CN1058897C - Agentia for improving genitality and producing process thereof - Google Patents

Abstract

The present invention relates to an agentia and a preparing method for improving genitality, which overcomes the defects that the treating effect is not ideal due to not having a fixed special prescription in treating diseases by judging symptoms, and patients feel inconvenience in getting medicines for decocting tea herb according to a prescription due to the use medicines of animals and plants. The agentia of the present invention is mainly composed of ginseng, yam, fried white atractylodes rhizome, astragalus root, wolfberry fruit, radix aconiti latearlis preparata, broomrape, etc., wherein the medicines are pulverized for decoction to extract effective liquid which is used for concentration; after the concentrated effective liquid is dried to be prepared into powdered extract, the powdered extract is pressed into particles in a drying mode. The present invention can treat various types of male sterility, and has the characteristics of convenient clinical diagnosis and patient taking, easy commercial process, etc.

Description

Agentia for improving genitality and manufacture method thereof

The present invention relates to a kind of agentia for improving genitality and manufacture method thereof, particularly treat the medicine and the preparation technology thereof of male infertility.

Think male infertility at present, mostly because of due to sperm, Necrospermia, no sperm, sperm deformity, seminal fluid not liquefaction, anejaculation, sexual impotence, the premature ejaculation etc. less.The traditional Chinese medical science generally is divided into it renal deficiency type (deficiency of kidney-essence, decline of kidney-YANG, damage of kidney-YIN), spleen-deficient (deficiency of QI in middle-JIAO, hypoactivity of spleen-YANG), blood-deficiency type, blood stasis type, phlegm-damp type, liver-cold type, liver energy stagnation type, damp-heat type etc. for this disease of treatment.At above various, adopt 1. the kidney invigorating method usually respectively, prescription has shenqi pill, Bolus as a Kidney-Yin-Tonic, Yougui Wan, the kidney-Yang-Reinforcing Bolus, ZHIBAI DIHUANG WAN etc., and common drug has Radix Aconiti Lateralis Preparata.Semen Cuscutae, Cortex Cinnamomi, Actinolitum, Fructus Cnidii, Radix Morindae Officinalis, Semen Allii Tuberosi, Fructus Psoraleae, Cornu Cervi, the Radix Astragali, the Rhizoma Anemarrhenae, Cortex Phellodendri, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Corni, Radix Asparagi, Herba Cistanches, the Radix Polygoni Multiflori, Carapax Trionycis, Tong Fructus Tribuli etc., 2. drying dampness to eliminate phlegm, clearing away heat-damp and promoting diuresis method, prescription has Decoction of Gentiana for Purging the Liver-fire, Rhizoma Atractylodis Daotan Tang etc., common drug has Cortex Phellodendri (parched), Rhizoma Atractylodis (parched), Semen Coicis, Radix Cyathulae, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae, Semen Plantaginis, Radix Gentianae, Clematis kerriana Drumm. Et Craiab, Rhizoma Alismatis, Flos Lonicerae, Rhizoma Dioscoreae Septemlobae, Rhizoma Acori Graminei, Plumula Nelumbinis, Radix Scutellariae, Radix Glycyrrhizae etc.; 3. heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the strong smart method of the kidney invigorating; 4. soothing liver-QI for relieving depression, clearing away heat-damp and promoting diuresis method, prescription have XIAOYAO POWDER, the treatment of Decoction of Gentiana for Purging the Liver-fire plus-minus; 5. nourishing the heart and kidney method, common drug have Radix Rehmanniae Preparata, Radix Codonopsis, Radix Asparagi, Radix Salviae Miltiorrhizae, Poria, Fructus Schisandrae Chinensis, Radix Morindae Officinalis, Herba Epimedii, Rhizoma Curculiginis, Semen Ziziphi Spinosae (parched), Fructus Corni etc.; 6. depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, collateral dredging spermatogenesis method, common drug has Radix Bupleuri, Fructus Aurantii, Squama Manis, Fructus Liquidambaris, Pheretima (parched), Semen Persicae (parched), Flos Carthami, Radix Paeoniae Rubra, Radix Astragali Pericarpium Citri Reticulatae, Semen Cuscutae, Radix Cyathulae, Ramulus Cinnamomi.The testis patient adds Rhizoma Corydalis, Radix Osyris Wightianae etc., 7. qi and blood tonifying method, and prescription has eight delicacies Tonga flavor, often adds male Bombycis mori, Colla cornus cervi, Rhizoma Polygonati, Placenta Hominis, Fructus Lycii, Fructus Ligustri Lucidi, Semen Cuscutae, Passeris montani saturati meat powder, dog head bone meal, Herba Epimedii etc.; 8. activating blood and removing stasis Method, prescription has logical essence to fry in shallow oil (Radix Salviae Miltiorrhizae, Rhizoma Curcumae, Radix Cyathulae, Radix Bupleuri, Concha Ostreae, Radix Astragali etc.), and the reason essence methods such as (Eupolyphaga Seu Steleophaga, Radix Angelicae Sinensis, Radix Dipsaci, Rhizoma Cibotii, Radix Cyathulae, Rhizoma Curcumae, Herba Cistanches, Cornu Cervi Degelatinatums etc.) of frying in shallow oil is carried out determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.Weak point is, at first, extremely complicated because of this disease cause of disease, still can not understand the place of its cause of disease and pathogenesis fully so far, too flexible during determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs clinically, plus-minus changes also many, do not have and to be fixed with specially good effect and to become to comply with, make the clinician be difficult to accurate utilization, so it is generally undesirable to treat this sick effect clinically.Secondly, because of the medicine of selecting for use mostly is animal and plant, need the patient according to doctor's prescription according to singly making up the prescription, be equipped with and decoct into decoction more voluntarily after complete, so make it feel inconvenience deeply.

The purpose of this invention is to provide and a kind ofly can rule various types of male infertilitys effectively and for patient's agentia for improving genitality and manufacture method thereof easy to use.

For achieving the above object, of the present inventionly prolong that to succeed granule be to be made by the raw material of following weight ratio: Radix Ginseng 2.4～3, Rhizoma Dioscoreae 2～3, Rhizoma Atractylodis Macrocephalae preparata 2～3, the Radix Astragali 2～3, Fructus Lycii 3～4, Radix Aconiti Lateralis Preparata 0.4～1, Herba Cistanches 3～4, Semen Nelumbinis 3～4, Semen Cuscutae 0.6～1, Fructus Rubi 2～3, the Radix Aucklandiae 3～4, Fructus Amomi 3～4, Cortex Phellodendri 2～3, Semen Plantaginis 0.6～1, Colla Corii Asini 3～4.The preparation method of granule of the present invention is finished according to the following steps: after Radix Ginseng, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae preparata, the Radix Astragali, Fructus Lycii, Radix Aconiti Lateralis Preparata, Herba Cistanches, Semen Nelumbinis, Semen Cuscutae, Fructus Rubi, the Radix Aucklandiae, Fructus Amomi, Cortex Phellodendri, Semen Plantaginis and Colla Corii Asini cleaning, drying, pulverizing, putting into extraction pot soaked more than 50 minutes, inject steam, temperature is controlled at 110～130 ℃ and decocted 80～100 minutes, carries out dynamic extraction while decocting; Extracting solution is carried out after vacuum and low temperature concentrates, and spray drying is to make extract powder, and spray-dired temperature is 110～160 ℃; Afterwards, after being pressed into graininess, packs extract powder.

The present invention has following advantage compared to existing technology:

1. selected Radix Ginseng strongly invigorating primordial QI, invigorating the spleen to benefit the lung, calm the nerves and promote the production of body fluid, Rhizoma Dioscoreae supplementing QI and nourishing YIN, spleen reinforcing lung, Rhizoma Atractylodis Macrocephalae preparata air making-up and spleen enlivening antidiarrheal, Radix Astragali tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance, the Fructus Lycii nourishing the liver and kidney, make eye bright, Radix Aconiti Lateralis Preparata return the moon rescue contrary, to mend fire supporing yang, the Herba Cistanches reinforcing the kidney and supporting YANG, Semen Nelumbinis, Semen Cuscutae, Fructus Rubi spleen reinforcing antidiarrheal, nourishing YIN tonifying YIN, tranquilizing by nourishing the heart, supplementing the kidney to control the nocturnal, reducing urination, the Radix Aucklandiae, Fructus Amomi removing dampness circulation of qi promoting are antiabortive, Cortex Phellodendri, Semen Plantaginis clearing away heat-damp and promoting diuresis, accent liver, the Colla Corii Asini nourishing blood hemostasis.More than all medicines share the effect of the reinforcing spleen and kidney of can building together, the controlling nocturnal emission with astringent drugs that expels the heat-evil, can rule various male infertility, and curative effect is rapid, cured the thousands of examples of patient, it is existing that only to select following case be visible one spot:

Example 1: Zhu * *, man, 28 years old, do not educate in 7 years after marriage, and went to a doctor once and check, be diagnosed as few essence and full necrospermia, multi-treatment is invalid, and in here prescription on individual diagnosis in May nineteen ninety, it is red to see its complexion crow, the lip crow, pale tongue, tongue is white, appetite is general, stool day for several times, matter is soft; urine is clear, gets heavy slightly unablely late in its arteries and veins, dialectical be the unusual and necrospermia time of spermatozoon due to deficiency of spleen-YANG and kidneyYANG and the essence stasis.Control to prolong and succeed the I granule, after taking medicine 36 days, semen efamination PH (), sperm number 0.9 hundred million/ML, seminal fluid liquefying time 25 minutes, three examine in February, 1991, inform that its wife is surplus conceived February, and the cesarotomy of going is at the end of the same year given birth to a boy.

Example 2: the king * *, the man 26 years old, did not educate, and examined over 1994 in 3 years after marriage.Hope its complexion dark simple and unadorned, the light crow of lip, body of the tongue is light red, yellow and thin fur, there is the tooth seal on the limit, petechia, the bodily form is become thin, once suffered from lymphoid tuberculosis, the masturbation history arranged, the time giddy, order flower tinnitus, mouthful little hardship, dry pharynx, poor appetite, limbs fatigue, soreness of the waist and knees, night sweat, the sexual life frequency, sexual life is perspired, dribbling urination, thready and soft pulse; Semen efamination is not seen spermatozoon.Clothes prolong succeeded the I granule after 36 days, and semen efamination is normal, and its wife is conceived after February, gives birth to a girl April next year.

Example 3: Lee *, the man, 28 years old, not educate in 4 years after marriage, examine in March, 1996.Card is seen giddy, tinnitus, irritated irritability, hyperactivity of the ministerial fire is lifted during male sexuality, lift and not hard, heavily fortified point also soon, body of the tongue is light red, thready and stringy pulse, the seminal fluid check: sperm number is few, and activity ratio is low.Clothes prolong succeeded the I granule after 48 days, and semen efamination is normal, and its wife is conceived after February, and next year is given birth to a boy.

Example 4: poplar *, man, 23 years old, first chinesization, do not educate in married 2 years, the inquiry medical history was once suffered from lymphoid tuberculosis, masturbation history, dizziness, tinnitus, bitter taste, dry pharynx, limbs fatigue; dysuria, night sweat, the sexual life frequency, face is dark and gloomy simple and unadorned; the light crow of lip, and body of the tongue is light red, the little Huang of tongue; there is the tooth seal on the limit, petechia, two stringy and thready pulse are unable.Health check-up: external genitalia is grown general, and penis is tiny slightly, and bilateral testes is less than normal, and quality is hard, and the left side deferent duct increases slightly, and the right side deferent duct is thin.Spermatid is not seen in semen efamination, and card belongs to the sterile card of azoospermia.Clothes prolong succeeded the I granule after 36 days, and semen efamination is normal, and its wife is conceived after February.

By paired observation and statistical disposition, total effective rate can reach more than 90% and (see the substantive examination adnexa for details);

2. clinical diagnosis and patient are easy to use, and be directly simple, is convenient to clinical application;

3. it is wide, cheap to produce required crude drug source, and technological process is simple and easy to grasp, and equipment is not had specific (special) requirements, is applicable to suitability for industrialized production.

The present invention will now be further detailed embodiment:

Embodiment 1:

After Radix Ginseng 12 gram, Rhizoma Dioscoreae 10 grams, Rhizoma Atractylodis Macrocephalae preparata 10 grams, the Radix Astragali 10 grams, Fructus Lycii 15 grams, Radix Aconiti Lateralis Preparata 2 grams, Herba Cistanches 15 grams, Semen Nelumbinis 15 grams, Semen Cuscutae 15 grams, Fructus Rubi 15 grams, the Radix Aucklandiae 3 grams, Fructus Amomi 3 grams, Cortex Phellodendri 10 grams, Semen Plantaginis 10 grams, Colla Corii Asini 15 grams are cleaned, dry, pulverize with clear water, putting into extraction pot adds clear water immersion 50 minutes, injects steam, make temperature be controlled at 110 ℃, decocted 80 minutes, and carried out dynamic extraction while decocting; Extracting solution is carried out vacuum and low temperature concentrate, put into spray dryer after concentrating and carry out the high velocity fog drying again, to make extract powder, temperature is controlled at 110 ℃ during spray drying; Exsiccant extract powder is put into Drygranulatemachine directly be pressed into granule, at last granule is packed.

Embodiment 2

After Radix Ginseng 15 gram, Rhizoma Dioscoreae 15 grams, Rhizoma Atractylodis Macrocephalae preparata 15 grams, the Radix Astragali 15 grams, Fructus Lycii 20 grams, Radix Aconiti Lateralis Preparata 5 grams, Herba Cistanches 20 grams, Semen Nelumbinis 20 grams, Semen Cuscutae 20 grams, Fructus Rubi 20 grams, the Radix Aucklandiae 5 grams, Fructus Amomi 5 grams, Cortex Phellodendri 15 grams, Semen Plantaginis 15 grams, Colla Corii Asini 20 grams are cleaned, dry, pulverize with clear water, put into extraction pot and add clear water immersion 90 minutes, inject steam, just temperature is controlled at 130 ℃, decocted 100 minutes, and extracted while decocting; Extracting solution is carried out vacuum and low temperature concentrate, put into spray dryer after concentrating and carry out the high velocity fog drying, to make extract powder, spray-dired temperature is controlled at 160 ℃; Exsiccant extract powder is put into the Drygranulatemachine pelletize it directly is pressed into granule, at last granule is packed.

Embodiment 3

With Radix Ginseng 13.5 gram, Rhizoma Dioscoreae 13 grams, Rhizoma Atractylodis Macrocephalae preparata 13 grams, the Radix Astragali 13 grams, Fructus Lycii 17.5 grams, Radix Aconiti Lateralis Preparata 3.5 grams, Herba Cistanches 13 grams, Semen Nelumbinis 17.5 grams, Semen Cuscutae 17.5 grams, Fructus Rubi 17.5 grams, the Radix Aucklandiae 4 grams, Fructus Amomi 4 grams, Cortex Phellodendri 13 grams, Semen Plantaginis 13 grams, Colla Corii Asini 17.5 grams with clear water clean, oven dry, pulverize after, put into extraction pot and add clear water immersion 60 minutes, inject steam, just temperature is controlled at 120 ℃, decocted 90 minutes, and extracted while decocting; Extracting solution is carried out vacuum and low temperature concentrate, put into spray dryer after concentrating and carry out the high velocity fog drying, to make extract powder, spray-dired temperature is controlled at 130 ℃; Exsiccant extract powder is put into Drygranulatemachine directly be pressed into granule, at last granule is packed.

Claims (2)

1. one kind is prolonged heir's granule, it is characterized in that being being made by the raw material of following weight ratio: Radix Ginseng 2.4～3, Rhizoma Dioscoreae 2～3, Rhizoma Atractylodis Macrocephalae preparata 2～3, the Radix Astragali 2～3, Fructus Lycii 3～4, Radix Aconiti Lateralis Preparata 0.4～1, Herba Cistanches 3～4, Semen Nelumbinis 3～4, Semen Cuscutae 0.6～1, Fructus Rubi 2～3, the Radix Aucklandiae 3～4, Fructus Amomi 3～4, Cortex Phellodendri 2～3, Semen Plantaginis 0.6～1, Colla Corii Asini 3～4.

2, the preparation method of the described granule of claim 1, it is characterized in that finishing according to the following steps: after Radix Ginseng, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae preparata, the Radix Astragali, Fructus Lycii, Radix Aconiti Lateralis Preparata, Herba Cistanches, Semen Nelumbinis, Semen Cuscutae, Fructus Rubi, the Radix Aucklandiae, Fructus Amomi, Cortex Phellodendri, Semen Plantaginis and Colla Corii Asini cleaning, drying, pulverizing, putting into extraction pot soaked more than 50 minutes, inject steam, temperature is controlled at 110～130 ℃ and decocted 80～100 minutes, carries out dynamic extraction while decocting; Extracting solution is carried out after vacuum and low temperature concentrates, and spray drying is to make extract powder, and spray-dired temperature is after 110～160 ℃, packs after extract powder is pressed into graininess.