CN105873909A - Substituted [1,2,4]triazole and imidazole compounds - Google Patents

Substituted [1,2,4]triazole and imidazole compounds Download PDF

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Publication number
CN105873909A
CN105873909A CN201480066682.4A CN201480066682A CN105873909A CN 105873909 A CN105873909 A CN 105873909A CN 201480066682 A CN201480066682 A CN 201480066682A CN 105873909 A CN105873909 A CN 105873909A
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compound
alkyl
row
implication
group
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Inventor
W·格拉梅诺斯
N·布戴
B·米勒
M·A·昆泰罗帕洛玛
A·埃斯克里巴诺奎斯塔
E·M·W·劳特瓦瑟尔
J·K·洛曼
T·格洛特
M·克雷奇默
I·R·克雷格
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BASF SE
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BASF SE
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Priority claimed from PCT/EP2013/076315 external-priority patent/WO2014095548A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom

Abstract

The present invention relates to compoundsof the formula (I) and the N-oxides and the salts there off or combating phytopathogenic fungi, and to the use and methods for combating phytopathogenic fungi and to seeds coated with at least one such compound. The invention also relates to processes for preparing these compounds, intermediates, processes for preparing such intermediates, and to compositions comprising at least one compound I.

Description

Substituted [1,2,4] triazole and imidazolium compounds
The present invention relates to substituted [1,2,4] triazole for preventing and treating plant pathogenic fungi and imidazoles chemical combination Thing and N-oxide thereof and salt, purposes and the method relating to preventing and treating plant pathogenic fungi and scribble to The seed of few this compound a kind of.The invention still further relates to prepare the method for these compounds, intermediate, Prepare the method for such intermediate and comprise the compositions of at least one compound I.
DE 3430833 relates to α-(ethynyl phenyl)-α-alkyl-1H-azoles-1-ethanol and as antifungal The purposes of agent.WO 2013/007767 relates to replacement 1-[4-phenoxy group-2-(haloalkyl) benzene of antifungal Base]-2-(1,2,4-triazol-1-yl) alcohol cpd.At Pestic.Sci.1995, beg in 44,183-195 Some commercially available triazole antifungal agents such as cyproconazole (cyproconazole) and Tebuconazole are discussed (tebuconazole) chemical constitution and its biologic activity to Botrytis cinerea (Botrytis cinerea) Mutual relation.
In many cases, especially under low rate of application, it is known that the antifungal of Fungicidal compounds is lived Property is the most unsatisfactory.Based on this, the invention aims to provide phytopathogenic harmful fungi There is the compound improving active and/or wider activity profile.
Surprisingly, this purpose has favourable Fungicidally active by using to plant pathogenic fungi Substituted [1,2,4] triazole of formula I and imidazolium compounds realize.
Therefore, the present invention relates to compound of formula I and N-oxide thereof and can agricultural salt:
Wherein
A is CH or N；
R1For C1-C6Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C3-C6Cycloalkyl；
Wherein R1Aliphatic moiety be not further substituted or can with 1,2,3 or at most maximum Can number be independently selected from following identical or different group R1a:
R1aHalogen, OH, CN, C1-C4Alkoxyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl And C1-C4Halogenated alkoxy；
Wherein R1Cyclic alkyl moiety be not further substituted or with 1,2,3,4,5 or extremely The most the maximum number of it is independently selected from following identical or different group R1b:
R1bHalogen, OH, CN, C1-C4Alkyl, C1-C4Alkoxyl, C1-C4Haloalkyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl and C1-C4Halogenated alkoxy；
R2For hydrogen, C1-C4Alkyl, C2-C4Alkenyl, C2-C4Alkynyl；
Wherein R2Aliphatic moiety be not further substituted or can with 1,2,3 or at most maximum Can number be independently selected from following identical or different group R2a:
R2aHalogen, OH, CN, C1-C4Alkoxyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl And C1-C4Halogenated alkoxy；
R3Selected from hydrogen, halogen, CN, C1-C4Alkyl, C1-C4Alkoxyl, C2-C4Alkenyl, C2-C4 Alkynyl, C3-C6Cycloalkyl, S (O)p(C1-C4Alkyl), wherein R3The most unsubstituted or quilt 1,2,3 or 4 R3aIt is further substituted with；Wherein
R3aIndependently selected from halogen, CN, OH, C1-C4Alkyl, C1-C4Haloalkyl, C3-C6Ring Alkyl, C3-C6Halogenated cycloalkyl, C1-C4Alkoxyl and C1-C4Halogenated alkoxy；
Z is C3-C8Cycloalkyl or C3-C8Cycloalkenyl group, wherein cycloalkyl or cycloalkenyl group unsubstituted (m=0) or By (R4)mReplace；Wherein
M is 0,1,2,3 or 4；With
R4In each case independently selected from halogen, CN, NO2、OH、SH、C1-C6Alkyl, C1-C6Alkoxyl, C2-C6Alkenyl, C2-C6Alkynyl, C3-C6Cycloalkyl, C3-C6Cycloalkanes Epoxide, S (O)p(C1-C4Alkyl), C (=O) (C1-C4Alkyl), C (=O) (OH), C (=O) (O-C1-C4Alkyl), C (=O) (NH (C1-C4Alkyl)), C (=O) (N (C1-C4Alkane Base)2)；Wherein R4The most unsubstituted or by 1,2,3 or 4 R4aIt is further substituted with, Wherein
R4aIndependently selected from halogen, CN, NO2、OH、C1-C4Alkyl, C1-C4Haloalkyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl, C1-C4Alkoxyl and C1-C4Haloalkoxy Base；
P is 0,1 or 2.
Compound I can use transition metal-catalyzed solvent (such as THF, DMF, MeCN, NEt3、Et(iPr2) N, pyrrolidine, piperidines, pyridine, diethylamine) in use alkali (such as NEt3、Et(iPr2)N、 Pyrrolidine, piperidines, pyridine, diethylamine) and suitable catalyst such as Pd, Cu, Pt, Rh, Ir, Al、Li、Pd(PPh3)4、PdCl2(PPh3)2、PdCl2(dppf)、CuI、CuBr、CuCl、LiCl、 AlCl3Or its mixture by halogenated compound II prepare (such as see Tetrahedron:Asymmetry, 18 (17), 2086-2090；2007；Angewandte Chemie, International Edition, 43 (29), 3814-3818；2004；Medicinal Chemistry, 53 (3), 994-1003； 2010；Organometallics, 25 (24), 5768-5773；2006).
Wherein R2The compound I for hydrogen can be by not making alcoholic compound I (R2=H) and R2-LG is preferred In the presence of a base reaction and obtained by this alcoholic compound, wherein represent can the leaving group of nucleophilic displacement for LG Group such as halogen, alkyl sulphonyl, alkylsulfonyloxy and aryl-sulfonyl oxygen, preferably chlorine, bromine or iodine, Particularly preferably bromine.X、Y、R2、R3、R4, n and m as defined herein.
Halogenated compound II can be prepared by known molecular.Such as, substituted phenyl lattice profit is produced Refined and convert it into ketone IV (being similar to the compound such as in WO 2013/07767).Epoxidation And react with triazole subsequently and obtain halogenated compound II.
Hal=halogen, such as Br
Or, compound II can be prepared according to following scheme.
Produce grignard and use chlorinating agent (such as SO2Cl2、NCS、Cl2) the so obtained acyl of chlorination Based compound IVa.Add metallorganic matter (such as Grignard compound) and obtain chlorhydrin IIIa, with After convert it into halogenated compound II.
N-oxide can be prepared according to conventional oxidation method by the compounds of this invention, such as by with having Machine peracid such as metachloroperbenzoic acid (see WO 03/64572 or J.Med.Chem.38 (11), 1892-903,1995)；Or (see J.Heterocyc.Chem. with inorganic oxidizer such as hydrogen peroxide 18 (7), 1305-8,1981) or oxone (see J.Am.Chem.Soc.123 (25), 5962-5973,2001) process compound I.Oxidation is likely to be obtained pure list-N-oxide or different N- Hopcalite, the latter can pass through conventional method such as chromatography.
If synthesis obtains isomer mixture, the most generally not necessarily require separation, because in some situation Lower Isomers may be (such as in light, acid in the last handling process in order to apply or in application Or under the effect of alkali) mutually convert.Such conversion can also occur, such as after a procedure in plant treatment In the case of in processed plant or in harmful fungoid to be prevented and treated.
Midbody compound discussed further below.Those of skill in the art this paper easy to understand just changes The preferred situation of the given substituent group of compound I, especially also has and is given those to corresponding substituent group in the following table, Correspondingly apply to intermediate.Therefore, substituent group is the most independently of each other or more preferably Combination has implication defined herein.
N-oxide can be prepared according to conventional oxidation method by the compounds of this invention, such as by with having Machine peracid such as metachloroperbenzoic acid (see WO 03/64572 or J.Med.Chem.38 (11), 1892-903,1995)；Or (see J.Heterocyc.Chem. with inorganic oxidizer such as hydrogen peroxide 18 (7), 1305-8,1981) or oxone (see J.Am.Chem.Soc.123 (25), 5962-5973,2001) process compound I.Oxidation is likely to be obtained pure list-N-oxide or different N- Hopcalite, the latter can pass through conventional method such as chromatography.
If synthesis obtains isomer mixture, the most generally not necessarily require separation, because in some situation Lower Isomers may be (such as in light, acid in the last handling process in order to apply or in application Or under the effect of alkali) mutually convert.Such conversion can also occur, such as after a procedure in plant treatment In the case of in processed plant or in harmful fungoid to be prevented and treated.
Midbody compound discussed further below.Those of skill in the art this paper easy to understand just changes The preferred situation of the given substituent group of compound I, especially also has and is given those to corresponding substituent group in the following table, Correspondingly apply to intermediate.Therefore, substituent group is the most independently of each other or more preferably Combination has implication defined herein.
Formula V compound is at least partly new.Therefore, another embodiment of the present invention is Formula V Compound (sees above), and the most each variable such as herein for Formula I is defined and institute's preferred definition.
Formula IV compound is at least partly new.Therefore, another embodiment of the present invention is formula IV Compound (sees above), and the most each variable such as herein for Formula I is defined and institute's preferred definition.
Formula IV a compound is at least partly new.Therefore, another embodiment of the present invention is formula IV a Compound (sees above), and the most each variable such as herein for Formula I is defined and institute's preferred definition.
Formula III compound is at least partly new.Therefore, another embodiment of the present invention is formula III Compound (sees above), and the most each variable such as herein for Formula I is defined and institute's preferred definition.
Formula III a compound is at least partly new.Therefore, another embodiment of the present invention is formula III a Compound (sees above), and the most each variable such as herein for Formula I is defined and institute's preferred definition.
Formula II compound is at least partly new.Therefore, another embodiment of the present invention is Formula II Compound (sees above), and the most each variable such as herein for Formula I is defined and institute's preferred definition.
Formula II a compound is at least partly new.Therefore, another embodiment of the present invention is Formula II a Compound (sees above), and the most each variable such as herein for Formula I is defined and institute's preferred definition.
In the definition of variable given above, use the collectivity art of the usually representative of described substituent group Language.Term " Cn-Cm" represent every kind in the case of can in described substituent group or substituent structure part The carbon number of energy.
Term " halogen " relates to fluorine, chlorine, bromine and iodine.
Term " C1-C6Alkyl " relate to straight chain or branched saturated hydrocarbyl, the example with 1-6 carbon atom Such as methyl, ethyl, propyl group, 1-Methylethyl, butyl, 1-methyl-propyl, 2-methyl-propyl, 1,1- Dimethyl ethyl, amyl group, 1-methyl butyl, 2-methyl butyl, 3-methyl butyl, 2,2-dimethyl propylene Base, 1-ethyl propyl, 1,1-dimethyl propyl, 1,2-dimethyl propyl, hexyl, 1-methyl amyl, 2-methyl amyl, 3-methyl amyl, 4-methyl amyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-second Base butyl, 2-ethyl-butyl, 1,1,2-thmethylpropyl, 1,2,2-thmethylpropyl, 1-ethyl-1-methyl Propyl group and 1-Ethyl-2-Methyl propyl group.Equally, term " C2-C4Alkyl " relate to that there is 2-4 carbon The straight chain of atom or branched-alkyl, such as ethyl, propyl group (n-pro-pyl), 1-Methylethyl (isopropyl), fourth Base, 1-methyl-propyl (sec-butyl), 2-methyl-propyl (isobutyl group), 1,1-dimethyl ethyl (tert-butyl group).
Term " C1-C6Haloalkyl " relate to the alkyl as defined above with 1 or 6 carbon atom, Wherein the some or all hydrogen atoms in these groups can be substituted by halogen atom as above.Example It is " C1-C2Haloalkyl " as chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, methyl fluoride, Difluoromethyl, trifluoromethyl, chlorine methyl fluoride, dichloro one methyl fluoride, a chlorodifluoramethyl-, 1-chloroethene Base, 1-bromoethyl, 1-fluoro ethyl, 2-fluoro ethyl, 2,2-bis-fluoro ethyl, 2,2,2-trifluoroethyl, 2-chlorine -2-fluoro ethyl, 2-chloro-2,2-bis-fluoro ethyl, 2,2-bis-chloro-2-fluoro ethyl, 2,2,2-trichloroethyl or five fluorine Ethyl.
Term " C1-C6Hydroxy alkyl " relate to the alkyl as defined above with 1 or 6 carbon atom, Wherein the some or all hydrogen atoms in these groups can be substituted by OH group.
Term " C2-C6Alkenyl " relate to having the straight of 2-6 carbon atom and double bond at an arbitrary position Chain or branched unsaturated alkyl.Example is " C2-C4Alkenyl ", such as vinyl, 1-acrylic, 2- Acrylic (pi-allyl), 1-methyl ethylene, 1-butylene base, crotyl, 3-cyclobutenyl, 1-methyl -1-acrylic, 2-methyl-1-propylene base, 1-methyl-2-acrylic, 2-methyl-2-acrylic.
Term " C2-C6Alkynyl " relate to that there is 2-6 carbon atom and the straight chain containing at least one three key Or branched unsaturated alkyl.Example is " C2-C4Alkynyl ", such as acetenyl, acrylate-1-alkynyl, acrylate-2- Alkynyl (propargyl), butyl-1-alkynyl, butyl-2-alkynyl, butyl-3-alkynyl, 1-methyl Propargyl.
Term " C3-C6Cycloalkyl " relate to the monocyclic saturated hydrocarbon group base with 3-6 carbon ring member, such as ring Propyl group, cyclobutyl, cyclopenta, cyclohexyl.
Term " C3-C6Cycloalkenyl group " relate to having the monocycle of 3-6 carbon ring member and at least one double bond Unsaturated 3,4, the 5 or 6 Yuans carbocyclic rings of part, such as cyclopentenyl, cyclopentadienyl group, cyclohexadienyl.
Term " C3-C8Cycloalkyl-C1-C4Alkyl " relate to there is the alkyl of 1-4 carbon atom (as above Defined), wherein a hydrogen atom of alkyl is had the cycloalkyl of 3-8 carbon atom (as defined above) Substitute.
Term " C1-C6Alkoxyl " relate to via oxygen in alkyl optional position bonding there is 1-6 The straight chain of individual carbon atom or branched-alkyl.Example is " C1-C4Alkoxyl ", such as methoxyl group, ethoxy Base, positive propoxy, 1-methyl ethoxy, butoxy, 1-methyl-prop epoxide, 2-methyl-prop epoxide or 1,1-dimethylethyloxy.
Term " C1-C6Halogenated alkoxy " relate to C as defined above1-C6Alkoxyl, wherein at this Some or all hydrogen atoms in a little groups can be substituted by halogen atom as above.Example is “C1-C4Halogenated alkoxy ", such as OCH2F、OCHF2、OCF3、OCH2Cl、OCHCl2、 OCCl3, chlorine fluorine methoxyl group, dichloro one fluorine methoxyl group, a chlorine difluoro-methoxy, 2-fluorine ethyoxyl, 2-chloroethoxy, 2-bromine oxethyl, 2-iodine ethyoxyl, 2,2-difluoroethoxy, 2,2,2-trifluoro ethoxy, 2-chloro-2-fluorine ethyoxyl, 2-chloro-2,2-difluoroethoxy, 2,2-bis-chloro-2-fluorine ethyoxyl, 2,2,2-trichlorine Ethyoxyl, OC2F5, 2-fluorine propoxyl group, 3-fluorine propoxyl group, 2,2-difluoro propoxyl group, 2,3-difluoro third Epoxide, 2-chlorine propoxyl group, 3-chlorine propoxyl group, 2,3-compound, 2-bromine propoxyl group, 3-bromine the third oxygen Base, 3,3,3-trifluoropropyl epoxide, 3,3,3-trichlorine propoxyl group, OCH2-C2F5、OCF2-C2F5, 1-fluorine Methyl-2-fluorine ethyoxyl, 1-chloromethyl-2-chloroethoxy, 1-bromomethyl-2-bromine oxethyl, 4-fluorine fourth oxygen Base, 4-neoprene epoxide, 4-bromine butoxy or nine fluorine butoxy.
Term " C1-C4Alkoxy-C1-C4Alkyl " relate to there is the alkyl of 1-4 carbon atom (as above Defined), wherein a hydrogen atom of alkyl is by C1-C4Alkoxyl (as defined above) substitutes.Equally, Term " C1-C6Alkoxy-C1-C4Alkyl " alkyl that relates to having 1-4 carbon atom (as above determined Justice), wherein a hydrogen atom of alkyl is by C1-C6Alkoxyl (as defined above) substitutes.
Terms used herein " C1-C6Alkylthio group " relate to via sulfur atom linkage to have 1-6 carbon former The straight chain of son or branched-alkyl (as defined above).Therefore, terms used herein " C1-C6Alkyl halide sulfur Base " relate to, by sulphur atom optional position bonding in haloalkyl, there is 1-6 carbon atom Straight chain or branched halogenoalkyl (as defined above).
Term " C1-C6Alkyl sulphinyl " relate to passing through-S (=O)-structure division appointing in alkyl The straight chain with 1-6 carbon atom of meaning position bonding or branched-alkyl (as defined above), such as methyl Sulfinyl and ethylsulfinyl etc..Therefore, term " C1-C6Alkylsulfinyl " relate to And pass through-S (=O)-structure division in haloalkyl optional position bonding there is 1-6 carbon atom Straight chain or branched halogenoalkyl (as defined above).
Term " C1-C6Alkyl sulphonyl " relate to passing through-S (=O)2Any in alkyl of-structure division The straight chain with 1-6 carbon atom of position bonding or branched-alkyl (as defined above), such as methyl sulphur Acyl group and ethylsulfonyl etc..Therefore, term " C1-C6Halogenated alkyl sulfonyl " relate to passing through-S (=O)2- The straight chain with 1-6 carbon atom or branched of structure division optional position bonding in haloalkyl Haloalkyl (as defined above).
Term " C3-C8Cycloalkyl-C3-C8Cycloalkyl " relate to having 3-8 carbon atom cycloalkyl (as Upper defined), it is had another cycloalkyl substituted of 3-8 carbon atom.
Term " C3-C8Cycloalkyloxy " relate to the cycloalkyl with 3-8 carbon atom via oxygen bonding (as defined above).
Term " C (=O)-C1-C4Alkyl " relate to as shown in the valence mumber of carbon atom by group C (=O) Carbon atom connect group.The valence mumber of carbon is 4, and the valence mumber of nitrogen is 3.Should be also understood that following term: NH(C1-C4Alkyl), N (C1-C4Alkyl)2、NH(C3-C6Cycloalkyl), N (C3-C6Cycloalkyl)2、 C (=O) OH, C (=O)-O-C1-C4Alkyl, C (=O)-NH (C1-C4Alkyl), C (=O)-N (C1-C4 Alkyl)2, C (=O)-NH (C3-C6Cycloalkyl), C (=O)-N (C3-C6Cycloalkyl)2。
The compounds of this invention can especially include that its cation and anion are respectively to described chemical combination by agricultural salt The salt of those cationes that the fungicidal action of thing not adversely affects or the acid-addition salts of those acid.Properly Cation the most especially alkali metal ion, preferably sodium and the ion of potassium, alkaline-earth metal ions, preferably The ion of calcium, magnesium and barium, transition metal ions, preferably the ion of manganese, copper, zinc and ferrum, also there is a need to If can be with 1-4 C1-C4Alkyl substituent and/or a phenyl or the ammonium ion of benzyl substituent, Preferably diisopropyl ammonium, tetramethyl-ammonium, TBuA, tri methyl benzyl ammonium, in addition withIon, Sulfonium cation, preferably three (C1-C4Alkyl) sulfonium, and sulfoxonium, preferably three (C1-C4Alkyl) oxidation Sulfonium.The anion of useful acid-addition salts is mainly chloride ion, bromide ion, fluorion, bisulfate ion, sulfur Acid group, dihydrogen phosphate, hydrogen phosphate, phosphate radical, nitrate anion, bicarbonate radical, carbonate, hexafluoro Silicate, hexafluoro-phosphate radical, benzoate anion and C1-C4The anion of alkanoic acid, preferably formate, Acetate, propionate and butanoic acid root.They can be by making such the compounds of this invention and respective anionic Acid, preferably hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid or nitric acid reaction and formed.
The compounds of this invention can turn different with the resistance occurred by the singly-bound blocked rotation around asymmetric group Structure body exists.They also form a part for present subject matter.
Depend on that replacement mode, compound of formula I and N-oxide thereof can have one or more chirality Center, now they as pure enantiomer or pure diastereomer or mix as enantiomer or diastereomer Compound exists.Pure enantiomer or diastereomer and mixture thereof are both at present subject matter.
It is described below the particular of the compounds of this invention.It is described in further detail phase in this article Answering the concrete meaning of substituent group, wherein these implications the most individually but are also appointed with mutual Meaning is combined as the particular of the present invention.
Additionally, for each variable, the embodiment of compound I is generally also applied to intermediate.
A is N or CH according to the present invention.According to an embodiment, A is N.Real according to another Executing scheme, A is CH.
R1It is C according to the present invention1-C6Alkyl, C2-C6Alkenyl, C2-C6Alkynyl or C3-C6Cycloalkanes Base；Wherein R1Aliphatic moiety be not further substituted or with 1,2,3 or Greatly may number be independently selected from R1aHalogen, OH, CN, C1-C4Alkoxyl, C3-C8 Cycloalkyl, C3-C8Halogenated cycloalkyl and C1-C4The identical or different group R of halogenated alkoxy1a；And And wherein R1Cyclic alkyl moiety be not further substituted or with 1,2,3,4,5 or The most the maximum number of it is independently selected from halogen, OH, CN, C1-C4Alkyl, C1-C4Alcoxyl Base, C1-C4Haloalkyl, C3-C8Cycloalkyl, C3-C8Halogenated cycloalkyl and C1-C4Haloalkoxy The identical or different group R of base1b。
According to another embodiment of the present invention, R1Selected from C1-C6Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C3-C6Cycloalkyl and C3-C6Cycloalkyl-C1-C4Alkyl, wherein R1Every kind of situation Under unsubstituted or by as defined herein with the R of institute's preferred definition1aAnd/or R1bReplace.It is concrete Embodiment can find in following table P1.
According to a particular, R1For C1-C6Alkyl, especially C1-C4Alkyl, such as CH3、 C2H5、CH(CH3)2Or C (CH3)3.Another embodiment relates to following compound, wherein R1For By 1,2 or 3 or at most most probable number MPN purpose as defined herein with the identical of institute preferred definition or Different group R1aSubstituted C1-C6Alkyl, especially C1-C4Alkyl.According to its specific embodiments, R1For C1-C6Haloalkyl, especially C1-C4Haloalkyl, more specifically C1-C2Haloalkyl, Such as CF3Or CHF2.According to another its specific embodiments, R1For C1-C4Alkoxy-C1-C6Alkane Base, especially C1-C4Alkoxy-C1-C4Alkyl, such as CH2-OCH3.Its other being embodied as Scheme can find in following table P1.
According to still another embodiment, R1For C3-C8Cycloalkyl-C1-C6Alkyl, especially C3-C6Ring Alkyl-C1-C4Alkyl.Another embodiment relates to following compound, wherein R1For in alkyl structure portion By 1,2 or 3 or at most most probable number MPN purpose identical or different group R in Fen1aReplace and/or In cyclic alkyl moiety identical or different by 1,2,3,4 or 5 or at most most probable number MPN purpose Group R1bSubstituted C3-C8Cycloalkyl-C1-C6Alkyl, especially C3-C6Cycloalkyl-C1-C4Alkyl. R1aThe most as defined herein with institute's preferred definition.Its specific embodiments can be in following table P1 finds.
According to another embodiment, R1For C2-C6Alkenyl, especially C2-C4Alkenyl, as CH=CH2、CH2CH=CH2, CH=CHCH3Or C (CH3)=CH2.Another embodiment relates to Following compound, wherein R1For by 1,2 or 3 or at most most probable number MPN purpose is as defined herein Identical or different group R with institute's preferred definition1aSubstituted C2-C6Alkenyl, especially C2-C4Chain Thiazolinyl.According to its specific embodiments, R1For C2-C6Halogenated alkenyl, especially C2-C4Halo chain Thiazolinyl.Its other specific embodiments can find in following table P1.
According to still another embodiment, R1For C2-C6Alkynyl, especially C2-C4Alkynyl, as C ≡ CH, C≡CCH3、CH2-C ≡ C-H or CH2-C≡C-CH3。
Another embodiment relates to following compound, wherein R1For can by 1,2 or 3 or at most maximum Can number as defined herein with the identical or different group R of institute's preferred definition1aSubstituted C2-C6Alkynes Base, especially C2-C4Alkynyl.According to its specific embodiments, R1For C2-C6Halo alkynyl, especially It is C2-C4Halo alkynyl.According to its another specific embodiments, R1For C3-C6Cycloalkyl-C2-C6Alkynes Base or C3-C6Halogenated cycloalkyl-C2-C6Alkynyl, especially C3-C6Cycloalkyl-C2-C4Alkynyl or C3-C6 Halogenated cycloalkyl-C2-C4Alkynyl.Its other specific embodiments can find in following table P1.
According to still another embodiment, R1For C3-C6Cycloalkyl, such as C3H5(cyclopropyl), C4H7(ring fourth Base), cyclopenta or cyclohexyl.Another embodiment relates to following compound, wherein R1For by 1,2, 3,4 or 5 or at most most probable number MPN purpose as defined herein with the identical of institute preferred definition or not With group R1bSubstituted C3-C6Cycloalkyl, such as C3H5(cyclopropyl) or C4H7(cyclobutyl).According to it Specific embodiments, R1For C3-C6Halogenated cycloalkyl, such as halogenated cyclopropyl, especially 1-F-cyclopropyl Or 1-Cl-cyclopropyl.According to its another specific embodiments, R1For C3-C6Cycloalkyl-C3-C6Cycloalkanes Base, wherein said cycloalkyl-cyclic alkyl moiety is the most unsubstituted or with 1,2 or 3 such as R with institute's preferred definition defined herein1b, such as 1-cyclopropyl-cyclopropyl or 2-cyclopropyl-cyclopropyl. Its specific embodiments can find in following table P1.
Specifically, it may be preferred to R1Selected from C1-C4Alkyl, as methyl, ethyl, positive third Base, isopropyl, the tert-butyl group, CH2C(CH3)3And CH2CH(CH3)2, C1-C4Haloalkyl, as CF3, C2-C6Alkenyl, C2-C6Alkynyl, such as C ≡ CCH3, and C3-C6Cycloalkyl, such as ring Propyl group.
R1Particularly preferred embodiment according to the present invention in following table P1, wherein P1-1 is extremely Each row of P1-139 row is corresponding to particular, wherein a P1-1 to P1-139 of the present invention Also it is combined as the preferred embodiments of the invention with any.
Table P1:
R1aFor R1The possible substituent group of aliphatic moiety.
R1aIndividually in accordance with the invention selected from halogen, OH, CN, C1-C4Alkoxyl, C3-C6Ring Alkyl, C3-C6Halogenated cycloalkyl and C1-C4Halogenated alkoxy.
According to an embodiment, R1aIndependently selected from halogen, OH, CN, C1-C2Alkoxyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl and C1-C2Halogenated alkoxy.Specifically, R1aSolely On the spot selected from F, Cl, OH, CN, C1-C2Alkoxyl, cyclopropyl, 1-F-cyclopropyl, 1-Cl- Cyclopropyl and C1-C2Halogenated alkoxy.
R1bFor R1The possible substituent group of cyclic alkyl moiety.
R1bIndividually in accordance with the invention selected from halogen, OH, CN, C1-C4Alkyl, C1-C4Alcoxyl Base, C1-C4Haloalkyl, C3-C8Cycloalkyl, C3-C8Halogenated cycloalkyl and C1-C4Haloalkoxy Base.
According to one embodiment, R1bIndependently selected from halogen, CN, C1-C2Alkyl, C1-C2 Alkoxyl, C1-C2Haloalkyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl and C1-C2Halo Alkoxyl.Specifically, R1bIndependently selected from F, Cl, OH, CN, CH3、OCH3, ring Propyl group, 1-F-cyclopropyl, 1-Cl-cyclopropyl and halogenated methoxy.
According to the present invention, R2For hydrogen, C1-C4Alkyl, C2-C4Alkenyl, C2-C4Alkynyl, wherein R2Aliphatic moiety be not further substituted or with 1,2,3 or at most most probable number MPN Purpose is independently selected from halogen, OH, CN, C1-C4Alkoxyl, C3-C6Cycloalkyl, C3-C6 Halogenated cycloalkyl and C1-C4The identical or different group R of halogenated alkoxy2a。
According to an embodiment, R2For H.
According to another embodiment of the present invention, R2Selected from C1-C4Alkyl, C2-C4Alkenyl, C2-C4 Alkynyl.
According to another embodiment of the present invention, R2Selected from H, C1-C4Alkyl, especially methyl or Ethyl, C2-C4Alkenyl, especially CH2CH=CH2, and C2-C4Alkynyl, especially CH2C ≡CH.Its specific embodiments can find in following table P2.
According to a particular, R2For C1-C4Alkyl, such as CH3、C2H5、CH(CH3)2、 CH2CH2CH3、CH2CH2CH2CH3、CH2CH(CH3)2.Another embodiment relates to as follows Compound, wherein R2For by 1,2 or 3 or at most most probable number MPN purpose as defined herein and The identical or different group R of institute's preferred definition2aSubstituted C1-C4Alkyl.According to its specific embodiment party Case, R2For C1-C4Haloalkyl, more specifically C1-C2Haloalkyl.According to its another specifically real Execute scheme, R2For C1-C4Alkoxy-C1-C4Alkyl, such as CH2OCH3Or CH2CH2OCH3。 According to its still another embodiment, R2For hydroxyl-C1-C4Alkyl, such as CH2CH2OH.It is another Outer specific embodiments can find in following table P2.
According to still another embodiment, R2For C3-C6Cycloalkyl-C1-C4Alkyl.Another embodiment relates to And following compound, wherein R2For identical or not by 1,2 or 3 or at most most probable number MPN purpose With group R2aSubstituted C3-C6Cycloalkyl-C1-C4Alkyl, more specifically C3-C6Cycloalkyl-C1-C2 Alkyl.Another embodiment relates to following compound, wherein R2For C3-C6Halogenated cycloalkyl-C1-C4 Alkyl, more specifically C3-C6Halogenated cycloalkyl-C1-C2Alkyl.Its specific embodiments can under Table P2 finds.
According to another embodiment, R2For C2-C4Alkenyl, such as CH2CH=CH2、 CH2C(CH3)=CH2Or CH2CH=CHCH3.Another embodiment relates to following compound, its Middle R2For by 1,2 or 3 or at most most probable number MPN purpose as defined herein with institute's preferred definition Identical or different group R2aSubstituted C2-C4Alkenyl.According to its specific embodiments, R2For C2-C4Halogenated alkenyl, such as CH2C (Cl)=CH2And CH2C (H)=CHCl.Have according to its another Body embodiment, R2For C3-C6Cycloalkyl-C2-C4Alkenyl or C3-C6Halogenated cycloalkyl-C2-C4 Alkenyl.Its other specific embodiments can find in following table P2.
According to still another embodiment, R2For C2-C4Alkynyl, such as CH2C ≡ CH or CH2C≡CCH3。 Another embodiment relates to following compound, wherein R2For by 1,2 or 3 or at most maximum possible Number as defined herein with the identical or different group R of institute's preferred definition2aSubstituted C2-C4Alkynes Base.According to its specific embodiments, R2For C2-C4Halo alkynyl.According to its another specific embodiment party Case, R2For C3-C6Cycloalkyl-C2-C4Alkynyl or C3-C6Halogenated cycloalkyl-C2-C4Alkynyl.Its tool Body embodiment can find in following table P2.
R2Particularly preferred embodiment according to the present invention in following table P2, wherein P2-1 to P2-79 Each row of row is corresponding to a particular of the present invention, and wherein P2-1 to P2-79 is also with any It is combined as the preferred embodiments of the invention.
Table P2:
R3Individually in accordance with the invention selected from hydrogen, halogen, CN, C1-C4Alkyl, C1-C4Alkoxyl, C2-C4Alkenyl, C2-C4Alkynyl, C3-C6Cycloalkyl, S (O)p(C1-C4Alkyl), wherein R3Respectively From unsubstituted or by 1,2,3 or 4 R3aIt is further substituted with；Wherein R3aIndependently selected from Halogen, CN, OH, C1-C4Alkyl, C1-C4Haloalkyl, C3-C6Cycloalkyl, C3-C6Halo Cycloalkyl, C1-C4Alkoxyl and C1-C4Halogenated alkoxy, and wherein p is 0,1 or 2.
R3Individually in accordance with the invention selected from halogen, CN, C1-C4Alkyl, C1-C4Alkoxyl, C2-C4 Alkenyl, C2-C4Alkynyl, C3-C6Cycloalkyl, S (O)p(C1-C4Alkyl), wherein R3Each the most not by Replace or by 1,2,3 or 4 R3aIt is further substituted with；Wherein R3aIndependently selected from halogen, CN、OH、C1-C4Alkyl, C1-C4Haloalkyl, C3-C8Cycloalkyl, C3-C8Halogenated cycloalkyl, C1-C4Alkoxyl and C1-C4Halogenated alkoxy, and wherein p is 0,1 or 2.
According to another embodiment, R3Selected from hydrogen, F, Cl, Br, CN, C1-C4Alkyl, C1-C4 Haloalkyl, C1-C4Alkoxyl, C1-C4Halogenated alkoxy, S (C1-C4Alkyl), S (O) (C1-C4 Alkyl) and S (O)2(C1-C4Alkyl).
According to another embodiment, R3Selected from F, Cl, Br, CN, C1-C4Alkyl, C1-C4Halogen Substituted alkyl, C1-C4Alkoxyl, C1-C4Halogenated alkoxy, S (C1-C4Alkyl), S (O) (C1-C4Alkane Base) and S (O)2(C1-C4Alkyl).
R3It is hydrogen according to an embodiment.
According to another embodiment, R3Selected from hydrogen, Cl, F, Br, CN, C1-C2Alkyl, especially It is CH3, C1-C2Haloalkyl, especially CF3, C1-C2Alkoxyl, especially OCH3, with And C1-C2Halogenated alkoxy, especially OCF3。
According to still another embodiment, R3Selected from Cl, F, Br, CN, C1-C2Alkyl, especially CH3, C1-C2Haloalkyl, especially CF3, C1-C2Alkoxyl, especially OCH3, and C1-C2Halogenated alkoxy, especially OCF3。
According to another embodiment, R3Selected from hydrogen, Cl, F, Br, C1-C2Alkyl, especially CH3, C1-C2Haloalkyl, especially CF3, C1-C2Alkoxyl, especially OCH3, and C1-C2 Halogenated alkoxy, especially OCF3。
According to still another embodiment, R3Selected from Cl, F, Br, C1-C2Alkyl, especially CH3, C1-C2Haloalkyl, especially CF3, C1-C2Alkoxyl, especially OCH3, and C1-C2 Halogenated alkoxy, especially OCF3。
According to another embodiment, R3Selected from C2-C4Alkenyl, C2-C4Halogenated alkenyl, C2-C4 Alkynyl and C2-C4Halo alkynyl.According to a particular, R3For C2-C4Alkenyl or C2-C4 Halogenated alkenyl, such as CH=CH2.According to another particular, R3For C2-C4Alkynyl or C2-C4Halo alkynyl, such as C ≡ CH.
According to another embodiment, R3Selected from C3-C6Cycloalkyl and C3-C6Halogenated cycloalkyl.
According to another embodiment, R3Selected from S (C1-C2Alkyl), S (O) (C1-C2Alkyl) and S(O)2(C1-C2Alkyl).According to its particular, R3Selected from SCH3、S(O)(CH3) and S(O)2(CH3)。
According to a specific embodiments, R3For halogen, especially Br, F or Cl, more specifically F Or Cl.
According to another specific embodiments, R3For CN.
According to another specific embodiments, R3For C1-C4Alkyl, such as CH3, or C1-C4Alkyl halide Base, such as CF3、CHF2、CH2F、CCl3、CHCl2Or CH2Cl。
According to another specific embodiments, R3For C1-C4Alkoxyl, more specifically C1-C2Alkoxyl, Such as OCH3Or OCH2CH3, or C1-C4Halogenated alkoxy, more specifically C1-C2Halogenated alkoxy, Such as OCF3、OCHF2、OCH2F、OCCl3、OCHCl2Or OCH2Cl, especially OCF3、 OCHF2、OCCl3Or OCHCl2。
R3aSelected from halogen, CN, OH, C1-C4Alkyl, C1-C4Haloalkyl, C3-C8Cycloalkyl, C3-C8Halogenated cycloalkyl, C1-C4Alkoxyl and C1-C4Halogenated alkoxy, be especially selected from halogen, CN, C1-C2Alkyl, C1-C2Haloalkyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl, C1-C2Alkane Epoxide and C1-C2Halogenated alkoxy.Specifically, R3aIndependently selected from F, Cl, CN, OH, CH3, halogenated methyl, cyclopropyl, halogenated cyclopropyl, OCH3And halogenated methoxy.
R3Particularly preferred embodiment according to the present invention in following table P3, wherein P3-1 to P5-16 Each row of row is corresponding to a particular of the present invention, and wherein P3-1 to P3-16 is also with any It is mutually combined as the preferred embodiments of the invention.Therefore, it is present in the compounds of this invention for each In R3, these specific embodiments and preferred situation are any independent of may reside in benzyl ring Other R3Implication be suitable for:
Table P3:
Z is C3-C8Cycloalkyl or C3-C8Cycloalkenyl group, wherein cycloalkyl or cycloalkenyl group unsubstituted (m=0) Or by (R4)mReplace；Wherein m is 0,1,2,3 or 4；And R4The most independently Selected from halogen, CN, NO2、OH、SH、C1-C6Alkyl, C1-C6Alkoxyl, C2-C6Alkene Base, C2-C6Alkynyl, C3-C6Cycloalkyl, C3-C6Cycloalkyloxy, S (O)p(C1-C4Alkyl), C (=O) (C1-C4Alkyl), C (=O) (OH), C (=O) (O-C1-C4Alkyl), C (=O) (NH (C1-C4 Alkyl)) and C (=O) (N (C1-C4Alkyl)2)；Wherein R4The most unsubstituted or by 1,2,3 or 4 R4aIt is further substituted with, wherein R4aIndependently selected from halogen, CN, NO2、OH、C1-C4 Alkyl, C1-C4Haloalkyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl, C1-C4Alkoxyl and C1-C4Halogenated alkoxy；And wherein p is 0,1 or 2.
According to the present invention it is possible to there are 0,1,2,3 or 4 R4, i.e. m is 0,1,2,3 Or 4.M is especially 0,1,2 or 3.According to an embodiment, m is 0,1 or 2.
According to a particular, m is 0.
According to another embodiment, m is 1,2 or 3, especially 1 or 2, more specifically 1.Root According to one specific embodiments, m is 1, and according to another specific embodiments, m is 2.
According to still another embodiment, m is 2,3 or 4.
According to still another embodiment, m is 3.
For each R being present in the compounds of this invention4, following embodiment and preferred situation are independent In any other R that may reside in benzyl ring4Implication be suitable for.Additionally, herein to R4Given Particular and preferred situation for m=1, m=2, m=3 and m=4 each separately from.
R4It is each independently selected from halogen, CN, NO2、OH、SH、C1-C6Alkyl, C1-C6 Alkoxyl, C2-C6Alkenyl, C2-C6Alkynyl, C3-C6Cycloalkyl, C3-C6Cycloalkyloxy, S(O)p(C1-C4Alkyl), C (=O) (C1-C4Alkyl), C (=O) (OH), C (=O) (O-C1-C4Alkyl), C (=O) (NH (C1-C4Alkyl)) and C (=O) (N (C1-C4Alkyl)2)；Wherein R4The most unsubstituted Or by 1,2,3 or 4 R4aIt is further substituted with, wherein R4aIndependently selected from halogen, CN, NO2、OH、C1-C4Alkyl, C1-C4Haloalkyl, C3-C6Cycloalkyl, C3-C6Halo cycloalkanes Base, C1-C4Alkoxyl and C1-C4Halogenated alkoxy；And wherein p is 0,1 or 2.
According to an embodiment, R4Independently selected from halogen, CN, NO2、C1-C4Alkyl, C1-C4 Alkoxyl, C2-C4Alkenyl, C2-C4Alkynyl, C3-C6Cycloalkyl, C3-C6Cycloalkyloxy, S (C1-C2 Alkyl), S (O) (C1-C2Alkyl), S (O)2(C1-C2Alkyl), C (=O) (C1-C2Alkyl), C (=O) (OH) With C (=O) (O-C1-C2Alkyl), wherein R4The most unsubstituted or only by 1,2,3 or 4 The vertical R selected4aIt is further substituted with, wherein R4aAs defined herein with institute's preferred definition.
According to another embodiment, R4Independently selected from halogen, CN, NO2、C1-C4Alkyl, C1-C4 Haloalkyl, C1-C4Alkoxyl, C1-C4Halogenated alkoxy, C2-C4Alkenyl, C2-C4Halo chain Thiazolinyl, C2-C4Alkynyl, C2-C4Halo alkynyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl, S (C1-C2 Alkyl), S (O) (C1-C2Alkyl), S (O)2(C1-C2Alkyl), C (=O) (C1-C2Alkyl), C (=O) (OH) With C (=O) (O-C1-C2Alkyl).
According to another embodiment, R4Independently selected from halogen, CN, NO2、C1-C2Alkyl, C1-C2 Haloalkyl, C1-C2Alkoxyl, C1-C2Halogenated alkoxy, S (C1-C2Alkyl), S (O) (C1-C2 Alkyl), S (O)2(C1-C2Alkyl), C (=O) (OH) and C (=O) (O-C1-C2Alkyl).
According to another embodiment, R4Independently selected from F, Cl, Br, CN, C1-C4Alkyl, C1-C4 Haloalkyl, C1-C4Alkoxyl, C1-C4Halogenated alkoxy, S (C1-C4Alkyl), S (O) (C1-C4 Alkyl) and S (O)2(C1-C4Alkyl).
According to another embodiment, R4Independently selected from F, Cl, Br, CN, methyl, C1Halo Alkyl, methoxyl group and C1Halogenated alkoxy, more specifically selected from F, Cl, CN and methyl.
According to still another embodiment, R4Independently selected from halogen, it is especially selected from Br, F and Cl, More specifically selected from F and Cl.
According to another specific embodiments, R4For CN.
According to another specific embodiments, R4For C1-C4Alkyl, such as CH3.Other suitable alkyl It is ethyl, n-pro-pyl, isopropyl, normal-butyl, isobutyl group and the tert-butyl group.
According to another specific embodiments, R4For C1-C4Haloalkyl, such as CF3、CHF2、CH2F、 CCl3、CHCl2Or CH2Cl。
According to another specific embodiments, R4For C1-C4Alkoxyl, more specifically C1-C2Alkoxyl, Such as OCH3Or OCH2CH3。
According to another specific embodiments, R4For C1-C4Halogenated alkoxy, more specifically C1-C2Halogen For alkoxyl, such as OCF3、OCHF2、OCH2F、OCCl3、OCHCl2Or OCH2Cl, Especially OCF3、OCHF2、OCCl3Or OCHCl2。
According to still another embodiment, R4For C2-C6Alkenyl or C2-C6Halogenated alkenyl, especially C2-C4Alkenyl or C2-C4Halogenated alkenyl, such as CH=CH2、CH2CH=CH2、 CH=CHCH3Or C (CH3)=CH2。
According to still another embodiment, R4For C2-C6Alkynyl or C2-C6Halo alkynyl, especially C2-C4 Alkynyl or C2-C4Halo alkynyl, such as C ≡ CH, CH2CCH or CH2CCCH3。
According to another embodiment, R4For C3-C6Cycloalkyloxy.In specific embodiments, R4For O-ring propyl group.
According to another embodiment, R4For C3-C6Cycloalkyl, preferably cyclopropyl, cyclobutyl, ring penta Base or cyclohexyl, especially cyclopropyl or cyclobutyl.In specific embodiments, R4For cyclopropyl. In another particular embodiment, R4For cyclobutyl.In another particular embodiment, R4For ring penta Base.In another particular embodiment, R4For cyclohexyl.
According to specific embodiments, R4C for halo wholly or in part3-C6Cycloalkyl.In specific reality Execute in scheme, R4Cyclopropyl for halo wholly or in part.In another particular embodiment, R4 For 1-Cl-cyclopropyl.In another particular embodiment, R4For 2-Cl-cyclopropyl.Specific at another In embodiment, R4For 1-F-cyclopropyl.In another particular embodiment, R4For 2-F-cyclopropyl. In another particular embodiment, R4Cyclobutyl for halo wholly or in part.At another particular implementation In scheme, R4For 1-Cl-cyclobutyl.In another particular embodiment, R4For 1-F-cyclobutyl. In another particular embodiment, R4For 3,3-Cl2-cyclobutyl.In another particular embodiment, R4For 3,3-F2-cyclobutyl.According to specific embodiments, R4For by C1-C4The substituted C of alkyl3-C6 Cycloalkyl.In specific embodiments, R4For 1-CH3-cyclopropyl.According to specific embodiments, R4For the C replaced by CN3-C6Cycloalkyl.In specific embodiments, R4For 1-CN-cyclopropyl. According to another specific embodiments, R4For C3-C6Cycloalkyl-C3-C6Cycloalkyl.In particular implementation side In case, R4For cyclopropyl-cyclopropyl.In specific embodiments, R4For 2-cyclopropyl-cyclopropyl. According to another specific embodiments, R4For C3-C6Cycloalkyl-C3-C6Halogenated cycloalkyl.
According to another embodiment, R4For C3-C8Cycloalkyl-C1-C4Alkyl, preferably C3-C6Cycloalkanes Base-C1-C4Alkyl.In specific embodiments, R4For CH (CH3) (cyclopropyl).Specific at another In embodiment, R4For CH2-(cyclopropyl).
According to still another embodiment, R4Selected from C (=O) (C1-C4Alkyl), C (=O) (OH), C (=O) (O-C1-C4Alkyl), C (=O) (NH (C1-C4Alkyl)) and C (=O) (N (C1-C4Alkyl)2), It is especially selected from C (=O) (C1-C2Alkyl), C (=O) (OH), C (=O) (O-C1-C2Alkyl), C (=O) (NH (C1-C2Alkyl)) and C (=O) (N (C1-C2Alkyl)2).According to one specific embodiment party Case, R4For C (=O) (OH) or C (=O) (O-C1-C4Alkyl), especially C (=O) (OCH3)。
According to another embodiment, R4For C (=O) (-C1-C4Alkyl).According to specific embodiments, R4For C (=O) CH3.According to another specific embodiments, R4For C (=O) CH2CH3.According to separately One specific embodiments, R4For C (=O) CH2CH2CH3.According to another specific embodiments, R4 For C (=O) CH (CH3)2.According to another specific embodiments, R4For C (=O) C (CH3)3。
According to another embodiment, R4For C (=O) OH.
According to another embodiment, R4For C (=O) (-O-C1-C4Alkyl).According to specific embodiments, R4For C (=O) OCH3.According to another specific embodiments, R4For C (=O) OCH2CH3.According to Another specific embodiments, R4For C (=O) OCH2CH2CH3.According to another specific embodiments, R4For C (=O) OCH (CH3)2.According to another specific embodiments, R4For C (=O) OC (CH3)3。
According to another embodiment, R4For C (=O)-NH (C1-C4Alkyl).According to specific embodiments, R4For C (=O) NHCH3.According to another specific embodiments, R4For C (=O) NHCH2CH3。 According to another specific embodiments, R4For C (=O) NHCH2CH2CH3.It is embodied as according to another Scheme, R4For C (=O) NHCH (CH3)2.According to another specific embodiments, R42For C (=O) NHC (CH3)3。
According to another embodiment, R4For C (=O)-N (C1-C4Alkyl)2.According to specific embodiments, R4For C (=O) N (CH3)2.According to another specific embodiments, R4For C (=O) N (CH2CH3)2。 According to another specific embodiments, R4For C (=O) N (CH2CH2CH3)2.It is embodied as according to another Scheme, R4For C (=O) N (CH (CH3)2)2.According to another specific embodiments, R4For C (=O) N (C (CH3)3)2。
According to still another embodiment, R4Selected from S (C1-C2Alkyl), S (O) (C1-C2Alkyl) and S(O)2(C1-C2Alkyl), especially SCH3、S(O)(CH3) and S (O)2(CH3).According to concrete real Execute scheme, R4Selected from S (C1-C2Haloalkyl), S (O) (C1-C2Haloalkyl) and S (O)2(C1-C2 Haloalkyl), such as SO2CF3。
R4Particularly preferred embodiment according to the present invention in following table P4, wherein P4-1 to P4-17 Each row of row is corresponding to a particular of the present invention, and wherein P4-1 to P4-17 is also with any It is mutually combined as the preferred embodiments of the invention.Therefore, it is present in the compounds of this invention for each In R4, these specific embodiments and preferred situation are any independent of may reside in benzyl ring Other R4Implication be suitable for:
Table P4:
According to an embodiment, Z is C3-C8Cycloalkyl, wherein said cycloalkyl unsubstituted or Person is by (R4)mReplace, wherein m and R4As defined above with institute's preferred definition.
Z is especially for C3-C6Cycloalkyl, wherein said cycloalkyl is unsubstituted or by (R4)mReplace, Wherein m and R4As defined above with institute's preferred definition.
According to a particular, Z is cyclopropyl, wherein said cyclopropyl unsubstituted or By (R4)mReplace, wherein m and R4As defined above with institute's preferred definition.
According to another particular, Z is cyclobutyl, wherein said cyclobutyl unsubstituted or By (R4)mReplace, wherein m and R4As defined above with institute's preferred definition.
According to another particular, Z is cyclopenta, wherein said cyclopenta unsubstituted or By (R4)mReplace, wherein m and R4As defined above with institute's preferred definition.
According to another particular, Z is cyclohexyl, wherein said cyclohexyl unsubstituted or By (R4)mReplace, wherein m and R4As defined above with institute's preferred definition.
According to another particular, Z is suberyl, wherein said suberyl unsubstituted or By (R4)mReplace, wherein m and R4As defined above with institute's preferred definition.
According to another particular, Z is ring octyl group, wherein said ring octyl group unsubstituted or By (R4)mReplace, wherein m and R4As defined above with institute's preferred definition.
If Z is C3-C8Cycloalkyl, then the particularly preferred embodiment of Z according to the present invention in following table Z1 In, wherein each row of Z1-1 to Z1-28 row is corresponding to a particular of the present invention, its Middle Z1-1 to Z1-28 is also combined as the preferred embodiments of the invention with any.
Table Z1:
According to another embodiment, Z is C3-C8Cycloalkenyl group, wherein said cycloalkenyl group unsubstituted or Person is by (R4)mReplace, wherein m and R4As defined above with institute's preferred definition.Preferably this cycloalkenyl group exists Containing 1 or 2 double bond in ring, especially 1 double bond.According to an embodiment, described double bond Be positioned adjacent to the connection carbon atom of three key in Z and Formulas I, i.e. Z is C3-C6Cyclenes-1-base.
Z is especially C3-C6Cycloalkenyl group, wherein said cycloalkenyl group is unsubstituted or by (R4)mReplace, Wherein m and R4As defined above with institute's preferred definition.Preferably this cycloalkenyl group contains 1 or 2 in ring Individual double bond, especially 1 double bond.According to an embodiment, described double bond be positioned adjacent to Z With the connection carbon atom of three key in Formulas I, i.e. Z is C3-C6Cyclenes-1-base.
According to a particular, Z is cyclopropanyl, more specifically cyclopropylene-1-base, wherein Described cyclopropanyl or cyclopropylene-1-base is unsubstituted or by (R4)mReplace, wherein m and R4As above Defined and institute's preferred definition.
According to another particular, Z is cyclobutane base, more specifically cyclobutane-1-base, wherein Described cyclobutane base or cyclobutane-1-base is unsubstituted or by (R4)mReplace, wherein m and R4As above Defined and institute's preferred definition.
According to another particular, Z is cyclopentenyl, more specifically cyclopentenes-1-base, wherein Described cyclopentenyl or cyclopentenes-1-base is unsubstituted or by (R4)mReplace, wherein m and R4As above Defined and institute's preferred definition.
According to another particular, Z is cyclohexenyl group, more specifically cyclohexene-1-base, wherein Described cyclohexenyl group or cyclohexene-1-base is unsubstituted or by (R4)mReplace, wherein m and R4As above Defined and institute's preferred definition.
According to another particular, Z is cycloheptenyl, more specifically cycloheptene-1-base, wherein Described cycloheptenyl or cycloheptene-1-base is unsubstituted or by (R4)mReplace, wherein m and R4As above Defined and institute's preferred definition.
According to another particular, Z is cyclo-octene base, more specifically cyclo-octene-1-base, wherein Described cyclo-octene base or cyclo-octene-1-base is unsubstituted or by (R4)mReplace, wherein m and R4As above Defined and institute's preferred definition.
If Z is C3-C8Cycloalkenyl group, then the particularly preferred embodiment of Z according to the present invention in following table Z2 In, wherein each row of Z2-1 to Z1-16 row is corresponding to a particular of the present invention, its Middle Z2-1 to Z2-16 is also combined as the preferred embodiments of the invention with any.
Table Z2:
One embodiment relates to following compound I, and wherein A is N (I.A):
In an embodiment of I.A, Z is C3-C6Cycloalkyl (compound I.A1), wherein cycloalkanes Base unsubstituted (m=0) or quilt (R4)mReplace.
Its specific embodiments is following I.A1a (A=N, Z=cyclopropyl), I.A1b (A=N, Z=ring fourth Base), I.A1c (A=N, Z=cyclopenta) and I.A1d (A=N, Z=cyclohexyl):
In the another embodiment of I.A, Z is C3-C6Cycloalkenyl group (compound I.A2), wherein cyclenes Base unsubstituted (m=0) or quilt (R4)mReplace.
Its specific embodiments is following I.A2a (A=N, Z=cyclopropylene-1-base), I.A2b (A=N, Z=cyclobutane-1-base), I.A2c (A=N, Z=cyclopentenes-1-base) and I.A2d (A=N, Z=cyclohexene-1- Base):
Another embodiment relates to following compound I, and wherein A is CH (I.B).
In one embodiment, Z is C3-C6Cycloalkyl (compound I.B1), wherein cycloalkyl is not It is replaced (m=0) or by (R4)mReplace.
The specific embodiments of I.B is following I.B1a (A=N, Z=cyclopropyl), I.B1b (A=N, Z= Cyclobutyl), I.B1c (A=N, Z=cyclopenta) and I.B1d (A=N, Z=cyclohexyl):
In the another embodiment of I.B, Z is C3-C6Cycloalkenyl group (compound I.B2), wherein cyclenes Base unsubstituted (m=0) or quilt (R4)mReplace.
Its specific embodiments is following I.B2a (A=N, Z=cyclopropylene-1-base), I.B2b (A=N, Z= Cyclobutane-1-base), I.B2c (A=N, Z=cyclopentenes-1-base) and I.B2d (A=N, Z=cyclohexene-1-base):
Especially consider its purposes, according to an embodiment, be preferably compiled in table 1 below a-49a, table Formulas I .A1 in 1b-49b, table 1c-35c, table 1d-35d, table 1e-7e and table 1f-7f and I.A2ization Compound.Additionally, the group that substituent group in table is mentioned each this particularly preferred as described substituent group Aspect, and it is mentioned that its combination is unrelated.
Table 1a wherein (R4)mIn m be 0, R3D1-1 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-1.B1 to I.A1a.D1-1.B455).
Table 2a wherein (R4)mIn m be 0, R3D1-2 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-2.B1 to I.A1a.D1-2.B455).
Table 3a wherein (R4)mIn m be 0, R3D1-3 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-3.B1 to I.A1a.D1-3.B455).
Table 4a wherein (R4)mIn m be 0, R3D1-4 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-4.B1 to I.A1a.D1-4.B455).
Table 5a wherein (R4)mIn m be 0, R3D1-5 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-5.B1 to I.A1a.D1-5.B455).
Table 6a wherein (R4)mIn m be 0, R3D1-6 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-6.B1 to I.A1a.D1-6.B455).
Table 7a wherein (R4)mIn m be 0, R3D1-7 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-7.B1 to I.A1a.D1-7.B455).
Table 8a wherein (R4)mFor 1-Cl, R3D1-1 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-1.B1 to I.A1a.D1-1.B455).
Table 9a wherein (R4)mFor 1-Cl, R3D1-2 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-2.B1 to I.A1a.D1-2.B455).
Table 10a wherein (R4)mFor 1-Cl, R3D1-3 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-3.B1 to I.A1a.D1-3.B455).
Table 11a wherein (R4)mFor 1-Cl, R3D1-4 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-4.B1 to I.A1a.D1-4.B455).
Table 12a wherein (R4)mFor 1-Cl, R3D1-5 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-5.B1 to I.A1a.D1-5.B455).
Table 13a wherein (R4)mFor 1-Cl, R3D1-6 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-6.B1 to I.A1a.D1-6.B455).
Table 14a wherein (R4)mFor 1-Cl, R3D1-7 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-7.B1 to I.A1a.D1-7.B455).
Table 15a wherein (R4)mFor 1-F, R3D1-1 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-1.B1 to I.A1a.D1-1.B455).
Table 16a wherein (R4)mFor 1-F, R3D1-2 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-2.B1 to I.A1a.D1-2.B455).
Table 17a wherein (R4)mFor 1-F, R3D1-3 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-3.B1 to I.A1a.D1-3.B455).
Table 18a wherein (R4)mFor 1-F, R3D1-4 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-4.B1 to I.A1a.D1-4.B455).
Table 19a wherein (R4)mFor 1-F, R3D1-5 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-5.B1 to I.A1a.D1-5.B455).
Table 20a wherein (R4)mFor 1-F, R3D1-6 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-6.B1 to I.A1a.D1-6.B455).
Table 21a wherein (R4)mFor 1-F, R3D1-7 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1a compound (compound I.A1a.D1-7.B1 to I.A1a.D1-7.B455).
Table 22a wherein (R4)mFor 1-CH3, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-1.B1 to I.A1a.D1-1.B455).
Table 23a wherein (R4)mFor 1-CH3, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-2.B1 to I.A1a.D1-2.B455).
Table 24a wherein (R4)mFor 1-CH3, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-3.B1 to I.A1a.D1-3.B455).
Table 25a wherein (R4)mFor 1-CH3, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-4.B1 to I.A1a.D1-4.B455).
Table 26a wherein (R4)mFor 1-CH3, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-5.B1 to I.A1a.D1-5.B455).
Table 27a wherein (R4)mFor 1-CH3, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-6.B1 to I.A1a.D1-6.B455).
Table 28a wherein (R4)mFor 1-CH3, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-7.B1 to I.A1a.D1-7.B455).
Table 29a wherein (R4)mFor 1-CN, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-1.B1 to I.A1a.D1-1.B455).
Table 30a wherein (R4)mFor 1-CN, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-2.B1 to I.A1a.D1-2.B455).
Table 31a wherein (R4)mFor 1-CN, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-3.B1 to I.A1a.D1-3.B455).
Table 32a wherein (R4)mFor 1-CN, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-4.B1 to I.A1a.D1-4.B455).
Table 33a wherein (R4)mFor 1-CN, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-5.B1 to I.A1a.D1-5.B455).
Table 34a wherein (R4)mFor 1-CN, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-6.B1 to I.A1a.D1-6.B455).
Table 35a wherein (R4)mFor 1-CN, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-7.B1 to I.A1a.D1-7.B455).
Table 36a wherein (R4)mFor 2,2-Cl2, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-1.B1 to I.A1a.D1-1.B455).
Table 37a wherein (R4)mFor 2,2-Cl2, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-2.B1 to I.A1a.D1-2.B455).
Table 38a wherein (R4)mFor 2,2-Cl2, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-3.B1 to I.A1a.D1-3.B455).
Table 39a wherein (R4)mFor 2,2-Cl2, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-4.B1 to I.A1a.D1-4.B455).
Table 40a wherein (R4)mFor 2,2-Cl2, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-5.B1 to I.A1a.D1-5.B455).
Table 41a wherein (R4)mFor 2,2-Cl2, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-6.B1 to I.A1a.D1-6.B455).
Table 42a wherein (R4)mFor 2,2-Cl2, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1a compound (compound I.A1a.D1-7.B1 to I.A1a.D1-7.B455).
Table 43a wherein (R4)mFor 2,2-(CH3)2, R3D1-1 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1a compound (compound I.A1a.D1-1.B1 to I.A1a.D1-1.B455) of row.
Table 44a wherein (R4)mFor 2,2-(CH3)2, R3D1-2 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1a compound (compound I.A1a.D1-2.B1 to I.A1a.D1-2.B455) of row.
Table 45a wherein (R4)mFor 2,2-(CH3)2, R3D1-3 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1a compound (compound I.A1a.D1-3.B1 to I.A1a.D1-3.B455) of row.
Table 46a wherein (R4)mFor 2,2-(CH3)2, R3D1-4 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1a compound (compound I.A1a.D1-4.B1 to I.A1a.D1-4.B455) of row.
Table 47a wherein (R4)mFor 2,2-(CH3)2, R3D1-5 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1a compound (compound I.A1a.D1-5.B1 to I.A1a.D1-5.B455) of row.
Table 48a wherein (R4)mFor 2,2-(CH3)2, R3D1-6 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1a compound (compound I.A1a.D1-6.B1 to I.A1a.D1-6.B455) of row.
Table 49a wherein (R4)mFor 2,2-(CH3)2, R3D1-7 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1a compound (compound I.A1a.D1-7.B1 to I.A1a.D1-7.B455) of row.
Table 1b wherein (R4)mIn m be 0, R3D1-1 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-1.B1 to I.A1b.D1-1.B455).
Table 2b wherein (R4)mIn m be 0, R3D1-2 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-2.B1 to I.A1b.D1-2.B455).
Table 3b wherein (R4)mIn m be 0, R3D1-3 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-3.B1 to I.A1b.D1-3.B455).
Table 4b wherein (R4)mIn m be 0, R3D1-4 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-4.B1 to I.A1b.D1-4.B455).
Table 5b wherein (R4)mIn m be 0, R3D1-5 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-5.B1 to I.A1b.D1-5.B455).
Table 6b wherein (R4)mIn m be 0, R3D1-6 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-6.B1 to I.A1b.D1-6.B455).
Table 7b wherein (R4)mIn m be 0, R3D1-7 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-7.B1 to I.A1b.D1-7.B455).
Table 8b wherein (R4)mFor 1-Cl, R3D1-1 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-1.B1 to I.A1b.D1-1.B455).
Table 9b wherein (R4)mFor 1-Cl, R3D1-2 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-2.B1 to I.A1b.D1-2.B455).
Table 10b wherein (R4)mFor 1-Cl, R3D1-3 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-3.B1 to I.A1b.D1-3.B455).
Table 11b wherein (R4)mFor 1-Cl, R3D1-4 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-4.B1 to I.A1b.D1-4.B455).
Table 12b wherein (R4)mFor 1-Cl, R3D1-5 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-5.B1 to I.A1b.D1-5.B455).
Table 13b wherein (R4)mFor 1-Cl, R3D1-6 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-6.B1 to I.A1b.D1-6.B455).
Table 14b wherein (R4)mFor 1-Cl, R3D1-7 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-7.B1 to I.A1b.D1-7.B455).
Table 15b wherein (R4)mFor 1-F, R3D1-1 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-1.B1 to I.A1b.D1-1.B455).
Table 16b wherein (R4)mFor 1-F, R3D1-2 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-2.B1 to I.A1b.D1-2.B455).
Table 17b wherein (R4)mFor 1-F, R3D1-3 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-3.B1 to I.A1b.D1-3.B455).
Table 18b wherein (R4)mFor 1-F, R3D1-4 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-4.B1 to I.A1b.D1-4.B455).
Table 19b wherein (R4)mFor 1-F, R3D1-5 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-5.B1 to I.A1b.D1-5.B455).
Table 20b wherein (R4)mFor 1-F, R3D1-6 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-6.B1 to I.A1b.D1-6.B455).
Table 21b wherein (R4)mFor 1-F, R3D1-7 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1b compound (compound I.A1b.D1-7.B1 to I.A1b.D1-7.B455).
Table 22b wherein (R4)mFor 1-CH3, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-1.B1 to I.A1b.D1-1.B455).
Table 23b wherein (R4)mFor 1-CH3, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-2.B1 to I.A1b.D1-2.B455).
Table 24b wherein (R4)mFor 1-CH3, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-3.B1 to I.A1b.D1-3.B455).
Table 25b wherein (R4)mFor 1-CH3, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-4.B1 to I.A1b.D1-4.B455).
Table 26b wherein (R4)mFor 1-CH3, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-5.B1 to I.A1b.D1-5.B455).
Table 27b wherein (R4)mFor 1-CH3, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-6.B1 to I.A1b.D1-6.B455).
Table 28b wherein (R4)mFor 1-CH3, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-7.B1 to I.A1b.D1-7.B455).
Table 29b wherein (R4)mFor 1-CN, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-1.B1 to I.A1b.D1-1.B455).
Table 30b wherein (R4)mFor 1-CN, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-2.B1 to I.A1b.D1-2.B455).
Table 31b wherein (R4)mFor 1-CN, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-3.B1 to I.A1b.D1-3.B455).
Table 32b wherein (R4)mFor 1-CN, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-4.B1 to I.A1b.D1-4.B455).
Table 33b wherein (R4)mFor 1-CN, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-5.B1 to I.A1b.D1-5.B455).
Table 34b wherein (R4)mFor 1-CN, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-6.B1 to I.A1b.D1-6.B455).
Table 35b wherein (R4)mFor 1-CN, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-7.B1 to I.A1b.D1-7.B455).
Table 36b wherein (R4)mFor 3,3-Cl2, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-1.B1 to I.A1b.D1-1.B455).
Table 37b wherein (R4)mFor 3,3-Cl2, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-2.B1 to I.A1b.D1-2.B455).
Table 38b wherein (R4)mFor 3,3-Cl2, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-3.B1 to I.A1b.D1-3.B455).
Table 39b wherein (R4)mFor 3,3-Cl2, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-4.B1 to I.A1b.D1-4.B455).
Table 40b wherein (R4)mFor 3,3-Cl2, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-5.B1 to I.A1b.D1-5.B455).
Table 41b wherein (R4)mFor 3,3-Cl2, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-6.B1 to I.A1b.D1-6.B455).
Table 42b wherein (R4)mFor 3,3-Cl2, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1b compound (compound I.A1b.D1-7.B1 to I.A1b.D1-7.B455).
Table 43b wherein (R4)mFor 3,3-(CH3)2, R3D1-1 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1b compound (compound I.A1b.D1-1.B1 to I.A1b.D1-1.B455) of row.
Table 44b wherein (R4)mFor 3,3-(CH3)2, R3D1-2 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1b compound (compound I.A1b.D1-2.B1 to I.A1b.D1-2.B455) of row.
Table 45b wherein (R4)mFor 3,3-(CH3)2, R3D1-3 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1b compound (compound I.A1b.D1-3.B1 to I.A1b.D1-3.B455) of row.
Table 46b wherein (R4)mFor 3,3-(CH3)2, R3D1-4 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1b compound (compound I.A1b.D1-4.B1 to I.A1b.D1-4.B455) of row.
Table 47b wherein (R4)mFor 3,3-(CH3)2, R3D1-5 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1b compound (compound I.A1b.D1-5.B1 to I.A1b.D1-5.B455) of row.
Table 48b wherein (R4)mFor 3,3-(CH3)2, R3D1-6 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1b compound (compound I.A1b.D1-6.B1 to I.A1b.D1-6.B455) of row.
Table 49b wherein (R4)mFor 3,3-(CH3)2, R3D1-7 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .A1b compound (compound I.A1b.D1-7.B1 to I.A1b.D1-7.B455) of row.
Table 1c wherein (R4)mIn m be 0, R3D1-1 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-1.B1 to I.A1c.D1-1.B455).
Table 2c wherein (R4)mIn m be 0, R3D1-2 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-2.B1 to I.A1c.D1-2.B455).
Table 3c wherein (R4)mIn m be 0, R3D1-3 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-3.B1 to I.A1c.D1-3.B455).
Table 4c wherein (R4)mIn m be 0, R3D1-4 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-4.B1 to I.A1c.D1-4.B455).
Table 5c wherein (R4)mIn m be 0, R3D1-5 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-5.B1 to I.A1c.D1-5.B455).
Table 6c wherein (R4)mIn m be 0, R3D1-6 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-6.B1 to I.A1c.D1-6.B455).
Table 7c wherein (R4)mIn m be 0, R3D1-7 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-7.B1 to I.A1c.D1-7.B455).
Table 8c wherein (R4)mFor 1-Cl, R3D1-1 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-1.B1 to I.A1c.D1-1.B455).
Table 9c wherein (R4)mFor 1-Cl, R3D1-2 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-2.B1 to I.A1c.D1-2.B455).
Table 10c wherein (R4)mFor 1-Cl, R3D1-3 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-3.B1 to I.A1c.D1-3.B455).
Table 11c wherein (R4)mFor 1-Cl, R3D1-4 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-4.B1 to I.A1c.D1-4.B455).
Table 12c wherein (R4)mFor 1-Cl, R3D1-5 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-5.B1 to I.A1c.D1-5.B455).
Table 13c wherein (R4)mFor 1-Cl, R3D1-6 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-6.B1 to I.A1c.D1-6.B455).
Table 14c wherein (R4)mFor 1-Cl, R3D1-7 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-7.B1 to I.A1c.D1-7.B455).
Table 15c wherein (R4)mFor 1-F, R3D1-1 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-1.B1 to I.A1c.D1-1.B455).
Table 16c wherein (R4)mFor 1-F, R3D1-2 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-2.B1 to I.A1c.D1-2.B455).
Table 17c wherein (R4)mFor 1-F, R3D1-3 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-3.B1 to I.A1c.D1-3.B455).
Table 18c wherein (R4)mFor 1-F, R3D1-4 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-4.B1 to I.A1c.D1-4.B455).
Table 19c wherein (R4)mFor 1-F, R3D1-5 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-5.B1 to I.A1c.D1-5.B455).
Table 20c wherein (R4)mFor 1-F, R3D1-6 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-6.B1 to I.A1c.D1-6.B455).
Table 21c wherein (R4)mFor 1-F, R3D1-7 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1c compound (compound I.A1c.D1-7.B1 to I.A1c.D1-7.B455).
Table 22c wherein (R4)mFor 1-CH3, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-1.B1 to I.A1c.D1-1.B455).
Table 23c wherein (R4)mFor 1-CH3, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-2.B1 to I.A1c.D1-2.B455).
Table 24c wherein (R4)mFor 1-CH3, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-3.B1 to I.A1c.D1-3.B455).
Table 25c wherein (R4)mFor 1-CH3, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-4.B1 to I.A1c.D1-4.B455).
Table 26c wherein (R4)mFor 1-CH3, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-5.B1 to I.A1c.D1-5.B455).
Table 27c wherein (R4)mFor 1-CH3, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-6.B1 to I.A1c.D1-6.B455).
Table 28c wherein (R4)mFor 1-CH3, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-7.B1 to I.A1c.D1-7.B455).
Table 29c wherein (R4)mFor 1-CN, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-1.B1 to I.A1c.D1-1.B455).
Table 30c wherein (R4)mFor 1-CN, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-2.B1 to I.A1c.D1-2.B455).
Table 31c wherein (R4)mFor 1-CN, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-3.B1 to I.A1c.D1-3.B455).
Table 32c wherein (R4)mFor 1-CN, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-4.B1 to I.A1c.D1-4.B455).
Table 33c wherein (R4)mFor 1-CN, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-5.B1 to I.A1c.D1-5.B455).
Table 34c wherein (R4)mFor 1-CN, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-6.B1 to I.A1c.D1-6.B455).
Table 35c wherein (R4)mFor 1-CN, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1c compound (compound I.A1c.D1-7.B1 to I.A1c.D1-7.B455).
Table 1d wherein (R4)mIn m be 0, R3D1-1 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-1.B1 to I.A1d.D1-1.B455).
Table 2d wherein (R4)mIn m be 0, R3D1-2 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-2.B1 to I.A1d.D1-2.B455).
Table 3d wherein (R4)mIn m be 0, R3D1-3 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-3.B1 to I.A1d.D1-3.B455).
Table 4d wherein (R4)mIn m be 0, R3D1-4 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-4.B1 to I.A1d.D1-4.B455).
Table 5d wherein (R4)mIn m be 0, R3D1-5 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-5.B1 to I.A1d.D1-5.B455).
Table 6d wherein (R4)mIn m be 0, R3D1-6 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-6.B1 to I.A1d.D1-6.B455).
Table 7d wherein (R4)mIn m be 0, R3D1-7 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-7.B1 to I.A1d.D1-7.B455).
Table 8d wherein (R4)mFor 1-Cl, R3D1-1 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-1.B1 to I.A1d.D1-1.B455).
Table 9d wherein (R4)mFor 1-Cl, R3D1-2 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-2.B1 to I.A1d.D1-2.B455).
Table 10d wherein (R4)mFor 1-Cl, R3D1-3 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-3.B1 to I.A1d.D1-3.B455).
Table 11d wherein (R4)mFor 1-Cl, R3D1-4 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-4.B1 to I.A1d.D1-4.B455).
Table 12d wherein (R4)mFor 1-Cl, R3D1-5 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-5.B1 to I.A1d.D1-5.B455).
Table 13d wherein (R4)mFor 1-Cl, R3D1-6 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-6.B1 to I.A1d.D1-6.B455).
Table 14d wherein (R4)mFor 1-Cl, R3D1-7 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-7.B1 to I.A1d.D1-7.B455).
Table 15d wherein (R4)mFor 1-F, R3D1-1 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-1.B1 to I.A1d.D1-1.B455).
Table 16d wherein (R4)mFor 1-F, R3D1-2 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-2.B1 to I.A1d.D1-2.B455).
Table 17d wherein (R4)mFor 1-F, R3D1-3 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-3.B1 to I.A1d.D1-3.B455).
Table 18d wherein (R4)mFor 1-F, R3D1-4 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-4.B1 to I.A1d.D1-4.B455).
Table 19d wherein (R4)mFor 1-F, R3D1-5 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-5.B1 to I.A1d.D1-5.B455).
Table 20d wherein (R4)mFor 1-F, R3D1-6 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-6.B1 to I.A1d.D1-6.B455).
Table 21d wherein (R4)mFor 1-F, R3D1-7 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.A1d compound (compound I.A1d.D1-7.B1 to I.A1d.D1-7.B455).
Table 22d wherein (R4)mFor 1-CH3, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-1.B1 to I.A1d.D1-1.B455).
Table 23d wherein (R4)mFor 1-CH3, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-2.B1 to I.A1d.D1-2.B455).
Table 24d wherein (R4)mFor 1-CH3, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-3.B1 to I.A1d.D1-3.B455).
Table 25d wherein (R4)mFor 1-CH3, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-4.B1 to I.A1d.D1-4.B455).
Table 26d wherein (R4)mFor 1-CH3, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-5.B1 to I.A1d.D1-5.B455).
Table 27d wherein (R4)mFor 1-CH3, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-6.B1 to I.A1d.D1-6.B455).
Table 28d wherein (R4)mFor 1-CH3, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-7.B1 to I.A1d.D1-7.B455).
Table 29d wherein (R4)mFor 1-CN, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-1.B1 to I.A1d.D1-1.B455).
Table 30d wherein (R4)mFor 1-CN, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-2.B1 to I.A1d.D1-2.B455).
Table 31d wherein (R4)mFor 1-CN, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-3.B1 to I.A1d.D1-3.B455).
Table 32d wherein (R4)mFor 1-CN, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-4.B1 to I.A1d.D1-4.B455).
Table 33d wherein (R4)mFor 1-CN, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-5.B1 to I.A1d.D1-5.B455).
Table 34d wherein (R4)mFor 1-CN, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-6.B1 to I.A1d.D1-6.B455).
Table 35d wherein (R4)mFor 1-CN, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .A1d compound (compound I.A1d.D1-7.B1 to I.A1d.D1-7.B455).
Table 1e wherein (R4)mIn m be 0, R3D1-1 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2c compound (compound I.A2c.D1-1.B1 to I.A2c.D1-1.B455).
Table 2e wherein (R4)mIn m be 0, R3D1-2 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2c compound (compound I.A2c.D1-2.B1 to I.A2c.D1-2.B455).
Table 3e wherein (R4)mIn m be 0, R3D1-3 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2c compound (compound I.A2c.D1-3.B1 to I.A2c.D1-3.B455).
Table 4e wherein (R4)mIn m be 0, R3D1-4 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2c compound (compound I.A2c.D1-4.B1 to I.A2c.D1-4.B455).
Table 5e wherein (R4)mIn m be 0, R3D1-5 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2c compound (compound I.A2c.D1-5.B1 to I.A2c.D1-5.B455).
Table 6e wherein (R4)mIn m be 0, R3D1-6 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2c compound (compound I.A2c.D1-6.B1 to I.A2c.D1-6.B455).
Table 7e wherein (R4)mIn m be 0, R3D1-7 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2c compound (compound I.A2c.D1-7.B1 to I.A2c.D1-7.B455).
Table 1f wherein (R4)mIn m be 0, R3D1-1 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2d compound (compound I.A2d.D1-1.B1 to I.A2d.D1-1.B455).
Table 2f wherein (R4)mIn m be 0, R3D1-2 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2d compound (compound I.A2d.D1-2.B1 to I.A2d.D1-2.B455).
Table 3f wherein (R4)mIn m be 0, R3D1-3 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2d compound (compound I.A2d.D1-3.B1 to I.A2d.D1-3.B455).
Table 4f wherein (R4)mIn m be 0, R3D1-4 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2d compound (compound I.A2d.D1-4.B1 to I.A2d.D1-4.B455).
Table f wherein (R4)mIn m be 0, R3D1-5 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2d compound (compound I.A2d.D1-5.B1 to I.A2d.D1-5.B455).
Table 6f wherein (R4)mIn m be 0, R3D1-6 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2d compound (compound I.A2d.D1-6.B1 to I.A2d.D1-6.B455).
Table 7f wherein (R4)mIn m be 0, R3D1-7 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .A2d compound (compound I.A2d.D1-7.B1 to I.A2d.D1-7.B455).
Another embodiment of the invention relates to the Formulas I .B1 compound being compiled in table 1 below g-49g. Additionally, the group mentioning substituent group in table is each originally as the particularly preferred aspect of described substituent group, With it is mentioned that its combination is unrelated.
Table 1g wherein (R4)mIn m be 0, R3D1-1 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-1.B1 to I.B1a.D1-1.B455).
Table 2g wherein (R4)mIn m be 0, R3D1-2 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-2.B1 to I.B1a.D1-2.B455).
Table 3g wherein (R4)mIn m be 0, R3D1-3 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-3.B1 to I.B1a.D1-3.B455).
Table 4g wherein (R4)mIn m be 0, R3D1-4 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-4.B1 to I.B1a.D1-4.B455).
Table 5g wherein (R4)mIn m be 0, R3D1-5 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-5.B1 to I.B1a.D1-5.B455).
Table 6g wherein (R4)mIn m be 0, R3D1-6 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-6.B1 to I.B1a.D1-6.B455).
Table 7g wherein (R4)mIn m be 0, R3D1-7 row and R corresponding to table D11And R2's The implication of combination corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-7.B1 to I.B1a.D1-7.B455).
Table 8g wherein (R4)mFor 1-Cl, R3D1-1 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-1.B1 to I.B1a.D1-1.B455).
Table 9g wherein (R4)mFor 1-Cl, R3D1-2 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-2.B1 to I.B1a.D1-2.B455).
Table 10g wherein (R4)mFor 1-Cl, R3D1-3 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-3.B1 to I.B1a.D1-3.B455).
Table 11g wherein (R4)mFor 1-Cl, R3D1-4 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-4.B1 to I.B1a.D1-4.B455).
Table 12g wherein (R4)mFor 1-Cl, R3D1-5 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-5.B1 to I.B1a.D1-5.B455).
Table 13g wherein (R4)mFor 1-Cl, R3D1-6 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-6.B1 to I.B1a.D1-6.B455).
Table 14g wherein (R4)mFor 1-Cl, R3D1-7 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-7.B1 to I.B1a.D1-7.B455).
Table 15g wherein (R4)mFor 1-F, R3D1-1 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-1.B1 to I.B1a.D1-1.B455).
Table 16g wherein (R4)mFor 1-F, R3D1-2 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-2.B1 to I.B1a.D1-2.B455).
Table 17g wherein (R4)mFor 1-F, R3D1-3 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-3.B1 to I.B1a.D1-3.B455).
Table 18g wherein (R4)mFor 1-F, R3D1-4 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-4.B1 to I.B1a.D1-4.B455).
Table 19g wherein (R4)mFor 1-F, R3D1-5 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-5.B1 to I.B1a.D1-5.B455).
Table 20g wherein (R4)mFor 1-F, R3D1-6 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-6.B1 to I.B1a.D1-6.B455).
Table 21g wherein (R4)mFor 1-F, R3D1-7 row and R corresponding to table D11And R2Combination Implication for each individually oriented compound in each case corresponding to the formula of a line of table B I.B1a compound (compound I.B1a.D1-7.B1 to I.B1a.D1-7.B455).
Table 22g wherein (R4)mFor 1-CH3, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-1.B1 to I.B1a.D1-1.B455).
Table 23g wherein (R4)mFor 1-CH3, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-2.B1 to I.B1a.D1-2.B455).
Table 24g wherein (R4)mFor 1-CH3, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-3.B1 to I.B1a.D1-3.B455).
Table 25g wherein (R4)mFor 1-CH3, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-4.B1 to I.B1a.D1-4.B455).
Table 26g wherein (R4)mFor 1-CH3, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-5.B1 to I.B1a.D1-5.B455).
Table 27g wherein (R4)mFor 1-CH3, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-6.B1 to I.B1a.D1-6.B455).
Table 28g wherein (R4)mFor 1-CH3, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-7.B1 to I.B1a.D1-7.B455).
Table 29g wherein (R4)mFor 1-CN, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-1.B1 to I.B1a.D1-1.B455).
Table 30g wherein (R4)mFor 1-CN, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-2.B1 to I.B1a.D1-2.B455).
Table 31g wherein (R4)mFor 1-CN, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-3.B1 to I.B1a.D1-3.B455).
Table 32g wherein (R4)mFor 1-CN, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-4.B1 to I.B1a.D1-4.B455).
Table 33g wherein (R4)mFor 1-CN, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-5.B1 to I.B1a.D1-5.B455).
Table 34g wherein (R4)mFor 1-CN, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-6.B1 to I.B1a.D1-6.B455).
Table 35g wherein (R4)mFor 1-CN, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-7.B1 to I.B1a.D1-7.B455).
Table 36g wherein (R4)mFor 2,2-Cl2, R3D1-1 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-1.B1 to I.B1a.D1-1.B455).
Table 37g wherein (R4)mFor 2,2-Cl2, R3D1-2 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-2.B1 to I.B1a.D1-2.B455).
Table 38g wherein (R4)mFor 2,2-Cl2, R3D1-3 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-3.B1 to I.B1a.D1-3.B455).
Table 39g wherein (R4)mFor 2,2-Cl2, R3D1-4 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-4.B1 to I.B1a.D1-4.B455).
Table 40g wherein (R4)mFor 2,2-Cl2, R3D1-5 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-5.B1 to I.B1a.D1-5.B455).
Table 41g wherein (R4)mFor 2,2-Cl2, R3D1-6 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-6.B1 to I.B1a.D1-6.B455).
Table 42g wherein (R4)mFor 2,2-Cl2, R3D1-7 row and R corresponding to table D11And R2Group The implication closed corresponds to a line of table B for each individually oriented compound in each case Formulas I .B1a compound (compound I.B1a.D1-7.B1 to I.B1a.D1-7.B455).
Table 43g wherein (R4)mFor 2,2-(CH3)2, R3D1-1 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .B1a compound (compound I.B1a.D1-1.B1 to I.B1a.D1-1.B455) of row.
Table 44g wherein (R4)mFor 2,2-(CH3)2, R3D1-2 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .B1a compound (compound I.B1a.D1-2.B1 to I.B1a.D1-2.B455) of row.
Table 45g wherein (R4)mFor 2,2-(CH3)2, R3D1-3 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .B1a compound (compound I.B1a.D1-3.B1 to I.B1a.D1-3.B455) of row.
Table 46g wherein (R4)mFor 2,2-(CH3)2, R3D1-4 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .B1a compound (compound I.B1a.D1-4.B1 to I.B1a.D1-4.B455) of row.
Table 47g wherein (R4)mFor 2,2-(CH3)2, R3D1-5 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .B1a compound (compound I.B1a.D1-5.B1 to I.B1a.D1-5.B455) of row.
Table 48g wherein (R4)mFor 2,2-(CH3)2, R3D1-6 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .B1a compound (compound I.B1a.D1-6.B1 to I.B1a.D1-6.B455) of row.
Table 49g wherein (R4)mFor 2,2-(CH3)2, R3D1-7 row and R corresponding to table D11And R2 The implication of combination for each individually oriented compound in each case corresponding to the one of table B The Formulas I .B1a compound (compound I.B1a.D1-7.B1 to I.B1a.D1-7.B455) of row.
Table D1:
OK R3
D1-1 H
D1-2 Cl
D1-3 F
D1-4 Br
D1-5 CF3
D1-6 CH3
D1-7 OCH3
Table B:
The compounds of this invention I and compositions are suitable as antifungal respectively.
On the other hand therefore, according to, the present invention relates to compound of formula I, its N-oxide and can be agricultural Salt or present composition purposes in preventing and treating plant pathogenic fungi.
Therefore, present invention additionally comprises a kind of method preventing and treating harmful fungoid, including with effective dose at least A kind of compound of formula I or the present composition process the material of fungus fungus to be prevented invasion and attack, plant, Soil or seed.
The compounds of this invention I and compositions are suitable as antifungal respectively.They are characterised by The plant pathogenic fungi of wide scope [is included especially coming from Plasmodiophoromycetes (Plasmodiophoromycetes), Peronosporomycetes (synonym Oomycete (Oomycetes)), Chytridiomycetes (Chytridiomycetes), Zygomycetes (Zygomycetes), ascus Gammaproteobacteria (Ascomycetes), Basidiomycetes (Basidiomycetes) and deuteromycetes (Deuteromycetes) soil-borne fungus of (synonym Fungi imperfecti (Fungi imperfecti))] have Significantly effect.Inhale in some of which effectively and can use as blade face antifungal, seed dressing Antifungal and soil fungicide are in crop protection.Especially occur additionally, they are suitable for preventing and treating At timber or the harmful fungoid of plant root.
The compounds of this invention I and compositions at various cultivated plants such as Cereal, such as Semen Tritici aestivi, Rye (Secale cereale L.), Fructus Hordei Vulgaris, Triticale hexaploide Lart., Herba bromi japonici or rice；Radix Betae, such as sugar beet or fodder beet；Fruit, Such as a kind of fruit, such as apple, pear, etc., drupe or berry, such as Fructus Mali pumilae, pears, Lee, Fructus Persicae, Semen Armeniacae Amarum, Fructus Pruni pseudocerasi, Fructus Fragariae Ananssae, stirrup Son, blackberry or goose berry；Leguminous plant, such as Seem Lablab Album, Semen Pisi sativi, Herba Medicaginis or Semen sojae atricolor；Oilseed plant, Such as Brassica campestris L, Caulis et Folium Brassicae junceae, Fructus Canarii albi, Helianthi, Cortex cocois radicis, cacao bean, castor oil plant, Elaeis guineensis Jacq., flower Life or Semen sojae atricolor；Cucurbitaceous plant, such as Fructus Cucurbitae moschatae, Fructus Cucumidis sativi or Fructus Melo；Fibre plant, such as Cotton Gossypii, Caulis et Folium Lini, Fructus Cannabis or Corchorus olitorius L.；Cedra fruits, such as Fructus Citri junoris, Fructus Citri Limoniae, grapefruit or Fructus Citri tangerinae；Vegetable, Such as Herba Spinaciae, Caulis et Folium Lactucae sativae, Germinatus Phragmitis, Brassica oleracea L.var.capitata L., Radix Dauci Sativae, Bulbus Allii Cepae, Fructus Lycopersici esculenti, Rhizoma Solani tuber osi, calabash or Green pepper；Laurel class plant, such as American Avocado Tree, Cortex Cinnamomi or Camphora；Energy and material plant, such as beautiful Rice, Semen sojae atricolor, Brassica campestris L, Caulis Sacchari sinensis or Elaeis guineensis Jacq.；Semen Maydis；Nicotiana tabacum L.；Nut；Coffee；Tea；Fructus Musae；Portugal Grape rattan (table grapes and wine Wine grape)；Flos lupuli (Flos Humuli Lupuli)；Lawn；Folium Stevlae Rebaudianae (also referred to as Flos Chrysanthemi (Stevia))； Natural rubber plant or view and admire and forest plants, such as flowers, shrub, broad leaf tree or evergreen tree, example Plant in a large number as coniferous tree, and the crop material of plant propagation material such as seed and these plants prevent and treat Thing pathogenic epiphyte particular importance.
Preferred compound I and combinations thereof thing is respectively used in field crop, such as Rhizoma Solani tuber osi, sugar beet, Nicotiana tabacum L., Semen Tritici aestivi, rye (Secale cereale L.), Fructus Hordei Vulgaris, Herba bromi japonici, rice, Semen Maydis, Cotton Gossypii, Semen sojae atricolor, Brassica campestris L, pulse family are planted Thing, Helianthi, coffee or Caulis Sacchari sinensis；Fruit；Vine；Ornamental plant；Or vegetable such as Fructus Cucumidis sativi, west A large amount of fungus is prevented and treated on red Fructus Kaki, Kidney bean or Fructus Cucurbitae moschatae.
Term " plant propagation material " is understood to mean that all reproductive part such as seed of plant, with And may be used for the such as cutting of asexual vegetable material and the tuber (such as Rhizoma Solani tuber osi) of breeding plant.This includes planting Son, root, fruit, tuber, bulb, subterraneous stem, branch, bud and other plant part, be included in and sprout By rice shoot and the seedling of soil transferring after sending out afterwards or emerging.These seedling can also pass through before transplanting Protect via dipping or the process wholly or in part of pouring.
The most respectively the process of plant propagation material is used at Cereal such as by compound I and combinations thereof thing Semen Tritici aestivi, rye (Secale cereale L.), Fructus Hordei Vulgaris and Herba bromi japonici；A large amount of fungus is prevented and treated on rice, Semen Maydis, Cotton Gossypii and Semen sojae atricolor.
Term " cultivated plant " is understood to include and has passed through breeding, mutation or genetic engineering modification Plant, include but not limited to that the agricultural biotechnologies product of list marketing or exploitation (seeshttp://cera-gmc.org/, see GM crop data storehouse therein).Genetically modified plant is its base Because material not easily passs through hybridization, sudden change or the restructuring obtained of naturally recombinating under field conditions (factors) by using The plant that DNA technique is modified.Generally by the heredity of one or more gene integrations to genetically modified plant To improve some performance of plant in material.This kind of genetic modification also includes but not limited to protein, widow The targeting post translational modification of peptide or polypeptide, such as by glycosylation or polymer addition such as isoprenylation, Acetylation or farnesylation structure division or PEG structure division.
By the plant of breeding, mutation or genetic engineering modification such as because of conventional breeding or gene engineering method And tolerate using of special category herbicide, these herbicides such as auxin herbicide such as Mediben Or 2,4-D (dicamba)；Bleacher herbicides such as medical midbodies of para (ortho)-hydroxybenzoic acetone acid dioxygenase enzyme (HPPD) suppresses Agent or phytoene desaturase (PDS) inhibitor；Acetolactate synthestase (ALS) inhibitor, Such as sulfonylurea or imidazolone type；Enol pyruvylshikimate 3-phosphate synthase (EPSPS) presses down Preparation, such as glyphosate (glyphosate)；Glutamine synthetase (GS) inhibitor, such as glufosinate-ammonium (glufosinate)；Protoporphyrinogen-IX oxidase inhibitor；Lipid biosynthesis inhibitors such as acetyl group CoA carboxylase (ACCase) inhibitor；Or oxynil (i.e. Brominal (bromoxynil) or ioxynil (ioxynil)) herbicide；Additionally, plant tolerates plurality of classes weeding by repeatedly genetic modification Agent, as tolerated both glyphosate and glufosinate-ammonium or tolerance glyphosate and selected from ALS inhibitor, HPPD Both another category herbicides of inhibitor, auximone inhibitor or ACCase inhibitor.These Herbicide tolerant technology is such as described in Pest Managem.Sci.61, and 2005,246；61,2005, 258；61,2005,277；61,2005,269；61,2005,286；64,2008,326； 64,2008,332；Weed Sci.57,2009,108；Austral.J.Agricult.Res.58, 2007,708；Science 316,2007,1185；And in document cited therein.Several cultivations Plant has passed through conventional breeding methods (mutation) herbicide-tolerant, such as imidazolinone resistance such as miaow grass Pyridine acid (imazamox)Summer sowing rape (Canola, Germany BASF SE) or tolerance sulphur Ureide derivative, such as tribenuron-methyl (tribenuron)Helianthi (DuPont, USA). Use gene engineering method to give cultivated plant such as Semen sojae atricolor, Cotton Gossypii, Semen Maydis, Radix Betae and Brassica campestris L pair The toleration of herbicide such as glyphosate and glufosinate-ammonium, some of which can be with trade name(tolerance glyphosate, Monsanto, U.S.A.),(tolerance imidazoles Quinoline ketone, Germany BASF SE) and(tolerance glufosinate-ammonium, Germany Bayer CropScience) Commercial.
Additionally, also include by using recombinant DNA technology can synthesize one or more parasite killing eggs In vain, especially by bacillus (Bacillus) antibacterial, particularly bacillus thuringiensis (Bacillus Thuringiensis) plant of those known to, described insecticidal proteins such as delta-endotoxin, such as CryIA (b), CryIA (c), CryIF, CryIF (a2), CryIIA (b), CryIIIA, CryIIIB (b1) Or Cry9c；Asexual insecticidal proteins (VIP), such as VIP1, VIP2, VIP3 or VIP3A；Nematicide The insecticidal proteins of colonizing bacteria, such as Photobacterium (Photorhabdus) or Xenorhabdus (Xenorhabdus)；Animal produce toxin such as Scorpio toxin, spider venom, wasp toxin or other Insect-specific neurotoxin；Mycetogenetic toxin, such as streptomyces (Streptomycetes) poison Element；Phytohemagglutinin, such as Semen Pisi sativi or barley lectin element；Agglutinin；Protease inhibitor, such as Trypsin inhibitor, serpin, patatin, cystatin Or antipain；Ribosome inactivating protein (RIP), such as ricin, Semen Maydis-RIP, Agglutinin, Seeds of Luffa cylindrica albumen, saporin or different strain diarrhoea toxalbumin (bryodin)；Steroid Metabolic enzyme, such as 3-hydroxy steroid oxidase, ecdysteroids-IDP glycosyl transferase, cholesterol oxygen Change enzyme, ecdyson inhibitor or HMG-CoA reductase；Ion channel blocking agent, such as sodium are logical Road or calcium channel blocker；JH esterase；Diuretic hormone receptor (helicokinin receptor)；Close Become enzyme, bibenzyl synthases, chitinase or glucanase.In the context of the present invention, these parasite killing Albumen or toxin be the most specifically interpreted as front toxin, hybrid protein, truncate or egg that other aspects are modified In vain.Hybrid protein is characterised by the novel compositions (for example, see WO 02/015701) in albumen territory.Should Other examples of the genetically modified plant that toxoid maybe can synthesize these toxin are disclosed in EP-A 374 753、WO 93/007278、WO 95/34656、EP-A 427 529、EP-A 451 878、WO In 03/18810 and WO 03/52073.Produce the method for these genetically modified plants generally to this area Those of skill in the art are known and are such as described in above-mentioned publication.These are contained in genetic modification and plant Insecticidal proteins in thing give the plant producing these albumen with on all taxonomy for arthropodan Insect, especially beetle (coleoptera (Coeleropta)), dipteral insect (Diptera (Diptera)) and Moth (Lepidoptera (Lepidoptera)) and the toleration of nematicide (Nematoda (Nematoda)).Can synthesize The genetically modified plant of one or more insecticidal proteins is such as described in above-mentioned publication, in them Some are commercially available, such as(producing the corn variety of toxin C ry1Ab), Plus (produces the corn variety of toxin C ry1Ab and Cry3Bb1),(produce toxin C ry9c Corn variety),RW (produces Cry34Ab1, Cry35Ab1 and enzyme phosphinothricin-N- The corn variety of Acetylase [PAT])；33B (produces the Cotton Gossypii of toxin C ry1Ac Kind),I (produces the cotton variety of toxin C ry1Ac),II (produces toxin The cotton variety of Cry1Ac and Cry2Ab2)；(producing the cotton variety of VIP toxin)；(producing the Rhizoma Solani tuber osi kind of toxin C ry3A)； Bt11 is (such asCB) and France The Bt176 (producing toxin C ry1Ab and the corn variety of PAT enzyme) of Syngenta Seeds SAS, The MIR604 of France Syngenta Seeds SAS (produces the Semen Maydis modifying translation of toxin C ry3A Kind, sees WO 03/018810), the MON 863 of Belgium Monsanto Europe S.A. (produces The corn variety of raw toxin C ry3Bb1), the IPC 531 of Belgium Monsanto Europe S.A. (produces The cotton variety modifying translation of raw toxin C ry1Ac) and Belgium Pioneer Overseas 1507 (the producing toxin C ry1F and the corn variety of PAT enzyme) of Corporation.
Additionally, also include by use recombinant DNA technology can synthesize one or more to antibacterial, The plant of the protein that virus or the resistance of fungal pathogens or toleration strengthen.The example of this albuminoid It is so-called " albumen relevant to pathogeny " (PR albumen, for example, see EP-A 0 392 225), Plant Genes Conferring Resistance To Pathogens (is such as expressed for from wild Mexican Rhizoma Solani tuber osi Solanum The resistant gene that the phytophthora infestans (Phytophthora infestans) of bulbocastanum works Rhizoma Solani tuber osi kind) or T4 Lysozyme (such as can synthesize and antibacterial such as Erwinia amylvora is had enhancing The Rhizoma Solani tuber osi kind of these albumen of resistance).Produce the method for these genetically modified plants generally to ability Territory those of skill in the art are known and are such as described in above-mentioned publication.
Additionally, also include by using recombinant DNA technology can synthesize one or more albumen to carry High yield (such as biomass generation, Grain Yield, content of starch, oil content or protein content), To arid, salt or the toleration of other growth limitation environmental factorss or to insect and fungus, antibacterial Or the plant of the toleration of viral pathogen.
Additionally, also include the content of material containing knots modification or new thing by use recombinant DNA technology Matter content especially to improve the mankind or zootrophic plant, such as, produces sanatory long-chain omega-3 The oil crop of fatty acid or unsaturated ω-9 fatty acid are (such asBrassica campestris L, Canada DOW Agro Sciences)。
Additionally, also include the content of material containing knots modification or new thing by use recombinant DNA technology Matter content especially to improve the plant of raw material production, such as, produces the Rhizoma Solani tuber osi (example of the amylopectin of increments AsRhizoma Solani tuber osi, Germany BASF SE).
Compound I and combinations thereof thing is particularly suitable for preventing and treating following plants disease respectively: ornamental plant, vegetable (such as white rust (A.candida)) and Helianthi (such as tragopogon pratensis l. white rust (A.tragopogonis)) On Albugo (Albugo) (white blister)；Vegetable, Brassica campestris L (the raw rod method (A.brassicola) of Semen Brassicae Campestris Or alternaria brassica (A.brassicae)), sugar beet (A.tenuis), fruit, rice, Semen sojae atricolor, soil Bean (such as early epidemic rod method (A.solani) or rod method (A.alternata)), Fructus Lycopersici esculenti (such as early epidemic chain Lattice spore or rod method) and Semen Tritici aestivi on Alternaria (Alternaria) (rod method leaf spot)；Sugar beet With the Aphanomyces (Aphanomyces) on vegetable；Ascochyta on Cereal and vegetable (Ascochyta), the such as A.tritici (anthrax) on Semen Tritici aestivi and the big wheat husk two spore (A. on Fructus Hordei Vulgaris hordei)；Bipolaris (Bipolaris) and Drechslera (Drechslera) (epigamous: rotation spore chamber Pseudomonas (Cochliobolus)), such as leaf spot on Semen Maydis (Bipolaris maydis (D.maydis) or Bipolaris zeicola (B.zeicola)), such as spot blight (the wheat root-rot Bipolaris (B. on Cereal Sorokiniana) the rice Bipolaris (B.oryzae) and on such as rice and lawn；Cereal is (the least Wheat or Fructus Hordei Vulgaris) on wheat powdery mildew (Blumeria (old name: Erysiphe) graminis) (powdery mildew)； Fruit and berry (such as Fructus Fragariae Ananssae), vegetable (such as Caulis et Folium Lactucae sativae, Radix Dauci Sativae, celeriac and Brassica oleracea L.var.capitata L.), Brassica campestris L, Botrytis cinerea (Botrytis cinerea) on flowers, vine, forest plants and Semen Tritici aestivi (epigamous: Botrytis cinerea (Botryotinia fuckeliana): gray mold)；Caulis et Folium Lactucae sativae dish on Caulis et Folium Lactucae sativae obstructs mould (Bremia Lactucae) (downy mildew)；Long beak shell on broad leaf tree and evergreen tree belongs to (Ceratocystis) (synonym line Mouth shell belongs to (Ophiostoma)) (canker or droop), such as the elm wilt (C. on elm Ulmi) (Dutch elm disease)；Semen Maydis (such as gray leaf spot: Semen Maydis tail spore bacterium (C.zeae-maydis)), rice, Sugar beet (such as Radix Betae raw tail spore (C.beticola)), Caulis Sacchari sinensis, vegetable, coffee, Semen sojae atricolor are (the biggest Bean Cercospora Sojina Hara (C.sojina) or Cercospora kikuchii (C.kikuchii)) and rice on Cercospora (Cercospora) (tail spore leaf spot)；Fructus Lycopersici esculenti (such as Cladosporium fulvum (C.fulvum): leaf mold) With the Cladosporium on Cereal (careless bud branch spore (C.herbarum) (ear rot) on such as Semen Tritici aestivi) (Cladosporium)；Clavicipitaceae (Claviceps purpurea) (ergot) on Cereal；Semen Maydis (ash The compacted spore of color length (C.carbonum)), Cereal (such as standing grain cochliobolus (C.sativus), phorozoon: Wheat root-rot Bipolaris) and rice (such as palace portion cochliobolus (C.miyabeanus), phorozoon: Oryza sativa L. Long compacted spore (H.oryzae)) on cochliobolus belong to (phorozoon: Helminthosporium (Helminthosporium) Or Bipolaris) (leaf spot)；Cotton Gossypii (such as cotton anthracnose bacterium (C.gossypii)), Semen Maydis (such as standing grain Raw anthrax bacteria (C.graminicola): anthrax stem rot), berry, Rhizoma Solani tuber osi (such as watermelon anthrax Bacterium (C.coccodes): diplostomiasis), Kidney bean (such as bean anthrax bacteria (C.lindemuthianum)) With Semen sojae atricolor (such as Colletotrichum truncatum (C.truncatum) or green soyabeans anthrax bacteria (C. Gloeosporioides) the perverse dish spore on) belongs to (Colletotrichum) (epigamous: GLOMERFLLA CINGULATA Pseudomonas (Glomerella)) (anthrax)；Corticium (Corticium), such as the wooden photovoltaicing leather bacteria (C. on rice Sasakii) (banded sclerotial blight)；Cucumber aphid (Corynespora on Semen sojae atricolor and ornamental plant Cassiicola) (leaf spot)；Rust staining pathogenic bacteria belongs to the C. on (Cycloconium), such as Chinese olive tree oleaginum；Fruit tree, vine (such as C.liriodendri, epigamous: Neonectria Liriodendri: Blackfoot Disease) and the raw Ramularia (Cylindrocarpon) of the Radix Ginseng viewed and admired on tree is (such as Fruit tree putrefaction disease or vine Blackfoot Disease, epigamous: Nectria (Nectria) or lady's slipper mycorhiza Pseudomonas (Neonectria))；Lineae ablicantes plumage bacterium (Dematophora (epigamous: Rosellinia) on Semen sojae atricolor Necatrix) (root rot/stem rot)；North stem canker Pseudomonas (Diaporthe), such as the Semen sojae atricolor on Semen sojae atricolor North stem canker (D.phaseolorum) (vertical withered infections)；Semen Maydis, Cereal such as Fructus Hordei Vulgaris (such as Fructus Hordei Vulgaris net The compacted spore of umbilicus (D.teres), net blotch in speckle) and Semen Tritici aestivi (such as D.tritici-repentis: brown spot), rice With Drechslera (synonym Helminthosporium, the epigamous: nuclear cavity Pseudomonas on lawn (Pyrenophora))；By Fuscoporia punctata(Fr.)Cum. (Formitiporia (synonym Phellinus) punctata), F. Mediterranea, Phaeomoniella chlamydospora (old entitled Phaeoacremonium Chlamydosporum), Phaeoacremonium aleophilum and/or Fructus Vitis viniferae seat chamber bacterium Eschka (Esca) on the vine that (Botryosphaeria obtusa) causes (do by vine droop Rot)；A kind of fruit, such as apple, pear, etc. (E.pyri), berry (Fructus Rubi Elsinochrome (E.veneta): anthrax) and vine Elsinoe (Elsinoe) on (Fructus Vitis viniferae Elsinochrome (E.ampelina): anthrax)；Rice on rice Leaf smut (Entyloma oryzae) (leaf smut)；Epicoccum (Epicoccum) on Semen Tritici aestivi is (black Fringe is sick)；Sugar beet (Radix Betae powdery mildew (E.betae)), vegetable (such as Semen Pisi sativi powdery mildew (E.pisi)) as Cucurbitaceous plant (such as two spore powdery mildews (E.cichoracearum)), Brassica oleracea L.var.capitata L., Brassica campestris L (such as E. Cruciferarum) Erysiphe (Erysiphe) (powdery mildew) on；Fruit tree, vine and view and admire on tree Side Curvularia lunata (Eutypa lata) (Eutypa Peptic Ulcers or droop, phorozoon: Cytosporina Lata, synonym Libertella blepharis)；Semen Maydis (such as Exserohilum turcicum (E.turcicum)) On prominent umbilicus Helminthosporium (Exserohilum) (synonym Helminthosporium)；Fusarium on various plants (Fusarium) (epigamous: Gibberella (Gibberella)) (droop, root rot or stem rot), such as Fusarium graminaria (F.graminearum) on Cereal (such as Semen Tritici aestivi or Fructus Hordei Vulgaris) or machete fusarium (F. Culmorum) (root rot, scab or silver point are sick), the sharp fusarium (F.oxysporum) on Fructus Lycopersici esculenti, (f.sp.glycines, present synonym is that north American soybean sudden death is combined to eggplant fusarium (F.solani) on Semen sojae atricolor Close disease pathogenic bacteria (F.virguliforme) and each cause the South America soybean sudden death syndrome of sudden death syndrome Wheel branch fusarium (F. on pathogenic bacteria (F.tucumaniae) and F.brasiliense and Semen Maydis verticillioides)；Gaeumannomyce on Cereal (such as Semen Tritici aestivi or Fructus Hordei Vulgaris) and Semen Maydis (Gaeumannomyces graminis) (full rot)；Cereal (such as Gibberella zeae (G.zeae)) With the Gibberella on rice (such as gibberella fujikuroi (G.fujikuroi): bakanae disease)；Vine, a kind of fruit, such as apple, pear, etc. and its Apple anthrax bacteria (Glomerella cingulata) on his plant and the cotton anthracnose bacterium on Cotton Gossypii (G.gossypii)；Grainstaining complex on rice；Black rot of grape bacterium on vine (Guignardia bidwellii) (black rot)；Rust on rosaceous plant and Juniperus oxycedrus (Gymnosporangium), the such as G.sabinae (rust) on pears；On Semen Maydis, Cereal and rice Helminthosporium (synonym Drechslera, epigamous: cochliobolus belong to)；Camel spore Rust (Hemileia), the such as coffee rust (H.vastatrix) (leaf of Semen Coffeae Arabicae rust) on coffee；Fructus Vitis viniferae Brown patch on rattan intends Isaria (Isariopsis clavispora) (synonym Cladosporium vitis)；Greatly Kidney bean shell ball spore (Macrophomina phaseolina (synonym phaseoli)) (root on bean and Cotton Gossypii Maize ear rot/stem rot)；(Microdochium is (same for the snow withered bacterium of mould leaf on Cereal (such as Semen Tritici aestivi or Fructus Hordei Vulgaris) Justice word Fusarium) nivale (snow mold)；Diffusion cross hair shell (Microsphaera on Semen sojae atricolor Diffusa) (powdery mildew)；On Monilia (Monilinia), such as drupe and other rosaceous plants Drupe chain sclerotinia sclerotiorum (M.laxa), Fructus Persicae brown rot fungus (M.fructicola) and M.fructigena (blossom rot and Branch maize ear rot, brown rot)；Mycosphaerella on Cereal, Fructus Musae, berry and Semen arachidis hypogaeae (Mycosphaerella), such as standing grain green-ball chamber bacterium (the M.graminicola) (phorozoon: little on Semen Tritici aestivi Wheat septoria musiva (Septoria tritici), septoria musiva leaf spot) or Fructus Musae on Fijian spherical cavity bacterium (M. Fijiensis) (Sigatoka melasma)；Brassica oleracea L.var.capitata L. (such as Semen Brassicae Campestris downy mildew (P.brassicae)), Brassica campestris L (example Such as Peronospora parasitic (P.parasitica)), Bulbus Allii Cepae (such as Herba Alii fistulosi downy mildew (P.destructor)), Nicotiana tabacum L. (Nicotiana tabacum L. Downy mildew (P.tabacina)) and Semen sojae atricolor (such as downy mildew bacterium (P.manshurica)) on Peronospora (Peronospora) (downy mildew)；Phakopsora pachyrhizi (Phakopsora pachyrhizi) on Semen sojae atricolor and mountain Horseleech layer rest fungus (P.Meibomiae) (soybean rust)；Such as vine (such as P.Tracheiphila and P.tetraspora) the Saksenaea vasiformis bacterium and on Semen sojae atricolor (such as brown stem rot bacterium (P.gregata): stem disease evil) Belong to (Phialophora)；Black shin Phoma sp (Phoma lingam) on Brassica campestris L and Brassica oleracea L.var.capitata L. (root rot and Stem rot) and sugar beet on Radix Betae Phoma sp (P.betae) (root rot, leaf spot and vertical withered infections)； Helianthi, vine (such as black rot of grape bacterium (P.viticola): dead arm and leaf spot) and Semen sojae atricolor (example Such as stem rot: P.phaseoli, epigamous: Semen sojae atricolor north stem canker (Diaporthe phaseolorum)) On Phomopsis (Phomopsis)；Maize brown spot bacterium (Physoderma on Semen Maydis Maydis) (brown spot)；Various plants such as green pepper and cucurbitaceous plant (such as Phytophthora capsici (P. Capsici)), Semen sojae atricolor (such as soybean phytophthora (P.megasperma), synonym P.sojae), Rhizoma Solani tuber osi and Fructus Lycopersici esculenti (such as phytophthora infestans (P.infestans): late blight) and broad leaf tree (such as robur sudden death pathogen (P. Ramorum) Phytophthora (Phytophthora) (droop, root rot, the leaf on: Oak Tree sudden death is sick) Maize ear rot, stem rot and fruit tree putrefaction disease)；Semen Brassicae Campestris on Brassica oleracea L.var.capitata L., Brassica campestris L, Radix Raphani and other plant Plasmodiophora brassicae (Plasmodiophora brassicae) (clubroot)；Peronospora (Plasmopara), such as Portugal This list of Hall on the raw single shaft mould (P.viticola) (vine downy mildew) of Fructus Vitis viniferae on grape rattan and Helianthi Axle mould (P.halstedii)；Podosphaera on rosaceous plant, Flos lupuli (Flos Humuli Lupuli), a kind of fruit, such as apple, pear, etc. and berry (Podosphaera) the apple mildew bacterium (P.leucotricha) in (powdery mildew), such as Fructus Mali pumilae；Such as Cereal such as Fructus Hordei Vulgaris and Semen Tritici aestivi (Polymyxa Graminis (P.graminis)) and sugar beet (Polymyxa betae (P.betae) the many Acarasiales on) belong to (Polymyxa) and the virus disease thus propagated；Cereal is the least Semen Tritici aestivi Phyllostachys pubescens (Pseudocercosporella herpotrichoides) (eye speckle on wheat or Fructus Hordei Vulgaris Disease, epigamous: Tapesia yallundae)；Pseudoperonospora on various plants (Pseudoperonospora) Pseudoperonospora cubensis (P. in (downy mildew), such as cucurbitaceous plant Cubensis) the false frost (P.humili) of grass or on Flos lupuli (Flos Humuli Lupuli)；Pseudopezicula on vine Tracheiphila (Fructus Vitis viniferae angle variegated leaf Jiao pathogenic bacteria or ' rotbrenner ', phorozoon: Saksenaea (Phialophora))；Puccinia (Puccinia) (rust) on various plants, such as Cereal is the least Semen Tritici aestivi handle rest fungus (P.triticina) (leaf rust or leaf rust) on wheat, Fructus Hordei Vulgaris or rye (Secale cereale L.), bar shaped handle becomes rusty Sick (P.striiformis) (stripe disease or yellow rust), (Fructus Hordei Vulgaris yellow dwarf's leaf becomes rusty Fructus Hordei Vulgaris handle rust (P.hordei) Sick), puccinia graminis (P.graminis) (stem rot or stalk rust) or puccinia triticinia (P. Recondita) (leaf rust or leaf rust), the P.kuehnii (orange rust) on Caulis Sacchari sinensis and the Tianmen on Germinatus Phragmitis Winter belongs to handle rust (P.asparagi)；(Pyrenophora is (asexual for Semen Tritici aestivi yellow blothch bacterium on Semen Tritici aestivi Type: Drechslera) tritici-repentis) umbilicus compacted spore (P. in Fructus Hordei Vulgaris filigree on (maculopathy) or Fructus Hordei Vulgaris Teres) (net blotch)；Pyricularia Sacc. (Pyricularia), such as the Pyricularia oryzae (P.oryzae) on rice is (sexual Type: Magnaporthe grisea, rice blast) and lawn and Cereal on piricularia oryzae (P. grisea)；Lawn, rice, Semen Maydis, Semen Tritici aestivi, Cotton Gossypii, Brassica campestris L, Helianthi, Semen sojae atricolor, sugar beet, Vegetable and various other plant (such as Pythium ultimum bacterium (P.ultimum) or the mould (P. of melon and fruit corruption Aphanidermatum) pythium (Pythium) (damping-off) on)；Ramularia (Ramularia), Sweet on such as R.collo-cygni (post is every spore leaf spot, physiology leaf spot) on Fructus Hordei Vulgaris and sugar beet Dish leaf spot fungi (R.Beticola)；Cotton Gossypii, rice, Rhizoma Solani tuber osi, lawn, Semen Maydis, Brassica campestris L, Rhizoma Solani tuber osi, sugar Rhizoctonia (Rhizoctonia) on garden beet, vegetable and various other plant, such as on Semen sojae atricolor Rhizoctonia solani Kuhn (R.solani) (root rot/stem rot), R.solani (banded sclerotial blight) on rice or Semen Tritici aestivi or Rhizoctonia cerealis (R.Cerealis) (wheat sharp eyespot) on Fructus Hordei Vulgaris；Fructus Fragariae Ananssae, Radix Dauci Sativae, Brassica oleracea L.var.capitata L., Rhizopus stolonifer (Rhizopus stolonifer) (black points, soft rot) on vine and Fructus Lycopersici esculenti；Greatly Rye (Secale cereale L.) beak spore (Rhynchosporium secalis) (leaf spot) on wheat, rye (Secale cereale L.) and Triticale hexaploide Lart.；On rice Rice broom branch mould (Sarocladium oryzae) and S.attenuatum (sheath rot disease)；Vegetable is with big Field crop such as Brassica campestris L, Helianthi (such as sclerotinite (S.sclerotiorum)) and Semen sojae atricolor (such as S.rolfsii Or soybean sclerotinia crown rot (S.sclerotiorum)) on Sclerotinia (Sclerotinia) (stem rot or white thin,tough silk Sick)；Septoria (Septoria) on various plants, such as the Semen sojae atricolor septoria musiva (S. on Semen sojae atricolor Glycines) (brown spot), the wheat septoria (S.tritici) (septoria musiva leaf spot) on Semen Tritici aestivi and Cereal On the grain husk many spores of withered shell (S. (synonym Stagonospora) nodorum) (spot blight)；On vine Fructus Vitis viniferae snag shell (Uncinula (synonym Erysiphe) necator) (powdery mildew, phorozoon: Oidium tuckeri)；Semen Maydis (such as Exserohilum turcicum (S.turcicum), synonym big speckle Exserohilum (Helminthosporium turcicum)) and lawn on leaf blight Pseudomonas (Setosphaeria) (leaf is withered Sick)；Axle on Semen Maydis (such as silk axle smut (S.reiliana): head smut), Semen setariae and Caulis Sacchari sinensis is black Powder Pseudomonas (Sphacelotheca) (smut)；Monofilament shell powdery mildew on cucurbitaceous plant (Sphaerotheca fuliginea) (powdery mildew)；Powder crust bacterium (Spongospora on Rhizoma Solani tuber osi Subterranea) (powdery scab) and the virus disease thus propagated；Stagonospora on Cereal (Stagonospora), such as the many spores of the withered shell of grain husk (S.nodorum) on Semen Tritici aestivi (spot blight, epigamous: The withered spherical cavity bacterium of grain husk (Leptosphaeria [synonym Phaeosphaeria] nodorum))；Horse on Rhizoma Solani tuber osi Bell potato cancerous protuberance pathogenic bacteria (Synchytrium endobioticum) (Rhizoma Solani tuber osi canker)；Exoascus (Taphrina), such as outside the lopsided external capsule bacterium (T.Deformans) (leaf-curl) in Fructus Persicae and Lee on Lee Capsule bacterium (T.pruni) (cystocarp Lee)；Thiclaviopsis on Nicotiana tabacum L., core fruits and vegetables, Semen sojae atricolor and Cotton Gossypii (Thielaviopsis) (black root rot), such as black root rot bacterium (T.basicola) (synonym Chalara elegans)；Tilletia (Tilletia) (bunt or light bunt on Cereal Sick), such as the T.tritici (synonym T.caries, the bunt of wheat) on Semen Tritici aestivi and T. Controversa (dwarf bunt)；Meat spore core coral bacterium (Typhula on Fructus Hordei Vulgaris or Semen Tritici aestivi Incarnata) (ash snow mold)；Ustilago (Urocystis), such as the hidden bar smut (U. on rye (Secale cereale L.) Occulta) (bar smut)；Vegetable such as Kidney bean (such as wart top uromyce (U.appendiculatus), Synonym U.phaseoli) and sugar beet (such as rust of beet (U.betae)) on monospore rust belong to (Uromyces) (rust)；Cereal (such as wheat loose smut (U.nuda) and U.avaenae), Semen Maydis Ustilago on (such as Ustilago maydis (U.maydis): smut of maize) and Caulis Sacchari sinensis (Ustilago) (smut)；Black star bacterium on Fructus Mali pumilae (such as scab of apple (V.inaequalis)) and pears Belong to (Venturia) (scab)；And various plant if tree and view and admire tree, vine, berry, vegetables Verticillium (Verticillium) (droop) on dish and field crop, such as Fructus Fragariae Ananssae, Brassica campestris L, Rhizoma Solani tuber osi With the Verticillium wilt (V.dahliae) on Fructus Lycopersici esculenti.
Compound I and combinations thereof thing respectively be also suitable for store product or results product protection in and Harmful fungoid is prevented and treated in material protection.
Term " material protection " is understood to mean that safeguard industries and nonliving material, as binding agent, Glue, timber, paper and cardboard, textile, leather, paint dispersion, plastics, cooling lubricant, Fiber or fabric are in case harmful microorganism such as fungus and bacteria attack and destruction.For timber and other materials The protection of material, especially it should be noted that following harmful fungoid: Ascomycetes fungus, such as line mouth shell belong to, long Beak shell belongs to, Aureobasidium pullulans (Aureobasidium pullulans), Sclerophoma spp., hair shell Belonging to (Chaetomium spp.), Humicola (Humicola spp.), Peter's shell belongs to (Petriella spp.), The mould genus of pieces (Trichurus spp.)；Basidiomycetes fungus, such as cellar fungus belong to (Coniophora Spp.), Coriolus Qu61 (Coriolus spp.), viscous gill fungus belongs to (Gloeophyllum spp.), Lentinus (Lentinus spp.), pleurotus (Pleurotus spp.), sleeping hole belongs to (Poria spp.), Merulius (Serpula spp.) and Tyromyces (Tyromyces spp.), deuteromycetes fungus, such as aspergillus (Aspergillus spp.), Cladosporium, Penicillium (Penicillium spp.), trichoderma (Trichoderma Spp.), Alternaria, paecilomyces (Paecilomyces spp.) and Zygomycetes (Zygomycetes) Fungus, such as mucor (Mucor spp.), should note in the protection of this external storage product and results product Row yeast fungus in the mind: mycocandida (Candida spp.) and saccharomyces cerevisiae (Saccharomyces cerevisae)。
Processing method of the present invention can be also used for protection and stores product or results product with anti-fungal and micro-life In the field of thing invasion and attack.According to the present invention, term " storage product " is understood to mean that plant or dynamic The natural materials in thing source and form processing thereof, they are taken from the natural life cycle and wish digital preservation. The storage product such as plant in crops source or its part, such as stem, leaf, tuber, seed, fruit Grain can with fresh harvest state or with form processing protect, as predrying, moistening, pulverizing, Grinding, squeeze or bakee, the method also is known as gathering in the crops post processing.Also fall under storage Product Definition Be timber, either unmanufactured wood form, such as building timber, electric wire tower and fence, or become Product form, such as wood furniture or article.The storage product of animal origin be rawhide, leather, fur, Hair etc..The combination of the present invention is possible to prevent disadvantageous effect such as corrupt, variable color or to go mouldy.Preferably " storage Deposit product " be understood to mean that natural materials and the form processing thereof of plant origin, more preferably fruit and Its form processing, such as a kind of fruit, such as apple, pear, etc., drupe, berry and citrus fruit and form processing thereof.
Compound I and combinations thereof thing may be used for improving plant health respectively.The invention still further relates to a kind of logical Cross and process plant, its propagating materials with the compound I of effective dose and combinations thereof thing respectively and/or wherein plant The method that thing grows place to be grown and improves plant health.
Term " plant health " is understood to mean that plant and/or its product are by several signs such as yield (example As increase Biomass and/or the valuable components content of increase), the plant vigor (plant such as improved Growth and/or greener leaf (" greening effect ")), quality (the improvement content of such as some composition or Composition) and the toleration of non-life and/or life stress individually or is mutually combined the situation determined.Plant The above-mentioned sign of thing health status maybe can be able to influence each other with mutual dependence for existence.
Compound of formula I can exist with the possible different different crystal forms of its biologic activity.They are similarly Subject of the present invention.
Compound I is directly or with composition forms by processing very with the active substance of effective fungicidal amount Bacterium or need plant, plant propagation material such as seed, soil, surface, the material preventing fungus from attacking Or space and use.Using can be at plant, plant propagation material such as seed, soil, surface, material Material or space are carried out before and after fungal infection.
Plant propagation material can when planting or transplant or before plantation or transplanting with compound I originally Body or the compositions comprising at least one compound I prophylactically process.
The invention still further relates to the agriculture chemistry combination comprising auxiliary agent and at least one the compounds of this invention I Thing.
Agrochemical composition comprises the compound I of effective fungicidal amount.Term " effective dose " represents Be enough on cultivated plant or in material protection, prevent and treat harmful fungoid and processed plant is not caused aobvious Write the present composition or the compound I of the amount of infringement.This amount can change in a wide range and depend on In various factors fungus kind, processed cultivated plant or material to be prevented and treated, weather conditions with And particular compound I used.
Compound I, its N-oxide and salt can change into the type that agrochemical composition is conventional, Such as solution, emulsion, suspension, powder, powder, paste, granule, mould, capsule and mixed Compound.The example of types of compositions is suspension (such as SC, OD, FS), emulsifiable concentrate (example Such as EC), emulsion (such as EW, EO, ES, ME), capsule (such as CS, ZC), stick with paste, lozenge, Wettable powder or powder (such as WP, SP, WS, DP, DS), mould (such as BR, TB, DT), granule (such as WG, SG, GR, FG, GG, MG), insect killing product (such as LN) with And process the gel formulation (such as GF) of plant propagation material such as seed.These and other combine species Type is at " Catalogue of pesticide formulation types and international coding System ", Technical Monograph, the 2nd phase, May in 2008 the 6th edition, CropLife International is defined.
Compositions such as Mollet and Grubemann, Formulation technology, Wiley VCH, Weinheim, 2001；Or Knowles, New developments in crop protection Product formulation, Agrow Reports DS243, T&F Informa, London, 2005 Described prepare in a known way.
Suitably auxiliary agent is solvent, liquid-carrier, solid carrier or filler, surfactant, dispersion Agent, emulsifying agent, wetting agent, adjuvant, solubilizer, penetration enhancer, protective colloid, adhere to Agent, thickening agent, wetting agent, expellent, attractant, feeding stimulants, compatilizer, antibacterial, Antifreezing agent, defoamer, coloring agent, viscosifier and binding agent.
Suitably solvent and liquid-carrier are water and organic solvent, as in high boiling mineral oil fractions, Such as kerosene, diesel oil；Plant or the oil of animal origin；Aliphatic, ring-type and aromatic hydrocarbons, such as first Benzene, paraffin, naphthane, alkylated naphthalene；Alcohols, such as ethanol, propanol, butanol, benzylalcohol, hexamethylene Alcohol；Glycols；DMSO；Ketone, such as Ketohexamethylene；Esters, such as lactate, carbonic ester, Fatty acid ester, gamma-butyrolacton；Fatty acid；Phosphonate ester；Amine；Amide-type, such as N-methylpyrrole Alkanone, fatty acid dimethylamides；And their mixture.
Suitably solid carrier or filler is ore deposit soil, such as silicate, silica gel, Talcum, Kaolin, Limestone, Calx, Chalk, clay, dolomite, kieselguhr, bentonite, calcium sulfate, magnesium sulfate, Magnesium oxide；Polysaccharide, such as cellulose, starch；Fertilizer, such as ammonium sulfate, ammonium phosphate, ammonium nitrate, Ureas；The product of plant origin, such as flour, bark powder, wood powder and shuck powder, and they Mixture.
Suitably surfactant is surfactant, such as anion, cation, nonionic and two Property surfactant, block polymer, polyelectrolyte, and their mixture.Live in such surface Property agent can serve as emulsifying agent, dispersant, solubilizer, wetting agent, penetration enhancer, protectiveness glue Body or adjuvant.The example of surfactant is listed in McCutcheon ' s, and volume 1: Emulsifiers &Detergents, McCutcheon ' s Directories, Glen Rock, USA, In 2008 (International Ed. or North American Ed.).
Suitably anion surfactant is sulfonic acid, sulphuric acid, phosphoric acid, the alkali metal of carboxylic acid, alkaline earth Metal or ammonium salt and their mixture.The example of sulfonate is alkylaryl sulfonates, diphenyl The sulfonate of sulfonate, alpha-alkene sulfonate, lignosulphonates, fatty acid and oil, ethoxylation alkane The sulfonate of base phenol, the sulfonate of alkoxylate aryl phenol, the condensation sulfonate of naphthalene, dodecyl- The sulfonate of sulfonate, naphthalene and alkylnaphthalene, sulfosuccinate or sulfosuccinic with Detergent Alkylate 5 Amide hydrochlorate.The example of sulfate be fatty acid and oil sulfate, the sulfate of ethoxylated alkylphenol, The sulfate of alcohol, the sulfate of ethoxylated alcohol or the sulfate of fatty acid ester.Phosphatic example is phosphorus Hydrochlorate ester.The example of carboxylate is alkyl carboxylate and carboxylation alcohol or alkylphenol ethoxylate.
Suitably nonionic surfactant is alcoxylates, the substituted fatty acid amide of N-, amine oxygen Compound, esters, glycosyl surfactant active, polymeric surfactant and mixture thereof.Alkoxylate The example of thing is the alcohol of all equivalent alkoxylates of 1-50 such as has already been, alkyl phenol, amine, amide, aryl The compound of phenol, fatty acid or fatty acid ester.Ethylene oxide and/or propylene oxide can be used for alcoxyl Base, preferential oxidation ethylene.The example of the substituted fatty acid amide of N-is fatty acid glucamides or fat Fat acid alkanolamide.The example of esters is fatty acid ester, glyceride or monoglyceride.Glycosyl surface The example of activating agent is anhydro sorbitol, ethoxylated sorbitan, sucrose and glucose ester or alkane Base polyglucoside.The example of polymeric surfactant is vinyl pyrrolidone, vinyl alcohol or acetic acid The homopolymer of vinyl acetate or copolymer.
Suitably cationic surfactant is season type surfactant, such as, have 1 or 2 hydrophobicity The quaternary ammonium compound of group, or the salt of long chain primary amines.Suitably amphoteric surfactant is alkyl betaine And imidazolines.Suitably block polymer is the A-B of the block comprising polyoxyethylene and polyoxypropylene Or A-B-A type block polymer, or comprise the A-B-C of alkanol, polyoxyethylene and polyoxypropylene Type block polymer.Suitably polyelectrolyte is polyacids or polybases.The example of polyacids is polyacrylic Alkali metal salt or polyacids comb-shaped polymer.The example of polybases is polyvinylamine or polyvinylamine.
Suitably adjuvant is itself to have insignificant pesticide activity or own even without pesticide work Property and improve the compound I compound to the biology performance of object.Example is surfactant, Mineral oil or vegetable oil and other auxiliary agents.Other examples are by Knowles, Adjuvants and Additives, Agrow Reports DS256, T&F Informa UK, the 2006, the 5th chapter is listed.
Suitably thickening agent is that polysaccharide (such as xanthan gum, carboxymethyl cellulose), inorganic clay (organic change Property or unmodified), polycarboxylate and silicate.
Suitably antibacterial is bronopol and isothiazolinone derivatives such as alkyl isothiazole quinoline ketone and benzo Isothiazolone.
Suitably antifreezing agent is ethylene glycol, propylene glycol, carbamide and glycerol.
Suitably defoamer is polysiloxanes, long-chain alcohol and soap.
Suitably coloring agent (such as red coloration, blueness or green) is low aqueous solubility pigment and water solublity dye Material.Example is inorganic colourant (such as ferrum oxide, titanium oxide, Hexacyanoferrate ferrum) and organic coloring Agent (such as alizarin coloring agent, azo colouring agent and phthalocyanine colorant).
Suitably viscosifier or binding agent be polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol, Polyacrylate, biowax or synthetic wax and cellulose ether.
The example of types of compositions and preparation thereof is:
I) water-soluble concentrate (SL, LS)
By molten to 10-60 weight % compound I and 5-15 weight % wetting agent (such as alcohol alkoxylates) In the water adding to 100 weight % and/or water-soluble solvent (such as alcohol).Active substance is at dilute with water Time dissolve.
Ii) dispersibility concentrate (DC)
By molten to 5-25 weight % compound I and 1-10 weight % dispersant (such as polyvinylpyrrolidone) In the organic solvent (such as Ketohexamethylene) adding to 100 weight %.Dilute with water obtains dispersion.
Iii) emulsifiable concentrate (EC)
By 15-70 weight % compound I and 5-10 weight % emulsifying agent (such as calcium dodecyl benzene sulfonate And castor oil ethoxylate) it is dissolved in water-insoluble organic solvents (the such as aromatics adding to 100 weight % Hydrocarbon) in.Dilute with water obtains emulsion.
Iv) emulsion (EW, EO, ES)
By 5-40 weight % compound I and 1-10 weight % emulsifying agent (such as calcium dodecyl benzene sulfonate And castor oil ethoxylate) be dissolved in 20-40 weight % water-insoluble organic solvents (such as aromatic hydrocarbon). By mulser this mixture introduced and add in the water of 100 weight % and make equal phase emulsion.Use water Dilution obtains emulsion.
V) suspension (SC, OD, FS)
In the ball mill of stirring, 20-60 weight % compound I is being added 2-10 weight % dispersant With wetting agent (such as sodium lignosulfonate and alcohol ethoxylate), 0.1-2 weight % thickening agent (such as xanthan Glue) and add to the pulverizing under water of 100 weight %, obtain active substance suspension in small, broken bits.Dilute with water obtains To stable active substance suspension.At most 40 weight % binding agents are added for FS type of composition (such as polyvinyl alcohol).
Vi) water-dispersible granule and water-soluble granular (WG, SG)
Adding to dispersant and wetting agent (the such as sodium lignosulfonate and alcohol ethoxy of 100 weight % Compound) under fine gtinding 50-80 weight % compound I by commercial plant (such as extruder, spraying Tower, fluid bed) it is made into water dispersible or water-soluble granular.Dilute with water obtains stable active matter Matter dispersion or solution.
Vii) water dispersible pow-ders and water-soluble powder (WP, SP, WS)
By 50-80 weight % compound I add 1-5 weight % dispersant (such as sodium lignosulfonate), 1-3 weight % wetting agent (such as alcohol ethoxylate) and add to the solid carrier of 100 weight % (such as Silica gel) under in rotor-stator grinding machine grind.Dilute with water obtain stable active substance dispersion or Solution.
Viii) gel (GW, GF)
3-10 weight % dispersant (such as sodium lignosulfonate), 1-5 is being added in the ball mill of stirring Weight % thickening agent (such as carboxymethyl cellulose) and add to the 5-25 weight of pulverizing under water of 100 weight % % compound I, obtains the delicate suspensions of active substance.Dilute with water obtains stable active substance Suspension.
Ix) microemulsion (ME)
5-20 weight % compound I is added 5-30 weight % organic solvent blend (such as fatty acid Dimethylformamide and Ketohexamethylene), 10-25 weight % surfactant blend (such as alcohol ethoxylate With aryl phenol ethoxylate) and add in the water of 100 weight %.This mixture is stirred 1 hour, With the thermodynamically stable microemulsion of spontaneous generation.
X) microcapsule (CS)
5-50 weight % compound I, 0-40 weight % water-insoluble organic solvents (such as aromatics will be comprised Hydrocarbon), 2-15 weight % acrylic monomer (such as methyl methacrylate, methacrylic acid and two-or Triacrylate) oil phase be distributed in the aqueous solution of protective colloid (such as polyvinyl alcohol).Free radical Polymerization results in poly-(methyl) acrylate microcapsule.Or 5-50 weight % of the present inventionization will be comprised Compound I, 0-40 weight % water-insoluble organic solvents (such as aromatic hydrocarbon) and isocyanate-monomer is (such as Diphenyl methane-4,4 '-diisocyanate) oil phase be distributed to protective colloid (such as polyvinyl alcohol) In aqueous solution.Add polyamines (such as hexamethylene diamine) and result in polyurea microcapsule.Amount of monomer is 1-10 weight %.Weight % relates to whole CS compositions.
Xi) can dusting powder (DP, DS)
By 1-10 weight % compound I grinding in small, broken bits and with add to the solid carrier of 100 weight % (such as Kaolin in small, broken bits) it is sufficiently mixed.
Xii) granule (GR, FG)
0.5-30 weight % compound I grinding in small, broken bits combination are added to the solid carrier of 100 weight % (such as silicate).Pelletize is realized by extrusion, spray drying or fluid bed.
Xiii) ultra low volume liquids (UL)
1-50 weight % compound I is dissolved in the organic solvent (such as aromatic hydrocarbon) adding to 100 weight % In.
Types of compositions i)-xiii) can optionally comprise other auxiliary agents, such as 0.1-1 weight % antibacterial, 5-15 Weight % antifreezing agent, 0.1-1 weight % defoamer and 0.1-1 weight % coloring agent.
Agrochemical composition generally comprises 0.01-95 weight %, preferably 0.1-90 weight %, especially It it is 0.5-75 weight % active substance.Active substance is with the purity (root of 90-100%, preferably 95-100% According to NMR spectra) use.
In order to process plant propagation material, especially seed, generally use seed treatment with solution (LS), Suspension emulsion (SE), flowable concentrate (FS), dry-cure powder (DS), slurry treatment moisture Dissipate property powder (WS), water-soluble powder (SS), emulsion (ES), emulsifiable concentrate (EC) and gel (GF). Described compositions provides 0.01-60 weight %, preferably 0.1-40 in preparation in sight after dilution 2-10 times The active material concentration of weight %.Using can before planting or period is carried out.Compound I and The compositions application process on plant propagation material, especially seed respectively include seed dressing, coating, Application process in pelletize, dusting and immersion and ditch dug with a plow.Preferably by the method not inducing sprouting, example As numerous in compound I or a combination thereof thing being applied to plant respectively by seed dressing, pelletize, coating and dusting Grow on material.
When in plant protection, the amount of application of active substance depends on that the kind of desirable effect is 0.001-2kg/ha, preferably 0.005-2kg/ha, more preferably 0.05-0.9kg/ha, especially 0.1-0.75kg/ha。
At plant propagation material such as seed such as by dusting, coating or the process being impregnated with seed, logical The amount often requiring active substance is 0.1-1000g/100kg, preferably 1-1000g/100kg, more preferably 1-100g/100kg, most preferably 5-100g/100kg plant propagation material (preferred seed).
When being used for protecting material or storing in product, the amount of application of active substance depends on using region Kind and desirable effect.Amount of application for example, 0.001g-2kg conventional in material protection, preferably 0.005g-1kg active substance/cubic meter processed material.
Can to active substance or comprise in combinations thereof thing as pre-composition add or properly (bucket mixing) various types of oil, wetting agent, adjuvant, fertilizer or micro-battalion is added just before use tight Support element and other pesticide (such as herbicide, insecticide, antifungal, growth regulator, safener, Biological pesticide).These reagent can with 1:100-100:1, the weight ratio of preferably 1:10-10:1 with this Bright compositions mixes.
Pesticide generally by its effect by nuisance prevention, anergy, kill or baffle in other respects Chemistry or biological agent (the harmful active component that such as goes out, compound, compositions, virus, antibacterial, antibacterial Agent or disinfectant).Objective pests can include destroying property, cause trouble, spreads disease or for disease The sick insecticide of vector, phytopathogen, weeds, Mollusca, birds, mammal, fish Class, nematicide (ascarid) and microorganism.Term pesticide also include change plant expection growth, bloom or The plant growth regulator of reproduction rate；Cause the defoliant that leaf or other leaveves come off from plant, this Generally promote results；Promote biological tissue, the desiccant being dried such as undesirable aboveground vegetation part； Activation plant physiology function is to defend the plant activator of some nuisance；Reduce pesticide to crops It is not intended to the safener of herbicide effect；And affect plant physiology function to strengthen plant growing, biology The plant growth promoter of any other mass parameter of the yielding product of matter, yield or crops.
Biological pesticide is defined as based on microorganism (antibacterial, fungus, virus, nematicide etc.) or sky So product (compound, as metabolite, protein or from biological or the extract of other natural sources) Pesticide form (U.S.Environmental Protection Agency: http://www.epa.gov/pesticides/biopesticides/)。
Biological pesticide is generally by native organism and/or its metabolite, including antibacterial and other micro-lifes The growths such as thing, fungus, virus, nematicide, protein and concentration and produce.They are typically considered The important component that nuisance comprehensive control (IPM) is planned.
Biological pesticide is broadly divided into two classes, i.e. microbial pesticide and biochemical pesticides:
(1) microbial pesticide is made up of antibacterial, fungus or virus and (and generally includes antibacterial and fungus and produce Metabolite).Entomopathogenic nematode is also microbial pesticide by the mankind, although they are cellulous.
(2) biochemical pesticides is preventing and treating nuisance or provides other crop protections as defined below to use On the way, the natural materials but to mammal relative nontoxic.
User generally the present composition is used for predose device, musette bag aerosol apparatus, aerosol can, Spraying airplane or irrigation system.Here by this agrochemical composition water, buffer agent and/or other help Agent is formulated into required application concentration, thus obtains i.e. with spray liquid or agrochemical composition of the present invention. Per hectare agricultural use district generally uses 20-2000 liter, and preferably 50-400 rises and i.e. uses spray liquid.
According to an embodiment, user can be used for using at aerosol can or any other kind with oneself Container (such as seed treatment rotary drum, pellet seeds machine, musette bag aerosol apparatus) in mixing of the present invention group Each component of compound, each several part of such as packaging kit or binary or each several part of ternary mixture and Properly can add other auxiliary agents.
Work as living microorganism, as selected from L1), L3) and the L5) pesticide organized, form this packaging kit Time a part of, it is necessary to the selection of careful is each component (such as chemical pesticide reagent) and other auxiliary agents and Amount should not affect the vigor of microbial pesticide in the compositions mixed by user.Particularly with antibacterial and Solvent, it is necessary to consider the compatibility with corresponding microorganism pesticide.
Therefore, one embodiment of the invention is a kind of packaging kit preparing useful composition pesticide, This packaging kit comprises and a) comprises component 1 defined herein) and the compositions of at least one auxiliary agent； And b) comprise component 2 defined herein) and the compositions of at least one auxiliary agent；And c) wrap Containing at least one auxiliary agent and another active component 3 the most defined herein) compositions.
By compound I or comprise combinations thereof thing with the type of service of antifungal and other antifungals Agent mixing is widened Fungicidally active spectrum in many cases or prevents the drug-fast generation of antifungal.This Outward, synergistic function is obtained in many cases.
Following pesticide II (the such as pesticidal active substance and biological agriculture that compound I can be used therewith Medicine) it is used for possible combination is described, but it is not intended to them:
A) respiration inhibitor
The coordination compound III inhibitor (such as strobilurins class) in-Qo site: nitrile Fluoxastrobin (azoxystrobin) (A.1.1), Turbo cornutus Solander bacterium ester (coumethoxystrobin) (A.1.2), SYP-3375 (coumoxystrobin) (A.1.3), dimoxystrobin (dimoxystrobin) (A.1.4), Enestroburin (enestroburin) (A.1.5), alkene oxime amine (fenaminstrobin) (A.1.6), fenoxystrobin/ Fluorine bacterium demodicid mite ester (flufenoxystrobin) (A.1.7), fluoxastrobin (fluoxastrobin) (A.1.8), Asia Amine bacterium (kresoxim-methyl) (A.1.9), mandestrobin (A.1.10), fork phenalgin amide (metominostrobin) (A.1.11), orysastrobin (orysastrobin) (A.1.12), ZEN 90160 (picoxystrobin) (A.1.13), pyraclostrobin (pyraclostrobin) (A.1.14), Pyrametostrobin (A.1.15), pyraoxystrobin (pyraoxystrobin) (A.1.16), trifloxystrobin (trifloxystrobin) (A.1.17) and 2-(2-(3-(2,6-Dichlorobenzene base)-1-methyl acrol amino oxygen Methyl) phenyl)-2-methoxyimino-N-methylacetamide (A.1.18), pyribencarb (A.1.19), triclopyricarb/chlorodincarb(A.1.20)、Famoxadone (famoxadone) (A.1.21), Fenamidone (fenamidone) (A.1.21)；N-[2-[(1,4-dimethyl-5-Phenylpyrazole-3-base) epoxide Methyl] phenyl]-N-methoxy carbamate methyl ester (A.1.22), 1-[the chloro-2-of 3-[[1-(4-chlorobenzene Base)-1H-pyrazole-3-yl] epoxide methyl] phenyl]-4-methyl tetrazolium-5-ketone (A.1.23), 1-[3-bromine -2-[[1-(4-chlorphenyl) pyrazole-3-yl] epoxide methyl] phenyl]-4-methyl tetrazolium-5-ketone (A.1.24), 1-[2-[[1-(4-chlorphenyl) pyrazole-3-yl] epoxide methyl]-3-aminomethyl phenyl]-4-methyl tetrazolium-5-ketone (A.1.25), 1-[2-[[1-(4-chlorphenyl) pyrazole-3-yl] epoxide methyl]-3-fluorophenyl]-4-methyl tetrazolium -5-ketone (A.1.26), 1-[2-[[1-(2,4-Dichlorobenzene base) pyrazole-3-yl] epoxide methyl]-3-fluorophenyl]-4- Methyl tetrazolium-5-ketone (A.1.27), 1-[2-[[4-(4-chlorphenyl) thiazol-2-yl] epoxide methyl]-3-methyl Phenyl]-4-methyl tetrazolium-5-ketone (A.1.28), 1-[the chloro-2-of 3-[[4-p-methylphenyl thiazol-2-yl] epoxide first Base] phenyl]-4-methyl tetrazolium-5-ketone (A.1.29), 1-[3-cyclopropyl-2-[[2-methyl-4-(1-methylpyrazole -3-base) phenoxy group] methyl] phenyl]-4-methyl tetrazolium-5-ketone (A.1.30), 1-[3-difluoro-methoxy -2-[[2-methyl-4-(1-methylpyrazole-3-base) phenoxy group] methyl] phenyl]-4-methyl tetrazolium-5-ketone (A.1.31), 1-methyl-4-[3-methyl-2-[[2-methyl-4-(1-methylpyrazole-3-base) phenoxy group] methyl] Phenyl] tetrazolium-5-ketone (A.1.32), 1-methyl-4-[3-methyl-2-[[the sub-second ammonia of 1-[3-trifluoromethyl] Base] epoxide methyl] phenyl] tetrazolium-5-ketone (A.1.33), (Z, 2E)-5-[1-(2,4-Dichlorobenzene base) pyrazoles-3- Base] epoxide-2-methoxyimino-N, 3-dimethyl-penten-3-enamine (A.1.34), (Z, 2E)-5-[1-(4-chlorobenzene Base) pyrazole-3-yl] epoxide-2-methoxyimino-N, 3-dimethyl-penten-3-enamine (A.1.35), (Z, 2E)-5-[1-(4-chloro-2-fluorophenyl) pyrazole-3-yl] epoxide-2-methoxyimino-N, 3-dimethyl-penten -3-enamine (A.1.36)；
The coordination compound III inhibitor in-Qi site: cyazofamid (cyazofamid) (A.2.1), Amisulbrom (A.2.2), 2 Methylpropionic acid [(3S, 6S, 7R, 8R)-8-benzyl-3-[(3-acetoxyl group-4- Methoxypyridine-2-carbonyl) amino]-6-methyl-4,9-dioxo-1,5-dioxy nonyl ring-7-base] ester (A.2.3), 2 Methylpropionic acid [(3S, 6S, 7R, 8R)-8-benzyl-3-[[3-acetoxymethoxy-4-methoxy Yl pyridines-2-carbonyl] amino]-6-methyl-4,9-dioxo-1,5-dioxy nonyl ring-7-base] ester (A.2.4), 2- Methylpropanoic acid [(3S, 6S, 7R, 8R)-8-benzyl-3-[(3-isobutoxy carbonyloxy group-4-methoxypyridine-2- Carbonyl) amino]-6-methyl-4,9-dioxo-1,5-dioxy nonyl ring-7-base] ester (A.2.5), 2 Methylpropionic acid [(3S, 6S, 7R, 8R)-8-benzyl-3-[[3-(dioxane-5-ylmethoxy between 1,3-benzo)-4-methoxyl group pyrrole Pyridine-2-carbonyl] amino]-6-methyl-4,9-dioxo-1,5-dioxy nonyl ring-7-base] ester (A.2.6)；2-methyl Propanoic acid (3S, 6S, 7R, 8R)-3-[[(3-hydroxyl-4-methoxyl group-2-pyridine radicals) carbonyl] amino]-6-methyl -4,9-dioxo-8-(phenyl methyl)-1,5-dioxy nonyl ring-7-base ester (A.2.7), isopropylformic acid. (3S, 6S, 7R, 8R)-8-benzyl-3-[3-[(isobutyryl epoxide) methoxyl group]-4-methoxypyridine amide
Base]-6-methyl-4,9-dioxo-1,5-dioxy nonyl ring-7-base ester (A.2.8)；
-coordination compound II inhibitor (such as carboxyl acylamide): benodanil (benodanil) (A.3.1), Benzovindiflupyr (A.3.2), bixafen (A.3.3), Boscalid (boscalid) (A.3.4), wither Rust spirit (carboxin) (A.3.5), methuroxam (fenfuram) (A.3.6), fluopyram (fluopyram) (A.3.7), flutolanil (flutolanil) (A.3.8), fluxapyroxad (fluxapyroxad) (A.3.9), the spirit of furan pyrazoles (furametpyr) (A.3.10), isofetamid (A.3.11), go out embroidery amine (mepronil) (A.3.13), the oxidation of isopyrazam (A.3.12), the third oxygen is withered Rust spirit (oxycarboxin) (A.3.14), penflufen (A.3.14), pyrrole metsulfovax (penthiopyrad) (A.3.15), sedaxane (A.3.16), tecloftalam (tecloftalam) (A.3.17), thifluzamide (thifluzamide) (A.3.18), N-(4'-trifluoromethylthio biphenyl-2-base)-3-difluoromethyl-1-methyl -1H-pyrazole-4-carboxamide (A.3.19), N-(2-(1,3,3-trimethyl butyl) phenyl)-1,3-dimethyl-5- Fluoro-1H-pyrazole-4-carboxamide (A.3.20), 3-(difluoromethyl)-1-methyl-N-(1,1,3-trimethyl-2,3- Dihydroindene-4-base) pyrazole-4-carboxamide (A.3.21), 3-(trifluoromethyl)-1-methyl-N-(1,1,3-tri- Methyl-2,3-dihydroindene-4-base) pyrazole-4-carboxamide (A.3.22), 1,3-dimethyl-N-(1,1,3-tri- Methyl-2,3-dihydroindene-4-base) pyrazole-4-carboxamide (A.3.23), 3-(trifluoromethyl)-1,5-dimethyl -N-(1,1,3-trimethyl-2,3-dihydroindene-4-base) pyrazole-4-carboxamide (A.3.24), 1,3,5-trimethyl -N-(1,1,3-trimethyl-2,3-dihydroindene-4-base) pyrazole-4-carboxamide (A.3.25), N-(7-fluorine -1,1,3-trimethyl-2,3-dihydroindene-4-base)-1,3-Dimethyl-pyrazol-4-Methanamide (A.3.26), N-[2-(2,4 dichloro benzene base)-2-methoxyl group-1-Methylethyl]-3-(difluoromethyl)-1-methyl pyrazole-4- Methanamide (A.3.27)；
-other respiration inhibitors (such as coordination compound I, agent of uncoupling): difluoro woods (diflumetorim) (A.4.1), (5,8-difluoro quinazoline-4-base)-{ 2-[the fluoro-4-of 2-(4-trifluoromethyl pyridine-2-base epoxide) phenyl] ethyl } Amine (A.4.2)；Nitrophenyl derivative: binapacryl (binapacryl) (A.4.3), dinobuton (dinobuton) (A.4.4), dinocap (dinocap) (A.4.5), fluazinam (fluazinam) (A.4.6)； Ferimzone (ferimzone) (A.4.7)；Organo-metallic compound: triphenyltin salt, such as fentinacetate (fentin-acetate) (A.4.8), Fentin chloride (fentin chloride) (A.4.9) or fentin hydroxide (fentin hydroxide)(A.4.10)；ametoctradin(A.4.11)；And Silthiopham (silthiofam)(A.4.12)；
B) sterol biosynthesis inhibitor (SBI antifungal)
-C14 demethylase inhibitors (DMI antifungal): triazole type: penta ring azoles (azaconazole) (B.1.1), Bitertanol (bitertanol) (B.1.2), bromuconazole (bromuconazole) (B.1.3), cyproconazole (cyproconazole) (B.1.4),Ether azoles (difenoconazole) (B.1.5), olefin conversion (diniconazole) (B.1.6), olefin conversion M (diniconazole-M) (B.1.7), oxole bacterium (epoxiconazole) (B.1.8), RH-7592 (fenbuconazole) (B.1.9), Fluquinconazole (fluquinconazole) (B.1.10), bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-ylmethyl)silane (flusilazole) (B.1.11), Flutriafol (flutriafol) (B.1.12), hexaconazole (hexaconazole) (B.1.13), amide azoles (imibenconazole) (B.1.14), cycltebuconazole (ipconazole) (B.1.15), ring penta azoles bacterium (metconazole) (B.1.17), nitrile bacterium azoles (myclobutanil) (B.1.18), oxpoconazole (B.1.19), paclobutrazol (paclobutrazole) (B.1.20), Wu Junzuo (penconazole) (B.1.21), propiconazole (propiconazole) (B.1.22), prothioconazoles (prothioconazole) (B.1.23), simeconazoles (simeconazole) (B.1.24), Tebuconazole (tebuconazole) (B.1.25), fluorine ether azoles (tetraconazole) (B.1.26), triazolone (triadimefon) (B.1.27), triadimenol (triadimenol) (B.1.28), triticonazole (triticonazole) (B.1.29), uniconazole P (uniconazole)(B.1.30)、1-[rel-(2S；3R)-3-(2-chlorphenyl)-2-(2,4 difluorobenzene base) epoxy Ethyl group methyl]-5-thiocyano-1H-[1,2,4] triazole (B.1.31), 2-[rel-(2S；3R)-3-(2-chlorobenzene Base)-2-(2,4 difluorobenzene base) oxiranylmethyl radical]-2H-[1,2,4] triazole-3-mercaptan (B.1.32), 2-[the chloro-4-of 2-(4-chlorophenoxy) phenyl]-1-(1,2,4-triazol-1-yl) amyl-2-alcohol (B.1.33), 1-[4-(4- Chlorophenoxy)-2-(trifluoromethyl) phenyl]-1-cyclopropyl-2-(1,2,4-triazol-1-yl) ethanol (B.1.34), 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl) phenyl]-1-(1,2,4-triazol-1-yl) butyl-2-alcohol (B.1.35), 2-[the chloro-4-of 2-(4-chlorophenoxy) phenyl]-1-(1,2,4-triazol-1-yl) butyl-2-alcohol (B.1.36), 2-[4-(4- Chlorophenoxy)-2-(trifluoromethyl) phenyl]-3-methyl isophthalic acid-(1,2,4-triazol-1-yl) butyl-2-alcohol (B.1.37), 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl) phenyl]-1-(1,2,4-triazol-1-yl) propan-2-ol (B.1.38), 2-[the chloro-4-of 2-(4-chlorophenoxy) phenyl]-3-methyl isophthalic acid-(1,2,4-triazol-1-yl) butyl-2-alcohol (B.1.39), 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl) phenyl]-1-(1,2,4-triazol-1-yl) amyl-2-alcohol (B.1.40), 2-[4-(4-fluorophenoxy)-2-(trifluoromethyl) phenyl]-1-(1,2,4-triazol-1-yl) propan-2-ol (B.1.41)； Imidazoles: imazalil (imazalil) (B.1.42), pefurazoate (pefurazoate) (B.1.43), Prochloraz (prochloraz) (B.1.44), fluorine bacterium azoles (triflumizol) (B.1.45)；Miazines, pyridines and piperazine Piperazine class: fenarimol (fenarimol) (B.1.46), nuarimol (nuarimol) (B.1.47), pyridine Speckle oxime (pyrifenox) (B.1.48), triforine (triforine) (B.1.49), [3-(4-chloro-2-fluorobenzene Base)-5-(2,4 difluorobenzene base) is differentAzoles-4-base]-(3-pyridine radicals) methanol (B.1.50), 2-[2-chloro-4-(4- Chlorophenoxy) phenyl]-1-(1,2,4-triazol-1-yl) amyl-3-alkynes-2-alcohol (B.1.51)；
-Δ 14-reductase inhibitor: 4-dodecyl-2,6-thebaine (aldimorph) (B.2.1), Bacterium spirit (dodemorph) (B.2.2), dodemorfe acetas (dodemorph-acetate) (B.2.3), fourth Benzene morpholine (fenpropimorph) (B.2.4), tridemorph (tridemorph) (B.2.5), fenpropidin (fenpropidin) (B.2.6), pipron (piperalin) (B.2.7), spiral shellCyclopentadienyl amine (spiroxamine)(B.2.8)；
-chlC4 inhibitor: fenhexamid (fenhexamid) (B.3.1)；
C) nucleic acid synthetic inhibitor
-phenylamide or acyl amino acids antifungal: M 9834 (benalaxyl) (C.1.1), refining benzene Frost spirit (benalaxyl-M) (C.1.2), kiralaxyl (C.1.3), metalaxyl (metalaxyl) (C.1.4), Metalaxyl-M (metalaxyl-M) (mefenoxam, C.1.5), fenfuram (ofurace) (C.1.6),Frost spirit (oxadixyl) (C.1.7)；
-other: hydroxyisoxazole (hymexazole) (C.2.1), different thiophene bacterium ketone (octhilinone) (C.2.2), evil quinoline Acid (oxolinic acid) (C.2.3), sulphur phonetic bacterium spirit (bupirimate) (C.2.4), 5-flurocytosine (C.2.5), the fluoro-2-of 5-(p-methylphenyl methoxyl group) pyrimidine-4-amine (C.2.6), the fluoro-2-of 5-(4-fluorophenyl first Epoxide) pyrimidine-4-amine (C.2.7)；
D) cell division and cytoskeleton inhibitor
-Antitubulin, such as benzimidazole, thiophanate class (thiophanate): benomyl (benomyl) (D1.1), carbendazim (carbendazim) (D1.2), furidazol (fuberidazole) (D1.3), Apl-Luster (thiabendazole) (D1.4), thiophanate methyl (thiophanate-methyl)(D1.5)；The chloro-7-of triazolo pyrimidine class: 5-(4-methyl piperidine-1- Base)-6-(2,4,6-trifluorophenyl)-[1,2,4] triazol [1,5-a] pyrimidine (D1.6)；
-other cell division inhibitors: diethofencarb (diethofencarb) (D2.1), Guardian (ethaboxam) (D2.2), Pencycuron (pencycuron) (D2.3), fluopicolide (fluopicolide) (D2.4), zoxamide (zoxamide) (D2.5), metrafenone (metrafenone) (D2.6), pyriofenone (D2.7)；
E) amino acid and protein synthetic inhibitor
-methionine synthetic inhibitor (anilino-pyrimidine): ring the third pyrimidine (cyprodinil) (E.1.1), phonetic bacterium Amine (mepanipyrim) (E.1.2), pyrimethanil (pyrimethanil) (E.1.3)；
-protein synthesis inhibitor: blasticidin-S (blasticidin-S) (E.2.1), spring thunder element (kasugamycin) (E.2.2), hydration spring thunder element (kasugamycin Hydrochloride-hydrate) (E.2.3), midolthromycin (mildiomycin) (E.2.4), streptomycin (streptomycin) (E.2.5), oxytetracycline (oxytetracyclin) (E.2.6), Polyoxin (polyoxine) (E.2.7), jingganmycin (validamycin A) (E.2.8)；
F) signal transduction inhibitor
-MAP/ Histidine kinase inhibitor: fluorine bacterium peace (fluoroimid) (F.1.1), isopropyl is fixed (iprodione) (F.1.2), sterilization profit (procymidone) (F.1.3), vinclozolin (vinclozolin) (F.1.4), fenpiclonil (fenpiclonil) (F.1.5), fluorineBacterium (fludioxonil)(F.1.6)；
-G-protein inhibitor: quinoxyfen (quinoxyfen) (F.2.1)；
G) lipoid and film synthetic inhibitor
-phospholipid biosynthesis inhibitor: Hinosan (edifenphos) (G.1.1), iprobenfos (iprobenfos) (G.1.2), pyrazophos (pyrazophos) (G.1.3), Isoprothiolane (isoprothiolane)(G.1.4)；
-lipid peroxidized: botran (dicloran) (G.2.1), pentachloronitrobenzene (quintozene) (G.2.2), Tecnazene (tecnazene) (G.2.3), tolelofos-methyl (tolclofos-methyl) (G.2.4), connection Benzene (G.2.5), chloroneb (chloroneb) (G.2.6), kobam (etridiazole) (G.2.7)；
-phospholipid biosynthesis and cell wall deposition: dimethomorph (dimethomorph) (G.3.1), flumorph (flumorph) (G.3.2), mandipropamid (mandipropamid) (G.3.3), pyrimorph (pyrimorph) (G.3.4), benzene metsulfovax (benthiavalicarb) (G.3.5), iprovalicarb (iprovalicarb) (G.3.6), valifenalate (G.3.7) and N-(1-(1-(4-cyano-phenyl) second sulphonyl Base) butyl-2-yl) carbamic acid 4-fluorophenyl ester (G.3.8)；
-affect compound and the fatty acid of cell membrane permeability: hundred dimensions spirit (propamocarb) (G.4.1)；
-inhibitors of fatty acid amide hydrolase: oxathiapiprolin (G.5.1), methanesulfonic acid 2-{3-[2-(1-{ [3,5-bis-(difluoromethyl-1H-pyrazol-1-yl] acetyl group } piperidin-4-yl)-1,3-thiazole -4-base]-4,5-dihydro-1,2-Azoles-5-base } phenylester (G.5.2), methanesulfonic acid 2-{3-[2-(1-{ [3,5-bis- (difluoromethyl)-1H-pyrazol-1-yl] acetyl group } piperidin-4-yl)-1,3-thiazole-4-yl]-4,5-dihydro -1,2-Azoles-5-base }-3-chlorphenyl ester (G.5.3)；
H) there is the inhibitor of many sites effect
-inorganic active material: Bordeaux mixture (Bordeaux mixture) (H.1.1), Schweinfurt green (H.1.2), hydrogen Copper oxide (H.1.3), Cupravit (copper oxychloride) (H.1.4), basic copper sulfate (H.1.5), Sulfur (H.1.6)；
-sulfur generation-and dithiocarbamate: ferric dimethyldithiocarbamate (ferbam) (H.2.1), Mancozeb (mancozeb) (H.2.2), maneb (maneb) (H.2.3), metham-sodium (metam) (H.2.4), generation Gloomy (metiram) (H.2.5), propineb (propineb) (H.2.6), thiram (thiram) (H.2.7), zineb (zineb) (H.2.8), ziram (ziram) (H.2.9)；
-organochlorine compound (such as phthalimide class, sulfonyl amine, chloro nitrile): anilazine (anilazine) (H.3.1), Bravo (chlorothalonil) (H.3.2), difoltan (captafol) (H.3.3), captan (captan) (H.3.4), folpet (folpet) (H.3.5), antibacterial Spirit (dichlofluanid) (H.3.6), dichlorophen (dichlorophen) (H.3.7), Perchlorobenzene (H.3.8), Pentachorophenol (pentachlorphenole) (H.3.9) and salt thereof, Rabcide (phthalide) (H.3.10), Tolyfluanid (tolylfluanid) (H.3.11), N-(4-chloro-2-nitrobenzophenone)-N-ethyl-4-methylbenzene Sulfonamide (H.3.12)；
-guanidine and other: guanidine (H.4.1), dodine (H.4.2), dodine free alkali (H.4.3), Guanoctine (guazatine) (H.4.4), iminoctadine (guazatine-acetate) (H.4.5), biguanide spicy acid salt (iminoctadine) (H.4.6), iminoctadine triacetate (iminoctadine-triacetate) (H.4.7), double eight guanidinesalts (iminoctadine-tris (albesilate)) (H.4.8), Delan's (dithianon) (H.4.9), 2,6-bis- Methyl isophthalic acid H, 5H-[1,4] dithiadiene also [2,3-c:5,6-c'] connection pyrroles-1,3,5,7 (2H, 6H)-tetrone (H.4.10)；
I) Cell wall synthesis inhibitor
-glucosan synthetic inhibitor: jingganmycin (validamycin) (I.1.1), Polyoxin (polyoxin B)(I.1.2)；
-melanin genesis inhibitor: pyroquilon (pyroquilon) (I.2.1), tricyclazole (tricyclazole) (I.2.2), Carpropamide (carpropamid) (I.2.3), double chlorine zarilamid (dicyclomet) (I.2.4), cyanogen bacterium Amine (fenoxanil) (I.2.5)；
J) plant defense inducing agent
-thiadiazoles element (acibenzolar-S-methyl) (J.1.1), probenazole (probenazole) (J.1.2), different Metsulfovax (isotianil) (J.1.3), tiadinil (tiadinil) (J.1.4), Prohexadione calcium (prohexadione-calcium)(J.1.5)；Phosphonic acid ester: fosetyl (fosetyl) (J.1.6), second phosphorus Aluminum (fosetyl-aluminum) (J.1.7), phosphorous acid and salt (J.1.8) thereof, potassium bicarbonate or sodium (J.1.9)；
K) unknown role pattern
-bronopol (bronopol) (K.1.1), go out demodicid mite grasshopper (chinomethionat) (K.1.2), cyflufenamid (cyflufenamid) (K.1.3), cymoxanil (cymoxanil) (K.1.4), dazomet (dazomet) (K.1.5), Debacarb (debacarb) (K.1.6), diclomezine (diclomezine) (K.1.7), difenzoquat (difenzoquat) (K.1.8), difenzoquat methylsulfuric acid ester (difenzoquat-methylsulfate) (K.1.9), diphenylamines (K.1.10), amine benzene pyrrole bacterium ketone (fenpyrazamine) (K.1.11), fluorine biphenyl bacterium (flumetover) (K.1.12), flusulfamide (flusulfamide) (K.1.13), flutianil (K.1.14), methasulfocarb (methasulfocarb) (K.1.15), N-Serve (nitrapyrin) (K.1.16), isopropyl disappear (nitrothal-isopropyl)(K.1.18)、oxathiapiprolin(K.1.19)、 Tolprocarb (K.1.20), copper 8-hydroxyquinolinate (oxin-copper) (K.1.21), the third oxygen quinoline (proquinazid) (K.1.22), tebufloquin (K.1.23), tecloftalam (K.1.24), azoles bacterium piperazine (triazoxide) (K.1.25), 2-butoxy-6-iodo-3-propyl group .alpha.-5:6-benzopyran-4-ketone (K.1.26), 2-[3,5- Two (difluoromethyl)-1H-pyrazol-1-yl]-1-[4-(4-{5-[2-(acrylate-2-alkynes-1-base epoxide) phenyl]-4,5- Dihydro-1,2-Azoles-3-base }-1,3-thiazol-2-yl) piperidin-1-yl] ethyl ketone (K.1.27), 2-[3,5-bis-(two Methyl fluoride)-1H-pyrazol-1-yl]-1-[4-(4-{5-[the fluoro-6-of 2-(acrylate-2-alkynes-1-base epoxide) phenyl]-4,5- Dihydro-1,2-Azoles-3-base }-1,3-thiazol-2-yl) piperidin-1-yl] ethyl ketone (K.1.28), 2-[3,5-bis-(two Methyl fluoride)-1H-pyrazol-1-yl]-1-[4-(4-{5-[the chloro-6-of 2-(acrylate-2-alkynes-1-base epoxide) phenyl]-4,5- Dihydro-1,2-Azoles-3-base }-1,3-thiazol-2-yl) piperidin-1-yl] ethyl ketone (K.1.29), N-(cyclopropyl first Oxyimino group-(6-difluoro-methoxy-2,3-difluorophenyl) methyl)-2-phenyl-acetamides (K.1.30), N'-(4-(4-chloro-3-4-trifluoromethylphenopendant)-2,5-3,5-dimethylphenyl)-N-ethyl-N-methyl carbonamidine (K.1.31), N'-(4-(4-fluoro-3-4-trifluoromethylphenopendant)-2,5-3,5-dimethylphenyl)-N-ethyl-N-first Base carbonamidine (K.1.32), N'-(2-methyl-5-trifluoromethyl-4-(3-TMS propoxyl group) benzene Base)-N-ethyl-N-methyl carbonamidine (K.1.33), N'-(5-difluoromethyl-2-methyl-4-(3-trimethyl silicane Alkyl propoxyl group) phenyl)-N-ethyl-N-methyl carbonamidine (K.1.34), the 2-Methoxyacetic acid 6-tert-butyl group-8- [5-(4-aminomethyl phenyl)-2,3-dimethyl is different for fluoro-2,3-dimethyl quinoline-4-base ester (K.1.35), 3-Azoles Alkane-3-base] pyridine (K.1.36), [5-(4-chlorphenyl)-2,3-dimethyl is different for 3-Oxazolidine-3-base] pyridine (pyrisoxazole) (K.1.37), N-(6-methoxypyridine-3-base) cyclopropane carboxamide (K.1.38), The chloro-1-of 5-(4,6-dimethoxypyridin-2-base)-2-methyl isophthalic acid H-benzimidazole (K.1.39), 2-(4-chlorobenzene Base) [4-(3,4-Dimethoxyphenyl) is different for-N-Azoles-5-base]-2-acrylate-2-alkynyloxy group acetamide, (Z)-3- Amino-2-cyano group-3-Cinnamic Acid ethyl ester (K.1.40), picarbutrazox (K.1.41), N-[6-[[(Z)-[(1-methyl tetrazolium-5-base) phenylmethylene] amino] epoxide methyl]-2-pyridine radicals] ammonia Base amyl formate (K.1.42), 2-[2-[(7,8-bis-fluoro-2-methyl-3-quinolin base) epoxide]-6-fluoro-phenyl] Propan-2-ol (K.1.43), 2-[the fluoro-6-of 2-[(8-fluoro-2-methyl-3-quinolin base) epoxide] phenyl] propan-2-ol (K.1.44), 3-(5-fluoro-3,3,4,4-tetramethyl-3,4-dihydro-isoquinoline-1-base) quinoline (K.1.45), 3-(4,4-bis-fluoro-3,3-dimethyl-3,4-dihydro-isoquinoline-1-base) quinoline (K.1.46), 3-(4,4,5-trifluoro -3,3-dimethyl-3,4-dihydro-isoquinoline-1-base) quinoline (K.1.47), 9-fluoro-2,2-dimethyl-5-(3-quinoline Quinoline base)-3H-1,4-benzo oxygen azepine(K.1.48)；
L) biological pesticide
L1) there is antifungal, bactericidal, kill the virus and/or the microorganism agriculture of plant defense activator activity Medicine: white lead parasitism spore (Ampelomyces quisqualis), Aspergillus flavus (Aspergillus flavus), Aureobasidium pullulans (Aureobasidium pullulans), bacillus amyloliquefaciens (Bacillus Amyloliquefaciens), Mo Haiwei bacillus cereus (B.mojavensis), Bacillus pumilus (B. Pumilus), simple bacillus cereus (B.simplex), solonchak bacillus cereus (B.solisalsi), hay Bacillus cereus (B.subtilis), solution starch Bacillus subtilis var (B.subtilis var. Amyloliquefaciens), Fructus Canarii albi candida mycoderma (Candida oleophila), antagonism yeast (C. Saitoana), Tomato Caused by Clavibacter michiganensis subsp. michiganensis (Clavibacter michiganensis) (phage), shield Shell mould (Coniothyrium minitans), Cryphonectria parasitica (Cryphonectria Parasitica), cryptococcus albidus (Cryptococcus albidus), Dilophosphora Alopecuri, point fusarium (Fusarium oxysporum), Clonostachys rosea f. Catenulate (also referred to as chain spore glues broom bacterium (Gliocladium catenulatum)), Gliocladium roseum (Gliocladium roseum), the molten bacillus of antibiotic (Lysobacter antibioticus), produce mould molten Bacillus (L.enzymogenes), the strange yeast of drupe prunus mume (sieb.) sieb.et zucc. (Metschnikowia fructicola), Microdochium dimerum, small spherical shell spore (Microsphaeropsis ochracea), white Aerogenesis mould (Muscodor albus), Paenibacillus polymyxa (Paenibacillus polymyxa), one-tenth The general bacterium of group (Pantoea vagans), big photovoltaicing leather bacteria (Phlebiopsis gigantea), Rhodopseudomonas (Pseudomonas sp.)、Pseudomonas chloraphis、Pseudozyma flocculosa、 Pichia anomala (Pichia anomala), pythium oligandrum (Pythium oligandrum), Sphaerodes mycoparasitica, streptomyces griseoviridus (Streptomyces griseoviridis), profit Enlightening streptomycete (S.lydicus), Streptomyces violaceoniger (S.violaceusniger), Tarlaromyces flavus (Talaromyces flavus), Trichoderma asperellum (Trichoderma asperellum), Trichoderma atroviride (T. Atroviride), top spore Trichoderma spp. (T.fertile), this Trichoderma spp. of lid nurse (T.gamsii), T.harmatum, Trichoderma harzianum (T.harzianum)；Trichoderma harzianum (T.harzianum) and Trichoderma viride (T.viride) Mixture；Porous Trichoderma spp. (T.polysporum) and the mixing of Trichoderma harzianum (T.harzianum) Thing；Hook Trichoderma spp. (T.stromaticum), green trichoderma (T.virens) (also referred to as G virens (Gliocladium virens)), Trichoderma viride (T.viride), Typhula phacorrhiza, Austria De Man thin base lattice spore (Ulocladium oudemansii), verticillium dahliae (Verticillium Dahlia), little zucchini yellow mosaic virus (avirulent strains)；
L2) there is antifungal, bactericidal, kill the virus and/or the biochemistry of plant defense activator activity Pesticide: chitosan (hydrolyzate), Harpin albumen, laminarin (laminarin), Herring oil, natamycin, plumpox virus coat protein, potassium bicarbonate or sodium, Reynoutria Sachlinensis extract, salicylic acid, tea tree oil；
L3) there is parasite killing, mite killing, kill the microbial pesticide of spiral shell and/or eelworm-killing activity: radiation soil Bacillus (Agrobacterium radiobacter), bacillus cereus (Bacillus cereus), strong Bacillus cereus (B.firmus), bacillus thuringiensis (B.thuringiensis), Su Yun gold spore bar Bacterium Aizawa subspecies (B.thuringiensis ssp.aizawai), bacillus thuringiensis subsp israelensis (B.t.ssp.israelensis), bacillus thuringiensis galleria mellonella waxmoth subspecies (B.t.ssp.galleriae), Soviet Union Cloud gold bacillus cereus Kurstaki (B.t.ssp.kurstaki), bacillus thuringiensis intend walking First subspecies (B.t.ssp.tenebrionis), beauveria bassiana (Beauveria bassiana), Bu Shi are white Stiff bacterium (B.brongniartii), bulkholderia cepasea (Burkholderia sp.), Chromobacterium subtsugae, carpocapsa pomonella granulosis virus (Cydia pomonella Granulosis virus), pseudo-carpocapsa pomonella granulosis virus (Cryptophlebia leucotreta Granulovirus) (CrleGV), heliothis armigera nuclear polyhedrosis virus (Helicoverpa armigera Nucleopolyhedrovirus) (HearNPV), fumosorosea (Isaria fumosorosea), Heterorhabditis bacteriophora-NJ (Heterorhabditis bacteriophora), Lecanicillium Longisporum, L.muscarium (being once called as Verticillium lecanii (Verticillium lecanii)), gold Testudinis green muscardine fungus (Metarhizium anisopliae), Metarhizium anisopliae locust mutation (M. Anisopliae var.acridum), Nomuraea rileyi (Nomuraea rileyi), paecilomyces fumosoroseus (Paecilomyces fumosoroseus), paecilomyces lilacinus (P.lilacinus), Japanese beetle class Bacillus cereus (Paenibacillus popilliae), Pasteurella (Pasteuria sp.), intend this prick Watt pasteurellosis bacillus (P.nishizawae), puncture pasteurella (P.penetrans), P.ramose, P.reneformis, P.thornea, P.usgae, pseudomonas fluorescens (Pseudomonas Fluorescens), spodoptera nuclear polyhedrosis virus (Spodoptera littoralis Nucleopolyhedrovirus) (SpliNPV), Si Shi Little space (Steinernema Carpocapsae), Si Shi noctuid nematicide (S.feltiae), sawfly nematicide (S.kraussei)；
L4) there is parasite killing, mite killing, kill the biochemical pesticides of spiral shell, pheromone and/or eelworm-killing activity: L-carvone, citral, acetic acid (E, Z)-7,9-12 carbon diene-1-base ester, Ethyl formate, (E, Z)-2,4-decatrienoic acid ethyl ester (pear ester), (Z, Z, E)-7,11,13-16 carbon three olefine aldehydr, butanoic acid heptan Ester, isopropyl myristate, a thousand li acid Garden lavender ester, LINL-OX, 2-methyl-1-butene alcohol, Methyleugenol, methyl jasmonate, (E, Z)-2,13-18 carbon diene-1-alcohol, (E, Z)-2,13- 18 carbon diene-1-alcohol acetic esters, (E, Z)-3,13-18 carbon diene-1-alcohol, R-1-octene-3-alcohol, Coptotermes formosanus Shtrari. pheromone (pentatermanone), potassium silicate, Sorbitol caprylate, acetic acid (E, Z, Z)-3,8,11-14 carbon trialkenyl ester, acetic acid (Z, E)-9,12-14 carbon diene-1-base ester, Z-7- Tetradecene-2-ketone, acetic acid Z-9-tetradecene-1-base ester, Z-11-fulure, Z-11-ten Four carbene-1-alcohol, Acacia farnesiana Willd. (Acacia negra) extract, grapefruit seed and pulp extract, Chenopodium ambrosiodes extract, Catnip oil, Neem oil, Quillaia saponaria (Quillay) Extract, Flos Tagetis Erectae oil；
L5) there is plant stress reduction, plant growth regulator, plant growing promotion and/or output increased The microbial pesticide of activity: agalactia azospirillum (Azospirillum amazonense), azospirillum brasilense Spirillum (A.brasilense), raw fat azospirillum (A.lipoferum), Irakense (A. Irakense), high salt azospirillum (A.halopraeferens), Bradyrhizobium (Bradyrhizobium sp.), the most raw root nodule bacteria of Erichsen (B.elkanii), the slow raw root nodule bacteria (B. of Japan Japonicum), the most raw root nodule bacteria in Liaoning (B.liaoningense), late feathering fan bean root nodule bacteria (B. Lupini), acide eating Darfot bacteria (Delftia acidovorans), AMF (Glomus Intraradices), middle raw rhizobium (Mesorhizobium sp.), bacillus alvei (Paenibacillus alvei), more raw than Lay penicillium sp (Penicillium bilaiae), rhizobium leguminosarum Kidney bean Thing type (Rhizobium leguminosarum bv.phaseoli), rhizobium leguminosarum Herba Trifolii Pratentis biotype (R.l.bv.trifolii)、R.l.bv.viciae、R.tropici、Sinorhizobium meliloti；
L6) there is plant stress reduction, plant growth regulator and/or plant products and carry highly active biology Chemical pesticide: abscisic acid (abscisic acid), aluminium silicate (Kaolin), 3-decen-2-one, Radix Ononis hircinae Flavin, isoflavone element, hesperetin, high rape plain lactone (homobrassinlide), humic acid esters, Jasmonic or its salt or derivant, lysophosphatidyl ethanolamine, naringenin, polymeric polyhydroxy acid, Yellow tang (Ascophyllum nodosum (Norway Sargassum (Norwegian kelp), Brown algae)) extract With brown seaweed (Ecklonia maxima (Sargassum)) extract；
M) growth regulator
Abscisic acid (M.1.1), first alachlor (amidochlor), ancymidol (ancymidol), 6-benzylamino Purine, brassinosteroid (brassinolide), Amchem 70-25 (butralin), chlormequat (chlormequat), Chlormequat (chlormequat chloride), Lipotril (choline Chloride), cyclanilide (cyclanilide), daminozide (daminozide), dikegulac (dikegulac), dimethipin (dimethipin), 2,6-lutidines (2,6-dimethylpuridine), Ethephon (ethephon), flumetralim (flumetralin), flurprimidol (flurprimidol), reach grass fluorine (fluthiacet), forchlorfenuron (forchlorfenuron), gibberellin (gibberellic acid), inabenfide (inabenfide), indole-3-acetic acid, maleic hydrazide (maleic hydrazide), fluorine grass sulphur (mefluidide) strong element (mepiquat), chlorination, is helped to help strong element (mepiquat chloride), naphthalene second Acid, N-6-benzyladenine, paclobutrazol, tune naphthenic acid (prohexadione), Prohexadione calcium, jasmine Acid inductor (prohydrojasmon), match diazole element (thidiazuron), triapenthenol (triapenthenol), trithio tributyl phosphate, 2,3,5 triiodobenzoic acid, TrinexAN_SNacethyl And uniconazole P (trinexapac-ethyl)；
N) herbicide
-ethanamide: Acetochlor (acetochlor) (N.1.1), alachlor (alachlor), butachlor (butachlor), kecaoan (dimethachlor), P DimethenamidP (dimethenamid) (N.1.2), Flufenacet (flufenacet) (N.1.3), mefenacet (mefenacet) (N.1.4), isopropyl methoxalamine (metolachlor) (N.1.5), metazachlor (metazachlor) (N.1.6), R-7465 (napropamide), naproanilide (naproanilide), pethoxamid (pethoxamid), pretilachlor (pretilachlor), propachlor (propachlor), thiophene ether grass amine (thenylchlor)；
-amino acid derivativges: bilanafos (bilanafos), glyphosate (glyphosate) (N.2.1), grass Ammonium phosphine (glufosinate) (N.2.2), sulphosate (sulfosate) (N.2.3)；
-aryloxyphenoxypropionate class: clodinafop-propargyl (clodinafop) (N.3.1), cyhalofop-butyl (cyhalofop-butyl)、Azoles diclofop-methyl (fenoxaprop) (N.3.2), fluazifop (fluazifop) (N.3.3), haloxyfop (haloxyfop) (N.3.4), metamifop (metamifop), propaquizafop (propaquizafop), quizalofop-ethyl (quizalofop), Quizalotop-ethyl (four Tetrahydrofurfuryl ester) (quizalofop-P-tefuryl)；
-bipyridyliums: diquat (diquat), Aerial gramoxone cation (paraquat) (N.4.1)；
-(sulfur generation) carbamates: asulam (asulam), butylate (butylate), carbetamide (carbetamide), different phenmedipham (desmedipham), dimepiperate (dimepiperate), flutter grass Go out (eptam (EPTC), esprocarb (esprocarb), Hydram (molinate), orbencarb (orbencarb), phenmedipham (phenmedipham) (N.5.1), prosulfocarb (prosulfocarb), barnyard grass Grass fear (pyributicarb), benthiocarb (thiobencarb), tri-allate (triallate)；
-cyclohexyl diketone: fourth oxygen cyclic ketones (butroxydim), clethodim (clethodim) (N.6.1), cycloxydim (cycloxydim) (N.6.2), clefoxidim (profoxydim) (N.6.3), sethoxydim (sethoxydim) (N.6.4), quinone oximes grass (tepraloxydim) (N.6.5), tralkoxydim (tralkoxydim)；
-dinitroaniline: benfluralin (benfluralin), fourth fluchloralin (ethalfluralin), oryzalin (oryzalin), pendimethalin (pendimethalin) (N.7.1), prodiamine (prodiamine) (N.7.2), trefanocide (trifluralin) (N.7.3)；
-diphenylether: acifluorfen (acifluorfen) (N.8.1), aclonifen (aclonifen), bifenox (bifenox), chloroformate grass (diclofop), ethoxyfenethyl (ethoxyfen), Fomesafen (fomesafen), lactofen (lactofen), Oxyfluorfen (oxyfluorfen)；
-hydroxy benzonitrile class: Brominal (bomoxynil) (N.9.1), dichlobenil (dichlobenil), ioxynil (ioxynil)；
-imidazolone type: miaow grass ester (imazamethabenz), imazamox (imazamox) (N.10.1), Imazapic (imazapic) (N.10.2), Arsenal (imazapyr) (N.10.3), Scepter (imazaquin) (N.10.4), Imazethapyr (imazethapyr) (N.10.5)；
-phenoxy acetic acids: clomeprop (clomeprop), 2,4 dichloro benzene ethoxyacetic acid (2,4-D)) (N.11.1), 2,4-DB, 2,4-drip propanoic acid (dichlorprop), MCPA, 2 first 4 chloroethene thioesters (MCPA-thioethyl), MCPB, Vi par (mecoprop)；
-Pyrazine: pyrazon (chloridazon) (N.11.1), flufenpyrethyl (flufenpyr-ethyl), reach Grass fluorine, monometflurazone (norflurazon), reach grass only (pyridate)；
-pyridines: Dorema ammoniacum pyridine (aminopyralid), morpholine acid dichloride picoline (clopyralid) (N.12.1), pyrrole Benfluralin (diflufenican), dithiopyr (dithiopyr), fluorine grass is with (fluridone), fluroxypyr (fluroxypyr) (N.12.2), picloram (picloram) (N.12.3), fluorine pyrrole acyl grass amine (picolinafen) (N.12.4), thiophene halozydine (thiazopyr)；
-sulfonylurea: sulphur ammonia Huang grand (amidosulfuron), tetrazolium Huang grand (azimsulfuron), the phonetic Huang of benzyl Grand (bensulfuron) (N.13.1), chlorimuron (chlorimuron-ethyl) (N.13.2), chlorsulfuron (chlorsulfuron), cinosulfuron (cinosulfuron), ring third are yellow grand (cyclosulfamuron) (N.13.3), ethoxysulfuron (ethoxysulfuron), pyridine ethyl methyl (flazasulfuron), flucetosulfuron (flucetosulfuron), fluorine pyridine Huang grand (flupyrsulfuron), Amide sulphur grand (foramsulfuron), pyrrole chlorsulfuron (halosulfuron), pyridine miaow Huang are grand (imazosulfuron), iodine sulphur grand (iodosulfuron) (N.13.4), mesosulfuronmethyl (mesosulfuron) (N.13.5), piperazine pyrazosulfuron (metazosulfuron), metsulfuron-methyl (metsulfuron-methyl) (N.13.6), nicosulfuron (nicosulfuron) (N.13.7), ring the third oxygen Huang Long (oxasulfuron), Fluoropyrimidinesulfuron (primisulfuron), fluorine third yellow grand (prosulfuron), Pyrazosulfuron (pyrazosulfuron), rimsulfuron (rimsulfuron) (N.13.8), ethyl methyl (sulfometuron), lead ethyl xanthate Huang grand (sulfosulfuron), thiophene methyl (thifensulfuron), ether benzene Huang Long (triasulfuron), tribenuron-methyl (tribenuron), trifloxysulfuron (trifloxysulfuron), Triflusulfuronmethyl (triflusulfuron) (N.13.9), tritosulfuron (tritosulfuron), 1-((the chloro-6-of 2- Propyl imidazole also [1,2-b] pyridazine-3-base) sulfonyl)-3-(4,6-dimethoxypyridin-2-base) urea；
-triazines: ametryn (ametryn), atrazine (atrazine) (N.14.1), bladex (cyanazine), Penta Kusatsu (dimethametryn), ethiozin (ethiozin), six piperazines are same (hexazinon) (N.14.2), benzene piperazine grass (metamitron), metribuzin (metribuzin), prometryn (prometryn), Simanex (simazine), Garagard (terbuthylazine), terbutryn (terbutryn), phenoxy propylamine Tianjin (triaziflam；
-ureas: chlortoluron (chlorotoluron), Rhizoma et radix valerianae grand (daimuron), diuron (diuron) (N.15.1), fluometuron (fluometuron), isoproturon (isoproturon), Du Pont Herbicide 326 (linuron), methabenz thiazuron (methabenzthiazuron), Metribuzin (tebuthiuron)；
-other inhibitor of acetolactate synthetase: bispyribac-sodium (bispyribac-sodium), chlorine ester sulphur Grass amine (cloransulam-methyl), the phonetic sulfanilamide of azoles (diclosulam), florasulam (florasulam) (N.16.1), flucarbazonesodium (flucarbazone), fluorine ethofumesate (flumetsulam), Azoles grass sulfanilamide (metosulam), orthosulfamuron (ortho-sulfamuron), penoxsuam (penoxsulam), propoxyl group carbazones (propoxycarbazone), propyl-ester nitorfen (pyribambenz-propyl), phonetic benzene grass oxime (pyribenzoxim), pyriftalid (pyriftalid), Oxime pyridine grass (pyriminobac-methyl), pyrimisulfan, phonetic sulfur benzoic acid (pyrithiobac), Pyroxasulfone (N.16.2), pyroxsulam (pyroxsulam)；
-other: amicarbazone (amicarbazone), aminotriazole (aminotriazole), anilofos (anilofos), beflubutamid, benazolin (benazolin), bencarbazone, Benfluresate, benzofenap (benzofenap), bentazon (bentazone) (N.17.1), benzo are double Cyclic ketones (benzobicyclon), bicyclopyrone, bromacil (bromacil), bromobutide (bromobutide), butafenacil (butafenacil), cremart (butamifos), amine grass azoles (cafenstrole), fluorine ketazolam grass (carfentrazone), cinidon-ethyl (cinidon-ethyl) (N.17.2), chlorthal (chlorthal), cinmethylin (cinmethylin) (N.17.3), clomazone (clomazone) (N.17.4), cumyluron (cumyluron), cyprosulfamide, Mediben (dicamba) (N.17.5), difenzoquat, two Fluorine pyrrole grand (diflufenzopyr) (N.17.6), Drechslera monoceras (Drechslera monoceras), Dichlobenil (endothal), ethofumesate (ethofumesate), diphenyl (etobenzanid), Fenoxasulfone, fentrazamide (fentrazamide), Flumiclorac pentyl (flumiclorac-pentyl), fluorinePiperazine ketone (flumioxazin), amine grass azoles (flupoxam), fluorine are coughed up Oxadiazon (fluorochloridone), flurtamone (flurtamone), indanofan (indanofan), different evil Grass amine (isoxaben), differentFluorine grass (isoxaflutole), lenacil (lenacil), Stam F-34 (propanil), Pronamide (propyzamide), dichloro quinolinic acid (quinclorac) (N.17.7), quinmerac (quinmerac) (N.17.8), Mesotrione (mesotrione) (N.17.9), methylarsinic acid (methyl Arsonic acid), alanap (naptalam), propargylAzoles grass (oxadiargyl), Lonster (oxadiazon), chlorinePiperazine grass (oxaziclomefone), pentaAzoles grass (pentoxazone), oxazoline Grass ester (pinoxaden), pyraclonil (pyraclonil), pyraflufen-ethyl (pyraflufen-ethyl), Pyrasulfotole, pyrazoxyfen (pyrazoxyfen), pyrazolate (pyrazolynate), quinoclamine (quinoclamine), benzene flumetsulam (saflufenacil) (N.17.10), sulphur oxadiazon (sulcotrione) (N.17.11), sulfentrazone (sulfentrazone), terbacil (terbacil), tefuryltrione、tembotrione、thiencarbazone、topramezone(N.17.12)、(3-[2- The fluoro-5-of chloro-4-(3-methyl-2,6-dioxo-4-trifluoromethyl-3,6-dihydro-2H-pyrimidine-1-base) phenoxy group] Pyridine-2-base epoxide) ethyl acetate, 6-amino-5-chloro-2-cyclopropyl-pyrimidine-4-methyl formate, 6-chlorine -3-(2-cyclopropyl-6-methylphenoxy) pyridazine-4-alcohol, the chloro-6-of 4-amino-3-(4-chlorphenyl)-5-fluorine pyrrole Pyridine-2-formic acid, the chloro-6-of 4-amino-3-(the chloro-2-of 4-fluoro-3-methoxyphenyl) pyridine-2-methyl formate and The chloro-6-of 4-amino-3-(4-chloro-3-dimethylamino-2-fluorophenyl) pyridine-2-methyl formate；
O) insecticide
-organic (sulfur generation) phosphate ester: accephate (acephate) (O.1.1), azoles pyridine phosphorus (azamethiphos) (O.1.2), Bayer 17147 (azinphos-methyl) (O.1.3), chlopyrifos (chlorpyrifos) (O.1.4), chlorpyrifos-methyl (chlorpyrifos-methyl) (O.1.5), chlorfenviphos (chlorfenvinphos) (O.1.6), basudin (diazinon) (O.1.7), dichlorvos (dichlorvos) (O.1.8), Carbicron (dicrotophos) (O.1.9), Rogor (dimethoate) (O.1.10), disulfoton (disulfoton) (O.1.11), Ethodan (ethion) (O.1.12), Folithion (fenitrothion) (O.1.13), fenthion (fenthion) (O.1.14), differentAzoles phosphorus (isoxathion) (O.1.15), Malathion (malathion) (O.1.16), Bayer 71628 (methamidophos) (O.1.17), methidathion (methidathion) (O.1.18), parathion-methyl (methyl-parathion) (O.1.19), Menite (mevinphos) (O.1.20), Azodrin (monocrotophos) (O.1.21), metilomerkaptofosoksid (oxydemeton-methyl) (O.1.22), paraoxon (paraoxon) (O.1.23), 1 (parathion) (O.1.24), phenthoate dimephenthoate cidial (phenthoate) (O.1.25), Phosalone (phosalone) (O.1.26), phosmet (phosmet) (O.1.27), phosphamidon (phosphamidon) (O.1.28), thimet (phorate) (O.1.29), phoxim (phoxim) (O.1.30), pirimiphosmethyl (pirimiphos-methyl) (O.1.31), Profenofos (profenofos) (O.1.32), BAY-NTN 8629 (prothiofos) (O.1.33), demephion (sulprophos) (O.1.34), tetrachlorvinphos (tetrachlorvinphos) (O.1.35), Terbufos (terbufos) (O.1.36), triazophos (triazophos) (O.1.37), metrifonate (trichlorfon)(O.1.38)；
-carbamates: alanycarb (alanycarb) (O.2.1), Aldicarb (aldicarb) (O.2.2), Worm prestige (bendiocarb) (O.2.3), Benfuracard micro (benfuracarb) (O.2.4), carbaryl (carbaryl) (O.2.5), furadan (carbofuran) (O.2.6), carbosulfan (carbosulfan) (O.2.7), ABG-6215 (fenoxycarb) (O.2.8), furathiocarb (furathiocarb) (O.2.9), mercaptodimethur (methiocarb) (O.2.10), methomyl (methomyl) (O.2.11), methomyl (oxamyl) (O.2.12), Aphox (pirimicarb) (O.2.13), arprocarb (propoxur) (O.2.14), thiodicarb (thiodicarb) (O.2.15), triaguron (triazamate) (O.2.16)；
-pyrethroids: Pynamin (allethrin) (O.3.1), bifenthrin (bifenthrin) (O.3.2), cyfloxylate (cyfluthrin) (O.3.3), (RS) lambda-cyhalothrin (cyhalothrin) (O.3.4), cyphenothrin (cyphenothrin) (O.3.5), cypermethrin (cypermethrin) (O.3.6), alpha cypermethrin (alpha-cypermethrin) (O.3.7), second Body cypermethrin (beta-cypermethrin) (O.3.8), own body cypermethrin (zeta-cypermethrin) (O.3.9), decis (deltamethrin) (O.3.10), high cyanogen penta chrysanthemum Ester (esfenvalerate) (O.3.11), ethofenprox (etofenprox) (O.3.11), Fenpropathrin (fenpropathrin) chrysanthemum ester (fenvalerate) (O.3.13), miaow alkynes chrysanthemum ester (O.3.12), are killed (imiprothrin) (O.3.14), lambda-cyhalothrin (lambda-cyhalothrin) (O.3.15), chlorine chrysanthemum Ester (permethrin) (O.3.16), prallethrin (prallethrin) (O.3.17), pyrethrin (pyrethrin) I and II (O.3.18), Chryson (resmethrin) (O.3.19), deinsectization silicon ether (silafluofen) (O.3.20), taufluvalinate (tau-fluvalinate) (O.3.21), Tefluthrin (tefluthrin) (O.3.22), tetramethrin (tetramethrin) (O.3.23), tralomethrin (tralomethrin) (O.3.24), transfluthrin (transfluthrin) (O.3.25), the third Flumethrin (profluthrin) (O.3.26), dimefluthrin (dimefluthrin) (O.3.27)；
-insect growth regulator, IGR: a) chitin synthesis inhibitor: benzoyl area kind: UC 62644 (chlorfluazuron) (O.4.1), cyromazine (cyramazin) (O.4.2), TH-6040 (diflubenzuron) (O.4.3), flucycloxuron (flucycloxuron) (O.4.4), Cascade (flufenoxuron) (O.4.5), HEXAFLUMURON (hexaflumuron) (O.4.6), fluorine the third oxygen urea (lufenuron) (O.4.7), Novaluron (novaluron) (O.4.8), Teflubenzuron (teflubenzuron) (O.4.9), parasite killing grand (triflumuron) (O.4.10)；Buprofezin (buprofezin)(O.4.11)、Cyclopentadienyl ether (diofenolan) (O.4.12), Hexythiazox (hexythiazox) (O.4.13), special benzeneAzoles (etoxazole) (O.4.14), clofentezine (clofentazine)(O.4.15)；B) ecdyson antagonist: Benzoic acid N-tert-butyl-N-(4-chlorobenzoyl)hydrazide (halofenozide) (O.4.16), Runner (methoxyfenozide) (O.4.17), double benzoyl Hydrazine (tebufenozide) (O.4.18), Ai Zhading (azadirachtin) (O.4.19)；C) juvenile hormone class Like thing: pyriproxyfen (pyriproxyfen) (O.4.20), Entocon ZR 515 (methoprene) (O.4.21), ABG-6215 (O.4.22)；D) Lipid biosynthesis inhibitors: Envidor (spirodiclofen) (O.4.23), Spiromesifen (spiromesifen) (O.4.24), spiral shell worm ethyl ester (spirotetramat) (O.4.24)；
-nicotinic receptor agonists/agonist compounds: clothianidin (clothianidin) (O.5.1), MTI-446 (dinotefuran) (O.5.2), flupyradifurone (O.5.3), imidacloprid (imidacloprid) (O.5.4), Diacloden (thiamethoxam) (O.5.5), nitenpyram (nitenpyram) (O.5.6), acetamiprid (acetamiprid) (O.5.7), thiacloprid (thiacloprid) (O.5.8), the chloro-thiazole of 1-2--5-ylmethyl)-2-nitryl imino group (nitrimino)-3,5-dimethyl-[1,3,5] triazine alkane (triazinane) (O.5.9)；
-GABA agonist compounds: 5a,6,9,9a-hexahydro-6,9-methano-2,4 (endosulfan) (O.6.19), ethiprole (ethiprole) (O.6.2), Frontline (fipronil) (O.6.3), fluorine pyrazoles worm (vaniliprole) (O.6.4), Pyrafluprole (O.6.5), pyriprole (O.6.6), 5-amino-1-(2,6-bis-chloro-4-aminomethyl phenyl)-4- Sulfenyl aminoacyl (sulfinamoyl)-1H-pyrazoles-3-thioformamide (O.6.7)；
-macrolide insecticide: Olivomitecidin (abamectin) (O.7.1), Affirm (Merck Co.) (emamectin) (O.7.2), milbemycin (milbemectin) (O.7.3), lepimectin (O.7.4), Spinosad (spinosad) (O.7.5), ethyl pleocidin (spinetoram) (O.7.6)；
-Mitochondrial electron transport inhibitors (METI) I acaricide: fenazaquin (fenazaquin) (O.8.1), Pyridaben (pyridaben) (O.8.2), tebufenpyrad (tebufenpyrad) (O.8.3), Tolfenpyrad (tolfenpyrad) (O.8.4), phonetic worm amine (flufenerim) (O.8.5)；
-METI II and III compound: acequinocyl (acequinocyl) (O.9.1), fluacyprim (O.9.2), Amdro (hydramethylnon) (O.9.3)；
-agent of uncoupling: chlorfenapyr (chlorfenapyr) (O.10.1)；
-oxidative phosphorylation inhibitors: plictran (cyhexatin) (O.11.1), mite killing sulfur are grand (diafenthiuron) (O.11.2), fenbutatin oxide (fenbutatin oxide) (O.11.3), propargite (propargite)(O.11.4)；
-agent interfering compound of casting off a skin: cyromazine (cryomazine) (O.12.1)；
-mixed-function oxidase inhibitor: Butacide (piperonyl butoxide) (O.13.1)；
-sodium channel blockers:Diazole worm (indoxacarb) (O.14.1), metaflumizone (metaflumizone)(O.14.2)；
-Ryanicide (ryanodine) acceptor inhibitor: chlorantraniliprole (chlorantraniliprole) (O.15.1), Cyanogen insect amide (cyantraniliprole) (O.15.2), Flubendiamide (flubendiamide) (O.15.3), N-[the chloro-2-of 4,6-bis-[(diethyl-λ-4-sulfurous base (sulfanylidene)) carbamoyl] benzene Base]-2-(3-chloro-2-pyridyl)-5-(trifluoromethyl) pyrazole-3-formamide) (O.15.4), N-[4-chlorine -2-[(diethyl-λ-4-sulfurous base) carbamoyl]-6-aminomethyl phenyl]-2-(3-Chloro-2-Pyridyle Base)-5-(trifluoromethyl) pyrazole-3-formamide) (O.15.5), N-[the chloro-2-of 4-[(two-2-propyl group-λ-4-sulfurous Base) carbamoyl]-6-aminomethyl phenyl]-2-(3-chloro-2-pyridyl)-5-(trifluoromethyl) pyrazoles-3-formyl Amine) (O.15.6), N-[the chloro-2-of 4,6-bis-[(two-2-propyl group-λ-4-sulfurous bases) carbamoyl]-benzene Base]-2-(3-chloro-2-pyridyl)-5-(trifluoromethyl) pyrazole-3-formamide) (O.15.7), N-[4,6-dichloro -2-[(diethyl-λ-4-sulfurous base) carbamoyl]-phenyl]-2-(3-chloro-2-pyridyl)-5-(difluoro first Base) pyrazole-3-formamide) (O.15.8), N-[the bromo-2-of 4,6-bis-[(two-2-propyl group-λ-4-sulfurous bases) amino Formoxyl]-phenyl]-2-(3-chloro-2-pyridyl)-5-(trifluoromethyl) pyrazole-3-formamide) (O.15.9), N-[the chloro-2-of 4-[(two-2-propyl group-λ-4-sulfurous bases) carbamoyl]-6-cvano-phenyl]-2-(the chloro-2-of 3- Pyridine radicals)-5-(trifluoromethyl) pyrazole-3-formamide) (O.15.10), N-[4,6-bis-bromo-2-[(diethyl -λ-4-sulfurous base) carbamoyl]-phenyl]-2-(3-chloro-2-pyridyl)-5-(trifluoromethyl) pyrazoles-3- Methanamide) (O.15.11)；
-other: benclothiaz (O.16.1), Bifenazate (bifenazate) (O.16.2), cartap (cartap) (O.16.3), flonicamid (flonicamid) (O.16.4), pyridalyl (pyridalyl) (O.16.5), pymetrozine (pymetrozine) (O.16.6), sulfur (O.16.7), thiocyclarn (thiocyclam) (O.16.8), cyenopyrafen (O.16.9), Flupyrazofos-containpesticide (flupyrazofos) (O.16.10), cyflumetofen (cyflumetofen) (O.16.11), Amidoflumet (O.16.12), imicyafos (O.16.13), bistrifluron (bistrifluron) (O.16.14), pyrifluquinazon (O.16.15) and 1,1'-[(3S, 4R, 4aR, 6S, 6aS, 12R, 12aS, 12bS)-4-[[(2-Cyclopropyl-acetyl) epoxide] first Base]-1,3,4,4a, 5,6,6a, 12,12a, 12b-decahydro-12-hydroxyl-4,6a, 12b-trimethyl-11-oxo -9-(3-pyridine radicals)-2H, 11H-naphtho-[2,1-b] pyrans also [3,4-e] pyrans-3,6-diyl] cyclopropane second Acid esters (O.16.16).
Additionally, the present invention relates to comprise at least one compound I (component 1) and at least one is selected from Above-mentioned A)-O) group, other antifungal especially a kind of, such as one or more are selected from A)-K) organize The mixture of other active substances (component 2) that can be used for plant protection of antifungal and needs Talk about a kind of suitable solvent or the agrochemical composition of solid carrier.These mixture make us sense especially Interest, because many of which demonstrates more efficient power under identical rate of application to harmful fungoid.This Outward, with inclusion compound I and at least one selected from above-mentioned A)-K) mixture of antifungal organized prevents Control harmful fungoid than with single compound I or be selected from A)-K) the independent antifungal organized prevents and treats those Fungus is more effective.
By by compound I with at least one selected from A)-O) use together with the active substance organized, permissible Obtain cooperative synergism effect, the effect i.e. obtained simply adding and (Synergistic mixing more than independent effect Thing).
This can i.e. combine (such as tank mix) or separate by simultaneously, or using chemical combination successively Thing I and at least one other active substance and obtain, wherein select the time interval between using each time To guarantee that the active substance of initial application is still present in effect with q.s when using other active substances Position.Order of administration is unimportant to the enforcement of the present invention.
As administered compound I and pesticide II successively, the time between administered twice can be such as 2 Hour change between 7 days.0.25 hour to 30 days, preferably 0.5 hour to 14 days, particularly 1 Hour to 7 days or 1.5 hours to 5 days, the wider range of even more preferably 2 hours to 1 day is also Possible.Comprising selected from L) in the case of the mixture of pesticide II organized, preferably this pesticide II conduct Finally process and use.
According to the present invention, consolidating of biological pesticide (except the oil of such as Neem oil, Flos Tagetis Erectae oil etc.) Body material (dry) is considered as that active component (is such as being dried or is evaporating Extraction medium or in microorganism Obtain after suspension media in the case of the liquid adjustments of pesticide).
According to the present invention, herein for weight ratio and the percentage base of bio-extract such as Quillaia saponaria extract Gross weight in the dry content (solid material) of corresponding extract.
Comprise at least one microbial pesticide including dormancy form in the microbial cell form lived Compositions gross weight than can use corresponding microorganism CFU amount calculate corresponding active component Gross weight and determine, use following equalities: 1 × 109CFU is equal to 1 gram of corresponding active component gross weight Amount.Colony-forming units is the microbial cell lived, especially fungus and the tolerance of bacterial cell.This Outward, " CFU " is at (entomopathogenicity) nematicide biological pesticide here, such as brassica rapa nematicide (Steinernema Feltiae) it is also understood that the number into single nematicide (larva) in the case of.
In the binary mixture and compositions of the present invention, component 1) and component 2) weight ratio generally take Certainly in the performance of active substance used, usually 1:100-100:1, usually from 1:50-50:1, preferably 1:20-20:1, more preferably 1:10-10:1, even more preferably 1:4-4:1, especially 1:2-2:1.
According to other embodiments of binary mixture and compositions, component 1) and component 2) weight ratio Usually 1000:1-1:1, usually from 100:1-1:1, often 50:1-1:1, preferably 20:1-1:1, More preferably 10:1-1:1, even more preferably 4:1-1:1, especially 2:1-1:1.
According to other embodiments of binary mixture and compositions, component 1) and component 2) weight ratio Usually 1:1-1:1000, usually from 1:1-1:100, often 1:1-1:50, preferably 1:1-1:20, more Preferably 1:1-1:10, even more preferably 1:1-1:4, especially 1:1-1:2.
At ternary mixture, i.e. comprise component 1), component 2) and the present invention of compound III (component 3) In compositions, component 1) and component 2) weight ratio depend on the performance of active substance used, it is usual For 1:100-100:1, usually from 1:50-50:1, preferably 1:20-20:1, more preferably 1:10-10:1, especially It is 1:4-4:1, and component 1) and component 3) weight ratio be usually 1:100-100:1, usually from 1:50-50:1, preferably 1:20-20:1, more preferably 1:10-10:1, especially 1:4-4:1.
If necessary, any other active component adds component 1 with the ratio of 20:1-1:20) in.
These ratios also are adapted for the inventive mixture used by seed treatment.
Further preferably comprise at least one selected from A) group, be especially selected from (A.1.1), (A.1.4), (A.1.8), (A.1.9)、(A.1.12)、(A.1.13)、(A.1.14)、(A.1.17)、(A.1.19)、(A.1.21)、(A.2.1)、 (A.2.2)、(A.3.2)、(A.3.3)、(A.3.4)、(A.3.7)、(A.3.8)、(A.3.9)、(A.3.12)、(A.3.14)、 (A.3.15)、(A.3.16)、(A.3.19)、(A.3.20)、(A.3.21)、(A.3.22)、(A.3.23)、(A.3.24)、 (A.3.25)、(A.3.26)、(A.3.27)；(A.4.5), (A.4.6), (A.4.8), (A.4.9) and (A.4.11) Active substance as component 2) mixture.
Preferably containing at least a kind of selected from B) group, it is especially selected from (B.1.4), (B.1.5), olefin conversion (B.1.6)、(B.1.8)、(B.1.10)、(B.1.11)、(B.1.12)、(B.1.17)、(B.1.18)、(B.1.21)、 (B.1.22)、(B.1.23)、(B.1.25)、(B.1.26)、(B.1.27)、(B.1.28)、(B.1.29)、uni(B.1.31)、 (B.1.32)、(B.1.33)、(B.1.34)、(B.1.35)、(B.1.36)、(B.1.37)、(B.1.38)、(B.1.39)、 (B.1.40), (B.1.41), (B.1.42), (B.1.44), (B.1.46), (B.1.49) and (B.1.50)；(B.2.2)、 (B.2.4), (B.2.5), (B.2.6), the active substance of pipron (B.2.7), (B.2.8) and (B.3.1) are made For component 2) mixture.
Preferably containing at least a kind of selected from C) group, be especially selected from (C.1.4), C.1.5), (C.1.6) and (C.2.4) active substance is as component 2) mixture.
Preferably containing at least a kind of selected from D) group, be especially selected from (D1.1), (D1.2), (D1.4), (D1.5), the active substance of (D2.2), (D2.4), (D2.5), (D2.6) and (D2.7) is as component 2) Mixture.
Further preferably comprise at least one selected from E) group, it is especially selected from (E.1.1), (E.1.2) and (E.1.3) Active substance as component 2) mixture.
Further preferably comprise at least one selected from F) group, be especially selected from (F.1.2), (F.1.4), (F.1.5), (F.1.6) and the active substance of (F.2.1) is as component 2) mixture.
Further preferably comprise at least one selected from G) group, be especially selected from (G.3.1), (G.3.2), (G.3.3), (G.3.4), (G.3.5), the active substance of (G.3.6), (G.4.1) and (G.5.1) is as component 2) mixing Thing.
Further preferably comprise at least one selected from H) group, its for and be especially selected from (H.1.2), (H.1.3), Cupravit (H.1.4), (H.1.5), (H.1.6)；(H.2.2)、(H.2.5)、(H.2.7)、(H.3.2)、(H.3.3)、 (H.3.4), (H.3.5), (H.3.6), (H.3.12), (H.4.2), (H.4.6), Delan's (H.4.9) and (H.4.10) Active substance as component 2) mixture.
Further preferably comprise at least one selected from I) group, it is especially selected from (I.2.3) and the active substance of (I.2.5) As component 2) mixture.
Further preferably comprise at least one selected from J) group, be especially selected from (J.1.1), (J.1.2), (J.1.3), (J.1.4), (J.1.6), the active substance of (J.1.7), (J.1.8) and (J.1.9) is as component 2) mixture.
Further preferably comprise at least one selected from K) group, be especially selected from (K.1.4), (K.1.5), (K.1.8), (K.1.12), (K.1.14), the active substance of (K.1.15), (K.1.19) and (K.1.22) is as component 2) Mixture.
Selected from L) group pesticide II biological pesticide, its preparation and such as to harmful fungoid or the agriculture of insecticide Medicine activity is known (e-Pesticide Manual V 5.2 (ISBN 978 1 901,396 85 0)(2008-2011)；Http:// www.epa.gov/opp00001/biopesticides/, is shown in product therein Enumerate；Http:// www.omri.org/omri-lists, is shown in therein enumerating；Bio-Pesticides Database BPDB http://sitem.herts.ac.uk/aeru/bpdb/, is shown in that A-Z therein links).
Selected from L1) and/or L2) biological pesticide organized can also have parasite killing, mite killing, kill spiral shell, information The reduction of element, nematicide, plant stress, plant growth regulator, plant growing promotion and/or yield carry High activity.Selected from L3) and/or L4) biological pesticide organized can have antifungal, bactericidal, kill disease Poison, plant defense activator, plant stress reduction, plant growth regulator, plant growing promote and/ Or output increased activity.Selected from L5) and/or L6) biological pesticide organized can also have antifungal, kill Antibacterial, kill the virus, plant defense activator, parasite killing, mite killing, kill spiral shell, pheromone and/or nematicide Activity.
These biological pesticides many are registered and/or commercially available: aluminium silicate (ScreenTMDuo, from Certis LLC, USA), agrobacterium radiobacter K1026 is (such asFrom BASF Agricultural Specialties Pty Ltd, Australia), agrobacterium radiobacter (A. Radiobacter) K84 (Nature 280,697-699,1979；Such asFrom AG Biochem, Inc., C, USA), white lead parasitism spore M-10 is (such asFrom Intrachem Bio GmbH&Co.KG, Germany), yellow tang (Norway Sargassum, Brown algae) extract or filtrate are (such as ORKA GOLD, from South Africa BASF Agricultural Specialities (Pty) Ltd.；OrFrom Laboratoires Goemar, France), 1991 at Georgia by USDA, The Aspergillus flavus NRRL that National Peanut Research Laboratory separates from Semen arachidis hypogaeae 21882 (such asFrom Syngenta, CH), Aureobasidium pullulans DSM 14940 With the mixture of DSM 14941 (such as blastopore,From bio-ferm GmbH, Germany), agalactia azospirillum BR 11140 (SpY2T)(Proc.9th Int.and 1st Latin American PGPR meeting, Quimara, Medell í n, Colombia 2012, page 60, ISBN 978-958-46-0908-3), Azospirillum brasilense AZ39 (Eur.J.Soil Biol 45 (1), 28-35,2009), Azospirillum brasilense XOH (such as AZOS, from Xtreme Gardening, USA or RTI Reforestation Technologies International；USA), azospirillum brasilense spiral shell Bacterium BR 11002 (Proc.9th Int.and 1stLatin American PGPR meeting, Quimara, Medell í n, Colombia 2012, the 60th page, ISBN 978-958-46-0908-3), Azospirillum brasilense BR 11005 (SP245；Such as GELFIX Gram í neas, from BASF Agricultural Specialties Ltd., Brazil), raw fat azospirillum BR 11646 (Sp31) (Proc. 9th Int.and 1stLatin American PGPR meeting, Quimara, Medell í n, Colombia 2012, page 60), bacillus amyloliquefaciens FZB42 is (such as42, From AbiTEP GmbH, Berlin, Germany), bacillus amyloliquefaciens IN937a (J.Microbiol. Biotechnol.17 (2), 280-286,2007；Such asFrom Gustafson LLC, TX, USA), bacillus amyloliquefaciens IT-45 (CNCM I-3800) (such as Rhizocell C, from France ITHEC), bacillus amyloliquefaciens plant subspecies (B.amyloliquefaciens ssp. Plantarum) MBI600 (NRRL B-50595, be preserved in USDA) is (such as NG, from BASF Corp., USA), bacillus cereus CNCM I-1562 (US 6,406,690), bacillus firmus CNCM I-1582 (WO 2009/126473, WO 2009/124707, US 6,406,690；From Bayer Crop Science LP, USA), Bacillus pumilus GB34 (ATCC 700814；Such asFrom Gustafson LLC, TX, USA), Bacillus pumilus KFP9F (NRRL B-50754) is (such as BAC-UP or FUSION-P, from South Africa BASF Agricultural Specialities (Pty) Ltd.), Bacillus pumilus QST 2808 (NRRL B-30087) is (such asWith Plus, from AgraQuest Inc., USA), bacillus subtilis GB03 is (such asOrFrom Gustafson, Inc., USA；OrFrom Growth Products, Ltd., White Plains, NY 10603, USA), bacillus subtilis GB07(From Gustafson, Inc., USA), bacillus subtilis QST-713 (NRRL B-21661,MAX andASO, from AgraQuest Inc., USA), solve starch Bacillus subtilis var FZB24 (such as From Novozyme Biologicals, Inc., USA), solve starch Bacillus subtilis var D747 (example Such as Double Nickel 55, from Certis LLC, USA), bacillus thuringiensis ABTS-1857 is (such asFrom BioFa AG, M ü nsingen, Germany), Su Yunjin Bacillus cereus Aizawa subspecies SAN 401I, ABG-6305 and ABG-6346, bacillus thuringiensis Israel subclass AM65-52 is (such asFrom Valent BioSciences, IL, USA), Bacillus thuringiensis Kurstaki SB4 (NRRL B-50753；Such as BetaCome From South Africa BASF Agricultural Specialities (Pty) Ltd.), it is equal to the Su Yunjin of HD-1 Bacillus cereus Kurstaki ABTS-351 (ATCC SD-1275；Such asDF, from Valent BioSciences, IL, USA), bacillus thuringiensis Kurstaki EG 2348 (example AsOrFrom Italy CBC (Europe) S.r.l.), Su Yun gold spore bar Bacterium intends walking first subspecies DSM 2803 (EP 0 585 215B1；It is equal to NRRL B-15939； Mycogen Corp.), bacillus thuringiensis intends walking first subspecies N B-125 (DSM 5526；EP 0 585 215B1；Also referred to as SAN 418I or ABG-6479；Produced for Novo-Nordisk in the past Bacterial strain), bacillus thuringiensis intends walking first subspecies N B-176 (or NB-176-1；Bacterial strain NB-125 Gamma-radiation induction High yield Mutant；DSM 5480；EP 585 215B1；Come From Switzerland Valent BioSciences), beauveria bassiana ATCC 74040 is (such as From Italy CBC (Europe) S.r.l.), beauveria bassiana DSM 12256 (US 200020031495；Such asSC, from Colombia Live Sytems Technology S.A.), beauveria bassiana GHA (22WGP, from Laverlam Int.Corp., USA), beauveria bassiana PPRI 5339 is (at entomopathogenicity fungal cultures In USDA ARS preservation No. ARSEF is 5339；NRRL 50757) (such as From South Africa BASF Agricultural Specialities (Pty) Ltd.), muscardine is (such asFrom Agrifutur, Agrianello, Italy, it is used for preventing and treating chafer；J.Appl. Microbiol.100 (5), 1063-72,2006), Bradyrhizobium is (such asFrom BASF Corp., USA), the slow raw root nodule bacteria of Japan are (such asFrom BASF Corp., USA), Fructus Canarii albi candida mycoderma I-182 (NRRL Y-18846；Such asFrom Ecogen Inc., USA, Phytoparasitica 23 (3), 231-234,1995), Fructus Canarii albi candida bacterial strain O (NRRL Y-2317；Biological Control 51,403-408,2009), antagonism yeast is (such as(in Mixture with lysozyme) andFrom Micro Flo Company, USA (BASF SE) And Arysta), chitosan is (such asFrom BotriZen Ltd., NZ), Clonostachys rosea f.catenulata, also referred to as chain spore glue broom bacterium (such as separator J 1446:From Finland Verdera Oy), in the middle part of Maryland, Catoctin mountain area is from Chinese hemlock spruce The Chromobacterium subtsugae that soil under (Tsuga canadensis) separates PRAA4-1 (such as GRANDEVO, from Marrone Bio Innovations, USA), shield The mould CON/M/91-08 of shell is (such asWG, from Germany Prophyta), parasitic hidden clump Red shell bacterium (such as product E ndothia parasitica, from France CNICM), cryptococcus albidus (example AsFrom South Africa Anchor Bio-Technologies), pseudo-carpocapsa pononella granule Precursor virus (CrleGV) (such as CRYPTEX, from Switzerland Adermatt Biocontrol), Fructus Mali pumilae Moth-eaten moth PuGV (CpGV) V03 (DSM GV-0006；Such as MADEX Max, from auspicious Scholar Andermatt Biocontrol), CpGV V22 (DSM GV-0014；Such as MADEX Twin, from Switzerland Adermatt Biocontrol), acide eating Darfot bacteria RAY209 (ATCC PTA-4249；WO 2003/57861；Such as BIOBOOST, from Brett Young, Winnipeg, Canada), Dilophosphora alopecuri (twists with the fingers fungus, from Australia BASF Agricultural Specialties Pty Ltd), brown seaweed (Sargassum) extract (such as KELPAK SL, from South Africa Kelp Products Ltd), formononetin (such as MYCONATE, from Plant Health Care plc, U.K.), point fusarium is (such asFrom Italy S.I.A.P.A.,From France Natural Plant Protection), clump branch bacterium Mycorrhiza fungi (such as MYC 4000, from France ITHEC), AMF RTI-801 is (such as MYKOS, from Xtreme Gardening, USA or RTI Reforestation Technologies International；USA), (such as BC-1000, from Chile for grapefruit seed and pulp extract Chemie S.A.), (such as MESSENGER or HARP-N-Tek comes harpin (alpha-beta) albumen From Plant Health Care plc, U.K.；Science 257,1-132,1992), bollworm caryogram (such as HELICOVEX, from Switzerland Adermatt for polyhedrosis virus (HearNPV) Biocontrol), Heterorhabditis bacteriophora-NJ is (such asG, from BASF Agricultural Specialities Limited, UK), fumosorosea Apopka-97 (ATCC 20874)(PFR-97TM, from Certis LLC, USA), LINL-OX (US 8,221,736), (such as VACCIPLANT, from Laboratoires Goemar, St.Malo, method for laminarin State or SwitzerlandSA), Lecanicillium longisporum KV42 and KV71 is (such asFrom Holland Koppert BV), L.muscarium KV01 (is once called as lecanium wheel Branch bacterium) (such as MYCOTAL, from Holland Koppert BV), the molten bacillus of antibiotic 13-1 (Biological Control 45,288-296,2008), antibiotic molten bacillus HS124 (Curr. Microbiol.59 (6), 608-615,2009), produce mould molten bacillus 3.1T8 (Microbiol.Res.158, 107-115；Biological Control 31 (2), 145-154,2004), Metarhizium anisopliae locust mutation IMI 330189 (is separated by Ornithacris cavroisi at Niger；NRRL 50758) (such as GREENFrom South Africa BASF Agricultural Specialities (Pty) Ltd.), Metarhizium anisopliae locust mutation FI-985 (such as GREENSC, from Australia BASF Agricultural Specialties Pty Ltd), Metarhizium anisopliae FI-1045 is (such asFrom Australia BASF Agricultural Specialties Pty Ltd), Gold Testudinis Sub-green muscardine fungus F52 (DSM 3884, ATCC 90448；Such asCanada Novozymes Biologicals BioAg Group), Metarhizium anisopliae ICIPE 69 is (such as METATHRIPOL, from Kenya Nairobi ICIPE), drupe prunus mume (sieb.) sieb.et zucc. strange yeast (NRRL Y-30752；Such asFrom Israel Agrogreen, existing by Germany Bayer CropSciences distributes；US 6,994,849), Microdochium dimerum is (such asFrom France Agrauxine), small spherical shell spore P130A (ATCC 74412,1993 The Folium Mali pumilae that year is discarded orchard by Quebec, CAN St-Joseph-du-Lac separates；Mycologia 94 (2), 297-301,2002), the white aerogenesis initially separated from cinnamon bark at Honduras is mould QST 20799 (such as development MuscudorTMOr QRD300, from AgraQuest, USA), Neem oil is (such as70EC, from Certis LLC, USA), Nomuraea rileyi strain SA86101, GU87401, SR86151, CG128 and VA9101, rose Dark brown Paecilomyces varioti FE 9901 (such as NO FLYTM, from Natural Industries, Inc., USA), Paecilomyces lilacinus 251 is (such asFrom Germany Prophyta；Crop Protection 27,352-361,2008；Initially separate from the line eggs infected in Philippine), pale purple Color Paecilomyces varioti DSM 15169 is (such asSC, from Colombia Live Systems Technology S.A.), paecilomyces lilacinus BCP2 (NRRL 50756；Such as PL GOLD, From South Africa BASF Agricultural Specialities (Pty) Ltd.), bacillus alvei (such as BAC-UP, from south for the mixture of NAS6G6 (NRRL B-50755) and Bacillus pumilus Non-BASF Agricultural Specialities (Pty) Ltd.), pantoea agglomerans (Pantoea vagans) is (old Claim agglomerans)) C9-1 is (initially in 1994 by stem of Fructus Mali pumilae separate tissue；BlightBanFrom NuFrams America Inc., USA, for preventing and treating fire blast in Fructus Mali pumilae； J.Bacteriol.192 (24) 6486-6487,2010), Pasteurella ATCC PTA-9643 (WO 2010/085795), Pasteurella ATCC SD-5832 (WO 2012/064527), intends Si Zhawaba Family name bacillus (WO 2010/80169), puncture pasteurella (US 5,248,500), P.ramose (WO 2010/80619), P.thornea (WO 2010/80169), P.usgae (WO 2010/80169), than Lay penicillium sp (such as JumpFrom Canada Novozymes Biologicals BioAg Group, initially the soil from south Alberta separates；Fertilizer Res.39,97-103,1994), Big photovoltaicing leather bacteria is (such asFrom Finland Verdera Oy), Pichia anomala WRL-076(NRRL Y-30842；US 8,206,972), potassium bicarbonate is (such asCome From SwitzerlandSA), potassium silicate (such as Sil-MATRIXTM, from Certis LLC, USA), Pseudozyma flocculosa PF-A22UL is (such asFrom Canada Plant Products Co.Ltd.), and Rhodopseudomonas DSM 13134 (WO 2001/40441, such as PRORADIX, from Sourcon Padena GmbH&Co.KG, Hechinger Str.262, 72072T ü bingen, Germany), P.chloraphis MA 342 (such as CERALL or CEDEMON, from BioAgri AB, Uppsala, Sweden), pseudomonas fluorescens CL 145A (example Such as ZEQUANOX, from Marrone BioInnovations, Davis, CA, USA；J. Invertebr.Pathol.113 (1): 104-14,2013), pythium oligandrum DV 74 (ATCC 38472； Such asFrom Remeslo SSRO, Biopreparaty, Czech Republic And GOWAN, USA；US 2013/0035230), Reynoutria sachlinensis extract (example AsSC, from Marrone BioInnovations, Davis, CA, USA), Rhizobium leguminosarum Kidney bean biotype (such as RHIZO-STICK, from BASF Corp., USA), Rhizobium leguminosarum Herba Trifolii Pratentis biotype (R.l.bv.trifolii) RP113-7 (such as DORMAL, from BASF Corp., USA；Appl.Environ.Microbiol.44 (5), 1096-1101), R.l.bv. Viciae P1NP3Cst (also referred to as 1435；New Phytol 179 (1), 224-235,2008；Such as NODULATOR PL Peat Granule, from BASF Corp., USA；Or NODULATOR XL PL b, from Canada BASF Agricultural Specialties Ltd.), (such as NODULAID Group E, from Australia BASF for R.l.bv.viciae SU303 Agricultural Specialties Pty Ltd), R.l.bv.viciae WSM1455 is (such as NODULAID Group F, from Australia BASF Agricultural Specialties Pty Ltd), R.tropici SEMIA 4080 (is equal to PRF 81；Soil Biology&Biochemistry 39,867-876,2007), also referred to as bacterial strain 2011 or RCR2011 (Mol Gen Genomics 272: 1-17,2004；Such as DORMAL ALFALFA, from BASF Corp., USA；Gold, from Canada Novozymes Biologicals BioAg Group) Sinorhizobium meliloti MSDJ0848 (France INRA), Sphaerodes Mycoparasitica IDAC 301008-01 (WO 2011/022809), spodoptera polyhedrosis Virus (SpliNPV) (such as LITTOVIR, from Switzerland Adermatt Biocontrol), Si Shi is little Volume moth nematicide is (such asFrom BASF Agricultural Specialities Limited, UK), Si Shi noctuid nematicide (From BioWorks, Inc., USA；From BASF Agricultural Specialities Limited, UK), Sawfly nematicide L137 (L, from BASF Agricultural Specialities Limited, UK), streptomyces griseoviridus K61 is (such asFrom Verdera Oy, Espoo, Finland；Crop Protection 25,468-475,2006), streptomyces lydicus WYEC 108 (such asFrom Natural Industries, Inc., USA, US 5,403,584), Streptomyces violaceoniger YCED-9 is (such asFrom Natural Industries, Inc., USA, US 5,968,503), Tarlaromyces flavus V117b is (such asFrom Germany Prophyta), Trichoderma asperellum SKT-1 is (such asFrom Japan Kumiai Chemical Industry Co., Ltd.), Trichoderma asperellum ICC 012 (such as TENET WP, REMDIER WP, BIOTEN WP, from Isagro NC, USA, BIO-TAM, from AgraQuest, USA), dark green Trichoderma spp. LC52 is (such asFrom Agrimm Technologies Ltd, NZ), deeply (such as Esquive WG, from France Agrauxine S.A., such as green trichoderma CNCM I-1237 Wound disease on antagonism glucose rattan and plant roots pathogen), push up spore Trichoderma spp. JM41R (NRRL 50759； Such as RICHPLUSTM, from South Africa BASF Agricultural Specialities (Pty) Ltd.), Lid nurse this Trichoderma spp. ICC 080 (such as TENET WP, REMDIER WP, BIOTEN WP, From Isagro NC, USA, BIO-TAM, from AgraQuest, USA), Trichoderma harzianum T-22 is (such asFrom Firma BioWorks Inc., USA), breathe out thatch wood Mould TH 35 (such as ROOTFrom Israel Mycontrol Ltd.), Trichoderma harzianum T-39 is (such asAnd TRICHODERMAFrom Israel Mycontrol Ltd. and Israel Makhteshim Ltd.), Trichoderma harzianum and the mixture of Trichoderma viride (such as TRICHOPEL, from Agrimm Technologies Ltd, NZ), Trichoderma harzianum ICC012 and Trichoderma viride ICC080 is (such asWP, from Italy Isagro Ricerca), porous Trichoderma spp. and Trichoderma harzianum are (such asFrom Sweden BINAB Bio-Innovation AB), hook Trichoderma spp. is (such asFrom Brazil C.E.P.L.A.C.), Green trichoderma GL-21 is (such asFrom Certis LLC, USA), Trichoderma viride (example AsFrom India Ecosense Labs. (India) Pvt.Ltd.,F, From India T.Stanes&Co.Ltd.), Trichoderma viride TV1 (such as Trichoderma viride TV1, from Italy Agribiotec srl) and the graceful thin base lattice spore HRU3 of Order is (such asCome From Botry-Zen Ltd, NZ).
Bacterial strain can be derived from genetic resources and preservation center: American Type Culture Collection, 10801University Blvd., Manassas, VA 20110-2209, USA (bacterium Strain has prefix ATCC)；CABI Europe-International Mycological Institute, Bakeham Lane, (bacterial strain has prefix for Egham, Surrey, TW20 9TYNRRL, UK CABI and IMI)；Centraalbureau voor Schimmelcultures, Fungal Biodiversity Centre, Uppsalaan 8, PO Box 85167,3508AD Utrecht, lotus Blue (bacterial strain has prefix CBS)；Division of Plant Industry, CSIR O, Canberra, Australia's (bacterial strain has prefix CC)；Collection Nationale de Cultures de Microorganismes, Institut Pasteur, 25rue du Docteur Roux, F-75724 PARIS Cedex 15 (bacterial strain has prefix CNCM)；Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Inhoffenstra β e 7B, 38124Braunschweig, Germany's (bacterial strain has prefix DSM)；International Depositary Authority of Canada Collection, Canada's (bacterial strain has prefix IDAC)； Interntional Collection of Micro-orgniasms from Plants, Landcare Research, Private Bag 92170, Auckland Mail Centre, Auckland 1142, New Zealand's (bacterial strain has prefix ICMP)；IITA, PMB 5320, Ibadan, Nigeria (bacterium Strain has prefix IITA)；The National Collections of Industrial and Marine Bacteria Ltd., Torry Research Station, P.O.Box 31,135Abbey Road, Aberdeen, AB98DG, Scotland (bacterial strain has prefix NCIMB)；ARS Culture Collection of the National Center for Agricultural Utilization Research, Agricultural Research Service, U.S.Department of Agriculture, 1815 North University Street, (bacterial strain has prefix for Peoria, Illinois 61604, USA NRRL)；Department of Scientific and Industrial Research Culture Collection, Applied Biochemistry Division, Palmerston North, New Zealand (bacterium Strain has prefix NZP)；Estadual de Pesquisa Agropecu á ria, RuaDias, 570, Bairro Menino Deus, Porto Alegre/RS, Brazil's (bacterial strain has prefix SEMIA)；SARDI, Adelaide, South Australia (bacterial strain has prefix SRDI)；U.S.Department of Agriculture, Agricultural Research Service, Soybean and Alfalfa Research Laboratory, BARC-West, 10300Baltimore Boulevard, Building 011, Beltsville, MD 20705, USA (bacterial strain has prefix USDA:Beltsville Rhizob.Culture Coll.Catalog March 1987USDA-ARS ARS-30: http://pdf.usaid.gov/pdf_docs/PNAAW891.pdf)；And Murdoch University, Perth, Western Australia (bacterial strain has prefix WSM).Other bacterial strains can be at the Global Catalogue of Microorganisms:http: //gcm.wfcc.info/ and Http:// www.landcareresearch.co.nz/resources/collections/icmp finds and goes forward side by side The bacterial strain preservation of one step reference http://refs.wdcm.org/collections.htm and prefix thereof.
Bacillus amyloliquefaciens plant subspecies MBI600 (NRRL B-50595) are withered to have bacterial strain code The numbering NRRL B-50595 preservation of grass bacillus cereus 1430 (and being equal to NCIMB 1237).Closely Have been based on over Nian to depend on conventional tool (such as method based on culture) and molecular tool (such as gene Typing and fatty acid analysis) mixing classical micro-biological process combination heterogeneous test by MBI 600 are re-classified as bacillus amyloliquefaciens plant subspecies.Therefore, bacillus subtilis MBI600 (or MBI 600 or MBI-600) it is equal to bacillus amyloliquefaciens plant subspecies MBI600, it is withered in the past Grass bacillus cereus MBI600.By Int.J.Microbiol.Res.3 (2) (2011), 120-130 is known MBI600 is the rice inorganic agent promoting plant growing, and it is further described in such as US In 2012/0149571A1.This bacterial strain MBI600 is such as liquid dosage product Commercial (BASF Corp., USA).
Bacillus subtilis strain FB17 is initially separated (System.Appl. in North America by Herba Gynurae bicoloris root Microbiol.27,372-379,2004).FB17 promotes plant health (US 2010/0260735； WO 2011/109395).Bacillus subtilis FB17 the most on April 26th, 2011 with PTA-11857 is preserved in ATCC.FB17 is properly termed as UD1022 or UD10-22 in elsewhere.
Bacillus amyloliquefaciens AP-136 (NRRL B-50614), bacillus amyloliquefaciens AP-188 (NRRL B-50615), bacillus amyloliquefaciens AP-218 (NRRL B-50618), Xie Dian Afnyloliquefaciens AP-219 (NRRL B-50619), bacillus amyloliquefaciens AP-295 (NRRL B-50620), Japan slowly the most raw root nodule bacteria SEMIA 5079 (such as GELFIX 5 or ADHERE 60, From Brazil BASF Agricultural Specialties Ltd.), the slow raw root nodule bacteria SEMIA of Japan 5080 (such as GELFIX 5 or ADHERE 60, from Brazil BASF Agricultural Specialties Ltd.), Mo Haiwei bacillus cereus AP-209 (NRRL B-50616), solonchak bacillus cereus AP-217 (NRRL B-50617), strain of i (bacillus) pumilus INR-7 (also referred to as BU-F22 (NRRL B-50153) and BU-F33 (NRRL B-50185)), simple bacillus cereus ABU 288 (NRRL B-50340) and bacillus amyloliquefaciens plant subspecies MBI600 (NRRL B-50595) the most US 2012/0149571, US 8,445,255, WO 2012/079073 mentions.
(1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate or salt (jasmone hydrochlorate) or derivant include but not limited to (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate potassium, jasmine Keto acid sodium, (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate lithium, (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate ammonium, (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate Dimethyl Ammonium, (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate isopropyl Ammonium, (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate diethanol ammonium, (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate diethyl triethanol ammonium, methyl jasmonate, jasmine Keto acid amide, (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate methyl nitrosourea, (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate-l-amino acid (amide connects) conjugate The conjugate of ILE, Valine, L-Leu or L-phenylalanine (such as with), 12- The acid of oxo phytadiene, coronatine, coronafacoyl-L-serine, coronafacoyl-L-revives ammonia Acid, the methyl ester of 1-oxoindane acyl isoleucine, the leucic methyl ester of 1-oxoindane acyl, coronalon (2-[(6-ethyl-1-oxo-1,2-dihydroindene-4-carbonyl) amino]-3 methylvaleric acid methyl ester), linoleic acid or Its derivant and LINL-OX, or the combination of any of the above-described material.
Humate is the humic acid and Fu Li extracted by the brown coal and clay form being known as leonardite Acid.Humic acid is to be present in having in humus and other organic derived materials such as peat and other bituminous coal Machine acid.Have shown that they improve fertilizer efficiency in the phosphate and micronutrient absorption of plant and auxiliary is planted Thing root system development.
An embodiment according to inventive mixture, this at least one pesticide II is selected from L1)-L6) Group:
L1) there is antifungal, bactericidal, kill the virus and/or the microbial pesticide of plant defense activator activity: White lead parasitism spore M-10 (L.1.1), Aspergillus flavus NRRL 21882 (L1.2), Aureobasidium pullulans DSM 14940 (L1.3), Aureobasidium pullulans DSM 14941 (L.1.4), bacillus amyloliquefaciens AP-136 (NRRL B-50614) (L.1.5), bacillus amyloliquefaciens AP-188 (NRRL B-50615) (L.1.6), bacillus amyloliquefaciens AP-218 (NRRL B-50618) (L.1.7), solution Bacillus amyloliquefaciens AP-219 (NRRL B-50619) (L.1.8), bacillus amyloliquefaciens AP-295 (NRRL B-50620) (L.1.9), bacillus amyloliquefaciens FZB42 (L.1.10), solution Bacillus amyloliquefaciens IN937a (L.1.11), bacillus amyloliquefaciens IT-45 (CNCM I-3800) (L.1.12), bacillus amyloliquefaciens plant subspecies MBI600 (NRRL B-50595) (L.1.13), Mo Haiwei bacillus cereus AP-209 (NRRL B-50616) (L.1.15), Bacillus pumilus INR-7 (NRRL B-50153；NRRL B-50185) (L.1.14), short and small Bacillus cereus KFP9F (L.1.15), Bacillus pumilus QST 2808 (NRRL B-30087) (L.1.16), Bacillus pumilus GHA 181 (L.1.17), simple bacillus cereus ABU 288 (NRRL B-50340) (L.1.18), solonchak bacillus cereus AP-217 (NRRL B-50617) (L.1.19), bacillus subtilis CX-9060 (L.1.20), bacillus subtilis FB17 (L.1.74), bacillus subtilis GB03 (L.1.21), bacillus subtilis GB07 (L.1.22), bacillus subtilis QST-713 (NRRL B-21661) (L.1.23), Xie Dian Powder Bacillus subtilis var FZB24 (L.1.24), solution starch Bacillus subtilis var D747 (L.1.25), Fructus Canarii albi candida mycoderma I-82 (L.1.26), Fructus Canarii albi candida mycoderma O (L.1.27), Antagonism yeast (L.1.28), Tomato Caused by Clavibacter michiganensis subsp. michiganensis (phage) (L.1.29), shield shell are mould CON/M/91-08 (L.1.30), Cryphonectria parasitica (L.1.31), cryptococcus albidus (L.1.32), Dilophosphora alopecuri (L.1.33), point fusarium (L.1.34), Clonostachys rosea F.catenulata J1446 (L.1.35), Gliocladium roseum 321U (L.1.36), the strange yeast of drupe prunus mume (sieb.) sieb.et zucc. NRRL Y-30752 (L.1.37), Microdochium dimerum (L.1.38), small spherical shell spore P130A (L.1.39), the white mould QST of aerogenesis 20799 (L.1.40), Paenibacillus polymyxa PKB1 (ATCC 202127) (L.1.41), pantoea agglomerans C9-1 (L.1.42), big photovoltaicing leather bacteria (L.1.43), Pichia anomala WRL-76 (L.1.44), Pseudozyma flocculosa PF-A22UL (L.1.45), pythium oligandrum DV 74 (L.1.46), Sphaerodes Mycoparasitica IDAC 301008-01 (L.1.47), streptomyces griseoviridus K61 (L.1.48), profit Enlightening streptomycete WYEC 108 (L.1.49), Streptomyces violaceoniger XL-2 (L.1.50), Streptomyces violaceoniger YCED-9 (L.1.51), Tarlaromyces flavus V117b (L.1.52), Trichoderma asperellum T34 (L.1.53), spine Spore Trichoderma spp. SKT-1 (L.1.54), Trichoderma asperellum ICC 012 (L.1.55), Trichoderma atroviride LC52 (L.1.56), Trichoderma atroviride CNCM I-1237 (L.1.57), top spore Trichoderma spp. JM41R (L.1.58), lid nurse this Trichoderma spp. ICC 080 (L.1.59), T.harmatum TH 382 (L.1.60), Trichoderma harzianum TH-35 (L.1.61), Trichoderma harzianum T-22 (L.1.62), Ha Ci Trichoderma spp. T-39 (L.1.63)；Trichoderma harzianum ICC012's and Trichoderma viride ICC080 (L.1.64) is mixed Compound；Porous Trichoderma spp. and the mixture of Trichoderma harzianum (L.1.65)；Hook Trichoderma spp. (L.1.66), green trichoderma GL-21 (L.1.67), green trichoderma G41 (L.1.68), Trichoderma viride TV1 (L.1.69), Typhula Phacorrhiza 94671 (L.1.70), graceful thin base lattice spore HRU3 (L.1.71) of Order, the most beautiful take turns branch Bacterium (L.1.72), little zucchini yellow mosaic virus (avirulent strains) (L.1.73)；
L2) there is antifungal, bactericidal, kill the virus and/or the bioid of plant defense activator activity is learned to farm Medicine: chitosan (hydrolyzate) (L.2.1), Harpin albumen (L.2.2), laminarin (L.2.3), herring oil (L.2.4), natamycin (L.2.5), plumpox virus coat protein (L.2.6), Potassium bicarbonate (L.2.7), Reynoutria sachalinensis extract (L.2.8), salicylic acid (L.2.9), potassium bicarbonate or sodium (L.2.10), tea tree oil (L.2.11)；
L3) there is parasite killing, mite killing, kill the microbial pesticide of spiral shell and/or eelworm-killing activity: radiation soil bar Bacterium K1026 (L.3.1), agrobacterium radiobacter K84 (L.3.2), bacillus firmus I-1582(L.3.3)；Bacillus thuringiensis strain ABTS-1857 (L.3.4), SAN 401I (L.3.5), ABG-6305 (L.3.6) and ABG-6346 (L.3.7)；Bacillus thuringiensis Israel subclass AM65-52 (L.3.8), bacillus thuringiensis subsp israelensis SUM-6218 (L.3.9), bacillus thuringiensis galleria mellonella waxmoth subspecies SDS-502 (L.3.10), Su Yunjin Bacillus cereus Kurstaki EG 2348 (L.3.11), bacillus thuringiensis Kustak are sub- Plant SB4 (L.3.12), bacillus thuringiensis Kurstaki ABTS-351 (HD-1) (L.3.13), beauveria bassiana ATCC 74040 (L.3.14), ball spore are white Stiff bacterium GHA (L.3.15), beauveria bassiana H123 (L.3.16), beauveria bassiana DSM 12256 (L.3.17), beauveria bassiana PPRI 5339 (L.3.18), muscardine (L.3.19), Bulkholderia cepasea A396 (L.3.20), Chromobacterium subtsugae PRAA4-1 (L.3.21), carpocapsa pomonella granulosis virus V22 (L.3.22), carpocapsa pononella granule Precursor virus V1 (L.3.23), pseudo-carpocapsa pomonella granulosis virus (CrleGV) (L.3.57), bollworm Nuclear polyhedrosis virus (HearNPV) (L.3.58), fumosorosea Apopka-97(L.3.24)、Lecanicillium longisporum KV42(L.3.25)、L. Longisporum KV71 (L.3.26), L.muscarium KV01 (L.3.27), the green deadlock of chafer Bacterium FI-985 (L.3.28), Metarhizium anisopliae FI-1045 (L.3.29), Metarhizium anisopliae F52 (L.3.30), Metarhizium anisopliae ICIPE 69 (L.3.31), Metarhizium anisopliae locust mutation IMI 330189(L.3.32)；Nomuraea rileyi strain SA86101 (L.3.33), GU87401 (L.3.34), SR86151 (L.3.35), CG128 (L.3.36) and VA9101 (L.3.37)； Paecilomyces fumosoroseus FE 9901 (L.3.38), paecilomyces lilacinus 251 (L.3.39), lavender are intended Penicillium sp DSM 15169 (L.3.40), paecilomyces lilacinus BCP2 (L.3.41), Japanese beetle class bud Spore bacillus Dutky-1940 (NRRL B-2309=ATCC 14706) (L.3.42), Japanese beetle class Bacillus cereus Dutky 1 (L.3.43), Japanese beetle series bacillus KLN 3 (L.3.56), Pasteur Bacillus Ph3 (L.3.44), Pasteurella ATCC PTA-9643 (L.3.45), pasteurellosis bacillus Belong to ATCC SD-5832 (L.3.46), intend Si Zhawa pasteurellosis bacillus PN-1 (L.3.46), puncture bar Family name bacillus (L.3.47), P.ramosa (L.3.48), P.Reneformis Pr-3 (L.3.49), P. Thornea (L.3.50), P.usgae (L.3.51), pseudomonas fluorescens CL 145A (L.3.52), Spodoptera nuclear polyhedrosis virus (SpliNPV) (L.3.59), Si Shi Little space (L.3.53), Si Shi noctuid nematicide (L.3.54), sawfly nematicide L137 (L.3.55)；
L4) there is parasite killing, mite killing, kill the biochemical pesticides of spiral shell, pheromone and/or eelworm-killing activity: L- Carvone (L.4.1), citral (L.4.2), acetic acid (E, Z)-7,9-12 carbon diene-1-base ester (L.4.3), Ethyl formate (L.4.4), (E, Z)-2,4-decatrienoic acid ethyl ester (pear ester) (L.4.5), (Z, Z, E)-7,11,13-16 carbon three olefine aldehydr (L.4.6), butanoic acid heptyl ester (L.4.7), myristic acid isopropyl Ester (L.4.8), LINL-OX (L.4.9), a thousand li acid Garden lavender ester (L.4.10), 2-methyl-1-butene Alcohol (L.4.11), methyleugenol (L.4.12), methyl jasmonate (L.4.13), (E, Z)-2,13- 18 carbon diene-1-alcohol (L.4.14), (E, Z)-2,13-18 carbon diene-1-alcohol acetic ester (L.4.15), (E, Z)-3,13-18 carbon diene-1-alcohol (L.4.16), R-1-octene-3-alcohol (L.4.17), Coptotermes formosanus Shtrari. information Element (L.4.18), potassium silicate (L.4.19), Sorbitol caprylate (L.4.20), acetic acid (E, Z, Z)-3,8,11-14 carbon trialkenyl ester (L.4.21), acetic acid (Z, E)-9,12-14 carbon diene-1- Base ester (L.4.22), Z-7-tetradecene-2-ketone (L.4.23), acetic acid Z-9-tetradecene-1-base ester (L.4.24), Z-11-fulure (L.4.25), Z-11-tetradecene-1-alcohol (L.4.26), gold Albizzia julibrissin extract (L.4.27), grapefruit seed and pulp extract (L.4.28), Chenopodium Ambrosiodae extract (L.4.29), Catnip oil (L.4.30), Neem oil (L.4.31), Quillaia saponaria extract (L.4.32), Flos Tagetis Erectae oil (L.4.33)；
L5) there is plant stress reduction, plant growth regulator, plant growing promotion and/or output increased live The microbial pesticide of property: agalactia azospirillum BR 11140 (SpY2T) (L.5.1), azospirillum brasilense Spirillum AZ39 (L.5.2), Azospirillum brasilense XOH (L.5.3), Azospirillum brasilense BR 11005 (Sp245) (L.5.4), Azospirillum brasilense BR 11002 (L.5.5), raw fat azospirillum BR 11646 (Sp31) (L.5.6), Irakense (L.5.7), high salt azospirillum (L.5.8), Bradyrhizobium PNL01 (L.5.9), Bradyrhizobium (Arachis) CB1015 (L.5.10), Bradyrhizobium (Arachis) USDA 3446 (L.5.11), Bradyrhizobium (Arachis) SEMIA 6144 (L.5.12), Bradyrhizobium (Arachis) SEMIA 6462 (L.5.13), Bradyrhizobium (Arachis) SEMIA 6464 (L.5.14), Bradyrhizobium (Vigna) (L.5.15), Erichsen the most raw root nodule bacteria SEMIA 587 (L.5.16), Erichsen are taken root tumor slowly Bacterium SEMIA 5019 (L.5.17), Erichsen the most raw root nodule bacteria U-1301 (L.5.18), Erichsen are given birth to slowly Root nodule bacteria U-1302 (L.5.19), Erichsen the most raw root nodule bacteria USDA 74 (L.5.20), Erichsen are given birth to slowly Root nodule bacteria USDA 76 (L.5.21), Erichsen the most raw root nodule bacteria USDA 94 (L.5.22), Erichsen are slow Raw root nodule bacteria USDA 3254 (L.5.23), the slow raw root nodule bacteria 532c (L.5.24) of Japan, Japan are slowly Raw root nodule bacteria CPAC 15 (L.5.25), the slow raw root nodule bacteria E-109 (L.5.26) of Japan, the slow life of Japan Root nodule bacteria G49 (L.5.27), the slow raw root nodule bacteria TA-11 (L.5.28) of Japan, Japan are taken root tumor slowly Bacterium USDA 3 (L.5.29), the slow raw root nodule bacteria USDA 31 (L.5.30) of Japan, Japan are taken root tumor slowly Bacterium USDA 76 (L.5.31), the slow raw root nodule bacteria USDA 110 (L.5.32) of Japan, Japan take root slowly Tumor bacterium USDA 121 (L.5.33), the slow raw root nodule bacteria USDA 123 (L.5.34) of Japan, Japan are slowly Raw root nodule bacteria USDA 136 (L.5.35), Japan's slow raw root nodule bacteria SEMIA 566 (L.5.36), day This slow raw root nodule bacteria SEMIA 5079 (L.5.37), the slow raw root nodule bacteria SEMIA of Japan 5080 (L.5.38), Japan slow raw root nodule bacteria WB74 (L.5.39), the most raw root nodule bacteria in Liaoning (L.5.40), late feathering fan bean root nodule bacteria LL13 (L.5.41), late feathering fan bean root nodule bacteria WU425 (L.5.42), late feathering fan bean root nodule bacteria WSM471 (L.5.43), late feathering fan Radix Sophorae Tonkinensis Tumor bacterium WSM4024 (L.5.44), AMF RTI-801 (L.5.45), middle raw root nodule bacteria Belong to raw in WSM1271 (L.5.46), middle raw rhizobium WSM1497 (L.5.47), chickpea Root nodule bacteria CC1192 (L.5.48), M.huakii (L.5.49), Mesorhizobium loti CC829 (L.5.50), Mesorhizobium loti SU343 (L.5.51), bacillus alvei NAS6G6 (L.5.52), than Lay penicillium sp (L.5.53), rhizobium leguminosarum Kidney bean biotype RG-B10 (L.5.54), rhizobium leguminosarum Herba Trifolii Pratentis biotype RP113-7 (L.5.55), Semen Pisi sativi root Tumor bacterium Herba Trifolii Pratentis biotype 095 (L.5.63), rhizobium leguminosarum Herba Trifolii Pratentis biotype TA1 (L.5.64), rhizobium leguminosarum Herba Trifolii Pratentis biotype CC283b (L.5.65), rhizobium leguminosarum Herba Trifolii Pratentis biotype CC275e (L.5.66), rhizobium leguminosarum Herba Trifolii Pratentis biotype CB782 (L.5.67), rhizobium leguminosarum Herba Trifolii Pratentis biotype CC1099 (L.5.68), pea root nodule Bacterium Herba Trifolii Pratentis biotype WSM1325 (L.5.69), R.l.bv.viciae SU303 (L.5.56), R. l.bv.viciae WSM1455(L.5.57)、R.l.bv.viciae P1NP3Cst(L.5.58)、R.l. bv.viciae RG-P2(L.5.70)、R.tropici SEMIA 4080(L.5.59)、R.tropici SEMIA 4077(L.5.71)、R.tropici CC511(L.5.72)、Sinorhizobium meliloti MSDJ0848(L.5.60)、S.meliloti NRG185(L.5.61)、S.meliloti RRI128(L.5.62)；
L6) there is plant stress reduction, plant growth regulator and/or plant products and carry highly active bioid Learn to farm medicine: abscisic acid (L.6.1), aluminium silicate (Kaolin) (L.6.2), 3-decen-2-one (L.6.3), Formononetin (L.6.4), isoflavone element (L.6.5), hesperetin (L.6.6), high rape plain lactone (L.6.7), humic acid esters (L.6.8), methyl jasmonate (L.6.9), LINL-OX (L.6.10), Lysophosphatidyl ethanolamine (L.6.11), naringenin (L.6.12), polymeric polyhydroxy acid (L.6.13), Salicylic acid (L.6.14), yellow tang (Norway Sargassum, Brown algae) extract (L.6.15) and brown seaweed (Ecklonia maxima (Sargassum)) extract (L.6.16).
Additionally, the present invention relates to agrochemical composition, it comprises (component 1) and at least one is selected from L) biological pesticide (component 2) organized, especially at least a kind of selected from L1 as above) and L2) organize The mixture of other antifungal biological pesticides, and at least one suitable auxiliary agents if necessary.
Further preferably comprising selected from L1) biological pesticide organized is as the mixture of pesticide II (component 2), this group Biological pesticide is preferably selected from bacillus amyloliquefaciens AP-136 (NRRL B-50614 and B-50330), Bacillus amyloliquefaciens AP-188 (NRRL B-50615 and B-50331), bacillus amyloliquefaciens AP-218 (NRRL B-50618), bacillus amyloliquefaciens AP-219 (NRRL B-50619 and B-50332), bacillus amyloliquefaciens AP-295 (NRRL B-50620 and B-50333), solve starch bud Spore bacillus IT-45 (CNCM I-3800), bacillus amyloliquefaciens plant subspecies MBI600 (NRRL B-50595), Mo Haiwei bacillus cereus AP-209 (NRRL B-50616), Bacillus pumilus INR-7(NRRL B-50153；NRRL B-50185), Bacillus pumilus KFP9F, short and small bud Spore bacillus QST 2808 (NRRL B-30087), Bacillus pumilus GHA 181, simple spore bar Bacterium ABU 288 (NRRL B-50340), solonchak bacillus cereus AP-217 (NRRL B-50617) are withered Grass bacillus cereus CX-9060, bacillus subtilis FB17, bacillus subtilis GB03, hay bud Spore bacillus GB07, bacillus subtilis QST-713 (NRRL B-21661), solve starch hay spore Bacillus mutation FZB24, solves starch Bacillus subtilis var D747, bacillus alvei NAS6G6, Paenibacillus polymyxa PKB1 (ATCC 202127), Sphaerodes mycoparasitica IDAC 301008-01 and top spore Trichoderma spp. JM41R；Even more preferably selected from bacillus amyloliquefaciens AP-136 (NRRL B-50614), bacillus amyloliquefaciens AP-188 (NRRL B-50615), Xie Dian Afnyloliquefaciens AP-218 (NRRL B-50618), bacillus amyloliquefaciens AP-219 (NRRL B-50619), bacillus amyloliquefaciens AP-295 (NRRL B-50620), bacillus amyloliquefaciens IT-45 (CNCM I-3800), bacillus amyloliquefaciens plant subspecies MBI600 (NRRL B-50595), Mo Haiwei bacillus cereus AP-209 (NRRL B-50616), Bacillus pumilus INR-7 (NRRL B-50153；NRRL B-50185), Bacillus pumilus QST 2808 (NRRL B-30087), letter Single bacillus cereus ABU 288 (NRRL B-50340), bacillus subtilis FB17, bacillus subtilis Bacterium QST-713 (NRRL B-21661), bacillus alvei NAS6G6, Sphaerodes Mycoparasitica IDAC 301008-01 and top spore Trichoderma spp. JM41R.
An embodiment according to inventive mixture, this at least one pesticide II is for solving starch spore Bacillus plant subspecies MBI600.These mixture are the most suitable in Semen sojae atricolor.
According to the another embodiment of inventive mixture, this at least one pesticide II is short and small spore bar Bacterium INR-7.These mixture are the most suitable in Semen sojae atricolor and Semen Maydis.
According to another embodiment, this at least one pesticide II is simple bacillus cereus, preferably simple bud Spore bacillus ABU 288.These mixture are the most suitable in Semen sojae atricolor and Semen Maydis.
According to another embodiment, this at least one pesticide II is bacillus subtilis, preferably hay bud Spore bacillus strain FB17.
An embodiment according to inventive mixture, this at least one pesticide II is selected from solving starch bud Spore bacillus AP-136, bacillus amyloliquefaciens AP-188, bacillus amyloliquefaciens AP-218, Xie Dian Afnyloliquefaciens AP-219, bacillus amyloliquefaciens AP-295, bacillus amyloliquefaciens FZB42, Bacillus amyloliquefaciens IN937a, bacillus amyloliquefaciens IT-45, bacillus amyloliquefaciens plant is sub- Plant MBI600, Mo Haiwei bacillus cereus AP-209, Bacillus pumilus GB34, short and small spore bar Bacterium INR-7, Bacillus pumilus KFP9F, Bacillus pumilus QST 2808, short and small spore bar Bacterium GHA 181, simple bacillus cereus ABU 288, solonchak bacillus cereus AP-217, hay spore Bacillus CX-9060, bacillus subtilis FB17, bacillus subtilis GB03, bacillus subtilis GB07, bacillus subtilis QST-713, solve starch Bacillus subtilis var FZB24 and conciliate shallow lake Powder Bacillus subtilis var D747.These mixture are suitable especially in Semen sojae atricolor and Semen Maydis, especially use In seed treatment.
According to another embodiment, this at least one pesticide II is selected from streptomyces, is preferably selected from grayish green Streptomycete, streptomyces lydicus and Streptomyces violaceoniger, be especially selected from bacterial strain streptomyces griseoviridus K61, Li Di Streptomycete WYEC 108, Streptomyces violaceoniger XL-2 and Streptomyces violaceoniger YCED-9.
According to another embodiment, this at least one pesticide II is Sphaerodes mycoparasitica, Preferably S.mycoparasitica IDAC 301008-01 (also referred to as bacterial strain SMCD2220-01).These Mixture is suitable especially in Semen sojae atricolor, Cereal and Semen Maydis, especially Semen Maydis, is particularly useful for preventing and treating red Mildew.
The invention still further relates to following mixture, wherein this at least one pesticide II is selected from following yeast with true Bacterium: white lead parasitism spore, especially strains A Q 10, Aureobasidium pullulans, the most especially bacterial strain The blastopore of DSM14940 or the blastopore of strain DSM 14941 or its mixture；Fructus Canarii albi is false Silk yeast, especially bacterial strain I-182 and O；Shield shell is mould, especially bacterial strain CON/M/91-8；Reduce Annual ryegrass toxicity (ARGT) is a kind of has been infected toxigenic antibacterial by ingesting The domestic animal disease that the annual ryegrass seed fringe of Rathayibacter toxicus causes Dilophosphora alopecuri；Chain spore glues broom bacterium, especially bacterial strain J 1446；The strange yeast of drupe prunus mume (sieb.) sieb.et zucc., Especially bacterial strain NRRL Y-30752, small spherical shell spore, especially bacterial strain P130A, it is used for preventing and treating Herba Marsileae Quadrifoliae Really scab；White aerogenesis is mould, especially bacterial strain QST 20799, Pichia anomala, especially Bacterial strain WRL-076, Pseudozyma flocculosa, especially bacterial strain PF-A22UL；Few male rotten Mould, especially bacterial strain DV74.
The invention still further relates to following mixture, wherein this at least one pesticide II is selected from fungus Trichoderma, Preferred strain Trichoderma asperellum T34, Trichoderma asperellum SKT-1, Trichoderma asperellum ICC 012, Trichoderma atroviride LC52, Trichoderma atroviride CNCM I-1237, push up spore Trichoderma spp. JM41R, lid nurse this Trichoderma spp. ICC 080, T.harmatum TH 382, Trichoderma harzianum TH-35, Trichoderma harzianum T-22, Trichoderma harzianum T-39； Trichoderma harzianum ICC012 and the mixture of Trichoderma viride ICC080；Porous Trichoderma spp. and Trichoderma harzianum Mixture；Hook Trichoderma spp., green trichoderma GL-21, green trichoderma G41 and Trichoderma viride TV1；Especially push up Spore Trichoderma spp. JM41R.
The invention still further relates to following mixture, wherein this at least one pesticide II belongs to selected from thin base lattice spore (Ulocladium) the graceful thin base lattice spore HRU3 of fungus, especially Order.
Further preferably comprising selected from L2) biological pesticide organized is as the mixture of pesticide II (component 2), this group Biological pesticide be preferably selected from chitosan (hydrolyzate), methyl jasmonate, LINL-OX, Laminarin, Reynoutria sachalinensis extract and tea tree oil；Even more preferably selected from jasmine Jasmine keto acid methyl ester and laminarin.
Further preferably comprising selected from L3) biological pesticide organized is as the mixture of pesticide II (component 2), this group Biological pesticide is preferably selected from agrobacterium radiobacter K1026, bacillus firmus I-1582, Su Yunjin Bacillus cereus Kurstaki SB4, beauveria bassiana GHA, beauveria bassiana H123, ball spore Muscardine DSM 12256, beauveria bassiana PPRI 5339, Metarhizium anisopliae locust mutation IMI 330189, Metarhizium anisopliae FI-985, Metarhizium anisopliae FI-1045, Metarhizium anisopliae F52, Metarhizium anisopliae ICIPE 69, paecilomyces lilacinus DSM 15169, paecilomyces lilacinus BCP2, Japanese beetle series bacillus Dutky-1940 (NRRL B-2309=ATCC 14706), Japanese beetle Series bacillus KLN 3 and Japanese beetle series bacillus Dutky 1, even more preferably selected from Su Yun Gold bacillus cereus Kurstaki SB4, beauveria bassiana DSM 12256, beauveria bassiana PPRI 5339, Metarhizium anisopliae locust mutation IMI 330189, Metarhizium anisopliae FI-985, chafer is green Stiff bacterium FI-1045, paecilomyces lilacinus DSM 15169, paecilomyces lilacinus BCP2, Japan's first Insects bacillus cereus Dutky-1940, Japanese beetle series bacillus KLN 3 and Japanese beetle class bud Spore bacillus Dutky 1.
According to another embodiment, this at least one pesticide II is beauveria bassiana, is preferably selected from ball spore Muscardine ATCC 74040, beauveria bassiana GHA, beauveria bassiana H123, beauveria bassiana DSM 12256 and beauveria bassiana PPRI 5339, especially beauveria bassiana PPRI 5339.This A little mixture are particularly suitable for the arthropod of wide scope, as infected various crop (vegetable, Cucurbitaceae Plant, solanaceous vegetables, Fructus Fragariae Ananssae, flowers and ornamental plant, vine, citrus fruit, a kind of fruit, such as apple, pear, etc. and core Fruit etc.) aleyrodid, thrips, acarid, aphid, psoriasis and its stages of development all (ovum, do not become Ripe stage and adult).Recent research have shown that these Antagonism fungal bacterial strains can also effectively be prevented and treated Nut weevil, wireworm (Agriotes spp.) and trypetid (Tephritid), such as Mediterranean fruitfly (Ceratitis Capitata), cherry fruit fly (Rhagoletis cerasi) and dacus oleae (Bactrocera oleae).It Can be used in Semen sojae atricolor and Semen Maydis.
According to another embodiment, this at least one pesticide II is muscardine.
According to another embodiment, this at least one pesticide II is Metarhizium anisopliae or the green deadlock of chafer Bacterium locust mutation, is preferably selected from Metarhizium anisopliae FI-1045, Metarhizium anisopliae F52, and chafer is green Stiff bacterium locust variant strain FI-985 and IMI 330189, especially bacterial strain IMI 330189.These mix Compound is particularly suitable in Semen sojae atricolor and Semen Maydis preventing and treating arthropod.
According to another embodiment, this at least one pesticide II is Lecanicillium sp., preferably selects From Lecanicillium longisporum KV42, L.longisporum KV71 and L. Muscarium KV01。
According to another embodiment, this at least one pesticide II is paecilomyces fumosoroseus, preferred strain FE 9901, is particularly useful for aleyrodid preventing and treating.
According to another embodiment, this at least one pesticide II is selected from Nomuraea rileyi, preferred strain SA86101, GU87401, SR86151, CG128 and VA9101；And paecilomyces lilacinus, Preferred strain 251, DSM 15169 or BCP2, especially BCP2, these bacterial strains are especially prevented and treated and are planted The growth of thing pathogenicity nematicide.
According to another embodiment, this at least one pesticide II is bacillus firmus, preferred strain The spore of CNCM I-1582, is preferred for the seed treatment of Semen sojae atricolor and Semen Maydis with preventing and treating nematicide and elder brother Worm.
According to another embodiment, this at least one pesticide II is bacillus cereus, preferably CNCM The spore of I-1562, is preferred for the seed treatment of Semen sojae atricolor and Semen Maydis with preventing and treating nematicide and insecticide.
According to another embodiment, this at least one pesticide II is bacillus firmus and waxy spore bar The spore of the spore mixture of bacterium, preferably above-mentioned bacterial strains CNCM I-1582 and CNCM I-1562 mixes Compound, is preferred for the seed treatment of Semen sojae atricolor and Semen Maydis with preventing and treating nematicide and insecticide.
According to another embodiment, this at least one pesticide II is selected from bacillus thuringiensis, preferably revives Cloud gold bacillus cereus Aizawa subspecies, even more preferably selected from bacillus thuringiensis strain ABTS-18, SAN 401I, ABG-6305 and ABG-6346, they are to also including that Noctuidae exists Interior different Lepidopteras belong to be planted effectively.
According to another embodiment, this at least one pesticide II is sub-selected from bacillus thuringiensis Israel Kind, preferably AM65-52, SAN 402I and ABG-6164, they are for various Diptera pests, The larva of such as mosquito and nematicide is used.
According to another embodiment, this at least one pesticide II is selected from bacillus thuringiensis Kustak Subspecies, are preferably selected from bacterial strain EG 2348, SB4 and ABTS-351 (HD-1), especially Su Yun gold Bacillus cereus Kurstaki SB4.These bacterial strains are used for preventing and treating lepidopterous larvae, but do not have noctuid Section.
According to another embodiment, this at least one pesticide II intends walking first selected from bacillus thuringiensis Subspecies, preferred strain DSM 2803, NB-125 and NB-176, especially NB-176, they are complete Portion protection plant is such as in case chrysomelid larva.
Further preferably comprising selected from L4) biological pesticide organized is as the mixture of pesticide II (component 2), this group Biological pesticide is preferably selected from methyl jasmonate, Acacia farnesiana Willd. extract, grapefruit seed and pulp extract, Catnip oil, Neem oil, Quillaia saponaria extract and Flos Tagetis Erectae oil, especially methyl jasmonate or Water base Quillaia saponaria extract.
Further preferably comprising selected from L5) biological pesticide organized is as the mixture of pesticide II (component 2), this group Biological pesticide is preferably selected from agalactia azospirillum BR 11140 (SpY2T), Azospirillum brasilense XOH, Azospirillum brasilense BR 11005 (Sp245), Azospirillum brasilense BR 11002, raw fat azospirillum BR 11646 (Sp31), Irakense, high salt azospirillum, Bradyrhizobium (Vigna), The slow raw root nodule bacteria USDA 3 of Japan, the slow raw root nodule bacteria USDA 31 of Japan, the slow raw root nodule bacteria of Japan USDA 76, the slow raw root nodule bacteria USDA 110 of Japan, the slow raw root nodule bacteria USDA 121 of Japan, Japan Slow raw root nodule bacteria TA-11, the slow raw root nodule bacteria 532c of Japan, AMF RTI-801, Nidus Vespae Bacillus cereus NAS6G6, ratio Lay penicillium sp, rhizobium leguminosarum Kidney bean biotype, rhizobium leguminosarum SANYE Grass biotype, R.l.bv.Viciae and Sinorhizobium meliloti；It is more preferably selected from azospirillum brasilense Spirillum BR 11005 (Sp245), Bradyrhizobium (Vigna), the slow raw root nodule bacteria USDA 3 of Japan, The slow raw root nodule bacteria USDA 31 of Japan, the slow raw root nodule bacteria USDA 76 of Japan, the slow raw root nodule bacteria of Japan USDA 110, the slow raw root nodule bacteria USDA 121 of Japan, the slow raw root nodule bacteria TA-11 of Japan, Japan is slow Raw root nodule bacteria 532c, rhizobium leguminosarum Kidney bean biotype P1NP3Cst, rhizobium leguminosarum Kidney bean is biological Type RG-B10, rhizobium leguminosarum Herba Trifolii Pratentis biotype RP113-7, R.l.bv.viciae SU303, R.l.bv.viciae WSM1455, R.tropici SEMIA 4077, R.tropici SEMIA 4080 With Sinorhizobium meliloti.
According to the another embodiment of inventive mixture, the Bradyrhizobium as pesticide II (means Any Bradyrhizobium kind and/or bacterial strain) it is the slow raw root nodule bacteria of Japan.These mixture are Semen sojae atricolor In the most suitable.The slow raw rhizobium strains of Japan uses culture medium known in the art and fermentation technique example As cultivated about 5 days at 27 DEG C in yeast extract-mannitol meat soup (YEM).
The invention still further relates to following mixture, wherein this at least one pesticide II is taken root tumor slowly selected from Japan Bacterium and further inclusion compound III (component 3), wherein compound III selected from (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate or its salt or Derivant, including LINL-OX, preferably methyl jasmonate or LINL-OX.
Various Japan give birth to the source of rhizobium strains slowly and such as award in US 7,262,151 that (Japan takes root slowly Tumor bacteria strain USDA 110 (=IITA 2121, SEMIA 5032, RCR 3427, ARS I-110, Nitragin 61A89；Nineteen fifty-nine is separated by Semen sojae atricolor (Glycine max) at Florida, Serogroup 110；Appl Environ Microbiol 60,940-94,1994), USDA31 (=Nitragin 61A164；Nineteen forty-one is separated by Semen sojae atricolor at Wisoconsin, USA, Serogroup 31), USDA76 (the plant of the bacterial strain USDA 74 separated by Semen sojae atricolor at California, USA for 1956 Passage cell, Serogroup 76), USDA121 (nineteen sixty-five is separated by Semen sojae atricolor at Ohio, USA), USDA3 (is separated by Semen sojae atricolor, Serogroup 6 for 1914 at Virginia, USA；US 7,262,151), USDA 121 (Crop Science 26 (5), 911-916,1986) and USDA 136 (=CB 1809, SEMIA 586, Nitragin 61A136, RCR 3407；1961 at Beltsville, Maryland Separated by Semen sojae atricolor；Appl.Environ.Microbiol.60,940-94,1994).Other Japan are slow raw Rhizobium strains G49 (INRA, France Angers；C.R.Acad.Agric.Fr.73,163-171, 1987) it is especially suitable for being grown in Europe, especially the Semen sojae atricolor of France.Other suitable Japan take root tumor slowly Bacteria strain TA-11 (TA11NOD+) (NRRL B-18466) be especially described in US 5,021,076； In Appl.Environ.Microbiol.56,2399-2403,1990 and can be as Semen sojae atricolor liquid Body inoculum commercial (NP, BASF Corp., USA).Example as pesticide II The slow raw rhizobium strains of other Japan is described in US2012/0252672A.Other properly and especially exist Canada is commercial be bacterial strain 532c (The Nitragin Company, Milwaukee, Wisconsin, USA, from the land for growing field crops separator of Wisconsin；Nitragin bacterial strain preserving number 61A152；Can. J.Plant.Sci.70,661-666,1990) (such as RHIZOFLO, HISTICK, HICOAT Super, from Canada BASF Agricultural Specialties Ltd.).
The preferably slow raw root nodule bacteria of Japan, selected from bacterial strain TA-11 and 532c, more preferably use Japan to take root slowly The mixture of tumor bacteria strain TA-11 and 532c.
The slow raw rhizobium strains of other suitable and commercially available Japan (is such as shown in Appl.Environ. Microbiol.73 (8), 2635,2007) it is that SEMIA 566 (is separated also for 1966 by North America inoculum At 1966-1978 in Brazil's business inoculum), SEMIA 586 (=CB 1809；Initially exist Maryland, USA separate, but 1966 are obtained by Australia and connect for Brazil in 1977 Plant in body), CPAC 15 (=SEMIA 5079；From 1992 in business inoculum The natural mutation of SEMIA 566) and CPAC 7 (=SEMIA 5080；For business from 1992 The natural mutation of the SEMIA 586 in inoculum).These bacterial strains are especially suitable for being grown in Australia Or South America, the especially Semen sojae atricolor of Brazil.The slow raw root nodule bacteria SEMIA 5079 and SEMIA 5080 of Japan Mixture be particularly suitable.Some in above-mentioned bacterial strains are resorted to as novel species Erichsen the most raw root nodule bacteria (B. Elkanii), such as bacterial strain USDA 76 (Can.J.Microbiol.38,501-505,1992).
The slow raw rhizobium strains of another suitable and commercially available Japan is the E-109 (change of bacterial strain USDA 138 Kind, such as see Eur.J.Soil Biol.45,28-35,2009；Biol.Fertil.Soils 47, 81-89,2011；It is deposited in Agriculture Collection Laboratory of the Instituto de Microbiologia y Zoologia(IMYZA), Instituto Nacional deAgropecuaria (INTA), Castelar, Argentina).This bacterial strain is the suitableeest Conjunction is grown in South America, the most Argentine Semen sojae atricolor.
The slow raw rhizobium strains of another suitable and commercially available Japan be WB74 or WB74-1 (such as from Stimuplant CC, South Africa or SoyGro Bio-Fertilizer Ltd, South Africa).These bacterial strains are especially It is suitable for being grown in the Semen sojae atricolor in South America and Africa, especially South Africa.
The invention still further relates to following mixture, wherein this at least one pesticide II is taken root tumor slowly selected from Erichsen The most raw root nodule bacteria of bacterium and Liaoning, are more preferably selected from the most raw root nodule bacteria of Erichsen.These mixture are in Semen sojae atricolor It is particularly suitable for.The most raw root nodule bacteria of the most raw root nodule bacteria of Erichsen and Liaoning use culture medium known in the art and Fermentation technique such as cultivates about 5 days in yeast extract-mannitol meat soup (YEM) at 27 DEG C.
The invention still further relates to following mixture, wherein this at least one pesticide II is taken root tumor slowly selected from Erichsen The most raw root nodule bacteria of bacterium and Liaoning and further inclusion compound III, wherein compound III is selected from jasmone Acid or its salt or derivant, including LINL-OX, preferably methyl jasmonate or LINL-OX.
It is SEMIA 587 and SEMIA that suitable and commercially available Erichsen gives birth to rhizobium strains slowly 5019 (=29W) (for example, see Appl.Environ.Microbiol.73 (8), 2635,2007) and USDA 3254, USDA 76 and USDA 94.Preferably Erichsen gives birth to rhizobium strains SEMIA 587 slowly With the mixture of SEMIA 5019 be useful (such as GELFIX 5, from Brazil BASF Agricultural Specialties Ltd.).It is U-1301 that other commercially available Erichsens give birth to rhizobium strains slowly With U-1302 (such as from the product of Brazil Novozymes Bio As S.A. Optimize or the Semen sojae atricolor NITRASEC from Brazil LAGE y Cia).These bacterial strains are especially It is suitable for being grown in Australia or South America, the especially Semen sojae atricolor of Brazil.
The invention still further relates to following mixture, its Pesticides II is selected from Bradyrhizobium (Arachis), It should describe Semen vignae sinensis and mix cross inoculation group, the latter be especially included in Semen vignae sinensis (Vigna unguiculata), Big winged bean (Macroptilium atropurpureum), Phaseolus lunatus L. (Phaseolus lunatus) and Semen arachidis hypogaeae Intrinsic cowpea rhizobium on (Arachis hypogaea).Comprise Bradyrhizobium Arachis conduct This mixture of pesticide II be especially suitable for Semen arachidis hypogaeae, Semen vignae sinensis, Semen phaseoli radiati, moth bean, sand dune bean, Rice bean, snake gourd and Semen vignae sinensis of overgrowing, especially Semen arachidis hypogaeae.
The invention still further relates to following mixture, wherein this at least one pesticide II is selected from Bradyrhizobium (Arachis) and further inclusion compound III, wherein compound III selected from (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate or its salt or Derivant, including LINL-OX, preferably methyl jasmonate or LINL-OX.
Suitable and commercially available Bradyrhizobium (Arachis) bacterial strain be CB1015 (=IITA 1006, USDA 3446, general initially in India's collection；From Australian Inoculants Research Group；Such ashttp://www.qaseeds.com.au/inoculant_applic.php).Another is suitable Bacterial strain be Bradyrhizobium PNL01 (BASF Corp., USA；Bisson and Mason, On April 29th, 2010, project report, Worcester Polytechnic Institute, Worcester, MA, USA: http://www.wpi.edu/Pubs/E-project/Available/E-project-042810-163614/)。 These bacterial strains are especially suitable for being grown in Australia, North America or South America, the especially Semen arachidis hypogaeae of Brazil.
Especially to Semen vignae sinensis and Semen arachidis hypogaeae properly but also suitable and commercially available to Semen sojae atricolor Bradyrhizobium (Arachis) bacterial strain is Bradyrhizobium SEMIA 6144, SEMIA 6462 (=BR 3267) and SEMIA 6464 (=BR 3262；For example, see FEMS Microbiol.Letters 303 (2), 123-131,2010；Revista Brasileira de Ciencia do Solo 35 (3), 739-742,2011, ISSN 0100-0683)。
The invention still further relates to following mixture, wherein this at least one pesticide II fans Radix Sophorae Tonkinensis selected from late feathering Tumor bacterium (Bradyrhizobium sp. (Lupine)) (also referred to as B.lupini, B.lupines or lupin Root nodule bacteria (Rhizobium lupini)).This mixture is especially suitable for dry bean and lupin.
The invention still further relates to following mixture, wherein this at least one pesticide II fans Radix Sophorae Tonkinensis selected from late feathering Tumor bacterium (Lupine) (B.lupini) and comprise agricultural chemical compound II further, wherein compound III is selected from (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate or its salt or derivant, including LINL-OX, preferably methyl jasmonate or cis- Jasmone.
Suitable and commercially available late feathering fan bean rhizobium strains is that LL13 is (by the yellow plumage from France's soil Fan bean nodule separates；It is deposited in INRA, Dijon and Angers, France； http://agriculture.gouv.fr/IMG/pdf/ch20060216.pdf).This bacterial strain is especially suitable for growth In Australia, North America or Europe, the especially lupin in Europe.
Other suitable and commercially available late feathering fan bean rhizobium strains WU425 (at Esperance, Western Australia is separated by non-Australia leguminous plant Ornthopus compressus), WSM4024 (in the fact-finding process of 2005 by CRS by Australia lupin separate) and WSM471 (the Ornithopus pinnatus by Oyster Harbour, Western Australia Separate) such as it is described in Palta J.A., Berger J.B. and (edits), Proceed.12th International Lupin Conference, in JIUYUE, 2008 14-18 day, Fremantle, Western Australia, International Lupin Association, Canterbury, New Zealand, 47-50, ISBN 0-86476-153-8: Http:// www.lupins.org/pdf/conference/2008/Agronomy%20and%20Prod uc Tion/John%20Howieson%20and%20G%20OHara.pdf；Appl.Environ. Microbiol.71,7041-7052,2005；Australian J.Exp.Agricult.36 (1), 63-70, In 1996.
The invention still further relates to following mixture, wherein this at least one pesticide II is selected from middle raw rhizobium (meaning any middle raw rhizobium kind and/or bacterial strain), more preferably raw root nodule bacteria in chickpea (Mesorhizobium cicero).These mixture are the most suitable in Semen vignae sinensis.
The invention still further relates to following mixture, wherein this at least one pesticide II is selected from middle raw rhizobium And further inclusion compound III (component 3), wherein compound III selected from (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate or its salt or spreads out Biology, including LINL-OX, preferably methyl jasmonate or LINL-OX.
Raw root nodule bacteria in suitable and commercially available middle raw rhizobium bacterial strain for example, chickpea CC1192 (=UPM 848, CECT 5549；From Horticultural Research Station, Gosford, Australia；In Israel by chickpea (Cicer arietinum) nodule collection；Can.J. Microbiol.48,279-284,2002) and middle raw rhizobium strains WSM1271 (at Sardinia, Italy gathers, from plant host Biserrula pelecinus), WSM 1497 (at Mykonos, Greece gathers, from plant host Biserrula pelecinus), Mesorhizobium loti bacterial strain CC829 (long handle Radix Loti Corniculati (Lotus pedunculatus) and the L.ulginosus for Australia Business inoculum, is separated by L.ulginosus nodule at USA；NZP 2012), Radix Loti Corniculati root nodule Bacterium SU343 (the business inoculation for the tetraploid Radix Loti Corniculati (Lotus corniculatus) of Australia Body；Separate by host's nodule at USA).See, for example seeing Soil Biol.Biochem.36 (8), 1309-1317,2004；Plant and Soil 348 (1-2), 231-243,2011.Preferably Radix Loti Corniculati root Tumor bacteria strain is the Mesorhizobium loti CC829 being particularly useful for processing long handle Radix Loti Corniculati.
The invention still further relates to following mixture, wherein this at least one pesticide II is selected from Rhizobium of Milk Vetch (Mesorhizobium huakuii), also referred to as Rhizobium huakuii (is such as shown in Appl. Environ.Microbiol.77 (15), 5513-5516,2011).These mixture are particularly suitable for purple cloud (Astralagus) British, such as Astalagus sinicus (Herba Astragali Melilotoidis (Herba Astragali Sinici)), Thermopsis (Thermopsis), Such as Thermopsis luinoides (Goldenbanner) etc..
The invention still further relates to following mixture, wherein this at least one pesticide II is selected from Rhizobium of Milk Vetch And further inclusion compound III (component 3), wherein compound III selected from (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate or its salt or spreads out Biology, including LINL-OX, preferably methyl jasmonate or LINL-OX.
Suitable and commercially available Astragalus Nodules bacteria strain is separated by Herba Astragali Melilotoidis (Herba Astragali Sinici) in the rice field in south China HN3015 (is such as shown in World J.Microbiol.Biotechn.23 (6), 845-851,2007, ISSN 0959-3993)。
The invention still further relates to following mixture, wherein this at least one pesticide II is selected from agalactia azospirillum, Azospirillum brasilense, raw fat azospirillum, Irakense and high salt azospirillum, more preferably Selected from Azospirillum brasilense, it is especially selected from Azospirillum brasilense bacterial strain BR 11005 (Sp245) and AZ39, The latter two are all commercially used for Brazil and can be by EMBRAPA-Agribiologia, and Brazil obtains. These mixture are the most suitable in Semen sojae atricolor.
The invention still further relates to following mixture, wherein this at least one pesticide II is selected from agalactia azospirillum, Azospirillum brasilense, raw fat azospirillum, Irakense and high salt azospirillum, more preferably Azospirillum brasilense, and comprise pesticide III further, its Pesticides III selected from (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate or its Salt or derivant, including LINL-OX, preferably methyl jasmonate or LINL-OX.
The invention still further relates to following mixture, wherein this at least one pesticide II is selected from rhizobium leguminosarum dish Bean biotype, especially its bacterial strain RG-B10；Rhizobium leguminosarum Herba Trifolii Pratentis biotype, especially its Bacterial strain RP113-7, R.l.bv.viciae, especially its bacterial strain SU303, WSM1455 and P1NP3Cst；R.tropici, especially its bacterial strain CC511, SEMIA 4077 and SEMIA 4080； And Sinorhizobium meliloti, especially its bacterial strain MSDJ0848.
According to another embodiment, at inventive mixture Pesticides II selected from a kind of selected from following change Compound II:Sinorhizobium meliloti MSDJ0848, S.meliloti NRG185, S.meliloti RRI128, S.meliloti SU277, rhizobium leguminosarum Kidney bean biotype RG-B10, R. Leguminosarum bv.viciae P1NP3Cst, R.l.bv.viciae RG-P2, R.l.bv.viciae SU303, R.l.bv.viciae WSM1455, rhizobium leguminosarum Herba Trifolii Pratentis biotype RP113-7, pea Bean root nodule bacteria Herba Trifolii Pratentis biotype 095, rhizobium leguminosarum Herba Trifolii Pratentis biotype TA1, rhizobium leguminosarum Herba Trifolii Pratentis biotype CC283b, rhizobium leguminosarum Herba Trifolii Pratentis biotype CB782, rhizobium leguminosarum three Leaf grass biotype CC1099, rhizobium leguminosarum Herba Trifolii Pratentis biotype CC275e, rhizobium leguminosarum SANYE Grass biotype WSM1325, R.tropici CC511, R.tropici SEMIA 4077 and R.tropici SEMIA 4080。
Sinorhizobium meliloti can be by BASF Corp., and USA is as product Alfalfa&Luzerne is commercial.Rhizobium leguminosarum Kidney bean biotype can be by BASF Corp., USA Commercial as product RhizoStick.These bacterial strains be particularly suitable as various leguminous plant such as Herba Medicaginis, The inoculum of Herba Trifolii Pratentis, Semen Pisi sativi, Kidney bean, Radix Crotalariae szemoensis, Semen sojae atricolor, Semen arachidis hypogaeae etc..
Also referred to as R.phaseoli and the nearest Semen Pisi sativi root that type I separator is re-classified as R.etli Tumor bacterium Kidney bean biotype can be by BASF Corp., USA as the product RhizoStick for dry bean Commercial.Especially to leguminous plant common kidney bean (Phaseolus vulgaris), but also to other crops as beautiful Rice and the specially suitable bacterial strain of Caulis et Folium Lactucae sativae are as follows: rhizobium leguminosarum Kidney bean biotype RG-B10 (is equal to bacterium Strain USDA 9041) in Africa as NODULATOR Dry Bean, in the U.S. as HiStick NT Dry bean and in Canada as NOUDLATOR Dry Bean by BASF Corp., USA or Canada BASF Agricultural Specialties Ltd. is commercial and by Int.J.Syst. Bacteriol.46 (1), 240-244,1996；Int.J.Syst.Evol.Microbiol.50,159-170, 2000 is known.
Other rhizobium leguminosarum Kidney bean biotypes or R.etli bacterial strain are such as by above-mentioned list of references and Appl. Environ.Microbiol.45 (3), 737-742,1983；Ibida 54 (5), 1280-1283,1988 Known.
R.l.bv.viciae P1NP3Cst (also referred to as 1435) by New Phytol.179 (1), 224-235, 2008 is known；And such as at the NODULATOR PL Peat from BASF Corp., USA In Granule；Or from Canada BASF Agricultural Specialties Ltd.'s In NODULATOR XL PL.R.l.bv.viciae RG-P2 (also referred to as P2) is in Canada's conduct Semen Pisi sativi and Radix Crotalariae szemoensis inoculum with the RhizUP peat composed of rotten mosses by Canada BASF Agricultural Specialties Ltd. is commercial.R.l.bv.viciae WSM1455 is as Semen Viciae fabae The NODULAID peat composed of rotten mosses is commercial by Australia BASF Agricultural Specialties Pty Ltd. R.l.bv.viciae SU303 is as NODULAID Group E, the NODULAID for Semen Pisi sativi The NT peat composed of rotten mosses or NODULATOR granule are by Australia BASF Agricultural Specialties Pty Ltd is commercial.R.l.bv.viciae WSM1455 is as the NODULAID for Semen Viciae fabae The Group F peat composed of rotten mosses, NODULAID NT and NODULATOR granule are by Australia BASF Agricultural Specialties Pty Ltd commercial and Canada also serve as Semen Viciae fabae inoculum with NODULATOR SA Semen Viciae fabae or in Europe with Faba Sterile Peat or Canada with NODULATOR Semen Viciae fabae granule is by BASF Agricultural Specialties Ltd. city of Canada Purchase.
Rhizobium leguminosarum Herba Trifolii Pratentis biotype by BASF Corp., USA as product Nodulator Or DORMAL true clover is commercial.It is particularly useful for the trefoil Suitable strains of all kinds such as Under: purchased from BASF Corp., USA rhizobium leguminosarum Herba Trifolii Pratentis biotype strains RP113-7 (also It is referred to as 113-7) and 095；Also Appl.Environ.Microbiol.44 (5), 1096-1101 are seen.By The Suitable strains rhizobium leguminosarum Herba Trifolii Pratentis biotype TA1 that Australia obtains is by Appl.Environ. Microbiol.49 (1), 127-131,1985 are known and as the NODULAID for butch clover The peat composed of rotten mosses is commercial by Australia BASF Agricultural Specialties Pty Ltd.Rhizobium leguminosarum Herba Trifolii Pratentis biotype CC283b is big by Australia as the NODULAID peat composed of rotten mosses for Caucasian clover BASF Agricultural Specialties Pty Ltd is commercial for Leah.Rhizobium leguminosarum Herba Trifolii Pratentis is biological Type CC1099 as sainfoin the NODULAID peat composed of rotten mosses by Australia BASF Agricultural Specialties Pty Ltd is commercial.Rhizobium leguminosarum Herba Trifolii Pratentis biotype CC275e As the NODULAID peat composed of rotten mosses for NZ butch clover by Australia BASF Agricultural Specialties Pty Ltd is commercial.Rhizobium leguminosarum Herba Trifolii Pratentis biotype CB782 is as Kenny The NODULAID peat composed of rotten mosses of sub-butch clover is by Australia BASF Agricultural Specialties Pty Ltd is commercial.Rhizobium leguminosarum Herba Trifolii Pratentis biotype strains WSM1325 in 1993 by Greece Serifos island is collected, for the trefoil NODULAID peat composed of rotten mosses with for trefoil NODULATOR granule is by Australia BASF Agricultural Specialties Pty Ltd Commercial, for the annual Mediterranean Herba Trifolii Pratentis of wide scope, and by Stand.Genomic Sci. 2 (3), 347-356,2010 are known.Rhizobium leguminosarum Herba Trifolii Pratentis biotype strains WSM2304 is crow Gui is drawn to separate and by Stand.Genomic Sci. by Trifolium polymorphum in 1998 2 (1), 66-76,2010 are it is known that be particularly suitable for making its Herba Trifolii Pratentis host take root tumor in Uruguay.
R.tropici may be used for especially at tropical area such as the legume of Brazil.It is particularly useful for The trefoil Suitable strains of all kinds is as follows: R.tropici bacterial strain SEMIA 4080 (is equal to PRF 81；By Soil Biology&Biochemistry 39,867-876,2007；BMC Microbiol.12, 84,2012 is known) for the NITRAFIX of Kidney beanThe peat composed of rotten mosses is by Brazil BASF Agricultural Specialties Ltd. is commercial and connects as business in Brazil from 1998 Plant body and be used for common kidney bean crop, be preserved inEstadual de Pesquisa Agropecu á ria, Rua570, Bairro Menino Deus, Porto Alegre/RS, Brazil.R.tropici may be used for especially at tropical area such as the pulse family of Brazil Crop.It is particularly useful for the trefoil Suitable strains of all kinds as follows: R.tropici bacterial strain SEMIA 4077 (is equal to CIAT899；Rev.Agron.44 (4) Fortaleza, 2013 Year 10/12 month) for the NITRAFIX of Kidney beanThe peat composed of rotten mosses is by Brazil BASF Agricultural Specialties Ltd. is commercial.R.tropici bacterial strain CC511 is for common kidney bean The NODULAID peat composed of rotten mosses by Australia BASF Agricultural Specialties Pty Ltd city Purchase and known by Agronomy, N.Z.36,4-35,2006.
The invention still further relates to following mixture, wherein this at least one pesticide II is selected from rhizobium leguminosarum dish Bean biotype, rhizobium leguminosarum Herba Trifolii Pratentis biotype, R.l.bv.viciae, R.tropici and Sinorhizobium meliloti, and inclusion compound III further, wherein compound III is selected from (1S,2S)-3-oxo-2-(2'-cis-pentenyl)cyclopentan-1-acetate or its salt or derivant, including LINL-OX, preferably methyl jasmonate or cis- Jasmone.
According to another embodiment, this at least one pesticide II is selected from acide eating Darfot bacteria, especially Bacterial strain RAY209, especially in Semen sojae atricolor and Corolla (Canola).
According to another embodiment, this at least one pesticide II is selected from molten Bacillus (Lysobacter), It is preferably selected from the molten bacillus of antibiotic, especially bacterial strain 13-1 and HS124, preferably uses in rice or Fructus Piperis In preventing and treating Phytophthora or Bacterial Leaf Blight.According to another embodiment, this at least one pesticide II selects Self-produced mould molten bacillus, especially bacterial strain 3.1T8.
According to another embodiment, this at least one pesticide II is selected from Rhodopseudomonas, is preferably selected from P.chloraphis MA 342 and Rhodopseudomonas DSM 13134.
According to another embodiment, this at least one pesticide II is selected from ratio Lay penicillium sp.
Further preferably comprising selected from L6) biological pesticide organized is as the mixture of pesticide II (component 2), this group Biological pesticide be preferably selected from abscisic acid, aluminium silicate (Kaolin), humic acid esters, yellow tang (Norway Sargassum, Brown algae)) extract and brown seaweed (Sargassum) extract.
Further preferably comprise selected from isoflavone element, formononetin, hesperetin and the biological pesticide of naringenin Mixture as pesticide II.
Therefore, the present invention additionally relates to comprise a kind of compound I (component 1) and a kind of pesticide II (component 2) compositions, its Pesticides II is selected from " Co.2 " hurdle of C-1 to the C-837 row of table C.
Another embodiment relates to listed compositions C-1 to C-837, wherein a line of table C in table C In each case corresponding to comprising one of the compound of formula I enumerated in this specification (component 1) and described Described in row selected from A)-O) the corresponding pesticide II (component 2) that organizes combines as the antifungal of active component Thing.The most described compositions comprises active component with Synergistic effective dose.
Table C:Comprise the one as active component and enumerate compound I (I) (in Co.1 hurdle) and as component 2) one (in Co.2 hurdle) is selected from A)-O) [it is for nitrile Fluoxastrobin as defined above for the pesticide organized Such as be encoded to (A.1.1)] compositions
It is known for being referred to as the active substance of component 2, its preparation and such as activity to harmful fungoid thereof (seeing http://www.alanwood.net/pesticides/)；These materials can be commercial.By IUPAC Compound, its preparation and pesticide activity thereof that nomenclature describes also are known (to see Can.J.Plant Sci.48 (6), 587-94,1968；EP-A 141 317；EP-A 152 031；EP-A 226 917； EP-A 243 970；EP-A 256 503；EP-A 428 941；EP-A 532 022；EP-A 1 028 125；EP-A 1 035 122；EP-A 1 201 648；EP-A 1 122 244, JP 2002316902；DE 19650197；DE 10021412；DE 102005009458；US 3,296,272； US 3,325,503；WO 98/46608；WO 99/14187；WO 99/24413；WO 99/27783； WO 00/29404；WO 00/46148；WO 00/65913；WO 01/54501；WO 01/56358； WO 02/22583；WO 02/40431；WO 03/10149；WO 03/11853；WO 03/14103； WO 03/16286；WO 03/53145；WO 03/61388；WO 03/66609；WO 03/74491； WO 04/49804；WO 04/83193；WO 05/120234；WO 05/123689； WO 05/123690；WO 05/63721；WO 05/87772；WO 05/87773；WO 06/15866； WO 06/87325；WO 06/87343；WO 07/82098；WO 07/90624, WO 11/028657, WO 2012/168188, WO 2007/006670, WO 2011/77514；WO13/047749, WO 10/069882, WO 13/047441, WO 03/16303, WO 09/90181, WO 13/007767, WO 13/010862, WO 13/127704, WO 13/024009, WO 13/024010 With WO 2013/047441).
The mixture of active substance can pass through conventional method, such as by the compositions to compound I Be prepared as in addition to active component also comprising the combination of at least one inert fraction (auxiliary agent) to method Thing.
About the conventional ingredient of this based composition, with reference to being given explanation to the compositions containing compound I.
The mixture of active substance of the present invention is suitable as antifungal, as compound of formula I. They are characterised by the plant pathogenic fungi to wide scope, especially selected from Ascomycetes, load Gammaproteobacteria, deuteromycetes (Deuteromycetes) and Peronosporomycetes's (synonym Oomycete) Plant pathogenic fungi has significant effect.Additionally, respectively with reference to having related compounds and containing chemical combination The explanation of the Fungicidally active of the compositions of thing I.
According to an embodiment, selected from L1), L3) and L5) microbial pesticide organized not only include this The pure culture of the separation of the defined corresponding microorganism of literary composition, and include its cell-free extract, its Suspension in full broth culture or as the culture medium containing metabolite or by microorganism or microorganism The purification metabolite that the full broth culture of bacterial strain obtains.
According to another embodiment, selected from L1), L3) and L5) microbial pesticide organized not only include this The pure culture of the separation of the defined corresponding microorganism of literary composition, and include its cell-free extract or extremely Few its metabolite a kind of and/or have all its identify feature corresponding microorganism mutant and should The cell-free extract of mutant or at least one metabolite.
" full culture broth " used herein refers to containing the trophocyte suspended in the medium and/or spore The microorganism of son and the liquid culture of the optional metabolite produced by corresponding microorganism.
" culture medium " used herein refers to can be by training in described culture medium, preferred liquid meat soup Support microorganism and obtain and the remaining culture medium when removing the cell of growth in this culture medium, such as By being centrifuged, filter, settle or other modes well-known in the art removing in liquid gravy Remaining supernatant during the cell grown；Such as comprise and produced by corresponding microorganism or be secreted into culture medium In metabolite.Otherwise referred to as " culture medium " of " supernatant " such as can be by about 2-30 DEG C At a temperature of (more preferably at a temperature of 4-20 DEG C) at about 5,000-20,000 × g (more preferably from about 15,000 × g) under centrifugal about 10-60min (more preferably from about 15-30min) and obtain.
" cell-free extract " used herein refers to plant cell, the extract of spore and/or microorganism Full culture broth, it comprises the cell metabolite produced by corresponding microorganism and can pass through this area Known method of cell disruption such as solvent basal cell breaking method (such as organic solvent such as alcohols, sometimes with Suitably salt combination), temperature basal cell's breaking method, apply shearing force, use the thin of ultrasonic generator Born of the same parents are broken to be obtained.Required extract such as can be dried by Conventional concentration technology, evaporate, be centrifuged etc. dense Contracting.The most before the use crude extract can also be applied some and use organic solvent and/or water base Jie The washing step of matter.
Terms used herein " metabolite " refers to by microorganism (such as fungus and antibacterial, the especially present invention Bacterial strain) any component of producing, compound, material or by-product (include but not limited to that little molecule is secondary Metabolite, polyketide, fatty acid synthetase product, non-ribosomal peptides, ribosome peptide, albumen Matter and enzyme), it has any beneficial effect such as pesticide activity as herein described or improves plant growing, plants The water-use efficiency of thing, plant health, plant outward appearance or useful in soil around vegetable active herein The population of microorganism.
" separator " used herein refers to the pure culture of microorganism separated by its natural origin, this point Obtain by cultivating single microorganism colony from thing.Separator is that to be derived from the allos of microorganism wild The pure culture of population.
" bacterial strain " used herein refers to present and belongs to mutually syngenesious phenotype and/or yielding characteristics (with phase Those of other separators of sibling species or bacterial strain are different) separator or separator group.
Term " mutant " refers to the microorganism obtained by direct mutagenesis selection, but also includes Mutation or the microorganism of regulation in other respects (such as via introducing plasmid) further.Therefore, real The scheme of executing includes the mutant of corresponding microorganism, variant and/or derivant, including naturally-produced and artificial Both induced mutants.Such as, mutant can make this microorganism stand by using conventional method Know derivant, induce such as N-methyl nitrosoguanidine.
Comprising selected from L1), L3) and L5) in the case of the mixture of microbial pesticide II organized, this Bright microorganism used therefor in batches or can repeat not feed batch processes continuously or not with batch processes or with charging Cultivate continuously.The summary of known cultural method can be at the textbook (Bioprozesstechnik of Chmiel 1.Einf ü hrung in die Bioverfahrenstechnik (Gustav Fischer Verlag, Stuttgart, 1991)) or textbook (the Bioreaktoren und periphere of Storhas Einrichtungen (Vieweg Verlag, Braunschweig/Wiesbaden, 1994)) in find.
Work as living microorganism, as selected from L1), L3) and L5) the pesticide II that organizes, form these compositionss A part of time, this based composition can pass through conventional method (for example, see H.D.Burges: Formulation of Micobial Biopestcides, Springer, 1998) as except active component Prepared by the compositions comprising outward at least one auxiliary agent (inert fraction).The suitable conventional class of this based composition Type is suspension, powder, powder, paste, granule, mould, capsule and mixture thereof.Compositions The example of type is suspension (such as SC, OD, FS), capsule (such as CS, ZC), sticks with paste, lozenge, Wettable powder or powder (such as WP, SP, WS, DP, DS), mould (such as BR, TB, DT), granule (such as WG, SG, GR, FG, GG, MG), insect killing product (such as LN) with And process the gel formulation (such as GF) of plant propagation material such as seed.Herein it has to be considered that The selection of each preparaton type or auxiliary agent should not affect during said composition stores and ought finally use The vigor of this microorganism when soil, plant or plant propagation material.Suitably preparaton such as exists WO 2008/002371, US 6955,912, US 5,422, mentions in 107.
The example of suitable auxiliary agents is those the most previously mentioned, and wherein care must be taken that this analog assistant Selection and amount should not affect the vigor of microbial pesticide in said composition.Particularly with antibacterial and molten Agent, it is necessary to consider the compatibility of corresponding microorganism pesticide and corresponding microorganism.Additionally, the agriculture Han microorganism The compositions of medicine can contain stabilizer or nutrient and UV protective agent further.Suitably stabilizer Or nutrient for example, alpha-tocopherol, trehalose, glutamate, Glu, potassium sorbate, various saccharides such as Portugal Grape sugar, sucrose, lactose and maltodextrin (H.D.Burges:Formulation of Micobial Biopestcides, Springer, 1998).Suitably UV protective agent for example, inorganic compound such as two Titanium oxide, zinc oxide and iron oxide pigment or organic compound such as benzophenone, benzotriazole and Phenyl triazines.These compositionss are except the auxiliary agent being previously mentioned the compositions of inclusion compound I herein Optionally comprise 0.1-80% stabilizer or nutrient and 0.1-10%UV protective agent outward.
When being used in crop protection by the mixture comprising microbial pesticide, rate of application is preferably from about 1×106-5×1015(or bigger) CFU/ha.Preferably spore concentration is about 1 × 107-1×1011CFU/ha。 In the case of (entomopathogenicity) nematicide is as microbial pesticide (such as Si Shi noctuid nematicide), rate of application It is preferably from about 1 × 105-1×1012(or bigger), more preferably 1 × 108-1×1011, even more preferably 5×108-1×1010Individuality (such as ovum, larva or any other life phase form, preferably infectiousness Larval stage)/ha.
When the mixture comprising microbial pesticide is used for seed treatment, for plant propagation material Rate of application is preferably from about 1 × 106-1×1012(or bigger) CFU/ seed.Preferred concentration is about 1×106-1×1011CFU/ seed.In the case of microbial pesticide II, for plant propagation material Rate of application is it is also preferred that about 1 × 107-1×1014(or bigger) CFU/100kg seed, preferably 1 × 109To about 1×1011CFU/100kg seed.
I. synthetic example
Embodiment 1
Step 1a synthesis 1-(4-bromo-2-chlorphenyl)-2-chloroethene ketone
To 2-chloro-4-bromoacetophenone (500g), MeOH (137g) at CH2Cl2(4L) in the mixture in Dropping SO2Cl2(578g, at 1L CH2Cl2In), maintain internal temperature less than 30 DEG C.Wave at gas Sending out after stopping, HPLC shows and converts completely.It is carefully added into H2O (3L) also uses 50%NaOH Regulation pH to 6.5.Separate each phase and by aqueous phase CH2Cl2Extraction (2 × 1L).Organic by merge With saline washing and at Na2SO4Upper dry.Crude product obtains and without entering one with toughening oil (608g) Step purifies and uses.HPLC:tR=3.096min；1H-NMR (300MHz, CDCl3): δ=4.65 (2H), 7.40-7.65(3H)。
Step 1b synthesis 2-(4-bromo-2-chlorphenyl)-1-chlorine amyl-3-alkynes-2-alcohol
At-20 DEG C, by 1-(4-bromo-2-chlorphenyl), (267g, at 500mL CH for-2-chloroethene ketone solution2Cl2 In) be added dropwise in acrylate-1-alkynyl magnesium bromide (1915mL 0.5M THF solution) and warm to room temperature.Will Reactant mixture adds saturated NH4In Cl aqueous solution (5L) and use CH2Cl2Extraction (3 × 2L).To close And organic phases washed with brine, at Na2SO4Above it is dried and evaporates.Crude product do not have any enter one Step purifies and is used in next reaction.HPLC:tR=3.271min；1H-NMR (300MHz, CDCl3): δ=1.85 (3H), 3.95 (1H), 4.20 (1H), 7.45 (1H), 7.55 (1H), 7.80 (1H).
Step 1c 2-(4-bromo-2-chlorphenyl)-1-(1,2,4-triazol-1-yl) amyl-3-alkynes-2-alcohol
By 2-(4-bromo-2-chlorphenyl)-1-chlorine amyl-3-alkynes-2-alcohol (305g), 1,2,4-triazole at 100 DEG C (191g) stir 30 minutes in NMP (2L) with NaOH (83.2g).HPLC shows and converts completely. Reactant mixture is used saturated NH4Cl aqueous solution (2L) dilution also extracts (4 × 2L) with MTBE.To close And organic extract liquid with saline (1L) washing and at Na2SO4Upper dry.By iPr after evaporation2O ties Crystalline substance, obtains target compound (322.6g) with clear crystal.HPLC:tR=2.629min；1H-NMR (300MHz, CDCl3): δ=1.80 (3H), 4.70 (1H), 4.90 (1H), 7.40 (1H), 7.60 (1H), 7.75 (1H), 7.90 (1H), 8.10 (1H).
Embodiment 2:
Step 2a synthesis (4-bromo-2-chlorphenyl) cyclopropyl ketone
Bromo-for the 4-2-chloro-1-iodobenzene (250g) solution in 0.5L THF is cooled to-20 DEG C and adds IPrMgCl solution (780mL, 1.3eq), keeps reaction temperature to be-20 DEG C.Display is controlled at HPLC After converting completely, under somewhat cooling, in 25-35 DEG C, grignard solution is transferred to cyclopropanecarbonyl chloride (107g)、AlCl3(3.2g), LiCl (2.0g) and the CuCl (2.34g) previously prepared mixing in 1L THF In thing.After HPLC shows and converts completely, reactant mixture is added saturated NH4Cl aqueous solution (1L) in.After with MTBE extraction (3 × 1L), the organic facies saline (500mL) merged is washed And at Na2SO4Upper dry.After removal of solvent under reduced pressure, target mixture is separated and without entering one Step purifies and is used in next reaction.1H-NMR (300MHz, CDCl3): δ=0.8-1.2 (4H), 2.40 (1H), 7.25-7.60 (3H).
Step 2b synthesis 2-(4-bromo-2-chlorphenyl)-2-cyclopropyl rings oxidative ethane
Several are at room temperature divided to add in the KOtBu (90.4g) suspension in DMSO (800mL) Me3SI(195g).(4-bromo-2-chlorphenyl) cyclopropyl ketone (220g) is added molten after stirring 1 hour Liquid.After 48 hours reactant mixture added in water (3L) and extract (3 × 1L) with EtOAc. By organic facies saline (1L) washing merged and at Na2SO4Upper dry.Removal of solvent under reduced pressure is marked Topic compound, it is used in next step without purifying further.1H-NMR (300MHz, CDCl3): δ=0.4-1.2 (5H), 2.8 (1H), 3.00 (1H), 7.20-7.65 (3H).
Step 2c synthesis 1-(4-bromo-2-chlorphenyl)-1-cyclopropyl-2-(1,2,4-triazol-1-yl) ethanol
By the thick 2-in NMP (1L) (4-bromo-2-chlorphenyl)-2-cyclopropyl rings oxidative ethane (211g), NaOH (62g) and 1,2,4-triazole (213g) are heated to 120 DEG C and keep 1 hour.HPLC has shown Full conversion.Reactant mixture is added saturated NH4(3 × 1L) is extracted in Cl solution (1L) and with MTBE. By the organic phases washed with brine merged and at Na2SO4Upper dry.Will be thick after removal of solvent under reduced pressure Product is by iPr2O crystallizes, and obtains product (108g) with pale solid.1H-NMR (300MHz, CDCl3): δ=0.2 (1H), 0.4 (2H), 0.6 (1H), 2.75 (1H), 4.55 (2H), 5.35 (1H), 7.25 (1H), 7.50 (2H), 7.85 (1H), 8.00 (1H).
Step 2d synthesis 1-[the chloro-4-of 2-(2-cyclopropyl acethlene base) phenyl]-1-cyclopropyl-2-(1,2,4-triazol-1-yl) Ethanol
By 1-(4-bromo-2-chlorphenyl)-1-cyclopropyl-2-(1,2,4-triazol-1-yl) ethanol (1.00g), cyclopropyl Acetylene (350mg), Pd (dppf) Cl2(21.0mg), CuI (50.0mg) and NEt3(320mg) mixing Thing is heated to backflow in MeCN (5mL) and keeps 12 hours.HPLC shows and converts completely.Will Reactant mixture is poured in saline and extracts (3 × 10mL) with MeCN.By the organic facies of merging at Silicon stone Filter and removal of solvent under reduced pressure on post.By being purified residue by column chromatography, obtain with solid (120mg) Product.HPLC-MS (MSD5): tR=1.054 [M=328 [M+]]；1H-NMR (500MHz, CDCl3): δ=0.10-0.90 (8H), 1.40 (1H), 1.80 (1H), 4.60 (1H), 5.40 (1H), 7.10-7.50 (3H), 7.85 (1H), 8.10 (1H).
Suitably change initial compounds, use program shown in synthetic example to obtain other compounds I, Especially triazole compounds I.A1a, wherein A is N and Z is cyclopropyl.Gained compound and physics Data are listed in the table below in I together.
Table I
*: HPLC method data:
Mobile phase: A: water+0.1%TFA；B: acetonitrile；Gradient: 5%B to 100% in 1.5 minutes B；Temperature: 60 DEG C；MS method: ESI positivity；Quality region (m/z): 100-700；Flow velocity: 0.8ml/min to 1.0ml/min in 1.5 minutes；Post: Kinetex XB C18 1.7 μ 50 × 2.1mm； Equipment: Shimadzu Nexera LC-30LCMS-2020.
II. the acting embodiment to harmful fungoid
The fungicidal action of compound of formula I is confirmed by following test:
Microtest
By molten for deposit that reactive compound separately formulated one-tenth concentration in dimethyl sulfoxide is 10000ppm Liquid.
M1 is activity (Botrci) to gray mold Botrytis cinerea in titer plate is tested
Stock solution is mixed according to ratio, moves on in titer plate (MTP) and dilute with water with pipet Release to described concentration.It is subsequently adding Botrytis cinerea at biological Fructus Hordei Germinatus or yeast-bacteria peptone-sodium acetate Spore suspension in aqueous solution.Each plate is placed in the steam-laden room that temperature is 18 DEG C.Connect Absorption spectrophotometry is used to measure MTP under 405nm after planting 7 days.Compound I-1, I-2 and I-3 The growth of 0% is demonstrated respectively under 31ppm.
M2 is activity (Pyrior) to rice blast Pyricularia oryzae in titer plate is tested
Stock solution is mixed according to ratio, moves on in titer plate (MTP) and dilute with water with pipet Release to described concentration.It is subsequently adding Pyricularia oryzae at biological Fructus Hordei Germinatus or yeast-bacteria peptone-glycerol liquor Spore suspension in solution.Each plate is placed in the steam-laden room that temperature is 18 DEG C.Inoculation 7 Absorption spectrophotometry is used to measure MTP under 405nm after it.Compound I-1, I-2 and I-3 are at 31ppm Lower demonstrate respectively 0% growth.
M3 activity (Septtr) to the leaf spot caused by wheat septoria on Semen Tritici aestivi
Stock solution is mixed according to ratio, moves on in titer plate (MTP) and dilute with water with pipet Release to described concentration.It is subsequently adding wheat septoria at biological Fructus Hordei Germinatus or yeast-bacteria peptone-glycerol Spore suspension in aqueous solution.Each plate is placed in the steam-laden room that temperature is 18 DEG C.Connect Absorption spectrophotometry is used to measure MTP under 405nm after planting 7 days.Compound I-1, I-2 and I-3 exist The growth of 0% is demonstrated respectively under 31ppm.
By the growth (100%) of parameter and the scheme that compares without reactive compound measured and do not contain Fungus compares with the blank value of reactive compound, to determine pathogen phase in each reactive compound To growth percent.

Claims (15)

1. compound of formula I and N-oxide thereof and can agricultural salt:
Wherein
A is CH or N；
R1For C1-C6Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C3-C6Cycloalkyl；
Wherein R1Aliphatic moiety be not further substituted or can with 1,2,3 or at most maximum Can number be independently selected from following identical or different group R1a:
R1aHalogen, OH, CN, C1-C4Alkoxyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl And C1-C4Halogenated alkoxy；
Wherein R1Cyclic alkyl moiety be not further substituted or with 1,2,3,4,5 or extremely The most the maximum number of it is independently selected from following identical or different group R1b:
R1bHalogen, OH, CN, C1-C4Alkyl, C1-C4Alkoxyl, C1-C4Haloalkyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl and C1-C4Halogenated alkoxy；
R2For hydrogen, C1-C4Alkyl, C2-C4Alkenyl, C2-C4Alkynyl；
Wherein R2Aliphatic moiety be not further substituted or can with 1,2,3 or at most maximum Can number be independently selected from following identical or different group R2a:
R2aHalogen, OH, CN, C1-C4Alkoxyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl And C1-C4Halogenated alkoxy；
R3Selected from hydrogen, halogen, CN, C1-C4Alkyl, C1-C4Alkoxyl, C2-C4Alkenyl, C2-C4 Alkynyl, C3-C6Cycloalkyl, S (O)p(C1-C4Alkyl), wherein R3The most unsubstituted or quilt 1,2,3 or 4 R3aIt is further substituted with；Wherein
R3aIndependently selected from halogen, CN, OH, C1-C4Alkyl, C1-C4Haloalkyl, C3-C6Ring Alkyl, C3-C6Halogenated cycloalkyl, C1-C4Alkoxyl and C1-C4Halogenated alkoxy；
Z is C3-C8Cycloalkyl or C3-C8Cycloalkenyl group, wherein cycloalkyl or cycloalkenyl group unsubstituted (m=0) or By (R4)mReplace；Wherein
M is 0,1,2,3 or 4；With
R4In each case independently selected from halogen, CN, NO2、OH、SH、C1-C6Alkyl, C1-C6Alkoxyl, C2-C6Alkenyl, C2-C6Alkynyl, C3-C6Cycloalkyl, C3-C6Cycloalkanes Epoxide, S (O)p(C1-C4Alkyl), C (=O) (C1-C4Alkyl), C (=O) (OH), C (=O) (O-C1-C4Alkyl), C (=O) (NH (C1-C4Alkyl)), C (=O) (N (C1-C4Alkane Base)2)；Wherein R4The most unsubstituted or by 1,2,3 or 4 R4aIt is further substituted with, Wherein
R4aIndependently selected from halogen, CN, NO2、OH、C1-C4Alkyl, C1-C4Haloalkyl, C3-C6Cycloalkyl, C3-C6Halogenated cycloalkyl, C1-C4Alkoxyl and C1-C4Haloalkoxy Base；
P is 0,1 or 2.
Compound the most according to claim 1, wherein A is N.
3., according to the compound of claim 1 or 2, wherein Z is unsubstituted or such as claim 1 Defined in the C that is replaced like that3-C8Cycloalkyl.
Compound the most as claimed in one of claims 1-3, wherein Z is unsubstituted or such as right Require the C being replaced like that defined in 13-C8Cycloalkenyl group.
Compound the most as claimed in one of claims 1-4, wherein m is 0.
Compound the most as claimed in one of claims 1-4, wherein m is 1,2 or 3.
Compound the most as claimed in one of claims 1-6, wherein R3For hydrogen.
Compound the most as claimed in one of claims 1-6, wherein R3For F, Cl, Br, CN, C1-C4Alkyl, C1-C4Haloalkyl, C1-C4Alkoxyl or S (C1-C4Alkyl).
Compound the most as claimed in one of claims 1-8, wherein R2For hydrogen.
Following compounds I-1 to I-30 the most according to claim 1, wherein A is N, R2For hydrogen And respectively, R1For cyclopropyl, R3It is 0 and Z to be cyclopropyl (I-1) for Cl, m；R1For CH3, R3It is 0 and Z to be cyclopropyl (I-2) for Cl, m；R1For C ≡ C-CH3, R3For Cl, M is 0 and Z to be C3H5(cyclopropyl) (I-3)；R1For C3H5(cyclopropyl), R3For Cl and Z-(R4)m For 1-OH-cyclopenta (I-4)；R1For C3H5(cyclopropyl), R3It is 0 and Z to be 1-ring for Cl, m Octenyl (I-5)；R1For C3H5(cyclopropyl), R3It is 0 and Z to be ring octyl group (I-6) for Cl, m； R1For C3H5(cyclopropyl), R3It is 0 and Z to be cyclopenta (I-7) for Cl, m；R1For C (CH3)3, R3For H, Z-(R4)mFor 1-OH-cyclopenta (I-8)；R1For C (CH3)3, R3For H；M is 0 And Z is 1-cyclo-octene base (I-9)；R1For C (CH3)3；R3For H；M is 0 and Z to be ring octyl group (I-10)；R1For C (CH3)3；R3For H and Z-(R4)mFor 1-OCH3-cyclohexyl (I-11)；R1For C(CH3)3, R3It is 0 and Z to be cyclopenta (I-12) for H, m；R1For CH3, R3For CF3, M is 0 and Z to be ring octyl group (I-13)；R1For CH3；R3For CF3And Z-(R4)mFor 1-OH-ring Amyl group (I-14)；R1For CH3, R3For CF3And Z-(R4)mFor 1-OCH3-cyclohexyl (I-15)；R1 For CH3, R3For CF3, m is 0 and Z to be cyclopenta (I-16)；R1For C3H5(cyclopropyl), R3 For CF3, m is 0 and Z to be C3H5(cyclopropyl) (I-17)；R1For CH=CH (CH3), R3For Cl, m are 0 and Z to be C3H5(cyclopropyl) (I-18)；R1For C ≡ C-CH3, R3For CF3, m It is 0 and Z to be C3H5(cyclopropyl) (I-19)；R1For CH3, R3For CF3, m is 0 and Z to be C3H5(cyclopropyl) (I-20)；R1For C (CH3)3, R3It is 0 and Z to be C for H, m3H5(ring third Base) (I-21)；R1For CF2(CH3), R3It is 0 and Z to be C for Cl, m3H5(cyclopropyl) (I-22)； R1For 1-F-cyclopropyl, R3It is 0 and Z to be C for Cl, m3H5(cyclopropyl) (I-23)；R1For CH2CH3, R3It is 0 and Z to be 1-cyclo-octene base (I-24) for Cl, m；R1For CH2CH3, R3 It is 0 and Z to be ring octyl group (I-25) for Cl, m；R1For CH2CH3, R3For Cl and Z-(R4)mFor 1-OCH3-cyclohexyl (I-26)；R1For C (CH3)3, R3For H, Z-(R4)mFor 1-OH-cyclobutyl (I-27)；R1For CH3, R3For CF3And Z-(R4)mFor 1-OH-cyclobutyl (I-28)；R1For CH2CH3, R3It is 0 and Z to be C for Cl, m3H5(cyclopropyl) (I-29)；And R1For CH2CH3, R3For Cl and Z-(R4)mFor 1-OH-cyclobutyl (I-30).
11. a compositions, comprise a kind of defined Formulas I as any one of claim 1-10 Compound, its N-oxide or can agricultural salt.
12. compositionss according to claim 11, additionally comprise another active substance.
13. as any one of claim 1-10 defined compound of formula I and/or its can agricultural salt or Compositions purposes in preventing and treating plant pathogenic fungi as defined in claim 11 or 12.
14. 1 kinds of methods preventing and treating plant pathogenic fungi, at least one including use effective dose is such as weighed Profit requires defined compound of formula I any one of 1-10 or as defined in claim 11 or 12 Material, plant, soil or the seed of compositions-treated fungus fungus to be prevented invasion and attack.
15. seeds, scribble at least one such as claim 1-10 with the amount of 0.1-10kg/100kg seed Any one of defined compound of formula I and/or its can agricultural salt or as claim 11 or 12 is determined The compositions of justice.
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