CN106723023A - A kind of lipid-lowering health food and preparation method thereof - Google Patents

Abstract

The invention discloses a lipid-lowering health food and a preparation method thereof, which comprises the following ingredients according to the mass ratio: 5-60 parts of buckwheat extract, 5-50 parts of cassia seed extract; 5-50 parts of lotus leaf extract; 5-50 parts of koji rice extract; 5-30 parts of kudzu root extract; 1-30 parts of linseed superfine powder; 1-20 parts of raffinose. The combination of each raw material of the present invention can also treat "dampness, deficiency and numbness" of hyperlipidemia, thereby exerting a synergistic effect. At the same time, it solves the problem that chemical drugs cause health damage to patients due to their serious side effects during treatment; avoids the need to take multiple drugs at the same time because patients with hyperlipidemia are often accompanied by other diseases. The interaction may affect the efficacy of the drug, as well as many possible adverse reactions and side effects.

Description

A kind of fat-reducing health food and preparation method thereof

technical field

The invention belongs to the field of medicine and health care, and in particular relates to a lipid-lowering health food and a preparation method thereof.

Background technique

Hyperlipidemia refers to the high level of blood lipids in the human body, which can directly cause some diseases that seriously endanger human health. For example, hyperlipidemia can lead to liver function damage, and long-term hyperlipidemia can lead to fatty liver and cirrhosis. After blood lipids form atherosclerosis in the human body, it will lead to myocardial dysfunction, angiotensin-converting enzyme will be activated in large quantities, and the blood vessels are often in a state of spasm, and the endothelium of the cerebral blood vessels is damaged after hardening, resulting in rupture and the formation of hemorrhagic cerebral palsy. Stroke, while cerebral blood vessels stagnate in a state of embolic thrombosis, resulting in cerebral thrombosis and cerebral embolism. Hyperlipidemia can also induce coronary heart disease. When the human body forms atherosclerosis due to long-term hyperlipidemia, the blood flow in the coronary arteries becomes smaller, the vascular lumen becomes narrower, and the amount of myocardial blood injection decreases, resulting in myocardial ischemia, resulting in Angina, the formation of coronary heart disease. Hyperlipidemia will harm the coronary arteries and form atherosclerosis. A large amount of esters and proteins will deposit and move in the plasma, reduce the blood flow rate, and deposit on the arterial endothelium after rancidity through oxidation, and adhere to the blood vessel wall for a long time, damaging the arterial endothelium, forming arteriosclerosis. Obese people with hyperlipidemia, due to the relative decrease in the number of insulin receptors, develop insulin resistance and easily induce diabetes. In addition, hyperlipidemia can also cause vision loss, blindness, renal arteriosclerosis, renal failure, limb necrosis, ulceration, gallstones, pancreatitis, male sexual dysfunction, senile dementia and other diseases.

The world's medical community recognizes that hyperlipidemia is the culprit of cardiovascular and cerebrovascular diseases, and cardiovascular and cerebrovascular diseases are one of the most serious diseases threatening human beings in the world today. one. According to the latest statistical data from the Ministry of Health, cardiovascular disease has become the first cause of death among urban and rural populations in my country, accounting for nearly 40% of the causes of death in my country. According to the survey in 2010, the prevalence of hypertension among Chinese adults was as high as 33.5%, and the estimated number of patients reached 330 million, and 450,000 died of hypertension; the prevalence of hypercholesterolemia increased by 1.3 times compared with 2002, high Triglyceridemia increased by 0.8 times, and one fifth of Chinese adults suffer from hypertriglyceridemia.

At present, there are many types of drugs used clinically for lowering blood lipids, but chemical drugs are the main ones, with clear mechanisms of action and definite lipid-lowering effects. However, since the control and treatment of hyperlipidemia requires long-term medication, especially for patients with hypertension, etc., even life-long medication is required, and the health damage caused by chemical drugs to patients due to their serious side effects is also obvious. Most of them have different degrees of liver and kidney damage and stimulation of the digestive system. And statins can also cause non-specific muscle pain or joint pain, severe rhabdomyolysis can be caused. Because patients with hyperlipidemia are often accompanied by other diseases, they need to take multiple drugs at the same time. The interaction between drugs may not only affect the efficacy of drugs, but also produce many adverse reactions and side effects.

Contents of the invention

In view of this, for the inevitable damage that chemical drugs bring to the health of patients during treatment, the object of the present invention is to provide a method of applying buckwheat extract, cassia seed extract, lotus leaf extract, red yeast rice extract, Pueraria root extract, flaxseed, raffinose, etc. are made into health food with lipid-lowering effect. The second purpose of the present invention is to provide a preparation method of the health food.

In order to realize the above-mentioned purpose of the invention, the following technical solutions are specifically provided:

1. A lipid-lowering health food, comprising the following ingredients in proportion by mass: 5-60 parts of buckwheat extract, 5-50 parts of cassia seed extract; 5-50 parts of lotus leaf extract; 5-50 parts of red yeast rice extract 50 parts; 5-30 parts of kudzu root extract; 1-30 parts of linseed superfine powder; 1-20 parts of raffinose.

Preferably, the following ingredients are included in proportion by mass: 40 parts of buckwheat extract, 25 parts of cassia seed extract; 30 parts of lotus leaf extract; 30 parts of red yeast rice extract; 20 parts of kudzu root extract; parts; 5 parts of marshmallow.

Preferably, the buckwheat extract is extracted from the flowers, leaves, seeds, and rhizomes of sweet buckwheat or tartary buckwheat, and the total flavonoid content in the buckwheat extract is not less than 65.0%; The total anthrone content in the extract is not less than 50.0%; the lotus leaf extract is obtained from the lotus leaf extract, and the total alkaloid content in the lotus leaf extract is not less than 50.0%; the red yeast rice extract is obtained from the red yeast rice It is obtained that the content of phytosterol in the red yeast rice extract is not less than 30.0%; the pueraria root extract is obtained by extracting Pueraria root, and the content of puerarin in the pueraria root extract is not less than 30.0%.

Further preferably, the buckwheat extract, cassia seed extract, lotus leaf extract, red yeast extract, and kudzu root extract are extracted according to the following steps:

Preparation of buckwheat extract: take buckwheat flowers, leaves, seeds or rhizomes, add 5 to 15 times the mass of 10 to 90 wt% ethanol, extract at a temperature of 20 to 80°C for 30 to 90 minutes, repeat 1 to 3 times, and combine the extractions solution, recovered ethanol to obtain residual solution I, and the residual solution was absorbed by D101 macroporous resin column, eluted with 10% to 90wt% ethanol at 10°C to 40°C, collected the eluate and separated ethanol to obtain residual liquid II, and the residual liquid II is further dried to obtain the buckwheat extract;

Preparation of cassia seed extract: crush cassia seed, add 5 to 15 times the mass of 10 to 90 wt% ethanol, extract at a temperature of 20 to 80°C for 30 to 90 minutes, repeat 1 to 3 times, combine the extracts, and recover the remaining ethanol Liquid I, the remaining liquid is absorbed by D101 macroporous resin column, eluted with 10%-90wt% ethanol at 10°C-40°C, the eluate is collected and the ethanol is separated to obtain the remaining liquid II, and the remaining liquid II is further dried to obtain the cassia seed extract thing;

Preparation of lotus leaf extract: crush the lotus leaf, add 10-90wt% ethanol of 5-15 times the mass, extract at 20-85°C for 30-90 minutes, repeat 1-3 times, combine the extracts, and recover ethanol The residual liquid I was obtained, and the residual liquid was adsorbed by a D101 macroporous resin column, eluted with 10% to 90wt% ethanol at 10°C to 40°C, the eluate was collected and the ethanol was separated to obtain the residual liquid II, and the residual liquid II was further dried to obtain lotus leaf extract;

Preparation of red yeast rice extract: add 10-90wt% ethanol of 5-15 times the mass to red yeast rice, extract at 20-80°C for 30-90 minutes, repeat 1-3 times, combine the extracts, recover Ethanol to obtain the residual solution I, the residual solution is absorbed by D101 macroporous resin column, and eluted with 10% to 90wt% ethanol at 10°C to 40°C, the eluate is collected and the ethanol is separated to obtain the residual liquid II, and the residual liquid II is further dried Red Yeast Rice Extract;

Preparation of kudzu root extract: add 5-15 times the mass of 10-90wt% ethanol to kudzu root, extract at 20-80°C for 30-90 minutes, repeat 1-3 times, combine extracts, recover ethanol to obtain residual liquid I, the remaining liquid is absorbed by a D101 macroporous resin column, eluted with 10% to 90 wt% ethanol at 10°C to 40°C, the eluate is collected and ethanol is separated to obtain the remaining liquid II, and the remaining liquid II is further dried to obtain the kudzu root extract .

Further preferably, the buckwheat extract, cassia seed extract, lotus leaf extract, red yeast extract, and kudzu root extract are extracted according to the following steps:

The preparation of buckwheat extract: take buckwheat flowers, leaves, seeds or rhizomes, add 10 times the mass of 70wt% ethanol, extract at a temperature of 60°C for 60 minutes, repeat 3 times, combine the extracts, reclaim the ethanol to obtain the remaining liquid I, the remaining The liquid is absorbed by a D101 macroporous resin column, eluted with 70wt% ethanol at 30°C, the eluate is collected and the ethanol is separated to obtain the residual liquid II, and the residual liquid II is further dried to obtain the buckwheat extract;

Preparation of cassia seed extract: crush cassia seed, add 15 times the mass of 80wt% ethanol, extract at 70°C for 60 minutes, repeat 3 times, combine the extracts, recover ethanol to obtain residual liquid I, and pass the residual liquid through D101 macroporous resin Column adsorption, eluting with 80wt% ethanol at 30°C, collecting the eluate and separating the ethanol to obtain the residual liquid II, and further drying the residual liquid II to obtain the cassia seed extract;

Preparation of lotus leaf extract: crush the lotus leaf, add 10 times the mass of 60wt% ethanol, extract at 65°C for 90 minutes, repeat 3 times, combine the extracts, recover the ethanol to obtain the remaining liquid I, and pass the remaining liquid through D101 Pore resin column adsorption, eluting with 65wt% ethanol at 30°C, collecting the eluate and separating the ethanol to obtain the residual liquid II, and further drying the residual liquid II to obtain the lotus leaf extract;

Preparation of red yeast rice extract: add 15 times the mass of 80wt% ethanol to red yeast rice, extract at 70°C for 90 minutes, repeat 3 times, combine the extracts, recover ethanol to obtain residual liquid I, and pass the residual liquid through D101 Adsorbed on a macroporous resin column, eluted with 80wt% ethanol at 30°C, collected the eluate and separated the ethanol to obtain the residual liquid II, and further dried the residual liquid II to obtain the red yeast rice extract;

Preparation of Pueraria root extract: Add 10 times the mass of 75wt% ethanol to Pueraria root, extract at 60°C for 60 minutes, repeat 3 times, combine the extracts, recover ethanol to obtain residual liquid I, and pass the residual liquid through D101 macroporous resin column Adsorbed, eluted with 70wt% ethanol at 30°C, collected the eluate and separated the ethanol to obtain the raffinate II, and further dried the raffinate II to obtain the kudzu root extract.

2. The preparation method of the lipid-lowering health food is characterized in that buckwheat extract, cassia seed extract, lotus leaf extract, red yeast rice extract, kudzu root extract, and raffinose are respectively pulverized into powders less than 120 mesh, Weigh the extracts and raffinose according to the proportion by weight, mix them evenly, granulate with 85% ethanol and a 20-mesh sieve, dry at 40°C, and pass the dry granules through a 10-mesh sieve for granulation; ultrafinely pulverize the flaxseed, and prepare according to the prescription The proportion by weight is weighed, mixed evenly with dry granules, and prepared into a dosage form suitable for oral administration by adopting a conventional preparation process of oral preparations.

Preferably, the dosage form is powder, granule, tablet, capsule or oral liquid.

The effect of each raw material used in the present invention is as follows:

(1) Buckwheat has high nutritional value and medicinal value, and has been planted as a crop for both medicine and food. Modern pharmacological studies have found that the lipid-lowering effect is related to the large amount of bioflavonoid rutin contained in buckwheat. Rutin can protect the insulin receptor substrate and adenylate-activated protein kinase signaling pathway of β-cell RIN-m5f, inhibit Liposynthetic enzyme activity, lower blood lipids and cholesterol. Buckwheat bran total flavonoids extract can significantly reduce serum TG (triglyceride), TC (serum total cholesterol) and liver TG, TC and other four indicators, thereby reducing blood cholesterol and the risk of heart disease.

(2) Semen Cassiae contains anthraquinone compounds and their derivatives, which can promote intestinal peristalsis, reduce the residence time of lipids in the intestinal tract, and reduce the absorption of TG and cholesterol in the intestinal tract. The phytosterols contained in cassia seeds have the effect of inhibiting the increase of total cholesterol level in the human body and the formation of atherosclerotic plaque. Semen Cassiae can also lower blood lipids by inhibiting the synthesis of cholesterol in cells.

(3) Lotus leaf alkaloids have a significant effect on the index of regulating triglyceride (TG) in blood lipids, and lotus leaf alkaloids have a non-competitive inhibitory effect on the inhibition of pancreatic lipase, thereby reducing the body's ability to hydrolyze and digest fat in the diet. absorb.

(4) Red yeast rice extract can not only lower cholesterol, but also have a preferential effect on lowering low-density cholesterol that causes arteriosclerosis. Red yeast rice contains a large amount of phytosterol-stigmasterol, which can competitively inhibit the body's absorption of cholesterol, effectively reduce serum cholesterol levels, and regulate blood lipid balance.

(5) Human experiments have shown that intake of raffinose can promote the proliferation of bifidobacteria, produce short-chain fatty acids, lower cholesterol, and improve lipid metabolism. Because the human body lacks the digestive enzyme α-D-galactosidase that decomposes raffinose, raffinose can directly reach the large intestine without being digested and absorbed, and is used by bifidobacteria. It is an effective growth factor for bifidobacteria.

(6) Flaxseed contains a large amount of unsaturated fatty acids, which can combine with cholesterol to form esters with low melting point, easy to transport, metabolize and excrete, change the distribution of cholesterol in the body, and reduce the deposition of lipid esters in the blood vessel wall.

(7) Puerarin, daidzin, daidzein, genistin and other isoflavones in kudzu root all have cardiovascular system pharmacological activities such as anti-myocardial ischemia, vasodilator and blood lipid lowering. Among them, puerarin can significantly reduce the content of total cholesterol in mouse serum, increase the content of high-density lipoprotein, reduce the content of low-density lipoprotein and very low-density lipoprotein, and prevent excessive oxidation of low-density lipoprotein. Puerarin reduces the deposition of fat on the coronary artery wall through the above effects, thereby reducing the incidence of atherosclerosis.

The beneficial effects of the present invention are: the present invention discloses a lipid-lowering health food and its preparation method, which uses the dialectical treatment theory of TCM for hyperlipidemia in formula design, embodies the overall and comprehensive concept of prevention and treatment, such as buckwheat It has the effects of strengthening the intestines and stomach, replenishing qi, and sustaining the spirit, and can effectively improve the "deficiency syndrome" of patients with hyperlipidemia; cassia seed is sweet, bitter, cold in nature, slightly salty, can clear the liver and kidney, improve eyesight, diuresis and laxative; Lotus leaf has the effect of clearing the wind and heat of the head, stopping dizziness and clearing phlegm; red yeast rice has the effect of promoting blood circulation and removing blood stasis, invigorating the spleen and eliminating food, and is mainly used to treat food stagnation and abdominal distension; kudzu root enters the spleen and stomach meridian to relieve spleen and stomach deficiency hot and thirsty. The combination of the above-mentioned medicinal materials can also treat "dampness, deficiency, and numbness" of hyperlipidemia, thereby exerting a synergistic effect. At the same time, it solves the problem that chemical drugs cause health damage to patients due to their serious side effects during treatment; avoids the need to take multiple drugs at the same time because patients with hyperlipidemia are often accompanied by other diseases. The interaction may affect the efficacy of the drug, as well as many possible adverse reactions and side effects.

detailed description

The present invention will be further described in detail below in conjunction with specific embodiments. It should be noted that the following specific examples are only preferred implementations of the present invention, and are not intended to limit the protection scope of the present invention. As long as there is no conflict, each embodiment in the present invention and each feature in each embodiment They can be combined with each other, and the formed technical solutions are all within the protection scope of the present invention.

Example 1

A lipid-lowering health food, comprising the following ingredients according to the mass ratio: 40 parts of buckwheat extract, 25 parts of cassia seed extract; 30 parts of lotus leaf extract; 30 parts of red yeast rice extract; 20 parts of kudzu root extract; flax 10 parts of superfine seed powder; 5 parts of raffinose.

The buckwheat extract, cassia seed extract, lotus leaf extract, red yeast rice extract, kudzu root extract are prepared as follows:

The preparation of buckwheat extract: take buckwheat flowers, leaves, seeds or rhizomes, add 10 times the mass of 70wt% ethanol, extract at a temperature of 60°C for 60 minutes, repeat 3 times, combine the extracts, reclaim the ethanol to obtain the remaining liquid I, the remaining The liquid is absorbed by a D101 macroporous resin column, eluted with 70wt% ethanol at 30°C, the eluate is collected and the ethanol is separated to obtain the residual liquid II, and the residual liquid II is further dried to obtain the buckwheat extract;

Preparation of cassia seed extract: crush cassia seed, add 15 times the mass of 80wt% ethanol, extract at 70°C for 60 minutes, repeat 3 times, combine the extracts, recover ethanol to obtain residual liquid I, and pass the residual liquid through D101 macroporous resin Column adsorption, eluting with 80wt% ethanol at 30°C, collecting the eluate and separating the ethanol to obtain the residual liquid II, and further drying the residual liquid II to obtain the cassia seed extract;

Preparation of lotus leaf extract: crush the lotus leaf, add 10 times the mass of 60wt% ethanol, extract at 65°C for 90 minutes, repeat 3 times, combine the extracts, recover the ethanol to obtain the remaining liquid I, and pass the remaining liquid through D101 Pore resin column adsorption, eluting with 65wt% ethanol at 30°C, collecting the eluate and separating the ethanol to obtain the residual liquid II, and further drying the residual liquid II to obtain the lotus leaf extract;

Preparation of red yeast rice extract: add 15 times the mass of 80wt% ethanol to red yeast rice, extract at 70°C for 90 minutes, repeat 3 times, combine the extracts, recover ethanol to obtain residual liquid I, and pass the residual liquid through D101 Adsorbed on a macroporous resin column, eluted with 80wt% ethanol at 30°C, collected the eluate and separated the ethanol to obtain the residual liquid II, and further dried the residual liquid II to obtain the red yeast rice extract;

Preparation of Pueraria root extract: Add 10 times the mass of 75wt% ethanol to Pueraria root, extract at 60°C for 60 minutes, repeat 3 times, combine the extracts, recover ethanol to obtain residual liquid I, and pass the residual liquid through D101 macroporous resin column Adsorbed, eluted with 70wt% ethanol at 30°C, collected the eluate and separated the ethanol to obtain the raffinate II, and further dried the raffinate II to obtain the kudzu root extract.

The preparation method of the lipid-lowering health food is as follows: respectively pulverize buckwheat extract, cassia seed extract, lotus leaf extract, red yeast rice extract, kudzu root extract, and raffinose into powders less than 120 meshes, and mix according to parts by weight Weigh each extract and raffinose, mix them evenly, granulate with 85% ethanol and a 20-mesh sieve, dry at 40°C, and pass the dry granules through a 10-mesh sieve for granulation; ultrafinely pulverize the flaxseed, and weigh it according to the weight of the prescription After taking it, mix it with dry granules evenly, and press it into tablets, each tablet weighs 1.0g.

Example 2

(1) Prescription ratio of lipid-lowering health food: 40 parts of buckwheat extract, 25 parts of cassia seed extract, 30 parts of lotus leaf extract, 30 parts of red yeast rice extract, 20 parts of kudzu root extract, 10 parts of flaxseed superfine powder 5 parts, 5 parts of marshmallow.

(2) Prepare each extract in the formula according to the extract preparation method in Example 1, pulverize the prepared extract and raffinose respectively, pass through a 120 mesh sieve, and weigh each extract and cottonseed by weight proportioning Sugar, mixed evenly, granulated with 85% ethanol, dried at 40°C, after the flaxseed was ultrafinely pulverized, the flaxseed superfine powder was weighed according to the prescription weight ratio, mixed evenly with the granules, granulated with 70% ethanol, 40 ℃ drying, 10-mesh sieve granulation, packaging, 3.0g per bag, named buckwheat lipid-lowering granules.

Application example

The buckwheat lipid-lowering granule prepared in Example 2 was carried out in an animal experiment of blood-lipid-lowering function

Select SPF grade male golden hamsters and randomly distribute them into 11 groups with 12 hamsters in each group. Set up a blank control group, a hyperlipidemia model group and a buckwheat Jiangzhi granule administration group (5 mg/kg, 10 mg/kg). The blank group was fed with common feed, and the rest of the experimental groups were fed with high-fat feed. After 4 weeks of continuous high-fat feed, the levels of TG and LDL in blood lipids were detected to determine whether the model was successful. After successful modeling, the blank control group and hyperlipidemia model group were given 1.0ml/piece of distilled water, respectively, and the buckwheat Jiangzhi granule administration group was given 5 mg/kg and 10 mg/kg for 4 weeks, during which they continued to be fed high-fat feed and basal feed , the positive control group was given XX capsules (10mg/kg), and the administration method was the same as that of the buckwheat granule group. 12 hours after the last administration in each group, blood was taken by decapitation, serum was separated, and triglyceride (TG) and low-density lipoprotein cholesterol (LDL) were detected. The result is as follows:

Each administration group of table 1 feeds with high-fat feed back the 4th week blood lipid component LDL, TG experimental result ( n=5)

Note: Compared with the blank group: ###P<0.001; compared with the model group: ###P<0.01

Table 2 Buckwheat Jiangzhi Granules for hyperlipidemia animal model LDL, TG effects ( n=7)

Note: Compared with the model group, *P<0.05, **P<0.01, **P<0.001

Compared with the normal group, ##P＜0.01, ###P＜0.001

It can be seen from Table 1 that after the animals were sacrificed at the fourth week, the levels of LDL and TG in the serum of the hyperlipidemia model group were significantly higher than those of the blank group (P<0.01), suggesting that the hyperlipidemia animal model was successfully established.

As can be seen from Table 1, after each administration group was executed at the eighth week, LDL and TG in the serum of the hyperlipidemia model group were significantly increased compared with the blank group (P<0.01), suggesting that the hyperlipidemia animal model established in this experiment has Very good stability. Compared with the model group, Buckwheat Jiangzhi Granules (10mg/kg) had a significant effect on blood lipid components TG and LDL (P<0.05). Compared with the positive control drug XX Capsules (10mg/kg), Buckwheat Jiangzhi Granules (10mg/kg kg) is superior to the contrast drug. Buckwheat Jiangzhi Granules (10mg/kg) has the effect of lowering TG and LDL, which is significantly different from that of the model group.

It can be seen from Table 1 and Table 2 that the animal model of hyperlipidemia in golden hamsters has been successfully established, and this model is more similar to hyperlipidemia caused by high-fat diet in humans. After the administration of buckwheat Jiangzhi granules, the preliminary experimental research results found that 10 mg/kg of buckwheat Jiangzhi granules has a certain blood lipid-lowering effect, and the lipid-lowering effect is better than that of XX capsules, suggesting that buckwheat Jiangzhi granules can improve hyperlipidemia.

Finally, it should be noted that the above preferred embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail through the above preferred embodiments, those skilled in the art should understand that it can be described in terms of form and Various changes may be made in the details without departing from the scope of the invention defined by the claims.

Claims (7)

1. a kind of lipid-lowering health food, it is characterised in that include following composition by proportion by weight：5~60 parts of buckwheat extract, 5~50 parts of cassia seed extract；5~50 parts of Lotus Leafextract；5~50 parts of red yeast rice rice extracts；5~30 parts of kudzu root extract； 1~30 part of linseed Ultramicro-powder；1~20 part of raffinose.

2. a kind of lipid-lowering health food according to claim 1, it is characterised in that include following composition by proportion by weight： 40 parts of buckwheat extract, 25 parts of cassia seed extract；30 parts of Lotus Leafextract；30 parts of red yeast rice rice extracts；Kudzu root extract 20 Part；10 parts of linseed Ultramicro-powder；5 parts of raffinose.

3. a kind of lipid-lowering health food according to claim 1, it is characterised in that the buckwheat extract is by sweet cherry roots or hardship Extracted in flower, leaf, seed, the rhizome of buckwheat and obtained, general flavone content is not less than 65.0% in buckwheat extract；The cassia seed Extract is extracted by cassia seed and obtained, and total anthrone content is not less than 50.0% in cassia seed extract；Lotus Leafextract is by lotus Leaf is extracted and obtained, and total alkaloid content is not less than 50.0% in Lotus Leafextract；Red yeast rice rice extracts are extracted by red yeast rice Arrive, content of phytosterol is not less than 30.0% in red yeast rice rice extracts；Kudzu root extract is to be extracted to obtain by the root of kudzu vine, and the root of kudzu vine is extracted Puerarin content is not less than 30.0% in thing.

4. a kind of lipid-lowering health food according to claim 1, it is characterised in that the buckwheat extract, cassia seed are extracted Thing, Lotus Leafextract, Red Yeast Rice P.E, kudzu root extract are extracted as follows：

The preparation of buckwheat extract：Buckwheat Flower, leaf, seed or rhizome are taken, 5~15 times of 10~90wt% ethanol of quality are added, Extracted 30~90 minutes at a temperature of 20~80 DEG C, repeated 1~3 time, merge extract solution, reclaimed ethanol and obtain extraction raffinate I, extraction raffinate passes through D101 macroporous resin columns are adsorbed, and with 10 DEG C~40 DEG C of 10%~90wt% ethanol wash-out, are collected eluent and are isolated ethanol and obtain Extraction raffinate II, buckwheat extract is further dried to obtain by extraction raffinate II；

The preparation of cassia seed extract：Cassia seed is crushed, 5~15 times of 10~90wt% ethanol of quality is added, 20~80 Extracted 30~90 minutes at a temperature of DEG C, repeated 1~3 time, merge extract solution, reclaimed ethanol and obtain extraction raffinate I, extraction raffinate passes through D101 macropores Resin column is adsorbed, and with 10 DEG C~40 DEG C of 10%~90wt% ethanol wash-out, is collected eluent and is isolated ethanol and obtain extraction raffinate II, will Extraction raffinate II is further dried to obtain cassia seed extract；

The preparation of Lotus Leafextract：Lotus leaf is crushed, 5~15 times of 10~90wt% ethanol of quality is added, in 20~85 DEG C of temperature Degree is lower to be extracted 30~90 minutes, is repeated 1~3 time, merges extract solution, is reclaimed ethanol and is obtained extraction raffinate I, and extraction raffinate passes through D101 macroreticular resins Post is adsorbed, and with 10 DEG C~40 DEG C of 10%~90wt% ethanol wash-out, is collected eluent and is isolated ethanol and obtain extraction raffinate II, by extraction raffinate II is further dried to obtain Lotus Leafextract；

The preparation of red yeast rice rice extracts：5~15 times of 10~90wt% ethanol of quality are added in red yeast rice, in 20~80 DEG C of temperature Degree is lower to be extracted 30~90 minutes, is repeated 1~3 time, merges extract solution, is reclaimed ethanol and is obtained extraction raffinate I, and extraction raffinate passes through D101 macroreticular resins Post is adsorbed, and with 10 DEG C~40 DEG C of 10%~90wt% ethanol wash-out, is collected eluent and is isolated ethanol and obtain extraction raffinate II, by extraction raffinate II is further dried to obtain red yeast rice rice extracts；

The preparation of kudzu root extract：5~15 times of 10~90wt% ethanol of quality are added in the root of kudzu vine, at a temperature of 20~80 DEG C Extract 30~90 minutes, repeat 1~3 time, merge extract solution, reclaim ethanol and obtain extraction raffinate I, extraction raffinate is inhaled by D101 macroporous resin columns It is attached, with 10 DEG C~40 DEG C of 10%~90wt% ethanol wash-out, collect eluent and isolate ethanol and obtain extraction raffinate II, extraction raffinate II is entered One step it is dry kudzu root extract.

5. a kind of lipid-lowering health food according to claim 1, it is characterised in that the buckwheat extract, cassia seed are extracted Thing, Lotus Leafextract, Red Yeast Rice P.E, kudzu root extract are extracted as follows：

The preparation of buckwheat extract：Buckwheat Flower, leaf, seed or rhizome are taken, 10 times of 70wt% ethanol of quality is added, in 60 DEG C of temperature Degree is lower to be extracted 60 minutes, is repeated 3 times, and merges extract solution, is reclaimed ethanol and is obtained extraction raffinate I, and extraction raffinate is adsorbed by D101 macroporous resin columns, With 30 DEG C of 70wt% ethanol wash-out, collect eluent and isolate ethanol and obtain extraction raffinate II, extraction raffinate II is further dried to obtain buckwheat Extract；

The preparation of cassia seed extract：Cassia seed is crushed, 15 times of 80wt% ethanol of quality are added, extracted at a temperature of 70 DEG C 60 minutes, it is repeated 3 times, merges extract solution, reclaim ethanol and obtain extraction raffinate I, extraction raffinate is adsorbed by D101 macroporous resin columns, uses 80wt% 30 DEG C of ethanol wash-out, collects eluent and isolates ethanol and obtain extraction raffinate II, and extraction raffinate II is further dried to obtain into cassia seed extract； The preparation of Lotus Leafextract：Lotus leaf is crushed, 10 times of 60wt% ethanol of quality are added, extracted 90 minutes at a temperature of 65 DEG C, It is repeated 3 times, merges extract solution, reclaim ethanol and obtain extraction raffinate I, extraction raffinate is adsorbed by D101 macroporous resin columns, with 65wt% ethanol 30 DEG C wash-out, collects eluent and isolates ethanol and obtain extraction raffinate II, and extraction raffinate II is further dried to obtain into Lotus Leafextract；

The preparation of red yeast rice rice extracts：15 times of 80wt% ethanol of quality are added in red yeast rice, 90 are extracted at a temperature of 70 DEG C Minute, it is repeated 3 times, merge extract solution, reclaim ethanol and obtain extraction raffinate I, extraction raffinate is adsorbed by D101 macroporous resin columns, uses 80wt% second 30 DEG C of alcohol wash-out, collects eluent and isolates ethanol and obtain extraction raffinate II, and extraction raffinate II is further dried to obtain into red yeast rice rice extracts；

The preparation of kudzu root extract：10 times of 75wt% ethanol of quality are added in the root of kudzu vine, are extracted 60 minutes at a temperature of 60 DEG C, It is repeated 3 times, merges extract solution, reclaim ethanol and obtain extraction raffinate I, extraction raffinate is adsorbed by D101 macroporous resin columns, with 70wt% ethanol 30 DEG C wash-out, collects eluent and isolates ethanol and obtain extraction raffinate II, and extraction raffinate II is further dried to obtain into kudzu root extract.

6. the preparation method of lipid-lowering health food described in any one of Claims 1 to 5, it is characterised in that by buckwheat extract, certainly Pine torch extract, Lotus Leafextract, red yeast rice rice extracts, kudzu root extract, raffinose are crushed to the powder less than 120 mesh respectively End, weighs each extract and raffinose by weight ratio, is well mixed, and is pelletized with 85% ethanol, 20 mesh sieves, 40 DEG C of dryings, Dry particl crosses 10 mesh sieve whole grains；By linseed ultramicro grinding, it is well mixed with dry particl after being weighed by prescription weight, is adopted It is made of the preparation technology of traditional oral preparation and is suitable to oral formulation.

7. the preparation method of lipid-lowering health food according to claim 6, it is characterised in that the formulation is powder, particle Agent, tablet, capsule or oral liquid.