CN1058869C - Chinese traditional medicine of hair lotion and preparing process - Google Patents
Chinese traditional medicine of hair lotion and preparing process Download PDFInfo
- Publication number
- CN1058869C CN1058869C CN93108432A CN93108432A CN1058869C CN 1058869 C CN1058869 C CN 1058869C CN 93108432 A CN93108432 A CN 93108432A CN 93108432 A CN93108432 A CN 93108432A CN 1058869 C CN1058869 C CN 1058869C
- Authority
- CN
- China
- Prior art keywords
- host
- vitamin
- adjuvant
- hair growth
- growth promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The present invention provides a traditional Chinese medicine for hair growing and the preparation method of the medicine, which treats alopecia and has the functions of hair cultivation and beautification. As proved by a large amount of clinical verification, the medicine is the pilatory which has better curative effect on treating various kinds of alopecia and has no toxic or side effect.
Description
The present invention relates to a kind of alopecia for the treatment of and educate the Chinese medicine preparation of sending out beautification function with having.
Alopecia is a kind of global commonly encountered diseases and frequently-occurring disease, can be caused by the various causes of disease, and susceptible disease in poor crowd is outstanding many these diseases of developed country.Though this disease is attractive in appearance because of hindering to the directly influence of healthy nothing, often make many patients worried uneasy, up to influencing work, study and marriage.The patient sees a doctor anxious, and the medicine of the normal determined curative effect for want of of doctor and powerless.
At present, in the treatment alopecia medicine more representative have following several: what the general powerful pharmaceutical factory of US business produced " falls to building (Regaine
) hair stimulator " be to develop on the basis of accidental hirsutism side effect with loniten treatment hypertension the time, total effective rate of its treatment seborrheic alopecia is 35.83%; " ZHANGGUANG board 101 HAIR REGENERATING MEDICINE " (seeing the report " healthy hair can be regenerated " of " rehabilitation " magazine fourth phase in 1988) once was subjected to attracting attention both at home and abroad, but in being extensive use of, find, this medicine has stronger local irritant effect, can occurring after some patient uses wets examines, erosion, also allergic symptom can appear, problem aspect producing, also exist in the transportation safety (Asahi Shimbun sunset periodical, on June 18th, 1988); " the chrysanthemum beauty joins liquid for hair-growth " that Shanghai Shen Guang pharmaceutical factory produces is to be that the nutrition that primary raw material is prepared is become visible with the Radix Ginseng, and its mechanism of action owes bright, and curative effect is also uncertain, may be effective to alopecia areata.
The object of the present invention is to provide a kind of determined curative effect and do not have the hair growth promoter of toxicity.
The present invention also aims to provide the preparation method of this hair growth promoter.
The inventor is discarded the dross and selected the essential on the basis of secret prescription handed down in the family from generation to generation, and the science compatibility has been done a large amount of experiments and clinical verification, succeeds in developing specially good effect hair growth promoter of the present invention finally.
The prescription of hair growth promoter of the present invention is as follows:
1. host
％
Rhizoma Gastrodiae 0.5-2.0
Herba Clinopodii Polycephali 1.0-4.0
Nepal knotweed 1.0-4.0
Fructus Zanthoxyli (viewing and admiring green pepper) 0.3-0.5
Capital rhizome of chuanxiong (Rhizoma Chuanxiong) 1.0-4.0
Radix Salviae Miltiorrhizae 1.0-4.0
Radix clerodendri bungei 1.0-4.0
Herba Epimedii (Herba Epimedii) 1.0-2.0
Resorcin (resorcinol) 0.5-3.0
75% ethanol adds to 100.0
2. adjuvant (compound recipe dilute alcohol solution)
％
Vitamin E 0.05-0.1
Vitamin B
60.05
Antioxidant 0.1-0.5
Chelating agent 0.2-0.5
3-methylcyclopentadecanol 1.0
Propylene glycol 10.0
Glycerol 20.0
75% ethanol adds to 100.0
Wherein, antioxidant can be vitamin C, linoleic acid etc.; Chelating agent can be EDTA, dimercaptopropanol, BAL etc.
In the present invention's prescription, the effective ingredient of Herba Clinopodii Polycephali, nepal knotweed etc. is a ferulic acid, has the effect that suppresses PDE, can improve cAMP (cAMP) content in the cell, promotes hair follicle regeneration; Fructus Zanthoxyli (viewing and admiring green pepper) contains vasodilatin sample material, increases the nutrition permeability of hair follicle; Radix Salviae Miltiorrhizae contains TANSHINONES, has the blood activating and fat reducing effect, and improves the cAMP level, is beneficial to early stage seborrheic alopecia; Radix clerodendri bungei contains paeoniflorin, and calm blood fat reducing improves cAMP, and it is bald to be beneficial to speckle; Herba Epimedii (Herba Epimedii) contains plant sterol Herba Epimedii glycoside (icariine), tonifies Qi of the kidney, and is beneficial to that god declines, male pattern alopecia; Rhizoma Gastrodiae contains cephrol, suppressing the hyperactive liver to relieve the wind syndrome, and the arresting convulsion relieving convulsion, effective to nervous alopecia.
Adjuvant in the present invention's prescription helps medicine and infiltrates, the performance better therapeutic.
Hair growth promoter of the present invention can be prepared as follows;
1. each medicine coarse powder soak with ethanol of host is immersion 24-48 hour preferably;
2. filter and remove residue, filtrate adds purified talc, leaves standstill after the stirring, preferably for leaving standstill 2 hours;
3. filter, filtrate adds active carbon, stirs, and filters;
4. filtrate is adjusted total amount and is contained the alcohol amount with distilled water and 95% ethanol, and containing the alcohol amount is 75 ± 5%;
5. with host and adjuvant mixed in equal amounts.
Below with embodiment the present invention is done a step and describes, this embodiment is not a limitation of the present invention.
Embodiment
Feed intake by 100ml * 5000 bottle output, each crude drug mixes after being ground into moderately coarse powder, and in five stainless steel casks of packing, every barreled crude drug powder 13.5kg adds ethanol 86.5kg.
Soaked 48 hours, filtration is removed slag, and filtrate was left standstill 24 hours after stirring, and microgranule is expanded, and adds Pulvis Talci (in 1.0%), stirs and leaves standstill 2 hours, and filtrate adds filter paper pulp, mixes and stirs, and adds active carbon and stirs, and filters.Add ethanol after filtrate is weighed and be adjusted to capacity.Contain alcohol amount 75%, total amount 500kg.
Above-mentioned host is added the equivalent adjuvant, spend the night after the stirring, bottle after the quality inspection.
Quality examination:
1. perusal: clear and bright, Natural color, no muddiness, do not have precipitation.
2. abnormal smells from the patient: Chinese medicine fragrance.
3. reagent inspection: get finished fluid 5ml, place in vitro, add diethyl ether several, add 10% sodium hydroxide 2ml again, put on the alcohol burner and boil, be bright cherry red (for certified products).
4.pH4-7
5. hygienic chemistry: Hb≤30.0ppm is qualified
Hg≤1.00ppm is qualified
As≤7.0ppm. is qualified
6. microbiology: total plate count (individual/gram)＜1000 is qualified
Colibacillus of excrement must not detect, for qualified
Bacillus pyocyaneus must not detect, for qualified
Staphylococcus aureus must not detect, for qualified
More than every inspection all qualified.
Experimental example
1. drug inspection
Entrust japanese food analysis center to do the heavy metal test, exploitation is all together the biological group of research department of portion and is made microbiological test, and the result is as follows:
(1) heavy metal test
Pb ＜0.05ppm
As is (with As
2O
3Meter)＜0.1ppm
Hg (total hydrargyrum)＜0.01ppm
(2) microbiological test: general bacterioscopy plain agar culture medium, the inspection of a fungus yeast glucose protein agar culture medium.In culture medium, add sample, preserved 7 days down, microbe colony do not occur, do not detect antibacterial, fungus and yeast in 30 ℃.
(3) pH value: stock solution pH4.34
10 times of diluent pH4.45 of distilled water
Because the isoelectric point, IP of hair is before and after the pH4.5, as educating a mao agent, the pH value of these goods suits.
(4) stability: 48 ℃ ± 1 ℃, placed 24 hours, placed 24 hours, and there is no precipitation, variable color etc. for 10 ℃.
2. animal experiment
(1) guinea pig skin test
Experiment is assisted to finish by Shanghai City work hygiene prevention and cure of occupational disease institute.Method is to wipe to guinea pig skin every day 2 times use hair growth promoter of the present invention, observes the thin vasodilation hyperemia of Cavia porcellus intradermal fur after 15 days, the interior hair quality active growth of hair follicle with polariscope; Be converted into the hair number than the matched group height by epithelium in the medication group guinea pig skin hair follicle after 30 days.
(2) tame lagophthalmos conjunctiva irritant test
Test is finished by Jiangsu Province's Experimental Animal Center.Laboratory animal adopts new zealand rabbit (body weight 2-3kg).Get hair growth promoter solution 0.1ml of the present invention and splash in the rabbit conjunctival capsule, it is all normal to observe conjunctiva, iris, cornea after 6 hours, 24 hours, 48 hours, 72 hours.By GB7919-87 grade scale integration is zero, shows the eye nonirritant.
3. to the observation of curative effect of seborrheic alopecia
Xinhua Hospital Attached to Shanghai No.2 Medical Univ has carried out observation of curative effect with hair growth promoter of the present invention to seborrheic alopecia.The seborrheic alopecia patient stochastic sampling of outpatient service diagnosis and treatment is divided into two groups: experimental group is selected hair growth promoter of the present invention for use; Matched group is selected the loniten lotion of 2% loniten, 5% Radix Ginseng, 16% propylene glycol and ethanol preparation for use.The affected part hot compress was applied medicinal lotion or ointment by group after 5-10 minute, and every day 2 times, 30 days is a course of treatment, observes 6 courses of treatment continuously.Curative effect is divided 4 grades: (1) is effective: pruritus and alopecia stop, or the growth of companion's pubescence; (2) produce effects: pubescence length surpasses 1.5cm, and quantity is near normality; (3) recovery from illness: the pubescence color and luster increases deeply, and hair shaft increases slightly, forms terminal hair, can reach cosmetic purpose; (4) invalid: do not have above-mentioned three showers claim invalid.The results are shown in Table 1.
Table 1
Experimental group (84 example) matched group (67 example)
The example routine number of number (%) (%)
Effective 26 (30.9) 10 (14.93)
Produce effects 24 (28.57) 12 (17.91)
Recovery from illness 6 (7.14) 2 (2.99)
Invalid 28 (33.33) 43 (64.17)
Total effective rate 66.67%
*35.82%
*There is the highly significant meaning P＜0.01, difference.
4. clinical efficacy is verified comprehensive report
The unit of clinical efficacy checking is carried out in assistance: the attached Shanghai Long March Hospital of Second Military Medical University, PLA, Xinhua Hospital Attached to Shanghai No.2 Medical Univ, Longhua Hospital of Chinese Midicine Univ. of Shanghai and SHUGUANG HOSPITAL, Shanghai City Changning District central hospital, the white hospital of Yangpu, the Shanghai City head of district, Shanghai City federation of trade unions workers' sanatorium.
Be three months each course of treatment, and four courses of treatment of some cases medication, shared this product is treated all kinds of alopecia 507 examples, and every curative effect index is respectively:
A. alopecia areata 191 examples: obvious effective rate 54.45%, effective percentage 32.46%, total effective rate are 86.91% (hair growth promoting effective percentage).
B. seborrheic alopecia 316 examples: obvious effective rate 46.83%, effective percentage 19.93%, total effective rate are 66.77% (hair growth promoting effective percentage).
C. all kinds of carrying out property alopecia 237 examples: obvious effective rate 56.96%, effective percentage 27.0%, total effective rate 83.96% (control alopecia effective percentage).
D. seborrhea infringement 200 examples: total obvious effective rate 91.82% of all 68.13%, two weeks of obvious effective rate (suppress seborrhea, eliminate dandruff, the upright scalp play effective percentage of itching that ends).
In sum, Chinese medicine hair growth promoter of the present invention has curative effect preferably to all kinds of alopecias, and does not have obvious toxic and side effects, is a kind of safe and effective hair growth promoter.
Claims (5)
1. a hair growth promoter is made up of host and adjuvant, and wherein host is to contain 75 ± 5% alcoholic acid solution by what the raw material of following consumption was made:
％
Rhizoma Gastrodiae 0.5-2.0
Herba Clinopodii Polycephali 1.0-4.0
Nepal knotweed 1.0-4.0
View and admire green pepper 0.3-0.5
Rhizoma Chuanxiong 1.0-4.0
Radix Salviae Miltiorrhizae 1.0-4.0
Radix clerodendri bungei 1.0-4.0
Herba Epimedii 1.0-2.0
Resorcin 0.5-3.0.
2. hair growth promoter as claimed in claim 1 is characterized in that, wherein adjuvant is to contain 75% alcoholic acid solution by what the raw material of following consumption was made:
％
Vitamin E 0.05-0.1
Vitamin B
60.05
Antioxidant 0.1-0.5
Chelating agent 0.2-0.5
3-methylcyclopentadecanol 1.0
Propylene glycol 10.0
Glycerol 20.0
3. prepare the method for the described hair growth promoter of claim 1, it is characterized in that may further comprise the steps:
(1) with each crude drug coarse powder of soak with ethanol host, filter, adsorption bleaching, it is 75 ± 5% that adjustment contains the alcohol amount, adds 75% alcoholic solution of resorcin, obtains following host solution:
％
Rhizoma Gastrodiae 0.5-2.0
Herba Clinopodii Polycephali 1.0-4.0
Nepal knotweed 1.0-4.0
View and admire green pepper 0.3-0.5
Rhizoma Chuanxiong 1.0-4.0
Radix Salviae Miltiorrhizae 1.0-4.0
Radix clerodendri bungei 1.0-4.0
Herba Epimedii 1.0-2.0
Resorcin 0.5-3.0
(2) be formulated as follows adjuvant solution with 75% ethanol:
％
Vitamin E 0.05-0.1
Vitamin B
60.05
Antioxidant 0.1-0.5
Chelating agent 0.2-0.5
3-methylcyclopentadecanol 1.0
Propylene glycol 10.0
Glycerol 20.0
(3) with host and adjuvant mixed in equal amounts.
4. method as claimed in claim 3, wherein soak time is 48 hours.
5. method as claimed in claim 3, wherein said adsorption bleaching comprise and add purified talc respectively and active carbon stirs, leaves standstill and filtering step.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93108432A CN1058869C (en) | 1992-07-22 | 1993-07-12 | Chinese traditional medicine of hair lotion and preparing process |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92108692 | 1992-07-22 | ||
| CN92108692.X | 1992-07-22 | ||
| CN93108432A CN1058869C (en) | 1992-07-22 | 1993-07-12 | Chinese traditional medicine of hair lotion and preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1084760A CN1084760A (en) | 1994-04-06 |
| CN1058869C true CN1058869C (en) | 2000-11-29 |
Family
ID=25742782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93108432A Expired - Fee Related CN1058869C (en) | 1992-07-22 | 1993-07-12 | Chinese traditional medicine of hair lotion and preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1058869C (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031022A (en) * | 1988-07-01 | 1989-02-15 | 天津市轻工业化学研究所 | A kind of channel-stimulating and hair-growing hair shampoo |
| CN1035436A (en) * | 1988-12-28 | 1989-09-13 | 王玉花 | A kind of manufacture method of hair growth promoter |
| CN1058900A (en) * | 1991-05-21 | 1992-02-26 | 焦学恩 | A kind of preparation method of HAIR REGENERATING SOLUTION |
-
1993
- 1993-07-12 CN CN93108432A patent/CN1058869C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031022A (en) * | 1988-07-01 | 1989-02-15 | 天津市轻工业化学研究所 | A kind of channel-stimulating and hair-growing hair shampoo |
| CN1035436A (en) * | 1988-12-28 | 1989-09-13 | 王玉花 | A kind of manufacture method of hair growth promoter |
| CN1058900A (en) * | 1991-05-21 | 1992-02-26 | 焦学恩 | A kind of preparation method of HAIR REGENERATING SOLUTION |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1084760A (en) | 1994-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20090117146A1 (en) | System and method for promoting hair growth and improving hair and scalp health | |
| CN104872656B (en) | A kind of composition with health care function and preparation method thereof | |
| CN101829240B (en) | Atomizing preparation containing plant extract and preparation method thereof | |
| CN1058869C (en) | Chinese traditional medicine of hair lotion and preparing process | |
| CN101972334B (en) | Traditional Chinese medicine preparation for preventing and treating infantile eczema and preparation method thereof | |
| TWI780840B (en) | An extract of sarcodia and uses thereof | |
| CN108567914A (en) | It is a kind of that there is the Chinese medicine preparation and its preparation method and application for improving sleep effect | |
| CN113117012B (en) | Medicine for treating chronic liver injury and preparation method and application thereof | |
| CN1943570A (en) | Use of opc in preparing medicine for treating and preventing senile dementia | |
| CN1176697C (en) | Antisenility medicine composition and its prepn | |
| CN1899553A (en) | Paste for treating dental hyperesthesia and its preparing method | |
| CN1060342C (en) | Application of liver oil of globefish in preparation of medicines for drug dependence | |
| CN1723933A (en) | Traditional Chinese medicine capsule for treating application, and its prodn. method | |
| CN1386511A (en) | Medicine for preventing and treating senile dementia | |
| RU2087154C1 (en) | Method of preparing the agent for treatment of chronic cholecystitis and showing cholagogue and hepatoprotective effect | |
| CN1176689C (en) | Medicine for treating primary dysmenorrhea and its prepn | |
| WO2012127498A2 (en) | A novel herbal composition for the treatment of kidney stone and other urinary tract disorders | |
| CN1569164A (en) | Blood lead content reducing medicine for treating plumbism | |
| CN1283246C (en) | Complex rheum officinale-radix scutellariae extract injecta for treating acute pancreatitis and preparing method thereof | |
| CN1121237C (en) | Health-care products for regulating immunological function and delaying senility | |
| CN1895341A (en) | Chinese-medicinal preparation for treating cardiovascular and cerebrovascular diseases | |
| CN1468617A (en) | Chinese medicine prepn for treating spondylosis | |
| CN109745431A (en) | For treating the herb mixture and its preparation method and application of psoriasis and onychomycosis | |
| CN1530101A (en) | Healthy food composition for purifying blood, improving immunity and regulating blood fat | |
| CN1102403C (en) | Huanyang oral liquid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |