the specific surface area of sterilization, thus further increase the bactericidal property of triclosan.Prepared ultrasonic coupling
Agent is completely dissolved in water, it is not necessary to add any chemical cross-linking agent again；And because being physics increase-volume, so it is adding purification
During water dilution, do not produce triclosan precipitation phenomenon, thus the gel prepared is as clear as crystal.
Due to the sticky nature of ultrasonic coupling agent gel, under non-vacuum, in gel whipping process, air mixes it
Between, bubble is ruptured by wall built-up pull again, can produce some micro-bubbles, and these are mingled in the bubble in viscous gel, extraction
During vacuum, it is difficult to twitch, i.e. enables extraction, also can extract unclean because of the sticky nature of gel, also can remaining a large amount of small gas
Bubble, thus cause the couplant gel of preparation to there is a large amount of fine gas bubbles, impact uses.Therefore, in this case, the present invention
Innovate preparation technology, overcome the deficiency in prior art preparation technology.In technical solution of the present invention, add at raw material
Finish, before being stirred, open vacuum pump extracting vacuum in advance, and first stir with bottom gear, synchronize extracting vacuum simultaneously；And
In technical scheme disclosed in this invention, wide slurry head stirring taked by blender, this wide slurry head stirring can when extracting vacuum,
Ratio and frequency that bubble wall built-up pull ruptures again is reduced in relative time, space；Stirring start with stirring at low speed, be also for
Ratio and frequency that bubble wall built-up pull ruptures again is reduced in relative time.So in order to reduce gel in technical solution of the present invention
In bubble, improve gel coupling effect, propose " have powder not evacuation, have air not stir " principle, at gel
After dissolving fully, first extracting vacuum before stirring, select width to starch stirring-head elder generation low speed high-speed stirred more again.The coupling being eventually fabricated
Mixture gel is as clear as crystal, is substantially free of bubble.
The invention has the beneficial effects as follows: B ultrasonic ultrasonic coupling agent preparation process of the present invention is simply, easily operate；Obtained coupling
Mixture gel is as clear as crystal, bubble-free, it is possible to meets clinical ultrasound coupling demand, makes between the position of tester and ultrasonic probe
Coupling effect is preferable；And in the ultrasonic coupling agent composition of the present invention without glycerol, it is to avoid nourishing bacterial virus.
Detailed description of the invention
Below presently preferred embodiments of the present invention is described in detail so that advantages and features of the invention can be easier to by
It will be appreciated by those skilled in the art that thus protection scope of the present invention is made apparent clear and definite defining.
The embodiment of the present invention includes:
Embodiment 1: a kind of B ultrasonic ultrasonic coupling agent, described ultrasonic coupling agent includes following composition by mass percentage: water solublity
Triclosan 0.2-10%, moisturizing softening agent 0.1-10%, nertralizer 0.2-8%, gel 0.5-8%, surplus is purified water.
In the present embodiment, moisturizing softening agent is propylene glycol, Polyethylene Glycol, sodium ethylene diamine tetracetate, ethylenediaminetetraacetic acid two
At least one in sodium；Nertralizer is at least one in triethanolamine, three b propanol amine, tromethane, diisopropylamine；
Gel is at least one in carbomer, gelatin, water-soluble chitosan, hydroxyethyl cellulose, sodium alginate, modified starch.
Embodiment 2: a kind of B ultrasonic ultrasonic coupling agent, described ultrasonic coupling agent includes following composition by mass percentage: water
Dissolubility triclosan 1-10%, moisturizing softening agent 0.1-8%, nertralizer 0.5-6%, gel 0.5-4%, surplus is purified water.
Embodiment 3: described ultrasonic coupling agent includes following composition by mass percentage: water solublity triclosan 2-8%, moisturizing
Softening agent 0.2-7%, nertralizer 0.5-5%, gel 0.5-3%, surplus is purified water.
Embodiment 4: a kind of B ultrasonic ultrasonic coupling agent, described ultrasonic coupling agent includes following composition by mass percentage: water
Dissolubility triclosan 2-10%, moisturizing softening agent 0.2-8%, nertralizer 0.5-6%, gel 0.5-4%, surplus is purified water.
Embodiment 5: a kind of B ultrasonic ultrasonic coupling agent, described ultrasonic coupling agent includes following composition by mass percentage: water
Dissolubility triclosan 2.5%, moisturizing softening agent 0.5%, nertralizer 1 %, gel 1%, surplus is purified water.
Embodiment 6: a kind of B ultrasonic ultrasonic coupling agent, described ultrasonic coupling agent includes following composition by mass percentage: water
Dissolubility triclosan 2%, moisturizing softening agent propylene glycol 0.4%, nertralizer triethanolamine 0.8%, gel 1%, surplus is purified water.
Embodiment 7: a kind of B ultrasonic ultrasonic coupling agent, described ultrasonic coupling agent includes following composition by mass percentage: water
Dissolubility triclosan 3%, moisturizing softening agent propylene glycol 0.8%, nertralizer triethanolamine 0.8%, gel carbomer 1.5%, surplus is
Purified water.
Embodiment 8: a kind of B ultrasonic ultrasonic coupling agent, described ultrasonic coupling agent includes following composition by mass percentage: water
Dissolubility triclosan 3%, moisturizing softening agent Polyethylene Glycol 0.8%, nertralizer three b propanol amine 0.8%, gel water-soluble chitosan
1.5%, surplus is purified water.
Embodiment 9: a kind of B ultrasonic ultrasonic coupling agent, described ultrasonic coupling agent includes following composition by mass percentage: water
Dissolubility triclosan 2%, moisturizing softening agent Polyethylene Glycol 0.8%, nertralizer three b propanol amine 6%, gel water-soluble chitosan 4%,
Surplus is purified water.
Embodiment 10: a kind of B ultrasonic ultrasonic coupling agent, described ultrasonic coupling agent includes following composition by mass percentage:
Water solublity triclosan 10%, moisturizing softening agent sodium ethylene diamine tetracetate alcohol 8%, nertralizer tromethane 0.5%, gel Sargassum
Acid sodium 4%, surplus is purified water.
Embodiment 11: a kind of B ultrasonic ultrasonic coupling agent, described ultrasonic coupling agent includes following composition by mass percentage:
Water solublity triclosan 0.0001%, moisturizing softening agent disodiumedetate 0.001%, nertralizer diisopropylamine 0.5%, solidifying
Colloid hydroxyethyl cellulose 3%, surplus is purified water.
Embodiment 12: the preparation technology of a kind of B ultrasonic ultrasonic coupling agent, described preparation technology operates as follows:
Before operation, the stirring-head in stirring container is changed to wide slurry head stirring；Concrete operations are as follows:
First, in stirring container, add gel, nertralizer and purified water by mass percentage, do not open vacuum, stirring mixing
30-60 min, is evenly stirred until complete swelling；Then water solublity triclosan and moisturizing softening agent are mixed all in another container
Even, it is then added to stir in container by both mixture the most mixed, obtains mixed liquor；
Then, in the case of not starting blender, by the mixed liquor extracting vacuum in stirring container；
Followed by start the blender of stirring container with 30-40 turn/mixing speed of min stirring evacuation after mixed liquor, limit
Stirring limit evacuation, after continuously stirred 4-8min, then uses 70-90 to turn the/mixing speed stirring of min, continuously stirred 7-
After 10min, obtain couplant gel.
Embodiment 13: the preparation technology of a kind of B ultrasonic ultrasonic coupling agent, described preparation technology operates as follows:
Before operation, the stirring-head in stirring container is changed to wide slurry head stirring；Concrete operations are as follows:
First, in stirring container, gel carbomer 1%, nertralizer triethanolamine 0.8% and enough are added by mass percentage
Purified water, does not open vacuum, stirring mixing 30 min, is evenly stirred until complete swelling；Then by water solublity triclosan 2% and moisturizing
Softening agent propylene glycol 0.6% is mix homogeneously in another container, is then added to stir container by both mixture the most mixed
In, obtain mixed liquor；
Then, in the case of not starting blender, by the mixed liquor evacuation in stirring container, take out about 30min to stirring
In vacuum state in container；
Stirring the mixed liquor after evacuation followed by the blender starting stirring container with the mixing speed of 40 turns/min, limit is stirred
Limit evacuation, after continuously stirred 5-6min, then uses the mixing speed stirring of 80 turns/min, after continuously stirred 7-8min,
To couplant gel.
Embodiment 14: the preparation technology of a kind of B ultrasonic ultrasonic coupling agent, described preparation technology operates as follows:
Before operation, be that wide slurry head stirs by the stirring-head of blender in stirring container；Concrete operations are as follows:
First, in stirring container, gel carbomer 0.8%, nertralizer triethanolamine 0.8% and foot are added by mass percentage
Amount purified water, does not open vacuum, stirring mixing 60 min, is evenly stirred until complete swelling；Then by water solublity triclosan 2.5% He
Both mixture the most mixed are then added to stirring by moisturizing softening agent propylene glycol 0.5% mix homogeneously in another container
In container, obtain mixed liquor；
Then, in the case of not starting blender, by the mixed liquor evacuation in stirring container, take out about 30min to stirring
In vacuum state in container；
Stirring the mixed liquor after evacuation followed by the blender starting stirring container with the mixing speed of 30 turns/min, limit is stirred
Limit evacuation, after continuously stirred 6-7min, then uses the mixing speed stirring of 70 turns/min, after continuously stirred 8-10min,
To couplant gel.
The product of Example 13 preparation carries out performance detection test, and testing result is shown in Table 1, table 2:
The foregoing is only embodiments of the invention, not thereby limit the scope of the claims of the present invention, every present invention of utilization says
Equivalent structure or equivalence flow process that bright book content is made convert, or are directly or indirectly used in other relevant technical fields, all
In like manner it is included in the scope of patent protection of the present invention.
Claims (8)
1. a B ultrasonic ultrasonic coupling agent, it is characterised in that described ultrasonic coupling agent includes following composition by mass percentage:
Water solublity triclosan 0.2-10%, moisturizing softening agent 0.1-10%, nertralizer 0.2-8%, gel 0.5-8%, surplus is purified water.
B ultrasonic ultrasonic coupling agent the most according to claim 1, it is characterised in that described ultrasonic coupling agent presses percent mass
Than including following composition: water solublity triclosan 1-10%, moisturizing softening agent 0.1-8%, nertralizer 0.5-6%, gel 0.5-4%,
Surplus is purified water.
B ultrasonic ultrasonic coupling agent the most according to claim 2, it is characterised in that described ultrasonic coupling agent presses percent mass
Than including following composition: water solublity triclosan 2-8%, moisturizing softening agent 0.2-7%, nertralizer 0.5-5%, gel 0.5-3%, remaining
Amount is purified water.
4. according to described B ultrasonic ultrasonic coupling agent arbitrary in claim 1-3, it is characterised in that in described ultrasonic coupling agent,
Described moisturizing softening agent is at least one in propylene glycol, Polyethylene Glycol, sodium ethylene diamine tetracetate, disodiumedetate.
5. according to described B ultrasonic ultrasonic coupling agent arbitrary in claim 1-3, it is characterised in that in described ultrasonic coupling agent,
Described nertralizer is at least one in triethanolamine, three b propanol amine, tromethane, diisopropylamine.
6. according to described B ultrasonic ultrasonic coupling agent arbitrary in claim 1-3, it is characterised in that in described ultrasonic coupling agent,
Described gel is at least in carbomer, gelatin, water-soluble chitosan, hydroxyethyl cellulose, sodium alginate, modified starch
Kind.
7. the preparation technology of a B ultrasonic ultrasonic coupling agent, it is characterised in that described preparation technology operates as follows:
Step 1: first add gel, nertralizer and purified water by mass percentage in stirring container, do not open vacuum, stirring
Mixing 30-60 min, is evenly stirred until complete swelling；Then water solublity triclosan and moisturizing softening agent are mixed in another container
Close uniformly, be then added to stir in container by both mixture the most mixed, obtain mixed liquor；
Step 2: in the case of not starting blender, by the mixed liquor evacuation in the stirring container in step 1；
Step 3: start the blender of stirring container with 30-40 turn/mixing speed of min stirring evacuation after mixed liquor, limit
Stirring limit evacuation, after continuously stirred 4-8min, then uses 70-90 to turn the/mixing speed stirring of min, continuously stirred 7-
After 10min, obtain couplant gel.
The preparation technology of B ultrasonic ultrasonic coupling agent the most according to claim 7, it is characterised in that in described stirring container
The stirring-head of blender be wide slurry head stirring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610484960.9A CN105920626A (en) | 2016-06-28 | 2016-06-28 | Ultrasonic coupling agent for B-ultrasound and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610484960.9A CN105920626A (en) | 2016-06-28 | 2016-06-28 | Ultrasonic coupling agent for B-ultrasound and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105920626A true CN105920626A (en) | 2016-09-07 |
Family
ID=56829452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610484960.9A Pending CN105920626A (en) | 2016-06-28 | 2016-06-28 | Ultrasonic coupling agent for B-ultrasound and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105920626A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202100031556A1 (en) * | 2021-12-16 | 2023-06-16 | Claudio Bandini | ULTRASOUND GEL |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797391A (en) * | 2010-03-12 | 2010-08-11 | 苏州御芙蓉日化有限公司 | Disposable bactericidal medical ultrasonic couplant and preparation method thereof |
| CN102716503A (en) * | 2012-06-04 | 2012-10-10 | 周郗竹 | Medical ultrasonic coupling agent and preparation method thereof |
| CN103007305A (en) * | 2013-01-04 | 2013-04-03 | 山西康灵医疗器械有限公司 | Preparation method of transparent bactericidal medical ultrasonic coupling agent |
| CN104208726A (en) * | 2014-02-28 | 2014-12-17 | 张维芬 | Chitosan quaternary ammonium salt couplant and preparation method thereof |
| CN105193705A (en) * | 2015-09-17 | 2015-12-30 | 天津施普瑞生物科技有限公司 | Gel containing triclosan |
-
2016
- 2016-06-28 CN CN201610484960.9A patent/CN105920626A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797391A (en) * | 2010-03-12 | 2010-08-11 | 苏州御芙蓉日化有限公司 | Disposable bactericidal medical ultrasonic couplant and preparation method thereof |
| CN102716503A (en) * | 2012-06-04 | 2012-10-10 | 周郗竹 | Medical ultrasonic coupling agent and preparation method thereof |
| CN103007305A (en) * | 2013-01-04 | 2013-04-03 | 山西康灵医疗器械有限公司 | Preparation method of transparent bactericidal medical ultrasonic coupling agent |
| CN104208726A (en) * | 2014-02-28 | 2014-12-17 | 张维芬 | Chitosan quaternary ammonium salt couplant and preparation method thereof |
| CN105193705A (en) * | 2015-09-17 | 2015-12-30 | 天津施普瑞生物科技有限公司 | Gel containing triclosan |
Non-Patent Citations (1)
| Title |
|---|
| 鞠方涛 等: "一种医用超声耦合剂消毒凝胶杀菌效果和毒性观察", 《中国消毒学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202100031556A1 (en) * | 2021-12-16 | 2023-06-16 | Claudio Bandini | ULTRASOUND GEL |
| WO2023111973A1 (en) * | 2021-12-16 | 2023-06-22 | Bandini Claudio | Ultrasound gel |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102639129B (en) | Antimicrobial compositions containing free fatty | |
| TW201004572A (en) | Bacterial cellulose-containing formulations lacking a carboxymethyl cellulose component | |
| CN101612408A (en) | B ultrasonic couplant and preparation method | |
| CN104208726B (en) | Chitosan quaternary ammonium salt couplant and preparation method thereof | |
| CN104667304A (en) | Ultrasonic coupling agent and preparation method thereof | |
| WO2006079288A1 (en) | Use of human lysozyme for preparing cosmetics against acne | |
| CN105920626A (en) | Ultrasonic coupling agent for B-ultrasound and preparation process thereof | |
| CN103301049A (en) | Andrographis paniculata hand sanitizer and preparation method thereof | |
| WO2010097993A1 (en) | Salt-resistant thickener and cosmetic comprising same | |
| CN103893784B (en) | A kind of sterilization ultrasonic coupling agent and preparation method thereof | |
| CN105963723A (en) | B ultrasonic coupling agent and preparation technology thereof | |
| CN108186738A (en) | A kind of gynaecological gel of American-cockroach-extract-containing and preparation method thereof | |
| CN105148292A (en) | Medical ultrasonic coupling agent and preparation method thereof | |
| CN105031674A (en) | Disinfectant medical ultrasonic coupling agent and production process thereof | |
| CN105944118A (en) | Medicinal disinfection ultrasonic coupling agent and preparation method thereof | |
| CN116549675A (en) | Non-irritating medical ultrasonic coupling agent and preparation method thereof | |
| CN105106108A (en) | Supermolecule controlled/slow-release type salicylate formula and preparation technology thereof | |
| CN109846985A (en) | A kind of nasal cavity disease adjuvant treatment cleaning agent and preparation method thereof | |
| CN106178140B (en) | Pure natural water-soluble human body lubricant and preparation method and application thereof | |
| CN104721845A (en) | Disinfecting and sterilizing medical ultrasonic coupling agent with moisturizing and skin-moistening effects and preparation method of disinfecting and sterilizing medical ultrasonic coupling agent | |
| CN105147596B (en) | Water-soluble supermolecule salicylic acid gel technology | |
| CN113967192A (en) | Pharmaceutical composition for accelerating wound healing, preparation method and application thereof | |
| CN113768874A (en) | Novel compound iodine disinfectant and preparation method thereof | |
| CN106075500B (en) | A kind of fungicide and preparation method thereof for β-Ultrasound Room instrument | |
| CN109675068A (en) | A kind of medical ultrasonic coupling agent and preparation method thereof with sterilizing function |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160907 |