Cell storage and conveying box and monitoring system
Technical field
The present invention relates to cell storaging and transport technology field, in particular to a kind of cell storage and conveying box and monitoring system.
Background technique
For cell as an independent life entity, it has the plastic of very strong vitality, Proliferation, Differentiation ability and function
Sexuality.The mechanism of cytotherapeutic treatment disease is broadly divided into two major classes: first is that the direct effect of cell, directly specific with its
Bioactivity repairing damage tissue and organ;Or play specificity/non-specific lethal effect;Second is that cell is indirect
Effect, secretes the relevant factor or bioactive molecule such as to adjust the proliferation and functional activity of patients own cells.
Cell therapy is the disease treatment new technology risen in recent years, refers to and utilizes certain cells with specific function
Characteristic has these cells and increases after being obtained using biological engineering method and/or being handled by amplification in vitro, specific culture etc.
Strong immune, kill pathogen and tumour cell promote the therapeutic efficiencies such as tissue and organ regeneration and physical recovery, to reach treatment
The purpose of disease.No matter cell is durings after obtaining and/or passing through amplification in vitro for cell therapy etc., cell cold chain transportation
As a step of interim key, especially in cell long-distance transport, the superiority and inferiority of means of transport and transportation resources is directly related to
The activity of cell eventually affects the scientific research of cell or the future use of cell therapy.
A kind of Chinese patent " blood refrigerating transport case " of Publication No. CN204433408U, the utility model overcome existing
There is incubator refrigeration effect undesirable, and it is difficult to ensure that refrigerates the deficiency of effective temperature and drying in cabinet, providing one kind can
It realizes the contact of reagent and ice chest larger area, there is good cooling effect.But the blood refrigerating transport case is only for depositing
It is stored in the invisible spectro sample of small volume, is transported if acquired with cell bags, which does not obviously reach requirement.The reality
Thermometer is housed with novel, can detecte transport the temperature inside the box, but be a lack of the function of thermograph and alarm, cause transporting
If it find that abnormal temperature change, because transport people or driver do not notice thermometer in time, that will be right during defeated
Cell, anticoagulant factor in blood product etc. generate huge injury, especially temperature and increase, it will generate irreversible damage
Wound.The Chinese patent " mobile blood transportation box " of Publication No. CN202557961U, is optimized existing storage box, solution
Handling cell bags of having determined will be from the disengaging suitable for reading of transport case, and operation is very inconvenient, and the power consumption of transportational process is higher, whole more stupid
Drawbacks such as again, but the utility model is too simple, whole process does not have any related facility of monitoring temperature, only by artificial
Perception judgement, entire transportational process is significant lower to the strict control of temperature, can not detect and sample temperature in transport is recorded
Variation, the fortuitous events such as traffic jam occur when, the vigor and quality of cell sample may be seriously affected.
Summary of the invention
The technical problem to be solved by the present invention is to be caused in the prior art due to cell bags without fixed device to overcome
Larger shaking and the activity for vibrating and reducing cell in cell bags, and due to lacking thermograph and warning function, it may lead
The defect for the huge injury for causing the cell in cell storage and conveying box to generate beyond safe temperature to cell in locating temperature, proposes one
It kind can be used for fixing cell bags and obtain and displays temperature and the cell storage and conveying box and monitoring system of implementing alarm.
A kind of cell storage and conveying box, it is characterized in that, including cabinet, case lid, the constant temperature box equipped with refrigerant and multiple cells
Storage and transportation box, the constant temperature box are set on the inside of two opposite inner sidewalls, tank floor and the case lid of the cabinet, another two relative inner
Wall is provided with internal fixed frame, and multiple cell storage and transportation boxes are mutually closely set in the constant temperature box and the inside is fixed
In the space that frame is constituted, cell bags are placed in multiple cell storage and transportation boxes.
In the present solution, by the way that multiple cell storage and transportation boxes are arranged and cell bags are respectively put into a cell storage and transportation box, and
By internal fixed frame and the fixed the multiple cell storage and transportation box of constant temperature box, it is shockproof anti-shake dynamic to make cell bags, and maintain institute
The temperature environment of cell bags is stated, there is biggish practicability.
Preferably, being formed with gap between the internal fixed frame and the cell storage and transportation box, filled in the gap
There is padded coaming, the padded coaming is sponge or blown rubber.
By filling padded coaming in the gap further between internal fixed frame and the cell storage and transportation box, further
Improve shockproof and anti-shake kinetic force.
Preferably, being equipped with a hollow insulating layer, the outer wall and inner wall of the case lid between the outer wall and inner wall of the cabinet
Between be equipped with a hollow insulating layer.
By between the inner wall of cabinet and case lid, outer wall be arranged hollow insulating layer, can by the hollow insulating layer into
One step extends the time that cell bags inner cell is in safe temperature.
Preferably, the constant temperature box being set on the inside of the case lid is connect with the case lid using latch components.
Preferably, the cell storage and conveying box includes electronic control unit, the electronic control unit includes MCU (Micro Control
Unit, micro-control unit), temperature sensor, alarm module, remote interaction module, the temperature sensor, the alarm mould
Block, the remote interaction module are electrically connected with the MCU;
The temperature sensor is used to detect the temperature in cell storage and conveying box to obtain temperature value, and the temperature value is sent out
It send to the MCU;
The MCU generates alarm signal when the temperature value is not in preset temperature range for receiving the temperature value
Breath, and the warning message is sent to the alarm module;
The alarm module is used to after receiving the warning message alarm;
The temperature value that the MCU is also used to receive is sent to the remote interaction module, the remote interaction module
It is sent out the temperature value received.
It is monitored in real time in cell storage and conveying box in the present solution, obtaining the temperature value in cell storage and conveying box by temperature sensor
Temperature and do not alarm in preset temperature range in temperature value, cell in cell storage and conveying box can be effectively ensured and be in safety
In temperature, the practicability of cell storage and conveying box is enhanced.
Preferably, the electronic control unit further includes display module, the display module is electrically connected with the MCU, described aobvious
Show module for showing the temperature value.
The temperature value obtained by real-time display, user can understand the temperature in cell storage and conveying box in time.
Preferably, the electronic control unit further includes locating module, the locating module is electrically connected with the MCU, described fixed
Position module is used to obtain and record the location information of the cell storage and conveying box, and the location information is sent to the MCU.
The location information of cell storage and conveying box can be effectively obtained by locating module, and passes through MCU and remote interaction module
It is sent out, user can receive the location information to obtain the position of cell storage and conveying box in time.
Preferably, the preset temperature range is 4 DEG C~10 DEG C.
A kind of monitoring system, it is characterized in that, it is described remote including several the cell storage and conveying boxes and remote monitoring unit
Range monitoring unit is used to receive the temperature value that the electronic control unit in the cell storage and conveying box is sent, when remote monitoring unit judgement connects
When the temperature value received is not in preset temperature range, the remote monitoring unit alarm.
In the present solution, remotely obtaining what the remote interaction module in electronic control unit was sent in time by remote monitoring unit
Temperature value can be effectively ensured the cell in cell storage box and be in safe temperature, guarantee the activity of cell.
Preferably, the electronic control unit further includes locating module, the locating module is for obtaining and recording the cell
The location information of storage and conveying box, remote monitoring unit is also used to receive the location information that the electronic control unit is sent, when long-range
When the location information that monitoring unit judgement receives does not meet preset position information, the remote monitoring unit alarm.
In the present solution, remote monitoring unit obtain in real time electronic control unit transmission location information, can be timely and effectively
Determine the position of cell storage and conveying box.
On the basis of common knowledge of the art, above-mentioned each optimum condition, can any combination to get each preferable reality of the present invention
Example.
The positive effect of the present invention is that: the biggish vibration of cell bags and rolling of storage and transportation can be effectively prevented in the present invention
The dynamic defect to cause the breakage of cell bags or cell activity is caused to reduce, and monitor cell storage and conveying box inner cell or thin in real time
The temperature or location information of born of the same parents' bag local environment, when the location information of temperature value or cell storage and conveying box in cell storage and conveying box occurs
Abnormal alarm, user can adopt an effective measure in time, enhance the practicability of cell storage and conveying box.
Detailed description of the invention
Fig. 1 is the outline structural diagram of the cell storage and conveying box of one embodiment of the invention.
Fig. 2 is the cell storage and transportation box body overlooking structure diagram of one embodiment of the invention.
Fig. 3 is the decomposition texture schematic diagram of Fig. 1.
Fig. 4 is the cell storage and conveying box case lid of one embodiment of the invention and the lock theory structure schematic diagram of constant temperature box.
Fig. 5 is the structural schematic diagram of electronic control unit in the cell storage and conveying box of one embodiment of the invention.
Fig. 6 be one embodiment of the invention include a cell storage and conveying box monitoring system structural schematic diagram.
Fig. 7 be one embodiment of the invention include multiple cell storage and conveying boxes monitoring system structural schematic diagram.
Specific embodiment
The present invention is further illustrated below by the mode of embodiment, but does not therefore limit the present invention to the reality
It applies among a range.
As shown in Figures 1 to 4, a kind of cell storage and conveying box 1, including cabinet 11, case lid 12, the constant temperature box 13 equipped with refrigerant with
And multiple cell storage and transportation boxes 14, the cell storage and conveying box 1 are rectangular body cell storage and conveying box, constant temperature box 13 is set to the cabinet 11
On the inside of two opposite inner sidewalls, 11 bottom surface of cabinet and case lid, another two opposite inner sidewalls are provided with internal fixed frame 17, multiple described
Cell storage and transportation box 14 is mutually closely set in the space that the constant temperature box 13 is constituted with the internal fixed frame 17, multiple described
Cell bags are placed in cell storage and transportation box 14, cell bags are for storing cell.
In the present solution, the two opposite sides side of internal fixed frame 17 is hierarchic structure, the two of the inside fixed frame 17 are opposite
Side resists the two sides of cell storage and transportation box 14, and the middle part of internal fixed frame 17 and the end face of cell storage and transportation box 14 form gap
16, the gap 16 is interior to be filled with padded coaming, which is sponge or blown rubber, and the type of padded coaming does not limit
In this.
Locating piece 123 there are two cuboid is set on the inner wall of case lid 12, a circle is equipped between two locating pieces 123
Cylinder fixing axle 122, opposite in the cylindrical body fixing axle 122 to be equipped with 3 positioning bars 1221, the positioning bar 1221 is equipped with
Barb assembly, the case lid 12 further include latch components 121.
It is round to be equipped with one between two cuboid through-holes 131 for rectangular through holes 131 there are two setting on the constant temperature box 13
Through-hole 132,132 side wall of circular through hole is reciprocal latch structure, when the circular through hole 132 of constant temperature box 13 is caught in into case lid 12
When in cylindrical body fixing axle 122, locating piece 123 agrees with rectangular through holes 131, and reciprocal latch structure engages with 3 positioning bars 1221
It is fixed, finally, latch components 121 and 3 positioning bar 1221 is agreed with, and rotates the latch components 121 and make positioning bar 1221
On barb assembly be fixed with the latch components 121, the constant temperature box 13 can be fixed.When the constant temperature box need to be taken out
When 13, latch components 121 described in counter-rotating can be taken off, and both be convenient for the fixation of constant temperature box 13, be also convenient for removing at any time described
Constant temperature box 13 freezes in advance to the refrigerant in the constant temperature box 13.It is convenient and practical.
In conclusion the cell storage and conveying box 1 can effectively fix cell bags, and can be mentioned for the active somatic cell in cell bags
For the short time temperature, it is shockproof it is anti-shake it is dynamic etc. require, there is certain impact property, it is convenient and practical.
As shown in figure 5, the cell storage and conveying box 1 further includes electronic control unit, which includes alarm module 101, display
Module 102, temperature sensor 103, locating module 104, remote interaction module 105 and MCU106, alarm module 101, temperature
Sensor 103, remote interaction module 105, locating module 104, display module 102 are electrically connected with MCU106.
Temperature sensor 103 is used to detect the temperature in cell storage and conveying box 1 to obtain temperature value, and the temperature value is sent out
It send to MCU106.
Locating module 104 is used to obtain and record the location information of the cell storage and conveying box 1, and the location information is sent out
It send to MCU106.
MCU106 receives the temperature value and the location information and the temperature value is sent to display module 102 and carries out
It has been shown that, display module 102 are liquid crystal display, meanwhile, the temperature value and the position are believed by remote interaction module 105
Breath is sent out, which is GPRS (General Packet Radio Service, general grouped wireless
Service technology) communication module.Above-mentioned MCU106 can (Field Programmable Gate Array, scene can compile for FPGA
Journey logic gate array) chip, DSP (Digital Signal Processor, digital signal processor) chip or embedded place
Manage device.
In addition, display module 102 is also used to show temporal information, when cell bags are placed in cell storage box 1,
MCU106 starts timing and shows on display module 102, and storage and transportation personnel can obtain the display on display module 102 at any time
Temporal information.
In addition, whether the temperature value that receives of MCU106 judgement in 4 DEG C~10 DEG C of preset temperature range of safety, if
No, MCU106 generates warning message and the warning message is sent to alarm module 101, and alarm module 101 is described in the reception
It alarms after warning message, storage and transportation personnel is reminded targetedly to implement emergency preplan.Temperature sensor 103 is set to cell
In the space for placing cell storage and transportation box 14 in storage and conveying box 1, as shown in figure 3, notch 111 is opened on the outer wall of cell storage and conveying box 1,
Display module 102 is embedded in notch 111.
As shown in fig. 6, the present embodiment also provides a kind of monitoring system, which includes a cell storage and conveying box 1 and one
Remote monitoring unit 2, the remote monitoring unit 2 are used to receive temperature value, the time that the electronic control unit in cell storage box 1 is sent
Information and location information, when remote monitoring unit 2 judges the temperature value received not in preset temperature range, time letter
Breath not in preset time range or when location information is unsatisfactory for preset position information, alarm by remote monitoring unit 2.Preset temperature
Range is 4 DEG C~10 DEG C, and preset time range is the safe preservation time for guaranteeing cell activity, which is 8 small
When~10 hours, preset position information refers to the position of preset cell storage and conveying box 1, when cell storage and conveying box 1 passes through positioning
When the location information that module 104 obtains does not meet preset position information, remote monitoring unit 2 is alarmed, and storage and transportation personnel is reminded to carry out
Tracking.
The remote monitoring unit 2 is computer, which is used to store the time letter of the cell storage and conveying box 1 remotely obtained
Breath, temperature value and location information.
As shown in fig. 7, the monitoring system can also include multiple cell storage and conveying boxes 1 and a remote monitoring unit 2, Mei Gexi
Born of the same parents' storage and conveying box 1 is equipped with different numbers, and remote monitoring unit 2 determines that the cell for carrying out data interaction stores up according to different numbers
Transport case 1.
Although specific embodiments of the present invention have been described above, it will be appreciated by those of skill in the art that these
It is merely illustrative of, protection scope of the present invention is defined by the appended claims.Those skilled in the art is not carrying on the back
Under the premise of from the principle and substance of the present invention, many changes and modifications may be made, but these are changed
Protection scope of the present invention is each fallen with modification.