CN105919550A - Method for positioning and measuring eccentricity of central foveae of maculae on basis of optical coherence tomography technologies - Google Patents
Method for positioning and measuring eccentricity of central foveae of maculae on basis of optical coherence tomography technologies Download PDFInfo
- Publication number
- CN105919550A CN105919550A CN201610431498.6A CN201610431498A CN105919550A CN 105919550 A CN105919550 A CN 105919550A CN 201610431498 A CN201610431498 A CN 201610431498A CN 105919550 A CN105919550 A CN 105919550A
- Authority
- CN
- China
- Prior art keywords
- macula
- central fovea
- coherence tomography
- image
- central
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/02—Subjective types, i.e. testing apparatus requiring the active assistance of the patient
Abstract
The invention discloses a method for positioning and measuring the eccentricity of central foveae of maculae on the basis of optical coherence tomography technologies. The method includes acquiring the accurate locations of the central foveae of the maculae by means of optical coherence tomography; computing the relative distances from the central foveae of the maculae to known fixation points which are optical axis locations. The method has the advantages that the eccentricity can be quickly and accurately measured by the aid of the method, the resolution can reach 3 micrometers, tiny eccentric fixation can be identified, and guidance can be provided for clinical treatment and follow-up visit.
Description
Technical field
The present invention relates to medical science and optoelectronic areas, it is specifically related to the method that offset is measured in the central fovea of macula location of a kind of optically-based coherence tomography technique.
Background technology
The sharpest position of normal eye's vision is central fovea of macula.General human eye, with central fovea of macula as blinkpunkt, obtains image the most clearly with this.Such nature of fixation is referred to as central fixation.But in eccentric fixation children with amblyopia, owing to the effective stimulus during visual development is not enough, thus cause one side or bilateral to correct defects of vision less than normal child of the same age.The illness rate of the amblyopia in population of adolescent is 2%-4%.The amblyopia also current modal eye disease of children, and eccentric fixation therein has a strong impact on eyesight, reduces the quality of life of people.Wherein, so-called eccentric fixation refers to that human eye fixation point deviates to a certain degree (clinically with 1 ° as line of demarcation, be specifically shown in hereafter) with the central fovea of macula (the sharpest position) of human eye.The nature of fixation of the children with amblyopia according to human eye has important directive significance and prognosis prediction effect to its therapeutic modality and prognosis.In view of the Best Times of amblyopia treatment is 4-6 one full year of life, measure offset as early as possible and accurately particularly significant.
At present, conventional clinically offset measuring method is surveillance mirror inspection.In common ophthalmoscope, add black star sighting target, advise patient to watch black star sighting target attentively, the central fovea of macula reflective spot position (as shown in Figure 5) observed according to examiner, it can be determined that obtain the relative position of patient's blinkpunkt and central fovea of macula.Clinically, will be located in the nature of fixation within concentric circles 1 ° and be referred to as central fixation, the referred to as eccentric fixation beyond 1 °.Wherein watching attentively centered by A in Fig. 5, B is eccentric fixation.First concentric circles is 1 °.
But in clinical practice, owing to this inspection method is coarse, being suitable for the eccentric judgement of wide-angle, low-angle bias is easily failed to pinpoint a disease in diagnosis.And checking that result is relevant to operating distance, in checking process, the change of operating distance can cause the movement of reflective spot position, thus affects judgement.It addition, micro-visual field meter can also be used for the measurement of nature of fixation.Micro-perimetric result the most rougher (such as Fig. 2), lightsensitivity distribution map acquisition time is longer simultaneously, and simplest pattern is about 4 minutes.Children with amblyopia coordinates poor, it is impossible to the micro-perimetric measurement of long-time cooperation.
Summary of the invention
In order to solve the deficiencies in the prior art, the method that offset is measured in the central fovea of macula location providing a kind of optically-based coherence tomography technique of the present invention.
The technical solution that the present invention uses is: the method that offset is measured in the central fovea of macula location of a kind of optically-based coherence tomography technique, and described measuring method comprises the following steps:
(1) three-dimensional retina faultage image is obtained by Optical coherence tomography (OCT): in the coaxial light path of OCT scan light path, increase by an E word watch sighting target and supplementary mirror attentively, peephole is placed before sighting target, to guarantee that watching attentively of human eye is watched attentively on sighting target at E word, sighting target before experimenter's fixating eye, after completing the most complete motion of twinkling, shooting retina faultage image N frame with horizontal 3D-raster pattern, position, N/2 two field picture horizontal middle is then blinkpunkt position；
(2) according to the acquisition parameters of OCT, after correcting the degree of depth, length and axis oculi, it is calculated the absolute growth L at every two field picture interval, and length D that each pixel of image abscissa is corresponding, then calculates horizontal range and the vertical range of central fovea of macula deviation blinkpunkt.
The described computational methods calculating horizontal range and vertical range that central fovea of macula deviates blinkpunkt are: choose n-th image the most obvious central fovea of macula reflective spot occur, open image, the abscissa d of the central fovea of macula reflective spot in reading image, if the horizontal pixel point of image is M altogether, central fovea of macula deviation blinkpunkt can be calculated according to below equation
Horizontal range is: (M/2-d) * D
Vertical range is: (N/2-n) * L.
Described OCT system uses wavelength to be 840nm, and with the infrared diode light source of a width of 100nm, axial resolution is 3um, and sweep speed is 120 frames/second.
Described peephole size is 3mm.
Described image is opened in MATLAB.
The invention has the beneficial effects as follows: the method invention of the central fovea of macula location measurement offset that the invention provides a kind of optically-based coherence tomography technique obtains central fovea of macula position accurately by optical coherent chromatographic imaging, known blinkpunkt is optical axis position, calculates central fovea of macula and blinkpunkt relative distance.The method can the most accurately measure offset, and resolution ratio, up to 3 μm, can identify that minor eccentricities is watched attentively, instructs with following up a case by regular visits to provide for clinical treatment.
Accompanying drawing explanation
Fig. 1 be central fovea of macula based on OCT location measure offset watch schematic diagram attentively.
Fig. 2 is the OCT schematic diagram of device for measuring central fovea of macula.
Fig. 3 is the schematic diagram of the computational methods of offset based on the present invention.
Fig. 4 is the measurement result contrast of the inventive method and conventional method.
Fig. 5 is existing offset measuring method schematic diagram.
Detailed description of the invention
In conjunction with Fig. 1, Fig. 2, Fig. 3, Fig. 4, the present invention is further described, the method that offset is measured in the central fovea of macula location of a kind of optically-based coherence tomography technique.It comprises the following steps: step one, obtains three-dimensional retina faultage image by Optical coherence tomography.The OCT system that this patent relates to uses wavelength to be 840nm, and with the infrared diode light source of a width of 100nm, axial resolution is 3um, and sweep speed is 120 frames/second.For realizing watching location attentively, the coaxial light path of OCT scan light path increases an E word and watches sighting target and supplementary mirror attentively, the peephole of size 3mm is placed before sighting target, watch attentively on E word sighting target (such as Fig. 1) with guarantee human eye, advise the sighting target before experimenter's fixating eye, after the most complete motion of twinkling, with horizontal 3D-raster pattern (square scan) shooting retina faultage image N frame (such as Fig. 3), then position, N/2 two field picture horizontal middle is then blinkpunkt position；Second step: according to the acquisition parameters of OCT, after correcting the degree of depth, length and axis oculi, is calculated the absolute growth L at every two field picture interval, and length D that each pixel of image abscissa is corresponding；Choose n-th image that the most obvious central fovea of macula reflective spot occurs, MATLAB opens image, the abscissa d of the central fovea of macula reflective spot in reading image.Assume that the horizontal pixel point of image, altogether for M, can be calculated central fovea of macula deviation blinkpunkt (such as Fig. 3) according to formula
Horizontal range is: (M/2-d) * D
Vertical range is: (N/2-n) * L
Wherein the sign of result of calculation is the central fovea of macula deviation top of blinkpunkt, lower section, nasal side and temporo side, and, scan pattern other with specific reference to the eye shot and interpreting blueprints pattern may determine that.
According to above innovative approach, include 2 example infants and carried out Method validation and test.
1st example is the boy of 15 one full year of life, and medical based refraction is OD:pl=1.0, OS:+2.25D=0.2-1.Then accept through ophthalmoscope, OCT and micro-perimetry.The experimenter of the 2nd example checking included is the boy of 8 years old, OD:+0.75/-0.75*175=1.0, OS:+4.00/-1.50*5=0.5.Owing to it can not coordinate micro-perimetric data acquisition, so not obtaining this item data.Through 2 example date comprision, we are it appeared that the result uniformity of three kinds of methods, ophthalmoscope and micro-perimetric precision are at 300-436 micron, and the precision of OCT is up to 3 microns.The most Oph result can be obtained by about 1s, therefore requires minimum to the fitness of patient, and micro-perimetric result needs patient's response of about 4 minutes, because fitness requires the highest, the picking rate of OCT is fast, can complete in 8s.As shown in Figure 4, star figure is ophthalmoscope result, and cross is that result is counted in micro-visual field, and filled circles is OCT result, and black is casel result, and grey is case2 result.
The above is only the preferred embodiment of the present invention, and protection scope of the present invention is not limited merely to above-described embodiment, and all technical schemes belonged under thinking of the present invention belong to protection scope of the present invention.It should be pointed out that, for those skilled in the art, some improvements and modifications without departing from the principles of the present invention, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (5)
1. the side of offset is measured in the central fovea of macula location of an optically-based coherence tomography technique
Method, it is characterised in that described measuring method comprises the following steps:
(1) three-dimensional retina faultage image is obtained by Optical coherence tomography (OCT):
Increase by an E word in the coaxial light path of OCT scan light path and watch sighting target and supplementary mirror attentively, place before sighting target and peep
Hole, to guarantee that watching attentively of human eye is watched attentively on sighting target at E word, the sighting target before experimenter's fixating eye, complete once
After complete motion of twinkling, shoot retina faultage image N frame, N/2 with horizontal 3D-raster pattern
Position, two field picture horizontal middle is then blinkpunkt position；
(2) according to the acquisition parameters of OCT, after correcting the degree of depth, length and axis oculi, it is calculated every frame figure
As the absolute growth L at interval, and length D that each pixel of image abscissa is corresponding, then calculate macula lutea
The horizontal range of central fovea deviation blinkpunkt and vertical range.
The central fovea of macula of a kind of optically-based coherence tomography technique the most according to claim 1
The method of offset is measured in location, it is characterised in that the described water calculating central fovea of macula deviation blinkpunkt
The computational methods of flat distance and vertical range are: choose n-th that the most obvious central fovea of macula reflective spot occur
Image, opens image, reads the abscissa d of central fovea of macula reflective spot in image, if the level of image
Pixel is M altogether, can be calculated central fovea of macula deviation blinkpunkt according to below equation
Horizontal range is: (M/2-d) * D
Vertical range is: (N/2-n) * L.
The central fovea of macula of a kind of optically-based coherence tomography technique the most according to claim 1
The method of offset is measured in location, it is characterised in that described OCT system uses wavelength to be 840nm, band
The infrared diode light source of a width of 100nm, axial resolution is 3um, and sweep speed is 120 frames/second.
The central fovea of macula of a kind of optically-based coherence tomography technique the most according to claim 1
The method of offset is measured in location, it is characterised in that described peephole size is 3mm.
The central fovea of macula of a kind of optically-based coherence tomography technique the most according to claim 2
The method of offset is measured in location, it is characterised in that described image is opened in MATLAB.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610431498.6A CN105919550B (en) | 2016-06-16 | 2016-06-16 | A kind of method of the central fovea of macula positioning measurement offset based on Optical Coherence Tomography Imaging Technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610431498.6A CN105919550B (en) | 2016-06-16 | 2016-06-16 | A kind of method of the central fovea of macula positioning measurement offset based on Optical Coherence Tomography Imaging Technology |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105919550A true CN105919550A (en) | 2016-09-07 |
| CN105919550B CN105919550B (en) | 2017-09-29 |
Family
ID=56831505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610431498.6A Active CN105919550B (en) | 2016-06-16 | 2016-06-16 | A kind of method of the central fovea of macula positioning measurement offset based on Optical Coherence Tomography Imaging Technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105919550B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110916611A (en) * | 2018-09-18 | 2020-03-27 | 株式会社拓普康 | Ophthalmologic apparatus, control method thereof, program, and storage medium |
| CN111094940A (en) * | 2017-07-19 | 2020-05-01 | 小川宏 | Tomographic imaging apparatus |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090268162A1 (en) * | 2008-04-24 | 2009-10-29 | Carl Zeiss Meditec, Inc. | Method for finding the lateral position of the fovea in an sdoct image volume |
| CN101778593A (en) * | 2007-06-15 | 2010-07-14 | 南加州大学 | Pattern analysis of retinal maps for diagnosis of optic nerve diseases by optical coherence tomography |
| US20130148081A1 (en) * | 2010-08-24 | 2013-06-13 | Kowa Company Ltd. | Visual field examination system |
| CN104146681A (en) * | 2014-08-15 | 2014-11-19 | 深圳市斯尔顿科技有限公司 | Eye ground retina OCT image correction method |
| CN104434026A (en) * | 2014-12-17 | 2015-03-25 | 深圳市斯尔顿科技有限公司 | Method for detecting deviation of retina fixation point relative to macular central fovea |
-
2016
- 2016-06-16 CN CN201610431498.6A patent/CN105919550B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101778593A (en) * | 2007-06-15 | 2010-07-14 | 南加州大学 | Pattern analysis of retinal maps for diagnosis of optic nerve diseases by optical coherence tomography |
| US20090268162A1 (en) * | 2008-04-24 | 2009-10-29 | Carl Zeiss Meditec, Inc. | Method for finding the lateral position of the fovea in an sdoct image volume |
| US20130148081A1 (en) * | 2010-08-24 | 2013-06-13 | Kowa Company Ltd. | Visual field examination system |
| CN104146681A (en) * | 2014-08-15 | 2014-11-19 | 深圳市斯尔顿科技有限公司 | Eye ground retina OCT image correction method |
| CN104434026A (en) * | 2014-12-17 | 2015-03-25 | 深圳市斯尔顿科技有限公司 | Method for detecting deviation of retina fixation point relative to macular central fovea |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111094940A (en) * | 2017-07-19 | 2020-05-01 | 小川宏 | Tomographic imaging apparatus |
| CN111094940B (en) * | 2017-07-19 | 2022-08-16 | 小川宏 | Tomographic imaging apparatus |
| CN110916611A (en) * | 2018-09-18 | 2020-03-27 | 株式会社拓普康 | Ophthalmologic apparatus, control method thereof, program, and storage medium |
| US11547294B2 (en) | 2018-09-18 | 2023-01-10 | Topcon Corporation | Ophthalmic apparatus, controlling method thereof, and recording medium |
| US11813022B2 (en) | 2018-09-18 | 2023-11-14 | Topcon Corporation | Ophthalmic apparatus, controlling method thereof, and recording medium |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105919550B (en) | 2017-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104684458B (en) | For reliably determining the device of the bio-identification measurand of whole eyes | |
| CN102670165B (en) | Image photographing apparatus and image photographing method | |
| CN104958061B (en) | The optical fundus OCT image method of binocular stereo vision three-dimensional imaging and system thereof | |
| US10433724B2 (en) | Method and apparatus for determining the location of the ocular pivot point | |
| ES2861259T3 (en) | Eyeglass prescription method and system | |
| CN102525403B (en) | Ophthalmologic apparatus and control method therefor | |
| ES2417814T3 (en) | Apparatus and procedure to automatically determine an angle of strabismus | |
| US8491122B2 (en) | Arrangement for attaining high-precision measurements of an eye | |
| ES2904778T3 (en) | Determination of a change in the refractive error of an eye | |
| JPH09509334A (en) | Device for monitoring intraocular pressure and blood pressure | |
| WO2011040404A9 (en) | Device and method for diagnosing and/or monitoring glaucoma | |
| CN103976707A (en) | OCT (Optical Coherence Tomography) system for measuring optical path value of axis oculi and method | |
| US10420463B2 (en) | Method for determining the topography of the cornea of an eye | |
| CN104146681A (en) | Eye ground retina OCT image correction method | |
| Adnan et al. | Lens shape and refractive index distribution in type 1 diabetes | |
| CN203987986U (en) | Corneal vertex alignment system and axis oculi optical path length measuring system | |
| CN110537895A (en) | Retina detecting system based on virtual reality technology | |
| CN105919550A (en) | Method for positioning and measuring eccentricity of central foveae of maculae on basis of optical coherence tomography technologies | |
| CN101584573A (en) | Interpupillary distance, optical range measuring device | |
| De-Pablo-Gómez-de-Liaño et al. | Agreement between three optical coherence tomography devices to assess the insertion distance and thickness of horizontal rectus muscles | |
| Miller et al. | Videographic Hirschberg measurement of simulated strabismic deviations. | |
| CN103976708B (en) | Corneal vertex alignment methods and system and axis oculi optical path length measuring method and system | |
| CN101248982A (en) | Visual optics analysis system | |
| RU2767704C1 (en) | Method for diagnosing strabismus by video eye tracking | |
| KR101644489B1 (en) | Method for heterophoria measuring |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |