CN105878801A - Red kojic rice astaxanthin composition with blood lipid lowering effect - Google Patents

Red kojic rice astaxanthin composition with blood lipid lowering effect Download PDF

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CN105878801A
CN105878801A CN201610303661.0A CN201610303661A CN105878801A CN 105878801 A CN105878801 A CN 105878801A CN 201610303661 A CN201610303661 A CN 201610303661A CN 105878801 A CN105878801 A CN 105878801A
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composition
astaxanthin
phytosterol
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extract
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胡铭
南敏伦
赫玉芳
曲佳乐
王孝方
邹慧
赵全成
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella

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Abstract

The invention relates to a composition which takes red kojic rice extract, astaxanthin and phytosterol as main components. The composition has blood lipid regulation effect. The composition has clear components and is prepared by compounding three different medicinal substances; the blood lipid regulation effect is expressed by utilizing different acting principles and target points; the composition has the characteristics of small oral dosage and capability of being both used as medicine and food and is a safe and effective composition for lowering blood lipid; compared with single red kojic rice extract, the astaxanthin and the phytosterol, the composition has stronger blood lipid lowering activity. The synergistic effect of the compound composition is represented and the composition can be used for preparing medicines and health foods, which have the blood lipid regulation effect.

Description

A kind of red colouring agent for food, also used as a Chinese medicine astaxanthin composition with effect for reducing blood fat
Technical field
The present invention relates to a kind of composition with red yeast rice extract, astaxanthin and phytosterol as main component.This group Compound has effect for reducing blood fat, can be used for prevention and treats the cardiovascular and cerebrovascular disease caused by hyperlipemia.The present invention also relates to The pharmaceutical preparation of this medicine, belongs to pharmaceutical technology field.
Background technology
Fat metabolism or operating make one or more lipids of blood plasma extremely higher than being just frequently referred to hyperlipemia.Hyperlipemia is A kind of systemic disease, refers to blood cholesterol (TC) and/or triglycerides (TG) is too high or HDL-C (HDL-C) too low.The main harm of hyperlipemia is to cause atherosclerotic, and then causes numerous relevant diseases, this disease To the infringement of health be concealment, gradually, Progressive symmetric erythrokeratodermia and general.Its directly infringement is to accelerate systemic atherosclerosis, Because the vitals of whole body will rely on artery blood supply, oxygen supply, once artery is blocked by atheromatous plaque, after may result in seriously Really.The renal failure etc. that artery sclerosis causes, all closely related with hyperlipemia.Numerous studies data shows, hyperlipemia It is cerebral apoplexy, coronary heart disease, myocardial infarction, cardiac sudden death independently important hazards.Sending out of these cardiac and cerebral vascular diseases Sick rate is high, and harm is big, and disease progression is dangerous, and its death rate accounts for about the half of mankind's general mortality rate.Adjust blood fat at present Medicine is a lot, is broadly divided into following three classes: (1) Statins, to reduce cholesterol, such as simvastatin, Provastain etc.；(2) shellfish Special class: to reduce triglycerides, such as promise weighing apparatus, lipanthyl etc.；(3) crude drug species, to reducing cholesterol and triglycerides All effective, and with increasing high density lipoprotein, can have effect of comprehensive adjustment blood fat, and side effect is little, board lipopenicillinase as safe in dragon Peaceful etc..Because it is a process slowly that blood fat increases, the regulation of blood fat particularly eliminates the harmful effect of blood fat and needs too Wanting the process of a continuous action, therefore patient should select the obvious medicine of effect for reducing fat according to the different situations of self.Cause This, a fat-reducing medicament safe and effective, that toxic and side effect is little, just required for hyperlipemic patients.This patent of our invention Meet the application in terms for the treatment of high fat of blood of the natural drug of this condition just.
The present invention has the advantages that to utilize Chinese medicine " Mutiple Targets, manifold effect ", scientific and reasonable by blue or green to red yeast rice extract, shrimp Element and phytosterol prescription, can be used for preventing and treat hyperlipemia, the present invention to find no pass before completing and extract with red yeast rice The composition of thing, astaxanthin and phytosterol composition, as the report of preventing and treating hyperlipidaemic conditions medicine, does not finds both prescriptions yet Apply for preventing and treating the clinicing aspect of hyperlipidaemic conditions.
Red yeast rice is with rice such as long-grained nonglutinous rice, japonica rice, glutinous rice as raw material, forms, for brownish red or purple with monascus ruber fermentation The red grain of rice.Red yeast rice extract is the extract utilizing red yeast rice to obtain through alcohol extract.In red yeast rice, Main Function becomes Dividing is Lovastatin and monascorubin.Monascorubin is the mixture of multiple pigment, and mainly having red colour system and yellow is 2 big classes, These pigments are all polyketides.Using value is concentrated mainly on the pigment of 6 kinds of alcohol-soluble: red erythema red colouring agent for food, also used as a Chinese medicine amine (Rubropunctamine), red colouring agent for food, also used as a Chinese medicine rubine amine (Monascrubramine), orange erythema Monascin (Rubropunctatin), red colouring agent for food, also used as a Chinese medicine rubine element (Mon-ascorubrin), the Monascus anka flavine (Ankaflabin) of yellow, red Qu Su (Monascin) (Xijun Lian etc., Dyes and Pigments, 2007, (73): 121-125).Red yeast rice has fall Low T-CHOL (TC), reduces LDL-C (LDL-C), reduces triglycerides (TG), improves high density simultaneously Lipoprotein (HDL-C), plays the effect of lowering blood pressure and blood fat.And also reinforcing spleen to promote digestion, effect promoting blood circulation and removing blood stasis.
Astaxanthin is extraction isolated from haematococcus haematococcus pluvialis (Haematococcus pluvialis). Astaxanthin has stronger antioxidation activity, has removing free radical, protection blood vessel, reduces cholesterol, skin care, protection eyesight, guarantor Protect nervous system, prevention senile dementia, alleviate many nutrition health-care functions such as arthralgia (Trends Biotechnol, 2003,21 (5): 210).Research shows that astaxanthin can substantially reduce level and the raising HDL levels (Arch of LDL in blood Latinoam Nutr, 1992,42 (4): 409-413)；Luo Ren bravely studies and shows, gives high fat diet animal and natural shrimp simultaneously After blue or green element 30d, TC, TG level substantially reduces, and control group TC and TG persistent levels raise, although and HDL-C level has reduction Trend, but not statistically significant, illustrate natural astaxanthin truly have reduce TC Yu TG effect (modern preventive medicine, 2009, the Volume 36 the 4th phase)；Li Hongyan research shows, astaxanthin has a good fat-reducing effect, and the sustainer that induces high fat and liver Lipid peroxidation injury have obvious inhibiting effect, high dose (10mg/kg) astaxanthin improve effect more preferably (Hebei medicine, 2012, volume 34, the 1st phase)；Pei Lingpeng research shows, high lipid food is fed lower Rat Induced hyperlipidemia mistake by astaxanthin In journey, blood lipid metabolism has intervention effect.TC, TG, LDL-C of astaxanthin group significantly reduce, and HDL-C raises, and illustrates, shrimp is blue or green High lipid food can be fed the blood lipid metabolism during Rat Induced hyperlipidemia and be produced impact by element, improve Blood Lipid (in State's gerontology magazine, in September, 2012 volume 32)；The Yellow River scholar research shows, haematococcus pluvialis extract can significantly reduce modeling sugar The blood sugar level of the sick mouse of urine, alleviates many drinks, many foods, diuresis and the symptom that loses weight, significantly improves the sugar tolerance of disease mouse body And insulin tolerance, promote its Utilization ability to glucose, effectively the blood fat disorder of the sick mouse of regulation, improves blood environment, and Blood sugar and the blood fat of normal mouse are not made significant difference (journal of Zhejiang university agricultural and life science version, 2015, volume 41, 642)。
Phytosterol (phytosterol or plant sterol) is a kind of active component in plant, structurally Similar to animality sterol such as cholesterine.It is widely present in each vegetable oil, nut and vegetable seeds, exists in other and plant In physical property food such as vegetable and fruit.Have reduction blood cholesterol content, suppress tumour, prevent and treat hypertrophy of the prostate, suppression mammary gland The aspects such as hyperplasia and regulation immunity all play an important role.Research proves, phytosterol can substantially reduce T-CHOL in blood And low-density lipoprotein (LDL) content (TC), and do not reduce HDL (HDL) and content of triglyceride, make LDL with HDL ratio reduces, and does not has any obvious side effect (Am J Med, 1999,107 (6): 588-594).Blair etc. exist Experiment also demonstrates phytosterol hyperlipidemia is had adjuvant treatment effect (Am J Cardiol, 2000,8 (6): 46-52)； The research of Becker etc. also demonstrates the children taking sitosterol of serious familial hyperlipidemia and can obviously reduce blood lipid level, right Reduce cardiovascular and cerebrovascular diseases after it is grown up and have positive effect (J Pediatr, 1993,122 (2): 292-296)；Sierksma etc. are right The double blind control research that 76 health adults's (44 years old mean age) are carried out finds, compared with control group, takes sojasterol 0.8g/d 3 Zhou Houke significantly reduces TC and LDL in blood, but will not cause other liposoluble vitamin such as carotenoid levels in blood Decline, therefore now scientists generally believes absorption or supplements enough phytosterols and contribute to reduction crowd's coronary heart disease The incidence of disease (Tidsskr Nor Laegeforen, 2000,120 (22): 2661-2665).
Above-named prior art the not met mankind constantly improve the demand of lipopenicillinase, the particularly requirement of Mutiple Targets with And the requirement of lipopenicillinase further.
It is an object of the invention to provide the composition of a kind of effect for reducing blood fat of starting with from " Mutiple Targets, manifold effect ", have, Active component is made up of red yeast rice extract, astaxanthin and phytosterol.
Although prior art individually disclosing red yeast rice, astaxanthin and phytosterol all there is effect for reducing fat, but, do not have Have and combined the report for lipopenicillinase.The present inventor, according to different proportion formula, finds through a large amount of screening tests, There is complementarity at Jiangzhi Recipe mask after three's raw material is compounding, after red yeast rice extract, astaxanthin and phytosterol are combined, expect More preferable effect is obtained less than ground.
The present composition more single red yeast rice extract, astaxanthin and phytosterol have the pharmacology become apparent from and live Property.Therefore, the present inventor carries out scientific and reasonable prescription to three, has obtained having prevention and treatment hyperlipemia combination Thing.Three starts with from different angles and reaches the effect of reducing blood lipid.Before the present invention completes, also do not have by red yeast rice extract, shrimp The composition of blue or green element and phytosterol composition has the report of anti-curing hyperlipemia.
Summary of the invention
Goal of the invention is to provide one and is grouped compound by red yeast rice extract, astaxanthin and phytosterol, is used for preventing Effect with treatment hyperlipemia.Further, the present inventor is by further investigation revealed that, red yeast rice extracts Thing, astaxanthin and phytosterol by a certain percentage fill a prescription composition composition more single red yeast rice extract, astaxanthin and plant Sterol has more obvious action at regulation lipid aspects.This natural pharmaceutical composition is the present inventor's first passage testing sieve Choosing obtains, and also embodies the synergy of herbal mixture, has prominent contribution and significantly technological progress.
Another outstanding contributions of the present invention are, give birth to red by the extract extracted in red yeast rice edible for people, rain The astaxanthin extracted in ball algae and phytosterol composition, first for medicine, health food or food.
Meanwhile, this product preparation technology is simple, embodies cheap advantage.And this product determined curative effect, nontoxic secondary work With, taking convenience, formulation science, embody the practicality of the present invention.
The present invention is by the containing oxygen derivative astaxanthin containing carotenoid, red yeast rice extract containing natural Statins and contains There is the phytosterol prescription of similar cholesterol, start with from different action target spots, mutually synergy reaches the effect of reducing blood lipid. By reducingT-CHOL(TC), reduceLow-density lipoproteinCholesterol (LDL-C), reduce triglycerides (TG), improve simultaneouslyHDL(HDL-C)；Auxiliary by the rate-limiting enzyme hydroxyl first glutaryl during the internal cholesterol biosynthesis of suppression competitively Enzyme A reductase, make the synthesis of cholesterol reduce, also make LDL receptor synthesis increase；People can be suppressed by having The effects such as katabolism that body to the absorption of cholesterol, promotes cholesterol, the biochemical synthesis of suppression cholesterol；By seizing bad courage Sterol position in enteron aisle, and promote it to excrete, thus reduce T-CHOL and the content of bad cholesterol in blood, with Time had no effect on the content of cholesterol.Thus reach the effect of reducing blood lipid.
The invention provides a kind of composition with effect for reducing blood fat, by astaxanthin 1-20 part, phytosterol 10-450 Part, red yeast rice extract 20-500 part forms.Preferably astaxanthin 10 parts, phytosterol 350 parts, red yeast rice extract 350 parts.Its Proportionally mixing composition active ingredient and pharmaceutic adjuvant are made.
It is a further object of the present invention to provide the preparation method with effect for reducing blood fat composition, comprised the steps:
(1) red yeast rice 6-10 times amount 50-85% edible ethanol is extracted 2-3 time, extract 2-3 hour every time, extract temperature Degree is 50～80 DEG C, and extract filters, filtrate recycling ethanol, concentrates, is dried to obtain red yeast rice extract；
(2) haematococcus pluvialis is put in flash extracter and extract 2-3 time with 60-95% edible ethanol, extract 2-3 little every time Time, Extracting temperature is 50-80 DEG C, filters, and reclaims ethanol, is dried to obtain haematococcus astaxanthin；
(3) add auxiliary material after red yeast rice extract, astaxanthin and phytosterol proportionally being mixed uniform, make Oral formulations.
The composition (abbreviation composition) being made up of red yeast rice extract, astaxanthin and phytosterol has preventing and treating high fat of blood Disease acts on, and is confirmed by following pharmacodynamic experiment.
Experimental raw: the composition used in this pharmacodynamics and single extract are inventor and provide.This pharmacodynamics is tried The red yeast rice extract mentioned in testing is the sample that example 1 extracts；Astaxanthin is the sample that example 2 extracts；Phytosterol is purchased from The phytosterol extracted in soybean.The present composition is sample (the red yeast rice extract: phytosterol: shrimp is blue or green of example 3 preparation Element=35:35:1), raw material used is that the extraction of example 1-2 extracting method obtains.
The blood fat recovery capsule used in this pharmacodynamics test is that Beijing WBL Peking University Biotech Co., Ltd produces, lot number For: 20150801.
1, this product composition impact on rat TC, TG, HDL-C, LDL-C
Taking male rat 90, be randomly divided into 9 groups, in addition to blank group, remaining is respectively organized and gives high lipid food every day: 2% cholesterol, 10% lard, 0.5% sodium taurocholate, 0.2% propylthiouracil, 87% basal feed.Except blank group certainly Outside by drinking-water, hyperlipidemia model group gives normal saline, and remaining respectively organizes gastric infusion, every day 1 time, is grouped according to table 1, gives Medicine, successive administration 15d.Fasting 12h after medication, measures serum total cholesterol (TC), triglyceride (TG), HDL courage Sterol (HDL-C), serum LDL cholesterol (LDL-C) content, the results are shown in Table 1.
Table 1, this product composition affect result to hyperlipidemia rats blood lipids index
Compare with model control group,*P<0.05；**P<0.01；
Compare with normal group,△P<0.05；△△P<0.01；
Result shows, model control group serum TC, TG, LDL-C value are significantly raised, and HDL-C is decreased obviously.With model comparison Group compares, and this product composition can substantially reduce serum total cholesterol (TC), triglycerides (TG) content, significantly reduces serum low close Degree lipoprotein cholesterol (LDL-C) content, notable increasing serum HDL-C (HDL-C) content.Meanwhile, from reality Test data to show, illustrate that the present composition more single red yeast rice extract, astaxanthin and phytosterol are respectively provided with stronger work Property.
2, hepatic tissue MDA and SOD measures
Last takes animal sacrificed by decapitation after blood, takes rats'liver lobus sinister 0.1g and prepares 10% tissue homogenate, and 3000rpm is centrifuged 15min, then take supernatant 1500rpm and be centrifuged 10min, utilize total protein kit measurement protein concentration (Coomassie Brilliant Blue), press Kit explanation measures MDA content and SOD activity.
Table 2, this product composition are on the impact of MDA and SOD in liver tissues of rats
Compare with model control group,*P<0.05；**P<0.01；
Compare with normal group,△P<0.05；△△P<0.01；
Result shows, this product composition high, medium and low dosage group all has the ability of purged body inner lipid Peroxidation Product MDA, And with the increase of dosage, effect is strengthened.The ability that SOD vigor is also improved.But, either red yeast rice extract, shrimp green grass or young crops Element and the poor activity of phytosterol the most relatively composition.
3, the impact that liver fat is become by this product composition
Taking left lobe of liver, immerse in 20% neutral formalin solution fixing, conventional H E dyes, light Microscopic observation.Result shows, empty White tissue becomes without liver fat, and the change of hyperlipidemia model liver fat reaches more than 90% into severe fatty liver；This product composition low dose group liver fat becomes Being about 60% be moderate fatty liver, and it is 40% to be mild fatty liver that middle dosage group liver fat is altered an agreement, high dose group liver fat alter an agreement into 20% is mild fatty liver.Illustrate that the present composition has suppression fatty liver develop and reverse the effect of fatty liver.Red yeast rice carries Taking thing group (500mg/kg) liver fat and altering an agreement is 55%, for moderate fatty liver；It is 60% that astaxanthin group (500mg/kg) liver fat is altered an agreement, For moderate fatty liver；It is 55% that phytosterol group (500mg/kg) liver fat of the present invention is altered an agreement, for mild fatty liver.Illustrate single red Bent rice extracts, astaxanthin and phytosterol are weak compared with present composition activity.
Knowable to above pharmacodynamic experiment, this product composition has the effect of relatively strongly reducing blood fat.Pharmacological test data is said Bright, the present composition high, medium and low dosage group is respectively provided with significant difference compared with control group, the present composition relatively red colouring agent for food, also used as a Chinese medicine Rice extracts, astaxanthin and phytosterol all show higher pharmacologically active, embody the novelty and significantly of the present invention Technological progress.
The present invention is to be described in detail by the following examples, but is not intended that the invention is limited to this, specifically Embodiment is as follows:
The preparation method of embodiment 1 red yeast rice extract
By red yeast rice 10kg, with 8 times amount 60% alcohol extract 2 times, extracting 2 hours, Extracting temperature is 60 DEG C, extracts every time Liquid filters, filtrate recycling ethanol, concentrates, is dried to obtain red yeast rice extract.
The preparation method of embodiment 2 astaxanthin
Haematococcus pluvialis 10kg is put in flash extracter and extract 3 times with 80% edible ethanol, extract 2 hours every time, carry Taking temperature is 75 DEG C, filters, and reclaims ethanol, is dried to obtain haematococcus astaxanthin.
The preparation method of embodiment 3 composition
Weigh red yeast rice extract 35g, phytosterol 35g, astaxanthin 1g, be uniformly mixed, to obtain final product.
The preparation method of example 4 capsule
Weigh red yeast rice extract 105g, phytosterol 105g, astaxanthin 3g, be uniformly mixed, add appropriate amount of starch, Mix, pelletize, be dried, whole grain, encapsulated, make 1000.Three times a day, each 2.
The preparation method of example 5 tablet
Weigh red yeast rice extract 105g, phytosterol 105g, astaxanthin 3g, be uniformly mixed, add appropriate amount of starch, Mix, pelletize, be dried, whole grain, compressing tablet, make 1000.Three times a day, each 2.

Claims (5)

1. a composition with effect for reducing blood fat, it is characterised in that: active component is by astaxanthin, phytosterol, red yeast rice Extract forms.
A kind of composition with effect for reducing blood fat the most according to claim 1, it is characterised in that it is by following weight The raw material of part is made: astaxanthin 1-20 part, phytosterol 10-450 part, red yeast rice extract 20-500 part.
A kind of composition with effect for reducing blood fat the most according to claim 2, it is characterised in that it is by following weight The raw material of part is made: astaxanthin 10 parts, phytosterol 350 parts, red yeast rice extract 350 parts.
4. according to claim 1-3 one of the arbitrarily described preparation method with effect for reducing blood fat composition, including walking as follows Rapid:
(1) being extracted 2-3 time by red yeast rice 6-10 times amount 50-90% edible ethanol, extract 2-3 hour every time, Extracting temperature is 50～80 DEG C, extract filters, filtrate recycling ethanol, concentrates, is dried to obtain red yeast rice extract；
(2) haematococcus pluvialis is put in flash extracter and extracts 2-3 time with 60-95% edible ethanol, extract 2-3 hour every time, Extracting temperature is 50-80 DEG C, filters, and reclaims ethanol, is dried to obtain haematococcus astaxanthin；
(3) add auxiliary material after red yeast rice extract, astaxanthin and phytosterol proportionally being mixed uniform, make oral Preparation.
5. a composition oral preparation with effect for reducing blood fat, it is characterised in that said preparation is any by claim 1-4 One of described composition make with pharmaceutic adjuvant, this oral formulations is any in capsule, tablet, pill, granule A kind of.
CN201610303661.0A 2016-05-10 2016-05-10 Red kojic rice astaxanthin composition with blood lipid lowering effect Pending CN105878801A (en)

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CN106723023A (en) * 2016-11-29 2017-05-31 内蒙古医科大学 A kind of lipid-lowering health food and preparation method thereof
CN108065392A (en) * 2017-12-05 2018-05-25 杭州鑫伟低碳技术研发有限公司 A kind of composition of assisting in treating hypertension, hyperlipidemic conditions
CN116327814A (en) * 2022-09-08 2023-06-27 健合香港有限公司 Composition for reducing blood fat and cholesterol and preparation method and application thereof

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106723023A (en) * 2016-11-29 2017-05-31 内蒙古医科大学 A kind of lipid-lowering health food and preparation method thereof
CN108065392A (en) * 2017-12-05 2018-05-25 杭州鑫伟低碳技术研发有限公司 A kind of composition of assisting in treating hypertension, hyperlipidemic conditions
CN116327814A (en) * 2022-09-08 2023-06-27 健合香港有限公司 Composition for reducing blood fat and cholesterol and preparation method and application thereof
WO2024050864A1 (en) * 2022-09-08 2024-03-14 健合香港有限公司 Composition for lowering blood lipids and cholesterol, preparation method therefor, and application thereof

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Application publication date: 20160824