CN105853775A - Oral care composition, and preparation method and application thereof - Google Patents
Oral care composition, and preparation method and application thereof Download PDFInfo
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- CN105853775A CN105853775A CN201610191363.7A CN201610191363A CN105853775A CN 105853775 A CN105853775 A CN 105853775A CN 201610191363 A CN201610191363 A CN 201610191363A CN 105853775 A CN105853775 A CN 105853775A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
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- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an oral care composition, a preparation method thereof, and an application thereof in preparation of toothpastes or mouth washes. The oral care composition comprises, by weight, 1-3 parts of honeysuckle flower, 2-5 parts of Lophatherum gracile, 2-4 parts of dahurian angelica root, 3-8 parts of Herba Houttuyniae and 0.01-0.05 parts of isopropyl methylphenol. The composition adopting Chinese herbal medicinal components as main components has the advantage of integral mildness, small irritation, realization of a very good effect through synergism of Chinese herbal medicines and isopropyl methylphenol, and good continuous use safety.
Description
Technical field
The present invention relates to a kind of mouth care compositions, be specifically related to a kind of mouth care compositions and its preparation method and application.Belong to pharmaceutical technology field.
Background technology
China resident oral disease sickness rate is the highest, but the oral care knowledge of resident lacks, and diseases prevention consciousness is weaker, still can not form the good habit of timing examination of mouth in the short time.Mouth care compositions is easy to use, it is easy to promotes, people can be helped to nurse oral cavity in very long mouth care transition development time, effectively reduces the generation of oral disease.
Periodontal disease, dental caries and halitosis etc. are all relatively common oral diseases, are various bacterial by cavity interior, and therefore killing antibacterial is prevention and the effective means improving disease in mouth.
But biocidal property is not the sole indicator considering oral care article, there is a lot of different types of medicated toothpaste, regrettably, the crowd of many commonly used medicated toothpaste the most inevitably suffers from the diseases such as periodontitis, this is because existing medicated toothpaste contains alkaloid and the strong material of zest mostly, life-time service, not only damages oral mucosa, also can cause gingivitis, stomatitis and glossitis etc..Chinese herbal medicine relatively safety and zest are little, but fungistatic effect is not ideal enough.Now it is badly in need of a kind of good antimicrobial effect and has the oral care article of lasting safety in utilization concurrently.
Summary of the invention
It is an object of the invention to as overcoming above-mentioned the deficiencies in the prior art, it is provided that a kind of mouth care compositions, good antimicrobial effect, and it is good to continue safety in utilization.
Present invention also offers its preparation method and for preparing the application of toothpaste or collutory.
For achieving the above object, the present invention uses following technical proposals:
A kind of mouth care compositions, is made up of the component of following weight portion: Flos Lonicerae 1～3 parts, Herba Lophatheri 2～5 parts, the Radix Angelicae Dahuricae 2～4 parts, Herba Houttuyniae 3～8 parts, isopropyl methyl phenol 0.01～0.05 part.
Preferably, it is made up of the component of following weight portion: Flos Lonicerae 1～2 parts, Herba Lophatheri 3～4 parts, the Radix Angelicae Dahuricae 3～4 parts, Herba Houttuyniae 5～7 parts, isopropyl methyl phenol 0.02～0.04 part.
It is further preferred that be made up of the component of following weight portion: 1 portion of Flos Lonicerae, 4 portions of Herba Lophatheris, 3 parts of Radixs Angelicae Dahuricae, 6 parts of Herba Houttuyniae, 0.03 part of isopropyl methyl phenol.
The preparation method of above-mentioned mouth care compositions, including step:
1) by percent by volume 60～the ethanol water mixing of 90% of the Flos Lonicerae of formula ratio, Herba Lophatheri, the Radix Angelicae Dahuricae and Herba Houttuyniae and 2～5 times of weight, reflux 1～3 hour, filter, obtain filtrate；
2) gained filtering residue is continued percent by volume with 2～5 times of weight of filtering residue 60～90% ethanol water mix and refluxes 1～3 hour, filtration, obtain filtrate, and with step 1) in gained filtrate merge；
3) the isopropyl methyl phenol of formula ratio is joined step 2) in gained filtrate, supersonic oscillations 10～after 15 minutes, it is heated to reflux 1～3 hour, being concentrated into relative density while hot is 1.2～1.25 and get final product.
Step 3) in relative density be 60 DEG C and record.
Above-mentioned mouth care compositions is for preparing the application of toothpaste or collutory.The mouth care compositions of the present invention can join in toothpaste or collutory as functional additive, prepares toothpaste or the collutory of bacteria resistance function.
Beneficial effects of the present invention:
The present invention is based on medicinal herb components, and adds a small amount of nonionic antibacterial isopropyl methyl phenol, and the latter has the antibacterial characteristics of wide spectrum, can penetrate in periodontal disease pathogenic organisms film antibacterial, effectively prevent periodontal disease.Owing to the compositions of the present invention is based on medicinal herb components, entirety is gentleer, and zest is less, and Chinese herbal medicine and isopropyl methyl phenol synergism reach good fungistatic effect.
Medicinal herb components ethanol water is first extracted by the present invention, rear addition isopropyl methyl phenol, owing to isopropyl methyl phenol dissolubility in water is poor, in ethanol water system, there will be the situation that medicinal herb components can not be mixed homogeneously with isopropyl methyl phenol, and isopropyl methyl phenol content is less, mixes uneven meeting and directly affect the fungistatic effect of resulting composition.The present invention, after adding isopropyl methyl phenol, first passes through supersonic oscillations and processes, and is then heated to reflux processing a period of time, it is ensured that being uniformly distributed of each composition.
Common to oral cavity for the toothpaste utilizing said composition to make aerobe and anaerobe are carried out bacteriostatic test, the inhibition zone diameter of aerobe is bigger than the tooth paste product on market, the minimum inhibitory concentration of anaerobe is lower than the tooth paste product on market, illustrates that the compositions of the present invention has extraordinary fungistatic effect.And by human efficiency's research, the volunteer suffering from periodontal disease problem is tested, test the toothpaste and toothpaste on market using the present composition to make, find to use the toothpaste made of the present invention can effective reduction of patient periodontal disease situation, persistently there are not other oral problem in tracking some months.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further elaborated, it should explanation, and its content, merely to explain the present invention, is not defined by the description below.
Embodiment 1:
The mouth care compositions of the present invention, is composed of the following components: Flos Lonicerae 1kg, Herba Lophatheri 2kg, Radix Angelicae Dahuricae 2kg, Herba Houttuyniae 3kg, isopropyl methyl phenol 0.01kg.
The preparation method of this mouth care compositions, including step:
1) ethanol water of the Flos Lonicerae of formula ratio, Herba Lophatheri, the Radix Angelicae Dahuricae and Herba Houttuyniae with 16kg percent by volume 60% is mixed, reflux 1 hour, filter, obtain filtrate；
2) continue mix with the ethanol water of the percent by volume 60% of 2 times of weight of filtering residue by gained filtering residue and reflux 1 hour, filtration, obtain filtrate, and with step 1) in gained filtrate merge；
3) the isopropyl methyl phenol of formula ratio being joined step 2) in gained filtrate, supersonic oscillations, after 10 minutes, are heated to reflux 1 hour, are concentrated into relative density while hot and are 1.2 (60 DEG C record) and get final product.
Embodiment 2:
The mouth care compositions of the present invention, is composed of the following components: Flos Lonicerae 3kg, Herba Lophatheri 5kg, Radix Angelicae Dahuricae 4kg, Herba Houttuyniae 8kg, isopropyl methyl phenol 0.05kg.
The preparation method of this mouth care compositions, including step:
1) ethanol water of the Flos Lonicerae of formula ratio, Herba Lophatheri, the Radix Angelicae Dahuricae and Herba Houttuyniae with 100kg percent by volume 90% is mixed, reflux 3 hours, filter, obtain filtrate；
2) continue mix with the ethanol water of the percent by volume 90% of 5 times of weight of filtering residue by gained filtering residue and reflux 3 hours, filtration, obtain filtrate, and with step 1) in gained filtrate merge；
3) the isopropyl methyl phenol of formula ratio being joined step 2) in gained filtrate, supersonic oscillations, after 15 minutes, are heated to reflux 3 hours, are concentrated into relative density while hot and are 1.25 (60 DEG C record) and get final product.
Embodiment 3:
The mouth care compositions of the present invention, is composed of the following components: Flos Lonicerae 1kg, Herba Lophatheri 3kg, Radix Angelicae Dahuricae 3kg, Herba Houttuyniae 5kg, isopropyl methyl phenol 0.02kg.
The preparation method of this mouth care compositions, including step:
1) ethanol water of the Flos Lonicerae of formula ratio, Herba Lophatheri, the Radix Angelicae Dahuricae and Herba Houttuyniae with 36kg percent by volume 80% is mixed, reflux 2 hours, filter, obtain filtrate；
2) gained filtering residue is continued percent by volume with 3 times of weight of filtering residue 60～90% ethanol water mix and refluxes 2 hours, filtration, obtain filtrate, and with step 1) in gained filtrate merge；
3) the isopropyl methyl phenol of formula ratio being joined step 2) in gained filtrate, supersonic oscillations, after 12 minutes, are heated to reflux 2 hours, are concentrated into relative density while hot and are 1.2 (60 DEG C record) and get final product.
Embodiment 4:
The mouth care compositions of the present invention, is composed of the following components: Flos Lonicerae 2kg, Herba Lophatheri 4kg, Radix Angelicae Dahuricae 4kg, Herba Houttuyniae 7kg, isopropyl methyl phenol 0.04kg.
The preparation method of this mouth care compositions, including step:
1) ethanol water of the Flos Lonicerae of formula ratio, Herba Lophatheri, the Radix Angelicae Dahuricae and Herba Houttuyniae with 34kg percent by volume 80% is mixed, reflux 2 hours, filter, obtain filtrate；
2) continue mix with the ethanol water of the percent by volume 80% of 2 times of weight of filtering residue by gained filtering residue and reflux 2 hours, filtration, obtain filtrate, and with step 1) in gained filtrate merge；
3) the isopropyl methyl phenol of formula ratio being joined step 2) in gained filtrate, supersonic oscillations, after 10 minutes, are heated to reflux 2 hours, are concentrated into relative density while hot and are 1.25 (60 DEG C record) and get final product.
Embodiment 5:
The mouth care compositions of the present invention, is composed of the following components: Flos Lonicerae 1kg, Herba Lophatheri 4kg, Radix Angelicae Dahuricae 3kg, Herba Houttuyniae 6kg, isopropyl methyl phenol 0.03kg.
The preparation method of this mouth care compositions, including step:
1) ethanol water of the Flos Lonicerae of formula ratio, Herba Lophatheri, the Radix Angelicae Dahuricae and Herba Houttuyniae with 42kg percent by volume 80% is mixed, reflux 2 hours, filter, obtain filtrate；
2) continue mix with the ethanol water of the percent by volume 80% of 3 times of weight of filtering residue by gained filtering residue and reflux 2 hours, filtration, obtain filtrate, and with step 1) in gained filtrate merge；
3) the isopropyl methyl phenol of formula ratio being joined step 2) in gained filtrate, supersonic oscillations, after 12 minutes, are heated to reflux 2 hours, are concentrated into relative density while hot and are 1.2 (60 DEG C record) and get final product.
Test example
The mouth care compositions of embodiment 1～5 all can join in toothpaste or collutory as functional additive, prepares toothpaste or the collutory of bacteria resistance function.As a example by toothpaste, the fungistatic effect of the present composition is studied below.
The compositions of Example 1～5 respectively, mix with base material stone powder, sodium lauryl sulfate, cellulose, glycerol, sodium silicate, essence, xerogel, sodium benzoate and deionized water, prepare toothpaste, the content of the most each composition is as shown in table 1, the toothpaste that embodiment 1～5 compositions prepares is respectively labeled as A, B, C, D, E, buy a antibacterial toothpaste on market at random, be labeled as F.
Each component content in table 1. toothpaste
| Composition | Weight/mass percentage composition/% |
| The compositions of the present invention | 0.2 |
| Base material stone powder | 45 |
| Sodium lauryl sulfate | 1.5 |
| Cellulose | 1 |
| Glycerol | 13 |
| Sodium silicate | 2 |
| Essence | 1 |
| Xerogel | 1 |
| Sodium benzoate | 0.3 |
| Deionized water | 35 |
Test toothpaste A, B, C, D, E, F bacteriostatic test (inhibition zone diameter, mm) to aerobe respectively, and the bacteriostatic test (minimum inhibitory concentration, MIC, %) to anaerobe, result of the test is shown in Table 2 and table 3.In table 2, strain subject is that gained is bought in market, staphylococcus aureus (ATCC 6538), staphylococcus epidermidis (ATCC 12228), Streptococcus mutans (ATCC 25175), porphyromonas sporangium (ATCC 33277).
The table 2. toothpaste antibacterial result to aerobe
From Table 2, it can be seen that the toothpaste that the compositions of the present invention is made is substantially better than market product to the fungistatic effect of aerobe.
The table 3. toothpaste antibacterial result to anaerobe
From table 3 it can be seen that the toothpaste that the compositions of the present invention is made is substantially better than market product to the fungistatic effect of anaerobe.
By human efficiency's research, the volunteer suffering from periodontal disease problem is tested, examination of mouth before and after test is performed by the Dentist of specialty, choose 120 volunteers's (all having inflammation) suffering from periodontitis to test, it is randomly divided into 6 groups, often organize 20 people, each group is randomly assigned use toothpaste A, B, C, D, E or F, records the number of NIP, the results are shown in Table 4 after one month.
Table 4. uses toothpaste demographics of NIP after month
| Toothpaste | The number (people) of NIP |
| A | 20 |
| B | 20 |
| C | 20 |
| D | 20 |
| E | 20 |
| F | 15 |
From table 4, it can be seen that the toothpaste that the present composition is made can effectively cure periodontitis after using one month so that inflammation disappears, and is better than market antibacterial toothpaste product.
Above-mentioned crowd was continuing with toothpaste to five months, checks its oral condition every month, the results are shown in Table 5.
Table 5. uses toothpaste demographics of NIP after month
As can be seen from Table 5, persistently follow the tracks of 5 months, there are not other oral problem in the toothpaste using the present composition to make, and although periodontitis inflammation disappears after using toothpaste F to 2 months, but there is patient that the situation that periodontitis recurs occurs to the 3rd the end of month, and have patient to occur in that other oral problem such as halitosis and canker sore after using 2 months.As can be seen here, the compositions of the present invention continues safety in utilization more preferably.
Although the above-mentioned detailed description of the invention to the present invention is described; but not limiting the scope of the invention; on the basis of technical scheme, those skilled in the art need not to pay various amendments or deformation that creative work can make still within protection scope of the present invention.
Claims (6)
1. a mouth care compositions, it is characterised in that be made up of the component of following weight portion: Flos Lonicerae 1～3
Part, Herba Lophatheri 2～5 parts, the Radix Angelicae Dahuricae 2～4 parts, Herba Houttuyniae 3～8 parts, isopropyl methyl phenol 0.01～0.05 part.
A kind of mouth care compositions the most according to claim 1, it is characterised in that be by the group of following weight portion
It is grouped into: Flos Lonicerae 1～2 parts, Herba Lophatheri 3～4 parts, the Radix Angelicae Dahuricae 3～4 parts, Herba Houttuyniae 5～7 parts, isopropyl methyl
Phenol 0.02～0.04 part.
A kind of mouth care compositions the most according to claim 1, it is characterised in that be by the group of following weight portion
It is grouped into: 1 portion of Flos Lonicerae, 4 portions of Herba Lophatheris, 3 parts of Radixs Angelicae Dahuricae, 6 parts of Herba Houttuyniae, 0.03 part of isopropyl methyl phenol.
4. the preparation method of the compositions according to any one of claims 1 to 3, it is characterised in that include step:
1) by the percent by volume 60～90% of the Flos Lonicerae of formula ratio, Herba Lophatheri, the Radix Angelicae Dahuricae and Herba Houttuyniae and 2～5 times of weight
Ethanol water mixing, reflux 1～3 hour, filtration, obtain filtrate；
2) gained filtering residue is continued percent by volume with 2～5 times of weight of filtering residue 60～90% ethanol water mix back
Flow 1～3 hour, filter, obtain filtrate, and with step 1) in gained filtrate merge；
3) the isopropyl methyl phenol of formula ratio is joined step 2) in gained filtrate, supersonic oscillations 10～after 15 minutes,
Being heated to reflux 1～3 hour, being concentrated into relative density while hot is 1.2～1.25 and get final product.
Preparation method the most according to claim 4, it is characterised in that step 3) in relative density be 60 DEG C and record.
6. the compositions according to any one of claims 1 to 3 is for preparing the application of toothpaste or collutory.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610191363.7A CN105853775A (en) | 2016-03-30 | 2016-03-30 | Oral care composition, and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610191363.7A CN105853775A (en) | 2016-03-30 | 2016-03-30 | Oral care composition, and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619387A (en) * | 2017-01-20 | 2017-05-10 | 两面针（江苏）实业有限公司 | Liquid soap for foot bath and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102573770A (en) * | 2009-11-06 | 2012-07-11 | 狮王株式会社 | Isopropyl methyl phenol-containing liquid composition for oral cavity |
| CN103735581A (en) * | 2014-01-17 | 2014-04-23 | 刘少华 | Care solution for cleaning nasal cavity and preparation method of care solution |
-
2016
- 2016-03-30 CN CN201610191363.7A patent/CN105853775A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102573770A (en) * | 2009-11-06 | 2012-07-11 | 狮王株式会社 | Isopropyl methyl phenol-containing liquid composition for oral cavity |
| CN103735581A (en) * | 2014-01-17 | 2014-04-23 | 刘少华 | Care solution for cleaning nasal cavity and preparation method of care solution |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619387A (en) * | 2017-01-20 | 2017-05-10 | 两面针（江苏）实业有限公司 | Liquid soap for foot bath and preparation method thereof |
| CN106619387B (en) * | 2017-01-20 | 2019-06-11 | 两面针（江苏）实业有限公司 | The preparation method of liquid toliet soap for lavipeditum |
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