CN105920106A - Moxibustion cream traditional Chinese medicine compound composition for assisting thunder and fire moxibustion and preparation method thereof - Google Patents

Abstract

The invention provides a moxibustion cream traditional Chinese medicine compound composition for assisting thunder and fire moxibustion and a preparation method thereof. The moxibustion cream traditional Chinese medicine compound composition comprises, by weight, 1-3 parts of syzygium aromaticum, 1-3 parts of cortex cinnamomi and 1-3 parts of lamiophlomis rotata. The preparation method includes: taking the syzygium aromaticum and the cortex cinnamomi, adding water with the weight being 10 times of the weight of the syzygium aromaticum and the cortex cinnamomi, using a distillation method to extract volatile oil until the volatile oil does not increase any more, collecting the volatile oil for standby, and filtering the aqueous solution after the distillation to collect syzygium aromaticum and cortex cinnamomi filtrate; decocting the lamiophlomis rotata with water twice, combining the decoctions, and filtering to obtain lamiophlomis rotata filtrate, wherein the weight of the added water of each decocting is at least two times of the weight of the raw lamiophlomis rotata, and the time of each decocting is more than 1 hour; combining the obtained syzygium aromaticum and cortex cinnamomi filtrate and the obtained lamiophlomis rotata filtrate, and concentrating to obtain main medicine liquid extract; adding auxiliary materials into the volatile oil and the main medicine liquid extract, and well mixing to obtain gel or cream. The moxibustion cream traditional Chinese medicine compound composition has the advantages that the composition can assist heat to well permeate towards subcutaneous tissue and deep tissue during the thunder and fire moxibustion and promote medicine transdermal absorption so as to improve pain caused by soft tissue injury.

Description

A kind of moxibustion cream Traditional Chinese medicine compound composition assisting LEIHUO moxibustion moxibustion treatment and preparation method thereof

Technical field

The present invention designs technical field of Chinese medicines, a kind of moxibustion cream Traditional Chinese medicine compound composition assisting LEIHUO moxibustion moxibustion treatment and preparation method thereof.

Background technology

Chronic soft tissue injuries is pain caused is one of the principal indication of LEIHUO moxibustion moxibustion treatment.It includes the chronic injuries such as skeletal muscle, fascia, ligament, joint capsule, periosteum, fatty tissue, relate to whole body multiple location, multi-joint disease, most common such as disease about spine (cervical spondylosis, scapulohumeral periarthritis, lumbar muscle strain, prolapse of lumbar intervertebral disc) and extremity joint disease (knee joint osseous arthritis, rheumatoid arthritis, rheumatic arthritis, articular sprain, fracture surgery) etc..All there is aseptic inflammation in various degree in such disease, causes chronic pain recurrent exerbation.Chronic soft tissue injuries belongs to the traditional Chinese medical science " injury of tendon and muscle ", " numbness is sick " category, and pathogenesis is that wind-cold damp pathogen blocks meridians, or wound, overstrain cause muscle arteries and veins is impaired, and QI-blood circulation is smooth, stagnation of QI and blood may bring about pain；Or because of caused by liver and kidney deficiency, muscle arteries and veins loses supports, not Rong Ze pain；Liking temperature, be afraid of cold in such patient pain position, obtains hot, improve, belong to deficiency syndrome, cold syndrome more.

Chronic soft tissue injuries common method for the treatment of is as follows: (1) is administered orally nonsteroidal antipyretic analgesic, such as celecoxib, diclofenac sodium etc..(2) conventional oral Chinese medicine prescription has Radix Angelicae Pubescentis et Herba Taxilli Decoction, JINGUI SHENQI WAN, promoting blood circulation and stopping pain soup, XIAOHUOLUO DAN etc. according to different differentiation of symptoms and signs for classification of syndrome.(3) conventional externally applied ointment such as SHANGSHI ZHITONG GAO, discutient and analgesic plaster, compound Nanxing pain paste, strange positive cream etc..(4) acupuncture and moxibustion therapy: include acupuncture, moxibustion therapy, cup etc..Wherein moxibustion therapy is more generally used, as warming needle moxibustion, moxibustion box hang moxibustion, LEIHUO moxibustion, thermosensitive moxibustion etc..(5) naturopathy: such as medium-frequency pulse, ultrasonic, high frequency, low frequency, traditional Chinese medicine fumigating medicine etc..(6) minimally-invasive treatment: such as nerve block, pin cutter, radio frequency etc..But, although oral drugs can partly alleviate the pain of diseased region, but still have quite a few patient after using, can not preferably improve symptom, and meet cold, tired after substantially increase the weight of.Long-term Oral medicine also brings along degradation problem under gastrointestinal side effect, compliance.The middle effective ingredient percutaneous permeation of externally applied ointment is not enough, though easy to use, external there will be local skin anaphylaxis more repeatedly, causes patient's drug withdrawal.Naturopathy has certain immediate effectiveness, but the maintenance of curative effect is limited.Minimally-invasive treatment is fixed for part pain spot, the obvious patient of pain is preferable at the initial performances of the course for the treatment of, and the subsequent chronic aseptic inflammation occurred after repetitive therapy brings bigger trouble to treatment.

Acupuncture and moxibustion therapy gets more and more for chronic soft tissue injuries, and wherein moxibustion therapy is more generally used.Moxibustion therapy belongs to the category of thermotherapy, is played a role by multipaths such as heat radiation, light radiation, Drug Percutaneous Absorptions, can be effectively improved diseased region blood circulation, promotes the absorption of aseptic inflammation.Conventional warming needle moxibustion, moxibustion box hang shortage of heat when the moxibustion therapy such as moxibustion are burnt, being heated is limited in scope.Just has there is moxa roll after-flame during warmth sensation in warming needle moxibustion patient, and when moxibustion box hangs moxibustion, heat is relatively big, but hot feeling easily occurs, and the deficiency of holding time of hotness, moxibustion treatment scope is the most fixing.

LEIHUO moxibustion is the outstanding moxibustion therapy of a kind of big moxibustion amount, it is with other moxibustion therapy differences: (1) heat leak is good: during the burning of moxibustion bar, temperature is up to 240 degree, the rapid Transdermal absorption of heat during moxibustion treatment, patient is within the several seconds and can experience heat leak to subcutaneous tissue even deep tissue, and the heat rapid diffusion to adjacent parts occurs in some patients；(2) characteristic manipulation: hold that the right hand row of moxibustion tool sweeps scattered, convolution, passeris montani saturati such as pecks at the maneuver, left hand simultaneously painful area row draw peppery formula, point, by, the maneuver such as rub, to promote the improvement of pain；(3) moxibustion treatment scope is the most flexible: this moxibustion therapy flexible operation, and mobility Therapeutic Method makes it be applicable to the treatment of whole body most tissues.The most in all parts of the country all at the clinical position carrying out LEIHUO moxibustion treatment chronic soft tissue injuries.But, LEIHUO moxibustion therapeutic process there is also some problems: (1) heat can not preferably permeate；(2) depend merely on medicinal moxa roll and can not be effectively improved local pain；(3) during left hand manipulation, existence causes the probability of skin injury；(4) Transdermal absorption after medicine burns in LEIHUO moxibustion medicinal moxa roll is not enough.

Summary of the invention

It is an object of the invention to provide a kind of moxibustion cream Traditional Chinese medicine compound composition assisting LEIHUO moxibustion moxibustion treatment and preparation method thereof, the most subcutaneously organize with supplemental heat and deep tissue infiltration, promote the Transdermal absorption of medicine, thus it is pain caused to improve soft tissue injury.

The theory origin of the present invention and clinical practice: this prescription adds on the basis of fourth osmanthus dissipates has used the Chinese medicine Radix Lamiophlomidis Rotatae that traumatology is conventional to form.Fourth osmanthus sheds from " surgery passes firewood collection ", and medicine consists of Flos Caryophylli, Cortex Cinnamomi, its " in hindering cream, the magical effect of use is also ".Fourth osmanthus dissipates the conventional external preparation for treating traumatology soft tissue lesions, has dispersing cold for relieving pain, the effect of promoting the flow of QI-blood by warming the meridian.Its flavour of a drug fragrance, penetration is strong, and Flos Caryophylli acrid in the mouth warm in nature enters kidney channel, can temperature cold expelling wet, promoting the circulation of QI to relieve pain." Japan hanako materia medica " points out that it " can treat kidney qi, tonifying YANG, warm waist knee joint ".Main containing Oleum Caryophylli, syringopicroside etc., it is possible to expansion blood vessel, improve microcirculation, there is obvious analgesic activity.There is the effect promoting Drug Percutaneous Absorption simultaneously.Cortex Cinnamomi: acrid in the mouth warm in nature, enters kidney,spleen,liver warp.Can promoting the flow of QI-blood by warming the meridian, dispersing cold for relieving pain.Its effective ingredient is cinnamic aldehyde etc., has antiinflammatory, analgesia, sedation.

Radix Lamiophlomidis Rotatae: the Tibet medicine lamivphlomis root clinical practice history of existing more than 1000 year, the book will such as the famous Tibetan medicine classical works Four-Volume Medical Code, " Jingzhubencao ", " moon king's medicine treasure " is all described in detail: " Radix Lamiophlomidis Rotatae; mend marrow flows yellow fluid after controlling edema ".Its property is flat, sweet-bitter flavor, has the effect of promoting blood circulation and hemostasis, wind-expelling pain-stopping, is used for treating traumatic injury, rheumatic arthralgia etc..Effective ingredient is flavonoid, iridoid glycosides, phenethyl alcohol glycoside compounds, and chronic pain including, neuropathic pain and bone pain have stronger analgesic activity.

The technical solution realizing the object of the invention is: a kind of Traditional Chinese medicine compound composition assisting LEIHUO moxibustion moxibustion treatment, is made up of the crude drug of following weight portion: Flos Caryophylli 1 ~ 3 part, Cortex Cinnamomi 1 ~ 3 part, Radix Lamiophlomidis Rotatae 1 ~ 3 part.

Preferably, it is made up of the crude drug of following weight portion: Flos Caryophylli 1 part, Cortex Cinnamomi 1 part, Radix Lamiophlomidis Rotatae 1 part.

The preparation method of a kind of Traditional Chinese medicine compound composition such as described auxiliary LEIHUO moxibustion moxibustion treatment, it is characterised in that step is as follows:

Step 1, takes Flos Caryophylli and Cortex Cinnamomi adds 10 times amount water, uses the way of distillation to extract volatile oil, is not further added by volatile oil, collects volatile oil standby, and the aqueous solution after distillation filters, and collects Flos Caryophylli and Cortex Cinnamomi filtrate；

Step 2, Radix Lamiophlomidis Rotatae boiling secondary, each amount of water is more than 2 times of Radix Lamiophlomidis Rotatae crude drug, and decocting time is more than 1 hour, merges twice decoction liquor and filters, and collects Radix Lamiophlomidis Rotatae filtrate；

Step 3, merges Flos Caryophylli and the Cortex Cinnamomi filtrate of step 1 gained with the Radix Lamiophlomidis Rotatae filtrate of step 2 gained, is concentrated into the principal agent fluid extract that density is 1.1g/mL ~ 1.5g/mL；

Step 4, volatile oil step 1 produced and step 3 gained principal agent fluid extract add adjuvant mix homogeneously, makes gel or ointment.

Preferably, described in step 2, each amount of water is 5 ~ 8 times of Radix Lamiophlomidis Rotatae crude drug, and decocting time is 1 ~ 3 hour.

Preferably, the density of principal agent fluid extract described in step 3 is 1.2g/mL.

Further, gel described in step 4 is made up of the raw material of following mass percent: the principal agent fluid extract of 12% and volatile oil, 1 ~ 1.5% carbomer CP-940 adds 60% purified water swelling 24 hours, add 5% ethanol, 5% PEG400,5% propylene glycol, 5% glycerol, 0.1% ethylparaben, stir, add 2 ~ 6% triethanolamine, add purified water to 100%, stir, obtain water-soluable gel.

Further, ointment described in step 4 is made up of the raw material of following mass percent: the principal agent fluid extract of 15% and volatile oil, 10% stearic acid, 3.5% glyceryl monostearate, 8% liquid paraffin, 5% white vaseline, 0.5-1% triethanolamine, 15% propylene glycol, 10% glycerol, surplus is purified water；

First by the stearic acid of oil phase, glyceryl monostearate, liquid paraffin and white vaseline in 80 DEG C of heating and melting, again the triethanolamine of aqueous phase, propylene glycol, glycerol and purified water are preheated to 80 DEG C, oil phase is slowly added in aqueous phase, stirring while adding, heating is stopped after fully emulsified, stir to adding volatile oil when 50 DEG C, continue to stir to room temperature, prepare emulsifiable paste.

Compared with prior art, its remarkable advantage is the present invention: (1) supplemental heat is the most subcutaneously organized and deep tissue infiltration；(2) Drug Percutaneous Absorption in auxiliary LEIHUO moxibustion medicinal moxa roll；(3) have and improve the effect that soft tissue injury is pain caused；(4) there is lubrication, during left hand manipulation can be reduced, cause the probability of skin injury.

Detailed description of the invention

1, prescription of the present invention composition is provided, including composition and ratio range

The present invention assists the Traditional Chinese medicine compound composition of LEIHUO moxibustion moxibustion treatment, is made up of the crude drug of following weight portion: Flos Caryophylli 1 ~ 3 part, Cortex Cinnamomi 1 ~ 3 part, Radix Lamiophlomidis Rotatae 1 ~ 3 part.

In a preferred embodiment of the invention, the component of said medicine composition and proportioning are by the side's of tearing open experiment, and with drug effect as index, best composition proportioning is: Flos Caryophylli 1 part, Cortex Cinnamomi 1 part, Radix Lamiophlomidis Rotatae 1 part.

2, the preparation technology of this Chinese medicine

Said medicine preparation can be to include that the dosage form that described flavour of a drug form is exterior-applied formulation, including gel, ointment.

The preparation method step of said medicine is as follows:

Step 1, takes Flos Caryophylli and Cortex Cinnamomi adds 10 times amount water, uses the way of distillation to extract volatile oil, is not further added by volatile oil, collects volatile oil standby, and the aqueous solution after distillation filters, and collects Flos Caryophylli and Cortex Cinnamomi filtrate；

Step 2, Radix Lamiophlomidis Rotatae boiling secondary, each amount of water is more than 2 times of Radix Lamiophlomidis Rotatae crude drug, and preferably 5 ~ 8 times, decocting time is more than 1 hour, preferably 1 ~ 3 hour, merges twice decoction liquor and filters, and collects Radix Lamiophlomidis Rotatae filtrate；

Step 3, merges Flos Caryophylli and the Cortex Cinnamomi filtrate of step 1 gained with the Radix Lamiophlomidis Rotatae filtrate of step 2 gained, is concentrated into the principal agent fluid extract that density is 1.1g/mL ~ 1.5g/mL, preferably 1.2g/mL；

Step 4, volatile oil step 1 produced and step 3 gained principal agent fluid extract add adjuvant mix homogeneously, make gel or ointment:

Described gel is made up of the raw material of following mass percent: the principal agent fluid extract of 12% and volatile oil, 1 ~ 1.5% carbomer CP-940 adds 60% purified water swelling 24 hours, add 5% ethanol, 5% PEG400,5% propylene glycol, 5% glycerol, 0.1% ethylparaben, stir, add 2 ~ 6% triethanolamine, addition purified water, to 100%, stirs, obtains water-soluable gel.

Described ointment is made up of the raw material of following mass percent: the principal agent fluid extract of 15% and volatile oil, 10% stearic acid, 3.5% glyceryl monostearate, 8% liquid paraffin, 5% white vaseline, 0.5-1% triethanolamine, 15% propylene glycol, 10% glycerol, and surplus is purified water；First by the stearic acid of oil phase, glyceryl monostearate, liquid paraffin and white vaseline in 80 DEG C of heating and melting, again the triethanolamine of aqueous phase, propylene glycol, glycerol and purified water are preheated to 80 DEG C, oil phase is slowly added in aqueous phase, stirring while adding, heating is stopped after fully emulsified, stir to adding volatile oil when 50 DEG C, continue to stir to room temperature, prepare emulsifiable paste.Above-mentioned steps is routine operation, and the dosage form needed for difference, preparation technology can change, but is preparation common process, describes in detail the most one by one.Such as when preparing gel, add the adjuvants such as carbomer (CP-940).When preparing ointment, add the adjuvants such as glyceryl monostearate.

In the above-described embodiment, the design of the design parameter of preparation technology route is the character according to different Chinese crude drugs and pharmacological action difference, and the selection process determined with screening by analysis, if the volatile oil in Flos Caryophylli and Cortex Cinnamomi is effective ingredient, it is heated volatile, so individually extracting volatile oil；The technical conditions of soak by water are with paste-forming rate as index, determine by orthogonal test.Preparations shaping technique is investigated with character, sophistication, pH, viscosity, stretchability, stability, drug loading etc. for index and is determined.

3, the medical usage of this Chinese medicine

The chronic soft tissue injuries that this Chinese medicine causes for a variety of causes, such as disease about spine (cervical spondylosis, scapulohumeral periarthritis, lumbar muscle strain, prolapse of lumbar intervertebral disc) and extremity joint disease (knee joint osseous arthritis, rheumatoid arthritis, rheumatic arthritis, articular sprain, fracture surgery) etc..Deficiency syndrome, " injury of tendon and muscle " of cold syndrome, " numbness is sick " etc. are belonged to for the traditional Chinese medical science.This Chinese medicine can be effectively improved damage location pain, extends the time of pain relief, reduces the frequency of recurrence, alleviates the degree of recurrence.

Embodiment 1

The present embodiment assists the Traditional Chinese medicine compound composition of LEIHUO moxibustion moxibustion treatment, is made up of the crude drug of following weight portion: Flos Caryophylli 1 part, Cortex Cinnamomi 1 part, Radix Lamiophlomidis Rotatae 1 part.

The concrete preparation technology of the Traditional Chinese medicine compound composition gel of auxiliary LEIHUO moxibustion moxibustion treatment is:

(1) Flos Caryophylli and Cortex Cinnamomi extract volatile oil: take Flos Caryophylli and Cortex Cinnamomi adds 10 times amount water, soak 1 hour, use the way of distillation to extract volatile oil, are not further added by volatile oil, collect volatile oil, standby；Decocting liquid after distillation filters, and the another device of filtrate is collected.

(2) taking Radix Lamiophlomidis Rotatae boiling secondary, add 5 times amount water, decoct 1 hour every time, merge secondary decocting liquid, filter, filtrate merges with (1) decocting liquid, is concentrated into the fluid extract that relative density is 1.20.

(3) this gel is made up of the raw material of following mass percent: the principal agent fluid extract of 12% and volatile oil, 1 ~ 1.5% carbomer (CP-940) adds 60% purified water swelling 24 hours, adds 5% ethanol, 5% PEG400,5% propylene glycol, 5% glycerol, 0.1% ethylparaben, stir, add 2 ~ 6% triethanolamine, addition purified water, to 100%, stirs, obtains water-soluable gel.

Embodiment 2

The present embodiment assists the Traditional Chinese medicine compound composition of LEIHUO moxibustion moxibustion treatment, is made up of the crude drug of following weight portion: Flos Caryophylli 1 part, Cortex Cinnamomi 1 part, Radix Lamiophlomidis Rotatae 1 part.

The concrete preparation technology of the Traditional Chinese medicine compound composition ointment of auxiliary LEIHUO moxibustion moxibustion treatment is:

(1) Flos Caryophylli and Cortex Cinnamomi extract volatile oil: take Flos Caryophylli and Cortex Cinnamomi adds 10 times amount water, soak 1 hour, use the way of distillation to extract volatile oil, are not further added by volatile oil, collect volatile oil, standby；Decocting liquid after distillation filters, and the another device of filtrate is collected.

(2) taking Radix Lamiophlomidis Rotatae boiling secondary, add 5 times amount water, decoct 1 hour every time, merge secondary decocting liquid, filter, filtrate merges with (1) decocting liquid, is concentrated into the fluid extract that relative density is 1.20.

(3) this emulsifiable paste is made up of the raw material of following mass percent: the principal agent fluid extract of 15% and volatile oil, 10% stearic acid, 3.5% glyceryl monostearate, 8% liquid paraffin, 5% white vaseline, 0.5 ~ 1% triethanolamine, 15% propylene glycol, 10% glycerol, surplus is purified water.First by oil phase (stearic acid, glyceryl monostearate, liquid paraffin and white vaseline) in 80 DEG C of heating and melting, again aqueous phase (triethanolamine, propylene glycol, glycerol and purified water) is preheated to 80 DEG C, oil phase is slowly added in aqueous phase, stirring while adding, heating is stopped after fully emulsified, stir to adding volatile oil when 50 DEG C, continue to stir to room temperature, prepare emulsifiable paste.

Embodiment 3

The present embodiment assists the Traditional Chinese medicine compound composition of LEIHUO moxibustion moxibustion treatment, is made up of the crude drug of following weight portion: Flos Caryophylli 1 part, Cortex Cinnamomi 3 parts, Radix Lamiophlomidis Rotatae 3 parts.

The concrete preparation technology of the Traditional Chinese medicine compound composition gel of auxiliary LEIHUO moxibustion moxibustion treatment is:

(1) Flos Caryophylli and Cortex Cinnamomi extract volatile oil: take Flos Caryophylli and Cortex Cinnamomi adds 10 times amount water, soak 1 hour, use the way of distillation to extract volatile oil, are not further added by volatile oil, collect volatile oil, standby；Decocting liquid after distillation filters, and the another device of filtrate is collected.

(2) taking Radix Lamiophlomidis Rotatae boiling secondary, add 2 times amount water, decoct 1 hour every time, merge secondary decocting liquid, filter, filtrate merges with (1) decocting liquid, is concentrated into the fluid extract that relative density is 1.10.

(3) this gel is made up of the raw material of following mass percent: the principal agent fluid extract of 12% and volatile oil, 1 ~ 1.5% carbomer (CP-940) adds 60% purified water swelling 24 hours, adds 5% ethanol, 5% PEG400,5% propylene glycol, 5% glycerol, 0.1% ethylparaben, stir, add 2 ~ 6% triethanolamine, addition purified water, to 100%, stirs, obtains water-soluable gel.

Embodiment 4

The present embodiment assists the Traditional Chinese medicine compound composition of LEIHUO moxibustion moxibustion treatment, is made up of the crude drug of following weight portion: Flos Caryophylli 2 parts, Cortex Cinnamomi 1 part, Radix Lamiophlomidis Rotatae 1 part.

The concrete preparation technology of the Traditional Chinese medicine compound composition ointment of auxiliary LEIHUO moxibustion moxibustion treatment is:

(1) Flos Caryophylli and Cortex Cinnamomi extract volatile oil: take Flos Caryophylli and Cortex Cinnamomi adds 10 times amount water, soak 1 hour, use the way of distillation to extract volatile oil, are not further added by volatile oil, collect volatile oil, standby；Decocting liquid after distillation filters, and the another device of filtrate is collected.

(2) taking Radix Lamiophlomidis Rotatae boiling secondary, add 5 times amount water, decoct 1.5 hours every time, merge secondary decocting liquid, filter, filtrate merges with (1) decocting liquid, is concentrated into the fluid extract that relative density is 1.20.

(3) this emulsifiable paste is made up of the raw material of following mass percent: the principal agent fluid extract of 15% and volatile oil, 10% stearic acid, 3.5% glyceryl monostearate, 8% liquid paraffin, 5% white vaseline, 0.5-1% triethanolamine, 15% propylene glycol, 10% glycerol, surplus is purified water.First by oil phase (stearic acid, glyceryl monostearate, liquid paraffin and white vaseline) in 80 DEG C of heating and melting, again aqueous phase (triethanolamine, propylene glycol, glycerol and purified water) is preheated to 80 DEG C, oil phase is slowly added in aqueous phase, stirring while adding, heating is stopped after fully emulsified, stir to adding volatile oil when 50 DEG C, continue to stir to room temperature, prepare emulsifiable paste.

Embodiment 5

The present embodiment assists the Traditional Chinese medicine compound composition of LEIHUO moxibustion moxibustion treatment, is made up of the crude drug of following weight portion: Flos Caryophylli 3 parts, Cortex Cinnamomi 2 parts, Radix Lamiophlomidis Rotatae 1 part.

The concrete preparation technology of the Traditional Chinese medicine compound composition gel of auxiliary LEIHUO moxibustion moxibustion treatment is:

(1) Flos Caryophylli and Cortex Cinnamomi extract volatile oil: take Flos Caryophylli and Cortex Cinnamomi adds 10 times amount water, soak 1 hour, use the way of distillation to extract volatile oil, are not further added by volatile oil, collect volatile oil, standby；Decocting liquid after distillation filters, and the another device of filtrate is collected.

(2) taking Radix Lamiophlomidis Rotatae boiling secondary, add 6 times amount water, decoct 2 hours every time, merge secondary decocting liquid, filter, filtrate merges with (1) decocting liquid, is concentrated into the fluid extract that relative density is 1.30.

(3) this gel is made up of the raw material of following mass percent: the principal agent fluid extract of 12% and volatile oil, 1-1.5% carbomer (CP-940) adds 60% purified water swelling 24 hours, adds 5% ethanol, 5% PEG400,5% propylene glycol, 5% glycerol, 0.1% ethylparaben, stir, add 2-6% triethanolamine, addition purified water, to 100%, stirs, obtains water-soluable gel.

Embodiment 6

The present embodiment assists the Traditional Chinese medicine compound composition of LEIHUO moxibustion moxibustion treatment, is made up of the crude drug of following weight portion: Flos Caryophylli 3 parts, Cortex Cinnamomi 2 parts, Radix Lamiophlomidis Rotatae 2 parts.

The concrete preparation technology of the Traditional Chinese medicine compound composition ointment of auxiliary LEIHUO moxibustion moxibustion treatment is:

(1) Flos Caryophylli and Cortex Cinnamomi extract volatile oil: take Flos Caryophylli and Cortex Cinnamomi adds 10 times amount water, soak 1 hour, use the way of distillation to extract volatile oil, are not further added by volatile oil, collect volatile oil, standby；Decocting liquid after distillation filters, and the another device of filtrate is collected.

(2) taking Radix Lamiophlomidis Rotatae boiling secondary, add 8 times amount water, decoct 3 hours every time, merge secondary decocting liquid, filter, filtrate merges with (1) decocting liquid, is concentrated into the fluid extract that relative density is 1.50.

(3) this emulsifiable paste is made up of the raw material of following mass percent: the principal agent fluid extract of 15% and volatile oil, 10% stearic acid, 3.5% glyceryl monostearate, 8% liquid paraffin, 5% white vaseline, 0.5-1% triethanolamine, 15% propylene glycol, 10% glycerol, surplus is purified water.First by oil phase (stearic acid, glyceryl monostearate, liquid paraffin and white vaseline) in 80 DEG C of heating and melting, again aqueous phase (triethanolamine, propylene glycol, glycerol and purified water) is preheated to 80 DEG C, oil phase is slowly added in aqueous phase, stirring while adding, heating is stopped after fully emulsified, stir to adding volatile oil when 50 DEG C, continue to stir to room temperature, prepare emulsifiable paste.

Traditional Chinese medicine compound composition according to embodiment 1 ~ 6 prepared auxiliary LEIHUO moxibustion moxibustion treatment and the relation (include providing animal or clinical testing data, and analyze the effect of medicine from tcm theory) treating disease.

(1) clinical testing data

We find in preclinical research: the 1. feature of LEIHUO moxibustion cream: analgesic effect；Heat Transdermal absorption during promotion moxibustion treatment；Drug Percutaneous Absorption in medicinal moxa roll during promotion moxibustion treatment；Reduce skin injury during manipulation.2. observation of curative effect: coordinate the caused chronic soft tissue injurieies such as LEIHUO moxibustion cream treatment cervical spondylosis, scapulohumeral periarthritis, knee joint osseous arthritis in LEIHUO moxibustion operating process, painful area is fixed, palpation tenderness is obvious, and in local soft tissue, the situation such as the accessible grains of sand, tuberosity or streak thing is especially suitable.Contribute to improving pain and the moving obstacle that soft tissue injury causes further.3. in carrying out " LEIHUO moxibustion cream is on LEIHUO moxibustion treatment KOA moxibustion treatment area skin impact and therapeutic evaluation " scientific research, the patient 15 examples having met inclusive criteria treats, moxibustion cream is used during finding LEIHUO moxibustion moxibustion treatment, the rapid infiltration that when medicinal moxa roll burns, heat is subcutaneously organized can be promoted, patient is more easy to be there is the diathermanous sense in moxibustion position or expands hotness, pain is improved faster, and the persistent period course for the treatment of is longer.

(2) effect of medicine is analyzed from tcm theory

Fourth osmanthus dissipates Clinical practice record and is found in " face card one must record ": " Flos Caryophylli, each 50 grams of Cortex Cinnamomi grind to the powder altogether, are added on plaster, paste affected part after warming, can dispelling cold by warming the meridian, pain relieving of detoxifying, treat carbuncle furunculosis.”." China traditional Chinese medical science secret recipe complete works of " records: " Flos Caryophylli, each equal portions of Cortex Cinnamomi, grind into powder to be added on plaster and apply ointment or plaster, can expelling wind and cold, temperature three-way meridian, treat YIN syndrome abscess pain "." Chinese traumatology " Empirical formula also has this type of to record: " Flos Caryophylli, Cortex Cinnamomi add medicine to each equal portions, grind to the powder and add on plaster, can expelling wind and cold, promoting the flow of QI in the collateral by warming the meridian, to control YIN syndrome abscess pain ".In above books, fourth osmanthus dissipates external side's proportion compatibility and is 1:1.

Flos Caryophylli property and flavor of peppery and warm, returns spleen, stomach, lung, kidney channel, has warming middle-JIAO to send down the adverse QI, dispersing cold for relieving pain, warming the kidney to activate YANG effect.Cortex Cinnamomi nature and flavor are pungent, sweet, the hottest, return kidney, spleen, the heart, Liver Channel, and it is supporing yang that function mends fire, dispersing cold for relieving pain, warming the meridian and promoting blood circulation.Flos Caryophylli, Cortex Cinnamomi belong to warming the interior medicine together.Radix Lamiophlomidis Rotatae is flat, sweet-bitter flavor, has the effect of promoting blood circulation and hemostasis, wind-expelling pain-stopping.Pain caused by chronic soft tissue injuries belongs to the traditional Chinese medical science " injury of tendon and muscle ", " numbness is sick " category clinically, pathogenesis is that wind-cold damp pathogen blocks meridians, wound or strain cause muscle arteries and veins impaired, QI-blood circulation is the most smooth, stagnation of QI and blood may bring about pain, or because of caused by liver and kidney deficiency, muscle arteries and veins loses supports, Rong Ze pain, does not belongs to cold syndrome, blood stasis syndrome, deficiency syndrome more.Therefore answer Wen Tongyu to invigorate blood circulation in treatment and lay equal stress on, therefore select Flos Caryophylli, Cortex Cinnamomi, Radix Lamiophlomidis Rotatae three taste medicine compatibility.

(3) this Chinese medicine and the relation treating disease

Previously correlational study is as follows:

1. fourth osmanthus dissipates

Take fourth osmanthus scattered (Flos Caryophylli, each equal portions of Cortex Cinnamomi are ground into powder) and put into SHEXIANG ZHUANGGU GAO center, external application affected part, the treatment injury of tendon and muscle, Flos Caryophylli, the warm middle dredging collateral of Cortex Cinnamomi warming the interior cold expelling, the dehumidifying of SHEXIANG ZHUANGGU GAO Radix Saposhnikoviae, promoting blood circulation and stopping pain, maneuver is coordinated to rub with promoting blood circulation to restore menstrual flow, relieving spasm to stop pain, three methods are share, and contribute to disappearing of local inflammation and edema, therefore can receive the effect of relieving spasm to stop pain, relaxing muscles and tendons and activating QI and blood in the collateral.By Flos Caryophylli, Cortex Cinnamomi and Olibanum, Myrrha, the same use of Sanguis Draxonis, name adds taste fourth osmanthus and dissipates, for carbuncle of yin nature from the beginning of, congealing cold with blood stasis person, and traumatic injury, stop stasis of blood network epigenesist.

2. fourth osmanthus dissipates plus-minus

Take fourth osmanthus to dissipate and Radix Aconiti Lateralis Preparata phase 5, spread on shen shu, to treat lumbago due to cold-damp, with Scorpio, Scolopendra phase 5, treatment wind and cold arthromyodynia etc..

3. Radix Lamiophlomidis Rotatae

Treating prolapse of lumbar intervertebral disc with Radix Lamiophlomidis Rotatae, total effective rate reaches 91.69%.Experiment proves that Radix Lamiophlomidis Rotatae extractum can significantly improve abdominal cavity macrophage phagocytosis, macrophage phagocytic index, E-garland formation rate and esterase dyeing positive rate, effectively suppress to cause the synthesis of the main matter prostaglandin of pain and inflammation, and can promote that local organization blood circulation, releasing venous return are obstructed, edema is made to alleviate, inflammatory resolution, alleviates the compressing to nerve root.Using local soft tissue damage after Radix Lamiophlomidis Rotatae treatment fracture, result shows to have in terms of pain relieving and detumescence original controls furuncle effect, and in experimentation, after medication, about 2 hours pain starts to alleviate, and pain is substantially alleviated after 4 hours, and after taking continuously 3-7 days, pain disappears substantially；And after taking medicine 24 hours, swelling starts to disappear, and can substantially restore to the original state after 5 days.

Claims (7)

1. the moxibustion cream Traditional Chinese medicine compound composition assisting LEIHUO moxibustion moxibustion treatment, it is characterised in that be made up of the crude drug of following weight portion: Flos Caryophylli 1 ~ 3 part, Cortex Cinnamomi 1 ~ 3 part, Radix Lamiophlomidis Rotatae 1 ~ 3 part.

The moxibustion cream Traditional Chinese medicine compound composition of auxiliary LEIHUO moxibustion moxibustion treatment the most according to claim 1, it is characterised in that be made up of the crude drug of following weight portion: Flos Caryophylli 1 part, Cortex Cinnamomi 1 part, Radix Lamiophlomidis Rotatae 1 part.

3. the preparation method of the moxibustion cream Traditional Chinese medicine compound composition of an auxiliary LEIHUO moxibustion moxibustion treatment as claimed in claim 1, it is characterised in that step is as follows:

Step 1, takes Flos Caryophylli and Cortex Cinnamomi adds 10 times amount water, uses the way of distillation to extract volatile oil, is not further added by volatile oil, collects volatile oil standby, and the aqueous solution after distillation filters, and collects Flos Caryophylli and Cortex Cinnamomi filtrate；

Step 2, Radix Lamiophlomidis Rotatae boiling secondary, each amount of water is more than 2 times of Radix Lamiophlomidis Rotatae crude drug, and decocting time is more than 1 hour, merges twice decoction liquor and filters, and collects Radix Lamiophlomidis Rotatae filtrate；

Step 3, merges Flos Caryophylli and the Cortex Cinnamomi filtrate of step 1 gained with the Radix Lamiophlomidis Rotatae filtrate of step 2 gained, is concentrated into the principal agent fluid extract that density is 1.1g/mL ~ 1.5g/mL；

Step 4, volatile oil step 1 produced and step 3 gained principal agent fluid extract add adjuvant mix homogeneously, makes gel or ointment.

The preparation method of the moxibustion cream Traditional Chinese medicine compound composition of auxiliary LEIHUO moxibustion moxibustion treatment the most according to claim 3, it is characterised in that described in step 2, each amount of water is 5 ~ 8 times of Radix Lamiophlomidis Rotatae crude drug, and decocting time is 1 ~ 3 hour.

The preparation method of the moxibustion cream Traditional Chinese medicine compound composition of auxiliary LEIHUO moxibustion moxibustion treatment the most according to claim 3, it is characterised in that the density of principal agent fluid extract described in step 3 is 1.2g/mL.

The preparation method of the moxibustion cream Traditional Chinese medicine compound composition of auxiliary LEIHUO moxibustion moxibustion treatment the most according to claim 3, it is characterized in that, gel described in step 4 is made up of the raw material of following mass percent: the principal agent fluid extract of 12% and volatile oil, 1 ~ 1.5% carbomer CP-940 adds 60% purified water swelling 24 hours, add 5% ethanol, 5% PEG400,5% propylene glycol, 5% glycerol, 0.1% ethylparaben, stir, add 2 ~ 6% triethanolamine, add purified water to 100%, stir, obtain water-soluable gel.

The preparation method of the moxibustion cream Traditional Chinese medicine compound composition of auxiliary LEIHUO moxibustion moxibustion treatment the most according to claim 3, it is characterized in that, ointment described in step 4 is made up of the raw material of following mass percent: the principal agent fluid extract of 15% and volatile oil, 10% stearic acid, 3.5% glyceryl monostearate, 8% liquid paraffin, 5% white vaseline, 0.5-1% triethanolamine, 15% propylene glycol, 10% glycerol, surplus is purified water；

First by the stearic acid of oil phase, glyceryl monostearate, liquid paraffin and white vaseline in 80 DEG C of heating and melting, again the triethanolamine of aqueous phase, propylene glycol, glycerol and purified water are preheated to 80 DEG C, oil phase is slowly added in aqueous phase, stirring while adding, heating is stopped after fully emulsified, stir to adding volatile oil when 50 DEG C, continue to stir to room temperature, prepare emulsifiable paste.